Alcohol and cortisol

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Recent research has looked into the effects of alcohol on the amount of cortisol that is produced in the human body.
Continuous consumption of alcohol over an extended period of time has been shown to raise cortisol levels in the
body. Cortisol is released during periods of high stress, and can result in the temporary shut down of other physical
processes, causing physical damage to the body.

Contents
1 Alcohol
2 Cortisol
3 Alcohol and cortisol interactions
3.1 History
3.2 Recent findings
4 References

Alcohol
Alcohol is a psychoactive drug that has numerous effects on the functioning of the human body. Specifically, alcohol
largely affects the body’s endocrine system, resulting in changes of various hormone levels caused by impairment of
hormone-releasing glands and of target tissues. Hormonal changes may play a large role in alcohol-seeking behavior.
Additionally, changes in hormonal levels may explain causation for relapse behavior in recovering alcoholics.

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 Cortisol
Cortisol is a stress hormone secreted by the adrenal gland, which makes up part of the hypothalamic-pituitary-adrenal
(HPA) axis. It is typically released at periods of high stress designed to help the individual cope with stressful
situations.[1] Cortisol secretion results in increased heart rate and blood pressure and the temporary shut down of
metabolic processes such as digestion, reproduction, growth, and immunity as a means of conserving energy for the
stress response. Chronic release of cortisol over extended periods of time caused by long-term high stress can result
in:

Fatigue
Hypertension
Ulcers
Hampered growth
Cancer
Accelerated neural degeneration during aging
Impaired immune system.[2]

Alcohol and cortisol interactions

High cortisol levels have largely been associated with high alcohol consumption, which is likely due to the disregulation
(impaired inhibitory control) of the HPA axis.[1]

History

Research on alcohol’s effects on cortisol dates back to the 1950s. Many studies showed a relation between the two,
however they were limited to short-term alcohol ingestion. The first human study to assess the long-term effects of
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 alcohol ingestion on cortisol was conducted in 1966 (Mendelson et al.). They found heightened cortisol levels in both
alcoholics and non-alcoholics while actively drinking. Cortisol was overall higher in alcoholics than non-alcoholics,
indicating that alcohol has long-term effects on the endocrine system. Also, alcoholics had the highest cortisol levels
after drinking stopped, demonstrating symptoms of withdrawal (a hormonal marker of alcohol addiction).[3]

Recent findings
Recent research supports this strong association between high alcohol use and heightened cortisol levels. In one
study, overnight urinary cortisol levels were taken from people who regularly drank a large amount of alcohol versus a
small amount of alcohol. People who drank more alcohol had higher cortisol levels and lower heart rate variability
(which is controlled by the autonomic nervous system, ANS), suggesting a connection between the HPA axis and the
ANS. People who drank more alcohol had higher blood pressure and difficulty sleeping, indicative of heightened
cortisol levels.[4]

Recent technology has allowed researchers to measure cortisol levels in human hair (showing cumulative cortisol
exposure over extended periods of time). This method of measurement has been used to compare long-term cortisol
levels in alcoholics, abstinent alcoholics, and non-alcoholics. One recent study revealed that alcoholics had three to
four times higher hair cortisol concentrations than abstinent alcoholics or non-alcoholics (consistent with previous
research showing periods of alcohol consumption are associated with heightened cortisol levels). Abstinent alcoholics
and non-alcoholics had the same low levels of cortisol, suggesting that cortisol levels eventually return to normal after
extended cessation.[5]

References
1. ^ a b Dai, Xing; Thavundayil, Joseph; Santella, Sandra; Gianoulakis, Christina (2007). "Response of the HPA-axis to alcohol
and stress as a function of alcohol dependence and family history of alcoholism". Psychoneuroendocrinology 32 (3): 293–
305. doi:10.1016/j.psyneuen.2007.01.004 (http://dx.doi.org/10.1016%2Fj.psyneuen.2007.01.004). PMID 17349749
(https://www.ncbi.nlm.nih.gov/pubmed/17349749).
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 2. ^ Lupien, Sonia J.; McEwen, Bruce S.; Gunnar, Megan R.; Heim, Christine (2009). "Effects of stress throughout the lifespan
on the brain, behaviour and cognition". Nature Reviews Neuroscience 10 (6): 434–45. doi:10.1038/nrn2639
(http://dx.doi.org/10.1038%2Fnrn2639). PMID 19401723 (https://www.ncbi.nlm.nih.gov/pubmed/19401723).
3. ^ Mendelson, Jack; Stein, Stefan (1966). "Serum Cortisol Levels in Alcoholic and Nonalcoholic Subjects During
Experimentally Induced Ethanol Intoxication" (http://www.psychosomaticmedicine.org/content/28/4/616.abstract).
Psychosomatic Medicine 28 (4): 616–26. Retrieved 2014-01-07.
4. ^ Thayer, Julian F.; Hall, Martica; Sollers, John J.; Fischer, Joachim E. (2006). "Alcohol use, urinary cortisol, and heart rate
variability in apparently healthy men: Evidence for impaired inhibitory control of the HPA axis in heavy drinkers".
International Journal of Psychophysiology 59 (3): 244–50. doi:10.1016/j.ijpsycho.2005.10.013
(http://dx.doi.org/10.1016%2Fj.ijpsycho.2005.10.013). PMID 16325293 (https://www.ncbi.nlm.nih.gov/pubmed/16325293).
5. ^ Stalder, Tobias; Kirschbaum, Clemens; Heinze, Kareen; Steudte, Susann; Foley, Paul; Tietze, Antje; Dettenborn, Lucia
(2010). "Use of hair cortisol analysis to detect hypercortisolism during active drinking phases in alcohol-dependent
individuals". Biological Psychology 85 (3): 357–60. doi:10.1016/j.biopsycho.2010.08.005
(http://dx.doi.org/10.1016%2Fj.biopsycho.2010.08.005). PMID 20727937 (https://www.ncbi.nlm.nih.gov/pubmed/20727937).

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Categories: Stress Alcohol and health

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