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CRITICAL CARE DRUG COMPATIBILITY CHART

Full Title of Guideline: Critical care drug compatibility chart.


Critical Care Pharmacists.
Author (include email and role):
elizabeth.jamieson@nuh.nhs.uk
Division & Speciality: Clinical Support, Critical Care. Medicine, Cardiac Surgery
Version:
Critical care governance group. Cardiac governance
Ratified by:
group.
Scope (Target audience, state if Trust Critical care and CICU nurses, doctors and pharmacists.
wide):
Review date (when this version goes out January 2019. Do not use after January 2020.
of date):
Explicit definition of patient group Adult critical care and cardiac surgery patients.
to which it applies (e.g. inclusion and
exclusion criteria, diagnosis):
Plasmalyte and milrinone added. Rocuronium/propofol
Changes from previous version (not changed to incompatible.
applicable if this is a new guideline, enter
below if extensive):

Summary of evidence base this Consult critical care pharmacists for full references.
guideline has been created from:
This guideline has been registered with the trust. However, clinical guidelines are
guidelines only. The interpretation and application of clinical guidelines will remain the
responsibility of the individual clinician. If in doubt contact a senior colleague or expert.
Caution is advised when using guidelines after the review date or outside of the Trust.

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Adrenaline
Alfentanil
Directorate of Critical Care IV Drug Compatibility Chart
Aminophylline
Amiodarone
Atracurium
Ciprofloxacin Two drug Y- site Compatibility
Cis-atracurium
Incompatible at Y site
Clonidine
Digoxin
Dobutamine Compatible at Y site
Dopamine
Erythromycin Contact pharmacy for advice
Fluconazole
Furosemide
Hartmann’s (Compound Sodium Lactate)
Heparin
Hydralazine
Insulin
Ketamine
Labetalol
Magnesium in NaCl 0.9%
Midazolam
Milrinone
Morphine
Nitroglycerin (Glyceryl trinitrate; GTN)
Noradrenaline
Phenytoin
Plasmalyte
Potassium Chloride
Potassium Acid Phosphate
Propofol
Rocuronium
Sodium bicarbonate
Thiopental
Vancomycin
Vasopressin

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This chart is only applicable for drugs prepared and diluted as per the NUH Critical Care standard infusion chart 2016,
or CICU standard infusions table 2017.
For other enquiries please contact either the Critical Care pharmacist or Medicines Information.
Out of hours please contact on- call pharmacist via switchboard.

Adult Critical Care Compatibility Information


Although the routine co-administration of drugs at Y site should be avoided wherever possible the following is a list of common drug
infusion combinations when access is limited:

Lumen One - Inotropes in Dextrose 5% in any combination:

- Noradrenaline, Adrenaline or Dobutamine with Amiodarone


- Noradrenaline or Adrenaline with Neat Potassium chloride NB: on CICU neat potassium chloride ideally should have a
dedicated lumen (as part of the local agreement).

If no alternative 3 of the following may be co-administered: - Noradrenaline, Adrenaline, Milrinone or Dobutamine


- Noradrenaline, Adrenaline, Milrinone or Dopamine

Lumen Two - Sedation in Sodium Chloride 0.9%:


- Morphine or Alfentanil with Midazolam If there is no alternative the following combinations may be co-administered:
- Morphine or Midazolam with Atracurium - Morphine, Midazolam and Propofol
- Alfentanil or Morphine with Propofol - Morphine, Midazolam and Atracurium
- Alfentanil with Atracurium - Alfentanil, Midazolam and Atracurium
- Midazolam with Propofol - Midazolam, Morphine and Rocuronium
- Morphine or Midazolam with Rocuronium

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