7034_11MM19_129_156_INF.

indd 1185

Table 132–3. USUAL DOSES OF COMMONLY PRESCRIBED ANTIBIOTICS

PEDIATRIC
ADULT DOSE (AGE > 1 MO) DOSE
DOSE IN RENAL
SERIOUS FAILUREa (CrCl
DRUG ORAL PARENTERAL INFECTIONS ORAL PARENTERAL < 10 mL/min)

Aminoglycosides
Amikacin N/A 15 mg/kg 15 mg/kg N/A 5–7.5 mg/kg IV 1.5–2.5 mg/kg IV
IV once/day IV once/day q 12 h q 24–48 h
or or
7.5 mg/kg q 12 h 7.5 mg/kg IV q 12 h
Gentamicin N/A 5–7 mg/kg 5–7 mg/kg N/A 1–2.5 mg/kg IV 0.34–0.51 mg/kg IV
IV once/day IV once/day q8h q 24–48 h

CHAPTER 132
or
1.7 mg/kg IV q 8 h
For synergy with N/A 1 mg/kg IV q 8 h N/A N/A 1 mg/kg IV q 8 h Infectious disease con-
a cell wall–active sultation required for
antibiotic to treat dosage
enterococcal en- Dosage adjusted to
docarditis caused achieve peak serum

Bacteria and Antibacterial Drugs

by strains suscepti- concentration of
ble to gentamicin 3–4 µg/mL and
trough concentration
of < 1 µg/mL
For streptococcal or — 1 mg/kg IV q 8 h N/A N/A 1 mg/kg IV q 8 h N/A
Staphylococcus au- or or
reus endocarditis 3 mg/kg IV once/day 3 mg/kg IV once/day
Neomycin
For preoperative 1 g for 3 doses N/A N/A 15 mg/kg q 4 h N/A N/A
gut antisepsis (eg, at 1, 2, and for 2 days
(with erythromy- 11 pm on the or
cin and mechani- day before 25 mg/kg at 1, 2, and
cal cleansing) surgery) 11 pm on the day
3/11/11 10:34 AM

1185
before surgery

Table continues on the following page.

7034_11MM19_129_156_INF.indd 1186

Table 132–3. USUAL DOSES OF COMMONLY PRESCRIBED ANTIBIOTICS (Continued )

1186
PEDIATRIC
ADULT DOSE (AGE > 1 MO) DOSE
DOSE IN RENAL

SECTION 11
SERIOUS FAILUREa (CrCl
DRUG ORAL PARENTERAL INFECTIONS ORAL PARENTERAL < 10 mL/min)

For hepatic coma 1–3 g qid N/A N/A 0.6–1.75 g/m2 q 6 h N/A N/A
or
0.4–1.2 g/m2 q 4 h

Infectious Diseases
Streptomycin
For TB N/A 15 mg/kg IM q 24 h N/A N/A 20–40 mg/kg IM 7.5 mg/kg IM
(maximum: 1.0 g/ once/day q 72–96 h
day) initially, then (maximum: 1 g)
1.0 g 2–3 times/wk
For synergy with a N/A 7.5 mg/kg IM q 12 h N/A N/A N/A N/A
cell wall–active
antibiotic to treat
enterococcal
endocarditis
Tobramycin N/A 5–7 mg/kg 5–7 mg/kg IV N/A 1–2.5 mg/kg IV 0.34–0.51 mg/kg IV
IV once/day once/day q8h q 24–48 h
or or
1.7 mg/kg IV q 8 h 1.7 mg/kg IV q 8 h
β-Lactams: Cephalosporins (1st generation)
Cefadroxil 0.5–1 g q 12 h N/A N/A 15 mg/kg q 12 h N/A 0.5 g po q 36 h
Cefazolin N/A 1–2 g IV q 8 h 2 g IV q 8 h N/A 16.6–33.3 mg/kg IV 1–2 g IV
q8h q 24–48 h
Cephalexin 0.25–0.5 g N/A N/A 6.25–12.5 mg/kg q 6 h N/A 0.25–0.5 g po
q6h or q 24–48 h
8.0–16 mg/kg q 8 h
3/11/11 10:34 AM

Table continues on the following page.

7034_11MM19_129_156_INF.indd 1187

Table 132–3. USUAL DOSES OF COMMONLY PRESCRIBED ANTIBIOTICS (Continued )

PEDIATRIC
ADULT DOSE (AGE > 1 MO) DOSE
DOSE IN RENAL
SERIOUS FAILUREa (CrCl
DRUG ORAL PARENTERAL INFECTIONS ORAL PARENTERAL < 10 mL/min)

β-Lactams: Cephalosporins (2nd generation)

Cefaclorb 0.25–0.5 g N/A N/A 10–20 mg/kg q 12 h N/A 0.5 g po q 12 h
q8h or
6.6–13.3 mg/kg q 8 h
Cefotetan N/A 1–3 g IV q 12 h 2–3 g IV N/A 20–40 mg/kg IV 1–3 g IV q 48 h
q 12 h q 12 h
Cefoxitin N/A 1 g IV q 8 h to 2 g 2 g IV q 4 h N/A 27–33 mg/kg IV q 8 h 0.5–1.0 g IV

CHAPTER 132
IV q 4 h or or, for severe infec- q 24–48 h
3 g IV q 6 h tions, 25–40 mg/kg
q6h
Cefprozil 0.25 g q 12 h N/A N/A 15 mg/kg q 12 h for N/A 0.25 g po q 12–24 h
or otitis media
0.5 g q 12–24 h

Bacteria and Antibacterial Drugs

Cefuroxime 0.125–0.5 g 0.75–1.5 g IV 1.5 g IV q 6 h 10–15 mg/kg suspension 25–50 mg/kg IV 0.25–0.5 g po q 24 h
q 12 h q 6–8 h q 12 h q8h or
For older children: 0.75 g IV q 24 h
125–250 mg tablets
q 12 h
For meningitis 3 g IV q 8 h 50–60 mg/kg IV q 6 h
β-Lactams: Cephalosporins (3rd generation)
Cefoperazone N/A 1 g q 12 h to 2 g IV 2 g IV q 4 h N/A 25–100 mg/kg IV Same as adult dose
q4h q 12 h
Cefotaxime N/A 1 g q 12 h to 2 g IV 2 g IV q 4 h N/A 8.3–33.3 mg/kg IV 1–2 g IV q 24 h
q4h q4h
or
3/11/11 10:34 AM

1187
16.6–66.6 mg/kg q 6 h

Table continues on the following page.

7034_11MM19_129_156_INF.indd 1188

Table 132–3. USUAL DOSES OF COMMONLY PRESCRIBED ANTIBIOTICS (Continued )

1188
PEDIATRIC
ADULT DOSE (AGE > 1 MO) DOSE
DOSE IN RENAL

SECTION 11
SERIOUS FAILUREa (CrCl
DRUG ORAL PARENTERAL INFECTIONS ORAL PARENTERAL < 10 mL/min)
c
Cefpodoxime 0.1–0.4 g q 12 h N/A N/A 5 mg/kg q 12 h N/A 0.1–0.4 g po q 24 h
Ceftazidime N/A 1 g IV q 12 h to 2 g 2 g IV q 8 h N/A 25–50 mg/kg IV 0.5 g IV q 24–48 h
q8h q8h

Infectious Diseases
Ceftibutenb 0.4 g q 24 h N/A N/A 9 mg/kg once/day N/A 0.1 g po q 24 h
Ceftizoxime N/A 0.5 g IV q 12 h to 4 g IV q 8 h N/A 50 mg/kg IV 0.5 g IV q 24 h to
4 g IV q 8 h q 6–8 h 0.5–1 g IV q 48 h
Ceftriaxone N/A 1–2 g IV q 24 h 2 g IV q 24 h N/A 50–75 mg/kg IV q 24 h Same as adult dose
or
25–37.5 mg/kg q 12 h
For meningitis N/A 2 g IV q 12 h 2 g IV q 12 h N/A 50 mg/kg IV q 12 h or 2 g IV q 12 h
100 mg/kg q 24 h (not
to exceed 4 g/day)
Possibly a loading
dose of 100 mg/kg
IV (not to exceed 4 g)
at the start of therapy
β-Lactams: Cephalosporin (4th generation)
Cefepime N/A 1–2 g IV q 8–12 h 2 g IV q 8 h N/A 50 mg/kg IV q 8–12 h 0.25–1 g IV q 24 h
β-Lactams: Penicillins
Amoxicillin 0.25–0.5 g q 8 h N/A N/A 12.5–25 mg/kg q 12 h N/A 0.25–0.5 g po q 24 h
or or
0.875 g q 12 h 7–13 mg/kg q 8 h
For endocarditis 2 g for 1 dose N/A N/A 50 mg/kg 1 h before N/A 2 g po for 1 dose
prophylaxis procedure
3/11/11 10:34 AM

Amoxicillin/ 0.25–0.5 g q 8 h N/A N/A If > 40 kg: Adult dose N/A 0.25–0.5 g po q 24 h
clavulanate or
0.875 g q 12 h
Table continues on the following page.
7034_11MM19_129_156_INF.indd 1189

Table 132–3. USUAL DOSES OF COMMONLY PRESCRIBED ANTIBIOTICS (Continued )

PEDIATRIC
ADULT DOSE (AGE > 1 MO) DOSE
DOSE IN RENAL
SERIOUS FAILUREa (CrCl
DRUG ORAL PARENTERAL INFECTIONS ORAL PARENTERAL < 10 mL/min)

Amoxicillin/clavu- N/A N/A N/A 45 mg/kg q 12 h N/A N/A

lanate, ES-600
Amoxicillin/clavu- 2 g q 12 h N/A N/A N/A N/A N/A
lanate, extended-
release
Ampicillin N/A 0.5–2.0 g IV q 4–6 h 2 g IV q 4 h N/A 25–50 mg/kg IV q 6 h 0.5–2.0 g IV q 12–24 h
For meningitis N/A 2 g IV q 4 h 2 g IV q 4 h N/A 50–100 mg/kg IV 2 g IV q 12 h

CHAPTER 132
q6h
Ampicillin/ N/A 1.5–3.0 g IV q 6 h 3 g IV q 6 h N/A 25–50 mg/kg IV q 6 h 1.5–3.0 g IV q 24 h
sulbactam
(3 g = 2 g ampicillin
+ 1 g sulbactam)
Dicloxacillinb 0.125–0.5 g q 6 h N/A N/A 3.125–6.25 mg/kg q 6 h N/A 0.125–0.5 g po q 6 h

Bacteria and Antibacterial Drugs

Nafcillin Rarely used 1–2 g IV q 4 h 2 g IV q 4 h N/A 12.5–25 mg/kg IV 1–2 g IV q 4 h
q6h
or
8.3–33.3 mg/kg q 4 h
Oxacillin Rarely used 1–2 g IV q 4 h 2 g IV q 4 h N/A 12.5–25 mg/kg IV 1–2 g IV q 4 h
q6h
or
8.3–33.3 mg/kg IV
q4h
Penicillin Gb 0.25–0.5 g 1–4 million units IV 4 million units IV Penicillin VK 6,250–100,000 units/ 0.5–2 million units
q 6–12 h q 4–6 h q4h 6.25–12.5 mg/kg kg IV q 6 h IV q 4–6 h
(penicillin V) q8h or (maximum total
4,166.6–66,666 daily dose: 6 million
3/11/11 10:34 AM

1189
units/kg IV q 4 h units/day)

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7034_11MM19_129_156_INF.indd 1190

Table 132–3. USUAL DOSES OF COMMONLY PRESCRIBED ANTIBIOTICS (Continued )

1190
PEDIATRIC
ADULT DOSE (AGE > 1 MO) DOSE
DOSE IN RENAL

SECTION 11
SERIOUS FAILUREa (CrCl
DRUG ORAL PARENTERAL INFECTIONS ORAL PARENTERAL < 10 mL/min)

Penicillin G ben-
zathine (Bicillin©
L-A)

Infectious Diseases
For streptococcal N/A 1.2 million units IM N/A N/A 25,000–50,000 units/ 1.2 million units IM for
pharyngitis for 1 dose kg IM as a single dose 1 dose
or
If < 27 kg: 300,000–
600,000 units as a
single dose
or
If ≥ 27 kg: 0.9 million
units as a single
dose
Prophylaxis for N/A 1.2 million units IM N/A N/A 25,000–50,000 units/ 1.2 million units IM
rheumatic fever q 3–4 wk kg IM q 3–4 wk q 3–4 wk
For early syphilis N/A 2.4 million units IM N/A N/A 50,000 units/kg IM 2.4 million units IM for
for 1 dose for 1 dose 1 dose
For late syphilis N/A 2.4 million units N/A N/A 50,000 units/kg IM in 2.4 million units IM for
(excluding IM/wk for 3 wk 3 doses 1 wk apart 1 dose
neurosyphilis)
Penicillin G N/A 0.3–0.6 million units N/A N/A 25,000–50,000 units/ 0.3 to 0.6 million units
procaine IM q 12 h kg IM q 24 h IM q 12 h
(IM only) or
12,500–25,000 units/
kg IM q 12 h
Piperacillin N/A 3 g IV q 4–6 h 3 g IV q 4 h N/A 50–75 mg/kg IV q 6 h 3–4 g IV q 12 h
(1.9 mEq Na/g) or
33.3–50 mg/kg IV
3/11/11 10:34 AM

q4h
Table continues on the following page.
7034_11MM19_129_156_INF.indd 1191

Table 132–3. USUAL DOSES OF COMMONLY PRESCRIBED ANTIBIOTICS (Continued )

PEDIATRIC
ADULT DOSE (AGE > 1 MO) DOSE
DOSE IN RENAL
SERIOUS FAILUREa (CrCl
DRUG ORAL PARENTERAL INFECTIONS ORAL PARENTERAL < 10 mL/min)

Piperacillin/tazo- N/A 3.375 g IV q 4–6 h 3.375 g IV q 4 h N/A 80 mg/kg IV q 8 h 2.25 g IV q 8 h to 4.5 g

bactam (2.25 g = IV q 12 h
2.0 g piperacillin +
0.25 g tazobactam)
Ticarcillin N/A 3 g IV q 4–6 h 3 g IV q 4 h N/A If < 60 kg: 50 mg/kg 1–2 g IV q 12 h
(5.2 mEq Na/g) IV q 4–6 h
Ticarcillin/clavu- N/A 3.1 g IV q 4–6 h 3.1 g IV q 4 h N/A If < 60 kg: 50 mg/kg 2 g IV q 12 h

CHAPTER 132
lanate (3.1 g = 3 g IV (based on ticar-
ticarcillin + 0.1 g cillin component)
clavulanic acid) q 4–6 h
Other β-lactams
Aztreonam N/A 1–2 g IV q 2 g IV q 6 h N/A 30–40 mg/kg IV 0.5 g IV q 8 h
6–12 h q 6–8 h

Bacteria and Antibacterial Drugs

Ertapenem N/A 1 g IV q 24 h 1 g IV q 24 h N/A N/A 0.5 g IV q 24 h
Imipenem N/A 0.5–1.0 g IV q 6 h 1 g IV q 6 h N/A For infants 4 wk to 0.125–0.25 g IV q 12 h
3 mo: 25 mg/kg IV (may increase risk of
q6h seizures)
For children > 3 mo:
15–25 mg/kg IV
q6h
Meropenem N/A 1.0 g IV q 8 h 1.0 g IV q 8 h N/A 20–40 mg/kg IV q 8 h 0.5 g IV q 24 h
For meningitis — 40 mg/kg IV q 8 h 40 mg/kg IV q 8 h N/A — 20 mg/kg IV q 24 h
Fluoroquinolonesd
Ciprofloxacin 0.5–0.75 g 0.2–0.4 g IV 0.4 g IV q 8 h 10–15 mg/kg IV 10–15 mg/kg IV 0.5–0.75 g po q 24 h

1191
q 12 h q 8–12 h q 12 h (in select q 12 h (in select or
3/11/11 10:34 AM

circumstances) circumstances) 0.2–0.4 g IV q 24 h

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7034_11MM19_129_156_INF.indd 1192

Table 132–3. USUAL DOSES OF COMMONLY PRESCRIBED ANTIBIOTICS (Continued )

1192
PEDIATRIC
ADULT DOSE (AGE > 1 MO) DOSE
DOSE IN RENAL

SECTION 11
SERIOUS FAILUREa (CrCl
DRUG ORAL PARENTERAL INFECTIONS ORAL PARENTERAL < 10 mL/min)

Extended-release 0.5 g q 24 h for N/A N/A N/A N/A N/A

for uncomplicated 3 days
cystitis

Infectious Diseases
Gemifloxacin 320 mg q 24 h N/A N/A N/A N/A 160 mg po q 24 h
Levofloxacin 0.25–0.75 g 0.25–0.75 0.75 g IV q 24 h N/A N/A 0.25–0.5 g po or IV
q 24 h IV g q 24 h q 48 h
Moxifloxacin 0.4 g q 24 h 0.4 g IV q 24 h 0.4 g IV q 24 h N/A N/A 0.4 g q 24 h po or IV
Norfloxacinb 0.4 g q 12 h N/A N/A N/A N/A 0.4 g po q 24 h
Ofloxacin 0.2–0.4 g q 12 h 0.4 g IV q 12 h 0.2–0.4 g IV q 12 h N/A N/A 0.1–0.2 g po or IV
q 24 h
Macrolides
Azithromycin 0.5 g on day 1, 0.5 g IV q 24 h 0.5 g IV q 24 h — N/A 0.5 g on day 1, then
then 0.25 g q 0.25 g po q 24 h for 4
24 h for 4 days days or 0.5 g IV q 24 h
For nongonococcal 1 g for 1 dose N/A N/A N/A N/A N/A
cervicitis and
urethritis
For traveler’s 1 g for 1 dose N/A N/A 5–10 mg/kg for N/A N/A
diarrhea 1 dose
For tonsillitis or N/A N/A N/A 12 mg/kg for 5 days N/A N/A
pharyngitis
For otitis media N/A N/A N/A 10 mg/kg on day 1, N/A N/A
or community- then 5 mg/kg once/day
acquired pneumonia on days 2–5
3/11/11 10:34 AM

Table continues on the following page.

7034_11MM19_129_156_INF.indd 1193

Table 132–3. USUAL DOSES OF COMMONLY PRESCRIBED ANTIBIOTICS (Continued )

PEDIATRIC
ADULT DOSE (AGE > 1 MO) DOSE
DOSE IN RENAL
SERIOUS FAILUREa (CrCl
DRUG ORAL PARENTERAL INFECTIONS ORAL PARENTERAL < 10 mL/min)

Clarithromycin 0.25–0.5 g q 12 h N/A N/A 7.5 mg/kg q 12 h N/A 0.25–0.5 g po q 24 h

Extended-re-
lease: 1 g q 24 h
Dirithromycin 0.5 g q 24 h N/A N/A N/A N/A 0.5 g po q 24 h
Erythromycin 0.25–0.5 g N/A N/A 10–16.6 mg/kg q 8 h N/A 0.25 g po q 6 h
baseb q6h or
7.5–12.5 mg/kg q 6 h

CHAPTER 132
Lactobionate N/A 0.5–1 g IV q 6 h 1 g IV q 6 h N/A 3.75–5.0 mg/kg IV 0.5 g IV q 6 h
q6h
Gluceptate N/A 0.5–1 g IV q 6 h 1 g IV q 6 h N/A 3.75–5.0 mg/kg IV 0.5 g IV q 6 h
q6h
For GI preoperative 1 g for N/A N/A 20 mg/kg for 3 doses N/A N/A
bowel preparation 3 doses

Bacteria and Antibacterial Drugs

Telithromycin 800 mg q 24 h N/A N/A N/A N/A 800 mg po q 24 h
Sulfonamides and trimethoprim
Sulfisoxazole 1.0 g q 6 h 25 mg/kg IV q 6 h (not N/A 30–37.5 mg/kg q 6 h N/A 1 g po q 12–24 h
available in US) or
20–25 mg/kg q 4 h
Sulfamethizole 0.5–1 g q 6–8 h N/A N/A 7.5–11.25 mg/kg q 6 h N/A N/A
Sulfamethoxazole 1 g q 8–12 h N/A N/A 25–30 mg/kg q 12 h N/A 1 g po q 24 h
Trimethoprim 0.1 g q 12 h N/A N/A 2 mg/kg q 12 h for N/A 0.1 g po q 24 h
or 10 days for UTI
0.2 g q 24 h
Trimethoprim/ 0.16/0.8 g q 12 h 3–5 mg TMP/kg IV 5 mg TMP/kg IV 3–6 mg TMP/kg 3–6 mg TMP/kg IV (Not recommended if

1193
sulfamethoxazolee q 6–8 h q6h q 12 h q 12 h other alternatives are
3/11/11 10:34 AM

available)

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7034_11MM19_129_156_INF.indd 1194

Table 132–3. USUAL DOSES OF COMMONLY PRESCRIBED ANTIBIOTICS (Continued )

1194
PEDIATRIC
ADULT DOSE (AGE > 1 MO) DOSE
DOSE IN RENAL

SECTION 11
SERIOUS FAILUREa (CrCl
DRUG ORAL PARENTERAL INFECTIONS ORAL PARENTERAL < 10 mL/min)
For Pneumocystis 0.32/1.6 g q 8 h 5 mg TMP/kg IV 5 mg TMP/kg IV 5–6.6 mg TMP/kg q 8 h 5–6.6 mg TMP/kg IV If essential, 5 mg
jirovecii pneumo- for 21 days q 8 h for 21 days q 6–8 h or q8h TMP/kg IV q 24 h
niae 3.75–5 mg TMP/kg q 6 h or or

Infectious Diseases
3.75–5 mg TMP/kg 1.25 mg TMP/kg IV
IV q 6 h q6h
Tetracyclines
Doxycycline 0.1 g q 12 h 0.1 g IV q 12 h 0.1 mg IV q 12 h Age > 8 yr: 2–4 mg/kg Age > 8 yr: 2–4 mg/ 0.1 g IV or po q 12 h
q 24 h kg IV q 24 h
or or
1–2 mg/kg q 12 h 1–2 mg/kg IV q 12 h
Minocycline 0.1 g q 12 h 0.1 g IV q 12 h 0.1 g IV q 12 h N/A N/A 0.1 g IV or po q 12 h
Tetracyclineb 0.25–0.5 g N/A N/A Age > 8 yr: 6.25–12.5 N/A Doxycycline used
q6h mg/kg q 6 h instead
Tigecycline N/A 100 mg, then 50 mg Same as adult dose N/A N/A Same as adult dose
(25 mg for severe
hepatic dysfunc-
tion) IV q 12 hr
Others
Clindamycin 0.15–0.45 g 0.6 g IV q 6 h to 0.9 0.9 g IV q 8 h 2.6–6.6 mg/kg q 8 h 6.6–13.2 mg/kg IV 0.15–0.45 g po q 6 h
q6h IV g q 8 h or q8h or
2–5 mg/kg q 6 h or 0.6–0.9 g IV q 6–8 h
5–10 mg/kg IV q 6 h
Chloramphenicol 0.25–1 g q 6 h 0.25–1.0 g IV q 6 h 1 g IV q 6 h N/A 12.5–18.75 mg/kg 0.25–1.0 g IV q 6 h
IV q 6 h
For meningitis N/A 12.5 mg/kg q 6 h 12.5 mg/kg IV N/A 18.75–25 mg/kg IV 12.5 mg/kg IV q 6 h
(maximum: 4 g/day) q 6 h (maximum: q6h (maximum: 4 g/day)
4 g/day)
3/11/11 10:34 AM

Daptomycin N/A 4 mg/kg IV q 24 h 4 mg/kg IV q 24 h N/A N/A 4 mg/kg IV q 48 h

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7034_11MM19_129_156_INF.indd 1195

Table 132–3. USUAL DOSES OF COMMONLY PRESCRIBED ANTIBIOTICS (Continued )

PEDIATRIC
ADULT DOSE (AGE > 1 MO) DOSE
DOSE IN RENAL
SERIOUS FAILUREa (CrCl
DRUG ORAL PARENTERAL INFECTIONS ORAL PARENTERAL < 10 mL/min)

Linezolid 0.6 g q 12 h 0.6 g IV q 12 h 0.6 g IV q 12 h 10 mg/kg q 8 h 10 mg/kg IV q 8 h 0.6 g IV or po q 12 h

Metronidazole
For anaerobic 7.5 mg/kg q 6 h 7.5 mg/kg IV 7.5 mg/kg IV 7.5 mg/kg q 6 h 7.5 mg/kg IV q 6 h 3.75 mg/kg IV or po
infection (not to exceed q 6 h (not to q 6 h (not to q 6 h (not to exceed
4 g/day) exceed 4 g/day) exceed 4 g/day) 2 g/day)
For trichomoniasis 2 g for 1 dose N/A N/A N/A N/A N/A
or

CHAPTER 132
0.5 g q 12 h for
7 days
For Clostridium 0.5 g q 6–8 h for 500 mg IV q 6–8 h 500 mg IV q 6 h 7.5 mg/kg q 8 h 7.5 mg/kg IV q 6 h 250 mg po or IV q 8 h
difficile–induced 10–14 days
diarrhea (pseudo-
membranous coli-
tis)

Bacteria and Antibacterial Drugs

For amebiasis 0.5–0.75 g q 8 h 0.75 g IV q 8 h for 0.75 g IV q 8 h 11.6–16.6 mg/kg 11.6–16.6 mg/kg N/A
for 10 days fol- 10 days followed for 10 days q 8 h for 7–10 days IV q 8 h for 7–10
lowed by paro- by paromomycin followed by paro- days
momycin po po 0.5 g q 8 h for momycin po 0.5 g q
0.5 g q 8 h for 7 days 8 h for 7 days
7 days
For giardiasis 0.25 g q 6–8 h N/A N/A 5 mg/kg q 6–8 h N/A N/A
for 5–7 days for 5 days
Nitrofurantoin 50–100 mg N/A N/A 1.25–1.75 mg/kg N/A Not recommended
macrocrystals q6h q6h
Nitrofurantoin 100 mg q 12 h N/A N/A N/A N/A N/A
monohydrate/
3/11/11 10:34 AM

1195
macrocrystals

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7034_11MM19_129_156_INF.indd 1196

Table 132–3. USUAL DOSES OF COMMONLY PRESCRIBED ANTIBIOTICS (Continued )

1196
PEDIATRIC
ADULT DOSE (AGE > 1 MO) DOSE
DOSE IN RENAL

SECTION 11
SERIOUS FAILUREa (CrCl
DRUG ORAL PARENTERAL INFECTIONS ORAL PARENTERAL < 10 mL/min)

Quinupristin/ N/A 7.5 mg/kg IV 7.5 mg/kg IV q 8 h N/A 7.5 mg/kg IV q 12 h 7.5 mg/kg IV q 8–12 h
dalfopristin q 8–12 h for complicated skin
or skin structure

Infectious Diseases
infection
or
7.5 mg/kg q 8 h for
serious infections
Rifampinb
For TB 0.6 g q 24 h 0.6 g IV q 24 h N/A 5–10 mg/kg q 12 h 10–20 mg/kg IV 0.3–0.6 g IV or po
or q 24 h q 24 h
10–20 mg/kg q 24 h
For meningococcal 0.6 g q 12 h for N/A N/A Age ≥ 1 mo: 10 mg/kg N/A 0.6 g po q 12 h for
exposure 4 doses q 12 h for 2 days 4 doses
Age < 1 mo: 5 mg/kg
q 12 h for 2 days
For Haemophilus 20 mg/kg q 24 h N/A N/A 20 mg/kg q 24 h for N/A 20 mg/kg q 24 h for
influenzae for 4 days (not 4 days 4 days (not to exceed
exposure to exceed 600 Age < 1 mo: 10 mg/kg 600 mg q 24 h)
mg q 24 h) q 24 h for 4 days
For staphylococcal 0.3 g q 8 h 0.3 g IV q 8 h 0.3 g IV q 8 h — — 0.3 g IV or po q 8 h
infections (used or or or or
with a penicillin, 0.6–0.9 g q 24 h 0.6–0.9 g IV q 24 h 0.6–0.9 g IV q 24 h 0.6–0.9 g IV or po q 24 h
cephalosporin, or
vancomycin)
Spectinomycin N/A 2 g IM for 1 dose N/A N/A N/A 2 g IM for 1 dose
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Table continues on the following page.

7034_11MM19_129_156_INF.indd 1197

Table 132–3. USUAL DOSES OF COMMONLY PRESCRIBED ANTIBIOTICS (Continued )

PEDIATRIC
ADULT DOSE (AGE > 1 MO) DOSE
DOSE IN RENAL
SERIOUS FAILUREa (CrCl
DRUG ORAL PARENTERAL INFECTIONS ORAL PARENTERAL < 10 mL/min)

Vancomycin 125 mg q 6 h 15 mg/kg q 12 h 15 mg/kg IV q 12 h N/A 13 mg/kg IV q 8 h 0.5–1.0 g IV q wk

(only effective (often 1 g q 12) or
for C. difficile– 10 mg/kg q 6 h
induced
diarrhea
For meningitis N/A 1 g IV q 8 h 1 g IV q 8 h N/A 15 mg/kg IV q 6 h 15 mg/kg IV q wk
or or
1.5 g IV q 12 hf 1.5 g IV q 12 h

CHAPTER 132
aInitial loading dose should be equivalent to the usual dose for patients with normal renal function, followed by a dose adjusted for renal failure. Dosing adjustments
of aminoglycosides should be assisted by measuring peak (drawn 1 h after the start of a 30-min IV infusion) and trough (drawn 30 min before next dose) serum levels.
b
Rate or extent of absorption is decreased when the drug is taken with food.
cDosage should not exceed that for adults.
d
These drugs are generally avoided in children.
eDose is based on TMP.

Bacteria and Antibacterial Drugs

fIn addition, intrathecal or intraventricular vancomycin 10–20 mg/day may be necessary, and dose may need to be adjusted to achieve trough CSF levels of 10–20
µg/mL.
N/A = not applicable; TMP = trimethoprim.

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