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Muhammad Saquib Qureshi

PhD (Fellow) University of Karachi


+92 333 2243031
drsaquibqureshi@gmail.com
ACE Inhibitrs are among the most widely used medicines in cardiovascular
pharmacology
ACE Inhibitors are used in the treatment of
Hypertension
Ischemic heart disease
Chronic heart failure
Diabetic nephropathy
ACE inhibitors include
Ramipril
Lisinopril
Perindopril
Mechanism of action of ACE inhibitors
Side effects
ACE inhibitors are associated with their own range of potential side
effects.
Hypotension: a notable consequence of its mechanism of action.
Patients typically experience worsened hypotension during the first
dose, the effect tapering off thereafter.
Persistant dry cough: attributable to the accumulation of kinins in
lungs.
Hyperkalemia: ACE inhibitors promote retention of potassium ions.
Patients potassium levels should be monitered.
Clinical considerations
When we talk about the clinical pharmacology of ACE inhibitors, we need to
think about the following factors
1. The ACE inhibitors should be used with caution in patients with renal
impairment.
2. For chronic kidney disease lower doses should be used and their effects
monitered.
3. ACE inhibitors are classified as pregnancy catergory D, meaning there is a
positive evidence of risk.
4. Potassium supplements with ACE inhibitors are used with cautions.
5. Risk of renal failure increases when ACE inhibitors taken with NSAIDs
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