Atorvastatin Cardiovascular Agent Adjunct to diet for the -Constipation Absorption: Rapidly -Monitor for therapeutic
reduction of LDL -Diarrhea absorbed but undergoes effectiveness which is
cholesterol and extensive indicated by reduction
triglycerides in patients -Nausea gastrointestinal and in the level of LDL- C.
with primary -Fatigue hepatic metabolism -Assess for muscle pain,
hypercholesterolemia resulting in 14% tenderness, or
and mixed dyslipidemia -Gas bioavailability. weakness. If present,
-Heartburn Protein Binding: 98% monitor CPK level.
-Headache Metabolism and -Instruct patient to
-Mild muscle pain Excretion: Extensively notify health care
metabolized by the professional if
-Muscle wasting and
liver, most during first unexplained muscle
muscle breakdown
pass; excreted in bile pain, tenderness, or
-Confusion or memory and feces. 2% excreted weakness occurs,
problems unchanged by the especially if
-Fever kidneys. 2 metabolites accompanied by fever
have lipid-lowering or malaise.
-Dark urine activity. -Advise patient that this
-Increased thirst or Half-life: 14 hr medication should be
hunger used in conjuction with
Dosage Mechanism of Action Contraindication Drug Interaction
-Drowsiness diet restriction.
40 mg, 1 tab OD Hypersensitivity to Digoxin,
atorvastatin, myopathy, -Loss of appetite Norethindrone and -Emphasize the
active liver disease, Ethinyl, Estradiol, importance of follow-up
-Jaundice
unexplained persistent Erythromycin, exams to determine
transaminase elevation Cyclosporine, effectiveness and to
Delaviradine, monitor for side effects.
Gemfibrozil, Niacin,
Clofibrate and
Nelfinavir.
Drug Analysis
marrow maturation
Drug Analysis