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IAS Delhi Medical Science Test 2 (Pharmacology & Pathology) 20 Jan 2019

Salient Features:
1. Test series under the guidance of UPSC toppers.
2. The focus will be on coverage of syllabus.
3. To give personal attention, only 20 candidates will be admitted.
4. The question papers will be set as per the latest trend of UPSC Examination.
5. Approach for answers for each test.
6. Test series available online as well as offline mode.

For admission please click the below link:


http://iasdelhi.org/application-form-for-test-series/

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IAS Delhi Medical Science Test 2 (Pharmacology & Pathology) 20 Jan 2019

Section A

Q1)

a) What is mode of action of atenolol in lowering blood pressure (10 M)


b) Describe the spectrum of antiamoebic action of metronidazole and side
effects & contraindications (10 M)
c) What are common bacterial Nosocomial infections? Describe antibiotics
used to treat staph-Aureus infection. (10 M)
d) Name alkaloids of opium. Enumerate contraindications of morphine as
analgesic. (10 M)
e) Mention advantages of dihydropyridines in the treatment of angina
pectoris. (10 M)

Q2)

A.
i. Describe mechanism of action, uses and side effects of cyclosporine
as immunosuppressants. (10 M)
ii. Explain Artemisinin based combination therapy for uncomplicated
falciparum malaria. (10 M)
B. Describe any 4 types of helminthiasis. Give drug of choice for each
explaining mechanism of action of that drug. (20 M)
C. Describe doses & use of following drugs. (10 M)
i. Chloramphenicol
ii. Atorvastatin

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IAS Delhi Medical Science Test 2 (Pharmacology & Pathology) 20 Jan 2019

iii. Rosiglitazone
iv. Drotaverine

Q3)
A. Compare and contrast following drugs (Any two) (10 M)
i. Enalapril & Losartan
ii. Aspirin & paracetamol
iii. Nitroglycerin & Digoxin
B.
i. Describe antibacterial spectrum of 3rd generation cephalosporin. Give
mechanism of action of cefepime. (10 M)
ii. Describe treatment of urinary tract infections. (10 M)
C. Describe mechanism of action, interaction & adverse effects of metformin
(20 M)

Q4)

A.
i. Lower molecular weight heparin preparations are preferred
anticoagulant over regular heparin. Why? (10 M)
ii. Thiazide Diuretics are first line drugs in treatment of essential
hypertension. Why? (10 M)
B.

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IAS Delhi Medical Science Test 2 (Pharmacology & Pathology) 20 Jan 2019

i. Discuss treatment of vaginal candidiasis. (10 M)


ii. Enumerate drugs used in treatment of Leishmaniasis. (5 M)
C.
i. What are antiviral drugs? Enumerate drugs used in treatment of
chickenpox. (5 M)
ii. Describe role of streptokinase in myocardial infarction. (5 M)
iii. Enumerate Topical antibacterial antibiotics. Write note on
Framycetin. (5 M)

Section B

Q5)

a) Enumerate chemical mediators of acute inflammation. Give their


mechanism of action. (3+7=10)
b) What is the difference between Nephritic Syndrome and Nephrotic
Syndrome? (10 M)
c) What are the morphological changes and complications in MI? (10 M)
d) Enumerate the various etiological agents causing neoplasia. Discuss the
mechanism of viral carcinogenesis. (10 M)
e) What are the possible contributing factors in the genesis of
Bronchogenic carcinoma? Give gross, microscopic features and spread
of squamous cell carcinoma of lung. (10 M)

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IAS Delhi Medical Science Test 2 (Pharmacology & Pathology) 20 Jan 2019

Q6)

A. Write pathogenesis and histopathology of rheumatic heart disease. (20 M)


B. Discuss etiology and pathology of membranous glomerulonephritis. (15 M)
C. What is intraepithelial neoplasia (CIS)? Classify carcinoma of cervix. Give
pathology of it. (15 M)

Q7)

A. Classify leukemia. How will you differentiate between ALL and CML. Give
clinical features and blood pictures of both. What is role of genetic marker
in diagnosis of CML? (3+7+7+3=20 M)
B. Define granuloma. Discuss Morphological forms of Pulmonary Tuberculosis.
(15 M)
C. Define peptic ulcer. Write in brief about its pathogenesis and
histopathology. (15 M)

Q8)

A.
i. Write a brief note on diabetic nephropathy. Discuss pathophysiology
of type 2 diabetes milleteus. (10 M)
ii. What are the possible contributing factors in pathogenesis of
carcinoma of breast? Describe histopathology of different types of
breast carcinoma. (10 M)

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IAS Delhi Medical Science Test 2 (Pharmacology & Pathology) 20 Jan 2019

B. Define cirrhosis of liver. Classify cirrhotic conditions of liver. Discuss the


etiopathogenesis and pathology of primary biliary cirrhosis. (15 M)
C. What are the etiological factors in the genesis of oral cancer? Enumerate
the malignant lesions that are likely to affect the oral cavity. Briefly describe
their histopathological features. (15 M)

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