FK
LECTURERS
1. Fransiska Kurniawan
(fransiskakurniawan@yahoo.com)
MID TEST
2. Hubbi N. M.
3. Deden Indra
FINAL TEST
4. Rika Rendrika
FK
REFERENCES
MEDICINAL CHEMISTRY
• Medicinal Chemistry
(IUPAC)
Field that concerns about
the discovery,
the development,
the identification and
the interpretation of the mode
of action of biologically active
compounds at the molecular
level
FK
• Compound
Interaction and target
Affect
Phy/Bio • Influence
Process
Increase NO NEW
FUNCTION !!
and reduce
function
FK
MOLECULAR LEVEL ?
J.C. Kendrew: the first protein model (myoglobin)
MOLECULAR LEVEL ?
MOLECULAR LEVEL ?
MEDICINAL CHEMISTRY
Pharmacology
Organic Biology
Chemistry
Medicinal
Biochemistry
Chemistry
Mathematics
Computer and
Medicine Bioinformatic
Toxicology
FK
MEDICINES VS DRUGS
Medicines :
the substances used to treat diseases
Drugs :
are the molecules used as medicines or
as components in medicines to
diagnose, cure, mitigate, treat, or prevent
disease
FK
BAD GOOD
• Toxic
• Side effect • Effective
• Addictive • Safe
• No side effect
• Easy to take
FK
A glimpse of History :
From OPIUM preparation to the isolation of MORPHINE
Papaver somniferum
MORPHINE
FK
HEROIN
FK
MORPHINE TO HEROIN
FK
CURARE
NOW
To make the
muscle relax
during surgical
operation
FK
CAFFEINE
Stimulant
good
CAFFEINE
bad
Addictive
FK
NICOTINE
FK
DRUGS
“ EvErything is poison,
nothing is poison
it is thE dosE that makEs thE poison “
FK
drugs
FK
Paul Ehrlich :
Test various azo dyes were effective agents against
trypanosomiasis (“ sleeping sickness ”) in mice;
however, none was effective in man.
He began an exhaustive search for “ magic bullet ” that able to
kill the microbe but not the person when killing the
disease
Method : SAR
FK
Identify disease
Find a drug effective
against disease protein
(2-5 years)
Scale-up
Isolate protein
involved in
disease (2-5 years)
Human clinical trials
Preclinical testing (2-10 years)
(1-3 years)
Formulation
FDA approval
(2-3 years)
FK
DRUG DISCOVERY
FK
ASSIGNMENT
ASSIGNMENT
EXAMPLE OF JOURNAL