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Endocrine UDOS Course

Learning Issue Writeup


Eric’s Write up

Identifying information
Case: Endocrine
Day and Date: 2/12/2018
Learning Issue Writeup Author: Eric Medrano

Learning Issue Question

What is the mechanism behind the Wolff–Chaikoff effect


This is a background question on the Wolff–Chaikoff effect

Information Searching Process

The first website that I looked at was up to date. I think this was a great way to start out because
primary articles are very good sources of information due to them being peer reviewed. The first article I
found was very beneficial because it helped give me an overview of the Wolff Chaikoff effect and how it
can inhibit I looked into PubMed and found the same research paper on the Wolff effect performed on
rats.

Reflecting on my search methods, I think that this was a great source because of its high citation impact
These papers all appear in paper reviewed journals are reliable resources. My information comes from
my primary article that I cited because it’s a more reliable source than up to date which is a compilation
of other primary articles.

Information Summary
In this paper by Eng PH, et.al, they discussed the mechanism behind the wolff=Chaikoff effect. They noted
through previous papers that the wolff effect works by inhibiting thyroid production in the presence of
excess iodine. Through a 6 day experiment on rats, they found that that the primary mechanism in a
decrease in Thyroid peroxidase inhibition due to a decrease in the mRNA associated with that protein.
This decrease in thyroid peroxidase leads to inhibition of the oxidation, organification, and coupling
reaction of iodine in the pathway to become T3/T4.
Figure 1- Inhibition of TPO in 3oxidation, organification and coupling of iodine, Picture from
http://www.pathwaymedicine.org/thyroid-hormone-synthesis

Bibliography

Eng PH, Cardona GR, Fang SL, Previti M, Alex S, Carrasco N, Chin WW, Braverman LE. Escape from the
acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger
ribonucleic acid and protein. Endocrinology. 1999 Aug 1;140(8):3404-10.

http://www.pathwaymedicine.org/thyroid-hormone-synthesis