Anda di halaman 1dari 46


Science of Diet & Exercise

From the Editors of Scientific American

Cover Image: malerapaso/Getty Images

Letters to the Editor

Scientific American
One New York Plaza
Suite 4500
New York, NY 10004-1562

Copyright © 2018 Scientific American, a division of Nature America, Inc.

Scientific American is a registered trademark of Nature America, Inc.
All rights reserved.

Published by Scientific American

ISBN: 978-1-2501-2158-5


From the Editors of Scientific American

Table of Contents
The Science of Diet & Exercise
by Karin Tucker

Breaking Biology: New Truths in Diet & Exercise

The Exercise Paradox
by Herman Pontzer

The Messy Truth about Weight Loss
by Susan B. Roberts and Sai Krupa Das

The “True” Human Diet
by Peter Ungar

Mind over Meal: Weight-Loss Surgery and the Gut-Brain Connection
by Bret Stetka

Behavioral Intervention

Don’t Diet!
by Charlotte N. Markey

Behavior: The Additional Key to Weight-Loss
by David H. Freedman

Mental Floss: Your Brain on Exercise

Head Strong
by Ferris Jabr

Take 2 Hikes and Call Me in the Morning
by Nathaniel P. Morris

The Science of Diet & Exercise
“It is easier to change a man's religion than to change his diet.”
― Margaret Mead

Each year, Americans spend more than $60 billion to achieve their weight loss goals.1 On Amazon alone, a
search for “diet” yields about 202,000 products, 193,000 of which are books. Search for “exercise” and you’ll find
a whopping 841,000 products, 194,000 of which are books. It’s enough to make your head spin.
What should be clear is that the solution isn’t simple. For years, the weight loss party line was one of basic math:
burn more calories than you consume. Now, new evidence from Susan B. Roberts and Sai Krupa Das shows that
the kinds of foods you eat are as important as how much you eat. This article and the seven others in this collection
discuss the most recent research that’s upending conventional wisdom on weight loss and suggest ways to put that
science to work for you.

For example, it also seems inescapably logical that physically active people burn more calories, but studies of
hunter-gatherers refute this notion. Anthropologist Herman Pontzer explores how energy expenditure (caloric burn)
stays virtually constant among humans, regardless of the level of physical activity, indicating that exercise alone
won’t help reach weight loss goals. The remaining selections take a look at the efficacy of the popular Paleolithic
Diet and how weight-loss surgery impacts gut-brain communication in unexpected ways.

The mind’s role is further explored in “Don’t Diet,” where psychologist Charlotte N. Markey lays out guidelines
for weight-loss that help to avoid common psychological pitfalls of dieting. Then in “Behavior: The Additional
Key to Weight-Loss,” David H. Freeman shows how the complexities of obesity can be circumvented by focusing
on behavior in the same manner as treating stuttering or alcoholism. This is followed by two selections that take a
look at how exercise and outdoor activity are effective treatments for depression and support increased overall
mental health.

Sorting out the details of the metabolic process and how weight management works is far more complicated than
anyone initially thought. Simple fixes and one-size-fits-all advice has never worked, and often leads to cycles of
failure, self-blame and depression. Now that evidence is starting to refute common dogmas surrounding weight
loss, it opens doors for new approaches, both physical and mental, some of which can be applied to how we think
about diet and exercise today.

- Karin Tucker
Book Editor

1. U.S. News & World Report. “The Heavy Price of Losing Weight,” by Geoff Williams.
Jan. 2, 2013.

Breaking Biology: New Truths in Diet & Exercise

The Exercise Paradox
by Herman Pontzer

Still no giraffe. Four of us had been walking half the day, tracking a wounded giraffe that Mwasad, a Hadza man
in his late 30s, shot the evening before. He hit it in the base of the neck from about 25 yards with a steel-tipped,
wood arrow smeared with powerful, homemade poison. Hadza are traditional hunter-gatherers who live off of wild
plants and animals in the dry savanna wilder ness of northern Tanzania. They know the landscape and its residents
better than you know your local Trader Joe’s. Mwasad had let the giraffe run to give the poison time to work,
hoping to find it dead in the morning. An animal that size would feed his family and his camp for a week- but only
if he could locate it.

Mwasad led our party—Dave Raichlen from the University of Arizona, a 12-year-old Hadza boy named Neje
and me—out of camp just after daybreak. Dave and I were of little use in this endeavor. Mwasad had invited us
along as a friendly gesture and for the extra help to carry the butchered animal back to camp should our search
effort succeed. As anthropologists who study human ecology and evolution, we jumped at the opportunity to tag
along—Hadza men’s tracking abilities are legendary. It certainly beat the prospect of a long day in camp spent
fiddling with research equipment.
We walked hard for an hour through a pathless, rolling sea of golden, waist-high grass, dotted with brush and
thorny acacia trees, directly to the bloody patch where the giraffe was struck. That bit of navigation in itself was
quite a trick, like someone leading you to the middle of a 1,000-acre wheat field to show you where he had once
dropped a toothpick and then nonchalantly reaching down to pick it up. Hour on hour, tracking the wounded
animal under a relentless sun ensued as we followed ever more tenuous signs.

Still no giraffe. At least I had water. We sat in the shade of some bushes just after midday, taking a break while
Mwasad pondered where the injured creature might head. I had a quart or so left—enough, I figured, to get through
the heat of the afternoon. Mwasad, however, had not brought any water with him, as is typical of the Hadza. As we
packed up to restart the search, I offered him a drink. Mwasad gave me a sideways look, smiled and proceeded to
drink the entire bottle in one long pull. When he finished, he casually handed me the empty bottle.

It was karma. Dave and I, along with anthropologist Brian Wood from Yale University, had spent the past month
living with the Hadza, conducting the first direct measurements of daily energy expenditure in a hunter-gatherer
population. We enlisted a couple of dozen Hadza women and men, Mwasad among them, to drink small, incredibly
expensive bottles of water enriched in two rare isotopes, deuterium and oxygen 18. Analyzing the concentration of
those isotopes in urine samples from each participant would allow us to calculate their body’s daily rate of carbon
dioxide production and thus their daily energy expenditure. This approach, known as the doubly labeled water
method, is the gold standard in public health for measuring the calories burned each day during normal daily life. It
is straightforward, completely safe and accurate, but it requires that participants drink every last drop of the
enriched water. We had taken pains to make clear that they must not spill, that they had to finish the dose
completely. Mwasad seemed to have taken that message to heart.

Mwasad’s sly joking aside, my colleagues and I have learned a lot about how the human body burns calories
through our work with the Hadza. Together with findings from investigators who study other populations, our
research has revealed some surprising insights into human metabolism. Our data indicate that, contrary to received
wisdom, humans tend to burn the same number of calories regardless of how physically active they are. Yet we
have evolved to burn considerably more calories than our primate cousins do. These results help to explain two

puzzles that might seem disparate at first but are, in fact, related: first, why exercise generally fails to aid weight
loss and, second, how some of humanity’s unique traits arose.

The Calorie Economy

Researchers who are interested in human evolution and ecology often focus on energy expenditure because
energy is central to everything in biology. One can learn a lot about any species by measuring its metabolism: life
is essentially a game of turning energy into kids, and every trait is tuned by natural selection to maximize the
evolutionary return on each calorie spent. Ideally, the study population lives in the same environments in which the
species originally evolved, where the same ecological pressures that shaped its biology are still at work. That is
difficult to achieve with human subjects because most people are divorced from the daily work of acquiring food
from a wild landscape. For nearly all the past two million years, humans and our ancestors have been living and
evolving as hunter-gatherers. Farming only got going about 10,000 years ago; industrialized cities and modern
technology are only a few generations old. Populations such as the Hadza, one of the last hunter-gatherer
populations left in the world, are key to understanding how our bodies evolved and functioned before cows, cars
and computers.
Life for the Hadza is physically demanding. Each morning the women leave the grass huts of camp in small
groups, some carrying infants on their back in a wrap, foraging for wild berries or other edibles. Wild tubers are a
staple of the Hadza diet, and women can spend hours digging them out of the rocky ground with sticks. Men cover
miles each day hunting with bows and arrows they make themselves. When game is scarce, they use simple
hatchets to chop into tree limbs, often 40 feet up in the canopy, to harvest wild honey. Even the children contribute,
hauling buckets of water back from the nearest watering hole, sometimes a mile or more from camp. In the late
afternoon, folks wend their way back to camp, sitting on the ground and talking around small cooking fires, sharing
the day’s returns and tending to the kids. Days roll along like this through dry and wet seasons, ad millennium.

But forget any romantic notions of some lost Eden. Hunting and gathering is cerebral and risky, a high-stakes
game in which the currency is calories and going bust means death. Men such as Mwasad spend hundreds of
calories a day hunting and tracking, a gamble that they hope will pay off in game. Savvy is just as critical as
stamina. Whereas other predators can rely on their speed and strength to obtain prey, humans have to outthink their
quarry, considering their behavioral tendencies and scouring the landscape for signs of game. Still, Hadza men land
big game like giraffes only about once a month. They would starve if Hadza women were not executing an equally
sophisticated, complementary strategy, using their encyclopedic knowledge of local plant life to bring home a
reliable bounty every day. This complex, cooperative foraging is what made humans so incredibly successful and is
the core of what makes us unique.

Researchers in public health and human evolution have long assumed that our hunter-gatherer ancestors burned
more calories than people in cities and towns do today. Given how physically hard folks such as the Hadza work, it
seems impossible to imagine otherwise. Many in public health go so far as to argue that this reduction in daily
energy expenditure is behind the global obesity pandemic in the developed world, with all those unburned calories
slowly accumulating as fat. One of our motivations for measuring Hadza metabolism was to determine the size of
this energy shortfall and see just how deficient we Westerners were in our daily expenditure. Back home in the
U.S. after a hot and dusty field season, I lovingly packed the vials of Hadza urine on dry ice and sent them away to
the Baylor College of Medicine, home of one of the best doubly labeled water laboratories in the country,
imagining the whopping calorie totals they would reveal.

But a funny thing happened on the way to the isotope ratio mass spectrometer. When the analyses came back
from Baylor, the Hadza looked like everyone else. Hadza men ate and burned about 2,600 calories a day, Hadza
women about 1,900 calories a day—the same as adults in the U.S. or Europe. We looked at the data every way
imaginable, accounting for effects of body size, fat percentage, age and sex. No difference. How was it possible?
What were we missing? What else were we getting wrong about human biology and evolution?

Lies My Fitbit Told Me

It seems so obvious and inescapable that physically active people burn more calories that we accept this
paradigm without much critical reflection or experimental evidence. But since the 1980s and 1990s, with the

advent of the doubly labeled water method, the empirical data have often challenged the conventional wisdom in
public health and nutrition. The Hadza result, strange as it seemed, was not some thunderbolt from the blue but
more like the first cold drop of water down your neck from a rain that had been building, ignored, for years.

The earliest doubly labeled water studies among traditional farmers in Guatemala, the Gambia and Bolivia
showed their energy expenditures were broadly similar to those of city dwellers. In a study published in 2008, Amy
Luke, a researcher in public health at Loyola University Chicago, took this work a step further, comparing energy
expenditure and physical activity in rural Nigerian women with that in African-American women in Chicago. Like
the Hadza study, hers found no differences in daily energy expenditure between populations, despite large
differences in activity levels. Following up on that work, Lara Dugas, also at Loyola, along with Luke and others,
analyzed data from 98 studies around the globe and showed that populations coddled by the modern conveniences
of the developed world have similar energy expenditures to those in less developed countries, with more physically
demanding lives.

Humans are not the only species with a fixed rate of energy expenditure. On the heels of the Hadza study, I
piloted a large collaborative effort to measure daily energy expenditure among primates, the group of mammals
that includes monkeys, apes, lemurs and us. We found that captive primates living in labs and zoos expend the
same number of calories each day as those in the wild, despite obvious differences in physical activity. In 2013
Australian researchers found similar energy expenditures in sheep and kangaroos kept penned or allowed to roam
free. And in 2015 a Chinese team reported similar energy expenditures for giant pandas in zoos and in the wild.
For a more granular look, comparing individuals instead of population averages, I recently joined Luke and her
team, including Dugas, to examine activity and energy expenditure in a large, multiyear analysis known as the
Modeling the Epidemiological Transition Study (METS). More than 300 participants wore accelerometers similar
to a Fitbit or other fitness tracker 24 hours a day for an entire week while their daily energy expenditure was
measured with doubly labeled water. We found that daily physical activity, tracked by the accelerometers, was
only weakly related to metabolism. On average, couch potatoes tended to spend about 200 fewer calories each day
than people who were moderately active: the kind of folks who get some exercise during the week and make a
point to take the stairs. But more important, energy expenditure plateaued at higher activity levels: people with the
most intensely active daily lives burned the same number of calories each day as those with moderately active
lives. The same phenomenon keeping Hadza energy expenditure in line with that of other populations was evident
among individuals in the study.

How does the body adjust to higher activity levels to keep daily energy expenditure in check? How can the
Hadza spend hundreds of calories a day on activity yet burn the same total number of calories a day as
comparatively sedentary people in the U.S. and Europe? We are still not sure, but the cost of activity per se is not
changing: we know, for example, that Hadza adults burn the same number of calories to walk a mile as Westerners
do. It could be that people with high activity levels change their behavior in subtle ways that save energy, like
sitting rather than standing or sleeping more soundly. But our analysis of the METS data suggests that although
these behavioral changes might contribute, they are not sufficient to account for the constancy seen in daily energy

Another intriguing possibility is that the body makes room for the cost of additional activity by reducing the
calories spent on the many unseen tasks that take up most of our daily energy budget: the housekeeping work that
our cells and organs do to keep us alive. Saving energy on these processes could make room in our daily energy
budget, allowing us to spend more on physical activity without increasing total calories spent per day. For example,
exercise often reduces inflammatory activity that the immune system mounts as well as levels of reproductive
hormones such as estrogen. In lab animals, increased daily exercise has no effect on daily energy expenditure but
instead results in fewer ovulatory cycles and slower tissue repair. And extremes may lead some animals to eat their
own nursing infants. Humans and other creatures seem to have several evolved strategies for keeping daily energy
expenditure constrained.

All of this evidence points toward obesity being a disease of gluttony rather than sloth. People gain weight when
the calories they eat exceed the calories they expend. If daily energy expenditure has not changed over the course
of human history, the primary culprit in the modern obesity pandemic must be the calories consumed. This should
not be news. The old adage in public health is that “you can’t outrun a bad diet,” and experts know from personal

experience and lots of data that just hitting the gym to lose weight is frustratingly ineffective. But the new science
helps to explain why exercise is such a poor tool for weight loss. It is not that we are not trying hard enough. Our
bodies have been plotting against us from the start.

You still have to exercise. This article is not a note from your mom excusing you from gym class. Exercise has
tons of well-documented benefits, from increased heart and immune system health to improved brain function and
healthier aging. In fact, I suspect that metabolic adaptation to activity is one of the reasons exercise keeps us
healthy, diverting energy away from activities, such as inflammation, that have negative consequences if they go
on too long. For example, chronic inflammation has been linked to cardiovascular disease and autoimmune

The foods we eat certainly affect our health, and exercise paired with dietary changes can help keep off
unwanted pounds once a healthy weight has been reached, but evidence indicates that it is best to think of diet and
exercise as different tools with different strengths. Exercise to stay healthy and vital; focus on diet to look after
your weight.
Energy Budgets and Evolution

Even as the recent science in metabolic adaptation helps to clarify the relation between exercise and obesity, a
constrained, adaptive metabolism leaves researchers with larger, existential questions. If daily energy expenditure
is virtually immobile, how could humans evolve to be so radically different from our ape relatives? Nothing in life
is free. Resources are limited, and investing more in one trait inevitably means investing less in another. It is no
coincidence that rabbits reproduce prodigiously but die young; all that energy plowed into offspring means less for
bodily maintenance and longevity. Tyrannosaurus rex can thank its big head of nasty teeth and powerful hind
limbs for its puny arms and hands. Even dinosaurs couldn’t have it all.

Humans flout this bedrock evolutionary principle of austerity. Our brains are so large that, as you sit reading this
article, the oxygen from every fourth breath you take is needed just to feed your brain. Yet humans have bigger
babies, reproduce more often, live longer and are more physically active than any of our ape relatives. Hadza
camps are full of cheerfully chaotic children and hale, hearty men and women in their 60s and 70s. Our energetic
extravagance presents an evolutionary puzzle. Humans are so genetically and biologically similar to other apes that
researchers have long assumed that our metabolisms are similar, too. But if energy expenditures are as constrained
as our Hadza study and others suggest, how could an inflexible, apelike metabolism process all the calories needed
to support our costly human traits?

In the wake of our broad, comparative primate energetics study, my colleagues and I began to wonder whether
humans’ adaptive suite of energetically costly traits was fueled by a wholesale evolutionary change in metabolic
physiology. We had found in that study that primates burn only half as many calories a day as other mammals do.
The reduced metabolic rates of primates correspond with their slow rates of growth and reproduction. Perhaps,
conversely, the faster reproduction and other expensive traits of humans were linked to the evolution of an
increased metabolic rate. All that was needed to test this idea was getting a bunch of frenetic chimpanzees, wily
bonobos, phlegmatic orangutans and skittish silverback gorillas to carefully drink doses of doubly labeled water
without spilling and to provide a few urine samples. In a scientific tour de force, my colleagues Steve Ross and
Mary Brown, both at Lincoln Park Zoo in Chicago, worked with caretakers and veterinarians from more than a
dozen zoos across the U.S. to pull that off. It took a couple of years, but they accumulated enough data on great ape
energy expenditure to provide a solid comparison with humans.

Sure enough, humans burn more calories each day than any of our great ape relatives. Even after accounting for
effects of body size, activity level and other factors, humans consume and expend about 400 more calories a day
than chimpanzees and bonobos do; differences with gorillas and orangutans are larger still. Those extra calories
represent the extra work our bodies do to support larger brains, produce more babies and maintain our bodies so we
live longer. It is not simply that we eat more than other apes (although we do that, too); as we know all too well,
piling extra calories into a body that is not equipped to use them only results in obesity. Our bodies, right down to
the cellular level, have evolved to burn energy faster and get more done than our ape relatives. Human evolution
was not entirely without trade-offs: our digestive tract is smaller and less costly than other apes, which need a
large, energetically expensive gut to digest their fibrous, plant-based diets. But the critical changes that make us

human were fueled by an evolutionary shift in our metabolic engine.

Shared Fortunes

At some point in the late afternoon, our path bent toward camp, Mwasad looking ahead instead of searching the
ground. We were heading home sans giraffe. Here was the fundamental danger in the high-energy human strategy:
coming home empty-handed was both more likely and more consequential. Many of the energy-rich foods we need
to fuel our faster metabolisms are inherently difficult to obtain in the wild, increasing the energy cost of finding
food and heightening the risk of starvation for the men and women out foraging and their kids back at camp.
Happily for Mwasad, humans have evolved a few tricks to keep starvation at bay. We are the only species that
has learned to cook, which increases the caloric value of many foods and makes them more efficient to digest. Our
mastery of fire converts otherwise inedible root vegetables—from Trader Joe’s yams to wild Hadza tubers—into
veritable starch bombs. We have also evolved to be fat. We know this all too well from the obesity crisis in the
West, but even Hadza adults, lean by any human standard, carry twice as much fat as chimpanzees idling away in
zoos. Problematic though it may be in our modern era, our propensity to store fat most likely coevolved with our
faster metabolism as a critical energy buffer to survive lean times.

As the sun sat heavy and orange just above the trees, we melted back into camp, Dave and I toward our tents,
Mwasad and Neje to their families’ huts, each one of us glad to be home. Despite the lost giraffe, no one went
hungry that evening. Instead, with little fanfare or conscious effort, the camp deployed our species’ most ingenious
and powerful weapon against starvation: sharing. Sharing food is so fundamental to the human experience, the
common thread of every barbecue, birthday, bar mitzvah, that we take it for granted, but it is a unique and essential
part of our evolutionary inheritance. Other apes do not share.

Beyond our nutritional requirements and fixation with fat, perhaps the most profound impact of our increased
energy expenditure is this human imperative to work together. Evolving a faster metabolism bound our fortunes to
one another, requiring that we cooperate or die. As I sat with Dave and Brian, recounting the day’s adventures over
tinned sardines and potato chips, I realized I would not have had it any other way. No giraffe, no problem

Credit: Graphic by Jen Christiansen Sources: “Hunter-Gatherer Energetics and Human Obesity,” by Herman Pontzer et al., In Plos One, Vol. 7, No. 7, Article No. E40503; July 25, 2012; “Metabolic Acceleration and the
Evolution of Human Brain Size and Life History,” by Herman Pontzer et al., In Nature, Vol. 533; May 19, 2016.

--Originally published: Scientific American 316(2); 26-31 (February 2017).

The Messy Truth about Weight Loss
by Susan B. Roberts and Sai Krupa Das

The global obesity epidemic is one of the greatest health challenges facing humanity. Some 600 million, or 13
percent, of the world’s adults were obese in 2014—a figure that had more than doubled around the globe since
1980. At present, 37 percent of American adults are obese, and an additional 34 percent are overweight. If current
trends continue, health experts predict that half of all Americans will be obese by 2030.

If fad diets, reality television programs and willpower could make a dent in the problem, we would have seen a
change by now. Obesity (characterized by excess body fat and measured as 120 percent or more of ideal weight) is
much too complex to be solved with quick fixes, however. Figuring out why we eat what we eat, how the body
controls weight and how best to get people to change unhealthy habits is not easy. Our laboratory has spent the past
two decades trying to develop, with all the rigor that science allows, more effective methods for treating obesity
and maintaining a healthy weight.

Much of our work has challenged common dogmas and opened doors for new approaches. We have shown, for
example, that exercise is not the most important thing to focus on when you want to lose weight—although it has
numerous other health benefits, including maintaining a healthy weight. As many experts have suspected and as we
and others have now proved, what you eat and how much you eat play a substantially greater role in determining
whether you shed kilograms. But our research has gone much deeper, showing that different people lose weight
more effectively with different foods. This realization allows us to create personalized weight-loss plans for
individuals that work better than any one-size-fits-all advice.

We believe this new understanding could improve the health of millions of people around the world. Obesity
increases the risk of all the major noncommunicable diseases, including type 2 diabetes, heart disease, stroke and
several types of cancers— enough to decrease a person’s potential life span by as much as 14 years. Research
shows that excessive weight also interferes with our body’s ability to fight off infections, sleep deeply and age
well, among other problems. It is long past time for us to understand how to combat this epidemic.

Credit: Source CDC


Losing weight can be reduced to a simple mathematical formula: burn more calories than you consume. For
decades health experts figured that it did not matter too much how you created that deficit: as long as you got the
right nutrients, you could safely lose weight with any combination of increased exercise and reduced consumption
of food. But this assumption does not take into account the complexities of human physiology and psychology and
so quickly falls apart when tested against real-world experience . As it happens, sorting out the details and putting
weight management on a more scientific footing have taken much longer and have required a wider range of
expertise than anyone had expected.

Our first step, beginning in the 1990s, was to determine a base requirement: How much energy does it take to
fuel the average human body? This straightforward question is not easy to answer. People get their energy from
food, of course. But for individuals to use that energy, the food must be broken down or metabolized to become the
equivalent of gasoline for a car. The oxygen we breathe helps to burn that fuel, and whatever is not used right away
is stored in the liver as glycogen (a form of carbohydrate) or fat. When no more space is available in the liver, the
excess is stored elsewhere in fat cells. In addition, metabolism creates carbon dioxide, which we exhale, as well as
other waste products that are excreted as urine and feces. The process runs at different levels of efficiency in
different individuals and under different circumstances in the same individual.

For a long time the best way to measure people’s energy expenditure was to have them live for two weeks in a
specialized lab, such as ours, where researchers could measure everything subjects eat and track their weight.
Another way was to put volunteers in a sealed room (called a calorimeter) and measure the oxygen they breathe
and the carbon dioxide they exhale. From these measurements we could assess the body’s basic energy
requirements. Neither method is terribly convenient, and neither does a good job of replicating the conditions of
everyday life.

A much easier approach uses so-called doubly labeled water, which contains tiny amounts of deuterium (2H) and

oxygen 18 (18O), both harmless, nonradioactive isotopes. For one to two weeks after a person drinks doubly
labeled water, the body excretes the deuterium and some of the oxygen 18 in urine. (The rest of the oxygen 18 is
exhaled as carbon dioxide.) Investigators take urine samples and compare how quickly these two isotopes
disappear from the body during that time. With these data, they can calculate the number of calories an individual
burns without interrupting his or her daily routine.

The method was developed in the 1950s, but for decades doubly labeled water was too expensive to use in
people. By the 1980s prices had dropped, and the technique had become more efficient, although there were times
when our lab had to spend as much as $2,000 to perform a single measurement. As a result, it took more than 20
years to accumulate enough data to figure out how much energy the body needs to avoid weight gain or loss.

These experiments—conducted by our group and others—helped us determine that humans do not need a lot of
calories to stay healthy and active. And any excess consumption quickly results in weight gain. In this respect, we
are much like other primates, including chimpanzees and orangutans. An adult male of healthy weight and typical
height living in the U.S. today requires about 2,500 calories per day to maintain his weight, whereas the average
nonobese adult female requires around 2,000 calories. (Men tend to use more calories because, on average, they
have larger bodies and greater muscle mass.)
In contrast, studies show that species as diverse as red deer (Cervus elapus, average weight 100 kilograms for
the six-year-old females in one experiment) and gray seals (Halichoerus grypus, average weight 120 kilograms for
three adult females) require two to three times more calories, kilogram per kilogram, than primates to maintain
their size.

It is tempting to assume that Americans have low calorie requirements because they lead sedentary lives, but
researchers have documented similar calorie needs even in indigenous populations leading very active lives.
Herman Pontzer of Hunter College and his colleagues measured the calorie requirements of the Hadza people in
northern Tanzania, a group of hunter-gatherers, and found that the men needed 2,649 calories on average per day.
The women, who—like the men—tend to be smaller than counterparts in other regions, needed just 1,877. Another
study of the indigenous Yakut people of Siberia found requirements of 3,103 calories for men and 2,299 for
women. And members of the Aymara living in the Andean altiplano were found to require 2,653 calories for men
and 2,342 calories for women.

Although our calorie requirements have not changed, government data show that, on average, Americans
consume 500 more calories (the equivalent of a grilled chicken sandwich or two beef tacos at a fast-food restaurant
) each day than they did in the 1970s. An excess of as little as 50 to 100 calories a day—the equivalent of one or
two small cookies—can lead to a gain of one to three kilograms a year. That easily becomes 10 to 30 kilograms
after a decade. Is it any wonder, then, that so many of us have become overweight or obese?

Complicated Calories

The formula for maintaining a stable weight—consume no more calories than the body needs for warmth, basic
functioning and physical activity—is just another way of saying that the first law of thermodynamics still holds for
biological systems: the total amount of energy taken into a closed system (in this case, the body) must equal the
total amount expended or stored. But there is nothing in that law that requires the body to use all sources of food
with the same efficiency. Which brings us to the issue of whether all calories contribute equally to weight gain.
Research in this area is evolving, and understanding why it has taken so long to get definitive answers requires a
trip back in history to the late 1890s and the tiny community of Storrs, Conn. There a chemist by the name of
Wilbur O. Atwater built the first research station in the U.S. designed to study the production and consumption of
food. In fact, Atwater was the first to prove that the first law of thermodynamics holds for humans as well as
animals. (Some scientists of his day thought people might be an exception to the rule.)

The experimental design of metabolic labs has changed remarkably little since Atwater’s day. To determine how
much energy the body can derive from the three major components of food—proteins, fats and carbohydrates—he
asked a few male volunteers to live, one at a time, inside a calorimeter for several days. Meanwhile Atwater and
his colleagues measured everything each human guinea pig ate, as well as what became of that food, from the

carbon dioxide the volunteer exhaled to the amounts of nitrogen, carbon and other components in his urine and
feces. Eventually the researchers determined that the body can extract about four calories of energy per gram from
proteins and carbohydrates and nine calories per gram from fat. (These numbers are now known as Atwater

Food does not come to us as pure protein, carbohydrate or fat, of course. Salmon consists of protein and fat.
Apples contain carbohydrates and fiber. Milk contains fat, protein, carbohydrates and a lot of water. It turns out
that a food’s physical properties and composition play a greater role in how completely the body can digest and
absorb calories than investigators had anticipated.

In 2012, for example, David Baer of the U.S. Department of Agriculture’s Beltsville Human Nutrition Research
Center in Maryland proved that the body is unable to extract all the calories that are indicated on a nutritional label
from some nuts, depending on how they are processed. Raw whole almonds, for example, are harder to digest than
Atwater would have predicted, so we get about a third fewer calories from them, whereas we can metabolize all the
calories found in almond butter.
Whole grains, oats and high-fiber cereals are also digested less efficiently than we used to think. A recent study
by our team looked at what happened when volunteers consumed a whole-grain diet that included 30 grams of
dietary fiber versus more typical American fare that contained half as much fiber. We detected an increase in the
number of calories lost to the feces, as well as a bump in metabolism. Together these changes amounted to a net
benefit of nearly 100 calories a day—which can have a substantial effect on weight over a period of years.

And so we and others have proved that not all calories are equal—at least for nuts and high-fiber cereals. As
scientists learn more about how efficiently different foods are digested and how they affect the body’s metabolic
rate, we will likely see some other examples of such disparities that are just large enough to influence how easy—
or hard—individuals find managing their weight.

Energy Expenditure

So much for what we put in our mouth. What our body does with the food we eat brings us to the other side of
the energy balance equation—energy expenditure. Researchers are discovering a surprising deal of variability here
as well.

One of the most common pieces of advice that people get when they are trying to lose weight is that they should
exercise more. And physical activity certainly helps to keep your heart, brain, bones and other body parts in good
working order. But detailed measurements conducted in our lab and others show that physical activity is
responsible for only about one third of total energy expenditure (assuming a stable body weight). The body’s basal
metabolism—that is, the energy it needs to maintain itself while at rest—makes up the other two thirds.
Intriguingly, the areas of the body with the greatest energy requirement are the brain and certain internal organs,
such as the heart and kidneys—not the skeletal muscle, although strength training can boost basal metabolism

In addition, as anyone who has ever reached middle age understands all too well, metabolism changes over time.
Older people need fewer calories to keep their body running than they did in their youth. Metabolic rate also differs
among individuals. One study published in 1986 measured the metabolic rates of 130 people from 54 families.
After accounting for differences in age, gender and body composition, investigators reported variability among
families of around 500 calories a day. The inescapable conclusion: when it comes to metabolic rate—and your
ability to lose or maintain your weight—parentage makes a difference.

But let us suppose that you have started to lose some weight. Naturally, your metabolic rate and calorie
requirements must fall as your body becomes smaller, meaning that weight loss will slow down. That is just a
matter of physics: the first law of thermodynamics still applies. But the human body is also subject to the pressures
of evolution, which would have favored those who could hold on to their energy stores by becoming even more
fuel-efficient. And indeed, studies show that metabolic rate drops somewhat more than expected during active
weight loss. Once a person’s weight has stabilized at a new, lower level, exercise can help in weight management
by compensating for the reduced energy requirement of a smaller body.

Hungry Brains

Variations in Atwater factors and metabolic rates are not the end of the story. A growing body of research has
demonstrated that our brain plays a central role, coordinating incoming signals from a wide range of physiological
sensors in the body while alerting us to the presence of food. The brain then creates sensations of hunger and
temptation to make sure that we eat.

In other words, the role of hunger has long been to keep us alive. Thus, there is no point in fighting it directly.
Instead one of the keys to successful weight management is to prevent hunger and temptation from happening in
the first place.
Single-meal feeding tests by several labs, including our own, show that meals higher in protein or fiber or those
that do not cause a sudden spike in blood sugar (glucose) levels are generally more satisfying and better at
suppressing hunger. (Carbohydrates are the most common source of glucose in the blood, but proteins can generate
it as well.) A summary one of us (Roberts) published in 2000 indicated that calorie consumption in the hours
following a breakfast with a so-called high glycemic index (think highly processed breakfast cereals) was 29
percent greater than after a morning meal with a low glycemic index (steel-cut oatmeal or scrambled eggs).

In fact, our team recently obtained the first preliminary data showing that it is possible to reduce hunger during
weight loss by choosing the right foods. Before assigning 133 volunteers to one of two groups, we asked them to
answer a detailed questionnaire about how often, when and how intensely they were hungry. Then we randomly
assigned subjects to either a weight-loss program that emphasized foods high in protein and fiber and low in
glycemic index (fish, beans, apples, vegetables, grilled chicken and wheat berries, for example) or to a “waiting
list,” which served as the control group.

Remarkably, over the course of six months members of the experimental group reported hunger levels that
decreased to below the values measured before the program began. We noticed a difference on the scales as well.
By the end of the study, they had also lost an average of eight kilograms, whereas the control group had gained 0.9

Just as interesting, the intervention group experienced fewer food cravings as well, which suggests that what
their brains perceived as pleasurable had changed. We then scanned the brains of 15 volunteers as they viewed
pictures of a wide range of foods. The results showed that the reward center of the brain became more active over
time in the intervention group in response to pictures of grilled chicken, whole-wheat sandwiches and fiber cereal.
Meanwhile that group’s brains became less responsive to images of french fries, fried chicken, chocolate candies
and other fattening foods.

The Energy Equation

The laws of thermodynamics apply to biological organisms just as much as anything else in the universe. The number
of calories that we absorb from food has to equal the number of calories our body either expends or stores. But the
simplest methods for balancing this equation are not necessarily the most true to life. Individuals do not, for example,
process all foods equally effectively. And different people require different amounts of energy just to keep their body
humming. The graphic illustrates a few of the known complexities.

Credit: Graphic by Brown Bird Design (food illustrations) and Amanda Montañez.
Sources: U.S. Department of Agriculture Food Composition Databases (food data); “High-Protein Weight-Loss Diets: Are They Safe and Do They Work? A Review of the Experimental and Epidemiologic Data,” by Julie
Eisenstein et al., In Nutrition Reviews, Vol. 60, No. 7; July 2002 (thermic effect data ); Human Energy Requirements: Report of a Joint FAO/WHO/UNU Expert Consultation. World Health Organization, Food and Agriculture
Organization of the United Nations and United Nations University. FAO 2001 (basal metabolism data ); “High Glycemic Index Foods, Overeating, and Obesity,” by David S. Ludwig et al., In Pediatrics, Vol. 103, No. 3; March
1999 (glycemic index data).

Personalized Diets

Differences in the hunger-reducing properties of foods, the efficiency with which they are absorbed and the real,
though limited, ability of our metabolism to adapt to changes in energy intake make weight management a complex
system. We keep finding special circumstances that affect various people differently. For example, it has been well
established that the majority of individuals who are obese secrete proportionately higher levels of insulin, the
hormone that helps the body to metabolize glucose. This so-called insulin resistance leads to a host of other
metabolic problems, such as increased risk of heart attack or developing type 2 diabetes. When we placed such
people on a six-month weight-loss program featuring more protein and fiber, fewer carbohydrates and a low
glycemic index, we found that they lost more weight than they could on a high-carbohydrate diet with a high
glycemic index. People with low insulin levels, in contrast, did equally well on diets that were higher or lower in
the ratio of proteins and carbohydrates, as well as in glycemic index.

Today we regularly help our study volunteers lose weight and keep it off. Despite the fact that our 133-volunteer
investigation, described earlier, was six months long and required participants to attend weekly meetings and reply
to e-mails during most of that time, only 11 percent dropped out. Some even cried at the re search team’s final visit
because they did not want to say goodbye. Not only had they lost weight, but they had been so much more
successful than they expected that they felt transformed psychologically as well as physically. In the words of one
participant, “the science worked.”
--Originally published: Scientific American 316(6); 36-41 (June 2017).

The “True” Human Diet
by Peter Ungar

People have been debating the natural human diet for thousands of years, often framed as a question of the
morality of eating other animals. The lion has no choice, but we do. Take the ancient Greek philosopher
Pythagoras, for example: “Oh, how wrong it is for flesh to be made from flesh!” The argument hasn’t changed
much for ethical vegetarians in 2,500 years, but we also have Sarah Palin, who wrote in Going Rogue: An
American Life, “If God had not intended for us to eat animals, how come He made them out of meat?” Have a look
at Genesis 9:3.

While humans don’t have the teeth or claws of a mammal evolved to kill and eat other animals, that doesn’t
mean we aren’t “supposed” to eat meat, though. Our early Homo ancestors invented weapons and cutting tools in
lieu of sharp carnivore-like teeth. There’s no explanation other than meat eating for the fossil animal bones riddled
with stone tool cut marks at fossil sites. It also explains our simple guts, which look little like those evolved to
process large quantities of fibrous plant foods.
But gluten isn’t unnatural either. Despite the pervasive call to cut carbs, there’s plenty of evidence that cereal
grains were staples, at least for some, long before domestication. People at Ohalo II on the shore of the Sea of
Galilee ate wheat and barley during the peak of the last ice age, more than 10,000 years before these grains were
domesticated. Paleobotanists have even found starch granules trapped in the tartar on 40,000-year-old Neandertal
teeth with the distinctive shapes of barley and other grains, and the telltale damage that comes from cooking.
There’s nothing new about cereal consumption.

This leads us to the Paleolithic Diet. As a paleoanthropologist I’m often asked for my thoughts about it. I’m not
really a fan—I like pizza and French fries and ice cream too much. Nevertheless, diet gurus have built a strong case
for discordance between what we eat today and what our ancestors evolved to eat. The idea is that our diets have
changed too quickly for our genes to keep up; and the result is said to be “metabolic syndrome,” a cluster of
conditions including elevated blood pressure, high blood-sugar level, obesity, and abnormal cholesterol levels. It’s
a compelling argument. Think about what might happen if you put diesel in an automobile built for regular
gasoline. The wrong fuel can wreak havoc on the system, whether you’re filling a car or stuffing your face.

It makes sense, and it’s no surprise that Paleolithic diets remain hugely popular. There are many variants on the
general theme, but foods rich in protein and omega-3 fatty acids show up again and again. Grass-fed cow meat and
fish are good, and carbohydrates should come from nonstarchy fresh fruits and vegetables. On the other hand,
cereal grains, legumes, dairy, potatoes, and highly refined and processed foods are out. The idea is to eat like our
Stone Age ancestors—you know, spinach salads with avocado, walnuts, diced turkey, and the like.

I am not a dietician, and cannot speak with authority about the nutritional costs and benefits of Paleolithic diets,
but I can comment on their evolutionary underpinnings. From the standpoint of paleoecology, the Paleolithic diet is
a myth. Food choice is as much about what’s available to be eaten as it is about what a species evolved to eat. And
just as fruits ripen, leaves flush, and flowers bloom predictably at different times of the year, foods available to our
ancestors varied over deep time as the world changed around them from warm and wet to cool and dry and back
again. Those changes are what drove our evolution.

Even if we could reconstruct the precise nutrient composition of foods eaten by a particular hominin species in
the past (and we can’t), the information would be meaningless for planning a menu based on our ancestral diet.

Because our world was ever changing, so too was the diet of our ancestors. Focusing on a single point in our
evolution would be futile. We’re a work in progress. Hominins were spread over space too, and those living in the
forest by the river surely had a different diet from their cousins on the lakeshore or the open savanna.

What was the ancestral human diet? The question itself makes no sense. Consider some of the recent hunter-
gatherers who have inspired Paleolithic diet enthusiasts. The Tikiġaġmiut of the north Alaskan coast lived almost
entirely on the protein and fat of marine mammals and fish, while the Gwi San in Botswana’s Central Kalahari
took something like 70 percent of their calories from carbohydrate-rich, sugary melons and starchy roots.
Traditional human foragers managed to earn a living from the larger community of life that surrounded them in a
remarkable variety of habitats, from near-polar latitudes to the tropics. Few other mammalian species can make
that claim, and there is little doubt that dietary versatility has been key to the success we’ve had.

--Originally published: Scientific American Online, April 2017.

Mind over Meal: Weight-Loss Surgery and the Gut-Brain Connection
by Bret Stetka

For Teresa, the first plate of scrambled eggs was a transcendent experience. The 41-year-old Stanford University
Medical Center nurse coordinator had completely lost her appetite in the days after her surgery. She ate, but only
liquids and only at her surgeon’s request. Yet when her interest in eating returned, it was as though something
about her relationship with food had fundamentally changed.

The eggs, Teresa’s first solid meal in four weeks, were a revelation: simple, soft and buttery. To her surprise,
they constituted a completely satisfying meal. Gone was the desire for sweets and excessively salted savories. Her
once beloved french fries and rich desserts no longer enticed her. Her desire to eat was back, but for the first time
in her life eating “right” came easy.
Teresa had undergone a sleeve gastrectomy, one of a variety of procedures—known as bariatric surgeries—that
manipulate the stomach and intestines to promote weight loss. Yet more than shedding pounds, which she did, it
was the complete change in cravings that Teresa considers the most surprising result of her 2012 operation.

She had struggled with her weight since childhood. Years of hormone therapy while trying to get pregnant did
not help, nor did pregnancy itself. “Before I knew it, I was 270 pounds,” Teresa recalls. “And I just couldn’t get the
extra weight off despite trying everything: every diet, lots of exercise.” The surplus pounds also made it hard to
manage a toddler. “I couldn’t keep up with my son,” she says.

A sleeve gastrectomy can shrink the stomach from the size of a football to that of a banana, roughly 15 percent
of its original size. One year later—after months of eating healthier and eating less—Teresa was down to 150
pounds. “That was actually even low for me,” she says, “but the surgery really changed how I ate.”

Since the 1960s, when these techniques were introduced, doctors have considered bariatric surgery primarily a
mechanical fix. A smaller stomach, the reasoning went, simply cannot hold and process as much food. Patients get
full faster, eat less and therefore lose weight.

This idea is in part true. But now scientists know that it is not nearly that simple. Teresa’s weight loss was in all
likelihood caused by the drastic change in how her gut speaks to her brain, and vice versa. The procedure had
indirectly spurred new neural connections, changing how she thought about and craved food.
Recent science has revealed that appetite, metabolism and weight are regulated through a complex dialogue
between bowel and brain—one in which mechanical influences, hormones, bile acids and even the microbes living
in our gut all interact with labyrinthine neurocircuitry. Bariatric surgery, scientists are discovering, engages and
may change all these systems. In the process, it is helping researchers map how this complicated interplay
manipulates our eating behaviors, cravings and frenzied search for calories during starvation. This work could also
reveal new targets—including microbes and possibly the brain itself—that render the risky surgical procedure
obsolete altogether.

Brain Meets Bowel

We have all felt the physical effects of the gut-brain communion: the gastric butterflies that come with love, the
rumbles that arise before delivering a speech. These manifestations result from the brain signaling to the

gastrointestinal tract, both through hormones and neuronal signals.

Conversely, the gut can send signals back to the brain, too. In fact, coursing through our abdomen is the enteric
nervous system, colloquially known as the second brain. This neural network helps to control food digestion and
propulsion through the 30 feet of our gastrointestinal tract. It also communicates directly with the brain through the
vagus nerve, which connects the brain with many of our major organs.

Two primary gut-brain pathways regulate appetite. Both systems involve a small, central brain region called the
hypothalamus, a hotbed of hormone production that helps to monitor numerous bodily processes.
The first system comes into play during fasting. The stomach secretes the hormone ghrelin, which stimulates a
region within the hypothalamus called the arcuate nucleus. This structure then releases neuropeptide Y, a
neurotransmitter that, in turn, revs up appetite centers in the cerebral cortex, the outer folds of the brain, driving us
to seek out food. In anticipation of mealtime, our brain sends a signal to the stomach via the vagus nerve, readying
it for digestion. “This can occur simply at the sight, smell or thought of food,” says Mayo Clinic gastroenterologist
and obesity expert Andres Acosta Cardenas. “Our brain is preparing our body for a meal.”

The second gut-brain pathway suppresses our appetite. As we eat, several other hormones, including leptin and
insulin, are secreted from fat tissue, the pancreas and the gastrointestinal tract. Separately, these hormones play
many roles in digestion and metabolism. Acting together, they signal to another area of the hypothalamus that we
are getting full. Our brain tells us to stop eating.

The appetite and satiety loop constantly hums along. Yet hunger pathways also interact with brain regions such
as the amygdala, involved in emotion, and the hippocampus, the brain’s memory center. Hence, our “gut feelings”
and “comfort foods” are driven more by moods than mealtimes and nostalgic recollections of Grandma’s rhubarb
pie. As a result of higher thinking processes, food now has context. Food is culture. As playwright George Bernard
Shaw put it, “There is no sincerer love than the love of food.”

Then there is the hedonistic thrill of sitting down to a meal. Eating also lights up our reward circuitry, pushing us
to eat for pleasure independent of energy needs. It is this arm of the gut-brain axis that many scientists feel
contributes to obesity.

Neuroimaging work confirms that, much like sex, drugs, gambling and other vices, food can cause a surge of
dopamine release in the brain’s reward circuitry. This neurotransmitter’s activity serves as a powerful motivator,
one that can reinforce dining for its own sake rather than subsistence. Researchers have found that for rats,
sweetness surpasses even cocaine in its desirability. In humans, psychiatrist Nora Volkow, director of the National
Institute on Drug Abuse, has confirmed what chocolate lovers everywhere already know: food’s effects on the
reward system can override fullness and motivate us to keep eating. Such findings hint at a neurobiological overlap
between addiction and overeating, although whether eating can be an outright addiction remains a controversial
The Surgical Solution

Thanks to the flow of messenger hormones and neurotransmitters, our mind and stomach are in constant
communication. Disrupting this conversation, as bariatric procedures must do, will therefore have consequences.

Research has shown that in the days and weeks after bariatric surgery, sugary, fatty and salty foods become less
palatable (as Teresa discovered). One study, published in 2010 by Louisiana State University neurobiologist Hans-
Rudolf Berthoud, found that rats lost their preference for a high-fat diet following gastric bypass surgery. In the
1990s multiple research teams had reported that after such surgery, patients often lose the desire to consume sweet
and salty foods. More recently, a 2012 study by a team at Brown University found that adult patients had
significantly reduced cravings for sweets and fast food following bariatric surgery. Similar findings in adolescent
surgery patients also appeared in a 2015 study.

The alteration in cravings and taste may be caused by changes in the release and reception of neurotransmitters
throughout the gut-brain system. In 2016 Berthoud and his colleagues found that in the short term—around 10 days

postprocedure—bariatric surgery in mice caused additional meal-induced neural activity in brain regions known to
communicate with the gut compared with brain activity before the surgery. Specifically, the boost in activity was
seen in a connection leading from stomach-sensing neurons in the brain stem to the lateral parabrachial nucleus,
part of the brain’s reward system, as well as the amygdala.

An expert in this area is biochemist Richard Palmiter of the University of Washington. In a 2013 study published
in Nature, Palmiter’s group used complex genetic and cell-stimulation techniques—including optogenetics, a
means of controlling living tissue using light—to activate or silence specific neurons in the brain stem parabrachial
nucleus pathway in mice. He found that engaging this circuit strongly reduced food intake. But deactivating it left
the brain insensitive to the cocktail of hormones that typically signaled satiety—such that mice would keep eating.

Palmiter’s work suggests that engagement of the brain stem parabrachial pathway helps us curb our appetite.
Because it is this same pathway that becomes unusually active postsurgery, it is probable that the hyperactivation
Berthoud discovered is part of the gut-brain’s effort to assess satisfaction postsurgery. As he puts it, “the brain
must relearn how to be satisfied with smaller portions.”
In other words, bariatric surgery is certainly a mechanical change: with less space, the body needs to adjust. Still,
there is clearly more to the story. After the procedure, more undigested food may reach the intestine, and, Berthoud
speculates, it would then trigger a hormonal response that alerts the brain to reduce food intake. In the process, it
would alter the brain’s activity in response to eating. If he is correct, the surgery’s success—at least in the short
term—may have as much to do with its effects on the gut-brain axis as it does on the size of a person’s stomach.

The Microbial Mind

There is another player in the complex communications of mind and gut that might explain bariatric surgery’s
effects. Experts have implicated the microbiota—the trillions of single-celled organisms bustling about our
digestive system—in countless disorders, including many that affect the brain. Our co-denizens and their genome,
the “microbiome,” are thought to contribute to autism, multiple sclerosis, depression and schizophrenia by
communicating with the brain either indirectly via hormones and the immune system or directly through the vagus

Research by gastroenterologist Lee Kaplan, director of the Massachusetts General Hospital Weight Center,
suggests that the microbiota may play a role in obesity. In a study published in 2013 in Science Translational
Medicine, Kaplan and his colleagues transferred the gut microbiota from mice that had undergone gastric bypass
surgery to those that had not. Whereas the surgery group lost nearly 30 percent of their body weight, the
transplanted mice lost a still significant 5 percent of their body weight. (Meanwhile a control group that did not
have surgery experienced no significant weight change.) The fact that rodents could lose weight without surgery,
simply by receiving microbes from their postoperative fellows, suggests that these microbial populations may be at
least partly responsible for the effectiveness of bariatric procedures.

A similar study, published in 2015 by biologist Fredrik Bäckhed of the University of Gothenburg in Sweden,
found that two types of bariatric surgery—the Roux-en-Y gastric bypass and vertical banded gastroplasty—
resulted in enduring changes in the human gut microbiota. These changes could be explained by multiple factors,
including altered dietary patterns after surgery; acidity levels in the gastrointestinal tract; and the fact that the
bypass procedure causes undigested food and bile (the swamp-green digestive fluid secreted by the liver) to enter
the gut farther down the intestines.
As part of the same research, Bäckhed and his colleagues fed mice microbiota samples from obese human
patients who either had or had not undergone surgery. All the rodents gained varying degrees of body fat, but mice
colonized with postsurgical microbiota samples gained 43 percent less.

How might changes in our gut’s flora alter their interactions with the gut-brain axis and affect weight? Although
the answer is still unclear, there are a few promising leads.

Specific gut microbial populations can trigger hormonal and neuronal signaling to the brain such that they
influence the development of neural circuits involved in motor control and anxiety. Bäckhed suspects gut flora

after bariatric surgery could have a comparable effect on brain regions associated with cravings and appetite.

The neurotransmitter serotonin could play a special role as well. About 90 percent of our body’s serotonin is
produced in the gut, and in 2015 researchers at the California Institute of Technology reported that at least some of
that production relies on microbes. Change the microbes; change the serotonin production. And that could make
quite a difference because, as numerous studies have confirmed, stimulating the brain’s serotonin receptors can
significantly reduce weight gain in rodents and humans.

Treating the Gut-Brain Axis

It is a welcome turn of fate that bariatric surgery is illuminating new directions in treating obesity—which
affects more than 600 million people worldwide. Some of these avenues could render surgery obsolete or at least
reserved for the most extreme cases. Thus, at the forefront of battling excess weight may be hijacking the gut-brain

In 2015, for example, the U.S. Food and Drug Administration approved a device that stimulates the vagus nerve
to quell food cravings. A surgeon implants the device, made up of an electrical pulse generator and electrodes, in
the abdomen so that it can deliver electric current to the vagus nerve. Although precisely how it works is unknown,
the study leading to its approval found that patients treated for one year with this tool lost 8.5 percent more of their
excess weight than those without the device.

That approach offers some patients a less invasive alternative to bariatric surgery, but for the moment, vagus
nerve stimulators are not as effective as many other obesity therapies. Meanwhile a number of intrepid
neurosurgeons are investigating the use of a technique called deep-brain stimulation. Approved for use in
Parkinson’s disease and obsessive-compulsive disorder, the procedure involves stimulating specific brain regions
using implanted electrodes. Although this research is in its infancy, numerous brain regions involved in appetite
control are being explored as possible targets.

The Mayo Clinic’s Acosta Cardenas believes that in the future the best approach to treating obesity will be
highly personalized. “Obesity is a disease of the gut-brain axis,” he says, “but I think we need to identify which
part of the axis is abnormal in each patient to personalize treatment. I’m trying to identify which patients have a
problem with the microbiome, or hormones, or emotional eating so we can maximize response to treatment.”

In 2015 Acosta Cardenas and his colleagues looked at numerous factors potentially related to obesity in more
than 500 normal-weight, overweight and obese patients. Among the factors were how quickly the study subjects
got full, how quickly their stomachs emptied, hormone levels in response to eating and psychological traits. Acosta
Cardenas’s findings support the idea that there are clear subclasses of obesity and that the cause and ideal treatment
of obesity is most likely unique to each patient. For example, 14 percent of the obese individuals in his study have
a behavioral or emotional component that would steer his treatment recommendation away from surgery and
medication and toward behavioral therapy. He can also foresee a future in which he might prescribe a probiotic or
antibiotic for obesity patients with an abnormal microbiota.

At the moment there is no telling with certainty which perturbations of the gut-brain axis caused Teresa’s weight
gain. But it is clear that she has benefited from surgery, maintaining her desired weight of 160 pounds for more
than four years to date. Her feet do not hurt anymore. She has more energy. She can keep up with her son. And
although she admits certain cravings have crept back during the years, they are not as intense as they once were
and are far more manageable.

“Before my surgery I had no self-control. I couldn’t hold back,” Teresa recalls. “Now if french fries show up at
the dinner table, I may have a few, but I don’t have to deprive myself. I just don’t have the drive to eat that way
anymore. I will inevitably take half of my meal home.”

--Originally published: Scientific American MIND 28(4); 27-34 (July/August 2017).

Behavioral Intervention

Don’t Diet!
by Charlotte N. Markey

My friend Ann (not her real name) recently tried the Paleo diet. She stopped eating dairy, grains, refined sugars
and processed foods. Six weeks in, Ann had lost 15 pounds. But in that time, she had skipped happy hours, girls’
nights out, office parties—really any occasion that might have put her in arm’s reach of temptation.

Ann missed her old life. She soon slid into her prediet habits and quickly gained back the pounds, plus a few
more—a familiar experience for her. Ann has lost weight on many diets, but she can never maintain the regimen
for long. After she quits, the scale, like a pendulum, always swings back up.
Her predicament is not unusual. At any given time, at least one in five American adults reports being on a diet,
but the majority don’t keep the weight off. A huge amount of scientific evidence tells us that dieting does not
promote lasting weight loss. In fact, many dieters end up gaining back more weight after they quit.

When I say “diet,” I am referring to eating regimens that require cutting portions, severely restricting calories, or
eliminating entire food groups: carbs, fats, sweets, whatever. Despite such deprivations, diets remain alluring
because they offer a clear and quick prescription dictating what you should and should not eat. These tactics are
meant to tame erratic eating behaviors and revise poor food choices. But the truth is that such strategies hardly ever
work because they are too extreme and thus almost impossible to maintain over the long term.

My advice as a psychologist and researcher who focuses on weight control: Do not diet. Do not cut out groups of
foods or count calories. Do not try to eat very little or deprive yourself. Such strategies backfire because of
psychological effects that every dieter is all too familiar with: intense cravings for foods you have eliminated,
bingeing on junk food after falling off the wagon, an intense preoccupation with food. A growing body of research
shows why these tendencies undermine most people’s diet efforts and confirms that the way around these pitfalls is
moderation. Making small changes to your eating patterns, ones you can build on slowly over time, is truly the best
pathway to lasting weight loss. Although you may have heard this message of moderation before, the evidence is
finally too overwhelming to ignore.

Effective weight management is particularly important when we consider that two thirds of Americans older
than 20 are overweight or obese. With the rise in obesity rates and related health problems, such as diabetes and
heart disease—both of which are leading causes of death in the U.S.—it has become even more critical for us all to
approach weight loss armed with a keen understanding of what really works and what doesn’t. Let’s start with
what doesn’t.

Why Typical Diets Fail

The “what the hell effect”: Studies have consistently revealed that dieting usually leads to weight gain, not
weight loss. In a 2013 review published online in Frontiers in Psychology, investigators reported that 15 of 20
studies showed that dieting predicted weight gain in adolescents and adults of normal weight.

One problem with diets is that once you give into temptation after restricting yourself, you are more likely to
binge. This tendency, which psychologists dub the “what the hell effect,” undermines attempts to lose weight. A
2010 study by psychologists at the University of Toronto demonstrated this effect in people who believed they had
broken their diet. In the study, 106 female students—some of whom were dieting and some of whom were not—all

received identical slices of pizza. Some of the students saw a person carrying another slice that was either bigger or
smaller than the one they got, and others did not see another slice. After they ate the pizza, the participants were
asked to taste-test a range of cookies. Women who weren’t dieting and dieters who thought they had eaten a
smaller than usual slice or who didn’t see a comparison slice ate a small amount of cookies. But dieters who
thought they had violated their diet by eating a bigger slice ate more cookies than everyone else.

The researchers suggest that these women believed they had already blown their diet—so what the hell, might as
well pig out on cookies. This study and many others like it confirm that violating or even thinking you have gone
off your diet is enough to abandon self-control.

Ironic processing: Some diets promise you’ll avoid feelings of deprivation by letting you eat as much as you
want of certain food groups while totally eliminating others. The trouble is that when you eliminate your favorite
foods—a requirement of most weight-loss regimens—you develop a deeper longing for them. Vow to avoid pasta,
and you will soon find yourself dreaming about spaghetti.
Food preoccupation is an inevitable result of dieting. Psychologists call this phenomenon “ironic processing”—
suppressing a thought makes it more salient. It became famous when the late social psychologist Daniel M.
Wegner did a series of experiments—the white bear studies—in which he asked subjects to avoid all thoughts of a
white bear. Guess what creature relentlessly prowled through their minds!

Many studies over the years have shown that people who try to eliminate food groups end up craving those
foods intensely. One published this year confirms that finding and adds to mounting evidence that not only do
people crave the forbidden food, they eat more of it when they get a chance. The study compared eating patterns in
23 normal-weight nondieters who restricted their intake of palatable foods, such as doughnuts and ice cream, and
23 similar people who merely recorded their snack intake. The researchers found that participants who restricted
themselves reported craving and eating more treats, whereas those who simply monitored their snacks did not. This
growing line of research suggests that for most, eliminating foods entirely will backfire badly.

In fact, treating yourself to indulgences may help you avoid the pitfalls of craving and overeating forbidden
foods. In a 2012 study, 144 obese men and women were put on a strict, low-calorie diet for 16 weeks. About half
ate a regular breakfast—300 calories—and the rest consumed a larger breakfast—600 calories—which included
something sweet, such as a doughnut or chocolate (and ate less at dinner to make up for it). In the second half of
the study, participants tried to maintain their meal plans on their own for 16 more weeks. The participants kept
food diaries and continued to receive counseling from a dietitian.

After the initial 16 weeks of close monitoring, the small breakfast group had lost a few more pounds than the
large breakfast group (33 versus 30 pounds). But in the self-maintenance 16-week period, the small breakfast group
regained 25 pounds, whereas the large breakfast group continued to shrink, dropping 15 additional pounds. Notably
the small breakfast group reported increased cravings for sweets, fats and fast foods at the end of the study,
whereas the large breakfast group reported reduced cravings in each category. Although eating dessert for breakfast
is not necessarily the fastest or healthiest route to weight loss, these findings demonstrate that it is possible to have
your cake and lose weight, too.

Mental fatigue: Although efforts to change your eating behaviors require attention and record keeping,
especially at the beginning, focusing too much energy on what you eat reduces your ability to do other, potentially
more important things. Studies that examine the mental energy available to dieters versus nondieters consistently
reveal that dieters have more difficulty learning new information, solving problems and exerting self-control.

Overthinking your food choices may also have deleterious consequences for your mental health. A 2010 study in
Appetite looked at the mental toll of eating chocolate among dieters and nondieters. The nondieters were not
particularly distracted by this indulgence, but the dieters could no longer think clearly, becoming consumed with
thoughts, such as “Why did I eat that?” and “What should I eat later today to make up for eating that?’

Another experiment published in 2010 found that women who restricted their caloric intake and recorded what
they ate exhibited elevated cortisol levels, a marker of biological stress. Even women who simply monitored their
meals without trying to restrict calories reported feeling more stressed, and they ended up gaining weight. The

bottom line is, for most people, that diets not only backfire, they also take a heavy toll on our physical and mental

What You Should Do

Start with your head: If you want to improve your body, you must also improve your mind-set. Decades of
research show that individuals who are dissatisfied with their bodies are less successful at losing weight. Studies
also show that it is possible for anyone to learn to feel good about his or her body.

In a 2014 study, women with eating disorders, including some who binged or who were overweight, received
compassion-focused therapy—an approach aimed at reducing feelings of shame and improving self-esteem. Over
the 12-week treatment, women who exhibited greater improvements in self-compassion and reductions in body
shame were also more likely to develop better eating habits.

One simple way to improve your self-esteem, according to many findings, is to write positive affirmations on a
regular basis. Happiness research has consistently shown that focusing on what you do like—“I have nice eyes”—
and on health rather than appearance-related goals—“I want to run a 5K this year”—can help you develop a
healthier mind-set and self-image.

Simple, slow and steady: When setting a weight loss goal, it is natural to want to accomplish it immediately.
Yesterday! But to maintain a more svelte figure, you need to make gradual, sustainable changes to your diet: for
example, drinking less alcohol and juice, substituting diet soda or seltzer for regular soda, and eating dessert on
four nights a week instead of seven. Making even small changes such as these may sound like a “diet,” which I
have told you to avoid, but it is not, for one important reason: this slow, steady approach allows you to adjust to a
new routine at your own pace without the intense effort and denial that typical diet plans require. Most people
trying to lose five to 50 pounds will benefit from this slow-to-moderate approach to weight loss, but it is important
to note that individuals whose health is at serious risk because of obesity will likely need more drastic measures
and should consult a physician.

A large body of research supports the idea that making simple, gradual changes to your eating patterns is the best
way to promote lasting weight loss. Robust evidence for this approach comes from a 2008 study, which
demonstrated that overweight and obese adults who made very modest changes to their daily calorie intake and
physical activity levels lost four times more weight than those following regimens that involved more extreme
calorie restriction. The moderate group lost 10 pounds in one month, and they sustained the weight loss over the
next three months.

In support of this approach, a 2015 study published in PLOS ONE found that women who successfully modified
their diet and exercise habits over time set small, achievable behavior change goals, had realistic expectations
about their weight loss and were internally motivated to lose weight. The women who relapsed or failed to change
their habits tended to have unrealistic expectations, lower motivation and self-confidence, and less satisfaction with
their progress.

Some of the most compelling data on effective weight-loss strategies comes from the National Weight Control
Registry (NWCR), which surveyed more than 4,000 people who lost at least 30 pounds and kept it off for at least a
year. The best tactics, according to the seminal 2006 report, included self-monitoring, such as limiting certain
foods, keeping track of portion sizes and calories, planning meals and incorporating exercise into the daily routine.

Such advice may appear to conflict with the research I described earlier on the pitfalls of restriction and mental
fatigue, but the truth is, to lose weight, it is important to find the right balance. For instance, before making
changes to your diet, you need to understand your current eating patterns, which may require considerable thought
and attention. Most overweight individuals, when they are not trying to diet, tend to eat erratically—consuming
junk food, snacking a lot and indulging cravings on a whim. Becoming aware of these habits, the good and bad,
will allow you to tailor them.

As you begin to make small tweaks to your daily eating, start to plan a few meals you like that you can cycle
through on a regular basis, so you don’t have to think too hard about what you’re going to eat every day.

According to the NWCR data, people who plan their meals are 1.5 times more likely to maintain their weight loss.
The NWCR data also show that limiting the variety of foods you eat can help you sustain your weight. You don’t
have to eat the same foods every day, but generally reducing the array of options makes grocery shopping less

Work it out: We all know by now that exercise is essential for all-around health. Yet study after study shows
that working out is not terribly effective for weight loss on its own. When combined with better eating habits,
however, exercise appears to help people slim down. A 2012 study looked at the effects of diet or exercise, or both
or neither, in a group of overweight or obese postmenopausal women. Dieters could consume between 1,200 to
2,000 calories a day, depending on their initial weight, and exercisers ramped up to 45 minutes or more of cardio
five days a week. After 12 months, those in the combined diet and exercise group lost the most weight—about 19.5
pounds—although the diet-only group was not far behind, losing 15.8 pounds. Those who only exercised lost 4.4
pounds, and the control group, who didn’t exercise or eat differently, lost 1.5 pounds over the year.

Once your goal weight is achieved, exercise may be crucial for keeping the scale steady. Most people who have
slimmed down report that routine physical activity is an important part of their maintenance regimen. Exercise has
many physiological benefits; it even appears to moderate the brain’s reaction to pleasurable foods. In a small 2012
study, overweight or obese participants underwent an initial brain scan while looking at images of food. Then they
were put on a six-month exercise regimen. At six months, the exercisers showed decreased activity in the insula,
which regulates emotions, in response to images of palatable treats. They did not, however, report changes in
dietary restraint, food cravings or hunger, suggesting that the neural effects are subtle—perhaps helpful during
weight maintenance but not strong enough to induce weight loss.
Incorporating exercise into your life should be a gradual process. You don’t have to run marathons to reap
psychological and physical rewards. Going for a lunchtime walk or biking to work is a way to integrate activity
into your daily routine. You can also increase your movements in small ways by taking the stairs instead of riding
the elevator or washing your car instead of driving through the car wash. Being disciplined is important, but
making exercise fun and sustainable is also essential.

Don’t do it alone: Receiving social support is key to losing weight. Consulting a physician or nutritionist is one
way to elicit support and provide greater accountability. Research also demonstrates the role romantic partners play
in encouraging weight loss. In my work, I have found that men are better able to adopt and stick with healthier
eating habits when they receive support and encouragement from their spouse. Similarly, friends, co-workers and
online weight-loss buddies can keep you on track by offering inspiration, praise and partners in crime. More
systematic help has been shown to be useful, too, such as becoming a member of Weight Watchers or other support
groups or participating in the community of users of smartphone apps such as MyFitnessPal, Lose It! or SmartenFit
(the last of which I co-developed).

After decades of diet studies, we can no longer ignore the fact that the preponderance of evidence points toward
these small, sustainable steps as the best way to lose weight. That message may not be as sexy or exciting as the
latest fad diet, but the science is clear: moderation leads to changes that will last for the rest of your life. Creating
good habits takes time, patience and resolve, and you will inevitably encounter setbacks along the way. But the key
is to never give up—and in a few short months, you may find yourself on the road to the body and active way of
life you’ve always dreamed about.

Weighing In on Popular Diets

The small, moderate changes I recommend in this article are the best way to lose weight over the long term, but the
allure of popular diets remains strong. A small percentage of people do find long-term success on these diets, so it is hard
to discount such strategies entirely—although the evidence suggests that a moderate approach will give you better odds
of meeting your goals. Here’s the lowdown on a few popular diets:


The Plan: Based on the premise that we’d be better off eating as our hunter-gather ancestors did, the Paleo diet
prescribes a diet of veggies, fruits, meat and nuts; it eliminates dairy, whole grains, refined sugars, processed foods
and legumes.

The Skinny: Our current food environment is not compatible with that of our ancestors. Eating as the Paleo diet
dictates is unrealistic long term because it is so restrictive, making an enjoyable social life almost impossible.
Cutting out so many food groups leads to distressing cravings for most people, too.


The Plan: The diet calls for high quantities of protein and very limited carbohydrate and sugar intake. Doing
this increases our ability to burn fat.

The Skinny: Many studies show that this strategy works well for weight loss in the short term, but most people
end up gaining back the weight over time. Such results are a good example of how extreme restriction tends to


The Plan: Eat normally for five days a week and fast for two, with women allowed 500 calories and men
allowed 600 on fast days.

The Skinny: The 5:2 diet has received a lot of recent attention. Preliminary evidence in humans and in mice
suggests that it may aid weight loss, but the jury is still out. The main problem is that 500 or 600 calories will
likely leave you unsatisfied at the end of the day. If you’re hungry, you’re going to crave food, especially energy-
dense treats, more so than if you ate moderately. Once you give into your hunger, the “what the hell effect” will
likely set in.


The Plan: Weight Watchers emphasizes making healthy and sustainable lifestyle changes by consuming
balanced meals. The plan highlights fruits and vegetables, and the meals can be tailored to an individual’s likes. No
foods are off-limits.

The Skinny: Weight Watchers does a lot of things right. From a nutritional and psychological standpoint, the
recommendations to enlist peer support and not to eliminate particular food groups agree with the advice I offer.
Some people, however, may find the cost prohibitive—there are registration and weekly fees—and research
suggests that weekly weigh-ins can be counterproductive, making some dieters distraught if the scale doesn’t
match their expectations. —C.N.M.

--Originally published: Scientific American MIND 26(5); 46-52 (September/October 2015).

Behavior: The Additional Key to Weight-Loss
by David H. Freedman

Obesity is a national health crisis–that much we know. If current trends continue, it will soon surpass smoking in
the U.S. as the biggest single factor in early death, reduced quality of life and increased health care costs.

A third of adults in the U.S. are obese, according to the Centers for Disease Control and Prevention, and another
third are overweight, with Americans getting fatter every year. Obesity is responsible for more than 160,000
“excess” deaths a year, according to a study in the Journal of the American Medical Association. The average
obese person costs society more than $7,000 a year in lost productivity and extra medical treatment, say
researchers at George Washington University. Lifetime-added medical costs alone for a person 70 pounds or more
overweight amount to as much as $30,000, depending on race and gender.
All this lends urgency to the question: Why are extra pounds so difficult to shed and keep off? It does not seem
as though it should be so hard. The basic formula for weight loss is simple and widely known: consume fewer
calories than you expend. And yet if it really were easy, obesity would not be the nation’s number-one lifestyle-
related health concern. For a species that evolved to consume energy-dense foods in an environment where famine
was a constant threat, losing weight and staying trimmer in a modern world of plenty fueled by marketing
messages and cheap empty calories is, in fact, terrifically difficult. Almost everybody who tries to diet seems to fail
in the long run—a review in 2007 by the American Psychological Association of 31 diet studies found that as
many as two thirds of dieters end up two years later weighing more than they did before their diet.

Science has trained its big guns on the problem. The National Institutes of Health has been spending more than
$800 million a year on studies to understand the metabolic, genetic and neurological foundations of obesity. In its
strategic plan for funding obesity research, published in 2011, the NIH placed at the top of the list of research
opportunities the investigation of basic biological processes related to obesity, including “specific roles of organs,
tissues, and molecules in the development of obesity” and “genes, epigenetics, and critical periods in human

This research has provided important insights into the ways proteins interact in our body to extract and distribute
energy from food and produce and store fat; how our brain tells us we are hungry; why some of us seem to have
been born more likely to be obese than others; and whether exposure to certain foods and toxic substances might
modify and mitigate some of these factors. The work has also given pharmaceutical companies numerous potential
targets for drug development. What the research has not done, unfortunately, is make a dent in solving the national

Maybe someday biology will provide us with a pill that re adjusts our metabolism so we burn more calories or
resets our built-in cravings so we prefer broccoli to burgers. But until then, the best approach may simply be to
build on reliable behavioral-psychology methods developed over 50 years and proved to work in hundreds of
studies. These tried-and-true techniques, which are being refined with new research that should make them more
effective with a wider range of individuals, are gaining attention. As the NIH puts it in its proposed strategic plan
for obesity research: “Research findings are yielding new and important insights about social and behavioral
factors that influence diet, physical activity, and sedentary behavior.”

The Biology of Obesity

The National Institutes of Health has spent more than $800 million a year on studies to understand the neurological,
metabolic and genetic foundations of obesity. In the process, scientists have uncovered complex biochemical pathways
and feedback loops that connect the brain and digestive system; a new appreciation for the regulatory functions of fat
tissues; subtle hereditary changes that make some groups more prone to obesity than others; and the strong possibility
that exposure to certain foods and toxic substances might modify and mitigate some of these factors. Given that it will
likely take decades to understand the various causes of obesity, more surprises are no doubt in store.

Credit: Illustration by Peter and Maria Hoey.

How We Got Here

The desperation of the obese and overweight is reflected in the steady stream of advice pouring daily from
sources as disparate as peer-reviewed scientific journals, best-selling books, newspapers and blogs. Our appetite
for any diet twist or gimmick that will take the pounds off quickly and for good seems to be as insatiable as our
appetite for the rich food that puts the pounds on. We, the public, love to believe in neat fixes, and the media oblige
by playing up new scientific findings in headline after headline as if they are solutions.

It does not help that the scientific findings on which these headlines are based sometimes appear to conflict. For
example, a 2010 study in the American Journal of Clinical Nutrition linked weight loss to increased dairy intake,
although a 2008 meta-analysis in Nutrition Reviews found no such link. A 2010 paper in the Journal of
Occupational and Environmental Medicine postulated a connection between job stress and obesity, but another
report that year in the journal Obesity concluded the two are uncorrelated. Part of the problem is that obesity
researchers are in some ways akin to the metaphorical blind men groping at different parts of the elephant: their
individual study findings address only narrow pieces of a complex puzzle.
When the research is taken together, it is clear that the obesity fix cannot be boiled down to eating certain kinds
of food or taking other simple actions. Many factors contribute to the problem. Some are environmental—the
eating habits of your friends, what food is most available in your home and your local stores, how much
opportunity you have to move around at work. Others are biological, such as genetic predispositions for storing fat,

having higher satiety thresholds or having more sensitive taste buds. Economics and marketing play roles, too.
Junk food is much cheaper than fresh produce. And food companies are masters at manipulating our social nature
and our evolutionary “programming” to steer us toward unhealthy but profitable fare. That is why the narrow “eat
this” kinds of solutions, like all simple solutions, fail.

When we go on diets and exercise regimens, we rely on willpower to overcome all these pushes to overeat
relative to our activity level. And we count on the reward of getting trimmer and fitter to keep us on the wagon. It
is rewarding to lose the weight, of course. Unfortunately, time works against us. As the weight comes off, we get
hungrier and develop stronger cravings and become more annoyed by the exercise. Meanwhile the weight loss
inevitably slows as our metabolism tries to compensate for this deprivation by becoming more parsimonious with
calories. Thus, the punishment for sticking to our regimen becomes increasingly severe and constant, and the
expected reward recedes into the future. “That gap between the reinforcement of eating and the reinforcement of
maybe losing weight months later is a huge challenge,” says SungWoo Kahng, a neurobehaviorist who studies
obesity at the University of Missouri.

We would be more likely to stick with the regimen if it remained less punishing and more reliably rewarding. Is
there a way to make that happen?
From Biology to Brain

The most successful way to date to lose at least modest amounts of weight and keep it off with diet and exercise
employs programs that focus on changing behavior. The behavioral approach, tested over decades, involves
making many small, sustainable adjustments in eating and exercise habits that are prompted and encouraged by the
people and the rest of the environment around us.

The research in support of behavioral weight-loss approaches extends back more than half a century to Harvard
University psychologist B. F. Skinner’s development of the science of behavioral analysis. The field is founded on
the notion that scientists cannot really know what is going on inside a person’s brain—after all, even functional
MRIs, the state of the art for peering into the mind, are crude, highly interpretable proxies for cognition and
emotion that reduce the detailed firing of billions of neurons in complex circuits to a few blobs of color. But
researchers can objectively and reproducibly observe and measure physical behavior and the immediate
environment in which the behavior occurs, allowing them to identify links between environment and behavior.
That typically includes trying to spot events or situations that may be prompting or triggering certain behaviors and
noting what may be rewarding and thus reinforcing of some behaviors or punishing and thus inhibiting of others.

The effectiveness of behavioral interventions has been extensively documented for many disorders and problem
behaviors. A 2009 meta-analysis in the Journal of Clinical Child & Adolescent Psychology concluded that “early
intensive behavioral intervention should be an intervention of choice for children with autism.” A systematic
review sponsored by the U.S. Preventive Services Task Force concluded that even brief behavioral-counseling
interventions reduced the number of drinks taken by problem drinkers by 13 to 34 percent for as long as four years.
Studies have found behavioral-intervention successes in challenges as diverse as reducing stuttering, increasing
athletic performance and improving employee productivity.

To combat obesity, behavioral analysts examine related environmental influences. Which external factors
prompt people to overeat or to eat junk food, and which tend to encourage healthful eating? In what situations are
the behaviors and comments of others affecting unhealthful eating? What seems to effectively reward eating
healthfully over the long term? What reinforces being active? Behaviorally focused studies of obesity and diets as
early as the 1960s recognized some basic conditions that seemed correlated with a greater chance of losing weight
and keeping it off : rigorously measuring and recording calories, exercise and weight; making modest, gradual
changes rather than severe ones; eating balanced diets that go easy on fats and sugar rather than dropping major
food groups; setting clear, modest goals; focusing on lifelong habits rather than short-term diets; and especially
attending groups where dieters could receive encouragement to stick with their efforts and praise for having done
If these strategies today sound like well-worn, commonsense advice, it is because they have been popularized
since 1963 by Weight Watchers, which was founded to provide support groups for dieters. Weight Watchers later

added other approaches and advice in keeping with the findings of behavioral studies and billed itself as a
“behavior-modification” program. “Whatever the details are of how you lose weight, the magic in the sauce is
always going to be changing behavior,” says Karen Miller-Kovach, former chief science officer of Weight
Watchers. “Doing that is a learnable skill.”

Studies back the behavioral approach to weight loss. A 2003 review commissioned by the U.S. Department of
Health and Human Services found that “counseling and behavioral interventions showed small to moderate degrees
of weight loss sustained over at least one year”—a year being an eon in the world of weight loss. An analysis of
eight popular weight-loss programs published in 2005 in the Annals of Internal Medicine found Weight Watchers
(then in its pre-2010 points-overhaul incarnation) to be the only effective program, enabling an average reduction
of 3 percent body weight maintained for the two years of the study. Meanwhile a 2005 JAMA study found that
Weight Watchers, along with the Zone diet (which similarly recommends a balanced diet of protein, carbohydrates
and fat), achieved the highest percentage (65 percent) of one-year diet adherence among several popular diets,
noting that “adherence level rather than diet type was the key determinant of clinical benefits.” A 2010 study in the
Journal of Pediatrics found that overweight children receiving one year of behavioral therapy dropped 1.9 to 3.3
units more in body mass index, a height-weight relation correlated to body fat, than control subjects did. The
Pediatrics report noted that “more limited evidence suggests that these improvements can be maintained over the
12 months after the end of treatments.”

A 2010 study in Obesity found that continuing members of Take Off Pounds Sensibly (TOPS), a national,
nonprofit, behaviorally focused weight-loss organization, maintained a weight loss of 5 to 7 percent of their body
weight for the three years of the investigation. The U.K.’s Medical Research Council declared in 2010 that its own
long-term study had shown that programs based on behavioral principles are more likely to help people take and
keep the weight off than other approaches. (The study was funded by Weight Watchers, but without its
Weight Watchers and other widely marketed programs tend to fall short, however, in enlisting a full range of
behavioral techniques and customizing them to meet the varied needs of individuals. They do not routinely provide
individual counseling, adapt their advice to specific challenges, assess environmental factors in a member’s home,
workplace or community, provide much outreach to members who do not come to meetings, or prevent their
members from shooting for fast, dramatic, short-term weight loss or from restricting food groups. In search of
profits, Weight Watchers sometimes even mildly panders to these self-defeating notions in its marketing. “Some
people join us to drop 10 pounds for a high school reunion,” Miller- Kovach says. “They achieve that goal, then
stop coming.”

To close that gap, a number of researchers have turned their attention in recent years to improving, expanding
and tailoring behavioral techniques, with encouraging results. For example, Michael Cameron, chief clinical officer
of Pacific Child & Family Associates, a national group of clinics for children with special needs, has authored
more than 20 articles in peer-reviewed journals documenting the effectiveness of a wide range of behavioral
interventions. A former faculty member at Harvard Medical School’s teaching psychiatric hospital, Cameron in
2011 conducted a yearlong, four-person study—behavioral analysts generally do very small group or even single-
subject studies to more closely tailor the intervention and observe individual effects—in which the subjects met
together with him via online video-conferencing for reinforcement, weighed themselves on scales that transmitted
results via wireless networks, and had their diets optimized to both reduce caloric density and address individual
food preferences. Favorite foods were used as a reward for exercise. The subjects lost 8 to 20 percent of their body
weight, and Cameron says they and the several other people he has worked with outside the study have all kept the
weight off.

Matt Normand, a behavioral analyst at the University of the Pacific, has investigated ways to more precisely
track subjects’ calorie intake and expenditure. He collects receipts of their food purchases, provides checklists to
record what they eat, and uses pedometers and other devices to measure their physical activity. He then gives
participants daily detailed accounts of their calorie flow. In one published study, Normand showed that three of
four subjects reduced calorie intake to recommended levels.

Richard Fleming, a researcher at the University of Massachusetts Medical School’s Shriver Center, has in
Obesity looked at ways to encourage parents to steer their children to healthier choices. He has found, among other

techniques, that showing parents in person what appropriate serving sizes of foods look like on plates is helpful.
Another successful Fleming trick: letting children pick out a small treat at a food store—as long as they walk there.
“Kids can really respond to that reward for being active,” he says.

Why are behavioral interventions effective? Laurette Dubé, a lifestyle psychology and marketing researcher at
McGill University’s Faculty of Management, notes that our environment is currently one in which ubiquitous,
sophisticated marketing efforts prey on our need for sensory gratification as well as our vulnerability to
misinformation. In addition, the poor eating and exercise habits we observe in our friends, family and colleagues
encourage us to follow suit. In essence, behavioral interventions seek to reconfigure this environment into one in
which our needs for information, gratification and social encouragement are tapped to pull us toward healthy food
and exercise choices rather than away from them. “When we are getting the right messages in enough ways, we
have a better chance of resisting the urge to eat more than we need,” Dubé says.

Changing Policy
There is no one-size-fits-all solution, behavioral or otherwise, to the problem of obesity. But although behavioral
interventions work best when they are customized to individuals, mass-market behavioral approaches such as
TOPS and Weight Watchers are at least fairly effective. Why don’t more people lose weight with them? The main
reason is that people simply do not sign up for them, often because would-be weight losers are chasing fad diets or
supplements or have read that obesity is locked into our genes. Weight Watchers, by far the most popular
behavioral weight-loss program, counts only 600,000 meeting-attending members in its ranks in North America.
That means that in the U.S., fewer than one out of 100 obese people and about one out of 200 overweight people
are part of a formal behavioral-modification program.

Public policy may be changing, however. The U.S. Surgeon General’s office and the CDC have both publicly
lined up behind behavioral approaches as the main weapon in what is becoming a war on obesity. First Lady
Michelle Obama’s Let’s Move campaign against childhood obesity consists almost entirely of finding ways to
encourage children to eat lower-calorie foods, to become more active, and to enjoy doing it. San Francisco’s 2010
ban of free toys in fast-food meals for kids suggests that more officials may be ready to pressure the food industry
into easing up on what are essentially obesity-supportive marketing tactics. To encourage people in poorer,
disproportionately over weight communities to buy healthier food, the White House has proposed subsidizing the
costs of fruits and vegetables.

Approaching the problem from the other direction, former New York City mayor Michael Bloomberg advocated
modifying food-assistance programs to restrict the purchase of high-sugar beverages and supported a ban, passed
by the city’s board of health, on extra-large servings of sugary sodas. In 2014 voters in Berkeley, Calif., approved a
surtax of 1 cent per ounce on such drinks. New York City has also offered vouchers for buying produce at farmers’
markets to low-income families and incentives to stores to offer healthier fare.

Increasing access to behavior therapy would help, too. Many overweight people might need only online
behavioral monitoring, support and progress-sharing tools, which have proved moderately effective in studies.
Others may need much more intensive, more personal interventions of the kind Cameron is developing. Given that
obesity especially plagues the economically disadvantaged, fees for these programs may have to be heavily
subsidized by the government and health care insurers. A weekly session with a behavioral therapist costing $50
would amount to $2,500 a year, or a bit more than a third of the $7,000 a year societal and medical costs of obesity
—and the sessions might be needed for only a year or two to establish new, permanent eating and exercise habits,
whereas the savings would continue on for a lifetime.

It is too soon to say whether the public will accept government efforts to push it toward healthier choices. San
Francisco’s ban on Happy Meal toys was initially vetoed by the mayor in response to angry reaction. Efforts by
Let’s Move to bring healthier food to school cafeterias have been intensely criticized by some as overly intrusive.
The courts threw out New York City’s ban on large sodas. And voters have rejected taxes on high-calorie
beverages in San Francisco and most other cities and states that have proposed them.
Even if such efforts are eventually fully implemented nationwide, there is no way of being sure they will
significantly reduce obesity. The current rate of obesity is far beyond any ever seen before on the planet, and thus a

large-scale solution will necessarily be an experiment in mass behavior change. But the research suggests that such
a grand experiment would be our best shot at fixing obesity and that there is reason to be hopeful it will succeed.
Given that more and more scientists, public policy experts and government officials seem eager to get it off the
ground, we may well have early findings within this decade.

Credit: Illustration by Peter and Maria Hoey.

--Originally published: Scientific American 304(2); 40-47 (February 2011).

Mental Floss: Your Brain on Exercise

Head Strong
by Ferris Jabr

On Valentine’s Day 2014 Elizabeth Droge-Young admitted herself to a hospital in Syracuse, N.Y. For more than
a year, she had been struggling with depression—not eating well and losing interest in the movies, books and
music that usually delighted her. She had withdrawn from her friends and was routinely missing classes at
Syracuse University, where she was a fifth-year graduate student in evolutionary biology. Some days that winter
she could not even make it out of bed, despite the fact that she had started taking antidepressants the previous fall.
In her darkest moments, obsessive and frightening thoughts of self-harm and suicide flooded her mind. “It was
horrible,” she recalls. “I felt very unsafe.” She realized she needed a serious intervention.

After a week and a half on suicide watch at the hospital, plus a stronger cocktail of medications, Droge-Young
returned home, taking an academic leave of absence for the remainder of the school year. For a while, she seemed
to be getting better. But when she went back to school in August, the unbearable sadness and dark impulses
resurfaced. This time she turned to a hospital in Saratoga Springs, N.Y., some two and a half hours away, which
offered a more holistic treatment. In addition to medication and counseling, her doctors prescribed a full schedule
of daily activities, such as arts and crafts and walks around the grounds. During her stay, a hospital therapist also
recommended exercise. So after her release, Droge-Young started going to the gym three to five times a week,
walking and jogging on the treadmill, lifting weights and attending Zumba, a popular dance fitness class.

“It was empowering,” says Droge-Young, now 33 and working as a freelance science writer in Providence, R.I.
“It really helped with my mood. There’s something wonderful about the mind-body connection exercise provides.
Using weight machines or jogging on the treadmill allows you to be self-reflective: ‘Look at the strength and
endurance I have. This is something positive about myself.’ And the dancing was joyful—just being able to move
around in a way that was free and felt good.” Since incorporating exercise into her regimen for managing
depression, Droge-Young has never relapsed to the point of requiring another hospitalization. To this day, she
considers dance and riding on a stationary bike to be a crucial component of her treatment.

The fact that exercise improves physical health is so well known as to be a platitude. Decades of research
demonstrate that regular exercise lowers the risk of many illnesses—heart disease, obesity, diabetes, cancer—and
extends the average life span. In contrast, the benefits of exercise for mental health are not quite so obvious or well
publicized. We work out to “get in shape,” and some of us depend on bike rides, neighborhood jogs or yoga to help
clear our mind and relieve stress. But how often do we seriously consider exercise as a viable treatment for mental
illness, one just as effective as medication or counseling? Can a steady routine of physical workouts really help to
keep psychological disorders in check?

In the case of depression, the collective evidence to date suggests that the answer is an emphatic yes. Exercise is
by no means a panacea, and in severe cases of depression, it may be futile on its own. But scores of experiments
now show that exercise is much more than a temporary distraction from mental woes or some ultimately
inconsequential palliative. It appears to combat depression in a number of ways: by strengthening our biochemical
resilience to stress, encouraging the growth of new brain cells, bolstering self-esteem and possibly even
counterbalancing an underlying genetic risk for mental illness. For most people with mild to moderate depression,
exercise is one of the strongest, safest, most practical, most affordable and even enjoyable treatments available.

“I am a big believer in the value of physical activity,” says clinical psychologist James Blumenthal of Duke
University. “The majority of evidence suggests that a certain subset of patients can benefit just as much with

exercise, if not more, than with medication.” Psychiatrist Madhukar Trivedi of the University of Texas
Southwestern Medical Center, who has studied the relation between exercise and mental health for more than 15
years, agrees: “We have now generated a whole big body of literature about exercise as a treatment for depression.
We’ve looked at dose, at adding exercise as an augmentation treatment, at specific biomarkers associated with
improvement. We have the studies to show that something really powerful and interesting is going on.”

On the Strength of the Evidence

Major depression—an illness characterized by a persistent low mood or loss of interest in typically pleasurable
activities, often accompanied by insomnia, fatigue, poor concentration or feelings of worthlessness—is one of the
leading causes of disability and death around the globe, according to the World Health Organization. At any given
time, it afflicts around 350 million people worldwide and 18 million people in the U.S. Only a fraction of sufferers
seek help, and of those, only a third respond to standard treatment, which is usually counseling and medication.
Antidepressant drugs are often costly and can have serious side effects, driving many patients to search for less
expensive, safer, more natural solutions. In a survey of more than 2,000 U.S. adults published in 2001, more than
half of the respondents with depression said that they had turned to some kind of alternative treatment, such as
yoga, herbal medicines or acupuncture.
Psychologists and clinicians have studied exercise as an alternative treatment for depression for at least 30 years.
Blumenthal was one of the pioneers. In the 1980s, while researching how exercise helps patients with
cardiovascular disease, he and his colleagues noticed an inadvertent secondary benefit: working out seemed to
improve people’s moods and reduce symptoms of depression. They decided to investigate. One of their early
studies, published in 1999, tracked the health of 156 elderly men and women diagnosed with depression as they
exercised regularly or took antidepressants, or both. After 16 weeks, all three groups had improved equally, but
relapse rates were lowest among patients who exercised.

In a follow-up study, published a decade later, they divided more than 200 adults with depression into four
groups, each receiving a different intervention: supervised exercise classes, exercise at home, medication or
placebo. They found that patients engaging in supervised exercise fared better than those working out at home and
achieved nearly equivalent remission rates as those taking antidepressants: 45 versus 47 percent, respectively. By
comparison, the home exercise group reached a 40 percent remission rate and the placebo group, 31 percent.

More recently, in a similar study in 2015, Swedish scientists assigned 946 patients with mild to moderate
depression to one of three 12-week treatments: thrice-weekly sessions of yoga, aerobics or strength training;
Internet-based cognitive-behavioral therapy; or standard counseling plus medication. Patients in all groups
improved, but those engaging in exercise experienced the greatest benefits. Internet-based therapy came in as a
close runner-up, but the typical treatment plan lagged behind both alternatives.

To date, numerous meta-analyses have kept score on the accumulating data. They do not all agree: a few have
found no indication that exercise is helpful or have found that it offers only very small effects or greatly diminished
benefits in the long term. But most have reached similar optimistic conclusions. A 2013 review by the nonprofit
organization Cochrane, regarded as a leader in evidence-based medicine, concluded that exercise is just as effective
a treatment for depression as medication and counseling.

A recent meta-analysis, published in 2016, echoes Cochrane’s finding. A team of international researchers
examined 25 of the most rigorous experiments and determined that exercise, especially moderate to vigorous
aerobic exercise under professional supervision, is indeed a potent treatment for depression. When they adjusted
their analysis to account for weak studies—those most prone to some kind of experimental bias—they found an
even stronger effect, suggesting that some previous meta-analyses may have underestimated exercise’s benefits for
mental health. The researchers further calculated that it would take at least 1,000 contradictory studies to negate the
affirming evidence that has piled up so far. Yet another review computed that when exercise is used to treat
depression, success rates increase by as much as 67 to 74 percent.
How Much Is Enough?

Some researchers have attempted to figure out what types of exercise and intensity levels are most effective as

an antidepressant. In a frequently cited study from 2005, for example, Trivedi and his colleagues tracked the health
of 80 adults with mild to moderate depression for three months as they exercised three to five times a week on a
treadmill or stationary bicycle at low intensity (seven kilocalories per kilogram per week) or at a higher intensity,
as recommended by public health authorities (17.5 kilocalories per kilogram per week). At the end of the three
months, the adults who exercised at the higher intensity had lessened the severity of their depression by 47 percent,
compared with only 30 percent for the low-intensity group and 29 percent for a group who engaged in stretching
rather than aerobic exercise.

On the basis of studies such as this one, some psychologists, clinicians and health authorities have gone as far as
publishing specific recommendations. Trivedi prescribes three to five 45- to 60-minute sessions of aerobic exercise
(walking, running, cycling, or using a treadmill, stationary bike or elliptical trainer) each week at an intensity of 50
to 85 percent maximum heart rate. “The ideal is probably at least 16 kilocalories per kilogram of body weight,
which works out to 1,200 to 1,500 kilocalories each week for average body weight,” Trivedi says. “If you can talk
to your spouse on the phone, you’re not working out at the right intensity.”

Likewise Central Queensland University exercise psychologist Robert Stanton advises 30- to 40-minute sessions
of aerobic exercise—walking, cross training or stationary cycling—three to four times a week at low to moderate
intensity for at least nine weeks. And the National Institute for Health and Care Excellence advocates group-based
physical activity programs for patients with mild to moderate depression, consisting of at least three 45-minute
sessions a week for at least 10 weeks.
Other experts, however, think it may be too soon to get so specific. A 2013 review paper, for instance, concluded
that both cardiovascular and resistance exercise, either alone or in combination, are effective at treating depression
but that there are not yet enough data to definitively favor one form of physical activity over another. “Which
exercise has the best mood effects, and what intensity is best? Does it work better alone or combined with other
treatments? We don’t know for certain yet,” says psychologist Michael Otto of Boston University, who has studied
both the emotional and cognitive benefits of exercise. “We can make some general suggestions, but we still need
more data to be confident about the specifics.”

Why Exercise Works

In the past decade scientists have uncovered numerous details about how exercise alters the brain, and the body
as a whole, in ways that alleviate and protect against depression. The second you start running, pedaling or lifting a
dumbbell, your body’s chemistry begins to change. Exercise boosts your heart rate, sending blood, oxygen,
hormones and neurochemicals surging through the body. In the moment, the body responds to exercise as a kind of
stress—but it is ultimately beneficial. Some evidence suggests that habitual moderate exercise rewires the brain
and immune system to better cope with physical and mental strain. The better the body becomes at dealing with
stressors of all kinds, the lower the risk of a depressive episode. In fact, many researchers think of depression as a
disorder of managing stress.

Exercise also seems to mimic some of the chemical effects of antidepressant medication. Based on increasing
evidence, some scientists argue that certain cases of depression result from the impaired growth of both brain cells
and the connections between them. Studies have documented the atrophy and loss of neurons in brain regions such
as the amygdala, hippocampus and prefrontal cortex in patients with major depression. Antidepressants that
increase levels of serotonin and other neurotransmitters might work by reinvigorating neural proliferation, a
process that depends in part on a molecule called brain-derived neurotrophic factor (BDNF). In studies with both
animals and people, exercise enhances the production of BDNF.

In one 2001 study, for example, rats given an antidepressant and the opportunity to run produced higher levels of
BDNF compared with animals that only ran or only received medication. Moreover, they were better at enduring a
stressful experience, swimming for longer in an inescapable water tank before giving up—a test designed to
approximate the onset of depression. In an analogous human study in 2016, Brazilian researchers divided 57 adults
taking the antidepressant sertraline for moderate to severe depression into two groups: one attended four weekly
sessions of aerobic activity for 28 days, and the other did not exercise. Symptoms abated similarly in both groups,
but the exercise group improved on lower doses of antidepressants. The authors suspect that exercise enhanced the
biochemical effects of the drugs. Similar studies have shown that simply recommending healthy lifestyle changes,

such as establishing better sleep routines and getting more exercise, can dramatically boost the efficacy of
antidepressants from a mere 10 percent remission rate with the drugs alone to a 60 percent remission rate.

And in a small but intriguing 2015 study, physician Helmuth Haslacher and his colleagues at the Medical
University of Vienna in Austria compared the mental health and genomes of 55 elderly marathon runners and
endurance bicyclists with those of 58 nonathletes. Among the nonathletes, they found a statistically significant
correlation between the number of depressive symptoms these individuals experienced and a particular gene
variant that interferes with normal BDNF production. Among the athletes, however, there was no such correlation.
The researchers concluded that by stimulating BDNF production, long-term, vigorous aerobic exercise might
actually counteract a genetic susceptibility to depression.

Neurobiology may also explain why, in addition to exercise countering depression, the inverse seems to be true:
correlations in epidemiological surveys suggest that physical inactivity, while sometimes the result of depression,
may also be a major risk factor for subsequently developing it. In a 2014 study of more than 6,000 elderly U.K.
citizens, the more time they spent watching television, the more likely they were to report symptoms of depression
(although this was not true for other sedentary activities such as reading). Those who participated in some form of
vigorous physical activity at least once a week experienced less depression. Likewise, a 2015 survey of nearly
5,000 Chinese college students found that the more time a student spent in front of a TV or computer screen, the
more likely he or she was to have depressive symptoms. In contrast, the risk for depression dropped the more
physically active a student was, regardless of age, gender or residential background. A meta-analysis of 24 studies,
involving nearly 200,000 participants, reached the same conclusion: sedentary behavior was associated with an
increased risk of depression. On average, active people are 45 percent less likely to be depressed than inactive
people, according to the U.S. Office of Disease Prevention and Health Promotion.

The Feel-Good Factor

Beyond these physiological reasons, many social and psychological factors help to explain why working out can
alleviate symptoms of depression. In comprehensive interviews, people who have struggled with the disorder say
that exercise energizes them, gives them a sense of purpose and achievement, elevates their self-esteem and mood,
regulates appetite and sleep cycles, and distracts them from negative thoughts. For those who exercise in a group, it
can also provide a welcome opportunity for social interaction.

First, though, many people with depression must overcome a severe lack of motivation. “We need to educate
people and give them tools to help monitor their progress,” Trivedi says. “We make patients log in and
communicate with us. If we find out they have skipped a day, we work with them to solve the problem and make
sure that by the end of week, they complete their regimen.” Jennifer Carter, director of sport psychology at the
Ohio State University Wexner Medical Center, has come up with a bevy of practical tips, among them: “Notice the
facts,” she advises. “For example, there are 1,440 minutes in a day. Perhaps you can find 30 of those to exercise.”

Getting over that initial hurdle of low motivation seems to depend in particular on how much satisfaction and
self-agency people experience while working out. “Enjoyment is fundamentally linked to how much people stick
with exercise,” Otto says. “I want them to do what is most fun and entertaining, whatever that might be.” Research
suggests that exercise as therapy succeeds when people choose the type and intensity. Most people prefer a
moderate intensity, around or just below the ventilatory threshold—the point at which breathing becomes
noticeably labored. In 2011 Patrick Callaghan, head of health sciences at the University of Nottingham in England,
and his colleagues asked 38 women with depression to exercise on treadmills in small groups three times a week,
either at a prescribed intensity or one they personally selected. After a month, the women who chose how much to
exert themselves had lower levels of depression and higher self-esteem compared with the other group.

Despite the mounting evidence that exercise can remedy some forms of depression, skepticism persists in
academia and health care, Trivedi notes. “There is this general bias that exercise is not a bona fide treatment—it’s
just something you should do in addition to treatment, like trying to sleep and eat well,” he says. “Even though
recognition of exercise as a treatment is increasing,” only some health insurance companies pay for gym time, he
explains, and when they do, they often offer small temporary discounts. “I can prescribe a drug that costs $200 and
insurance will pay, but they won’t give $40 to open a gym membership.”

Patients will need to change their thinking as well. “It can be hard for patients to think of exercise as a form of
treatment,” Otto comments. “We usually exercise to look good at the beach, to lose weight.” Most individuals do
not understand the degree to which exercise can reshape their mood, too. “Even if you feel like pulling in and
doing nothing, exercise pushes you out,” he adds. “Depression makes you feel like everything you’re about to do is
useless and pointless. That’s exactly what exercise fights—you have to get up and go.”

Looking for Motivation? Remember These Tips

10 minutes of exercise is better than none.
Set yourself challenging but realistic goals.
If you aren’t exercising at all, start by taking the stairs instead of the elevator or call a friend to schedule a walk once
or twice a week.
Identify what motivates you: if you are competitive, join a recreational sports league; if you are a social butterfly, join
an exercise class; if you are a nature buff, go on a hike.

--Originally published: Scientific American MIND 28(1); 26-31 (January/February 2017).

Take 2 Hikes and Call Me in the Morning
by Nathaniel P. Morris

A growing trend in medicine has doctors prescribing visits to parks for their patients. A pediatrician named
Robert Zarr at Unity Health Care in Washington, D.C., has worked with the National Park Service and other
institutions to create DC Park Rx, an initiative that helps health care providers prescribe activity in outdoor spaces
to patients. And National Geographic recently highlighted the rise of this practice in Vermont, where doctors are
now prescribing thousands of visits to state parks. In the last several years park prescription programs have spread
nationwide, from Maine to California, South Dakota to New Mexico.

Proponents of these programs promote outdoor activity as a means of tackling chronic medical conditions like
obesity, high blood pressure and type 2 diabetes. But park prescriptions also hold considerable promise for patients
suffering from mental health issues.

A large body of evidence suggests that exposure to nature may promote mental well-being. A 2010 meta-
analysis of 10 studies including over 1,200 participants found people who exercised in green environments
demonstrated significant improvements in mood and self-esteem. A 2011 systematic review looked at 11 trials that
compared indoor and outdoor activity, finding that exercise in natural settings was “associated with greater feelings
of revitalization and positive engagement, decreases in tension, confusion, anger and depression, and increased
energy.” Another recent review of studies found activity in natural environments correlated with reductions in
negative emotions like sadness, anger and fatigue.

Some studies suggest interactions with parks and other natural settings may influence rates of mental illness in
the population. For example, a study of over 160,000 people in South Korea found those living in areas with the
lowest amount of parks and green spaces had 20 percent greater odds of depressive symptoms and 28 percent
greater odds of suicide attempts compared with those living in areas with the highest amount of natural spaces,
even after controlling for potential confounders like age, gender and monthly income.

Researchers are trying to better understand the neuroscience behind why exposure to parks and other natural
settings might promote mental health. A study out of Stanford University, where I’m training as a resident
physician in psychiatry, used brain imaging to examine participants who walked in urban or natural environments;
the authors found those who went on a nature walk reported decreased rumination (that is, repetitive thoughts
focused on negative aspects of the self) and had lower activity in the subgenual prefrontal cortex, a region of the
brain associated with mental illness. These effects were not seen after urban walks.

Given these promising results, it’s not surprising to see burgeoning interest in park prescription programs and
other mental health treatments designed around exposure to nature. Researchers are exploring whether outdoor
activities like hiking or horticulture may help treat veterans suffering from post-traumatic stress disorder. Multiple
studies suggest outdoor exercise may be helpful in treating depression. Nature-assisted treatments have been
associated with improved outcomes for conditions like schizophrenia as well as decreased levels of health care
consumption among people with mental health issues.

How park prescriptions work may vary depending on the health care provider and the patient’s location. In the
model developed by DC Park Rx, clinicians can generate a prescription from a database that maps out local parks
for patients with recommended activities and park ratings. A number of prescription programs rolled out by states
now also waive park entrance fees for patients.

But park prescriptions aren’t panaceas just yet. Many patients, including those who are working multiple jobs,
unemployed or homeless, may not be able to travel or to take the time to enjoy the benefits of activity in nearby
parks. And although park prescriptions are popping up across the country, we still have little data to confirm
whether these programs have a meaningful impact on patients’ health—mental health or otherwise.

Another concern raised by National Geographic’s coverage of park prescriptions is the potential misuse of these
budding programs. In the article the chair of the Vermont Governor’s Council on Physical Fitness and Sports
chastised some doctors for writing park prescriptions for their staffs instead of their patients. Another doctor at the
University of Vermont Medical Center talked about how park prescriptions frequently end up stuffed into patients’
discharge paperwork without much discussion of what they’re for.

As a doctor specializing in mental health, I still see a lot of good that can come from these programs. Parks are
all around us, and a fair amount of evidence suggests they can help patients suffering from mental health issues.
And as Zarr of DC Park Rx has pointed out, visiting a park has fewer side effects and lower costs compared with
some of the medications we give our patients.
During my residency training, I often see patients lying on stretchers in emergency department hallways,
struggling to sleep in noisy intensive care units or sitting in windowless clinic rooms. Indeed, I wonder whether
these environments say something about the kinds of treatment that we provide.

Last month, I slipped away from the hospital during a weekend to do some hiking in a local park. As I walked
along a ridge, the sounds of my pager faded from my consciousness. I listened to the trees as the sun warmed my
face. A sense of calm came over me.

That felt like good medicine.

--Originally published: Scientific American Online, September 2017

Copyright 2
Title Page 3
Table of Contents 4
Introduction 5
SECTION 1 Breaking Biology: New Truths in Diet & Exercise 6
1.1 The Exercise Paradox 7
1.2 The Messy Truth about Weight Loss 12
1.3 The “True” Human Diet 18
1.4 Mind over Meal: Weight-Loss Surgery and the Gut-Brain
SECTION 2 The Skinny on Behavioral Intervention 24
2.1 Don’t Diet! 25
2.2 Behavior: The Additional Key to Weight-Loss 30
SECTION 3 Mental Floss: Your Brain on Exercise 36
3.1 Head Strong 37
3.2 Take 2 Hikes and Call Me in the Morning 42