Nur Aida Pratiwi - I1021161046 - Reguler A (Tugas Farmakokinetik) PDF
Nur Aida Pratiwi - I1021161046 - Reguler A (Tugas Farmakokinetik) PDF
NIM : I1021161046
Kelas : Reguler A
1. Diketahui konsentrasi obat plasma (Cp) yang diperoleh setelah pemberian bolus intravena
dosis 250 mg obat yang menunjukkan karakteristik model satu kompartemen dan dihilangkan
secara ekslusif oleh eksresi urin.
Jawaban :
b. k = ln C2-ln C1
t2-t1
= ln 30 – ln 54
2–1
= – 0,5877/jam
c. ln Ct = ln Co – k.t
ln 54 = ln Co - 0,5877.1
3,98 = ln Co – 0,5877
ln Co = 4,5677
Co = 96,32 µg/ml
d. Vd = Dosis i.v
Co
= 250 mg
96,32 mg/L
= 2,595 L
e. C75?
Dosis 2,5 mg/kg pada pasien 70 kg
Vd = Dosis i.v
Co
2,574 L = 175 mg
Co
2,547 Co = 175 mg
Co = 67,437 mg/L
= 67,437 µg/ml
ln Ct = ln Co – k.t
ln C75 = ln 67,437 – 0,587.1,25
C75 = 32,362 µg/ml
f. t?
Vd = Dosis i.v
Co
2,574 L = 275 mg
Co
Co = 107,003 µg/ml
ln Ct = ln Co – k.t
ln 20 = ln 107,003 – 0,587.t
t = 2,857 jam
Untuk mencapai konsentrasi di bawah 20 µg/ml, diperlukan waktu di atas 2,857 jam.
Jawaban :
DOSIS 50 mg
b) k = ln C2-ln C1
t2-t1
= ln 1,4 – ln 2,0
0,5 – 0,25
= 0,336 – 0,693
0,25
= – 1,426/jam
c) ln Ct = ln Co – k.t
ln 1,4 = ln Co – 1,428.0,5
0,336 = ln Co – 0,714
ln Co = 1,05
Co = 2,857 µg/ml
d) Vd = Dosis i.v
Co
= 50 mg
2,857 mg/L
= 17,5008 L
e) Grafik terlampir
f) ln Ct = ln Co – k.t
ln 0,225 = ln Co – 1,428.2,5
-1,491 = ln Co – 3,57
ln Co = 2,079
Co = 7,996 µg/ml
Vd = Dosis i.v
Co
17,5008 L = Dosis i.v
7,996 mg/L
Dosis i.v = 139,936 mg
DOSIS 100 mg
b) k = ln C2-ln C1
t2-t1
= ln 2,6 – ln 3,6
0,5 – 0,25
= 0,955 – 1,280
0,25
= 1,3016/jam
c) ln Ct = ln Co – k.t
ln 1,8 = ln Co – 1,3016.0,75
0,587 = ln Co – 0,9762
Co = 4,77 µg/ml
d) Vd = Dosis i.v
Co
= 100 mg
4,77 mg/L
= 20,96 L
e) Grafik terlampir
f) ln Ct = ln Co – k.t
ln C2,5 = ln Co – 1,3016.2,5
ln 0,225 = ln Co – 3,254
-1,491 = ln Co – 3,254
Co = 5,826 µg/ml
Vd = Dosis i.v
Co
17,5008 L = Dosis i.v
5,826 mg/L
Dosis i.v = 101,959 mg
LAMPIRAN GRAFIK
Lampiran 1
Lampiran 2