Lymphatic System and Immunity
Objectives
1. Describe the functions of the
lymphatic system.
2. Explain how lymph is formed.
3. Describe how lymph is
transported.
4. Describe the structure and
function of tonsils, lymph
nodes, the spleen, and the
thymus.
5. Define the concepts of
specificity and memory as
they apply to immunity.
6. Define innate immunity, and
describe the cells and
chemical mediators involved.
7. List the events of an
inflammatory response, and
explain their significance.
8. Define antigen.
9. Describe the origin,
development, activation, and
proliferation of lymphocytes.
10. Define antibody-mediated
immunity and cell-mediated
immunity, and name the cells
responsible for each.
11. Diagram the structure of an
antibody, and describe the
effects produced by
antibodies.
12. Discuss the primary and
secondary responses to an
antigen. Explain the basis for
long-lasting immunity.
13. Describe the functions of T
cells.
14. Explain the four ways that
adaptive immunity can be
acquired.
15. Explain how innate, antibody-
mediated, and cell-mediated
immunity can function
together to eliminate an
antigen.
16. Describe how aging affects
Topic Content
I. Functions of Lymphatic System
1. Fluid Balance
2. Lipid Absorption
3. Defense against foreign substances and
pathogens
II. Anatomy of Lymphatic System
Structure and Functions
1. Lymph
2. Lymphocytes
3. Lymphatic vessels
3.1 Lymphatic trunk
 Jugular trunk
 Subclavian trunk
 Bronchomediastinal
 Intestinal trunk
 Lumbar trunk
3.2 Right Lymphatic duct
3.3 Thoracic duct
3.4 Flow of the Lymph
 Blood capillaries (blood)
 interstitial spaces (interstitial fluid)
 lymphatic capillaries (lymph)
 lymphatic vessels (lymph)
 lymphatic trunk (lymph)
 lymphatic duct (lymph)
 junction of internal jugular and
subclavian veins (blood)
4. Lymph nodes
4.1 Lymphatic nodules
5. Tonsils
6. Spleen
7. Thymus
III. Overview of Lymphatic System
1. B cells
2. T cells
IV. Immunity
 Specificity
 Memory
V. Innate Immunity
1. Physical Barrier
2. Chemical Barriers
3. White Blood Cells
4. Inflammatory Response
4.1 Local Inflammation
4.2 Systemic Inflammation
 the lymphatic system and VI. Adaptive Immunity
immunity. 1. Antibody-mediated immunity
1.1 Antibodies
 IgG
 IgA
 IgM
 IgE
 IgD
1.2 Self-Antigens
2. Cell mediated immunity
2.1 Memory T cells
VII. Acquired Immunity
1. Active Natural Immunity
2. Active Artificial immunity
3. Passive Natural Immunity
4. Passive Artificial immunity
VIII. Effects of Aging on the Lymphatic System and Immunity

References:

Tate, P. (2011). Principles of Anatomy and Physiology 2nd Edition. McGraw-Hill Education, NY.

Tortora, G., (2016). Principles of Anatomy & Physiology 1st Asia-Pacific Edition. John Wiley & Sons, Ltd.

VanPutte, C., Regan, J., Russo, A. (2016). Seeley’s Essentials of Anatomy & Physiology 9th Edition,
Chapter 1-3. McGraw-Hill Education, NY.