Contract Services

Cayman Contract Services provides discovery and pre-clinical development services

to the global pharmaceutical, biotechnology, and academic research markets. Our
diverse suite of services leverages a team of over 150 highly skilled scientists with
expertise in medicinal chemistry, structure-based drug design, complex multi-step
organic synthesis, analytical chemistry, sample analysis and custom assay development.
We offer a personalized, flexible approach that enables our clients to accelerate their
drug discovery and development through a single-source partner, from novel drug
design and synthesis to target identification and validation.

Bioanalysis & Assay Development

Sample Analysis Custom Assay Development
·· Biomarker profiling ·· Immunoassays
·· Activity screening ·· Mass spectrometry-based assays
·· Lipidomic profiling ·· Enzyme activity assays
·· Immunopeptidome profiling ·· Cell-based assays
·· Proteomic profiling and PTM analysis ·· Reporter assays
·· Mitochondrial/bioenergetics profiling

Medicinal Chemistry & Structure-Based Drug Design

Drug Design, SAR and Process Scaling Structural Biology Core
·· In silico drug design and selectivity assessment ·· Recombinant protein production
·· Parallel library generation and characterization
·· Structure-activity relationship studies ·· Biophysical characterization
·· Lead optimization and development and optimization
·· Route development and scale-up ·· Protein crystallization
·· Pre-GMP process development ·· Structure determination by X-ray crystallography
·· In silico docking and homology modeling

Analytical Chemistry Chemical Synthesis

Qualitative & Quantitative Analysis Multi-Step, Complex Organic Synthesis
·· HPLC, LC-MS, GC-MS, NMR, and ·· Process scale-up (mg to 0.5 kg)
Karl Fischer testing ·· Stable isotopic labeling
·· Solubility, metabolism, rate of release, and ·· Conjugation chemistry
pharmacokinetics testing
·· Deformulation for active ingredient, impurity
limit, and stability testing

2018 CAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897 WWW.CAYMANCHEM.COM
 Our Contract Services Division provides expertise in:

MEDICINAL
BIOANALYSIS CHEMISTRY
& & CHEMICAL ANALYTICAL
ASSAY DEVELOPMENT STRUCTURE-BASED SYNTHESIS CHEMISTRY
DRUG DESIGN

Why Cayman?
We offer comprehensive solutions to drive your projects to completion. With prompt quotations, competitive
prices, quality science, and personalized customer service, our team is committed to our mission to help
make research possible.
·· Maintain complete control of your study with phase-based projects and the flexibility to pivot direction as
projects evolve.
·· Consult with our cross-functional team of scientists with diverse expertise and technical skill sets.
·· Access our state-of-the-art laboratories with dedicated resources to support your project needs.

Contact Us
Email us at contractresearch@caymanchem.com
Visit us online at www.caymanchem.com/services
Call us toll free at (888) 526-5351

2018 CAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897 WWW.CAYMANCHEM.COM