List of Antidotes

Antidotes to Common Medications

No. Drugs Antidote

01
Acetaminophen N-Acetylcysteine or Mucomyst

02
Anticholinesterase Atropine or Pralidoxime

03
Anticholinergics, diphenhydramine,
dimenhydrinate Physostigmine

04
Antifreeze Fomepizole, Ethanol

05
BenzodiazepinesZaleplonZolpidem Flumazenil (Romazicon)

Beta-Blocking agents, Calcium

06
channel blockers, Hypoglycemia,
Hypoglycemic agents Glucagon, Epinephrine

07
Calcium Channel Blockers Calcium Chloride, Glucagon

08
Coumadin Phytonadione or Vitamin K

09
Amyl nitrite, sodium nitrite, sodium
Cyanide thiosulfate

10
Cyclophosphamide Mesna

11
Digoxin Digibind or Digoxin Immune Fab

13
Heroin Naloxone (Narcan) or Nalmefene

14
Iron Deferoxamine
15
Heparin Protamine Sulfate

16
Lead EDTA, dimercaprol, succimer

18
Methotrexate Leucovorin calcium

19
Potassium Insulin + Glucose, Kayexalate

20
Methanol Folic acid

21
Valproic acid L-Carnitine

22
Sulfonylureas Octreotide (Sandostatin )

23
Isoniazid, ethylene glycol Pyridoxine HCl (Vitamin B6)

24
Sodium channel blockers (e.g. cyclic
antidepressants), salicylates Sodium Bicarbonate

25
Ethylene glycol Thiamine

Calcium channel blockersFluoride

salts (e.g., NaF)Hydrofluoric acid
26
(HF)Hyperkalemia (not digoxin- Calcium chloride andCalcium
induced)Hypermagnesemia gluconate

27
Ethylene glycolMethanol Ethanol

Alpha agonists (e.g., clonidine),

Opioids (e.g., codeine, diphenoxylate,
28
fentanyl, heroin, meperidine,
morphine and propoxyphene) Naloxone

29
Arsenic, Copper, Lead, Mercury D-Penicillamine (Cuprimine )
 Local anesthetics and possibly
othercardiac toxins (e.g., bupropion,
calciumchannel blockers, cocaine,
30
beta blockers, tricyclic Fat emulsion (Intralipid , Liposyn II ,
antidepressants) Liposyn III )