Male Reproductive

System

Evy Sulistyoningrum
 Male Reproductive system
• Testes
• Genital ducts
– Intratesticular
– Extratesticular
• Penis → dual funcons
• Associated glands → produce semen
– Seminal vesicles
– Prostate glands
– Bulbourethral glands of Cowperi
Male reproductive system
 Testes
• Oval organ, 4 x 2 x 3 cm3
• Descend from abdominal wall to scrotum →
“peritoneum → tunica vaginalis”, parally
surrounds anterolateral testis
• Scrotum
• Male gametes formation
• Synthesis, storage, release of testosteron
• Semen excretion
 General structure
• 3 layers
– Tunica vaginalis
– Tunica albuginea
• Mediastinum testis (corpus of Highmory), posterior
thickening, radiate to form septa → lobuli tess
– Tunica vasculosa
• Loose connective tissue + blood vessels
• Interstitial cells of Leydig
– Testosteron
– Eosinophyilic cytoplasm
Testis

Human, 10% formalin, H. & E., 3.4 x.

 Tubulus seminiferus

Monkey, Photomicrograph HE staining

 Tubulus seminiferus
• Highly convoluted hollow tubules
• Each lobule: 1-4 seminiferous tubules
• Ǿ 150-250 μm, 30-70 cm long
• 2 testes: 1000 tubules; 0,5 km
• Seminiferous epithelium (germinal epithelium)
– Stratified cuboid epithelium
– 2 kind of cells: Sertolli cells, germ cells
 Sertolli cells
• Sustentacular cells
• Tall columnair cells
• Basally located, clear, oval nucleus
• Zonnula occludens/tight junction at lateral wall between
adjacent cells→ blood tess barrier → protects sperm
• Functions:
– Support developing germ cells
– Phagocytosis activity
– ABP production
– Hormone production:
• Antimullerian
• Inhibin
Tubulus seminiferus
 Germ cell
• 4-8 layers of epithel
• Active undergo proliferation and
differentiation
• Spermatogenesis
– Spermatocytogenesis
– Meiosis
– Spermiogenesis
• 200 million sprematozoa/day
 Spermatogenesis
• Spermatogonia (2n)
• Spermatosit primer (2n) Spermatocytogenesis
• Spermatosit sekunder
• Spermatid Meiosis
– Golgi phase
– Cap phase
– Acrosomal phase Spermiogenesis
– Maturation phase
• Spermatozoa
Tubulus seminiferus
Tubulus seminiferus
Spermiogenesis
 Genital ducts
• Intratesticular genital
ducts
– Tubuli rekti
– Rete testis
– Ductuli efferentes
• Extratesticular genital
ducts
– Epididymis
– Ductus (vas) defferens
– Ductus ejaculatorius
 Genital ducts
Duct Epithelial lining Supporting tissue
Tubuli recti Sertoli cell in proximal half Loose connective tissue
Simple cuboidal pithelium in distal

Rete testis Simple cuboidal pithelium Vascular connective tisssue

Ductuli Cuboidal epithelium alternating Thin loose connective tissue
efferentes with ciliated columnar cells surrounded by a thin layer of circularly
arranged smooth muscle cells

Epididymis Pseudostratified epithelium Thin loose connective tissue

composed of basal cell and surrounded by a layer of circularly
principal columnar cell with arranged smooth muscle cells
stereocilia

Ductus Stereociliated pseudostratified Loose fibroelastic connective tissue,

deferens columnar epithelium thick three layer smooth muscle cells

Ejaculaory Simple columnar epithelium Subepithelial connective tissue folded,

duct no smooth muscle
Rete testis
Ductuli efferentes
 Epididymis
• Highlt convoluted tubule, thin-walled
• Gradually loose its convolution to the distal part
• 3 regions : head, body and tail
• Pseudostratified columnair epithelium with
stereocilia:
– Basal cell: stem cell regerating principal cells
– Principal cell: resorb luminal fluid
• A layer of circularly smooth muscle cells: peristaltic
contraction conducts spermatozoa to the ductus
defferens
Ductus Epididimis & Ductuli Eferentes
 Epididimis

Sz

SM Ep
 Ductus (vas) defferens
• Thick-walled musculatur tube
• Irregular lumen
• Pseudostratified columnair epithelium with
stereocilia
• 3 muscle layer:
– Inner and outer longitudinal
– Middle circular
• Ampulla: dilated terminus continued to ejaculatory
duct → prostac urethra
Duktus Deferens
Vas defferens
Duktus defferens
L

Ep
LP

IL

MC

OL
 Accessory genital glands
• Vesicula seminalis
• Prostat
• Glandula
bulbourethral
Cowperi
 Vesicula seminalis
• Vesicula seminalis
– Highly coiled tubular
glands
– Mucosa:
Pseudostratified
columnair epithelium
– Secret: fructose
(70%), fibrinogen,
ascorbic acid

Folded Mucosa
Vesicula Seminalis
 Vesikula Seminalis

Folded Mucosa
 Prostat
• Biggest gland
• Capsule
• 30-50 compound
tubuloalveolar gland → 3
concentric layers:
– Mucosal
– Submucosal
– Main
• Each layer → duct → prostac
urethra
• Pseudostratified columnar
epithelium
Prostate gland
Prostate gland Stroma fibromuskular

Alveoli kel. prostat

Muskular polos
Masuk ke dlm lipatan
mukosa

Konkremen di dlm
Lumen alveoli
kel. prostat

Lipatan2 epitel
mukosa
 Penis
• 3 columns of erectile tissue
– Corpora cavernosa (2): dorsal
– Corpus spongiosum: ventral; ended as glans penis
– Tip of the glans: end of urethra
• 3 corpora:
– surrounded by loose connective tissue sheath
– Contain numerous spaces lined by endothel
• Proximal skin: pubic hair, sweat and sebaceous glands
• Distal skin: hairless, less sweat glands
• Prepuce: mucous membrane, stratified squamous
nonkeratinized epithelium
Penis
Penis
A. Dorsalis penis
epidermis

Korpus kavernosum
dermis
Septum mediana
T. dartos A. Sentralis (profunda)

Ruang2 dlm korpus kavernosa

(vena2 kavernosa)
Fascia penis Vena superfisial
profunda
trabekula
T. Albugenia korpus Uretra pars kavernosa
kavernosum
T. Albugenia korpus Korpus spongiosum
spongiosum

Kel. Sebacea dlm dermis

Erection
• Which part of the male reproductive organ is
manipulated in:
– Vasectomy?
– Circumcision?
– Castration ?