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Scand J Pain 2018; aop

Clinical pain research

Manasi M. Mittinty*, Simon Vanlint, Nigel Stocks, Murthy N. Mittinty and G. Lorimer Moseley

Exploring effect of pain education on chronic


pain patients’ expectation of recovery and pain
intensity
https://doi.org/10.1515/sjpain-2018-0023 Conclusions: The results suggest that individuals who
Received January 24, 2018; revised February 18, 2018; accepted observed changes to pain cognition and self-management
­February 24, 2018 on receiving pain education reported lower pain intensity
Abstract and higher expectations of recovery than their counter-
parts who did not perceive any changes to pain cognition
Background and aims: Chronic pain affects an estimated and self-management.
1 in 10 adults globally regardless of age, gender, ethnic- Implications: Pain intensity and expectations about
ity, income or geography. Chronic pain, a multifactorial recovery are primary considerations for people in pain.
problem requires multiple interventions. One intervention What influences these factors is not fully understood, but
which demonstrates promising results to patient reported education about pain is potentially important. The results
outcomes is pain education. However, patient perspective suggest that individuals who observed changes to pain
on pain education and its impact remains fairly unknown. cognition and self-management on receiving pain educa-
A cross-sectional study involving individuals with chronic tion reported lower pain intensity and higher expectations
pain examined their perspectives on pain education; did of recovery than their counterparts who did not perceive
it change their understanding about their pain and self- any changes to pain cognition and self-management. The
management and did it have any impact on their perceived results from this study highlight the importance of effec-
pain intensity and recovery. tive pain education focused on reconceptualization of
Methods: The study complied with CHERRIES guide- pain and its management.
lines and the protocol was locked prior to data collection.
Keywords: chronic pain; pain education; pain cogni-
Primary outcomes were pain intensity and participants’
tion; self-management of pain; pain intensity; perceived
expectation of recovery. Univariate and multiple logistic
recovery.
regressions were used to analyze the data.
Results: Five hundred and seventy three people partici-
pated; full data sets were available for 465. Participants
who observed changes in their pain cognition and self- 1 Introduction
management following pain education reported lower
pain intensity and greater expectation of recovery than Persistent pain is a major global health problem [1], ranked
participants who did not observe changes to cognition as one of the leading causes for medical visits [2–4].
and management. Defined as pain on most days for more than 3 months [5],
persistent pain affects people regardless of age, gender,
ethnicity, income or geography. Present understanding of
pain stipulates that it is a complex, multi-factorial condi-
*Corresponding author: Manasi M. Mittinty, Indigenous Oral Health
Unit, The University of Adelaide, Level 4, AHMS Building, 57 North tion usually triggered by tissue injury. However, nocicep-
Terrace, Adelaide, SA 5006, Australia, Phone: +61 08 8313 1360, tion – the detection and transmission of a rapid change in
E-mail: manasi.mittinty@adelaide.edu.au tissue state – is neither sufficient nor necessary for pain
Simon Vanlint and Nigel Stocks: Discipline of General Practice, The [6]. Contemporary concepts emphasize biopsychosocial
University of Adelaide, Adelaide, SA, Australia
principles [6] for better understanding, assessment, pre-
Murthy N. Mittinty: School of Public Health, University of Adelaide,
Adelaide, SA, Australia
vention and management of persistent pain.
G. Lorimer Moseley: Sansom Institute for Health Research, Progress in our understanding of pain has led to a fun-
University of South Australia, Adelaide, SA, Australia damental shift in management approaches. Pain biology

© 2018 Scandinavian Association for the Study of Pain. Published by Walter de Gruyter GmbH, Berlin/Boston. All rights reserved.
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2      Mittinty et al.: Exploring effect of pain education on chronic pain patients’ expectation of recovery

education which emerged about 15 years ago [7] is now rec- participants’ daily pain management strategies, their
ognized as part of best practice [8]. Pain education aims expectation of recovery and their perspectives on the
to give patients an overview of the underlying physiologi- value of pain education, if they had received it. All partici-
cal mechanisms and adaptive processes which support pants provided digital consent prior to prior to participat-
persistent pain, such that pain becomes ‘over-protective’ ing in the survey. The study was approved by the Human
[9, 10]. Reconceptualization of pain in this fashion shows Research Ethics Committees of the University of Adelaide
clinically important improvements [11] with increased par- and the University of South Australia.
ticipation from patients in active biopsychosocial based All participants were individuals who could read and
rehabilitation [12]. Explaining pain seems to have similar understand English, were aged 18 years and above, and at
positive effects across painful conditions, for example the time of participation, had experienced pain on most
fibromyalgia [13, 14], neck pain [15], chronic fatigue syn- days for more than three consecutive months. There was
drome [16], and chronic low back pain [17, 18]. no limitation on gender, ethnicity or country of residence.
However, one issue that remains to be investigated is
the patients’ perspective on the impact of pain education.
Although empirical data shows that learning about pain 2.2 Measures
biology improves pain and enhances the likelihood of
recovery from persistent pain [12], whether or not patients 2.2.1 Dependent variables
see value in pain education, and whether or not perceiv-
ing that value is associated with pain and expectations of The primary outcomes used in this study were; patient-
recovery, remains unknown. It is an important question perceived pain intensity and patient-perceived time to
because it is the patient’s perspective that will best inform recovery. Information on pain intensity was collected from
their future responses to painful events and the advice the participants using the question, “what is the average
they give to others – an important method of knowledge severity of your pain in the last 2  days?” Participants
transfer [19]. were asked to complete a numerical rating scale (NRS),
The current study investigated these issues using an anchored at left with “0 – no pain” and at right with “10
online cross-sectional design. We aimed to determine if – worst pain”. Participants were also asked, “how long do
participants believed that pain education had changed you think it will take for you to recover from your current
their views on their pain (hereafter referred to as pain cog- pain problem?” where recovery was outlined as reduction
nition) and had changed the way they managed their pain in pain severity and improved daily functioning. The pos-
(hereafter referred to as self-management of pain), and sible responses were “3–6 months”, “up to 1 year”, “more
whether or not these perceptions were associated with than 1 year” and “never”. In order to fulfill the require-
their expectations of recovery and their current usual pain ments of logistic regression, and because we were primar-
intensity. ily interested in whether perspectives on the impact of
pain education would be associated with expecting recov-
ery rather than not expecting recovery, we analyzed recov-

2 Methods ery as a dichotomous variable: those who responded with


“never” and those who chose one of the other responses.
Similarly, we dichotomized pain intensity over the last
2.1 D
 esign and participants 2 days either side of the predicted median: ≤5 and ≥6. The
survey only allowed selection of whole numbers.
A cross sectional online survey design was used to collect
data on two critical aspects of chronic pain, use of supple-
ment intake [20] and pain education. The survey question- 2.2.2 Independent variables
naire was developed according to a review of the literature
and was built in accordance with the Checklist for Report- The independent/explanatory variables were: observed
ing Results of Internet E-Surveys (CHERRIES) [21]. The change in views on their pain (referred to as pain cog-
study protocol and questionnaire was published in The nition) following pain education, observed change in
Journal of Pain Research [22], prior to data collection. Con- self-management of pain following pain education, and
sistent with guidelines for transparency in research [23], demographic characteristics determined a priori to be
any deviations from the published protocol are noted. In likely confounders: age, gender, education level, employ-
addition to demographic data, the survey investigated ment status, and marital status.

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Pain education was defined as, information patients likelihood ratio test was used to find the best predictors
had received from their health care providers explaining of these relations. To compare the regression models and
their pain and potential triggers such as lack of sleep, maintain uniformity of sample size, “not applicable”
inactivity, stress which may aggravate their pain and cases from all the covariates were removed. If change in
symptoms. Participants were asked if they had received pain cognition and change in self-management demon-
pain education. If the response to this question was “yes”, strated collinearity, then separate regressions were under-
they were directed to these questions – “Did this educa- taken, as per protocol.
tion change the way you think about your pain?” and “Did Basic univariate descriptive statistics was used to
this education change the way you manage your pain?” characterize the sample for the proportion of the entire
Responses to both these questions were collected using cohort who had received pain education, those who had
simple “yes”, “no” dichotomization. observed change in pain cognition and change in self-
management of pain as a result of pain education, pain
intensity and expected recovery. Cross-tabulation was
2.3 D
 ata collection and analysis used to describe pain intensity and expected recovery
in groups that were defined by age, gender, education
Univariate and multiple logistic regression was computed level, employment status, marital status, pain edu-
to estimate the odds of expected recovery among patients cation, change in pain cognition and change in self-
who had reported observed change in pain cognition and management of pain. All analysis was performed in
self-management of pain following pain education. The STATA.14.1.

Table 1: Patient-reported pain intensity by participants aged 18 years and above.

Variable   Age 18–40 years   Total   Age 41 + years   Total


   
Pain intensity ≥6   Pain intensity ≤5 Pain intensity ≥6   Pain intensity ≤5
   
   
No   % No   % No   % No   %

Sexa

 Female   100   59   70   41   170   149   64   84   36   233


 Male   12   46   14   54   26   18   51   17   49   35
Education levela
 Primary   26   60   17   40   43   32   64   18   36   50
 Others   86   56   67   44   153   134   62   83   38   217
Employment statusa
 Full time employed   36   58   26   42   62   47   64   27   36   74
 Unemployed/on   37   82   8   18   45   58   72   23   28   81
leave because of pain
 Part time employed   15   39   23   61   38   27   49   28   51   55
 Home duties   5   63   3   38   8   22   58   16   42   38
 Student   17   43   23   58   40   7   54   6   46   13
Marital statusa
 Married   34   52   31   48   65   88   58   63   42   151
 Single/unmarried   47   63   28   37   75   56   69   25   31   81
 Partnered   31   56   24   44   55   21   64   12   36   33
Pain education
 No   9   47   10   53   19   24   71   10   29   34
 Yes   103   58   74   42   177   144   61   91   39   235
Duration of pain
 <1 year   7   50   7   50   14   8   42   11   58   19
 >1 year   105   58   77   42   182   160   64   90   36   250
Change in self-management of pain
 No   41   56   32   44   73   84   74   29   26   113
 Yes   71   58   52   42   123   84   54   72   46   156
Change in pain cognition
 No   46   59   32   41   78   72   72   28   28   100
 Yes   66   56   52   44   118   96   57   73   43   169

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Table 2a: Unadjusted and adjusted odds ratios for patient reported recovery among individuals who observed changes to pain cognition
following pain education.

  Patient-reported recovery (category “recovery”)



Unadjusted   Adjusted


OR (95% CI)   p-Value OR (95% CI)   p-Value

Age
 18–40 years   1     1  
 +41 years   0.66 (0.47–1.04)   0.08   0.65 (0.42–1.03)   0.06
Gender
 Female   1     1  
 Male   2.04 (1.21–3.66)   0.00   2.04 (1.15–3.62)   0.01
Marital status
 Single/unmarried   0.74 (0.47–1.16)   0.20   0.72 (0.44–1.16)   0.18
 Partnered   0.92 (0.54–1.56)   0.76   0.85 (0.48–1.51)   0.59
Education level
 Primary   1     1  
 Others   1.22 (0.73–2.03)   0.43   1.21 (0.71–2.05)   0.47
Employment status
 Full time employed   1     1  
 Unemployed/leave because of pain  0.99 (0.59–1.67)   0.99   0.99 (0.57–1.71)   0.99
 Part time employed   0.98 (0.56–1.74)   0.97   0.92 (0.51–1.66)   0.79
 Home duties   0.83 (0.39–1.73)   0.62   0.99 (0.45–2.17)   0.98
 Student   1.27 (0.65–2.48)   0.46   1.30 (0.65–2.61)   0.45
Change in pain cognition
 Yes   2.06 (1.34–3.16)   0.00   2.11 (1.35–3.29)   0.00

Table 2b: Unadjusted and adjusted odds ratios for patient reported recovery among individuals who observed changes to self-management
of pain following pain education.

  Patient-reported recovery (“recover”)



Unadjusted   Adjusted


OR (95% CI)   p-Value OR (95% CI)   p-Value

Age
 18–40 years   1     1  
 +41 years   0.70 (0.47–1.04)   0.08   0.69 (0.45–1.08)   0.10
Gender
 Female   1     1  
 Male   2.11 (1.21–3.66)   0.00   2.24 (1.26–3.99)   0.00
Marital status
 Single/unmarried   0.74 (0.47–1.16)   0.20   0.71 (0.44–1.15)   0.17
 Partnered   0.92 (0.54–1.56)   0.76   0.84 (0.47–1.48)   0.56
Education level
 Primary   1     1  
 Others   1.22 (0.73–2.03)   0.43   1.21 (0.71–2.05)   0.47
Employment status
 Full time employed   1     1  
 Unemployed/leave because of pain  0.99 (0.59–1.67)   0.99   1.05 (0.61–1.80)   0.85
 Part time employed   0.98 (0.56–1.74)   0.97   1.03 (0.57–1.84)   0.91
 Home duties   0.83 (0.39–1.73)   0.62   0.94 (0.43–2.06)   0.88
 Student   1.27 (0.65–2.48)   0.46   1.33 (0.66–2.67)   0.41
Change in self-management of pain
 Yes   2.06 (1.34–3.16)   0.00   2.00 (1.30–3.08)   0.00

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3 Results 3.1 Patient expected recovery

There were no deviations from the published protocol [22]. Table 2a shows the unadjusted and adjusted ORs obtained
Responses were received from 573 participants. Full data from univariate and multinomial logistic regression anal-
sets were available from 465, of which 412 participants ysis stratified into two age groups, including the best
(91%) had participated in pain education (Table 1), which predictors of expected recovery. Those who observed a
meant statistical comparison based on this variable was change in pain cognition as a result of pain education were
not possible. The mean (SD) pain intensity for the entire more likely to expect to recover than those who reported
cohort was 5.8 (2). Two hundred and eighty-seven of partic- no change in pain cognitions as a result (unadjusted
ipants reported that pain education had led to a change in OR = 2.06; 95% CI = 1.34–3.16). Males were more likely than
the way they think about their pain. Two hundred and sev- females to expect to recover (unadjusted OR = 2.04; 95%
enty-nine reported that pain education had led to a change CI = 1.21–3.66). Adjusted ORs were similar (Table 2a).
in the way they manage their pain. In the logistic/simple Ninety-seven percent (97%) of those who had partici-
linear regression, the effect estimates of the outcome con- pated in pain education reported observing a change in
founder relation were adjusted for age, gender, education their self-management strategies as a result. Those who
level, employment status and marital status. observed a change in self-management strategies were

Table 3: Patient-reported recovery according to age among participants with chronic pain aged 18 years and above.

Variable   Age 18–40 years   Total   Age 41 + years   Total


   
PRR (no)   PRR (yes) PPR (no)   PRR (yes)
   
   
No   % No   % No   % No   %

Sexa
 Female   110   65   60   35   170   170   73   63   27   233
 Male   14   54   12   46   26   18   51   17   49   35
Educationa
 Primary   25   58   18   42   43   41   82   9   18   50
 Others   99   65   54   35   153   147   68   70   32   217
Employment statusa
 Full time employed   44   71   18   29   62   47   64   27   36   74
 Unemployed/on leave because of pain  25   56   20   44   45   60   74   21   26   81
 Part time employed   21   55   17   45   38   41   75   14   25   54
 Home duties   6   75   2   25   8   26   68   12   32   38
 Student/unemployed   25   63   15   38   40   8   62   5   38   13
Marital statusa
 Married   39   60   26   40   65   100   66   51   34   151
 Single/unmarried   47   63   28   37   75   65   80   16   20   81
 Partnered   37   67   18   33   55   22   67   11   33   33
Pain education
 No   14   74   5   26   19   22   65   12   35   34
 Yes   110   62   67   38   177   167   71   68   29   235
Patient-provider relationship
 Not good   48   64   27   36   75   76   71   31   29   107
 Good   76   63   45   37    121   113   65   49   35   162
Duration of pain
 <1 year   4   29   10   71   14   2   11   17   89   19
 >1 year   120   66   62   34   182   187   75   63   25   250
Change in pain management
 No   54   74   19   26   73   86   76   27   24   113
 Yes   70   57   53   43   123   103   66   53   34   156
Change in pain cognition
 No   58   74   20   26   78   78   78   22   22   100
 Yes   66   56   52   44   118   111   66   58   34   169

Unknown category totals not shown based on ≤5 cases; PRR = patient-provider relationship.


a

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6      Mittinty et al.: Exploring effect of pain education on chronic pain patients’ expectation of recovery

more likely to expect to recover than those who did not pain and higher expectations of recovery than those who
observe a change (unadjusted OR = 2.06; 95% CI, 1.34– do not observe these shifts. Pain intensity and expected
3.16) (Table 2b). recovery are also affected by a range of demographic and
Table 3 shows a more comprehensive account of the other variables, but accounting for those variables in the
univariate logistic regression analysis stratified by age statistical model does not conceal the effect.
(18–40 years; 41 +  years). Younger participants were more Expectations about recovery are often investigated in
likely to expect recovery (~37% = 72/196) than older partic- acute or subacute pain populations [24, 25], and in pre-sur-
ipants (~30% = 80/269). Being married, or having attained gical groups [26, 27], but not in chronic pain patients. Our
a higher level of formal education, were associated with findings are consistent with available literature insofar as
expecting to recover. younger participants have higher expectations of recovery
than older ones. This may be because older people are
more likely to suffer from multiple chronic conditions [28]
3.2 P
 rimary outcome: current pain intensity and, arguably, may have lower self-efficacy when it comes
to exercise and movement-based rehabilitation. In addi-
Table 4a shows the unadjusted and adjusted ORs obtained tion, home duties affected changes in self-management
from univariate and multinomial logistic regression anal- of pain, which may also contribute to the male/female
ysis stratified into two age groups, including the best pre- differences.
dictors of perceived pain intensity. Subgroup analysis of It is notable that 40% of those who had participated
participants who observed change in pain cognition as in pain education reported that it did not change their
a result of pain education showed lower pain intensity pain cognition or self-management strategies. This rather
scores 5.7 (2) than those who reported no change. concerning failure rate might reflect, in part, patients
Individuals who reported observing a change in who already have a contemporary understanding of pain
self-management strategies as a result of pain education when they present for care, although the available data
(subgroup analysis) reported less pain intensity 5.6 (2) would suggest otherwise [11]. It might also be more likely
than/as those who reported no change. Adjusted OR for to reflect the lack of information on variables that can
participants who observed change in their pain cognition influence any educational intervention, for example the
as a result of pain education was 1.53 (95% CI, 1.01–2.33) message, the context and number of sessions, which were
(Table 4a). The adjusted association between pain inten- not collected.
sity and observed change in self-management of pain Of the confounding variables, we identified a priori
increased (adjusted OR, 1.69; CI, 1.12–2.56), suggesting that and entered into the statistical models, marital status,
participants who observed change in self-management of education level and employment status showed no asso-
pain following pain education were more likely to report ciation with “recovery”. This is in line with the literature,
less pain than participants who observed no change in which shows similar findings [29].
their self-management of pain. Pain intensity was also
affected by sex, age, duration of pain, employment status
especially home duties, which may be attributed to higher 4.1 Limitations
female participation. The full regression data shown in
Table 4b. This was a pragmatic study, in which data were col-
lected from individuals experiencing chronic pain in
the real-world, designed to answer specific questions;
4 Discussion we did not seek to fully characterize the subtle relation-
ships between different variables and we did not seek to
The aim of this study was to determine if participants determine the impact of other important variables – for
believed that pain education had changed their views example the number, type and context of education ses-
on their pain (pain cognition) and had changed the way sions, type of diagnosis, comorbidities and treatments
they self-managed their pain. We also wanted to deter- received. To investigate these issues would have required
mine whether or not these perceptions were associated a much larger sample and would have exerted a partici-
with their expectations of recovery and their perceived pant burden that pilot testing taught us would be unac-
pain intensity. Our main finding is that those who report a ceptable. Any online survey is associated with a lack of
shift in their pain cognition or self-management strategies control over who participates and how they participate.
after participating in pain education have lower perceived People self-select and we have no way of verifying the

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Mittinty et al.: Exploring effect of pain education on chronic pain patients’ expectation of recovery      7

Table 4a: Unadjusted and adjusted odds ratios for pain intensity among individuals who observed changes to pain cognition following pain
education.

  Pain intensity

Unadjusted   Adjusted


OR (95% CI)   p-Value OR (95% CI)   p-Value

Age
 18–40 years   1     1  
 +41 years   0.84 (0.57–1.23)   0.38   0.90 (0.58–1.38)   0.63
Gender
 Male   1.69 (0.98–2.92)   0.05   2.02 (1.12–3.61)   0.01
 Female   1     1  
Marital status
 Married   1     1  
 Single/unmarried   0.68 (0.44–1.05)   0.08   0.73 (0.46–1.17)   0.19
 Partnered   0.87 (0.52–1.44)   0.59   0.84 (0.48–1.46)   0.55
Education level
 Primary   1     1  
 Others   1.09 (0.67–1.76)   0.70   0.93 (0.56–1.55)   0.80
Employment status
 Full time employment   1     1  
 Unemployed/leave because of pain  0.50 (0.29–0.85)   0.01   0.47 (0.27–0.82)   0.00
 Part time employed   1.81 (1.06–3.11)   0.02   1.78 (1.02–3.10)   0.04
 Home duties   1.11 (0.56–2.21)   0.75   1.17 (0.56–2.41)   0.67
 Student   1.78 (0.93–3.40)   0.07   1.95 (0.99–3.81)   0.05
Change in pain cognition
 Yes   1.53 (1.03–2.27)   0.03   1.53 (1.01–2.33)   0.04

Table 4b: Unadjusted and adjusted odds ratios for pain intensity among individuals who observed changes to self-management of pain
following pain education.

  Pain intensity

Unadjusted   Adjusted


OR (95% CI)   p-Value OR (95% CI)   p-Value

Age
 18–40 years   1     1  
 +41 years   0.84 (0.57–1.23)   0.38   0.93 (0.60–1.43)   0.74
Gender
 Male   1.69 (0.98–2.92)   0.05   2.17 (1.21–3.89)   0.00
 Female   1     1  
Marital status
 Married   1     1  
 Single/unmarried   0.68 (0.44–1.05)   0.08   0.73 (0.45–1.16)   0.18
 Partnered   0.87 (0.52–1.44)   0.59   0.83 (0.48–1.45)   0.53
Education level
 Primary   1     1  
 Others   1.09 (0.67–1.76)   0.70   0.93 (0.55–1.55)   0.79
Employment status
 Full time employment   1     1  
 Unemployed/leave because of pain  0.50 (0.29–0.85)   0.01   0.48 (0.28–0.84)   0.01
 Part time employed   1.81 (1.06–3.11)   0.02   1.89 (1.09–3.28)   0.02
 Home duties   1.11 (0.56–2.21)   0.75   1.13 (0.54–2.34)   0.73
 Student   1.78 (0.93–3.40)   0.07   2.00 (1.02–3.92)   0.04
Change in self-management of pain
 Yes   1.53 (1.03–2.27)   0.03   1.69 (1.12–2.56)   0.01

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authenticity of responses, clarifying their responses, or taken into consideration for the analysis, it is for this
preventing individuals completing the survey twice on reason the results must be interpreted cautiously.
different devices. Our approach will also have excluded
potential participants who have no internet access. Our Acknowledgements: The authors would like to thank all
recruitment strategy depended on circulation of the the individuals who participated in our study and the
survey link via consumer organizations and clinician fol- organizations and societies who promoted our survey on
lowers of professional development websites. This means their websites.
that we would not have recruited those patients not Authors’ statements
involved with such organizations or with clinicians who Research funding: M. N. Mittinty is funded by John
are engaged with the professional development websites Lynch’s NHMRC Australian Fellow funding (ID 478115).
we used. Considering that many people with persistent G.  L. Moseley has received support from Pfizer, Kaiser
pain do not fully engage with the community, the reader Permanente, USA; Workers’ Compensation Boards in
must consider the limited extent to which our sample Australia, North America, and Europe; Agile Physi-
was representative of the persistent pain population. Our otherapy, USA; Results Physiotherapy, USA; the Interna-
design does not allow causal conclusions about effects of tional Olympic Committee and the Port Adelaide Football
one variable on another, nor the time course of effects. Club, Australia. G. L. Moseley is supported by a Princi-
The current study also had strengths. For example, our pal Research Fellowship from the National Health and
survey design was consistent with recommended proto- Medical Research Council of Australia.
cols; we published the full survey protocol prior to data Conflict of interest: G. L. Moseley receives royalties for
collection; we identified important potential confounders books on pain and rehabilitation, including two books
a priori and controlled for them in our analysis; we calcu- that are cited in this article. He receives speaker fees for
lated required sample size prior to commencement and lectures on pain and rehabilitation. All the authors declare
our sample exceeded the required sample size; the distri- that they have no conflict of interest.
bution of our independent and confounder variables was Informed consent: Informed consent was required and
broadly reflective of the wider population, reducing the collected digitally from all participants.
risk of selection bias on these variables. Ethical approval: The study was approved by the Human
Research Ethics Committee, The University of Adelaide,
and University of South Australia, Australia.
5 Conclusions
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