TD. Chula
He worked in secrecy
until 1929 when he
finally published On the
Electroencephalogram
of Man.
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EEG Soyrce :Brain Structure
white matter
thallamus
cerebellum
brainstem
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EEG
FREQUENCY AMPLITUDE
Beta > 13 Hz < 5 µV
n Alpha (8-13 Hz): occur in quiet, restful mental state, most intense
over the occipital region, especially when the eyes are closed.
n Beta (14-30 Hz): recorded from parietal and frontal regions, two
types:
n Beta I: disappear during intense mental activity leaving low
frequency wave.
n Beta II: occur during intense mental activity.
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EEG = Electroencephalograph
• The recording and analysis of electrical signal
generated by the brain
• The signals are small & in Noisy environments
• This involves 1) Good Equipments 2)
Meticulous recording techniques 3) Informed
interpretation of data
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The EEG Equipments : Classical
• Electrodes
• Head Box
• Channel selector
• Amplifiers
• Filters(HP,LP,Notch)
• Pen driver
• Paper/pen unit
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Electrical Basics : How big is EEG?
System Volts Amps
Lightning 100,000,000 10,000
Static Carpet 2,000 0.000001
Light Bulb 110 1
EKG 0.0015=1500uV 0.00001
EEG 0.00005=50uV 0.000001
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EEG : Small but distinctive
• Brain Signal presents
only locally at A while
cardiac & line noises,
though larger affect A &
B almost equally !
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Polarity Convention
• A common convention
in EEG is “Negative to
grid 1 makes the out
put deflects up”
• Grid 1 (ขัวต่ อที 1)
usually is active, G2
usually is reference
• Signals can actually
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In-phase Cancellation
Out-of-phase Summation
• Upward deflection =
Negative at G1 or
Positive at G2
• Wide Spread activity=>
Inphase=> no output
• Simultaneous signal of
opposite polarity
=>bigger output
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Filter: Choose what you want to see
• Four types: Low Freq.(HP),
High Freq.(LP),Band pass
& Band reject (Notch is
band rejects)
• Can be done by hardware
& software
• “Cutoff Freq” = where
1
f = ------------------------
2*Pi*RC power dec to a
Time Constant =R*C, @ 0.1 Sec = 1.6Hz predetermine value(~70%)
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Effect of filters:
Make unwanted waves smaller
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Effect of filter: 15 Hz can harm you!
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Filter Setting:
Write it down&Check the calibration
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What is “Normal” EEG?
• The EEG is
– Lack of abnormal patterns that is known to associated
with clinical disorders
– “Normal” EEG does not garuntee “normal brain” c/o not
all ab. Structire/funtion produce EEG abnormality
– “Abnormal” EEG can be seen in some normal individual
eg relative of Pt. with absence, ie, it does garuntee that
the person has “clinical” diseases.
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10-20 System Of Electrode
Placement
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The 10-20 system of EEG electrode placement
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Analyzing EEG Activities
• Morphology
• Distribution
• Frequency
• Voltage
• Duration
• State of the patient
• Background from which activity is arising from
• Similarity or dissimilarity to the other ongoing
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background rhythms
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EEG Interpretation
• Normal
– Lack of Abnormality
• Abnormal
– Non-epileptiform Patterns
– Epileptiform Patterns
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Photoparoxysmal Response
• Photic stimulation may elicit posterior dominant or generalized
epileptiform discharges in patients suspected of having
photosensitive seizure disorders
• Photo-paroxysmal response:
– complex waveform
– repeat at a frequency which is independent of the flash rate
– field extends beyond the usual posteriorly-situated photic
driving region and may be frontally dominant
– Time-locked with stimulus or not time-locked / self-sustained
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Photoparoxysmal Response
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Impedance testing
• Using AC 10-30 Hz
• Ohm’s Law
– V/I =R
• Higher Impedance =>
Higher Amplitude
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Reading EEG
• How is the EEG recorded ?
– What is the montage ?
– Sensitivity and speed
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EEG Montages
• Digital EEG usually
recoreded to a common
reference, then
reformatted to desired
montages for display
• Paper EEG is recorded
as is, tech. has to
selecet & monitor lives.
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EEG Montages
• Referential montage = G2
are conncted to a common
reference
• Bipolar montage = G2 of
the first Ch are connected
to the same el. as G1 of
the next ch
– Fp1-F7,F7-T3, T3-T5,
T5-O1
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Unipolar and Bipolar EEG measurement
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Artifacts
• Is the epileptiform activity real or an artifacts ?
– Artifacts do not have a field
– Artifacts have double phase reversal
– Artifacts can occurs from
• “Technical issue”
• “Elecectrical activity not generated by the brain”
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Artifact Sources
• Non-cerebral signals in the data
– Measured data is brain signal + artifacts
• Biological:
– EOG
• The eye is a dipole
• Movement visible in EEG
• Blinking
– EMG
• Voluntary muscle activity, especially close to head
(neck, tongue, face etc)
• ECG (Heart)
• Electronic
– Bad electrode signals
• Bad connections
• Poor resistances
– 50Hz Induction Noise(60Hz in US)
– Amplifier issues
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Electrooculogram (EOG)
+ cornea retina
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EEG Artifact 101:
Physiological artifacts
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EEG Artifact 101:
Non-physiological artifacts
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Digital EEG : technique & benefits
• All EEG done to a – Digital Filter
common reference – Voltage/Freq mapping
– Spike, seizure & event
• Analog=> digital detection
conversion at 200/sec, – Loop recording/Data
> 12 bits resolution reduction
• Benefit: – Time locked Video-EEG
– Reformating – Cheaper operating cost
– Smaller archive
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Computer techniques in EEG
• Amplitude mapping
• Coherence study
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Modern views of epilepsy
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Normal EEG
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Normal Adult EEG Patterns
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EEG Interpretation
• Normal
– Lack of Abnormality
• Abnormal
– Non-epileptiform Patterns
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– Epileptiform Patterns
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Alpha Rhythm
• The starting point of analysing awake EEG
• 8-13 Hz activity occurring during wakefulness
• 20-60 mV, max over posterior head regions
• Present when eyes closed; blocked by eye opening or alerting the patient
• 8 Hz is reached by 3 years of age and progressively increases in a
stepwise fashion until 9-12 Hz is reached by adolescence
• Very stable in an individual, rarely varying by more than 0.5 Hz.
• With drowsiness, alpha activity may decrease by 1-2 Hz
• A difference of greater than 1 Hz between the two hemispheres is
significant.
• 10% of adult have little or no alpha
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Normal Alpha Rhythm
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Normal Alpha Rhythm
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Normal Alpha Reactivity
Eyes Closed
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Normal Alpha Reactivity
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EEG of Drowsiness
(Stage I Sleep)
• In adults, most sensitive signs of drowsiness is the
disappearance of eye blinks and the onset of slow
eye movements
• Slowing, dropout or attenuation of the background
• Occurrence of theta activity over the posterior regions
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Drowsy
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Drowsy
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Drowsy
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Post Occipital Sharp
Transients of Sleep (POSTs)
• Sharp-contoured, mornophasic, surface-positive transients
• Occurring singly or in trains of 4-5 Hz over the occipital
head regions
• May have a similar appearance to the lambda waves during
the awake record but are of higher voltage and longer
duration
• Usually bilaterally synchronous but may be asymmetric over
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the two sides
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POSTs
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