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1. Hydrochlorothiazide- Block Na/Cl transporter in renal distal convoluted tubule.

4. Methyldopa – used primarily for hypertension during pregnancy.

5. Hydralazine- hydrazine derivative. Causes nitric oxide release.

7. Mecamylamine- A ganglion-blocking agent

8. Phenoxybenzamine- irreversibly blocks A1 and A2. Indirect baroreflex activation,

lowers BP.

9. Metyrosine- Blocks tyrosine hydroxylase. Reduces synthesis of dopamine,

norepinephrine and epinephrine. Lowers BP.

10. Furosemide- blocks na/k/2cl transporter in renal loop of henle

11. Nitroprusside- is a powerful parenterally administered vasodilator that is used in

treating hypertensive emergencies as well as severe heart failure. It is a complex of
iron, cyanide groups, and nitroso moiety.

12. Doxazosin- is efficacious in the treatment of hypertension and BPH. It has longer
half-life of about 22 hours.

13. Captopril- inhibit the converting enzyme peptidyl dipeptidase that hydrolyses
angiotensin i to angiotensin ii and inactivates bradykinin.

14. Phentolamine- a potent competitive antagonist at both alpha1 and alpha2

receptors.

15. Esmolol- is a b1-selective blocker that is rapidly metabolized via hydrolysis by red
blood cell esterases.

16. Terazosin- is a reversible alpha 1 selective antagonist that is effective in

hypertension and is also approved for use in men with urinary retension symptoms due
bph.

17. Labetalol- because of its combines alpha and beta blocking activity, it is useful in
treating the hypertension of pheochromocytoma and hypertensive emergencies.

18. Losartan- Block AT1 angiotensin receptors. Same as ACE inhibitors but no
increase in bradykinin.

30. Reserpine- blocks the ability of aminergic transmitter vesicles to take up and store
biogenic amines, by interfering with the vmat.
ACROSS

2. Prazosin- is a competitive piperazinyl quinazoline effective in the management of

hypertension.

3. Guanethedine- in high doses, it can produce profound sympathoplegia. It is too polar

to enter the central nervous system. As a result, this drug has none of the central effects
seen with many other antihypertensive agents. Interferes with amine release and
replaces norepinephrine in vesicles.

6. Verapamil- blocks both activated and inactivated L-type calcium channels. It can
cause peripheral vasodilation which may be beneficial on hypertension.

19. Clonidine- is lipid-soluble and rapidly enters the brain from the circulation. It
reduces blood pressure in the supine position and only rarely caused postural
hypotension.

20. Spironolactone- blocks aldosterone receptor in renal collecting tubule.

21. Propranolol- inhibits the stimulation of renin production by catecholamines.

22. Aliskerin- inhibits enyme activity of renin. Reduces angiotensin i and ii and
aldosterone.

23. Diazoxide- similar to thiazide diuretics but has no diuretic activity. It bound
extensively to serum albumin and vascular tissue.

24. Nebivolol- is a b1-selective blocker with vasodilating properties that are not
mediated by alpha blockade.

25. Enalapril- is an orl prodrug that is converted by hydrolysis to a converting enzyme

inhibitor with effects similar to those of captopril.

26. Fenoldopam- is a peripheral arteriolar dilator used for hypertensive emergencies

and postoperative hypertension. Acts primarily as agonist of dopamine d1 receptor.

27. Clevidipine- is a newer member of the calcium channel blockers that is formulated
for intravenous only.

28. Minoxidil- is a very efficacious orally vasodilator. Like hydralazine, it dilates

arterioles but not veins.

29. Metoprolol- is approximately equipotent to propranolol in inhibiting stimulation of B1

adrenoceptors but less potent than propranolol in inhibiting B2 receptors.
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1. Block Na/Cl transporter in renal distal convoluted tubule.

4. Used primarily for hypertension during pregnancy.

5. hydrazine derivative. Causes nitric oxide release.

7. A ganglion-blocking agent

8. irreversibly blocks A1 and A2. Indirect baroreflex activation, lowers BP.

9. Blocks tyrosine hydroxylase. Reduces synthesis of dopamine, norepinephrine and

epinephrine. Lowers BP.

10. Blocks na/k/2cl transporter in renal loop of henle

11. is a powerful parenterally administered vasodilator that is used in treating

hypertensive emergencies as well as severe heart failure. It is a complex of iron,
cyanide groups, and nitroso moiety.

12. is efficacious in the treatment of hypertension and BPH. It has longer half-life of
about 22 hours.

13. inhibit the converting enzyme peptidyl dipeptidase that hydrolyses angiotensin i to
angiotensin ii and inactivates bradykinin.

14. a potent competitive antagonist at both alpha1 and alpha2 receptors.

15. is a b1-selective blocker that is rapidly metabolized via hydrolysis by red blood cell
esterases.

16. is a reversible alpha 1 selective antagonist that is effective in hypertension and is

also approved for use in men with urinary retension symptoms due bph.

17. because of its combines alpha and beta blocking activity, it is useful in treating the
hypertension of pheochromocytoma and hypertensive emergencies.

18. Block AT1 angiotensin receptors. Same as ACE inhibitors but no increase in
bradykinin.

30. blocks the ability of aminergic transmitter vesicles to take up and store biogenic
amines, by interfering with the vmat.
ACROSS

2. is a competitive piperazinyl quinazoline effective in the management of hypertension.

3. high doses, it can produce profound sympathoplegia. It is too polar to enter the
central nervous system. As a result, this drug has none of the central effects seen with
many other antihypertensive agents. Interferes with amine release and replaces
norepinephrine in vesicles.

6. blocks both activated and inactivated L-type calcium channels. It can cause
peripheral vasodilation which may be beneficial on hypertension.

19. is lipid-soluble and rapidly enters the brain from the circulation. It reduces blood
pressure in the supine position and only rarely caused postural hypotension.

20. blocks aldosterone receptor in renal collecting tubule.

21. inhibits the stimulation of renin production by catecholamines.

22. inhibits enyme activity of renin. Reduces angiotensin i and ii and aldosterone.

23. similar to thiazide diuretics but has no diuretic activity. It bound extensively to
serum albumin and vascular tissue.

24. is a b1-selective blocker with vasodilating properties that are not mediated by
alpha blockade.

25. is an orl prodrug that is converted by hydrolysis to a converting enzyme inhibitor

with effects similar to those of captopril.

26. is a peripheral arteriolar dilator used for hypertensive emergencies and

postoperative hypertension. Acts primarily as agonist of dopamine d1 receptor.

27. is a newer member of the calcium channel blockers that is formulated for
intravenous only.

28. is a very efficacious orally vasodilator. Like hydralazine, it dilates arterioles but not
veins.

29. is approximately equipotent to propranolol in inhibiting stimulation of B1

adrenoceptors but less potent than propranolol in inhibiting B2 receptors.