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SCIENCE DEPARTMENT

A Journal developed by children for scientific research purposes

Number:______ K&U: _____I&D: _____P&E: _____ R: _____ Date:__________

TEACHER COMMENTS:

____________________________________________________________________________________

Acetylsalicylic Acid (Aspirin): Synthesis and Analysis


Laura Chaucanes, Fabián Villamil, Carlos Hugo Gualtero.

Problem Question: What would be the limiting factors for the synthesis of acetylsalicylic acid and what
effects can caused to the reaction?

Objectives:
- Perform the synthesis of acetylsalicylic acid.
- Learn, apply and calculate the percentage yield to the synthesis.
- Analyze the final product of the reaction from the acetylsalicylic acid.

Hypothesis: There are various limiting factors than can affect to the reaction, for example the
temperature or the concentration of the reactants, also, the state of the reactants physically and their
different dispersion and finally the presence of a catalyst.

Introduction:
Over time, many compounds have been obtained from nature and as an advantage it has been used to
cure ills or to produce an either good or bad effect in humans. These natural products are obtained from
biotic and abiotic factors. In addition, many transformations of these natural products and other
compounds has allowed to have a medical use. The German chemist Felix Hoffman, obtain a solid form
of acetylsalicylic acid, known as aspirin, in 1897. Aspirin is a derivative of salicylic acid which is a
mild, nonnarcotic analgesic useful in consolation of headache, muscle and joint aches. In this lab it will
be synthesize and analyze aspirin. In fact, there are more than one option to do the synthesize of the aspirin; but
here it will react, acetic anhydride with salicylic acid in existence of phosphoric acid, which is determine as a
catalyst.
Reaction equation:

(CH3CO)2O + HOC6H4COOH → CH3CO2C6H4CO2H + CH3COOH


Acetic anhydride salicylic acid acetylsalicylic acid acetic acid
SCIENCE DEPARTMENT
A Journal developed by children for scientific research purposes

Methods and materials:


- The methodology of investigation to address the research question taking into consideration the
significant factors that may relevance, reliability and sufficiency of the collected(Ej:
Independent, dependent and independent variables)
- The listed material including the brand, unit of measurement and uncertainty.
- A figure of the complete arrangement.
- The steps to develop the practice must be numbered or shown using a flow chart.
- Evidence of awareness of the significant safety, ethical or environmental issues that are relevant
to the methodology of investigation.(Ex: Showing the R&S security codes for chemical
reactants)
- Significant independent thinking, initiative and creativity.

Results:
- Relevant and sufficient quantitative and qualitative raw data (Ex: Images, pictures, tables,
graphs. Note: All these must have a title and be numbered) that could support a detailed and
valid conclusion to the research question.
- Appropriate data processing with the accuracy required to enable a conclusion to the research
question to be drawn consistent to the experimental data.
- Evidence of consideration of the impact of measuring uncertainty in the analysis.
- Interpretations of the processed data.

Conclusion:
- Comparison between the research question and the results supported in data presented.
- Comparison to the accepted scientific context. And extension of the investigation.
- Reflection about the limitations of the data sources of error and methodological issues.
- Suggestions for the improvement and extension of the investigation.

References:

- List of authors or books which supports the research. Those had to be highlighted along the
written article.

- Examples:
- [1] Bramwell, D., y Bramwell, Z. I. (1990). Flores silvestres de las islas Canarias. (3ª ed.)
Madrid: Rueda.
SCIENCE DEPARTMENT
A Journal developed by children for scientific research purposes

- [2] Sears, F. W., Zemansky, M. W., y Young, H. D. (1988). Física universitaria. Argentina:
Addison-Wesley Iberoamericana.
- [3] García Marí, F., Costa Comelles, J., y Ferragut Pérez, F. (1994). Las plagas agrícolas.( 2ª
ed.) Valencia: Phytoma España.

LABORATORY RUBRICS:

INQUIRING AND DESIGNING:


SCIENCE DEPARTMENT
A Journal developed by children for scientific research purposes

PROCESSING AND EVALUATING:


SCIENCE DEPARTMENT
A Journal developed by children for scientific research purposes
SCIENCE DEPARTMENT
A Journal developed by children for scientific research purposes

REFLECTING ON THE IMPACTS OF SCIENCE:


SCIENCE DEPARTMENT
A Journal developed by children for scientific research purposes

Reference:
IBO. International Baccalaureate Organization (UK) Ltd. Peterson House, Malthouse Avenue, Cardiff
Gate, 2014