1.

% TERDISOLUSI TABLET

TABLET INOVATOR

Mg Terdisolusi Setelah
C Mg Terdisolusi F. Koreksi Koreksi
T (ppm) (mg) (mg) (mg) % Disolusi
5 50 45 0 45,000 9,000
10 100 90 0,250 90,250 18,050
15 250 225 0,501 225,501 45,100
20 325 292,5 1,253 293,753 58,751
25 450 405 1,632 406,632 81,326
30 465 418,5 2,259 420,759 84,152
45 500 450 2,338 452,338 90,468
60 550 495 2,513 497,513 99,503
TABLET GENERIK A

Mg Terdisolusi Setelah
C Mg Terdisolusi F. Koreksi Koreksi
T (ppm) (mg) (mg) (mg) % Disolusi
5 45 40,5 0 40,500 8,100
10 90 81 0,225 81,225 16,245
15 210 189 0,451 189,451 37,890
20 310 279 1,053 280,053 56,011
25 435 391,5 1,556 393,056 78,611
30 450 405 2,184 407,184 81,437
45 490 441 2,262 443,262 88,652
60 530 477 2,463 479,463 95,893
TABLET GENERIK B

Mg Terdisolusi Ketelah
Mg Terdisolusi F. Koreksi Koreksi
T C (ppm) (mg) (mg) % Disolusi
5 46 41,4 0 41,400 8,280
10 85 76,5 0,230 76,730 15,346
15 220 198 0,426 198,426 39,685
20 320 288 1,102 289,102 57,820
25 430 387 1,606 388,606 77,721
30 445 400,5 2,159 402,659 80,532
45 495 445,5 2,237 447,737 89,547
60 540 486 2,487 488,487 97,697
 1. % TERDISOLUSI TABLET

TABLET INOVATOR

Mg Terdisolusi Setelah
C Mg Terdisolusi F. Koreksi Koreksi
T (ppm) (mg) (mg) (mg) % Disolusi
5 50 45 0 45,000 9,000
10 100 90 0,250 90,250 18,050
15 250 225 0,501 225,501 45,100
20 325 292,5 1,253 293,753 58,751
25 450 405 1,632 406,632 81,326
30 465 418,5 2,259 420,759 84,152
45 500 450 2,338 452,338 90,468
60 550 495 2,513 497,513 99,503
TABLET GENERIK A

Mg Terdisolusi Setelah
C Mg Terdisolusi F. Koreksi Koreksi
T (ppm) (mg) (mg) (mg) % Disolusi
5 45 40,5 0 40,500 8,100
10 90 81 0,225 81,225 16,245
15 210 189 0,451 189,451 37,890
20 310 279 1,053 280,053 56,011
25 435 391,5 1,556 393,056 78,611
30 450 405 2,184 407,184 81,437
45 490 441 2,262 443,262 88,652
60 530 477 2,463 479,463 95,893
TABLET GENERIK B

Mg Terdisolusi Ketelah
Mg Terdisolusi F. Koreksi Koreksi
T C (ppm) (mg) (mg) % Disolusi
5 46 41,4 0 41,400 8,280
10 85 76,5 0,230 76,730 15,346
15 220 198 0,426 198,426 39,685
20 320 288 1,102 289,102 57,820
25 430 387 1,606 388,606 77,721
30 445 400,5 2,159 402,659 80,532
45 495 445,5 2,237 447,737 89,547
60 540 486 2,487 488,487 97,697
 2. DATA SIMILARITAS TABLET INOVATOR DENGAN TABLET GENERIK A

DATA REFERENCE Harus

(+)
Timepoint % DISOLUSI Rt-Tt (Rt-Tt)^2 |Rt-Tt| n|Rt-Tt| nRt
5 9,000 0,900 0,810 0,900 6,300 63,000
10 18,050 1,805 3,258 1,805 12,635 126,350
15 45,100 7,210 51,984 7,210 50,470 315,700
20 58,751 2,740 7,508 2,740 19,180 411,257
25 81,326 2,715 7,371 2,715 19,005 569,282
30 84,152 2,715 7,371 2,715 19,005 589,064
45 90,468 1,816 3,298 1,816 12,712 633,276
60 99,503 3,610 13,032 3,610 25,270 696,521
∑ (n|Rt-
DATA TES ∑ (Rt-Tt)^2 94,632 Tt|) 164,577 ∑nRt 3404,450
1/n(Sampling : 7) 0,143 [∑ (n|Rt-Tt|)]/[∑nRt] 0,048
Timepoint %DISOLUSI (1/n) ∑ (Rt-Tt)^2 13,519 [∑ (n|Rt-Tt|)]/[∑nRt].100 4,834
5 8,100 1 + (1/n) ∑ (Rt-Tt)^2 14,519 f1
10 16,245 [1 + (1/n) ∑ (Rt-Tt)^2]^-0,5 0,262
15 37,890 {[1 + (1/n) ∑ (Rt-Tt)^2]^-0,5 . 100} 26,244
log {[1 + (1/n) ∑ (Rt-Tt)^2]^-0,5 .
20 56,011 100} 1,419
50 . log {[1 + (1/n) ∑ (Rt-Tt)^2]^-
25 78,611 0,5 . 100} 70,952
30 81,437 f2
45 88,652
60 95,893
3. GRAFIK DATA SIMILARITAS TABLET INOVATOR DENGAN TABLET GENERIK A

F1 = 5,14 F2 = 72,44
 4. DATA SIMILARITAS TABLET INOVATOR DENGAN TABLET GENERIK B

Harus
DATA REFERENCE (+)
(Rt-
Timepoint % DISOLUSI Rt-Tt Tt)^2 |Rt-Tt| n|Rt-Tt| nRt
5 9,000 0,720 0,518 0,720 5,040 63,000
10 18,050 2,704 7,312 2,704 18,928 126,350
15 45,100 5,415 29,322 5,415 37,905 315,700
20 58,751 0,931 0,867 0,931 6,517 411,257
25 81,326 3,605 12,996 3,605 25,235 569,282
30 84,152 3,620 13,104 3,620 25,340 589,064
45 90,468 0,921 0,848 0,921 6,447 633,276
60 99,503 1,806 3,262 1,806 12,642 696,521
∑ (n|Rt-
DATA TES ∑ (Rt-Tt)^2 68,229 Tt|) 138,054 ∑nRt 3404,450
1/n(Sampling : 5) 0,143 [∑ (n|Rt-Tt|)]/[∑nRt] 0,041
Timepoint % DISOLUSI (1/n) ∑ (Rt-Tt)^2 9,747 [∑ (n|Rt-Tt|)]/[∑nRt].100 4,055
5 8,280 1 + (1/n) ∑ (Rt-Tt)^2 10,747 f1
10 15,346 [1 + (1/n) ∑ (Rt-Tt)^2]^-0,5 0,305
15 39,685 {[1 + (1/n) ∑ (Rt-Tt)^2]^-0,5 . 100} 30,504
log {[1 + (1/n) ∑ (Rt-Tt)^2]^-0,5 .
20 57,820 100} 1,484
50 . log {[1 + (1/n) ∑ (Rt-Tt)^2]^-
25 77,721 0,5 . 100} 74,218
30 80,532 f2
45 89,547
60 97,697
5. GRAFIK DATA SIMILARITAS TABLET INOVATOR DENGAN TABLET GENERIK B

F1 = 4,63 F2 = 74,70
 TUGAS PRAKTIKUM BIOFARMASI

PERHITUNGAN % TERDISOLUSI TABLET DAN SIMILARITAS TABLET GENERIK DENGAN TABLET INOVATOR

Nama / NPM : Winny Anggraeni / A 131 036 Fuzy Fauziyah Yusuf / A 131 045

Ikrima Zahra Kamilah / A 131 054 Amelia Rahayu / A 131 064

Aurina Ligina / A 131 066 Eka Putri Wiyati / A 153 012

Aysa Gratia Febriana / A 131 014

Kelas / Kelompok : Reguler Pagi B / 7

LABORATORIUM BIOFARMASI

SEKOLAH TINGGI FARMASI INDONESIA

zat aktif : 500 mg

media disolusi : 900 ml

cuplikan yang di ambil : 5 ml

sampling (n) :7

Tabel konsentrasi rata-rata ZA terdisolusi

Waktu Konsentrasi ZA Konsentrasi ZA tablet Konsentrasi ZA tablet

tablet inovator (ppm) generik A (ppm) generik B (ppm)
5 50 45 46
10 100 90 85
15 250 210 220
20 325 310 320
25 450 435 430
30 465 450 445
45 500 490 495
60 550 530 540