for
B. Pharm. Course
(Structure of courses)
2013-14
Dr. H. S. Gour Central University, Sagar (MP)
Proposed Curriculum for B. Pharm. Course: w.e.f. Session 2013 - 2014
(Structure of courses)
Hints for Course Code : PHSC First Digit Second Digit Third Digit(s)
PHSC denotes Pharmaceutical Sciences, First Digit denotes Semester No.,
2nd Digit denotes Course Level 1 for UG and 2 for PG, Third digit(s) denotes paper No.
Dept. of
Department Pharmaceutical Course B.Pharm. Code
Sciences
Pharmaceutical Subject
Subject PHS-54 School EAT 50
Sciences Code
Course
Course Code Course Name P* Credits
SNo
01 PHSC 1108 Computer Applications 3 1
Pharmaceutical Chemistry I
02 PHSC 1109 3 1
(Inorganic Chemistry)
Pharmaceutical Chemistry II
03 PHSC 1110 3 1
(Organic Chemistry-I)
Introduction to
04 PHSC 1111 3 1
Pharmaceutics
##
05 PHSC 1112 Remedial Biology 3 1
Total= 12/15 4/5**
Note:* L - Lecture T – Tutorial P – Practical C- Total Credit
# Students have to appear in either PHSC 1106 or PHSC 1107 Course
## Course applicable to only those students who opt for PHSC 1107
** Total Credits in particular 4 for students who opt PHSC 1106 and credits 5 for students
who opt PHSC 1107.
Dr. H. S. Gour Central University Sagar (MP)
Proposed Curriculum for B. Pharm. Course
(Structure of courses)
Dept. of
Department Pharmaceutical Course B.Pharm. Code
Sciences
Pharmaceutical Subject
Subject PHS-54 School EAT 50
Sciences Code
Course
Course Code Course Name L* T* Credits
SNo
Applied Mathematics
01 PHSC 2101 4 0 4
and Biostatistics
Human Anatomy,
02 PHSC 2102 Physiology and Health 4 0 4
Education
Pharmaceutical
03 PHSC 2103 4 0 4
Engineering
Pharmaceutical
04 PHSC 2104 Chemistry III (Organic 3 0 3
Chemistry-II)
Pharmacognosy and
05 PHSC 2105 4 0 4
Phytochemistry-I
06 PHSC- 2110 Environmental Studies 3 0 3
Total 22 0 22
Course
Course Code Course Name P* Credits
SNo
Human Anatomy,
01 PHSC 2106 Physiology and Health 3 1
Education
Pharmaceutical
02 PHSC 2107 3 1
Engineering
Pharmaceutical
03 PHSC 2108 Chemistry III (Organic 3 1
Chemistry-II)
Pharmacognosy and
04 PHSC 2109 3 1
Phytochemistry-I
Total 12 04
Course Course
Course Name L* T* Credits
SNo Code
01 PHSC 3101 Physical Pharmaceutics 4 0 4
02 PHSC 3102 Cell and Molecular Biology 2 0 2
Pharmaceutical Chemistry
03 PHSC 3103 IV (Chemistry of Natural 4 0 4
Products)
Pharmaceutical
04 PHSC 3104 4 0 4
Microbiology
Pharmacognosy and
05 PHSC 3105 4 0 4
Phytochemistry- II
Total= 18 0 18
Course Course
Course Name P* Credits
SNo Code
01 PHSC 3106 Physical Pharmaceutics 3 1
Pharmaceutical Chemistry
02 PHSC 3107 IV (Chemistry of Natural 3 1
Products)
Pharmaceutical
03 PHSC 3108 3 1
Microbiology
Pharmacognosy and
04 PHSC 3109 3 1
Phytochemistry- II
Total 12 04
Course Course
Course Name L* T* Credits
S. No. Code
Human Physiology and
01 PHSC 4101 Pathophysiology of Common 4 0 4
Diseases
02 PHSC 4102 Dosage Form Design 4 0 4
Pharmaceutical
03 PHSC 4103 4 0 4
Biotechnology
04 PHSC 4104 Pharmaceutical Analysis I 4 0 4
Pharmacy Practice
05 PHSC 4105 (Dispensing and Community 4 0 4
Pharmacy)
Total 20 0 20
Course Course
Course Name P* Credits
S. No. Code
Human Physiology and
01 PHSC 4106 Pathophysiology of Common 3 1
Diseases
02 PHSC 4107 Dosage Form Design 3 1
Pharmaceutical
03 PHSC 4108 3 1
Biotechnology
04 PHSC 4109 Pharmaceutical Analysis I 3 1
Pharmacy Practice
05 PHSC 4110 (Dispensing and Community 3 1
Pharmacy)
Total 15 05
Course Course
Course Name L* T* Credits
S. No. Code
01 PHSC 5101 Cosmetic Technology 4 0 4
02 PHSC 5102 Biochemistry 4 0 4
03 PHSC 5103 Medicinal Chemistry I 3 0 3
04 PHSC 5104 Pharmacology I 3 0 3
Pharmacognosy and
05 PHSC 5105 3 0 3
Phytochemistry III
Total 17 0 17
Course Course
Course Name P* Credits
S. No Code
01 PHSC 5106 Cosmetic Technology 3 1
02 PHSC 5107 Biochemistry 6 2
03 PHSC 5108 Medicinal Chemistry I 3 1
04 PHSC 5109 Pharmacology I 3 1
Pharmacognosy and
05 PHSC 5110 3 1
Phytochemistry III
Total 18 6
Course Course
Course Name L* T* Credits
S. No Code
Pharmaceutical Industrial
01 PHSC 6101 3 0 3
Management
02 PHSC 6102 Pharmaceutical Analysis II 4 0 4
03 PHSC 6103 Medicinal Chemistry II 3 0 3
04 PHSC 6104 Pharmacology II 3 0 3
Pharmaceutical
05 PHSC 6105 4 0 4
Manufacturing Technology
Total= 17 0 17
Course Course
Course Name P* Credits
S. No Code
01 PHSC 6106 Pharmaceutical Analysis II 6 2
02 PHSC 6107 Medicinal Chemistry II 3 1
03 PHSC 6108 Pharmacology II 3 1
Pharmaceutical
04 PHSC 6109 6 2
Manufacturing Technology
05 PHSC 6110 Industrial Tour/Project 0 2
Total= 18 8
Course Course
Course Name L* T* Credits
S. No Code
01 PHSC 7101 Medicinal Chemistry III 3 0 3
02 PHSC 7102 Pharmaceutical Analysis III 4 0 4
03 PHSC 7103 Pharmacology III 3 0 3
Drug Legislation and
04 PHSC 7104 4 0 4
Regulatory Affairs
Clinical & Hospital
05 PHSC 7105 4 0 4
Pharmacy
Total= 18 0 18
Course Course
Course Name P* Credits
S. No Code
01 PHSC 7106 Medicinal Chemistry III 3 1
02 PHSC 7107 Pharmaceutical Analysis III 3 1
03 PHSC 7108 Pharmacology III 6 2
Clinical & Hospital
04 PHSC 7109 3 1
Pharmacy
Total= 15 5
Course Course
Course Name L* T* Credits
S. No Code
Novel and Controlled
01 PHSC 8101 4 0 4
Drug Delivery Systems
Biopharmaceutics &
02 PHSC 8102 4 0 4
Pharmacokinetics
Pharmacognosy and
03 PHSC 8103 3 0 3
Phytochemistry -IV
04 PHSE 8104 Elective 4 0 4
Total 15 0 15
Course Course
Course Name P* Credits
S. No Code
Novel and Controlled Drug
01 PHSC 8105 3 1
Delivery Systems
Biopharmaceutics &
02 PHSC 8106 3 1
Pharmacokinetics
Pharmacognosy and
03 PHSC 8107 3 1
Phytochemistry -IV
04 PHSC 8108 Project on elective 6 2
Total 15 05
Professional Communication
Theory: 2h/week
Unit – I ( 09 Hrs.):
English grammar- Parts of speech, articles, preposition, tenses, active and passive speech, direct and indirect
speech.
Presentation techniques- Tips, Dos and don’ts of presentation, notice and placard presentations.
Unit – II ( 09 Hrs.):
Written skills: Proposal, writing formats, report writing business letters, applications, covering letters, curriculum
vitae designing, summary writing.
Listening- Phonetics and pronunciations (with the help of phonetics dictionary and with tapes from language
laboratory).
Unit – III ( 09 Hrs.):
Etiquettes and grooming.
Group discussion and extempore communication.
Interviews- Tips and model interviews (video shooting and display).
Tutorial: 1h/week
Unit – IV ( 09 Hrs.):
English grammar- Parts of speech, articles, preposition, tenses, active and passive speech, direct and indirect
speech.
Unit – V ( 09 Hrs.):
Presentation techniques- Tips, Dos and don’ts of presentation, notice and placard presentations. (3)
Written skills: Proposal, writing formats, report writing business letters, applications, covering letters, curriculum
vitae designing, summary writing.
Books Recommended:
1. Wren and Martin, English Grammar.
2. Tapes from language laboratory, Hyderabad.
Course Code Course L T Credits
PHSC 1102 Computer Applications 2 0 2
Hours Per Week
Computer Applications
Theory: 2 h/week(Total 40 Hours)
Unit – I (06 Hrs):
Elements of Computer System: Development of Computers through generation, classification and applications.
Basic Schematic Diagram of Digital Computer, Functions of its various components (I/P, O/P, CPU, ALU, Memory),
Types of memory, concept of RAM, ROM and Virtual memory. Problem solving, algorithm, flowchart, SDLC, data
structure, list, stack, queue, DBMS.
Unit – II (06 Hrs):
Concept of System Software: Evolution of operating system, type and need of Translators, Compare MS-DOS vs.
UNIX, Elements of LINUX, Internal and External commands of MS-DOS. Advantages, limitation and features of
various Windows versions like Windows95/98/2000/XP/2003.
Unit – III (06 Hrs):
Application Software & packages: MS Office 2003: Features, advantages and limitations of its tools.
Word Processing (MS Word): Basic operation and tools of MS Word with special emphasis to Webpage conversion,
mail merge.
Spreadsheet (MS Excel): Elementary functions and tools of MS Excel with special emphasis using statistical and
analytical parameters.
Presentation (MS Power point): Slide preparation, insertion of template, file, tables, picture, chart, movies, sound
animation and other special effects.
Unit – IV (06 Hrs):
Computer Programming Languages: Features & Comparison of various types of computer languages -
machine/low level languages, high level, and assembly languages.
Understanding ‘C’ Languages: Features of C, data types, Character Set, Tokens, expressions, operations, Simple
programs using; getchar and putchas, exposure to scanf and printf, conditional statements (if else, switch and break
statements), loops (for, while, do while, continue statement), arrays, functions, Strings etc.
Unit – V (06 Hrs):
Internet & Computer Applications: Introduction to Computer Networks, Internet (browsing, www, URL, HTTP, FTP,
IP Address, E-Mail. Webpage designing). Computer applications in Pharmaceutical and clinical studies, Uses of
networking in Pharmaceutical Industries.
Books Recommended:
1. “Computers Today” by Senders D. H., McGrawHill.
2. “Computer fundamentals” by P. K. Sinha. Third edition, BPB Publication.
3. “Information technology”, Jaiswal, S., Galgotia Pub.
4. Manuals for MS DOS, MS Office, MS Windows, UNIX.
5. “Office 2000/2003 Complete”, BPB Publication.
6. “Internet basic reference A to Z”, by Falk B., BPB, Delhi
7. “Operating Systems” by Stallings,PHI.
8. “Computers in Pharmacy” by Thakur P.S.,Manchanda R.Nand P; Birla Pub.Pvt Ltd.
9. “Programming in ANSI-C by E. Balaguruswamy –Tata Mc. Graw Hill.
10. “Computer Networks” by Tenenbaum A.S., Prentice Hall of India.
11. “Programming with C” by Byron Gottfield.
Course Code Course L T Credits
Pharmaceutical Chemistry I
4 0 4
PHSC 1103 (Inorganic Chemistry)
Hours Per Week
Pharmaceutical Chemistry I (Inorganic Chemistry)
Theory: 4h/week:
Preservatives:
Pharmaceutical accepted glass-chemistry of glass, types of test employed for glass.
Waters: official water (water, purified water, water for injection, bacteriostatic water for injection, sterile water for
injection)
Unit –III (12 Hrs.):
Pharmaceutical aids and necessities
• Acids and bases-acid base theory ,specification of acidity and basicity, official inorganic acid(boric acid
HCl, HNO3, H3PO4), nonofficial inorganic acids(H2SO4), official inorganic bases(strong ammonia solution,
calcium hydroxide, KOH, Na2CO3,NaOH,soda lime)
• Buffers-theory and mechanism, pharmaceutical buffer selection, pharmaceutical buffer system
• Antioxidant-theory, the selection of antioxidants, official antioxidants (hypophosphorous acid, sodium
bisulphite, sodium thiosulphate, sodium nitrite, nitrogen).
Unit –IV (12 Hrs.):
Nuclear chemistry-nuclear composition ,forces and stability, isotope ,radioactive emission, measurement of
radioactivity, modes of decay, half life period, artificial radioactivity, application in pharmacy.
Radiopharmaceuticals and contrast media- Radiopharmaceuticals, Radiopharmaceuticals preparation and radio
opaque contrast media., Diagnostic drugs.
Unit –V (12 Hrs.)
Co-ordination compounds and comlexation-theoratical consideration and official products(calcium diacetate
edetate, disodium edetate, dimercaprol, and penicillamine).
Pharmaceutical necessities –preservatives.
Complexation and chelation -application in pharmacy
Books Recommended:
1. Block, J.H., Roche, E., Soine, T. and Wilson, C., “Inorganic, Medicinal and Pharmaceutical Chemistry”,
Lea and Febiger.
2. Discher, C.A. et al., Modern inorganic pharmaceutical chemistry, Waveland press.
3. Pharmacopoeia of India, 1996
4. Atherden, L.M., Bentley and Drivers “Text book of Pharmaceutical Chemistry” Oxford University press,
London.
Course Code Course L T Credits
Pharmaceutical Chemistry-II
4 0 4
PHSC 1104 (Organic Chemistry-I)
Hours Per Week
Relations of structure with properties like density, melting point, boiling point, solubility, etc.
Books Recommended:
1. Morrison, B.T., and Boyd, R.N., “Organic Chemistry”, Prentics Hall of India Pvt. Ltd., New Delhi.
2. Vogel A.I., “Textbook of Practical Organic chemistry”, ELBS/Longman.
3. Mann, F.G. and Saunders, B.C., “Practical Organic Chemistry”, ELBS/Longman
4. Finar, I.L. Organic Chemistry, Vol.-I and II, ELBS/Longman
5. Hendrikson, Organic Chemistry.
Course Code Course L T Credits
Introduction to
PHSC 1105 4 0 4
Pharmaceutics
Hours Per Week
Introduction to Pharmaceutics
Theory: 4h/week
Pharmaceutical calculations and posology: Pharmaceutical calculations, significant figures, different systems of
weights and measures; calculation of dosages for children; reducing and enlarging of formulae;; percentage
solutions; allegation; proof spirit; thermometry; isotonic solutions; electrolyte solutions; displacement value
Size Separation: Standard screens, oscillating tray sifter, grating sifters, cyclone separators. Sedimentation,
elutriation.
Extraction: Leaching process, factors affecting the efficiency of leaching process; diffusion batteries, continuous
diffusion batteries, Dorr agitator, continuous counter current extraction, Cragg's apparatus.
Books Recommended:
1. Ansel: Introduction to Pharmaceutical Dosages Forms
2. Remington's Pharmaceutical Sciences.
3. Indian Pharmacopeia.
4. British Pharmacopeia.
5. Jain & Sharma: The theory and practice of Professional Pharmacy
6. Jain : Pharmaceutical Arithmetic.
7. An introduction to Chemical Engineering - Badger and Banchero.
8. Chemical Engineering - Richardson and Coulson.
9. Introduction to Unit Operation - McCabe and Smith.
10. Theory and Practice of Industrial Pharmacy-Lachman,Lieberman and Kanig
11. Bentley's Text Book of Pharmaceutics - Rowlin.
Course Code Course L T Credits
PHSC 1106 Remedial Mathematics 2 2 4
Hours Per Week
Remedial Mathematics
Theory: 2h/week
Unit- I ( 12 Hrs):
Algebra: Laws of indices, Surds, pure and mixed Surds, Rationalization of surds, Equivalent fraction with a
rational denominator of a surd, Square root, Cube root of surds. Modulus and arguments of a complex number,
square root of a complex number. Solution of quadratic equations, theory of quadratic equations, solution of
simultaneous equations and miscellaneous equations. Logarithms, Properties of logarithms, Arithmetical
Geometrical and Hormonical progressions, permutation and combination.
Unit- II ( 12 Hrs):
Binomial theorem with positive index. Matrices, types of matrices, addition, subtraction, multiplication and
transpose of matrices, adjoint and inverse of a matrix. Application of matrices in solving equations. Determinants
and their properties, applications of determinants in the solution of linear equation.
Unit- III ( 12 Hrs):
Co-ordinate Geometry: Distance formula, area of a triangle and quadrilateral, Equations of a straight line, angle
between straight lines, point o intersection of two straight lines, perpendicular distance of a point from the straight
lines, Second degree equation representing two lines, Equation of circle.
Unit- IV ( 12 Hrs):
Trigonometry: Measurement of angles relation between trigonometric ratio of an angle of a right angle triangle,
complementary and supplementary angle, multiple and submultiple angles, product formulae sum and difference
formulae of trigonometric ratios, identities of trigonometric ratios, relation between sides and angles of any
triangle, area of a triangle, radius of circumscribed, inscribed circles.
Unit- V ( 12 Hrs):
Calculus: Limit of a function, limit at infinity, Differentiation of some function, product rule, quotient rile of
differentiation, differentiation of inverse trigonometric function, implicit function, logarithmic from, parametric form,
successive differentiation, tangent and normal, maxima and minima.
Integration as inverse of differentiation, simple integration formulae, integration by substitution and by parts.
Books Recommended:
1. Algebra by Hall and Knight
2. Coordinate geometry by S. L. Loney.
3. Trigonometry by S. L. Loney.
4. Differential Calculus by Gorakh Prasad.
5. Integral Calculus by Gorakh Prasad.
Course Code Course L T Credits
PHSC 1107 Remedial Biology 4 0 4
Hours Per Week
Remedial Biology
Theory: 4h/week
Unit-I (12 Hrs.):
Origin and evolution of life: an outline.
Classification and general treatment of Plant Kingdom.
Study of the following families of medicinal and aromatic plants- Apocynaceae, Solanaceae, Labiatae,
Papaveraceae, Umbelliferae, Leguminosae, Rubiaceae, Liliaceae and Scrofulariceae.
Unit-II (12 Hrs.):
Physiology of plants- photosynthesis, respiration and transpiration.
Fundamental laws of inheritance- Mendel’s law. Life cycle of a common angiosperm plant.
Unit-III (12 Hrs.):
Morphology, histology and structural organization of root, stem, bark, wood, leaf, flower, fruit and seed.
Classification and general treatment of animal kingdom.
Unit-IV (12 Hrs.):
Structure of plant cell, cell organelles, types of plant tissues and their functions.
Study of structure and life cycle of amoeba, plasmodium and diseases caused by systemic helminths and
parasites.
Unit-V(12 Hrs.):
General treatment of digestive, circulatory system and reproductive cycles of amphibian and mammals.
Course Code Course P Credits
PHSC 1108 Computer Applications 3 1
Hours per week
Computer Applications
Practicals: 3 h/week
Solving a problem using Algorithm, Flowchart and SDLC.
Study of Operating System; Windows and MS DOS commands
WebPage designing in MS Front Page
Prepare a document using MS Word.
Prepare a Spreadsheet/worksheet using MS Excel.
Prepare a presentation using MS Power point.
Simple Programe in ‘C’ language.
Books Recommended:
1. “Computers Today” by Senders D. H., McGrawHill.
2. “Computer fundamentals” by P. K. Sinha. Third edition, BPB Publication.
3. “Information technology”, Jaiswal, S., Galgotia Pub.
4. Manuals for MS DOS, MS Office, MS Windows, UNIX.
5. “Office 2000/2003 Complete”, BPB Publication.
6. “Internet basic reference A to Z”, by Falk B., BPB, Delhi
7. “Operating Systems” by Stallings,PHI.
8. “Computers in Pharmacy” by Thakur P.S.,Manchanda R.Nand P; Birla Pub.Pvt Ltd.
9. “Programming in ANSI-C by E. Balaguruswamy –Tata Mc. Graw Hill.
10. “Computer Networks” by Tenenbaum A.S., Prentice Hall of India.
11. “Programming with C” by Byron Gottfield.
Course Code Course P Credits
Pharmaceutical Chemistry- I
PHSC 1109 3 1
(Inorganic Chemistry)
Hours per week
Limit test of Chloride, Sulphate, Iron, Lead, Arsenic in the given sample.
Books Recommended:
1. Block, J.H., Roche, E., Soine, T. and Wilson, C., “Inorganic, Medicinal and Pharmaceutical Chemistry”,
Lea and Febiger.
2. Discher, C.A. et al., Modern inorganic pharmaceutical chemistry, Waveland press.
3. Pharmacopoeia of India, 1996
4. Atherden, L.M., Bentley and Drivers “Text book of Pharmaceutical Chemistry” Oxford University press,
London
Course Code Course P Credits
Pharmaceutical Chemistry-II
PHSC 1110 3 1
(Organic Chemistry-I)
Hours per week
Synthesis of compounds involving acetylation, benzoylation, bromination, reduction, diazotisation and oxidation.
Books Recommended:
1. Morrison, B.T., and Boyd, R.N., “Organic Chemistry”, Prentics Hall of India Pvt. Ltd., New Delhi.
Introduction to Pharmaceutics
Practicals: 3h/week
Experiments based on theory i.e., Preparation of Waters, Solutions, Syrups, Elixirs, Infusions, Decoctions,
Spirits, Jellies, Mucilages, Lotions, Liniments, Gargles, Enemas, Eye, Ear & Nasal Drops,
Practice in Pharmaceutical Calculations. Experiments based on Size Reduction, Size Separation, Filtration,
Extraction.
Books Recommended:
3. Indian Pharmacopeia.
4. British Pharmacopeia.
Microscopy: Type of microscopes, staining procedures, use of microscope in the identification of different plant
and animal part.
Gross identification of slides for structure and life cycle of lower plants and animals mentioned in theory
B.PHARM. – II SEMESTER
Course Code Course L T Credits
Applied Mathematics And
PHSC 2101 4 0 4
Biostatistics
Hours Per Week
Books Recommended:
1. Drake R.L. , Vogel W. , Mitchell AWM, “Anatomy for students” , Elsevier Publication
2. Tortora G.J. Derrockson B., “Principles of Anatomy and Physiology”, John Willey & Sons
3. Guyton A.C., Halt J.E. “Text Book of Medical Physiology” , Harcourt India Pvt. Ltd.
4. Ross and Wilson “Anatomy and Physiology in Health and Illness” , Churchil Living Stone
5. C.C. Chaterjee, “ Human Physiology, Vol. – I , Medical Allied Agencies, Calcutta
Course Code Course L T Credits
PHSC 2103 Pharmaceutical Engineering 4 0 4
Hours Per Week
Pharmaceutical Engineering
Theory: 4h/week:
Unit – I (12 Hrs):
Introduction, elements of industrial stoichiometry
Flow of fluids: Manometers, mechanism of fluid flow, Bernoulli's theorem, friction losses, enlargement
and contraction losses, measurement of flow of fluids.
Transportation of fluids: Pipe joints, pipe fittings, pumps, transportation of gases, ejectors, compressors,
blowers.
Unit – II (12 Hrs):
Flow of heat: Classification of heat flow processes, compound resistances in series, flow through
cylinder, conduction through fluids. Overall coefficients, fluids in turbulent flow in clean pipes forced and
natural convection, condensing vapours. Radiation, rate of radiation, heat transfer by radiation and
convection. Tubular heaters, heat interchangers, inductive heating.
Evaporation: Types of evaporators, jacketed kettles, tube evaporators, forced circulation evaporators
and evaporator accessories. Evaporator capacity-heat and material balances, multiple effect
evaporation, capacity of multiple effect evaporators.
Unit – III (12 Hrs):
Distillation: Theory of distillation of mixtures (a) binary mixtures of miscible liquids, (b) binary mixtures of
immiscible liquids, (c) Rectification, rectifying columns, fractionating column and simple calculations.
McCabe Thiele method for calculation of theoretical plates, Plate efficiency. Industrial equipments for
vacuum, steam, reflux and molecular distillation.
Unit – IV (12 Hrs):
Drying: Classification of dryers, compartment, tunnel, rotary, cylindrical, vacuum, spray and fluidized
bed dryers. Theory of drying, loss on drying and moisture content, equilibrium moisture content.
Principles of freeze drying, freeze dryers.
Safety Measures: Safety methods in pharmaceutical laboratories and works, mechanical, chemical,
electrical and fire hazards including inflammable gases and dusts.
Unit – V (12 Hrs):
Centrifugation: Centrifuges, Theoretical consideration, laboratory equipments, large scale equipments,
low temperature centrifuge for biological work.
Conveying: Types of conveyers, belt conveyers, chain conveyers, screw conveyers, pneumatic
conveyers. Conveyance of manufactured materials
Books Recommended:
(Hint for Unit III-V)The following topics should cover method of preparation, properties with special
emphasis wherever known:
Unit –III (09 Hrs.):
Relation of structures and properties like density , b.p., m.p., solubility etc.
Arenes and its derivatives
Phenols
Unit –IV (09 Hrs.):
Aryl halides
Sulphonic acids
Poly nuclear aromatic hydrocarbons, naphthalene, phenanthrenes
Unit –V (09 Hrs.):
Hetrocyclic compounds nomenclature, properties and reactions of pyridine, pyrrole and furan.
Polymers and polymerization-Copolymerization, ionic polymerization, coordination polymerization.
Books Recommended:
1. R.T. Morrison and R.N. Boyd: Organic Chemistry, Allyn and Bacon Inc., Boston (USA).
2. I.L. Finar: Organic Chemistry, Vol. I & II, ELBS and Longman Group Ltd., London.
3. L.M. Atherden: Bentley and Driver's-Textbookof Pharmaceutical Chemistry, Oxford University Press,
Delhi
4. F.G. Mann & B.C. Saunders: Practical Organic Chemistry, Longman, London and New York.
5. S.N. Pandeya: A Textbook of Pharmaceutical Chemistry (Heterocyclics & Biomolecules) Vol-II,
S.G.Publishers, Varanasi.
Course Code Course L T Credits
PHSC 2105 Pharmacognosy and Phytochemistry-I 4 0 4
Hours Per Week
Pharmacognosy and Phytochemistry – I
Theory: 4 Hours/Week:
Unit-I (12 Hrs.):
Definition, historical background, present status and future scope of Pharmacognosy, Definition of
selected Botanical terms and nomenclature used in Pharmacognosy.
Plant cell: cell organelles, their morphology and functions, Cell differentiation .
Introduction to Biosynthetic pathways and bimolecules.
Unit-II (12 Hrs.):
Sources of Drugs: Terrestrial, marine and microbes as source of medicine. Introduction to families such
as Apocynaceae, Compositae, Convolvulaceae, Gramineae, Labiatae, Leguminosae, Pinaceae,
Ginziberaceae, Liliaceae, Solanaceae etc. as source of important phytopharmaceuticals.
Unit-III (12 Hrs):
Classification of crude drugs: Alphabetical, Morphological, Taxonomical, Pharmacological, Chemical
and Biogenetic classifications. Organized and unorganized drugs.
General Treatment with regard to occurrence, distribution, classification, chemistry and analysis of
carbohydrates, lipids and proteins.
Study of following miscellaneous substances: Surgical fibers, Inorganic Pharmaceutical aids: Talc,
Kaolin, Bentonite, shilajit and common edible salts.
Unit-IV (12 Hrs.):
Lipids and other constituents of following: Castor , Sesame, Olive, Almond, corn Cotton seed,
Linseed, Neem, Chaulmoogra , Fish products, Theobroma, Lard, Lanolin, Beeswax and Spermaceti.
Unit-V (12 Hrs):
Detailed study on unorganized drugs with source, collection, preparation, storage, diagnostic
characters, constituents, chemical tests, substitutes, adulterants and uses of the following:
Carbohydrate and related drugs: Agar, Isabgol, Starch, Honey, Bael, Pectin, Cellulose and Cellulose
derivatives, Alginates , Gum Acacia, Gum Tragacanth and other gums and mucilages of pharmaceutical
importance.
Proteins and protein products.
Books Recommended:
1. Text Book of Pharmacognosy – C.S. Shah & J. S. Quadry
2. Text Book of Pharmacognosy – T. E. Wallis
3. Pharmacognosy – Trease & Evans
4. Pharmacognosy – Brady & Taylor
5. Text Book of Pharmacognosy – V. K. Kapoor & S.S. Handa
6. Pharmacognosy – C. K. Kokate, A.P. Purohit and S.B. Gokhale
Course Course P Credits
Code
Human Anatomy, Physiology
PHSC 2106 3 1
And Health Education
Hours per week
Practicals: 3 Hours/Week
Estimation of hemoglobin in blood, Determination of bleeding time, clotting time, R.B.C., D.L.C.and E.S.R.
Recording of body temperature, pulse rate and blood pressure, basic understanding of electrocardiogram
PQRST waves and their significance.
Books Recommended:
1. Semulingam and Prema Semulingam, “ Essential of medical Physiology” , Jaypee brothers, Medical
Publishers Pvt. Ltd. , New Delhi
2. Goyal and Patel, “Practical Anatomy and Physiology”, B. S. Sah [Prakashan, Ahmedabad
Course Course P Credits
Code
PHSC 2107 Pharmaceutical Engineering 3 1
Hours per week
Pharmaceutical Engineering
Practical: 3 hrs/week:
Books Recommended:
Practicals: 3 Hours/week:
Synthesis, Purification, Characterisation (by using solubility, melting point, and percentage purity) of organic
compounds based on the theory like 2,4,6-trinitrophenol from phenol, Iodoform from ethyl alcohol,
Phthalidimide from phthalic anhydride, Aspirin, Phenyl urea, Flourescein, Methyl orange etc..
Books Recommended:
1. Vogel’s Text Book of practical Organic Chemistry, Longman, London. New York.
2. A.A. Siddiqui & Mohd. Ali: Practical Pharmaceutical Chemistry, New Delhi.
Course Code Course P Credits
PHSC 2109 Pharmacognosy and Phytochemistry – I 3 1
Hours per week
Practicals: 3 Hours/week:
Experiments including techniques in microscopy covering section cutting, use of clearing agents, Staining agents,
mountants etc.
Use, care and focusing practices of microscope, microscopic examination of tissues and cells of herbal drugs in
section and powder form.
Histological examination and Tissue system study of at least one representative drug of each category e.g. leaf,
bark, root, rhizome, stem, fruit and seed.
Experiments on study of microscopic diagnostic ergastic characters in drugs belonging to various morphological
parts with reference to trichomes, epidermal cells, stomata, palisade, Sclerides, Vascular bundles, Secretory
glands , Starch grains and Calcium oxalate crystals.
Phyto-chemical study of unorganized drugs with reference to Chemical tests, Saponification Value, Acid value ,
Iodine value, Viscosity, Congealing points, Swelling capacity.
Books Recommended:
Unit 2 : Natural Resources : Renewable and non-renewable resources : Natural resources and associated problems.
a) Forest resources : Use and over-exploitation, deforestation, case studies. Timber extraction, mining, dams and
their effects on forest and tribal people.
b) Water resources : Use and over-utilization of surface and ground water, floods, drought, conflicts over water, dams-
benefits and problems.
c) Mineral resources : Use and exploitation, environmental effects of extracting and using mineral resources, case
studies.
d) Food resources : World food problems, changes caused by agriculture and overgrazing, effects of modern
agriculture, fertilizer-pesticide problems, water logging, salinity, case studies.
e) Energy resources : Growing energy needs, renewable and non renewable energy sources, use of alternate energy
sources. Case studies.
f) Land resources : Land as a resource, land degradation, man induced landslides, soil erosion and desertification.
• Role of an individual in conservation of natural resources.
• Equitable use of resoureces for sustainable lifestyles. (8 lectures)
Unit 3 : Ecosystems
• Concept of an ecosystem. • Structure and function of an ecosystem.
• Producers, consumers and decomposers. • Energy flow in the ecosystem.
• Ecological succession. • Food chains, food webs and ecological pyramids.
• Introduction, types, characteristic features, structure and function of the
following ecosystem :-
a. Forest ecosystem b. Grassland ecosystem c. Desert ecosystem
d. Aquatic ecosystems (ponds, streams, lakes, rivers, oceans, estuaries) (6 lectures)
Physical Pharmaceutics
Theory: 4h/week
Unit – I (12 Hrs):
State of matter: State of matter, gaseous state, liquid state, solid and crystalline state, liquid crystalline
state, phase equilibrium and phase rule (one component, two component system containing liquid phase
and solid & liquid phase), thermal analysis.
Kinetics and drug stability: Rate and order of reactions, factors affecting rate of reaction,
decomposition and stabilization of medicinal agents, kinetics in the solid state, accelerated stability
analysis
Unit – II (12 Hrs):
Diffusion and Dissolution: Steady state diffusion, procedures and apparatus, dissolution and drug
release, diffusion principles in biologic systems, vapour sorption and transmission, thermodynamics of
diffusion, diffusion and ecology.
Micromeritics: Particle size and size distribution, methods for determining particle size, particle shape
and surface area, methods for determining surface area, pore size, derived properties of powders.
Unit – III (12 Hrs):
Rheology: Introduction, newtonian system, Non Newtonian system, thixotropy, determination of
rheologic properties, viscoelasticity, psychorheology, applications to Pharmacy.
Surface and interfacial phenomena: Liquid interfaces, adsorption at liquid interfaces, adsorption at
solid interfaces, electrical properties of interfaces.
Colloids: Introduction, Types of colloidal systems, optical, kinetic and electric properties of colloids,
solubilization.
Unit – IV (12 Hrs):
Coarse Dispersions: Suspensions, interfacial properties of suspended particles, settling in suspensions,
Emulsions, theories of emulsification, physical stability of emulsions, preservation of emulsions,
rheologic properties of emulsions, phase equilibria and emulsion formulation, special emulsion
systems.
Complexation and Protein Binding: Metal complexes, organic molecular complexes, inclusion
compounds, methods of analysis, protein binding, complexation and drug action, crystalline structure of
complexes, thermodynamic treatment of stability constants.
Unit – V (12 Hrs):
Compaction and compression: Compression characteristics of powders and granules, physics of tablet
compression, measurement of punch forces, transmission of forces through powders, distribution of
forces in powder mass, factors affecting strength of tablets.
Crystallization: Introduction, Nucleation and crystal growth, crystal type, theory of crystallization,
batch crystallizers, simple vacuum crystallizers, prevention of crystals caking,
Books Recommended:
1. Physical Pharmacy - Martin, Swarbrick & Cammarata.
2. Physical Pharmaceutics - Schotton
3. Remington's Pharmaceutical Sciences.
4. An introduction to Chemical Engineering - Badger and Banchero.
5. Chemical Engineering - Richardson and Coulson.
6. Introduction to Unit Operation - McCabe and Smith.
7. Theory and Practice of Industrial Pharmacy-Lachman,Lieberman and Kanig
8. Bentley's Text Book of Pharmaceutics - Rowlin.
B.PHARM. – III SEMESTER
Course Course L T Credits
Code
PHSC 3102 CELL AND MOLECULAR BIOLOGY 2 0 2
Hours Per Week
Proteins and amino acids: Isolation and classification of proteins, hydrolysis, fibrous and globular
proteins, classification, methods of synthesis and properties of amino acids, nucleoproteins and nucleic acids
and general knowledge of nitrogenous bases in nucleic acids, structure of nucleosides and nucleotides,
structure of nucleic acids.
Flavones & isoflavones, coumarines, porphyrines
Lipids fats oils and waxes,fatty acids: Characterization and their physico-chemical properties, general
knowledge of phospholipids ,lecithins, cephalines, sphingomyeline, glycolipids,lipoproteins.
Terpenes: Isolation, classification, general methods of determining structure with reference to citral,
carvone, thymol, menthol and camphor. An elementary treatment of rubber.
Alkaloids: General methods of determining structure of alkaloids, classification with an acquaintance with
the structure of alkaloids of IP, structure elucidation of ephedrine, nicotine and xanthine derivatives like
caffeine, theobromine and theophylline.
Books Recommended:
1. Finar, I.L. Organic Chemistry, Vol.-I and II, ELBS/Longman.
2. Acheson, “An introduction to heterocyclic compounds”
3. Indian Pharmacopoeia.
4. Hendrikson, Organic Chemistry
B.PHARM. – III SEMESTER
Course Course L T Credits
Code
PHSC 3104 PHARMACEUTICAL MICROBIOLOGY 4 0 4
Hours Per
Week
Pharmaceutical Microbiology
Unit-I (12 Hrs.):
Introduction to the scope of microbiology, Historical background, Scope of Microbiology
Classification of microbes and their taxonomy. Actinomycetes, bacteria, rickettsiae, spirochetes and
viruses.
Unit-II (12 Hrs.)
Identification of microbes: stain and types of staining techniques, electron microscopy.
Nutrition, cultivation, isolation and identification of bacteria, actinomycetes, fungi, viruses.
Unit-III (12 Hrs.):
Control of microbes by physical and chemical methods
A. Disinfection, factors influencing disinfectants, dynamics of disinfection, disinfectants,
antiseptics and their evaluation.
B. Sterilization: different methods, validation of sterilization methods and equipments.
C. Clean area classification
Sterlity testing of pharmaceutical products, preservative efficacy.
Microbial assay of antibiotics and vitamin B12.
Unit-IV (12 Hrs.):
Immunology and immunological preparations: principles, antigens and haptens, immune system,
cellular and humoral immunity, immunological tolerance, antigen-antibody reactions and their
applications.
Hypersenstivity, active and passive immunization products, their preparation, standardization and
storage.
Books Recommended:
1. G. Gunnz & S.J. Carter “Cooper & Gunn’s Tutorial Pharmacy”, 6th ed., Pitman Medical Publishing Co.,
London 1972.
2. W.B. Hugo and A.D. Russell “Pharmaceutical Microbiology”, 4th ed., Blackwell Scientific Publication,
Oxford, 1987.
3. “Microbiology”- Davis, Dulbecco, Eisen.
4. “Remington’s Pharmaceutical Sciences” Gennaro A.R. Ed., 18th ed., Mack Publishing Co., Easton, Pa, USA,
1990.
5. L.M. Prescott, G.P. Jarly, D.A. Klein, “Microbiology” 2nd, ed. Wm. C. Brown Publishers, Oxford, 1993.
6. S.P. Vyas, V.K. Dixit,”Pharmaceutical Biotechnology“1st ed. CBS Publishers & Distributors, New Delhi,
1998.
7. N.K. Jain,”Pharmaceutical Microbiology” Vallabh Prakashan, Delhi.
8. K. Kieslich, Ed. “Biotechnology” vol. VI a, Verlag Chamie, Switzerland, 1984.
9. G. Reeves “Lecture Notes on Immunology” Blackwell Scientific Publication, Oxford, 1987.
10. Laboratory Manual of Bacteriology- Salle
B.PHARM. – III SEMESTER
Course Course L T Credits
Code
PHARMACOGNOSY AND
PHSC 3105 4 0 4
PHYTOCHEMISTRY-II
Hours Per Week
Unit-I (12Hrs.):
Commerce in Crude Drugs: Collection, preparation, drying and storage of drugs with special emphasis on factors influencing
quality of drugs.
Volatile Oils: Chemistry and biogenesis of medicinally important monoterpenes, sesquiterpenes, diterpenes and triterpenes.
Study of important drugs yielding essential oils like Mentha, Coriander, Cinnamon, Cassia, Lemon peel, Orange peel, Lemon
grass, Citronella, Caraway, Dill, Spearmint, Clove, Fennel, Nutmeg, Eucalyptus, Chenopodium, Cardamam, Valerian, Musk,
Palamarosa, Gaultheria, Sandalwood.
Unit-II (12Hrs.):
Resins: classification and medicinal importance.
Study of some important resin containing drugs
Colophony, Podophyllum, Jalap, Canabis, Capsicum, Myrrh, Asafoetida, Balsam of Tolu,
Balsam of Peru, Benzoin, Turmeric, Ginger etc.
Tannins Classification, chemistry, uses and medicinal significance.
Important drugs of this category like Gambir, Black Catechu, Pale Catechu, Myrobalan etc.
Unit-III (12Hrs.):
Proteins and enzymes:
Sources, Preparation, Identification test, Chemical nature, and uses of papain, pepsin,
pancreatin, urokinase, diastase, trypsin, penicillinase, hyaluronidase.
Marine Pharmacognosy: Study of novel agents from marine sources
Unit-IV (12Hrs.):
Quality Control and Standardization:
Introduction, classification,and study of different chromatography methods and their methods and their applications in evaluation
of herbal drugs.
Extractive values, Ash values, Chromatographic techniques (TLC, HPTLC, HPLC), Concept of marker compounds
WHO Guidelines for rational use of herbal drugs
Unit V (12Hrs.):
Herbal constituents as health foods and cosmetic ingredients, Natural allergens, photosensitizing agents, Fungal and mushroom
toxins, poisonous plants
Chemistry and biogenesis of medicinally important lignans, quassinoids and flavonoids
Concept of synergy in herbs
Radio Tracer Techniques and their utilization in elucidation of biosynthetic pathways in plants
BOOKS RECOMMENDED
1. Pharmacognosy: Trease and Evans
2. Pharmacognosy: Tyler and Brady
3. Pharmacognosy – C. K. Kokate, A.P. Purohit and S.B. Gokhale
4. A Text Book of Pharmacognosy – C.S. Shah & J. S. Quadry
5. A Text Book of Pharmacognosy – T. E. Wallis
6. Text Book of Pharmacognosy – V. K. Kapoor & S.S. Handa
7. Pharmacopoeia of India.
B.PHARM. – III SEMESTER
PHYSICAL PHARMACEUTICS
Practicals: 3 Hours/Week
1. Experiments based on phase rule,
2. Experiments based on dissolution and diffusion,
3. Experiments based on micromeritics,
4. Experiments based on rheology and thixotropy,
5. Experiments based on interfacial and surface tension,
6. Experiments based on colloids, suspensions, and emulsions,
7. Experiments based on complexation & drug protein binding,
8. Experiments based on compaction and compression,
9. Experiments based on crystallization.
Books Recommended:
1. Physical Pharmacy - Martin, Swarbrick & Cammarata.
2. Physical Pharmaceutics - Schotton
3. Remington's Pharmaceutical Sciences.
4. An introduction to Chemical Engineering - Badger and Banchero.
5. Chemical Engineering - Richardson and Coulson.
6. Introduction to Unit Operation - McCabe and Smith.
7. Theory and Practice of Industrial Pharmacy-Lachman,Lieberman and Kanig
8. Bentley's Text Book of Pharmaceutics - Rowlin.
B.PHARM. – III SEMESTER
Books Recommended:
1. Finar, I.L. Organic Chemistry, Vol.-I and II, ELBS/Longman.
2. Acheson, “An introduction to heterocyclic compounds”
3. Indian Pharmacopoeia.
4. Hendrikson, Organic Chemistry
B.PHARM. – III SEMESTER
Pharmaceutical Microbiology
Practicals: 3 Hours/Week
Experiments devised to prepare various types of culture media, sub-culturing of common aerobic and
anaerobic bacteria, fungus, and yeast, various staining methods, various methods of isolation and
identification of microbes, sterilization techniques and their validation evaluation of antiseptics and
disinfectants, testing the sterility of pharmaceutical products as per IP requirements, microbial assay of
Books Recommended:
1. G. Gunnz & S.J. Carter “Cooper & Gunn’s Tutorial Pharmacy”, 6th ed., Pitman Medical
Publishing Co., London 1972.
2. W.B. Hugo and A.D. Russell “Pharmaceutical Microbiology”, 4th ed., Blackwell Scientific
Publication, Oxford, 1987.
3. “Microbiology”- Davis, Dulbecco, Eisen.
4. “Remington’s Pharmaceutical Sciences” Gennaro A.R. Ed., 18th ed., Mack Publishing Co.,
Easton, Pa, USA, 1990.
5. L.M. Prescott, G.P. Jarly, D.A. Klein, “Microbiology” 2nd, ed. Wm. C. Brown Publishers,
Oxford, 1993.
6. S.P. Vyas, V.K. Dixit,”Pharmaceutical Biotechnology“1st ed. CBS Publishers & Distributors,
New Delhi, 1998.
7. N.K. Jain,”Pharmaceutical Microbiology” Vallabh Prakashan, Delhi.
8. K. Kieslich, Ed. “Biotechnology” vol. 6a, Verlag Chamie, Switzerland, 1984.
9. G. Reeves “Lecture Notes on Immunology” Blackwell Scientific Publication, Oxford, 1987.
10. Laboratory Manual of Bacteriology- Salle
B.PHARM. – III SEMESTER
Practicals: 3 Hours/Week
1. Identification and Evaluation of Representative Pharmacopia Drugs belonging to categories mention in
theory in whole and powdered form by Morphology and Microscopy.
3. Extraction and isolation of important phytoconstituents including caffeine, piperine, solaneceous alkaloids,
podophyllotoxin,sennosides, glycyrrhizine.
Books Recommended:
1. Practical Pharmacognosy: C.K. Kokate and Purohit
2. Evaluation of Phytopharmaceuticals : Turner
3. Pharmacopia of India
4. Pharmacognosy: Trease and Evans
5. Pharmacognosy: Tyler and Brady
6. A Text Book of Pharmacognosy – C.S. Shah & J. S. Quadry
7. A Text Book of Pharmacognosy – T. E. Wallis
8. Text Book of Pharmacognosy – V. K. Kapoor & S.S. Handa
B.PHARM. IV SEMESTER
Course Code Course L T Credits
Human Physiology and
PHSC 4101 4 0 4
Pathophysiology of Common Diseases
Hours Per Week
Human Physiology and Pathophysiology of Common Diseases
Theory: 4h/week
Unit-I (12 Hrs.):
Digestive system: Gross anatomy of the gastro-intestinal tract, functions of its different parts including
those of liver, pancreas and gall bladder, various gastrointestinal secretions and their role in absorption
and digestion of food. Disorders of digestive system.
Respiratory system: Anatomy of respiratory organs and its functions, respiration, mechanism and
regulation of respiration, respiratory volumes and vital capacity.
Unit-II (12 Hrs.):
Central nervous system: Function of different parts of brain and spinal cord. Neurohumoral
transmission in the central nervous system, reflux action electroencephalopathy, specialized functions of
the brain, cranial nerves and their function.
Unit-III (12 Hrs.):
Autonomic nervous system: Physiology and functions of the autonomic nervous system. Mechanism of
neurohumoral transmission in the A.N.S.
Renal System: Various parts, structures and functions of the kidney and urinary tract. Physiology of
urine formation and acid base balance. Disease of the urinary system.
Sense organs: Basic physiology of the eye, ear, taste buds, nose and skin (superficial receptors).
Unit-IV (12 Hrs.):
Reproductive systems: Male and female reproductive systems, menstruation pathophysiology of
sexually transmitted disease, spermatogenesis, oogenesis and pregnancy.
Endocrine system: anatomy and physiology of pituitary, thyroid, parathyroid, adrenal, pancreas, control
of harmone secretion, pathophysiology of hypo and hyper secretion of endocrine glands and the
disorders e.g. diabetes mellitus.
Unit-V(12 Hrs.):
Phathophysiology of disorders related to digestive system peptic ulcers, ulcerative colitis, Crohns
disease, Zollinger Ellison syndrome, hepatic disorders- hepatitis, cirrhosis of liver, pancreatitis.
Phathophysiology of arthritis, gout, myasthenia gravis, spasticity, tetany. Fatigue, Phathophysiology of
anemia, hypersensitivity, allergic conditions, psychosis, epilepsy, AIDS, Parkinson’s and Alzheimer’s
disease and other neurodegenerative diseases, Phathophysiology of cataract and glaucoma.
Books Recommended:
1. C.C. Chatterjee. Human Physiology.
2. J.W. Kathleen, Ross and Wilson. Anatomy and Physiology in Health and Illness
3. G.J. Tortora and B. H. Derrickson. Principles of Anatomy and Physiology, 11th edition. 2004. John
Wiley & Sons.
4. C. Arthur, M.D. Guyton, John E. Hall. Textbook of Medical Physiology.
5. G. Pocock and C.D. Richards. Human Physiology: The Basis of Medicine. 3rd edition. 2004.
B.PHARM. IV SEMESTER
Course Code Course L T Credits
PHSC 4102 Dosage Form Design 4 0 4
Hours Per Week
Dosage Form Design
Unit – I (12 Hrs):
1. Preformulation study: (a) Study of physical properties of drug like physical form, particle size,
shape, density, wetting, dielectric constant, solubility, dissolution and organoleptic properties and
their effect on formulation, stability and bioavailability.
(b) Study of chemical properties of drugs like hydrolysis, oxidation-reduction, racemisation,
polymerization etc. and their influence on formulation and strength of products, stabilization and
stability testing protocol provision pharmaceutical products.
(c) Study of prodrugs in solving problems related to stability, bioavailability and elegancy of
formulation.
Unit – II (12Hrs):
2. Polymer sciences: Introduction, classification and pharmaceutical applications of polymers,
Polymers as thickening agents, Preparing polymer solutions, Phase separation, Gel formation,
Mechanical properties of polymeric films, Future trends in pharmaceutical and other biomedical uses
of polymers.
Unit – III (12 Hrs):
3. Process validation: Prospective, concurrent, ritroprospective and revalidation. Process capability
and statistical evaluation of process validation data. Process validation of following formulation:
Uncoated tablets, capsules, small volume injectables, oral liquids, ointment/cream. Regulatory
requirements for validation.
4. SOP for different dosage forms: Introduction and purpose of SOPs, benefits and types of SOPs,
SOP development and format. SOP of oral liquids, tablet and capsule manufacturing.
Unit – IV (12 Hrs):
5. Optimization techniques in pharmaceutical operation and processes: Introduction, optimization
parameters, methods used for optimization, applications of optimization.
6. Good manufacturing practice for pharmaceuticals: Brief introduction of cGMP and GLP,
practice of GMP and WHO guidelines. Quality assurance and quality audit.
Unit – V (12 Hrs):
7. Mixing: Mechanism of mixing, equipment and selection, solid-solid, solid-liquid and liquid-liquid
mixers used in pharmaceutical industry.
8. Material for construction of Pharmaceutical Plant: The nature, properties and uses of important
materials employed in the construction of plants. Corrosion heat and corrosion resistant alloys and
other materials, methods of reducing corrosion, protective coating.
Books Recommended:
1. G. S. Banker and C. T. Rhodes. Modern Pharmaceutics. 4th edition. 2002. Maecell Dekker.
2. Syad Imtiaz Haider. Pharmaceutical Master Validation Plan. Special Indian edition. 2001, CRC Press.
3. P.P. Sharma. How to Pracitise GMPs. A plan for total quality control. 2nd edition, Vandana Publication.
4. Sidney H. Willig, Murray M. Tuckerman and William S. Hitchings IV. Good Manufacturing Practices for
Pharmaceutics: A Plan for Total Quality Control. 2nd edition. Marcel Dekker.
5. A.R. Gennaro. Remington's Pharmaceutical Sciences. 18th edition. Mack Publishing Co. Pennsylvania, USA 1990.
6. Gilbert S. Banker and Cristopher T. Rhodes. Modern Pharmaceutics Drugs and Pharmaceutical Science. Series vol. 7.
1979. M&D Inc. New York.
7. Leon Lachman. The Theory and Practice of Industrial Pharmacy. 2nd edition, Indian Edition, 1976, K.M. Varghese Co.,
Bombay.
8. E.A. Rawlins. Bentley's Textbook of Pharmaceutics,, 8th edition, 1977, Bailliere Tindall, London, England
9. S.J. Carter-Cooper and Gun's Tutorial Pharmacy, VI Ed., 1072, Pitman Medical.
10. Pharmacopoeia of India, 1996, Controller of Publication. Ministry of Health and Family Welfare, Govt. of India. Delhi,
11. British Pharmacopoeia, 1994.
12. A. Martin, J. Swarbrick and A. Cammarata. Physical Pharmacy. Lea and Febiger, Philadelphia
13. D.H. Shah. SOP guidelines. 2004. Published by Business Horizones.
B.PHARM. IV SEMESTER
Course Code Course L T Credits
PHSC 4103 Pharmaceutical Biotechnology 4 0 4
Hours Per Week
Pharmaceutical Biotechnology
Theory: 4h/week
Unit-I (12 Hrs.):
Active, Passive immunization: Vaccines, types of Vaccines and principle involved, their preparations,
standardization and storage.
Unit-II (12 Hrs.):
Genetic Recombination, Transformation, Conjugation, Transduction, Protoplast fusion and gene cloning
and their applications. Development of hybridoma for monoclonal antibodies. Study of drugs produced
by biotechnology such as Activase, Humulin, Humatrope, HB etc.
Unit-III (12 Hrs.):
Antibiotics: Historical development of antibiotics. Antimicrobial spectrum and methods used for their
standardization. Screening of soil for organisms producing antibiotics, fermenter, its design, control of
different parameters. Isolation of mutants, factors influencing rate of mutation. Design of fermentation
process. Isolation of fermentation products with special reference to penicillins, streptomycins
tetracyclines and vitamin B12.
Unit-IV (12 Hrs.):
Microbial Transformation: Introduction, types of reactions mediated by microorganisms, design of
biotransformation processes, selection of organisms, biotransformation process and its improvements
with special reference to steroids.
Unit-V (12 Hrs.):
Enzyme immobilization: Techniques of immobilization, factors affecting enzyme kinetics. Study of
enzymes such as hyaluronidase, penicillinase, streptokinase and streptodornase, amylases and proteases
etc. Immobilization of bacteria and plant cells.
6. Historical development of plant tissue culture, types of tissue cultures, their nutritional requirements,
growth and main features, Applications of plant tissue culture in pharmacy.
Books Recommended:
1. S.P. Vyas and A. Mehta. Cell and Molecular Biology. CBS Publishers, New Delhi
2. S.P. Vyas and V.K. Dixit. Pharmaceutical Biotechnology. CBS Publishers, New Delhi.
3. Elliott, W.C. & and Elliott, D.C. Biochemistry and Molecular Biology, 2nd edition, 2001. Oxford University Press
4. B.R. Glick and J.J. Pasternak. Molecular Biotechnology: Principles and Applications of Recombinant DNA:
(1998) ASM Press Washington D.C.
5. S.B. Primrose. Molecular Biotechnology. 2nd edition, 1999. Blackwell Scientific Publication.
6. Medical Immunology. 10th edition, International edition, Lange, McGraw-Hill Companies, ISBN- New Delhi.
7. Oskar Zaborsky. Immobilized Enzymes. 1973. CRC Press, Degraland, Ohio.
B.PHARM. IV SEMESTER
Course Code Course L T Credits
PHSC 4104 Pharmaceutical Analysis I 4 0 4
Hours Per Week
Pharmaceutical Analysis I
Theory: 4h/week
Unit –I (12 Hrs.):
The course shall cover-computation of analytical results, Significant figures, Concept of error, Precision and
Accuracy, Standard deviations, Rejection of doubtful values with special reference to volumetric and
gravimetric analysis, Calibration of analytical equipments. Fundamentals of volumetric analysis, method of
expressing concentrations, primary and secondary standards.
Fundamentals of following volumetric analysis techniques-
Unit –II (12 Hrs.):
Acid Base Titrations: Acid base concepts, Role of solvents, Relative strengths of acids and bases,
Ionization, Law of mass action, Common ion effect, Ionic product of water, pH, Hydrolysis of salt,
Henderson-Hesselbach equation, buffer solutions, Neutralization curve, Acid-base indicators, Choice of
indicators, mixed indicators, polyprotic systems, polyamine and amino acid systems, amino acid titration,
differential titration, Assay of sodium carbonate, sodium hydroxide etc.
Unit –III (12 Hrs.):
Oxidation Reduction Titration: Concept of oxidation and reduction, Oxidation numbers, Half reactions,
Strength and equivalent weight of oxidizing and reducing agents, Theory of redox titrations, Redox
indicators. Redox titrations Principles and Techniques using potassium permanganate, potassium
dichromate, Cerric sulphate, Iodine-iodate, Bromide-bromate, Titanous chloride solutions.
Group Estimations: Determination of aldehyde, ketones, hydroxyl, phenolic, carboxylic acid, methoxy
groups as applied to photochemicals.
Use of Polarimetry, Refractometry in analysis of drugs.
Books Recommended:
1. J. Mendham, R.C. Denney, J.D. Barnes and M.J.K. Thomas. Vogel’s Text Book of Quantitative
Chemical Analysis.
2. A.H. Beckett and I.B. Stenlake, Practical Pharmaceutical Chemistry. Part I & II. The Athlone Press,
London
3. K.A. Connors. A Text Book of Pharmaceutical Analysis. Johan Wiley & Sons.
4. Pharmacopoeia of India.
B.PHARM. IV SEMESTER
Course Code Course L T Credits
Pharmacy Practice (Dispensing and
PHSC 4105 4 0 4
Community Pharmacy)
Hours Per Week
Pharmacy Practice (Dispensing and Community Pharmacy)
Theory: 4h/week
Unit – I (12 Hrs):
1. Prescription: Definition, parts, handling, sources of errors in prescriptions, knowledge of latin terms
commonly used in prescription writing and their translation into English. Modern concepts of dispensing
pharmacy.
1. Compounding of medication: Powders, Tablets, Capsules, Tablet triturates, Pills, Lozenges, Ointments,
Creams, Pastes, Jellies, Suppositories, Suspensions, Emulsions, Mixtures, Sprays, Inhalations, Paints.
Labeling of dispensed products.
Unit – II (12 Hrs):
2. Incompatibility: Physical, chemical and therapeutic incompatibilities and their corrections.
3. Radiopharmaceuticals: Radioactivity and radionuclide, Production of radiopharmaceuticals, Radioactive
decay, Measurement of radiation, Radiopharmaceutical dosage forms, methods of radiation detection,
radiopharmaceutical having therapeutic/ diagnostic applications, storage and handling of radiopharmaceutical
products. Environmental control and protection against exposure to radiopharmaceuticals.
Unit – III (12 Hrs):
4. Community pharmacy: Introduction and management. Community Pharmacy Organization and structure of
retail and wholesale drug store- types of drug stores and design - Legal requirements for establishment,
maintenance of drug store, Dispensing of proprietary products, Maintenance of records of retail and whole
sale.
5. Inventory Control in community Pharmacy: Definition, various methods of inventory control. ABC, VED,
EOQ, Lead time, safety, stock.
Unit – IV (12 Hrs):
6. Pharmaceutical care: Definition and principles of pharmaceutical care. Emergency treatment in shock,
snake-bite, burns, poisoning, heart diseases, fractures, resuscitation methods. Elements of minor surgery and
dressings.
Unit – V (12 Hrs):
7. Health education: WHO definition, health promotion care of child, pregnant & breast feeding women and
geriatric patient, role of pharmacist in family planning. Prevention of communicable diseases i.e.,
tuberculosis, hepatitis, leprosy, AIDS, syphilis, gonorrhea.
Books Recommended:
1. Hoover ‘s Dispensing of medication. Mack Publishing.
2. Joseph Barnett Sprowls. Prescription Pharmacy.
3. S. J. Carter. Cooper and Gunn's Dispensing for Pharmaceutical Students: Carter. 11th edition. CBS Publishers.
4. N.K. Jain and S.N. Sharma. The Concise Pharmaceutical Dispensing. Vallabh Prakashan, Delhi.
5. N.K. Jain. Health Education and Community Pharmacy. CBS Publishers.
B.PHARM. IV SEMESTER
Course Code Course P T Credits
Human Physiology and
PHSC 4106 Pathophysiology of Common 3 0 1
Diseases (Practical)
Hours Per Week
Books Recommended:
1. Shukant R. Apte. Experimental Physiology.
2. Ramesh K. Goyal, Natyar M. Patel and Shailesh A. Shah. Practical Anatomy, Physiology and Biochemistry.
3. Sir John Y. Dacie and S. M. Lewis. Practical Haematology.
B.PHARM. IV SEMESTER
Course Code Course P T Credits
PHSC 4107 Dosage Form Design (Practical) 3 0 1
Hours Per Week
Dosage Form Design (Practical)
Practical: 3h/week
• Experiments on polymer science, mixing and standard operational procedure.
Books Recommended:
1. G. S. Banker and C. T. Rhodes. Modern Pharmaceutics. 4th edition. 2002. Maecell Dekker.
2. P.P. Sharma. How to Pracitise GMPs. A plan for total quality control. 2nd edition, Vandana
Publication.
3. A.R. Gennaro. Remington's Pharmaceutical Sciences. 18th edition. Mack Publishing Co.
Pennsylvania, USA 1990.
4. Gilbert S. Banker and Cristopher T. Rhodes. Modern Pharmaceutics Drugs and Pharmaceutical
Science. Series vol. 7. 1979. M&D Inc. New York.
5. Leon Lachman. The Theory and Practice of Industrial Pharmacy. 2nd edition, Indian Edition, 1976,
K.M. Varghese Co., Bombay.
6. E.A. Rawlins. Bentley's Textbook of Pharmaceutics,, 8th edition, 1977, Bailliere Tindall, London,
England
7. S.J. Carter-Cooper and Gun's Tutorial Pharmacy, VI Ed., 1072, Pitman Medical.
8. Pharmacopoeia of India, 1996, Controller of Publication. Ministry of Health and Family Welfare,
Govt. of India. Delhi,
9. British Pharmacopoeia, 1994.
10.A. Martin, J. Swarbrick and A. Cammarata. Physical Pharmacy. Lea and Febiger, Philadelphia
B.PHARM. IV SEMESTER
Course Code Course P T Credits
Pharmaceutical Biotechnology
PHSC 4108 3 0 1
(Practical)
Hours Per Week
Pharmaceutical Biotechnology (Practical)
Practicals: 3h/week
Practical: 3h/week
Practice in Dispensing of not less then 100 prescriptions comprising of Solutions, Mixtures, Powders,
Tablets, Capsules, Lozenges, Ointments, Creams, Pastes, Jellies, Suppositories, Suspensions, Emulsions,
Sprays, Inhalations, Paints, Incompatibilities.
Books Recommended:
1. Hoover’s Dispensing of medication. Mack Publishing.
2. Joseph Barnett Sprowls. Prescription Pharmacy.
3. S.J. Carter. Cooper and Gunn's Dispensing for Pharmaceutical Students: Carter. 11th edition. CBS
Publishers.
4. N.K. Jain and S.N. Sharma. The Concise Pharmaceutical Dispensing. Vallabh Prakashan, Delhi.
5. N.K. Jain. Health Education and Community Pharmacy. CBS Publishers.
B.PHARM. V SEMESTER
Course Code Course L T Credits
PHSC 5101 Cosmetic Technology 4 0 4
Hours Per Week
Cosmetic Technology
Theory: 4h/week
Unit-I (12 Hrs.):
1. Introduction to cosmetics, their applications, origin and development of cosmetic sciences.
2. Basic knowledge of skin, role of hormones and vitamins in skin nutrition.
3. Dermatitis and allergy, primary irritants, photosensitization, allergy and antihistaminics in cosmetics.
(Hint for Unit – III to V ) Formulation, manufacturing and equipments used for the following types of
cosmetic preparations.
Unit-III (12 Hrs.):
Skin creams and lotions, classification of skin creams, cold, vanishing, all purpose and emollient
creams, cleansing creams, foundation creams, hand creams, protective and barrier creams.
Biochemistry
Theory: 4h/week
Unit-I (12 Hrs.):
Biochemistry and its importance in Pharmaceutical Sciences.
Biochemical organization of the cell, production of cell energy, ATP and its biological significance.
biochemical importance of colloidal systems, Donnan effect.
Unit-II (12 Hrs.):
Enzymes: Classification, nomenclature, factors affecting enzyme action, enzyme kinetics, mode and
mechanism of enzyme action and inhibition, isozymes and their importance in diagnosis.
Vitamins as co-enzymes and their significance, metals as co-factors.
Carbohydrate Metabolism: Classification, glycolysis, citric acid cycle, glycogenesis and glycogenolysis.
hexose monophosphate shunt, uronic acid pathway, blood sugar and its regulation.
Unit-III (12 Hrs.):
Lipid Metabolism: Oxidation of fatty acids, biosynthesis of fats, ketogenesis and ketosis. metabolism of
cholesterol. essential fatty acids and eicosanoids phospholipids, sphingolipids.
Biological oxidation and reduction, respiratory chain, oxidative phosphorylation. enzymes and co-enzymes
of Bioredox system.
Unit-IV (12 Hrs.):
Metabolism of Amino Acids and Proteins: General biochemical reaction of amino acids like transamination,
deamination and decarboxylation. metabolism of sulphur containing amino acids, urea cycle, nitrogen
balance, biosynthesis of bile salts and bile pigments.
Metabolism of Nucleic Acids: Biosynthesis and catabolism of purines and pyrimidines containing
nucleotides.
Unit-V (12 Hrs.):
Biosynthesis of DNA and its replication, mutation and repair mechanism.
An introduction to genetic engineering, biosynthesis of RNA, genetic code and protein synthesis.
Liver and kidney function tests of biochemical importance.
Detoxification mechanisms like oxidation, hydrolysis, reduction & conjugation.
BOOKS RECOMMENDED
1. D.W. Martin, P.A. Mays and V.M. Redwell, Harpers Review of Biochemistry, Lunge Medical
Publication.
2. Harpers Review of Biochemistry, Langue Medical Publication.
3. A.L.Lehninger, Biochemistry, Worth Publisher Inc.
4. A.L.Lehninger, Principle of Biochemistry, CBS publishers and Distributors.
5. L. Striae, Biochemistry, W.H. Freeman & Co. San Francisco.
6. B.Harrow and A.Mazur, Text Book of Biochemistry,W.B.Saunders Co.Philadelphia.
7. Text book of Biochemistry - West and Todd.
8. Elements of Biochemistry-O.P.Agrawal, Goel Publishing,House, Meerut
B. PHARM. V SEMESTER
Course Code Course L T Credits
PHSC 5103 Medicinal Chemistry I 3 0 3
Hours Per Week
Medicinal Chemistry I
Theory: 3h/week
(Hint For Unit-II to Unit-V : The following topics shall be treated covering chemical naming, structure activity
relationship, physicochemical and steric aspects, mode of action and uses. The emphasis would be mainly on BP
and IP drugs, synthesis of only those drugs given in parenthesis under each topic would be covered)
Unit –II (09Hrs.):
Adrenergic hormones and drugs including biosynthesis, storage, release and metabolism of catecholamines
(Adrenaline, isoprenaline, salbutamol, amphetamine and naphazoline)
Cholinergics and anticholinesterases including biosynthesis, storage, release and metabolism of Ach
(methacholine chloride, neostigmine bromide)
Unit –III (09Hrs.):
Antispasmodic & antiulcer drugs (cyclopentolate, propantheline bromide, benzhexol)
Antiparkinsonism drugs (apomorphine)
Neuromuscular blocking agents (gallamine triethiodide, succinylcholine chloride)
Unit –IV (09Hrs.):
Hypoglycaemic drugs (tolbutamide)
Thyroid hormones and antithyriod drugs (L-thyroxine, propylthiouracil)
Anticoagulants and haemostatic agents (warfarin, phenindione )
Unit –V (09Hrs.):
Oxytocics (including discussion on ergot alkaloids also) (ergometrine)
Antihistamines including discussion on sodium cromoglycate (mepyramine, diphenhydramine,
chlorpheniramine, promethazine)
NSAIDS includes anti-gout drugs also (Indomethacin, phenylbutazone, allopurinol, probenecid).
BOOKS RECOMMENDED
• Foye, W.C. “Principles of Medicinal Chemistry” Lea and Febiger, Philadelphia
• Wilson and Giswold’s “Textbook of Organic, Medicinal and Pharmaceutical Chemistry” J. Lippincott
Co., Philadelphia.
• Burger’s Medicinal Chemistry, John Wiley and Sons, Newyark
• Singh and Kapoor “A Text Book of Pharmaceutical and Medicinal Chemistry” Vallabh Prakashan, New
Delhi.
B.PHARM. V SEMESTER
Course Code Course L T Credits
PHSC 5104 Pharmacology-I 3 0 3
Hours Per Week
Pharmacology-I
Theory: 3h/week
Unit-I (09 Hrs.):
General Pharmacology: Introduction to pharmacology, sources of drugs. Dosage forms and different routes
of administration. Factors modifying drug action and dosage forms, pharmacodynamics – different types of
drug actions and their mechanisms. Adverse drug reactions.
Unit-I (9 Hrs.):
Systematic Study of Crude Drugs: Including synonyms, biological / geographical sources, identification, chemical
constituents, chemical tests, uses, adulteration and evaluation of glycosidal drugs of following groups:
Anthraquinone glycosidal drugs: Senna, Aloe, Rhubarb, Cascara etc.
Saponin glycosidal drugs: especially, Dioscorea, Solanum, Licorice, Senega, Ginseng.
Cyanogenetic glycosidal drugs: Wild Cherry.
Coumarins and Furanocoumarin glycosidal drugs including Psoralea.
Miscellaneous glycosidal drugs: Gentian, Quassia, and Saffron etc.
Unit-II (9 Hrs.):
Systematic Study of Crude Drugs: Including synonyms, biological / geographical sources, identification, chemical
constituents, chemical tests, uses, adulteration and evaluation of Alkaloidal drugs of following groups:
Indole alkaloidal drugs : especially Ergot, Nux-vomica, Rauwolfia, Catharanthus.
Isoquinoline alkaloidal drugs: including Ipecac, Opium, Curare.
Tropane alkaloidal drugs: Stramonium, Hyoscyamus, Datura, Belladonna, Duboisia etc.
Quinoline alkaloidal drugs: including Cinchona.
Pyridine alkaloidal drugs: especially Areca, Lobelia, Nicotiana.
Imidazole alkaloidal drugs: including Pilocarpus.
Quinazoline alkaloidal drugs: including Vasaka.
Steroidal alkaloidal drugs: especially Ashwagandha, Kurchi, Veratrum, Solanum.
Proto-alkaloidal drugs: Ephedra, Colchicum etc.
Terpenoid alkaloidal drugs: including Aconite.
Unit-III (9 Hrs.):
Phytochemical Screening:
Preparation of extracts, Phytochemical tests for detection of common plant constituents, Biosynthetic pathways for secondary
plant constituents, General principles of formation of primary and secondary plant metabolites. Biogenesis of medicinally
important glycosides, alkaloids, carbohydrates, lipids, volatile oils and steroids.
Unit-IV (9 Hrs.):
Utilization and production of phytoconstituents from aromatic and medicinal plants: Isolation of the following phyto-
constituents (including industrial methods):
Morphine, Quinine, Reserpine, Sennosides, Digitalis glycosides, Diosgenin, Menthol, Thymol, Rutin, Psoralen.
Unit-V (9 Hrs.):
Classification and general treatment of alkaloids and glycosides of different categories including methods of isolations physico
chemical properties and chemical tests for identification.
Books Recommended:
1. Pharmacognosy: Trease and Evans
2. Pharmacognosy: Tyler and Brady
3. Pharmacognosy – C. K. Kokate, A.P. Purohit and S.B. Gokhale
4. A Text Book of Pharmacognosy – C.S. Shah & J. S. Quadry
5. A Text Book of Pharmacognosy – T. E. Wallis
6. Text Book of Pharmacognosy – V. K. Kapoor & S.S. Handa
7. Pharmacopia of India
B. PHARM. V SEMESTER
Course Code Course L T Credits
PHSC 5106 Cosmetic Technology 3 0 1
Hours Per Week
Cosmetic Technology (Practical)
Practical: 3h/week
Preparation of following types of cosmetic preparation based on the theory :
1) Creams:
i) Cold cream ii) Vanishing cream iii) Cleansing cream iv) Emollient cream v) All purpose cream vi)
Foundation cream
2. Face powders and make-up:
i) Face powder ii) Dusting powder iii) Compact powder iv) Liquid make up v) Stick make up vi)
Cake make up vii) Face mask viii) All purpose mask
3. Body Cosmetics:
Hand & Body lotion, Hand protective cream, Peeling lotion, Corn callus preparation, Foot cream,
Sunscreen Lotion
4. Baby Cosmetics:
Baby lotion, Baby cream, baby powder
5. Hair Preparation:
Liquid Shampoo, Cream Shampoo, Gel Shampoo, Brilliantine
6. Shaving Preparations:
i) Lather shaving cream ii) Brushes shaving cream iii) After shave powder
7. Coloured make up:
i) Lipstick ii) Lipslave iii) Pressed rouge iv) Wax based rouge v) Cake mascara vi) Cream mascara
vii) Eye shadow stick viii) Cream eye shadow ix) Liquid liner
8. Manicure Preparations:
i) Nail Lacquer ii) Nail enamel remover
9. Dental Product:
i) Mouth wash ii) tooth paste
10. Astringent and skin tonics:
Astringent stick astringent cream skin toner
11. Miscellanous:
Insectrepellant cream
BOOKS RECOMMENDED
E. Sagarin- Cosmetic Science and Technology, vol. 1-3, 2nd ed., 1974.
B. M. Mittal. Textbook of Pharmaceutical formulation.
W. A. Poucher: Perfumes, Cosmetics and Soaps Vol. I, II and III Chapman and Hall, London.
L. Lachman, H. A. Lieberman and J. L. Kaing: The Theory and practice of Industrial Pharmacy,
Vargheese Publishing House, Mumbai, 1987.
B.PHARM. V SEMESTER
Course Code Course L T Credits
PHSC 5107 Biochemistry 6 0 2
Hours Per Week
Biochemistry (Practical)
Practical: 6h/week
1. Identification of carbohydrates (Scheme and identification) (glucose, fructose, lactos, mallose,
sucrose)
2. Identification of proteins (Scheme and identification) (casein, albumin, gelatin, peptone)
3. Quantitative estimation of carbohydrates (any one method) DNA reagent, anthrone reagent
4. Quantitative estimation of proteins (any one method): biuret reagent, Lowry’s Reagent.
5. Quantitative analysis of Urine for
a) Normal Constituent
b) Abnormal constituents
6. Isolation and purification of enzymes.
BOOKS RECOMMENDED
Pharmaceutical Biochemistry, Vyas & Kohli
Laboratory Manual in Biochemistry by J. Jayaraman, New Age Int. Pvt. Ltd. New Delhi.
Comprehensive Viva and Practical Biochemistry by A.C. Deb, New Central Book Agency, Calcutta.
B.PHARM. V SEMESTER
Course Code Course L T Credits
PHSC 5108 Medicinal Chemistry I 3 0 1
Hours Per Week
BOOKS RECOMMENDED
• A.A. Siddiqui & Mohd. Ali: Practical Pharmaceutical Chemistry, New Delhi.
• Vogel’s Text Book of practical Organic Chemistry, Longman, London. New York.
• F.G. Mann & B.C. Saunders: Practical Organic Chemistry, Longman, London and New York.
B. PHARM. V SEMESTER
Course Code Course L T Credits
PHSC 5109 Pharmacology-I 3 0 1
Hours Per Week
Pharmacology-I (Practical)
Practical: 3h/week
1. Use of computer simulated CD’s or videocassettes for pharmacology practicals whenever possible.
2. Preparation of different solutions for experiments. Drug dilution, use of molar and w/v solutions in
experimental pharmacology. Common laboratory animals and anesthetics used in animal studies.
Commonly used instruments in experimental pharmacology.
3. Study of different routes of administrations in mice and rats. To study the effect of hepatic microsomal
enzymes inhibitors and induction on the pentobarbitone sleeping time in mice.
4. Effect of autonomic drugs on the gastrointestinal tract of rats or guinea pig.
BOOKS RECOMMENDED
Kulkarni S.K., Handbook of Experimentals Pharmacology, Vallabh Prakashan Delhi.
Ghosh M N., Fundamentals of Experimental Pharmacology, Scientific Book Agency, Calcutta.
Mycek M J, Gertner S Band Perper M M, Pharmacology Lippincott's Illustrated Reviews,
Lippincott Company, Philadelphia.
B.PHARM. – V SEMESTER
Course Code Course P Credits
PHSC 5110 Pharmacognosy and Phytochemistry- III 3 1
Hours per week
Practicals: 3h/week
Evaluation of drugs mentioned in theory using morphologic, microscopic and chemical methods.
Pharmacognostic study of some important drugs covered in theory.
Extraction of volatile oils and chromatographic studies.
BOOKS RECOMMENDED
1. V.E. Tyler, L.R. Brady & J.E. Robbers, Pharmacognosy (9th Edition), K.M. Varghese Company,
Bombay, India, 1988.
2. T.E. Wallis, Text Book of Pharmacognosy, J. & A. Churchill Ltd., London, 1967.
3.W.C. Evans, Trease and Evans, Pharmacognosy (14th Ed.), Gopsons Papers Limited, Noida, India, 1997.
4. Egon Stahl, Thin-Layer Chromatography, 2nd Ed., Springer Verlag, New York, 1969.
5. E.J. Shellard, Quantitative Paper and Thin Layer Chromatography, Academic Press, New York (Latest
Edition).
6. C.K. Atal & B.M. Kapur, Cultivation and Utilization of Medicinal Plants, CSIR, India, 1982.
7. J.L. Real & E. Reinhard, Natural Products as Medicinal Agents, Hippocrates Verlag Shuttgart, 1981.
8. H. Wagner, S. Bladt, E.M. Zgainski, Plant Drug Analysis, Springer-Verlag, New York, 1984.
9. Yeshajahu Pomeranz and Clifton, E. Meloan, Food Analysis : Theory and Practice, The AVI Publishing
Co. Inc., West Port, 1971.
10. Paul M. Dewick, Medicinal Natural Products: A Biosynthetic Approach, 2nd Edn. 2001, John Wiley &
Sons.
11. Practical Pharmacognosy – C. K. Kokate, A.P. Purohit and S.B. Gokhale
B.PHARM. VI SEMESTER
Planning and Decision making: Definition, importance of planning, steps involved in decision making, objectives, strategies, policies and
program.
Unit- II (09 Hrs.):
Economics: Principles of economics with special reference to the laws of demand and supply, demand schedule, demand curves, labor
welfare, general principles of insurance and inland and foreign trade, procedure of exporting and importing goods.
Accountancy: Principles of Account, ledger posting and journal entries, preparation of trial balance, columns of a cash book. Bank
reconciliation statement, rectification of errors, profit and loss account, balance sheet, purchase, keeping and pricing of stocks. Treatment
of cheques, bills of exchange, promissory notes and hundies, documentary bills.
Unit- III (09 Hrs.):
Production planning and control scientific purchasing, quality control, problems of productivity, stores organization, location of store,
receiving, inspection and issue of materials; control of stores and stocks, stores accounting and records.
Materials Management: A brief exposure or basic principles of materials management, major areas, scope, purchase, stores, inventory
control and evaluation of materials management.
Unit- IV (09 Hrs.):
Personnel Management Selection, appointment, training, transfer, promotion and demotion, remuneration, job evaluation, human relations.
Elementary knowledge of Factories Act.
Unit- V (09 Hrs.):
Pharmaceutical Marketing and market research:
a) Functions, buying, selling, transportation, storage, finance, feedback, information, channels of distribution, wholesale, retail,
departmental store, multiple shop and mail order business.
b) Measuring & Forecasting Market Demands-Major concept in demand measurement, Estimating current demand, Geodemographic
analysis, Estimating industry sales, Market share & Future demand.
c) Market Segmentation & Market Targeting.
Salesmanship Principles of sales promotion, advertising, Ethics of sales, merchandising, literature, detailing. Recruitment, training,
evaluation, compensation to the pharmacist.
Sales forecasting: Various methods, analysis, limitations and advantages.
Books Recommended
Principles of Marketing, by Philips Kottler.
Personnel management and Industrial Relations, by R.S. Davar.
Personnel management, by Mamoria.
Materials management, by Gopalkrisnan,and R.K. Rajput.
Purchasing and Store Keeping, by D.R. Gupta, R.K. Rajput.
Principles and Practice of Management - Peter Drucker.
Principles of Management - Koontz O'Donnel.
Business Organization and Management - Shukla.
Business Organization - Ghosh.
Principles of Industrial Organization - Kimball and Kimball.
Double Entry Book Keeping - Batliboi.
Professional Pharmacy - Jain and Sharma.
D.A. Whetton and K.S. Cameron, Developing Management Skills, New York: Harper Collins, 1995, 72-73.
B.PHARM. VI SEMESTER
Course Code Course L T Credits
PHSC 6102 Pharmaceutical Analysis-II4 0 4
Hours Per Week
Pharmaceutical Analysis-II (Theory)
Theory: 4h/week
Unit-I (12 Hrs.):
Theoretical consideration and application in drug analysis and quality control of following analytical techniques.
Solvent extraction methods, counter current distribution technique.
Unit-II (12 Hrs.):
Chromatography - Column chromatography: adsorption and partition theory, preparation, procedure and methods of
detection. Thin layer chromatography theoretical consideration, preparation, procedure and detection of compounds.
Paper chromatography: theory of partition, different techniques employed and different grades of papers used
qualitative and quantitative detection. Gas chromatography: introduction, fundamental of column operations and
detection. Ion exchangers: types of exchangers, mechanism of ion exchange and column operation. Counter current
extraction, ultra centrifugation and gel filtration. HPLC and HPTLC.
Unit-III (12 Hrs.):
Potentiometry - Theoretical consideration, ion selective electrode, measurement of potential, location of end point,
equipment, analytical application, direct measurements of metal concentration, differential curves, determination of
Ksp, pH measurements, dead stop titration, pH meter, pH definition, relation of pH to potential, equipment,
application.
Conductometric and hi frequency titration and their application.
Unit-IV (12 Hrs.):
Coulometric titrations - Its basic principles and application.
Non-aqueous titrations- General discussion and principle of titrations in non aqueous media, aprotic, protophilic,
protogenic and amphiprotic solvents. Titrations with perchloric acid, potassium methoxide and tetrabutyl ammonium
hydroxide.
Unit-V (12 Hrs.):
Complexometry - Principles of complexometric titrations, chelating agent, indicators, titrations with disodium
edentate.
Titrations using sodium nitrite, estimation of nitrogen content by Kjehldahl’s method, moisture content determination
by Karl-Fischer titration.
Books Recommended
Vogel’s, Text Book of Quantitative Chemical Analysis.
E. Stahl: Thin Layer Chromatography Springer, Verlag, Berlin.
HHWillard, L.L. Merritt and J.A. Dean: Instrumental Methods of Analysis, Van Nostrand Reinhold, New York.
B.PHARM. VI SEMESTER
Course Code Course L T Credits
PHSC 6103 Medicinal Chemistry-II 3 0 3
Hours Per Week
Medicinal Chemistry-II (Theory)
Theory: 3h/week
Unit-I (09 Hrs.)
1. Steroids:
a) Introduction, Nomenclature, stereochemistry, simple reactions of cholesterol, stigmasterol, ergosterol, diosgenin,
solasodine, bile acids, biosynthesis of testosterone, 17 β estradiol , aldosterone from cholesterol.
b) Estrogens - synthesis of estradiol from cholesterol and diosgenin, ethinylestradiol from estrone, nonsteroidal
estrogens, synthesis of diethylstilbesterol, SAR among estrogens, progestational agents, synthesis of progesterone
from diosgenin and stigmasterol, ethisterone ftom dehydroepiandrosterone, oral contraceptives, SAR of progestine.
c) Androgens and anabolic agents - Synthesis of testosterone from diosgenin, methyltestosterone from
dehydroepiandrosterone, methandienone from methyl testosterone, stanozolol from testosterone
d) Aderenocorticoids - glucocorticoids, mineralocorticoids, modifications in structure of hydrocortisone, SAR among
glucocorticoids.
(Hint for Unit II to V: - Chemical naming and uses of compounds official in IP/BP in all the classes will be cocered, the
folloeing topocs shall be treates covering chemical naming, structure activity relationship, physicochemical and steric aspects,
mode of action and uses, the emphasis would be mainly on BP and IP drugs, synthesis of only those drugs given in parenthesis
under each topic would be covered.)
Unit-II (09 Hrs.):
a) General anaesthetic agents: Introduction, medicinal aspects of anaesthetics, mode of action, gases and volatile liquid
anaesthetics, intravenous anaesthetics of fixed anaesthetics, toxicity of general anaesthetics (divinyl ether, ethyl
chloride, cyclopropane, thiopentone sodium, ketamine)
b) Local anaesthetic agents: Introduction, SAR, benzoic acid derivatives, aminobenzoic acid derivatives, lidocaine
derivatives, miscellaneous, toxicity, mode of action (benzocaine, procaine hydrochloride, mepivacaine, lidocaine,
cinchocaine hydrochloride)
c) Sedatives hypnotics: Introduction, classification, SAR, barbiturates, amides and imides, alcohols, and their
carbamate derivatives, aldehydes and their derivatives, mode of action, pharmacological properties and side effects
(barbitone, phenobatnitone, cyclobarbitone, pentobarbitone sodium, thiopentone sodium) non barbiturates (official
drugs),
Unit-III (09 Hrs.):
d) Anticonvulsants: Introduction, classification of epilepsy, SAR, barbiturates (official drugs), hydantoins,
oxazolidinediones, succinamides, miscellaneous dregs, phenytoin siodium, troxidone
e) Opioid analgesics: Morphine and related drugs, synthetic modifications of morphine, codeine, thebaine
f) Totally synthetic analgesics, morphinans(N methylmorphinan and 3 hydroxy N-methylmorphinan), 6,7-
benzomorphans, 4 phenylpiperidines (pethidine, methadone and isomethadone), endogenous opioid peptides, opioid
antagonists(nalorphine)
Unit-IV (09 Hrs.):
g) Antitussives: Centrally acting antitussives, opium alkaloids and their modifications, synthetic antitussives,
peripherallu acting antitussives, expectorants
h) CNS stimulants: CNS stimulants of natural origin, synthetic CNS stimulants (nikethamide, methylxanthines and
modified methylxanthines (theophylline))
i) Psychopharmacological agents: Antipsychotics, phenothiazines (chlorpromazine, trifluperazine, butyrophenones,
miscellaneous), antidepressants- TCA (amitriptyline), MAO inhibitors, atypical antidepressants, antianxiety drugs-
meprobamate and related drugs, benzodianepines (diazepam)
Unit-V (09 Hrs.):
j) Hallucinogens-hallucinogenic agents related to indoles, phenethylamines, cannabinoids.
k) Diuretics: Carbonic anhydrase inhibitors (acetazolamide and dichlorphenamide), Thiazides and related drugs
(bendrofluazide), High ceiling diuretics, aldosterone antagonists, other potassium sparing diuretics, osmotic
diuretics.
l) CVS agents: Introduction, cardiac glycosides, SAR, mechanism of action, toxic effects, antihypertensive agents-
introduction, etiology, ganglion blocking agents, antiadrenergic agents, drugs acting directly on smooth muscles,
drugs acting in CNS (propranolol), antianginals and vasodilators- introduction, mechanism of smooth muscle
vasodilatation, esters of nitrous and nitric acid, side effects(nitroglycetine), antiarryhthmic and antifibrillytic drugs
classification of antiarrhythmic drugs, mechanism of action, side effects, antilipemic drugs.
Books Recommended
Foye, W.C. “Principles of Medicinal Chemistry” Lea and Febiger, Philadelphia
Wilson and Giswold’s “Textbook of Organic, Medicinal and Pharmaceutical Chemistry” J. Lippincott Co.,
Philadelphia.
Burger’s Medicinal Chemistry, John Wiley and Sons, Newyark
Singh and Kapoor “A Text Book of Pharmaceutical and Medicinal Chemistry” Vallabh Prakashan, New Delhi.
B.PHARM. VI SEMESTER
Course Code Course L T Credits
PHSC 6104 Pharmacology-II 3 0 3
Hours Per Week
Pharmacology-II (Theory)
Theory: 3h/week
Unit-I (09 Hrs.):
Pharmacology of cardiovascular systems
a) Digitalis and cardiac glycosides.
b) Antihypertensive drugs.
c) Antianginal and vasodilator drugs, including calcium channel blockers and beta adrenergic antagonists.
d) Antiarrythmic drugs.
e) Antinyperlipidimic drugs
f) Drugs used in therapy of shock.
Unit-II (09 Hrs.):
Drugs acting on hemopoetic systems
a) Hematinics.
b) Anticoagulants, vitamin K and haemostatic agents.
c) Fibrinolyticand antiplatelet drugs.
d) Blood and plasma volume expanders.
Unit-III (09 Hrs.):
Drugs acting on urinary system
a) Fluid and electrolyte balance.
b) Diuretics.
Unit-IV (09 Hrs.):
Autacoids
a) Histamine, 5-HT and their antagonists.
b) Prostaglandins, thromboxanes and leukotrienes.
c) Pentagastrins, cholecytokinin, angiotensin, bradykinin and substance P.
Unit-V (09 Hrs.):
Drugs acting on respiratory system
a) Antiasthamatic drugs including bronchodilators.
b) Antitussive and expectorant.
c) Respiratory stimulants.
Books Recommended
Barar F S K, Text Book of Pharmacology, Interprint, New Delhi.
Best and Taylor's Physiological Basis of Medical Practice, William & Wilkins, Baltimore.
Crossland J and Thomson J H, Essentials of Pharmacology, Harper and Row Publishers NY
Craig C R and Stitzel R R, Modern Pharmacology, Little Brown and Company, 1994.
Davidson's Principles and Practice of Medicine, ELBS/Churchill Living Stone.
Di Fore Lea SH and Febiger, Atlas of Normal Histology, Philadelphia.
Ghosh MN, Fundamentals of Experimental Pharmacology, Scientific Book Agency, Calcutta.
Goodman and Gilman's, The Pharmacological basis of Therapeutics; Editors: J G Hardman,
Guyton A C, Hall JE, Textbook of Medical Physiology,WB Sannders Company.
Chatterjee C C, Human Physiology, Medical Allied Agency, Calcutta.
Shalya S, Human Physiology, CBS Publishers & Distributors.
Kulkarni SK, Handbook of Experimentals Pharmacology, Vallabh Prakashan Delhi.
Mycek MJ, Gertner SB and Perper MM, Pharmacology Lippincott's Illustrated Reviews, Lippincott Company,
Philadelphia.
Paul L, Principles of Pharmacology, Chapman and Hall.
Rang MP, Dale MM and Riter lM, Pharmacology, Churchill Livingstone.
Tortora GJ, and Anagnodokos NP, Principles of Anatomy and Physiology Harper & Row Publishers. NewYork
B.PHARM. VI SEMESTER
S. No. Course Code Course Name L* T* Credits
Pharmaceutical Manufacturing
01 PHSC 6105 4 0 4
Technology
2) Semisolid Dosage Forms: Definitions, types, mechanism of drug penetration through skin, factors
influencing penetration, semisolid bases and their selection, General formulation of semisolids,
manufacturing procedure, evaluation and packaging.
Unit – II (12 Hrs):
3) Tablets:
a) Formulation of different types of tablets, granulation methods, technology of production of granules
on large-scale by various techniques, physics of tablets making, tablets compression machinery of
different types and the equipments employed, evaluation of tablets.
b) Coating of tablets: Types of coating, film forming materials, formulation of coating solution,
equipments for coating, coating process evaluation of coated tablets.
Unit – III (12 Hrs):
4) Capsules: Advantage and disadvantages of capsule dosage form, material for production of hard gelatin
capsules, size of capsules, methods of capsule production, soft gelatin capsule shell and capsule content,
importance of base absorption and minim/gm factors in soft capsules, quality control, stability testing
and storage of capsule dosage forms.
Books Recommended
Gilbert S, Banker and Cristopher T. Rhodes - Modern Pharmaceutics Drugs and Pharmaceutical
Science Series vol. 7, 1979, M&D Inc. New York.
Lachman L, The Theory and Practice of Industrial Pharmacy, 2nd edition, Indian Edition, 1976,
K.M.Varghese Co. Bombay.
Rawlins EA, Text Book of Pharmaceutics, 8th edition, 1977, Bailliere Tindall.
Remington's Pharmaceutical Science, 1985, Mack Publishing Co., Eastern, Pa.
Carter SJ, Cooper and Gun's Tutorial Pharmacy, VI Ed., 1072, Pitman Medical.
Pharmacopoeia of India, Government of India.
British Pharmacopoeia.
Mittal BM, Textbook of Pharmaceutical Formulation, 4th Edition, Vallabh Prakashan, Delhi.
B.PHARM. VI SEMESTER
Course Code Course L T Credits
PHSC 6106 Pharmaceutical Analysis II 6 0 2
Hours Per Week
Books Recommended
Beckette and Stenlake, Practical Pharmaceutical Chemistry, Vol. I & II The Athlone Press, London
Vogel’s “ Text Book of Quantitative Chemical Analysis”
E. Stahl: Thin Layer Chromatography Springer, Verlag, Berlin.
Willard HH, Merritt LL and Dean JA: Instrumental Methods of Analysis, Van Nostrand Reinhold,
New York.
B. PHARM. VI SEMESTER
Course Code Course L T Credits
PHSC 6107 Medicinal Chemistry-II 3 0 1
Hours Per Week
Books Recommended
Vogel’s Text Book of practical Organic Chemistry, Longman, London. New York.
Mann F.G. and Saunders BC, Practical Organic Chemistry, Longman, London and New York.
Pharmacopoeia of India, Govt. of India, Ministry of Health, Delhi.
Siddiqui AA and Mohd. Ali, Practical Pharmaceutical Chemistry, New Delhi.
B. PHARM. VI SEMESTER
Course Code Course L T Credits
PHSC 6108 Pharmacology-II 3 0 1
Hours Per Week
Pharmacology-II (Practical)
Practical: 3h/week
Recording of spontaneous motor activity. Stereotype – analgesia, anticonvulsants, anti-inflammatory and
muscle relaxants activities of drug using simple experiments.
Books Recommended
Kulkarni SK, Handbook of Experimentals Pharmacology, Vallabh Prakashan Delhi.
Ghosh M N, Fundamentals of Experimental Pharmacology, Scientific Book Agency, Calcutta.
Mycek MJ, Gertner SB and Perper MM, Pharmacology Lippincott's Illustrated Reviews, Lippincott
Company, Philadelphia.
B.PHARM. VI SEMESTER
Course
S. No. Course Name P* Credits
Code
Pharmaceutical
01 PHSC 6109 6 2
Manufacturing Technology
Practicals: 6h/week
Books Recommended
Gilbert S, Banker and Cristopher T. Rhodes - Modern Pharmaceutics Drugs and Pharmaceutical
Science Series vol. 7, 1979, M&D Inc. New York.
Lachman L, The Theory and Practice of Industrial Pharmacy, 2nd edition, Indian Edition, 1976,
K.M.Varghese Co. Bombay.
Rawlins EA, Text Book of Pharmaceutics, 8th edition, 1977, Bailliere Tindall.
Remington's Pharmaceutical Science, 1985, Mack Publishing Co., Eastern, Pa.
Carter SJ, Cooper and Gun's Tutorial Pharmacy, VI Ed., 1072, Pitman Medical.
B.PHARM. VII SEMESTER (Theory & Tutorials)
Course Code Course L T Credits
PHSC 7101 Medicinal Chemistry-III 3 0 3
Hours Per Week
Medicinal Chemistry-III
Theory: 4h/week
Unit-I (09 Hrs.):
Principles of drug design: Traditional analogue, quantitative structure activity relationship (QSAR) and
mechanism based approaches. A brief introduction to graph theory, application of mechanism based
approaches. Application of quantum mechanics, computer aided drug designing (CADD) and molecular
modelling. Introduction to QSAR
Unit-II (09Hrs.):
Prodrug design
Vitamins excluding detailed study of constitution.
Metabolite antagonism-basic concepts, active site directed irreversible enzyme inhibitors, mechanism based
enzyme inhibitors, dihydrofolate synthetase inhibitors, dihydrofolate reductase inhibitors, amino acid
antagonists, antagonists directed against nucleic acids, β-lactamase inhibitors.
Urinary antiseptics quinolones, nalidixic acid, nitrofurantion
Disinfictants and antiseptics
Diagnostic agents
(Hint for Unit III to V : - The following topics shall be treated covering chemical naming, structure activity
relationship, physicochemical and stero aspects, mode of action and uses. The emphasis would be only on
BP and IP compounds. Synthesis of only those drugs given in parentheses under each topic would be
covered.)
Unit-III (09 Hrs.):
Sulphonamides, development, nomenclature and classification, antimicrobial spectrum, drug resistance,
synergism with dihydrofolate reductaste inhibitors, toxicity and side effects, reduction of crystal urea,
physicochemical properties and biological activity, protein binding and distribution, metabolism,
sulphonamides and trimethoprim combination (sulphanilamide, sulphacetamide, sulphadiazine,
sulphadimethoxine, sulphamethazole and sulphamethoxazole)
Antibiotics- classification, cycloserine, chloramphenicol, penicillins, cephalosporins, aminoglycosides,
tetracyclines, polypeptides (chloramphenicol)
Antimycobacterial agents- Introduction to mycobacterium, development of antimycobacterium agents and
their use in therapeutics (dapsone, sulfoxone sodium, solapsone, isonicotinic acid hydrazide, para
aminosalicylic acid, pyrazinamide and ethionamide)
Unit-IV (09 Hrs.):
Antimalarials: Quinoline and analogues, 8-amino quinolines, 9- amino acridines, 4- amino quinolines,
diamino pyrimidine, biguanides (primaquin, mepacrine, chloroquin , pyrimethamine)
Antiamoebic agents: Emetine hydrochloride, quinoline derivatives, metal free substances, diloxanide
furoate, metronidazole, organometallic compounds, acetarsol (diodohydroxyquinoline, diloxanide)
Drugs used for trypanosomiasis and other protozoal diseases
Anthelmintics drugs used in cestide infections, drugs used in trematode infections, drugs for intestinal
nematode infections, antifilarial agents (niclosamide , hexylresorcinol, diethylcarbamazine citrate,
thiabendazole)
BOOKS RECOMMENDED
1) Foye, W.C., Principles of Medicinal Chemistry, Lea and Febiger, Philadelphia.
2) Wolff , M.E. Ed., Burger’s Medicinal Chemistry, John Wiley and Sons, New York.
3) Hansch, C., Comprehensive Medicinal Chemistry, Pergarnon Press, Oxford.
4) Delagado, J.N. and Remers, W.A.R, Wilson and Giswold’s Text Book of Organic,Medicinal and
Pharmaceutical Chemistry, J.Lippincott Co., Philadelphia.
5) Kar, A., Medicinal Chemistry, Willey Eastern Ltd., New Delhi.
6) Patrick, G., An Introduction to Medicinal Chemistry, Scientific Distributors, Mumbai.
7) Malone, Dyson and Purey, May’s Chemistry of Synthetic Drugs.
8) Singh H.K., Kapoor, V. K., Medicinal and Pharmaceutical Chemistry, Vallabh Prakashan, New Delhi
9) Thomas, G., Introduction to Medicinal Chemistry, CBS Publishers and Distributors, New Delhi.
B.PHARM. VII SEMESTER (Theory & Tutorials)
Course Code Course L T Credits
PHSC 7102 Pharmaceutical Analysis III 4 0 4
Hours Per Week
Pharmaceutical Analysis III
Theory: 4h/week
Unit-I (12 Hrs.):
Electromagnetic radiations – Nature of electromagnetic radiations, the interaction between energy and
matter, applications of quatum mechanics theory, the absorption of energy by atoms and molecules, the
emission of radiant energy by atom and molecules: refraction and diffraction
Ultraviolet and Visible spectrophotometry- Electronic excitation, quantitative laws, deviation from beers
law, graphical presentation of data, chromophores, photometric errors, instrumentation (light sources,
prism, & grating, monochromators, photoemissive & photomultipliers tubes), single& double beam
instruments, steps in spectrophotometric measurements (sample handling; amplification and radiation of
detectors, selection of wavelengths & bandwidth), concentration and optimum absorbance value,
applications (direct & indirect methods, analysis of mixture).
X Ray-spectrometry - An introduction to the theory of X ray spectroscopy [miller, space lattice and unit
cell, bravais lattices]. Interplaner spacing in crystal system. Diffraction of X -ray by crystal, bracgg
equation, powder method, x- ray diffraction pattern of cubic system [NaCl], application on
pharmaceutical analysis.
BOOKS RECOMMENDED
1) Svehla, G. Vogel’s Text Book of Micro and Semi Micro Qualitative Inorganic Analysis, Orient
Longman, Hyderabad.
2) Beckett, A.H. and Stenlake, J.B., Practical Pharmaceutical Chemistry, The Athlone Press of the
University of London.
3) Chatten, L.G., Text Book of Pharmaceutical Chemistry, Marcel Dekker, New York.
4) Connors, K,.A., A Text Book of Pharmaceutical Analysis, Wiley Interscience, New York.
5) Higuchi, J. and Hansen E.B., Pharmaceutical Analysis, Interscience Publisher, John Willey and Sons,
New York, Sydney.
6) Silverstein,R.M., Bassier, G.C., and Morril,T.C., Spectrophotometric Identification of Organic
Compounds, John Wiley and Sons Inc.
7) Willard, Merritt and Settle, Instrumental Methods of Chemical Analysis,CBS
Publisher and Distributors, New Delhi.
8) Ewing, G.W., Instrumental Methods of Chemical Analysis.
B.PHARM. VII SEMESTER (Theory & Tutorials)
Course Code Course L T Credits
PHSC 7103 Pharmacology-III 3 0 3
Hours Per Week
Pharmacology-III
Theory: 3h/week
Unit-I (09 Hrs.):
Drugs acting on the Gastrointestinal Tract
Antacids, antisecretory and anti-ulcers drugs
Laxatives and antidiarrhoeal drugs
Appetite stimulants and suppressants
Emetics and anti-emetics
Unit-II (09 Hrs.):
Pharmacolgy of Endocrine system.
Hypothalamic and pituitary hormones.
Thyroid hormones and anti thyroid drugs, parathormone, calcitonin and vitamin D.
Insulin, oral hypoglycaemic agents and glucagons.
ACTH and corticosteroids.
BOOKS RECOMMENDED
1) Barar F S K, Text Book of Pharmacology, Interprint, New Delhi.
2) Best and Taylor's Physiological Basis of Medical Practice, William & Wilkins, Baltimore.
3) Crossland J and Thomson J H., Essentials of Pharmacology, Harper and Row Publishers, NewYork
4) Craig C R and Stitzel R R, Modern Pharmacology, Little Brown and Company, 1994.
5) Goodman and Gilman's, The Pharmacological basis of Therapeutics; Editors: J G Hardman, L E
6) Guyton A C, Hall JE., Textbook of Medical Physiology,WB Sannders Company.
7) Mycek M J, Gertner S Band Perper M M, Pharmacology Lippincott's Illustrated Reviews, Lippincott
Company, Philadelphia.
8) Paul L., Principles of Pharmacology, Chapman and Hall.
9) Rang MP, Dale MM, Riter lM., Pharmacology, Churchill Livingstone.
10) Tortora G J, and Anagnodokos N P, Principles of Anatomy and Physiology Harper & Row Publishers N.
Y.
B.PHARM. VII SEMESTER (Theory & Tutorials)
Course
S. No. Course Name L* T* Credits
Code
Drug Legislation and
01 PHSC 7104 4 0 4
Regulatory Affairs
Course
Course Name P* Credits
Code
PHSC 7106 Medicinal Chemistry III 3 1
BOOKS RECOMMENDED
1) Vogel’s Text Book of practical Organic Chemistry, Longman, London. New York.
2) Mann F.G. and Saunders BC, Practical Organic Chemistry, Longman, London and New York.
3) Pharmacopoeia of India, Govt. of India, Ministry of Health, Delhi.
4) Siddiqui AA and Mohd. Ali, Practical Pharmaceutical Chemistry, New Delhi.
B.PHARM. VII SEMESTER (Practicals)
Course
Course Name P* Credits
Code
PHSC 7107 Pharmaceutical Analysis III 3 1
BOOKS RECOMMENDED
1) Pharmacopoeia of India, Govt. of India, Ministry of Health, Delhi.
2) Vogel’s Text Book of Micro and Semi Micro Qualitative Inorganic Analysis, Orient Longman,
Hyderabad.
3) Beckett, A.H. and Stenlake, J.B., Practical Pharmaceutical Chemistry, The Athlone Press of the
University of London.
B. PHARM. VII SEMESTER (Practicals)
Course
Course Name P* Credits
Code
PHSC 7108 Pharmacology III 6 2
Pharmacology III
Practical: 3h/week
1. Experiments on isolated preparations: To estimate the strength of the test sample of agonist/ drug
(e.g. acetylcholine, histamine, 5- HT, oxytocin, etc.) using a suitable isolated muscle preparation
employing matching bioassay, bracketing assay, three point assay and four point assay.
2. Pharmacology of Gastrointestinal Tract: To study the anti-ulcer and anti-secretary activity using
pylorus ligated rats.
BOOKS RECOMMENDED
1) Kulkarni S.K., Handbook of Experimentals Pharmacology, Vallabh Prakashan Delhi.
2) Ghosh M N., Fundamentals of Experimental Pharmacology, Scientific Book Agency, Calcutta.
3) Mycek M J, Gertner S Band Perper M M, Pharmacology Lippincott's Illustrated Reviews, Lippincott
Company, Philadelphia.
B.PHARM. VII SEMESTER (Practicals)
Course Code Course Name P* Credits
Practical: 3h/week
BOOKS RECOMMENDED
Course
Course Name L* T* Credits
Code
Novel and Controlled Drug
PHSC 8101 4 0 4
Delivery Systems
Theory: 4h/week
Unit-I (12 Hrs.):
Concepts and systems designed for rate controlled drug delivery. Mechanism of the drug release from
matrix systems and reservoir systems.
Carrier/ vesicular based drug delivery systems i.e. Liposomes, niosomes, elastosomes, pharmacosomes.
BOOKS RECOMMENDED
1. Robinson, J.R. & Lee, V.H.I.,: Controlled and Novel Drug Delivery Marcel Dekker, New York and
Basel.
2. Jain, N.K.: Controlled and Novel Drug Delivery, CBS, New Delhi.
3. Jain, N.K. Advances in Novel and Controlled Drug Delivery.
4. Chien, Y.W.: Novel Drug Delivery Systems, Marcel Dekker, New York and Basel.
5. Roseman, T.J.: Controlled Release Drug Delivery Ssytems, Marcel Dekker New York
6. Goldberg : Targeted Drugs.
7. Bruck, S.D., Controlled Drug Delivery, Vol. I & II.
8. Juliano, R.L. Drug Delivery Systems.
9. Review articles published in various journals.
B.PHARM. VIII SEMESTER (Theory & Tutorials)
Course
Course Name L* T* Credits
Code
Biopharmaceutics &
PHSC 8102 4 0 4
Pharmacokinetics
2) Passage of drug across GIT membrane. Mechanism, physico-chemical, biological and pharmaceutical factors
affecting drug absorption through GIT- Physicochemical, biological and dosage from related factors. Techniques
for the GIT absorption assessment.
Unit – II (12 Hrs):
3) Drug disposition: Distribution in blood, plasma -protein binding, application of drug protein binding.
7) Two compartment open model with first order elimination kinetics, pharmacokinetics of single and multiple dose
administration, as applied to intravenous (rapid/bolus) and oral administration intravenous infusion,
pharmacokinetic basis of sustained release formulations.
Unit – IV (12 Hrs):
8) Absorption kinetics: Curve Fitting, Wagner-Nelson, Loo Riegelman methods and Deconvolution methods for
estimation of absorption rate constants.
9) Dosage regimen: Dosage regimen adjustment in patients with and without renal failure.
Unit – V (12 Hrs):
10) Non-Compartmental Analysis: Statistical moments, Application, bioavailability determination.
BOOKS RECOMMENDED
1. Handbook of Basic Pharmacokinetics-Ritschel, W.A.,Drug Intelligence Publication, M Hamilton, 1977.
2. Fundamentals of Clinical Pharmacokinetics-Wagner,J.C.,Drug Intelligence Publication, M.Hamilton, 1975.
3. Remington's Pharmaceutical Sciences - Gennaro A.R., ed., 19th Edition, Mack Publishing Co., Easton, PA.
1995.
4. Clinical Pharmacokinetics - Rowland, M. & Tozer,N., 2nd,edition, Lea and Febiger, Philadelphia, 1989.
5. Pharmacokinetics-Gibaldi M. & Perrier, D., 2nd ed., Marcel Dekker, New York, 1982.
6. Pharmacokinetics for the Pharmaceutical Scientist-Wagner, J.C., Technomic Publishing AG, Switzerland,
1993.
7. Biopharmaceutics and Pharmacokinetics-Notari, R.E., 2nd ed., Marcel Dekker, New York, 1975.
B.PHARM. VIII SEMESTER (Theory & Tutorials)
Course
Course Name L* T* Credits
Code
Pharmacognosy and
PHSC 8103 3 0 3
Phytochemistry -IV
Pharmacognosy and Phytochemistry -IV
Theory: 3h/week
Unit-I (9 Hrs.):
Study of indigenous traditional and emerging drugs with their source (includind alternative/
controversial) medicinal uses, pharmacological action/activity, chemical profile and authentication of
following:
Amla (Phyllanthus emblica), Harad (Myroblan-Treminalia chebula), Baheda (Terminalia belerca),
Guduchi (Tinospora cardifolia), Kalmegh (Andrographis paniculata), Guggal (Commiphora weightii),
Salai (boswellia serrata), Brahmi (Centell asiatica), Shankhpuspi (Convolvulus microphyllus), Bach
(Acorus calamus), Kantkari (Solanum xanthocarpum), Tulsi (Ocimum sanctum), Valerian (Valerian
wallchi), Jatamansi (Nardostacys jatamansi), Gokhru (Tribulus terrestris), Arjuna (Terminalia arjuna),
Unit-II (9 Hrs.):
Ashok – (Saraca indica), Vidang (Embelia ribes), Lahsun (Garlic-Allium sativum), Malkangni
(Celastrus paniculata), Bhilwa (Semecarpus anacadium), Chirayata (Swertia chirata), Neem
(Azadirachta indica), satavar (Aspargus racemosus), Safed Musli (Chlorophytum borivalianum),
Artemisia (Artemica spp), Thylophora (Thylophora indica), Morinda (Morinda citrifolia), Chitrak
(Plumbago zeylanicum), Haldi (Curcuma domestica), Tephrosia (Tephrosia purpurea), Bhui Amla (
Phyllanthus amarus), Shilajeet
Unit-III (9 Hrs.):
Introduction to dosage forms in Indian system od medicine with preparation and standardization of some
important dosage forms such as Asavas Arishtas, Avalehas and Churnas.
Unit-IV (9 Hrs.):
General method of extraction, isolation, identification and characterization of Phytoconstitutents of
Carbohydrates, Alkaloids Glycosides and Phenolic and Steroidal groups.
Unit-V (9 Hrs.):
An introduction to Tissue culture techniques with their scope as alternative sourse of Phyto-
Pharmaceuticals.
An overview of plants as sourse of Bitters, Sweeteners, Colours, Flavoures, Carotinoids, Photosenstizing
agents and Vaccines
BOOKS RECOMMENDED
1. Trease, G.E. and Evans, W.C., Pharmacognosy, Bailliere Tindall, Eastbourne, U.K.
2. Tayler, V.C., Brady, L.R. and Robers, J.E., Pharmacognosy, Lea and Febiger, Philadelphia.
3. Shah, C.S. and Quadry, J.S., A text book of Pharmacognosy, B.S. Shah Publishers,
Ahmedabad.
4. Kokate, C.K., Purohit, A.P. and Gokhale, S.B., Pharmacognosy, Nirali Prakashan, Pune.
5. Indian Pharmacopoeia, Ministry of Health and Family Welfare, Govt. of India, New Delhi.
6. Wallis, T.E., Text Book of Pharmacognosy, Jand A Churchill Limited, London
B.PHARM. VIII SEMESTER (Theory & Tutorials)
Course
Course Name L* T* Credits
Code
PHSC 8104 Elective 4 0 4
Theory: 4h/week
List of Elective Subjects:
I. GMP, Quality Assurance and Validation
II. Packaging Technology
III. Drug Design
IV. Drug Interaction
V. Nutraceuticals
VI. Herbal Drug Technology
Course
Course Name P* Credits
Code
Novel and Controlled Drug
PHSC 8105 3 1
Delivery Systems
Practical: 3h/week
BOOKS RECOMMENDED
1) Robinson, J.R. & Lee, V.H.I.: Controlled and Novel Drug Delivery Marcel Dekker, New York and
Basel.
2) Jain, N.K.: Controlled and Novel Drug Delivery,CBS, New Delhi.
3) Jain, N.K. Advances in Novel and Controlled Drug Delivery.
4) Chien, Y.W.: Novel Drug Delivery Systems, Marcel Dekker, New York and Basel.
5) Roseman, T.J.: Controlled Release Drug Delivery Ssytems, Marcel Dekker New, York
6) Goldberg : Targeted Drugs.
7) Bruck, S.D., Controlled Drug Delivery, Vol. I & II.
8) Juliano, R.L.: Drug Delivery Systems.
B.PHARM. VIII SEMESTER
Course
Course Name P* Credits
Code
Biopharmaceutics &
PHSC 8106 3 1
Pharmacokinetics
Practical: 3h/week
Practicals based on ADME process, bioavailability, bioequivalance, protein binding, compartment models,
Non-linear pharmacokinetic analysis.
BOOKS RECOMMENDED
1. Handbook of Basic Pharmacokinetics-Ritschel, W.A. Drug Intelligence Publication, M Hamilton, 1977.
2. Fundamentals of Clinical Pharmacokinetics- Wagner, J.C., Drug Intelligence Publication, M. Hamilton,
1975.
3. Remington's Pharmaceutical Sciences - Gennaro A.R., ed., 19th Edition, Mack Publishing Co., Easton,
PA. 1995.
4. Clinical Pharmacokinetics - Rowland, M. & Tozer,N., 2nd,edition, Lea and Febiger, Philadelphia, 1989.
5. Pharmacokinetics-Gibaldi M. & Perrier, D., 2nd ed., Marcel Dekker, New York, 1982.
6. Pharmacokinetics for the Pharmaceutical Scientist-Wagner, J.C., Technomic Publishing AG,
Switzerland, 1993.
7. Biopharmaceutics and Pharmacokinetics-Notari, R.E., 2nd ed., Marcel Dekker, New York, 1975.
B.PHARM. VIII SEMESTER (Practicals)
Course
Course Name P* Credits
Code
Pharmacognosy and
PHSC 8107 3 1
Phytochemistry -IV
Practical: 3h/week
1. Identification of drugs mentioned in theory (PHSC-8103) with microscopy of underlined drugs in entire
and powderded form.
2. Chemical evaluations of following through extractive values: Harad, Baheda, Amla, Kalmegh and Bach
3. Chromatographic evaluations of following: Harad, Baheda, Guduchi, Amla, Kalmegh, Guggul
4. Pharacognostic study of at least one commonly marketed herbal product
5. Excursion of Medicinal Plant Garden
BOOKS RECOMMENDED
Course
Course Name P* Credits
Code
PHSC 8108 Project on elective 6 2
B.PHARM. – III SEMESTER
Course Course L T Credits
Code
PHARMACOGNOSY AND
PHSC 3105 4 0 4
PHYTOCHEMISTRY-II
Hours Per Week
BOOKS RECOMMENDED
1. Pharmacognosy: Trease and Evans
2. Pharmacognosy: Tyler and Brady
3. Pharmacognosy – C. K. Kokate, A.P. Purohit and S.B. Gokhale
4. A Text Book of Pharmacognosy – C.S. Shah & J. S. Quadry
5. A Text Book of Pharmacognosy – T. E. Wallis
6. Text Book of Pharmacognosy – V. K. Kapoor & S.S. Handa
7. Pharmacopoeia of India.
B.PHARM. –V SEMESTER
Course Code Course L T Credits
Pharmacognosy and Phytochemistry-
PHSC 5105 3 0 3
III
Hours Per Week
Pharmacognosy and Phytochemistry-III
Theory: 3h/week
Unit-I (9 Hrs.)
Systematic Study of Crude Drugs: Including synonyms, biological / geographical sources, identification, chemical
constituents, chemical tests, uses, adulteration and evaluation of glycosidal drugs of following groups:
Anthraquinone glycosidal drugs: Senna, Aloe, Rhubarb, Cascara etc.
Saponin glycosidal drugs: especially, Dioscorea, Solanum, Licorice, Senega, Ginseng.
Cyanogenetic glycosidal drugs: Wild Cherry.
Coumarins and Furanocoumarin glycosidal drugs including Psoralea.
Miscellaneous glycosidal drugs: Gentian, Quassia, and Saffron etc.
Unit-II (9 Hrs.)
Systematic Study of Crude Drugs: Including synonyms, biological / geographical sources, identification, chemical
constituents, chemical tests, uses, adulteration and evaluation of Alkaloidal drugs of following groups:
Indole alkaloidal drugs : especially Ergot, Nux-vomica, Rauwolfia, Catharanthus.
Isoquinoline alkaloidal drugs: including Ipecac, Opium, Curare.
Tropane alkaloidal drugs: Stramonium, Hyoscyamus, Datura, Belladonna, Duboisia etc.
Quinoline alkaloidal drugs: including Cinchona.
Pyridine alkaloidal drugs: especially Areca, Lobelia, Nicotiana.
Imidazole alkaloidal drugs: including Pilocarpus.
Quinazoline alkaloidal drugs: including Vasaka.
Steroidal alkaloidal drugs: especially Ashwagandha, Kurchi, Veratrum, Solanum.
Proto-alkaloidal drugs: Ephedra, Colchicum etc.
Terpenoid alkaloidal drugs: including Aconite.
Unit-III (9 Hrs.)
Phytochemical Screening:
Preparation of extracts, Phytochemical tests for detection of common plant constituents, Biosynthetic pathways for secondary
plant constituents, General principles of formation of primary and secondary plant metabolites. Biogenesis of medicinally
important glycosides, alkaloids, carbohydrates, lipids, volatile oils and steroids.
Unit-IV (9 Hrs.)
Utilization and production of phytoconstituents from aromatic and medicinal plants: Isolation of the following phyto-
constituents (including industrial methods):
Morphine, Quinine, Reserpine, Sennosides, Digitalis glycosides, Diosgenin, Menthol, Thymol, Rutin, Psoralen.
Unit-V (9 Hrs.)
Classification and general treatment of alkaloids and glycosides of different categories including methods of isolations physico
chemical properties and chemical tests for identification.
Books Recommended:
1. Pharmacognosy: Trease and Evans
2. Pharmacognosy: Tyler and Brady
3. Pharmacognosy – C. K. Kokate, A.P. Purohit and S.B. Gokhale
4. A Text Book of Pharmacognosy – C.S. Shah & J. S. Quadry
5. A Text Book of Pharmacognosy – T. E. Wallis
6. Text Book of Pharmacognosy – V. K. Kapoor & S.S. Handa
7. Pharmacopia of India