Applied Biopharmacy Exercises by Mte

College of Medicine and Health Sciences
School of Medicine and Pharmacy

Department of Pharmacy/ BY MT-Einstein PHARM4; 2018-19
APPLIED BIOPHARMACY
A4.what are pharmacokinetics conditions to consider in providing replacement dose
for patients under dialysis
A4.1.the following is true on the patient under hypoproteinemia

a) The free fraction of drug is increased
b) The volume of distributions is decreased
c) The blood concentration of the drug is increased
d) Modification of the dose is justified in uremic patient
e) Only a and d are correct
A4.2. T/F For drugs having a small coefficient of extraction or a small plasma
protein binding, the clearance depends on the capacity of renal metabolism
A3. List the Pharmacokinetics parameters to consider in formulating controlled

releases
A1. Explain the following terms using the related formulae

a) Absolute bioavailability
b) Relative bioavailability
c) Comparative bioavailability
d) Zero order kinetics
e) First order kinetics
A1.1 what are the factor to consider in pk for adjusting patient dose according to
pathophysiology
A1.2. what are the objectives of biopharmaceutics

A1.3 what are the physico-chemical factors that influence drug bioavailability
A1.4 what are the physicochemical and physiological parameter that influence
drug dissolution
A1.5What are the Factors associated with the formulation of aqueous solutions that
can influence drug bioavailability
Q. T/F Usually, the absorption of a drug in suspensions dosage form is dissolution-

rate limited
A1.4 what are factors associated with the formulation of emulsions that can
influence drug bioavailability
A12L. What are the factors associated with the formulation of suspensions can
influences drug bioavailability
A05. What are the Factors associated with the formulation of liquid-filled gelatin
capsules that can influence drug bioavailability
A23. Enumerate the 4 step of the drug release from the tablet
AH34. Complete the table by yes or no, according to the formulation and stage
pass through for the process of the drug release
Q017. Why do tablet are coated

Q34M. What influence the rate of drug release from coated tablet?
Qw34.Mentions why do we need the enteric-coated tablet formulations

Lm12. Enumerate at least two enteric coating agents
Qw345.What are the properties to quantify in assessing the biopharmaceutical

propertis of medicines relating to absorption.
Qw76. What are the factors influencing the dissoluation rate and bioavailability of
the conventional tablet.
89. When designing a dissolution test to assess drug release by the beak method,
the following are true except
a) Beaker contain the 400 cc
b) The dissolution medium is 300cc
c) agitated by three bladed polyethylene stirrer with a diameter of 50 mm
d) The stirrer is immersed to a depth of 27 mm into the dissolution medium
e) Polyethylene stirrer is rotated at 60 rpm
67MT. Apart from the beaker, method what are other method used to assess the
dissolutions of medicines in vitro
PT5. State the medium you should need to access the drug release in stomach at
fasted state
TM34. Describe the assessment of drug quality according to

a) drug from dosage form into solution
b) stability in physiological fluid
c) transport across biological membrane
d) resistance to first pass metabolism
MT23. How can you prepare the medium for testing dissolution of drug in the
intestines according to dressman et al in 1998?
A2. How can you access the drug stability in physiological fluid?
A235. How can assess the drug efficiency in permeability capacity

657THE. Describe the at least six modes used in accessing drug permeability
across biological membrane.
QRT100. Briefly, describe how the permeability by cell culture (caco-2-

monolayers) is conducted.
GRM56. Discuss about the assessment of drug permeability by

a) Cell culture
b) Perfusion studies
BGH67. Define the following terms

a) chemical equivalence
b) pharmaceutical equivalence
c) pharmacological equivalence
d) therapeutic equivalence
e) bioequivalence
TY980. What is indications of bioavailability, absolute, relative and

comparative bioavailability?
Q123M. What are the advantages and disadvantages of modified release

dosage form?
What are the different form of modified release, drop out the kinetic release profile?
QM34. Enumerate the following modified release dosage form and give example for each
B A C D E
DT56. Describe the Criteria required to consider about

formulating a Controlled Release form
QWER123. What are the parameters to take in account while choosing

drug to be formulated as the modified releases medicines?
YT678. Enumerate different formulation methods of achieving

modified drug release
Q124. Define the following terms or differentiate the following

1. Delivery systems with Discontinued kinetics and with
Continued kinetics
2. Lenticures and spacetabs
3. Spansules and Medules
4. Double layer tablet
Qt  f i Q0  f s Q0 1  e
Da of continuous
  k0 t
Dm of continuous kinetics

kinetics
CELL CULTURE: CACO2MONOLAYER
Da
Vd 
CE
Da  CE  Vd
Dm  CE  Vd  T  ke
Dm  Da  T  ke
CE  Vd  T  0.693
Dm 
t 12
Calculation of doses being incorporated in each unit

TM 45. List different available modified release forms of

which the kinetics of release is continuous. And describe
the drug kinetic release mechanisms
TM 46. List different available modified release forms of

which the kinetics of release is discontinuous and describe
the drug kinetic release mechanisms
Review exercise
1. Give the difference between First order kinetics and Zero order kinetics
2. Describe the basket method for dissolution test in vitro
3. List different available modified release forms of which the kinetics of release is continuous
4. Define the criteria to consider before deciding to make dosing correction after dialysis
5. Describe the Mathematical modelings in pharmacokinetics
6. Why biopharmacy course
7. Describe the mechanism of drug realease from coated tablet
8. Describe how do we assess biovailablity (use one method for single step)
9. Describe the dissolution medium of drug in feed stage of intestine medium
10. Give the difference between First order kinetics and Zero order kinetics
11. Describe the basket method for dissolution test in vitro
12. List different available modified release forms of which the kinetics of release is continuous
14. What do you understand when saying “Alcohol is eliminated by zero-order kinetics?
15. List different available modified release forms of which the kinetics of release is discontinued
17. Give the difference between Physiological model and Compartmental model
18. State the steps involved during drug release of coated tablets
19. List different methods used to test bioavailability in vitro
20. In modified release forms show how to calculate loading and maintenance
22. List the formulation with continuous kinetic drug releases
23. Describe the dissolution drug medium in fasted state of stomach medium
24. Describe the cell culture by coco2monolayer in assessing the drug permeability

Applied Biopharmacy Exercises by Mte

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Applied Biopharmacy Exercises by Mte

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College of Medicine and Health Sciences

School of Medicine and Pharmacy

A4.1.the following is true on the patient under hypoproteinemia

A3. List the Pharmacokinetics parameters to consider in formulating controlled

A1. Explain the following terms using the related formulae

A1.2. what are the objectives of biopharmaceutics

Q. T/F Usually, the absorption of a drug in suspensions dosage form is dissolution-

Q017. Why do tablet are coated

Qw34.Mentions why do we need the enteric-coated tablet formulations

Qw345.What are the properties to quantify in assessing the biopharmaceutical

TM34. Describe the assessment of drug quality according to

A235. How can assess the drug efficiency in permeability capacity

QRT100. Briefly, describe how the permeability by cell culture (caco-2-

GRM56. Discuss about the assessment of drug permeability by

BGH67. Define the following terms

TY980. What is indications of bioavailability, absolute, relative and

Q123M. What are the advantages and disadvantages of modified release

DT56. Describe the Criteria required to consider about

QWER123. What are the parameters to take in account while choosing

YT678. Enumerate different formulation methods of achieving

Q124. Define the following terms or differentiate the following

CELL CULTURE: CACO2MONOLAYER

Calculation of doses being incorporated in each unit

TM 45. List different available modified release forms of

TM 46. List different available modified release forms of

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