ANDENEX-CHEMIE —— fngelhard +Partner. GmbH, Andenex-Chemi Alberts Ring 1k 22761 HH OXIALFARM CIA LTDA. RUC 1792385202001 De los Fundadores E2-03 Elias Godoy Sector Carapungo Pichincha Quito ECUADOR OFERTA NO.: 20799 Centfied to 180 9001:2008 Albert-Einstein-Ring 11 D-22761 Hamburg, Germany Tels (0 40) 89 96 79-01 Fax: (040) 89 96 79-12 info@andenex.de Ust-ldNe DEI18529614 Hamburg, 27.06.2018 ‘Agradecemos su demanda y tenemos el placer de cotizar - sujeto a nuestra confirmacion final si no se indica lo contrario - como sigue: Producto Cantidad IBUPROFENO 5,000 KG USP 40 - 70 GRADE INDIA 50 kg tambores tiempo de transito del buque de aprox 60 dias despues salida del puerto de Mumbai /India Precio USD 24,901 KG Incoterms CFR Guayaquil via maritimo desde India Tiempo de Entrega Septiembre 2018 desde India - sujeto recibo la OIC inmediatamente Pago 120 dias fecha factura Nota Despachos | 2500 kg maritimo 2500 kg aereo desde India calidad segun copia modelo anexado Precio CPT Quito aereo USD 30,40 KG. NOTA IMPORTANTE Los precios solo tienen validez sujeto recibo la OIC para un total de 5000 kg neto ANDENEX-CHEMIE Engelhard + Partner GmbH Amisgericht Hamburg HRB:25784 - Geschafifubrer: Wolfang Engsthard& IOL CHEMICALS AND PHARMACEUTICALS LTD FE ANALYSIS att Product Name : IBUPROFEN USP 7°79 HBidietD No? 4900/1201/18/A-0163M Date of Mfg. Apr. - 2018 Date of Analysis : 11/04/2018 Date of Expiry : Mar - 2023 AR No. 4000/1151/0418/A-0163M/2906 Drug Lic. No. : 1689-OSP Batch Qty 1000 Kg Dispatch Qty : 1000 Kg Packing 20X50 Kg S.NO TEST SPECIFICATIONS RESULTS T Deseription White to off white erysaline powder | Whit erystalline powder having slight characteristic odor. z Solubiiy Very soluble in alcohol, n methanolin | Complies acetone, and in ehloroformslight!y soluble in ethyl acetate,practically insoluble in water. 3 TMentifieation A)By IR The infra-red absorbance spectrum | Complies cobiained from the sample should be concordant with spectrum obtained from the standard B)By UV Respective absorptivities at 264 nm | Abs. 273 = 0.43% and 273 nm, calculate on the ‘Abs. 264 = 0.29% anhydrous basis. Do not differ by more than 3.0%. ) The chromatogram of the assay | Complies preparation obtained by as directed in the assay exhibits a major peak for ibuprofen, the retention time of which, relative to that ofthe intemal standard, corresponds to that exhibited in the chromatogram of the standard preparation, obtained as directed inthe 7 ‘Water ContentGwhw) <10% TO Residue on Ignition win) [$0.5 % 0.02% Page 1/2 Head Office: 85, Industrial Area “A”, Ludhiana — 141 003 (Pb.) India Ph: + 91-161-2225531 — 35, Fax: + 91-161-2608784 Regd. Office: Trident Complex, Sanghera, Barnala— 148 101 (Pb.) In Works:Trident Complex, Mansa Roe Fepeesh TE Barnala-148101 (Pb.) Ph, : +91-1679-285285-88 , Fax : +91- “ABTA RRS297 IOL CHEMICALS 4 got iD. PHARMACEUTICALS LTD OH E ENE CERTIF \NALYSIS 57 Hamburg Product Name © IBUPROFEN USP Batch No. 4000/1201/18/A-0163M. Date of Mfg. Apr. - 2018 Date of Analysis : 11/04/2018 Date of Expiry : Mar - 2023 A.R No. 4000/1151/0418/A-0163M/2906 Drug Lic. No. : 1689-OSP Batch Qty 1000 Kg Dispatch Qty : 1000 Kg Packing 20X S0Kg S.NO TEST SPECIFICATIONS: RESULTS G Related Sabanses Oy HPLC ilmpuciy + 50.15% 0.05% iiSingle Largest unknown | <0.1% 0.03% timpunty iifotal unknown Impurity | 50.3% 008% iv Total Impuciy 510% 0.13% 7. Timit of Ibuprofen Related | <0.1% BQE Comp C z Assay (On Aaiyarous | S70 TOR0% wa ass) 3 Residual Solves i)Acetone 5 100 ppm BDL ii) Hexane $100 ppm 43 ppm iip'Taehlor ethylene |S 80 ppm Not Detected iv) sopropy! Alcohol £100 pa Not Detected +) Benzene eae Not Detected# ADDITIONAL TESTS i TyBulk Density ‘)Linapped Density 025-050 gil 0.43 gi biTapped Density 040-065 pind 0.53 gil z Parle size = 35 miswons microns T Benzene 1s not sed in manutacuring prosess ‘impurity J: QRS)-2-[4-2-methyl propanoy!)-phenyl] propanoie acid "The above material complies as Per USP 40. a B5 “s Prepared By Checked By Approved By K Kumar Jj Singh R.P.Verma Executive QC Dy.Manager QC Sr Manager QC Released By Navnath Nimbalkar Sr Manager QA Page 2/2 Head Office: 85, Indus 1 Area “A”, Ludhiana — 141 003 (Pb.) India Ph: + 91-161-2225531 — 35, Fax: + 91-161-2608784 Regd. Office: Trident Complex, Sanghera, Barnala ~ 148 101 (Pb.) India Works:Trident Complex, » \d, Vill Fatehgarh Channa, Barnala-148101 (Pb.) rae Fan ‘| Ph. : +91AR679-288: 1-1679-285292 se partner Gm! Engelhard +