ABSTRACT
Regulatory T lymphocytes can suppress immune response, affecting the control of infection and
consequently healing. The structure of the immune system is based on the innate and adaptive
responses. The activation of the adaptive immune response is dependent on lymphocytes and their
soluble molecules. Immune response mediated by cells, specificity and diversity of recognition, memory,
self-limitation and autoimmune tolerance are the main features associated to adaptative immune
response. This article relates studies suggest the involvement of regulatory T cells with the healing
process. A bibliographic review which analyzed various scientific articles related to immune response
and wound healing was performed. Our work shows the importance of regulatory T lymphocytes in
finalizing the inflammatory process by inducing the suppression of cytotoxic T lymphocytes (CD8
+). Acting together with the Treg cells, TGF-β limits the inflammatory and start the healing process.
Another growth factor in wound healing PDGF is the process which has function of attracting
monocytes and neutrophils and promote the synthesis of collagen and proteoglycans. PDGF is a
major growth factor of importance in the proliferation and activation of fibroblasts, promoting wound
contraction. The T lymphocyte indirectly acts as a modulator of interstitial fibroblasts, contributing
to fibrogenesis through substances produced by it. Such substances will act in causing effects such
as fibroblast proliferation and secretion of fibronectin and collagen, being considered the "healing
hormone", causing the formation of the extracellular matrix as well as wound contraction. Although
there is no direct relationship of T lymphocytes in healing, it was revealed its influence, especially
from the TGF-β, the most influential factor in fibrogenesis.
INTRODUÇÃO
MÉTODOS
lesions. 2008;26(3):351–6.
25. Robson MC, Phillip LG, Cooper DM, Lyle
WG, Robson LE, Odom L, et al. Safety and CONSIDERAÇÕES FINAIS
effect of transforming growth factor-beta(2)
for treatment of venous stasis ulcers. Wound
Repair Regen [Internet]. Jan [cited 2015 Apr
9];3(2):157–67. Available from: http://www. Uma vez que a cicatrização é um processo consequente á
ncbi.nlm.nih.gov/pubmed/17173644
inflamação, buscamos relaciona-la com as células do sistema imune,
em especial os linfócitos T reguladores, que apesar de serem essenciais
para aregulação da resposta imunológica, podem tornar-se prejudiciais
ao organismo quando se encontram em falta ou em excesso.
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