DATE: June 8, 1988 ARMY CHEMICAL Emergency Telephone #s: RESEARCH, DEVELOPMENT CRDEC Safety Office AND ENGINEERING CENTER 301%671-4411 0800-1600 EST After normal duty hours: 301-278-5201 Ask for CRDEC Staff Duty Officer MATERIAL SAFETY DATA SHEET SECTION I - GENERAL INFORMATION Department of the Army MANUFACTURER'S ADDRESS: U.S. ARMY ARMAMENT, MUNITIONS AND CHEMICAL COMMAND CHEMICAL RESEARCH DEVELOPMENT AND ENGINEERING CENTER ATTN: SMCCR-SFS ABERDEEN PROVING GROUND, MD 21010-5423 CAS REGISTRY NUMBER: None CHEMICAL NAME: 1-methyl-4~piperidy] isopropylphenylglycolate hydrochloride TRADE NAME AND SYNONYMS: EA_3834A_ CHEMICAL FAMILY: Glycolic Ester Salt FORMULA/CHEMICAL STRUCTURE: C17 H26 Cl N 03 NFPA 704 SIGNAL: Health - 4 IN Flammability - 1 ey Reactivity - 0 IN IN 14 \F oy Ne, Nay vy Vl BECTION II - COMPOSITION INGREDIENTS FORMULA PERCENTAGE TL NAME BY WEIGHT EA 38340 17 H26 Cl N 03 100 * * None established/available SECTION III - PHYSICAL DATA BOILING POINT DEG F (DEG C): Extremely HighVAPOR PRESSURE (mm Hg): 1,0 X fot at 80 DEG ¢ VAPOR DENSITY (ATR=1): 11-3 SOLUBILITY (g/100g solvent) + a. Water (distilled): 13.9 @ 25 DEG C b. Other: Chloroform, 10.1 @ 25 DEG C c. Best Solvent: Water SPECIFIC GRAVITY (H20=1): 3.18 FREEZING (MELTING) POINT: 204 DRG C AUTOTGNITION TEMPERATURE DEG F (DEG C): Unknown VISCOSITY (CENTISTOKES): Not applicable SOLID DENSITY: Bulk Density - 0.47 g/om3 crystal Density ~ 1.18 g/om3 APPEARANCE AND ODOR: White solid SECTION TV - FIRE AND EXPLOSION DATA FLASHPOINT (METHOD USED): 234 PEG C (Open cup) FLAMMABILITY LIMITS (% by volume): Not available SPECIAL FIRE FIGHTING PROCEDURES: Use NIOSH approved pressure-demand ScBA for fire-fighting. UNUSUAL FIRE AND EXPLOSION HAZARDS: Not available SECTION V - HEALTH HAZARD DATA PERMISSIBLE EXPOSURE LIMIT: Data is not available to support a proposed permissible exposure limit. OO ie affecting ese, digestion, eos ivation, sweating and vision. Tts pharmacological ‘action ‘blocks ac- etylcholine centrally and peripherally 1ike atropine, with psychotomimetic Se enty. EA 3834A has more central potency than atropine, Median Lethal Dosage, Animals: ps0 (intravenous, mouse) = 50 ng/kg 24-hr [ps0 (intravenous, rat) = 1 mg/kg 24-hr ipso (intramuscular, rat) = 262 mg/kg 24-hr Median Incapacitation Dosage, Man:Teveo (inhalation, ran) = 73.4 nq-min/m3 (base equivalent corrected toa . 75 kg weight and a 15-liter respiratory minute volume) minute volume) qo“ (intravenous, mon, calculated) = 0.0068 mg/kg To-) (oral, man, calculated) = 9.118 mg/kg . ACUTE PHYSTOLOGICAL EFFECTS (ini: ial symptoms) include increased heart rate, Buintly. elevated blood pressive, moderately dilated pupils, slightly Einaued’ vision, sleepiness, light dryness of mouth, duliness in mental processes, no loss of contact with reality. Moderate symptoms include rapid pitt rate, dry lips, mouth, and skin; elevated temperature, sedation, Tooting {illusions or hallucianations, brief lapses in concentration, scene. Confusion, dizziness, voniting. Signs of severe symptoms are USty rapid heart rate, high blood pressure, dry lips, | mouth, and skin; dis- Luvhanees, in performance, menory, ‘and attention, incoherent speech, de- {iriun, vomiting, fever, dizziness, staggering, prostration, sedation, stupor, and coma. The incapacitated person mumbles to himself, picks at specks on the floor, aml fails to comprehend or respond to simple questions or instructions. He $s out of touch and unaware, Later he is amnesic for most of his ex- perience. The most noticeable peripheral autonomic effects are dry mouth ea mydriasis, which may persist after the delirium has cleared. CURONTC PHYSIOLOGICAL EFFECTS (monkeys). Intravenous daily a ys of EA seein given 20 tines in 4 weeks to groups of male and female monkeys Pro- duced the following effects: \ 0.010, 0.1, and 1.0 mg/kg Decreased locomotor activity and ataxia. 0.1 and 2.0 mg/kg Increased or decreased respiratory depth, increased respiratory, rate, mydriasis, and decreased ag- gressiveness. 1.0 ng/kg Anorexia EMERGENCY AND FIRST ALD PROCEDURES: INHALATION: Immediately remove from exposure. k medical att immediately. If breathing is ‘irregular or has stopped, start resuscitation and administer oxygen. EYE CONTACT: Flush out eyes with saline solution to prevent absorption through mucous surfaces (15 minutes). Do not rub eyes. medical attention immediately. SKIN CONTACT: Wash skin with soap and water to prevent absorption through abrasions and skin, or orally by ingestion. If washing te impossi- prong sorbent powder in the skin decontamination pad of the M13 kit may be Poskelelal. If a large quantity is on skin, add solution by washing with 1 N hydrochloric acid and then with water. Seek medical attention immediate- ly INGESTION: Cleansing the mouth with an astringent swab may be comfort~ ing and will reduce the foul breath associated with parching of the mem- ito en Fluids shou'd be given sparingly because of the danger of vomiting