Summary
In recent years attention has been paid to meibomian gland dysfunction (MGD) as a
distinct clinical entity responsible for chronic symptoms and signs and occurring
independently or in association with atopy, cicatrising mucosal disorders and rosa
cea. Attempts to correlate MGD with microbiological and lipid biochemical changes
are confounded by the absence of a clear descriptive language for the disorder and its
associated changes. Such a language is crucial for the conduct of cross-sectional and
natural history studies and therapeutic clinical trials. We present a comprehensive
classification and grading scheme of meibomian gland disease, supporting our obser
vations with illustrations.
Meibomian gland disease (MGD) is common mucous membrane of the tarsal conjunctiva,
and sometimes responsible for severe and while the anterior three quarters is skin. The
chronic symptoms and secondary conjunctival anterior margin is less sharply rounded and its
and corneal changes. The purpose of this anterior half bears multiple rows of lashes.
paper is to review its components, with par The meibomian gland orifices emerge just
ticular attention to definition and illustration. anterior to the mucocutaneous junction,
which runs as a smoothly curving line, parallel
Normal Meibomian Gland Anatomy and to the posterior margin, from one end of the
Physiology lid to the other (Fig. 1a). This cutaneous
The most anterior zone of the tear film is the location is essential for the delivery of lipid
lipid layer which derives from oil secreted onto the anterior face of the tear film. The
onto the lid margin by the meibomian glands, ductal lining is composed of keratinised
and layered onto the surface of the preocular squamous epithelium. Jester et al. have sug-
tear film with each blink. The functions of Table I. Functions of meibomian lipid
meibomian oil are listed in Table I.
1 Reduction of evaporation from the Meibomian
The normal lid margin, measured from its
preocular tear film
posterior border to the posterior lash line is 2 Enhancing tear film stability by lowering surface
approximately 2.5 mm wide in the adult and tension
presents a smooth fiat surface whose posterior 3 Prevention of spill-over of tears from the lid margin
margin is sharply rounded at about a right 4 Prevention of contamination of the tear film by
sebum
angle, to conform to the surface of the globe.
5 Scaling the apposed lid margins during sleep
The posterior quarter consists of the marginal
Correspondence to: Professor A. J. Bron. FRCS.. FCOphth. Nuffield Laboratory of Ophthalmology. Walton
'itreet, Oxford, OX2 6AW.
396 A. J. BRON ET AL.
Fig. lao Normal lid margin: Male: 12 years cutaneous Fig. ld. Normal tarsal plate: Male: Age 24 years.
part seen in specular reflection. Mucocutaneous Acini seen through conjunctiva.
junction arrowed.
Fig. lb. Normal lid margin. Male: Age 25 years. Fig. Ie. Chronic Meibomitis. Adult male. West
Normal Meibomian orifices, in this case disposed in an Indian. Lower lid everted to show rounding of posterior
irregular manner anteroposteriorly. Grey line arrowed. lid margin.
Fig. Ie. Norma/lid margin. Pigmented: West Indian Fig. If. Meibomitis: Increased vascularity of the lid
adult female. Only the punctum and inner cuffs of the margin.
Meibomian orifices are seen. The dermal ring and outer
cuff are obscured by epithelial pigment.
398 A. J. BRON ET AL.
Fig. lg. Meibomitis: 'Hyperkeratinisation' of the Fig. lj. Ridging at the mucocutaneous junction,
cutaneous part of the lid margin. running between an irregular row of Meibomian
orifices.
Fig. lh. Meibomitis: Irregularity of the posterior lid Fig. lk. Capping of a Meibomian orifice. The
margin. neighbouring orifices are relatively normal.
Fig. Ii. Severe Meibomitis in a patient with atopic Fig. 11. Meibomitis: Pouting of 2 adjacent orifices
k eratoconjunctivitis Retroplacement of the (viewed in profile).
mucocutaneous junction: The squamous metaplasia is
well behind the irregular row of Meibomian orifices
(arrow heads).
MEIBOMIAN GLAND DISEASE 399
Fig. 1m. Opaque Meibomian orifices. Those on the Fig. 10. MGD: Opaque obliterated Meibomian
left side of the picture are retroplaced. orifices.
Fig. In. Severe MGD: The central orifices (arrowed) Fig. Ip. Globular d egenerative changes seen at the lid
are opaque, and retroplaced . Adult patient with margin and resembling spheroidal degeneration.
longstanding atopic k erato conjunctivitis.
Mucous
membrane mcj
Margin a l
skin
Lashes
Fig. 2. Diagram of the Meibomian orifices and mucocutaneous junction of the lid margin.
secretion, but represented keratinised, des which are relatively constant features of the
quamated, icthyotic material accumulated lid.
within the main glandular duct. This would be Rounding of the posterior lid margin is often
in keeping with the observation of desqua associated with thickening and interferes with
mated epithelial cells in the mouths of the the normal apposition of lid to globe (Fig. Ie).
ducts demonstrated in MGD.2x-30 Vascularisation increases with age. In MGD
An acquired deficiency of meibomian there is an exaggeration of this, and an invas
glands is frequently encountered in associ ion of the outer and then inner cuffs of the ori
ation with destructive lid disease. It thus fice. (Fig. If).
occurs with staphylococcal and atopic ble Hyperkeratinisation is an eczematised appear
pharitis and in forms of cicatrising conjunctiv ance of the cutaneous margin, frequently
itis such as trachoma, mucous membrane encountered in atopes with facial eczema but
pemphigoid and erythema multiforme. Clini also in non-atopic subjects. (Fig. Ig).
cal features include absent or puckered and Irregularity of the lid margin arises from
occluded duct orifices and sufficient cicatricial absorption of tissue, often in the region of
disorganisation of the affected portions of the obliterated meibomian orifices but will occur
lid to make it impossible to assess the extent of with more gross distortions of lid architecture
gland substance present. in cicatricial and ulcerative lid disease.
(Fig. Ih).
2. Replacement of Meibomian Glands
In dystichiasis, an extra row of lashes takes Mucocutaneous Junction
the piace of the meibomian glands. The con The factors which maintain the geometry and
dition may be partial or complete and may be polarity of the mucocutaneous junction
inherited (e.g. as a dominant) or acquired (MCl) of the lid have not been explored but
focally as a metaplastic reaction to mucoc presumably are the same as those that operate
utaneous disease of the lids. at other mucocutaneous junctions. The junc
tional location and morphology may be
3. Meibomian Gland Dysfunction altered in MGD. The MCl is best identified
Meihomian gland dysfunction will be used by its specular reflection. Although the
here to imply an affection of the meibomian position of the anterior edge of the tear men
glands, without necessarily implying that iscus may correspond with it in health, in
inflammation is present. It is often associated disease it may not be an accurate guide.
with changes in the lid beyond the confines of (i) Anteroplacement: The junction becomes
the glands themselves. This section will deal irregular in MGD. The mucosa may
in particular with the individual features of spread forwards, so that the orifices
MGD. These are described in relation to appear to lie in mucosal tissue.
mucocutaneous changes, changes in the mei (ii) Retroplacement: Here, there is a pos
bomian orifices, ducts, and acini and the terior movement of the MCl, with a
secretory' performance of the gland. spreading, keratinising squamous meta
Features are described topographically to plasia of the posterior lid margin, which
include changes at the margin, mucocuta extends onto the tarsal plate. The mei
neous junction, orifices, ducts, acini and on bomian orifices may or may not move
the tarsal plate. Grading varies according to with the MCl, which will determine
the features. Greater detail is given in Table whether the tear oil is delivered onto the
III a nd is illustrated in Figures 1 and 3. surface of the tear film or not. Often,
with severe disease, this question is
Lid Margin redundant because the affected glands
Thickening of the lid is a common feature of are non-functional. Retroplacement is
meibomian gland disease, but is difficult to more common than anteroplacement.
measure because of the rounded contour of (Fig. Ii).
the anterior margin. It is best measured from (iii) Mucosal absorption: This may occur
the posterior margin to the posterior lash line, without retroplacement of the MCl so
402 A. J. BRON ET AL.
Address D. O. B.
that the MCJ and orifices are still at the of the MCJ or of tissue running between the
same distance from the lash line, but orifices. It may be an effect of mucosal
come to lie at a new posterior lid margin. absorption when a new posterior margin is
(iv) Ridging: There is a ridge-like elevation formed. (Fig. Ij).
MEIBOMIAN GLAND DISEASE 403
Table IIIb
Main ducts
Acini
Secretions
expressed .Inc. quantity OIl D 0--40 OIl D 0--4D
0= normal 1 = delay
3 = blockade .Dec. quantity 0-3D 0-4D 0-3 D 0--40
.Quality 0-30 (}-4D 0-3D 0--40
o = clear 1 cloudy
=
.Foam OIl 0 0--4D OIl 0 0--4D
2= granular
3 = opaque solid
Fig. 43. Positive fibre optic sign. The tarsal plate is Fig. 4d. MGD: Meibomian d uct exposure. Note the
illuminated with a narrow slit beam; a single large venous tributaries directed anteriorly. One large
Meibomian orifice lights up. tributary is d raining the pretarsal space. (Arrowed).
Fig. 4b. Obliterated orifices in!"aded by new vessels Fig. 4e. Two Cigar-shaped dilations of the
(arrowed). Meibomian d llcts.
Fig. 4c. Atrophic obliteration of the Meibomian Fig. 4f. A d ome of clear oil, expressed at the mouth of
orifices. The orifice structure is no longer seen. The lid a normal Meibomian gland (arrowed).
margin is relati!"ely avascular and the Meibomian acini
are seen through a/1 epithelium which is now
translucent.
406 A. J. BRaN ET AL.
Fig.4g. A d ome of very cloudy liquid secretion Fig. 4h. A small collection of turbid secretion
expressed at the mouth of diseased Meibomian gland containing particulate matter, expressed from a
(arrow head). A pouting and a capped Meibomian diseased Meibomian gland. (Arrowed).
orifice is also seen.
gin, is seen to turn on its side antero their visibility decreases with age when
posteriorly, so that it becomes visible at viewed by diffuse illumination of the tarsal
the surface of the lid margin. The outer plate, or in the presence of chronic conjunc
cuff becomes lost from view, while the tival inflammation. Observation can be
inner cuff (the epithelial lining) and the improved by infrared transillumination tech
translucent zone (the presumed dermal niques (vide supra).
layer) are seen in profile. In the early Enlargement or reduction in size of the
stages, the duct may be patent and func glands is recorded, and the presence of con
tional; later it is not. The changes may cretions and chalazia. Gifford observed that
extend over the lid margin for a number concretions might follow the line of the mei
of millimetres, which raises the question bomian glands, and believed that they were
whether it is associated with duct elonga deposits of lime salts within acini whose con
tion, or absorption of the distal part of nection with the main gland was occluded.34
the tarsal plate. (Fig. 4d). The clinical features of chalazia are well
(ii) Cystoid dilatation: Cystoid expansion known.}S Typically a chalazion starts as a hard
may be seen anywhere along the course circumscribed painless elevation on the tarsal
of the duct as a dark round or ovoid plate, visible and palpable through the skin
region along the course of a meibomian which evolves slowly with time. The lesion is
gland. Sometimes there are extended in line with a tarsal gland, which it replaces,
cigar-shaped structures which seem to and the corresponding ductular orifice is
occupy the position of one or more mei occluded, no oil being expressible. This lends
bomian glands, but it is not easy to dis credence to the general view that chalazia
tinguish dilatation of the duct from that arise as a result of obstruction of the gland,J6
of the gland acini by routine methods. with a secondary, granulomatous reaction of
(Fig. 4e). Robin et al. were able to dis the acinar and peri-acinar tissues to its lipid
tinguish both enlarged and distorted and constituents.
also shortened glands by transillumi Chalazia occur more frequently under the
nation biomicroscopy, using infrared upper than lower lid and more commonly in
light') as used by Tapie.)2 adults than in the young. Chalazia may be
single or multiple, and they may be confluent.
Acini The lid may be sufficiently thickened to pre
Visibility: As mentioned above, congenitally vent eversion. More than one lid may be
absent or deficient glands will be reflected in affected. Multiple chalazia are said to be mor<!i
deficient orifices. Though their presence may frequent in young people, especially sebor··
readily be judged in young uninflamed lids, rhoeic subjects with a history of chronic ble'!
MHBOMIAN GLAND DISEASE 407
pharoconjunctivitis,37 but also in old people or it is not excluded that either or both primary
those with rosacea. meibomian gland disease or subepithelial
scarring could be responsible.
Secretions expressed The classification scheme is not complete.
The secretory functions of the meibomian It is used operationally so that items may be
glands are assessed indirectly, by compressing added or subtracted and the grading adjusted
the tarsal plate locally in relation to individual for specific purposes. However,as many fea
groups of orifices. This may be done with fin tures as possible have been included as are
ger pressure or with a glass rod, to produce in thought to have relevance to the assessment
normal lids, a dome of clear oil over the ori of meibomian gland dysfunction. The schema
fices. Lid oil can be seen at a variable number was designed to permit a detailed assessment
of normal orifices without expression, (about of meibomian and lid morphology for the pur
64%), while about 7% of orifices open under poses of natural history and therapeutic
the tear film in normal lids.3H.3Y Absent secre studies.
tion, or blockade is encountered with many of The purpose of classifying the features of
the features described in this paper,although MGD is the opportunity which it provides to
their precise relationship has not been quantify them. The grading scheme is also
quantified. illustrated in Table III. Certain generalisa
The quality of expressed secretion which tions may be made:
can be elicited in this way in MGD is as
follows: Extent of Change
(i) Clear: (i.e. normal). (Fig. 4f). (1) Whatever the grade, the extent of lid
(ii) Cloudy: This is diffusely turbid fluid affected is recorded on a 0-4 basis to
secretion. (Fig. 4g). represent length (of lid margin) or area
(iii) Granular: This is usually a turbid, fluid (of tarsal plate) involved, in quarters (i.e.
secretion, but contains particulate 0,1,2,3,4, Nil, 0.25, 0.5,0.75, 1).
=
1-5, with grade 3 representing 'normal' where length or area of abnormality are
thickness, grades 1 and 2 representing scored.
decreased and grades 4 and 5 represent
ing increased thickness. In this and cer Discussion
tain other cases, actual measurement can Many aspects of MGD and its treatment were
replace grading. (e.g. of lid thickness, known to ophthalmologists one hundred and
retroplacement of orifices, exposure of fifty years ago. Attempts to classify it then as
the main ductules). now, combined morphological features with
Some examples of grading are given below: clinical associations in such a way as to gener
ate artificial subgroups which were not
Lid Margin mutually exclusive.
Rounding is graded 011; present or absent and MacKenzie was the first to mention chronic
the length of lid affected as 0-4. meibomitis as part of the condition of 'oph
Vascularity is graded as reduced (0/1), thalmia tarsi', in which the oil glands were dis
increased (Oil) and telangiectasia (Oil) and tended, and thickened (puriform) secretions
extent affected for each feature recorded were present in i!1creased amount.41 Scarpa
as 0-4. Cutaneous hyper-keratinisation, described a similar 'puriform palpebral flux'.42
squamous blepharitis, triehiasis, malapposi Elschnig provided a classical description of
tion in primary position or upgaze, are graded meibomian gland disease and emphasised the
as present or absent (011) and the extent of lid value of lid massage, at first daily and then at
affected graded 0-4. longer intervals, in treatment.4'.44 Gifford
described six types of disease as follows;"4
Mucocutaneous Junction
Anteroplaced: Anterior movement of the Type I: Simple Hypersecretion
mucocutaneous junction is scored 0-3, divid The expressed secretion of the glands was
ing the normal width of the skin between the abnormal. being a waxy material usually in
normal MC] and anterior lash line into thirds the form of semi-solid coils, but which could
and grading accordingly. The highest grade be of a softer consistency. The condition was
noted is scored and the extent of length of lid associated with few or no symptoms and with
affected by any abnormality of this kind is the presence of a frothy scum (equivalent to
scored 0-4. the current term 'meibomian foam'), at the
Retroplacement of the MC] is measured with inner canthus.
reference to its normal estimated location. It
may move up to 1 mm posterior (grade I); it Type 2: Simple Chronic Meibomitis (Simple
may lie>I mm but less than 2 mm posterior Inflammation)
(grade 2), or it may lie>2 mm (grade 3). Gifford conceived this type to be similar to
It will be noted, that if the mucosa of the lid type 1 and perhaps derived from it. Lid pres
margin is absorbcd, then the MC] does not sure may express a fluid of granular com
necessarily move back as a result. Mucosal position Cgrumous') or a whitish or yellowish,
absorption or ridging are recorded as present cloudy secretion, less solid than in type 1.
or absent (011) and the length of lid affected Ducts were found to be obstructed in some
recorded as 0-4. glands and acini less visible because of greater
opacity of the conjunctiva. Cases affected
Orifices with type 2 disease showed thickening of the
Reduction: The pattern of meibomian orifices lids with inflammation of the ciliary margin.
is so regular that absence of orifices can read
ily be estimated by gaps in the rows or by Type 3: Chronic Meibomitis with
examination of acini when these are visible as Hypertrophy
in the young. Abnormality is graded as 0/1; This was thought to be a more advanced form
the length affected 0-4. (The sum of lengths of stage 2, with congested and distended
over which the feature is absent is totalled for glands. Gifford described 'a strip of hyper
this purpose, and this is a general principle trophied conjunctiva, roughened and raised
MEIBOMIAN GLAND DISEASE 409
above the tarsal conjunctiva and often occlud (ciliary) lid inflammation (in the absence of a
ing the mouths of some glands'. staphylococcal superinfection).
Three further types were described on the There may be an associated meibomian
basis of an association of meibomian disease seborrhoea or secondary meibomitis (vide
with other affections such as chalazia, con infra) with dilated ductules filled with an
junctivitis, and concretions. excess of meibomian secretions, and in 95%
of cases there is an associated seborrhoeic
Type 4: Chronic meibomitis Ivith chalazia dermatitis. The latter in their series was
In this association, the lids were thickened usually mild, and variably involved scalp,
and a honey-like secretion could be expressed retroauricular skin, the nasolabial folds, brow
from all glands. Particular attention was given and sternum.
to the occurrence of multiple chalazia, occur 'Staphylococcal blepharitis' was essentially
ring as early as 711 2 of age (e.g. around 30 a clinical diagnosis in keeping with classical
chalazia) and generally presenting at an descriptions of this entity.4� There is relatively
earlier age (usually under 40 years) than the more anterior ciliary inflammation than in
other forms referred to above. seborrhoeic blepharitis and less greasy crusts
This association between meibomian gland and scales. There is only occasionally a fol
disease and chalazia was earlier referred to by licular or papillary conjunctivitis or punctate
Addaria in 1888 (leading to difficulty in com keratitis (15%). Keratoconjunctivitis sicca
plete lid opening in extreme cases)45 and by occurs in 50')10 of cases and it is preponderant
Dianoux37 and Natanson.46 It is a generally in women (80%).47
accepted association with meibomian dys In their series, culture was positive for sta
function .15 phylococcus aureus in 50%, and for staphlyo
coccus epidermidis in the remaining 50%.
Type 5: Chronic meibomitis secondary to The relative prevalence of staphylococcus
chronic conjunctivitis aureus, either alone or in combination with
In this situation, typified by the events in atro seborrhoeic blepharitis was thought to have
phic trachoma (stage 4), there is a dense con decreased in recent years. Only the staphylo
nective tissue formation overlaying and coccal group and mixed seborrhoeic/staphylo
between the acini, which often occludes ducts coccal group showed an excess of positive
leading to the formation of retention cysts. cultures for staphylococcus aureus.47
Anterior Staphylococcal
Blephartis Seborrhoeic
Alone
with staphylococci
with seborrhoea
with secondary meibomitis
Posterior Meibomian seborrhoea
Blepharitis
Primary.Meibomitis"
Secondary Meibomitis*
1 Secondary to seborrheic blepharitis
2 Secondary to other disorders
(e. g. atopy, cicatratrizing conjunctivitis etc)
efrom McCulley et al 1982.
"chalazia and concretions are regarded as
complications of meibomitis
degree. Solidification of the lipid secretions is dermatitis and atopy had the most severe signs,
prominent with resulting plugging of gland with secretions more difficult or impossible to
orifices and build-up of secretions. Primary express and with plugs extending deeper into
meibomitis is associated with bulbar injection the glands.
and tarsal papillary hypertrophy in addition to In this paper we have concentrated on the
superficial punctate keratitis and a reduced components which go to make up posterior
break-up time.4K blepharitis in the view that the detailed
The condition was found to be associated description of these changes is both scattered
with a seborrhoeic dermatitis in 36% and acne in the literature and also is incomplete. It is our
rosacea in 63% of cases. Patients are regarded particular interest to provide a tool to follow
as having a generalised problem of their seba the natural history of the changes described
ceous glands which also affects the meibo and their grouping within the major classes
mian glands. summarised by McCulley et al. 45 and to study
No specific pathogen is isolatable. not only their relation to anterior blepharitis
Meibomitis secondary to seborrhoeic blephar and dermatological status but also the overlap
itis is a patchy affection of the meibomian of occurrence of specific features within each
glands occurring in clusters along the lid mar category and their evolution with time. A
gin. The tissue surrounding the glands is proper understanding of such events will also
inflamed, and secretions within the ductules req uire a description of the changes in lid struc
are solidified and difficult to eli--press. Secon tures which occur with age and this is being
dary meibomitis is associated in 100% of cases undertaken.
with seborrhoeic dermatitis. The condition is References
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