1.The gene product of NF-1 is what kind of protein? (A) Deoxyribonucleic acid
(A) GTPase (B) Phospholipid
(B) GTPase-activating protein (C) Polysaccharide
(C) Nuclear transcription factor (D) Ribonucleic acid
(D) Receptor tyrosine kinase
8. A 46-year-old man presents with complaints of
2. A 4-year-old girl has suffered burns after being
severe headaches beginning 4 weeks prior to his
spilled with steaming hot water .The patient
visit He describes the headaches as occurring
appears to have extensive blistering of the thighs
primarily on the right side of his he ad,
and buttocks, with slight damage to the underlying
concentrated around his right eye and right temple
dermis. Her burns are best described as
The headaches tend lo occur while he is asleep
(A) third-degree burns.
and have woken him repeatedly in Ihe early
(B) fourth-degree burns.
morning What is the most likely etiology of this
(C) full-thickness burns.
patient’s headache?
(D) second-degree burns.
A. Cluster headache
3. A 74-year-old man is brought in a state of altered B. Intracranial mass
sensorium . Blood tests show a sodium level 115 C. Migraine headache
mEq/L, potassium of 3 8 mEq/L glucose of 100 mg/ D. Tension headache
dL and osmolality of 250 mOsmol/kg Urine
electrolyre testing show a urine osrnolality of 150 9. Cancer Cachexia can be attributed to which of the
mOsmol/kg X-ray of the chest shows a mass in following?
the lung Which of the following is the most likely (B) Fibroblast growth factor
etiology of the mass? (C) Interleukin-2
A. Tuberculosis (A) Platelet-derived growth factor
B. Metastatic brain cancer (D) Tumor necrosis factor-á
C. Prostate cancer
D. Small cell carcinoma 10. What is the mechanism of action of a poison that
has a scent of bitter almonds
4. A 56-year-old man is surgically treated by a four-
(A) rhabdomyolysis.
vessel coronary artery bypass graft procedure
(B) induction of direct DNA damage.
and placed on prophylactic daily aspirin therapy.
(C) inhibition of intracellular oxidative phosphorylation.
Aspirin has been shown to prevent recurrent
(D) inhibition of the oxygen-carrying capacity of hemoglobin.
myocardial infarction through its ability to inhibit
the synthesis of
11. Which of the following is the likely cause
(A) thromboxane A2 (TxA2).
convulsions?
(B) leukotriene B4 (LTB4).
(A) Vitamin B1 (thiamine) deficiency
(C) nitric oxide (NO).
(B) Vitamin B2 (riboflavin) deficiency
(D) prostaglandin I2 (PGI2).
(C) Vitamin B3 (niacin) deficiency
5. Which of the following vascular complications is (D) Vitamin B6 (pyridoxine) deficiency
associated with Marfan syndrome ?
12. Which of the following can be seen as a component
(A) Arteriovenous fistula
of the von Hippel-Lindau syndrome?
(B) Atherosclerotic aneurysm
(A) Cavernous hemangioma
(C) Berry aneurysm
(B) Glomangioma
(D) Dissecting aneurysm
(C) Hemangioendothelioma
(D) hemorrhagic telangiectasia
6. Which of the following thrombogenic processes
involving platelets is most directly impaired in 13. The gene mutated in Li-Fraumeni syndrome
deficiency of von Willebrand factor.? normally functions in what capacity?
(A) Adhesion (A) Activates the GTPase activity of the gene product of the
(B) Stabilization of platelet plug Ras oncogene
(C) Formation of fibrinogen bridges (B Halts the cell cycle if DNA damage is detected
(D) Release reaction (C) Functions as a cytoplasmic tyrosine kinase
(D) Functions as a transmembrane tyrosine kinase
7. A 4-year-old boy has ec zema and
14. In patients with chronic pancreatitis, deficiency
thrombocytopenia. There is also a history of of which of the following vitamins is most likely?
recurrent infection. His brother has similar
(A) Vitamin D
abnormalities, but none of his three sisters are (B) Vitamin B2 (riboflavin)
affected. Patients with this disorder are known (C) Vitamin B6 (pyridoxine)
to have impaired antibody response to which of
(D) Vitamin B12 (cobalamin)
the following types of antigen?
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15. Pyridoxine deficiency causes ?
(A) Defective DNA synthesis
(B) Defective production of ã-aminobutyric acid
(C) Impaired carboxylation of coagulation factors II, VII,
IX, and X
(D) Impaired hydroxyproline and hydroxylysine production
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