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QUESTIONS

Q#1 write down any 1 cause of chronic iron toxicity


Q#2 What is the treatment of acute iron toxicity
Q#3 What is the treatment of chronic iron toxicity
Q#4 Which type of defect occurs in fetus due to maternal folic acid deficiency
Q#5 Write down signs & symptoms of acute iron toxicity
KEY:

Q#1 1. Inherited hemochromatosis (due to abnormality in iron absorption) 1


2. Frequent transfusions (e.g. patient with sickle cell anemia
Q#2 Bowel irrigation to flush out unabsorbed pills, desferoxamine (iron chelating compound) 1
parenterally
Q#3 Intermittent phlebotomy, desferoxamine 1
Q#4 Neural tube defect e.g. spina bifida 1
Q#5 Depending on the dose necrotizing gastroenteritis, shock, metabolic acidosis, coma, death 1
QUESTIONS

Q#1 What is anemia?


Q#2 What is the cause of pernicious anemia?
Q#3 Give any five adverse effects of parenteral iron therapy.
KEY:

Q#1 Anemia is characterized by abnormally low blood levels of healthy RBCs or hemoglobin. (Hb.
Below 10gm./dl.
Q#2 Defective secretion of intrinsic factor by the gastric mucosal cells
Q#3 Local pain, tissue staining (brown discoloration) at the injection site, Lightheadedness, fever,
arthralgias, nausea, vomiting, back pain, urticaria, bronchospasm, anaphylaxis, death

Q#1 What is anemia?


Q#2 What is the cause of pernicious anemia
Q#3 Mention why injection Hydroxycobalamin is preferred over Cyanocobalamin in Vit. B 12 deficiency
Q#4 Give 4 common adverse effects of oral iron therapy
Q#5 Give 5 adverse effects of parenteral iron therapy
KEY:

Q#1 Anemia is characterized by abnormally low blood levels of healthy RBCs or hemoglobin. (Hb. Below
10gm./dl.
Q#2 Defective secretion of intrinsic factor by the gastric mucosal cells
Q#3 Because it is more highly bound to plasma proteins, it remains for prolonged time in the circulation.
Q#4 GIT upset including nausea, epigastric discomfort, abdominal cramps, constipation & diarrhea.
Q#5 Local pain, tissue staining (brown discoloration) at the injection site, Lightheadedness, fever, arthralgias,
nausea, vomiting, back pain, urticaria, bronchospasm, anaphylaxis, death

Q#1 write down any 1 cause of chronic iron toxicity


Q#2 What is the treatment of acute iron toxicity
Q#3 What is the treatment of chronic iron toxicity
Q#4 Which type of defect occurs in fetus due to maternal folic acid deficiency
Q#5 Write down signs & symptoms of acute iron toxicity

KEY:

Q#1 1. Inherited hemochromatosis (due to abnormality in iron absorption) 2. Frequent transfusions (e.g.
patient with sickle cell anemia
Q#2 Bowel irrigation to flush out unabsorbed pills, desferoxamine (iron chelating compound) parenterally
Q#3 Intermittent phlebotomy, desferoxamine
Q#4 Neural tube defect e.g. spina bifida
Q#5 Depending on the dose necrotizing gastroenteritis, shock, metabolic acidosis, coma, death

QUESTIONS:

Q#1 Name the drug that acts by interacting with the factor identified by the red arrow
Q#2 What route/s of administration would you use to administer this drug?
Q#3 Why does it have poor GI absorption?
Q#4 Name two main side effects of this drug.
Q#5 Name the anti-dote used to counter its effect.
KEY:

Q#1 Heparin Sulfate 1


Q#2 IV or SC 1
Q#3 Because- sulfate groups are ionized 1
Q#4 Hemorrhage and Heparin Induced Thrombocytopenia 1
Q#5 Protami ne Sulfate 1