Background: Blood pressure (BP) control among primary care patients with hypertension is subopti-
mal. Home BP monitoring (HBPM) has been shown to be effective but is underused.
Methods: This study was a quasi-experimental evaluation of the impact of the A CARE HBPM program on
hypertension control. Nonpregnant adults with hypertension or cardiovascular disease risk factors were
given validated home BP monitors and reported monthly average home BP readings by Internet or phone.
Patients and providers received feedback. Change in average home and office BP and the percentage of pa-
tients achieving target BP were assessed based on patient HBPM reports and a chart audit of office BPs.
Results: A total of 3578 patients were enrolled at 26 urban and rural primary care practices. Of
these, 36% of participants submitted >2 HBPM reports. These active participants submitted a mean of
13.5 average HBPM reports, with a mean of 19.3 BP readings per report. The mean difference in home
BP between initial and final HBPM reports for active participants was ⴚ6.5/ⴚ4.4 mmHg (P < .001) and
ⴚ6.7/ⴚ4.7 mmHg (P < .001) for those with diabetes. The percentage of active participants at or below
target BP increased from 34.5% to 53.3% (P < .001) and increased 24.6% to 40.0% (P < .001) for
those with diabetes. The mean difference in office BP over 1 year between participants and nonpartici-
pants was ⴚ5.4/ⴚ2.7 mmHg (P < .001 for systolic BP, P ⴝ .01 for diastolic BP) for all participants and
ⴚ8.5/ⴚ1.5 mmHg (P ⴝ .014 for systolic BP, P ⴝ .405 for diastolic BP) for those with diabetes.
Conclusions: An HBPM program with patient and provider feedback can be successfully implemented
in a range of primary care practices and can play a significant role in BP control and decreased cardio-
vascular disease risk in patients with hypertension. (J Am Board Fam Med 2015;28:548 –555.)
Elevated blood pressure is a major risk factor for in the United States achieve adequate blood pres-
stoke, kidney disease, and cardiovascular disease. sure control.1 In 2008, an American Heart Associ-
Yet only half of people with hypertension (HTN) ation scientific statement called for the routine use
of home blood pressure monitoring (HBPM) in
tical analysis was conducted using SAS software Home Blood Pressure Monitoring
version 9.4 (SAS Institute, Inc.). Active participants in A CARE were those who sub-
mitted at least 2 home blood pressure reports; 36% of
Results A CARE participants were active participants (see
A CARE enrolled a total of 3578 participants from Table 2). Over an average of 368 days of participa-
January 2007 to June 2010. Demographic charac- tion, active participants submitted a mean of 13.5
teristics of these patients are shown in Table 1. Of average home blood pressure reports, with a mean of
these patients, 24% had self-identified diabetes 19.3 readings per report. The average time between
mellitus. Approximately 10% of patients used the submitted reports was 56.9 days. Initial home blood
wrist cuff. pressure (systolic/diastolic) for active participants was
Table 2. Home Blood Pressure Monitoring Results (Participants Submitting >2 Reports)
All Participants Participants With Diabetes
(n ⫽ 1289) (n ⫽ 273)
*Target ⫽ home blood pressure (BP) ⬍130/80 mmHg with diabetes; home BP ⬍135/85 for all other patients.
†
P ⬍ .001.
DBP, diastolic blood pressure; HBPM, home blood pressure monitoring; SBP, systolic blood pressure.
137.6/83.0 mmHg. This decreased to 131.2/78.7 blood pressures of 352 randomly selected control
mmHg on the final home blood pressure report, for a nonparticipants. There was no significant differ-
mean difference of ⫺6.5/⫺4.4 mmHg (P ⬍ .001). ence in age or diabetes status between the 2 groups.
The percentage of these patients achieving target The A CARE participant group had a larger per-
blood pressures increased from 34.5% initially to centage of Hispanic patients than the group of
53.3% on the final home blood pressure report (P ⬍ nonparticipants (see Table 3).
.001). For participants with diabetes, the mean differ- For A CARE participants, mean office blood
ence in home blood pressure was ⫺6.7/⫺4.7 mmHg pressure decreased 6.3/4.1 mmHg, from 141.5/84.4
(P ⬍ .001), and the percentage of patients at target to 135.1/80.4 mmHg (P ⬍ .001). The change in
increased from 24.6% initially to 40.0% (P ⬍ .001). mean systolic and diastolic blood pressure in the
office for nonparticipants was not significant (see
Chart Audit Table 4). The mean difference between the A
A chart audit compared office blood pressures of CARE patients and nonparticipants was ⫺5.4/⫺2.7
378 randomly selected patients who had partici- mmHg (P ⬍ .001 for systolic blood pressure; P ⫽
pated in A CARE for at least 4 months with office .01 for diastolic blood pressure). For A CARE pa-
Table 4. Change in Mean Office Systolic and Diastolic Blood Pressure in Chart Audit Patients
A CARE Participants Nonparticipants
A CARE Participants Nonparticipants With Diabetes With Diabetes
(n ⫽ 378) (n ⫽ 352) (n ⫽ 113) (n ⫽ 97)
SBP
Initial 141.5 133.3 142.3 131.6
Final 135.1 132.5 137.0 133.7
Mean difference* ⫺6.3 ⫺0.9 ⫺5.9 ⫹2.6
(P ⬍ .001) (P ⫽ .54) (P ⫽ .0175) (P ⫽ .335)
DBP
Initial 84.4 80.9 83.0 79.5
Final 80.4 79.5 79.3 77.4
Mean difference† ⫺4.1 ⫺1.42 ⫺3.60 ⫺2.1
(P ⬍ .001) (P ⫽ .128) (P ⫽ 0.0082) (P ⫽ .1245)
*Intervention vs comparison group: P ⫽ .0003 for total, P ⫽ .0137 for patients with diabetes.
†
Intervention vs comparison group: P ⫽ .0101 for total, P ⫽ .4050 for patients with diabetes.
A CARE, Achieving Cardiovascular Excellence in Colorado.
tients with diabetes, mean office blood pressure ticipants had a significantly greater decrease in of-
decreased from 142.3/8.0 to 137.0/79.3 mmHg (see fice blood pressure readings over approximately 1
Tables 4 and 5). There was no significant change in year than nonparticipants. There was an even
mean office blood pressure for nonparticipants with greater improvement in office blood pressure mea-
diabetes. Among patients with diabetes, the mean surements for participants with diabetes, a group in
difference between the groups was ⫺8.5/⫺1.5 (P ⫽ which it is often difficult to achieve blood pressure
.014 for systolic blood pressure; P ⫽ .405 for dia- control.
stolic blood pressure). Multiple factors have kept HBPM from being
There was a 56.8% increase in the percentage widely adopted, despite recommendations for use
of patients with an at-target office blood pressure by all patients with HTN. These include the cost of
in the A CARE program, compared with a 18.8% home blood pressure monitors, which are generally
increase in the control group (P ⫽ .078; see not covered by insurance; a lack of provider rec-
Table 5). ommendations for HBPM; lack of provider trust in
HBPM accuracy, and the absence of systems that
Discussion allow patients to report HBPM results to providers.
Participants in the A CARE HBPM program had a A CARE provided home blood pressure moni-
significant decrease in average home blood pressure tors to the participants at no cost and successfully
over an average of 12 months of participation in the increased the number of underserved patients with
program (⫺6.5/⫺4.4 mmHg). A similar decrease a low socioeconomic status using HBPM. Partici-
occurred in patients with diabetes (⫺6.7/⫺4.7 pating providers knew that the home blood pres-
mmHg). These results represent a major positive sure monitors they gave to patients had been vali-
impact on the target population’s risk for cardio- dated for accuracy and that patients had been
vascular events. A population-wide 5-mmHg de- trained in their use. This allowed them to feel
crease in systolic blood pressure would be expected comfortable using HBPM results in managing their
to decrease stroke mortality by 14%, coronary patients with HTN. Indeed, 84% of providers par-
heart disease mortality by 9%, and overall mortality ticipating in A CARE who were surveyed noted
by 7%.15 that they preferentially relied on HBPM data for
Since it was not possible to compare home blood managing patients with HTN (unpublished survey
pressure readings among A CARE participants with data). The availability of the A CARE HBPM In-
home blood pressure readings among control pa- ternet and telephone reporting systems also helped
tients, it was not possible to rule out a temporal facilitate the use of HBPM in managing patients
trend toward improved blood pressure control with HTN.
among all patients, whether they participated in We did not systematically collect data concern-
HBPM or not. As a partial attempt to determine ing any side effects or issues patients had with the
the temporal trend in blood pressure control, we HBPM program, but some providers noted that
conducted a chart audit comparing office blood there are a small number of patients who develop
pressure measurements among A CARE partici- significant anxiety concerning their HBPM results.
pants with those of nonparticipants. A CARE par- These patients may tend to check their home blood
Limitations
The A CARE study assessed improvements in The authors thank the SNOCAP primary care practices, pro-
viders, and staff who participated in the A CARE program. The
blood pressure control but did not specifically eval- authors also thank the staff of the SNOCAP practice-based
uate the impact of HBPM on cardiovascular disease research networks for their support, including the Colorado
outcomes such as myocardial infarction, stroke, or Research Network (CaReNet), High Plains Research Network,
and the Building Investigative Practices for Better Health Out-
kidney disease. The A CARE study did not specif-
comes Research Network (BIGHORN).
ically address the cost-effectiveness of HBPM;
however, multiple other studies have shown that
References
HBPM is cost-effective.16 –18
1. Egan B, Zhao Y, Axon R. US trends in prevalence,
This study enrolled patients chosen by primary awareness, treatment, and control of hypertension,
care physicians and was not a randomized con- 1988 –2008. JAMA 2010;303:2043–50.
trolled trial. The HBPM program is one possible 2. Pickering T, Miller N, Ogedegbe G, Krakoff L,
explanation for the improved blood pressures in the Artinian N, Goff D. Call to action on use and reim-
A CARE group; however, it is not possible to rule bursement for home blood pressure monitoring: a
joint scientific statement from the American Heart
out some other difference between the groups that
Association, American Society Of Hypertension, and
could account for this improvement. For example, Preventive Cardiovascular Nurses Association. Hy-
there is a possibility that providers introduced bias pertension 2008;52:10 –29.
into the sample frame, choosing patients who were 3. Viera A, Cohen L, Mitchell C, Sloane P. Use of
more likely to comply with any intensive treatment home blood pressure monitoring by hypertensive