Cardiotrophin 1

Cardiotrophin-1 (CT-1) is a cytokine. It is a cardiac hypertrophic factor of 21.5

cardiotrophin 1
kDa and a protein member of the IL-6 cytokine family.
Identifiers
Symbol CTF1, CT1, CT-1

Contents Entrez 1489 (https://www.ncbi.nl

m.nih.gov/gene?cmd=retri
Pathology eve&dopt=default&list_uid
Mode of action s=1489&rn=1)
References
HUGO 2499 (https://www.genena
External links mes.org/data/gene-symbol
-report/#!/hgnc_id/HGNC:2
499)
Pathology OMIM 600435 (http://www.omim.
CT-1 is associated with the pathophysiology of heart diseases, including org/600435)
hypertension, myocardial infarction, valvular heart disease, and congestive heart RefSeq NM_001330 (https://geno
failure. me.ucsc.edu/cgi-bin/hgTra
cks?Submit=Submit&positi
Mode of action on=NM_001330&rn=1)
UniProt Q16619 (https://www.unipr
The protein exerts its cellular effects by interacting with the glycoprotein 130
ot.org/uniprot/Q16619)
(gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In
addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac Other data
myocytes and enhances transcription factor NF-κB DNA -binding activities. Locus Chr. 16 p11.2-16p11.1 (htt
p://omim.org/search?index
CT-1 is highly expressed in the heart, skeletal muscle, prostate and ovary and to
=geneMap&search=16p1
lower levels in lung, kidney, pancreas, thymus, testis and small intestine. [1]
1.2)

References
1. "Recombinant human Cardiotrophin 1 protein (ab9838)" (http://www.abcam.com/index.html?datasheet=9838).
www.abcam.com. Retrieved 2017-08-09.

External links
cardiotrophin+1 (https://meshb.nlm.nih.gov/record/ui?name=cardiotrophin%201) at the US National Library of
Medicine Medical Subject Headings (MeSH)
Irving, Michael (August 8, 2017). "The protein that can make your heart think you exercise" (http://newatlas.com/
protein-trick-heart-growth-exercise/50826). newatlas.com. Retrieved 2017-08-09.

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This page was last edited on 9 August 2017, at 20:31 (UTC).

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