("Amikacin"[Mesh]) AND "Intensive Care Units"[Mesh] AND ("last 10 years"[PDat] AND

adult[MeSH])

("Vancomycin"[Mesh]) AND "Critical Care"[Mesh] AND ("last 10 years"[PDat] AND adult[MeSH])

("Voriconazole"[Mesh]) AND "Critical Care"[Mesh] AND ("last 10 years"[PDat] AND adult[MeSH])

("Obesity"[Mesh]) AND "Critical Care"[Mesh] AND ("last 10 years"[PDat] AND adult[MeSH])

("Thinness"[Mesh]) AND "Intensive Care Units"[Mesh] AND ("last 10 years"[PDat] AND

adult[MeSH])

("Drug Monitoring"[Mesh]) AND "Intensive Care Units"[Mesh] AND ("last 10 years"[PDat] AND
adult[MeSH])

("Drug Monitoring"[Mesh]) AND "Critical Care"[Mesh] AND ("last 10 years"[PDat] AND

adult[MeSH])

("Anti-Retroviral Agents"[Mesh]) AND "Critical Care"[Mesh] AND ("last 10 years"[PDat] AND

adult[MeSH])

("Immunosuppressive Agents"[Mesh]) AND "Critical Care"[Mesh] AND ("last 10 years"[PDat] AND

adult[MeSH])

("Phenytoin"[Mesh]) AND "Critical Care"[Mesh] AND ("last 10 years"[PDat] AND adult[MeSH])

("Phenytoin"[Mesh]) AND "Drug Monitoring"[Mesh] AND ("last 10 years"[PDat] AND adult[MeSH])

("Anticonvulsants"[Mesh]) AND "Critical Care"[Mesh] AND ("last 10 years"[PDat] AND

adult[MeSH])

("Valproic Acid"[Mesh]) AND "Drug Monitoring"[Mesh] AND ("last 10 years"[PDat] AND

adult[MeSH])

("Colistin"[Mesh]) AND "Intensive Care Units"[Mesh] AND ("last 10 years"[PDat] AND adult[MeSH])

("Polypharmacy"[Mesh]) AND "intensive care units"[Mesh] AND ("last 10 years"[PDat] AND

adult[MeSH])

("Aminoglycosides"[Mesh]) AND "Critical Care"[Mesh] AND ("last 10 years"[PDat] AND

adult[MeSH])

("Drug Interactions"[Mesh]) AND "Critical Care"[Mesh] AND ("last 10 years"[PDat] AND

adult[MeSH])

("Extracorporeal Membrane Oxygenation"[Mesh]) AND "Pharmacokinetics"[Mesh] AND ("last 10

years"[PDat] AND adult[MeSH])

("Drug-Related Side Effects and Adverse Reactions"[Mesh]) AND "Critical Care"[Mesh] AND ("last
10 years"[PDat] AND adult[MeSH])
 ("Pharmacokinetics"[Mesh]) AND "Critical Care"[Mesh] AND ("last 10 years"[PDat] AND
adult[MeSH])

("Pharmacology"[Mesh]) AND "Critical Care"[Mesh] AND ("last 10 years"[PDat] AND adult[MeSH])

("Amphotericin B"[Mesh]) AND "intensive care units"[Mesh] AND ("last 10 years"[PDat] AND
adult[MeSH])

("Vasodilator Agents"[Mesh] OR "Vasoconstrictor Agents"[Mesh]) AND "Critical Care"[Mesh] AND

("last 10 years"[PDat] AND adult[MeSH])

("Pharmacists"[Mesh]) AND "Critical Care"[Mesh] AND ("last 10 years"[PDat] AND adult[MeSH])

("Pharmacists"[Mesh]) AND "Intensive Care Units"[Mesh] AND ("last 10 years"[PDat] AND

adult[MeSH])

Enteral feeding tube AND medication administration

("Economics, Pharmaceutical"[Mesh]) AND "Critical Care"[Mesh]

Score 1 2 3
Variable
Polifarmacia N° fármacos ≤ 7 8 ≤ N° N° fármacos > 11
fármacos ≤
11
Función Renal 50 ml/min ≤ClCr≤ 120 ml/min 30 ml/min ClCr<30 ml/min o ClCr> 120
≤ClCr<50 ml/min o TRR (TRRI o TRRC)
ml/min
Peso Corporal 18.5 kg/m2 ml/min ≤IMC≤ 30 kg/m2 IMC > 40 kg/m2
29,99 kg/m2 ≤IMC≤ 40
kg/m2
Fármacos de alta No uso de FAC Uso de FAC Uso FAC que requieran
complejidad que no monitoreo de niveles
requieran plasmáticos
monitoreo
de niveles
plasmáticos
Contraindicaciones, No presenta
alergias, RAM,
Interacciones
 Score
Variable 1 2 3
Polifarmacia N° fármacos ≤ 7 8 ≤ N° fármacos ≤ 11 N° fármacos >
11
Función Renal 50 ml/min ≤ClCr≤ 120 30 ml/min ≤ClCr<50ml/min ClCr<30 ml/min
ml/min o ClCr> 120
ml/min o
Necesidad de
terapia
reemplazo renal
( TRRC, HDI,
SLED, HFAV,
etc)
Peso corporal 18.5 kg/m2 ml/min 30 kg/m2 ≤IMC≤ 40 kg/m2 IMC > 40 kg/m2
≤IMC≤ 29,99 kg/m2 IMC < 18,5
kg/m2
Fármacos de alta No usa Colistin Vancomicina
complejidad Amikacina Voriconazol
TARV Valproico
Tacrolimus Fenitoína
Anticancerígenos
Contraindicaciones, No presenta Presenta a lo más 1 Presenta más de
Alergias, Interacciones contraindicación o 1 alergia o 1 1 CI o 1 alergia o
Fco-Fco, RAM interacción clínica relevante o 1 interacción o 1
1 RAM. RAM o una
combinación de
ellas.

EMBASE

voriconazole':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND [2008-2018]/py AND ([adult]/lim OR

[aged]/lim OR [middle aged]/lim OR [very elderly]/lim) AND [embase]/lim: 84

'amikacin':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND [2008-2018]/py AND ([adult]/lim OR [middle
aged]/lim OR [aged]/lim OR [very elderly]/lim) AND [embase]/lim: 101
'vancomycin':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND [2008-2018]/py AND ([adult]/lim OR [middle
aged]/lim OR [aged]/lim OR [very elderly]/lim) AND [embase]/lim 479

'drug monitoring':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND [2008-2018]/py AND ([adult]/lim OR
[middle aged]/lim OR [aged]/lim OR [very elderly]/lim) AND [embase]/lim: 84

'immunosuppressive agent':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND [2008-2018]/py AND ([adult]/lim
OR [middle aged]/lim OR [aged]/lim OR [very elderly]/lim) AND [embase]/lim: 1

'antiretroviral therapy':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND [2008-2018]/py AND ([adult]/lim OR
[middle aged]/lim OR [aged]/lim OR [very elderly]/lim) AND [embase]/lim: 53

'obesity':ti,ab,kw AND 'intensive care':ti,ab,kw AND 'drug dosing':ti,ab,kw: 3

'body weight':ti,ab,kw AND 'drug dosing':ti,ab,kw AND ([adult]/lim OR [middle aged]/lim OR

[aged]/lim OR [very elderly]/lim) AND [embase]/lim: 48

'phenytoin':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND ([adult]/lim OR [middle aged]/lim OR

[aged]/lim OR [very elderly]/lim) AND [embase]/lim AND [2008-2018]/py: 54

'valproic acid':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND ([adult]/lim OR [middle aged]/lim OR
[aged]/lim OR [very elderly]/lim) AND [embase]/lim AND [2008-2018]/py: 21

'colistin':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND ([adult]/lim OR [middle aged]/lim OR

[aged]/lim OR [very elderly]/lim) AND [embase]/lim AND [2008-2018]/py: 200

'amphotericin b':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND ([adult]/lim OR [middle aged]/lim
OR [aged]/lim OR [very elderly]/lim) AND [embase]/lim AND [2008-2018]/py: 94

'polypharmacy':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND ([adult]/lim OR [middle aged]/lim

OR [aged]/lim OR [very elderly]/lim) AND [embase]/lim AND [2008-2018]/py: 29

'solid organ transplantation':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND ([adult]/lim OR

[middle aged]/lim OR [aged]/lim OR [very elderly]/lim) AND [embase]/lim AND [2008-2018]/py

'ecmo':ti,ab,kw AND 'pharmacokinetics':ti,ab,kw AND ([adult]/lim OR [middle aged]/lim OR

[aged]/lim OR [very elderly]/lim) AND [embase]/lim AND [2008-2018]/py: 43

'therapeutic drug monitoring':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND ([adult]/lim OR

[middle aged]/lim OR [aged]/lim OR [very elderly]/lim) AND [embase]/lim AND [2008-2018]/py: 72
'adverse drug reaction':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND ([adult]/lim OR [middle
aged]/lim OR [aged]/lim OR [very elderly]/lim) AND [embase]/lim AND [2008-2018]/py: 52

'pharmacokinetics':ti,ab,kw AND 'critically ill patient':ti,ab,kw AND ([adult]/lim OR [middle

aged]/lim OR [aged]/lim OR [very elderly]/lim) AND [embase]/lim AND [2008-2018]/py: 36

'pharmacist':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND ([adult]/lim OR [middle aged]/lim OR

[aged]/lim OR [very elderly]/lim) AND [embase]/lim AND [2008-2018]/py: 167

'drug interaction':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND ([english]/lim OR [spanish]/lim)

AND ([adult]/lim OR [middle aged]/lim OR [aged]/lim OR [very elderly]/lim) AND [embase]/lim
AND [2008-2018]/py: 41

'qt prolongation':ti,ab,kw AND 'intensive care unit':ti,ab,kw AND ([english]/lim OR [spanish]/lim)

AND ([adult]/lim OR [middle aged]/lim OR [aged]/lim OR [very elderly]/lim) AND [embase]/lim
AND [2008-2018]/py: 14
feeding tube':ti,ab,kw AND 'pharmacist':ti,ab,kw AND ([english]/lim OR [spanish]/lim) AND ([adult]/lim OR
[middle aged]/lim OR [aged]/lim OR [very elderly]/lim) AND [embase]/lim AND [2008 -2018]/py: 7