Pharmaceutical chemistry

ASSAY OF MAGNESIUM SULFATE

AIM: to perform assay of a given sample og magnesium sulfate

Principal: magnesium sulfate is an example of saline cathartic. It is assayed by titration with 0.05M
EDTA using pH 10 buffer and solochrome black T indicator. EDTA forms Magnesium EDTA complex.
The colour change of the indicator is from wine red to blue at the end point.

Materials

 EDTA 0.05M
 Ph 10 Buffer
 0.05M CaCl2
 Solochrome black T Indicato(sBT)
 Magnesium sulfate

Stardadization of EDTA
PROCEDURE
1. Pipette 10ml of 0.05m cacl2 solution in a conical flask and 5ml of pH 10 buffer solution.
2. Add 2-3 drops of DBT indicator and titrate against EDTA.
3. Repeat the titration for concordant values.

ASSAY
1. Weigh accurately 0.1g of mgSo4 and dissolve in 50ml of water.
2. Add 10ml of pH buffer 10 solution and 3-4 drops of SBT indicator.
3. Titrate the content against EDTA.
4. Repeat the titration for concordant values.