Drugs that are not-polar are not soluble in water and thus cannot be absorbed by tissue
very well. Also, low polarity (and thus low solubility) create effective treatment caps for
drugs. For example, some vitamins are not very soluble so even if you consume a large
quantity, they will not be effective. However, there is also a negative side: some vitamins,
because they are not soluble, may stay inside your body for long periods of time,
possibly causing negative effects.
1. External factors are factors like temperature, PH, dosage form and so on. Temperature
— The higher temperature, the more soluble the drug. PH — Acid and base drugs have
solubility equilibriums in water medium. ... Dosage form — Gaseous drug is more
soluble than liquid drug, which is more soluble than solid one.
All factors can be categorized into two: internal and external factors.
Internal factors are governed the molecular structure. If the structure of a drug molecule
allows it form more intermolecular interactions with the solvent, the higher solubility it
has. For example, if an organic drug molecule has more hydrogen bond donating and/or
accepting groups like -OH, -NH2, -COO- and so on, then it can form more hydrogen
bonds with water solvent. Therefore it is more soluble in water.
2. External factors are factors like temperature, PH, dosage form and so on.
Reference: https://www.google.com/search?
ei=Qf46XfHBGa_YhwOUyquIBA&q=differentiate+ideal+from+non+ideal+solution&oq=dif
ferentiate+ideal+from+non+ideal+solution&gs_l=psy-
ab.3..0i22i30.149222.166246..166558...2.0..0.309.6279.0j40j2j1......0....1..gws-
wiz.....10..0i71j35i39j0j0i131j0i67j0i70i255j0i20i263j0i10.UXWzaMaDiVU&ved=0ahUKE
wix5obR1tLjAhUv7GEKHRTlCkEQ4dUDCAo&uact=5
1. Complete disintegration is defined as that state in which any residue of the. 15.
unit, except fragments of insoluble coating or capsule shell, remaining on the screen
of the test.
Disintegration testers are used to test how a drug in pellet form will disintegrate in
solution. Like dissolution testers, they permit researchers and medical practitioners
to analyze the in vitro breakdown of powdered compounds for quality
control purposes.