MSS Basic Science Reviewer: Biochem

Proteins outline
Based on BRS: o Nomenclature
 Protein structure o Properties
o General aspects of protein o How they work
structure o Factors affecting reaction
o Hemoglobin velocity
o Collagen o Michaelis-Menten Equation
o Insulin o Inhibition of Enzyme Activity
 Enzymes o Regulation of Enzyme Activity
o General Properties o Enzymes in Clinical Diagnosis
o Dependence of velocity on [E],
[S], temperature, and pH Based on USMLE First Aid Step 1
o The Michaelis-Menten equation  Protein Synthesis
o The Lineweaver-Burk equation  Collagen
o Inhibitors of enzyme decrease  Collagen Synthesis
the rate of enzymatic reactions  Elastin
o Allosteric enzymes
o Regulation of enzyme activity Based on Kaplan USMLE 1
by covalent modification  General structure
o Regulation by protein-protein  Classification
interactions  Essential Amino Acids
o Isoenzymes  Nitrogen Balance
 Biochemical Reactions
Based on Lippincott’s Illustrated Reviews – o Michaelis-Menten Equation
Biochemistry 5E o Lineweaver-Burk Equation
 Amino acids  Inhibitors and Activators
o Structure  Cooperative Enzyme Kinetics
o Acidic and Basic Properties  Transport Kinetics
 Structure of Proteins
o Primary Structure
o Secondary Structure
o Tertiary Structure
o Quaternary Structure
o Protein Misfolding
 Globular Proteins
o Globular Hemeproteins
o Organization of the Globin
Genes
o Hemoglobinopathies
 Fibrous Proteins
o Collagen
o Elastin
 Enzymes