Pedoman Antibiotika Interna
Pedoman Antibiotika Interna
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Toksoplasmosis I. Pirimetamine oral + 1x100 lanjut 1x50 mg 24 jam + 6 minggu
Serebral Clindamycin oral + + 4x600 mg + 6 jam +
Folinate Acid oral 15 mg 48 jam
Mycobacterium I. Azitromycin oral 1x500 mg 24 jam 6 minggu
Avium Complex II. Clarithromycin oral + 2x500 mg + 12 jam + 6 minggu
(MAC) Etambutol oral + 1x15 mg/kgBB + 24 jam +
Levofloxacin oral 1x500 mg 24 jam
5. Pneumonia RS Gram-Positive I. Vancomycin IV 3x15 mg/kg 8 jam 7-10 hari
Antibiotics With
MRSA Activity II. Linezolid IV 2x600 mg 12 jam 7-10 hari
Gram-Negative I. Piperacillin-tazobactam IV 4x4.5 g 6 jam 5-14 hari
Antibiotics With II. Cefepime IV 3x2 g 8 jam 5-14 hari
Antipseudomonal Ceftazidime IV 3x2 g 8 jam 5 hari
Activity: ß-Lactam III. Imipenem IV 4x500 mg 6 jam 5 hari
Based Agents Meropenem IV 3x1 g 8 jam 5 hari
IV. Aztreonam IV 3x2 g 8 jam 5 hari
Gram-Negative I. Ciprofloxacin IV 3x400 mg 8 jam 5 hari
Antibiotics With Levofloxacin IV 1x750 mg 24 jam 5 hari
Antipseudomonal II. Amikacin IV 1x15-20 mg/kg 24 jam 5 hari
Activity: Non-ß- Gentamicin IV 1x5-7 mg/kg 24 jam 5 hari
Lactam–Based Tobramycin IV 1x5-7 mg/kg 24 jam 5 hari
Agents III. Colistin IV 2x2.5 mg/kg 12 jam 5-14 hari
IV. Polymyxin B IV 2.5-3.0 mg/kg 48 jam 5-14 hari
6. Pneumonia Streptococcus I. Penicillin G IV 4x1-2 g 6 jam 5 hari
Komuniti pneumonia Amoxicillin IV 3x1 g 6 jam 5 hari
Penicillin II. Azithromycin oral 1x500 mg 24 jam 3-5 hari
nonresistant Cefuroxime oral 2x500 mg 12 jam 5 hari
Ceftriaxone IV 1x1-2 g 24 jam 5 hari
Clindamycin oral 4x150-300 mg 6 jam 5 hari
Doxycyline oral 1x100 mg 24 jam 5 hari
Levofloxacin oral 1x500 mg 24 jam 5 hari
Streptococcus I. Cefotaxime IV 3x1-2 g 8 jam 5-7 hari
pneumonia Ceftriaxone IV 1x1-2 g 24 jam 5-7 hari
Penicillin resistant Levofloxacin oral 1x500 mg 24 jam 5 hari
II. Vancomycin IV 3x15 mg/kg 8 jam 5 hari
Linezolid IV 2x600 mg 12 jam 5 hari
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Haemophilus I. Amoxicillin oral 4x500 mg 6 jam 5 hari
influenzae II. Levofloxacin oral 1x500 mg 24 jam 5 hari
Non–Beta- Doxycycline oral 1x100 mg 24 jam 5 hari
lactamase Azithromycin oral 1x500 mg 24 jam 5 hari
producing Clarithromycin oral 2x500 mg 12 jam 5 hari
Haemophilus I. Ceftriaxone IV 1x1-2 g 24 jam 5 hari
influenzae Beta- Amoxicillin-clavulanate IV 3x1 g 8 jam 5 hari
lactamase II. Levofloxacin oral 1x500 mg 24 jam 5 hari
producing Doxycycline oral 1x100 mg 24 jam 5 hari
Azithromycin oral 1x500 mg 24 jam 5 hari
Clarithromycin oral 2x500 mg 12 jam 5 hari
Mycoplasma I. Azithromycin oral 1x500 mg 24 jam 5 hari
pneumoniae/ Doxycycline oral 1x100 mg 24 jam 5 hari
Chlamydophila II. Levofloxacin oral 1x500 mg 24 jam 5 hari
pneumoniae
Legionella species I. Levofloxacin oral 1x500 mg 24 jam 5 hari
Azithromycin oral 1x500 mg 24 jam 5 hari
II. Doxycyline oral 1x100 mg 24 jam 5 hari
Enterobacteriaceae I. Ceftriaxone IV 1x1-2 g 24 jam 5 hari
Meropenem IV 3x1 g 8 jam 5 hari
II. Amoxicillin-clavulanate IV 3x1 g 8 jam 5 hari
Levofloxacin IV 1x750 mg 24 jam 5 hari
Pseudomonas I. Ceftazidime IV + 3x2 g + 8 jam + 5-7 hari
aeruginosa Levofloxacin IV 1x750 mg 24 jam 5-7 hari
II. Amikacin IV + 1x15-20 mg/kg + 24 jam + 5-7 hari
Levofloxacin IV 1x750 mg 24 jam 5-7 hari
Acinetobacter I. Meropenem IV 3x1 g 8 jam 5-7 hari
species II. Ceftriaxone IV + 1x1-2 g + 24 jam + 5-7 hari
Amikacin IV 1x15-20 mg/kg 24 jam 5-7 hari
Ampicillin-Sulbactam IV 4x1.5 g 6 jam 5-7 hari
Colistin IV 2x2.5 mg/kg 12 jam 5-7 hari
Methicillin- I. Ampicillin-Sulbactam IV 4x1.5 g 6 jam 5-7 hari
susceptible II. Cefazolin IV 3x2 g 8 jam 5-7 hari
Staphylococcus Clindamycin oral 4x300 mg 6 jam 5-7 hari
aureus (MSSA)
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Methicillin-resistant I. Vancomycin IV 3x15 mg/kg 8 jam 5 hari
Staphylococcus II. Linezolid IV 2x600 mg 12 jam 5 hari
aureus (MRSA) III. TMP-SMX oral 2x160/800 mg 12 jam 5-7 hari
7. Luka Diabetes Methicillin- I. Dicloxacillin oral 4x250 mg 6 jam 7-10 hari
Derajat Ringan susceptible S. II. Clindamycin oral 4x300 mg 6 jam 7-10 hari
aureus (MSSA) Cephalexin oral 2x500 mg 12 jam 7-10 hari
Streptococcus spp III. Levofloxacin oral 1x500 mg 24 jam 7-10 hari
Amoxicillin-clavulanate oral 3x625 mg 8 jam 7-10 hari
Methicillin-resistant I. Doxycycline oral 1x100 mg 24 jam 7-10 hari
S. aureus (MRSA) II. TMP-SMX oral 2x160/800 mg 12 jam 7-10 hari
8. Luka Diabetes Methicillin- I. Levofloxacin IV 1x750 mg 24 jam 7-14 hari
Derajat Berat susceptible S. II. Ceftriaxone IV 1x2 g 24 jam 7-14 hari
aureus (MSSA) Ampicillin-sulbactam IV 4x1.5 g 6 jam 7-14 hari
Streptococcus spp III. Moxifloxacin IV 1x400 mg 24 jam 7-14 hari
Enterobacteriace Ertapenem IV 1x1 g 24 jam 7-14 hari
Tigecycline IV 2x50 mg 12 jam 7-14 hari
Methicillin-resistant I. Linezolid IV 2x600 mg 12 jam 7-14 hari
S. aureus (MRSA) II. Daptomycin IV 1x200 mg 24 jam 7-14 hari
III. Vancomycin IV 3x15 mg/kg 8 jam 7-14 hari
Pseudomonas I. Piperacillin-tazobactam IV 3x4.5 g 8 jam 5 hari
aeruginosa
9. Infeksi Saluran E. coli with I. Fosfomycin IV 1x3 g 24 jam 1 hari
Kemih Bawah Extended Spectrum Nitrofurantoin oral 2x100 mg 12 jam 5-7 hari
(Cystitis) Non Beta-Lactamase II. Ciprofloxacin oral 2x250 mg 12 jam 3 hari
Komplikata (ESBL) Levofloxacin oral 1x250 mg 24 jam 3 hari
Ofloxacin oral 2x250 mg 12 jam 3 hari
III. Cefadroxil oral 2x500 mg 12 jam 5 hari
TMP- SMX oral 2x160/800 mg 12 jam 3 hari
10. Infeksi Saluran E. coli with I. Ciprofloxacin oral 2x500-750 mg 12 jam 5-7 hari
Kemih Atas Extended Spectrum Levofloxacin oral 1x500 mg 24 jam 5-7 hari
(Pyelonephritis) Beta-Lactamase II. TMP-SMX oral 2x160/800 mg 12 jam 3 hari
Non Komplikata (ESBL) Amoxicillin-clavulanate oral 3x0.5/0.125 g 8 jam 7-10 hari
III. Cefotaxime IV 3x2 g 8 jam 7-10 hari
Ceftriaxone IV 1x1-2 g 24 jam 7-10 hari
Cefepime IV 2x1-2 g 12 jam 7-10 hari
Meropenem IV 3x1 g 8 jam 7-10 hari
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11. Infeksi Saluran E. coli I. Levofloxacin IV 1x750 mg 24 jam 5 hari
Kemih Komplikata Proteus sp. Ampicillin-sulbactam IV 4x1.5 g 6 jam 5 hari
Pseudomonas sp. Ceftriaxone IV 1x2 g 24 jam 5 hari
Klebsiella II. Piperacillin-tazobactam IV 3x4.5 g 8 jam 5 hari
Ceftazidime IV 3x2 g 8 jam 5 hari
Meropenem IV 3x1 g 8 jam 5 hari
12. Sepsis Pneumonia RS I. Piperacillin-tazobactam IV 3x4.5 g 8 jam 7-10 hari
II. Meropenem IV (risiko ESBL) 3x1 g 8 jam 7-10 hari
III. Cefepime IV 3x2 g 8 jam 7-10 hari
IV. Aztreonam IV 3x2 g 8 jam 7-10 hari
Infeksi Saluran I. Piperacillin-tazobactam IV 3x4.5 g 8 jam 7-10 hari
Kemih RS Meropenem IV (risiko ESBL) 3x1 g 8 jam 7-10 hari
II. Aztreonam IV 3x2 g 8 jam 7-10 hari
Infeksi Intra I. Piperacillin-tazobactam IV 3x4.5 g 8 jam 7-10 hari
Abdominal RS II. Meropenem IV (risiko ESBL) 3x1 g 8 jam 7-10 hari
III. Cefepime IV + Metronidazole IV 3x2 g + 3x500 mg 8 jam 7-10 hari
IV. Aztreonam IV + Metronidazole IV 3x2 g + 3x500 mg 8 jam 7-10 hari
Infesi Kulit RS I. Vancomycin IV 3x15 mg/kg 8 jam 5-7 hari
Pneumonia I. Ceftriaxone IV + Azithromycin IV 1x2 g + 1x500mg 24 jam + 24 jam 5-7 hari
Komuniti II. Ceftriaxone IV + Doxycycline IV 1x2 g + 2x100mg 24 jam + 12 jam 5-7 hari
III. Levofloxacin IV 1x750 mg 24 jam 5-7 hari
Infeksi Saluran I. Ertapenem IV 1x1 g 24 jam 5-7 hari
Kemih Komuniti II. Aztreonam IV 3x2 g 8 jam 5-7 hari
Infeksi Intra I. Piperacillin-tazobactam IV 3x4.5 g 8 jam 5-7 hari
Abdominal II. Ertapenem IV 1x1 g 24 jam 5-7 hari
Komuniti III. Aztreonam IV + Metronidazole IV 3x2 g + 3x500mg 8 jam 5-7 hari
Infeksi Kulit I. Cefazolin IV 3x2 g 8 jam 5-7 hari
Komuniti
Keterangan
MRSA : Methicillin-Resistant Staphylococcus aureus
MSSA : Methicillin-Susceptible Staphylococcus aureus
ECBL : Extended Spectrum Beta-Lactamase
BLI : Beta-Lactamase Inhibitor
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Kebijakan Khusus Antibiotik