PMID- 31352198

OWN - NLM
STAT- Publisher
LR - 20190807
IS - 1936-5233 (Print)
IS - 1936-5233 (Linking)
VI - 12
IP - 10
DP - 2019 Jul 25
TI - Emerging Pathogenic and Prognostic Significance of Paired Box 3 (PAX3)
Protein in
Adult Gliomas.
PG - 1357-1363
LID - S1936-5233(19)30340-7 [pii]
LID - 10.1016/j.tranon.2019.07.001 [doi]
AB - Gliomas present the most common type of brain tumors in adults, characterized
by
high morbidity and mortality. In search of potential molecular targets,
members
of paired box (PAX) family have been found expressed in neural crest cells,
regulating their proliferation, apoptosis, migration and differentiation.
Recently, PAX3 overexpression has been implicated in glioma tumorigenesis by
enhancing proliferation, increasing invasiveness and inducing resistance to
apoptosis of glioma cells, while maintaining brain glioma stem cells (BGSCs)
stemness. Although the oncogenic potential of PAX3 in gliomas is still under
investigation, experimental evidence suggests that PAX3 function is mainly
mediated through the canonical and non-canonical Wnt signaling pathway as
well as
through its interaction with GFAP and p53 proteins. In addition, PAX3 may
contribute to the chemoresistance of glioma cells and modulates the
effectiveness
of novel experimental therapies. Further evidence indicates that PAX3 may
represent a novel diagnostic and prognostic biomarker for gliomas,
facilitating
personalized treatment. This review addresses the emerging role of PAX3 in
glioma
diagnosis, prognosis and treatment, aiming to shed more light on the
underlying
molecular mechanisms that could lead to more effective treatment approaches.
CI - Copyright (c) 2019 The Authors. Published by Elsevier Inc. All rights
reserved.
FAU - Angelopoulou, Efthalia
AU - Angelopoulou E
AD - Department of Biological Chemistry, Medical School, National and Kapodistrian
University of Athens, Athens, Greece.
FAU - Paudel, Yam Nath
AU - Paudel YN
AD - Neuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and
Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor,
Malaysia.
FAU - Piperi, Christina
AU - Piperi C
AD - Department of Biological Chemistry, Medical School, National and Kapodistrian
University of Athens, Athens, Greece. Electronic address: cpiperi@med.uoa.gr.
LA - eng
PT - Journal Article
DEP - 20190725
PL - United States
TA - Transl Oncol
JT - Translational oncology
JID - 101472619
PMC - PMC6664158
EDAT- 2019/07/29 06:00
MHDA- 2019/07/29 06:00
CRDT- 2019/07/29 06:00
PHST- 2019/07/02 00:00 [received]
PHST- 2019/07/08 00:00 [accepted]
PHST- 2019/07/29 06:00 [pubmed]
PHST- 2019/07/29 06:00 [medline]
PHST- 2019/07/29 06:00 [entrez]
AID - S1936-5233(19)30340-7 [pii]
AID - 10.1016/j.tranon.2019.07.001 [doi]
PST - aheadofprint
SO - Transl Oncol. 2019 Jul 25;12(10):1357-1363. doi:
10.1016/j.tranon.2019.07.001.