Endometrial hyperplasia
From Libre Pathology
Contents
1 Overview
1.1 WHO endometrial hyperplasia classification of 2014
1.2 WHO endometrial hyperplasia classification of 1994
1.3 Alternate classifications - overview
1.3.1 European group of experts classification
1.3.2 Endometrial collaborative group/Harvard classification
1.4 WHO classification of 1994
1.4.1 Management of endometrial hyperplasia
1.4.2 Risk of progression to carcinoma as per 1994 system
1.4.3 Ki-67
1.5 WHO system of 1994 - detail articles
1.5.1 Simple endometrial hyperplasia
1.5.2 Simple endometrial hyperplasia with atypia
1.5.3 Complex endometrial hyperplasia
1.5.4 Complex endometrial hyperplasia with atypia
2 Other
2.1 Endometrial hyperplasia with secretory changes
2.1.1 General
2.1.2 Microscopic
3 See also
4 References
Overview
WHO endometrial hyperplasia classification of 2014
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Two alternative grading systems exist, that are (currently) not widely used:[2]
Both consist of two categories, as opposed to four found in the WHO classification.
1. Endometrial hyperplasia.
2. Endometrioid neoplasia.
1. Endometrial hyperplasia.
2. Endometrial intraepithelial neoplasia (EIN).
Simple Complex
Without atypia 1% 3%
With atypia 9% † 27% ‡
Notes:
Ki-67
Abbreviated CEH.
Other
Endometrial hyperplasia with secretory changes
General
Rare.
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Microscopic
Features:[9]
Notes:
† This is not precisely defined. I suppose it is some of the things Bell and Ostrezega[11] mention (mitoses,
nuclear atypia, pseudostratified epithelium).
Bell and Ostrezega[11] give a laundry list for differentiating benign secretory endometrium from
hyperplasia with secretory changes: focal architectural abnormalities, metaplastic ciliated & "clear"
cells, sharp luminal border, epithelial pseudopalisading, nuclear atypia, vesicular nuclei, mitoses.
DDx:
Images:
See also
Endometrium.
Endometrial carcinoma.
Gynecologic pathology.
References
Virchows Arch 439 (5): 604-8. PMID 11764378 (http://
1. Emons, G.; Beckmann, MW.; Schmidt, D.; Mallmann, www.ncbi.nlm.nih.gov/pubmed/11764378).
P. (Feb 2015). "New WHO Classification of 3. URL: http://www.aafp.org/afp/990600ap/3069.html.
Endometrial Hyperplasias.". Geburtshilfe Frauenheilkd 4. URL: http://www.aafp.org/afp/20060801/practice.html.
75 (2): 135-136. doi:10.1055/s-0034-1396256 (http://d 5. Latta, E. January 2009.
x.doi.org/10.1055%2Fs-0034-1396256). 6. Kurman, RJ.; Kaminski, PF.; Norris, HJ. (Jul 1985).
PMID 25797956 (http://www.ncbi.nlm.nih.gov/pubme "The behavior of endometrial hyperplasia. A long-term
d/25797956). study of untreated hyperplasia in 170 patients.". Cancer
2. Dietel, M. (Nov 2001). "The histological diagnosis of 56 (2): 403-12. PMID 4005805 (http://www.ncbi.nlm.n
endometrial hyperplasia. Is there a need to simplify?". ih.gov/pubmed/4005805).
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