@article{yu2013determination,

title={Determination of sulfonamides in blood using acetonitrile--salt aqueous

two-phase extraction coupled with high-performance liquid chromatography and liquid
chromatography--tandem mass spectrometry},
author={Yu, Wei and Liu, Zhongling and Gao, Shiqian and Cui, Shusen and Yang,
Xiao and Qiu, Wei and Zhang, Hanqi and Yu, Aimin and Huan, Yanfu},
journal={Analytical Methods},
volume={5},
number={21},
pages={5983--5989},
year={2013},
publisher={Royal Society of Chemistry}
}

@article{nebot2013rapid,
title={Rapid method for quantification of nine sulfonamides in bovine milk using
HPLC/MS/MS and without using SPE},
author={Nebot, Carolina and Regal, Patricia and Miranda, Jose Manuel and Fente,
Cristina and Cepeda, Alberto},
journal={Food chemistry},
volume={141},
number={3},
pages={2294--2299},
year={2013},
publisher={Elsevier}
}

@article{el2000studies,
title={Studies on aminopyrazoles: antibacterial activity of some novel pyrazolo
[1, 5-a] pyrimidines containing sulfonamido moieties},
author={El-Gaby, MSA and Atalla, AA and Gaber, AM and Al-Wahab, KA Abd},
journal={Il Farmaco},
volume={55},
number={9-10},
pages={596--602},
year={2000},
publisher={Elsevier}
}

@article{el2002novel,
title={Novel synthesis and antifungal activity of pyrrole and pyrrolo [2, 3-d]
pyrimidine derivatives containing sulfonamido moieties},
author={El-Gaby, MSA and Gaber, AM and Atalla, AA and Al-Wahab, KA Abd},
journal={Il Farmaco},
volume={57},
number={8},
pages={613--617},
year={2002},
publisher={Elsevier}
}
@article{doi:10.1146/annurev.pa.16.040176.001521,
author = {Maren, T H},

title = {Relations Between Structure and Biological Activity of Sulfonamides},

journal = {Annual Review of Pharmacology and Toxicology},

volume = {16},

number = {1},

pages = {309-327},

year = {1976},

doi = {10.1146/annurev.pa.16.040176.001521},

note ={PMID: 59572},

URL = {

https://doi.org/10.1146/annurev.pa.16.040176.001521

},
eprint = {

https://doi.org/10.1146/annurev.pa.16.040176.001521

@article{ghorab2015synthesis,
title={Synthesis, anticancer and radiosensitizing evaluation of some novel
sulfonamide derivatives},
author={Ghorab, Mostafa M and Ragab, Fatma A and Heiba, Helmy I and El-Gazzar,
Marwa G and Zahran, Sally S},
journal={European journal of medicinal chemistry},
volume={92},
pages={682--692},
year={2015},
publisher={Elsevier}
}

@article{boechat2011design,
title={Design and synthesis of new N-(5-trifluoromethyl)-1H-1, 2, 4-triazol-3-yl
benzenesulfonamides as possible antimalarial prototypes},
author={Boechat, Nubia and Pinheiro, Luiz and Santos-Filho, Osvaldo A and Silva,
Isabor C},
journal={Molecules},
volume={16},
number={9},
pages={8083--8097},
year={2011},
publisher={Molecular Diversity Preservation International}
}
@article{greig2013development,
title={Development of triarylsulfonamides as novel anti-inflammatory agents},
author={Greig, Iain R and Coste, Emmanuel and Ralston, Stuart H and van�t Hof,
Robert J},
journal={Bioorganic \& medicinal chemistry letters},
volume={23},
number={3},
pages={816--820},
year={2013},
publisher={Elsevier}
}

@article{doi:10.1021/jm0494974,

author = {Banerjee, Mithu and Poddar, Asim and Mitra, Gopa and Surolia, Avadhesha
and Owa, Takashi and Bhattacharyya, Bhabatarak},

title = {Sulfonamide Drugs Binding to the Colchicine Site of Tubulin:?

Thermodynamic Analysis of the Drug-Tubulin Interactions by Isothermal Titration
Calorimetry},
journal = {Journal of Medicinal Chemistry},

volume = {48},

number = {2},

pages = {547-555},

year = {2005},

doi = {10.1021/jm0494974},
note ={PMID: 15658868},

URL = {https://doi.org/10.1021/jm0494974

},
eprint = {https://doi.org/10.1021/jm0494974
}

}
@Article{molecules15129046,

AUTHOR = {Chen, Zhuo and Xu, Weiming and Liu, Keming and Yang, Song and Fan, Huitao
and Bhadury, Pinaki S. and Huang, De-Yu and Zhang, Yuping},
TITLE = {Synthesis and Antiviral Activity of 5-(4-Chlorophenyl)-1,3,4-Thiadiazole
Sulfonamides},

JOURNAL = {Molecules},

VOLUME = {15},

YEAR = {2010},

NUMBER = {12},

PAGES = {9046--9056},

URL = {http://www.mdpi.com/1420-3049/15/12/9046},
PubMedID = {21150824},

ISSN = {1420-3049},

ABSTRACT = {Starting from 4-chlorobenzoic acid, 10 new 5-(4-chlorophenyl)-N-

substituted-N-1,3,4-thiadiazole-2-sulfonamide derivatives were synthesized in six-
steps. Esterification of 4-chlorobenzoic acid with methanol and subsequent
hydrazination, salt formation and cyclization afforded 5-(4-chlorophen-yl)-1,3,4-
thiadiazole-2-thiol (5). Conversion of this intermediate into sulfonyl chloride 6,
followed by nucleophilic attack of the amines gave the title sulfonamides 7a-7j
whose structures were confirmed by NMR, IR and elemental analysis. The bioassay
tests showed that compounds 7b and 7i possessed certain anti-tobacco mosaic virus
activity.},

DOI = {10.3390/molecules15129046}
}

@article{Andrea Scozzafava 2003

Title = Anticancer and Antiviral Sulfonamides
Journal = Current Medicinal Chemistry
volume = 10
Number = 11
Pages = 925-953
Year = 2003
ISSN = 0929-8673/1875-533X
DOI = 10.2174/0929867033457647
URL = http://www.eurekaselect.com/node/63717/article
Author = Andrea Scozzafava
Author = Takashi Owa
Author = Antonio Mastrolorenzo and Claudiu T. Supuran
Keywords = anticancer
Keywords = antiviral sulfonamides
Keywords = hypoglycemic
 Keywords = matrix metalloproteinase
Keywords = sulfonyl derivatives
Keywords = hiv protease inhibitors
Keywords = sulfonamido groups
Keywords = chemokine antagonists
Keywords = hiv entry inhibitors
Keywords = sulfonamide functionalities
Abstract = The sulfonamides constitute an important class of drugs, with several
types of pharmacological agents possessing antibacterial, anti- carbonic anhydrase,
diuretic, hypoglycemic and antithyroid activity among others. A large number of
structurally novel sulfonamide derivatives have ultimately been reported to show
substantial antitumor activity in vitro and in vivo. Although they have a common
chemical motif of aromatic / heterocyclic or amino acid sulfonamide, there are a
variety of mechanisms of their antitumor action, such as carbonic anhydrase
inhibition, cell cycle perturbation in the G1 phase, disruption of microtubule
assembly, functional suppression of the transcriptional activator NF-Y, and
angiogenesis (matrix metalloproteinase, MMP) inhibition among others. Some of these
compounds selected via elaborate preclinical screenings or obtained through
computer-based drug design, are currently being evaluated in clinical trials. The
review summarizes recent classes of sulfonamides and related sulfonyl derivatives
disclosed as effective tumor cell growth inhibitors, or for the treatment of
different types of cancer. Another research line that progressed much in the last
time regards different sulfonamides with remarkable antiviral activity. Thus, at
least two clinically used HIV protease inhibitors possess sulfonamide moieties in
their molecules, whereas a very large number of other derivatives are constantly
being synthesized and evaluated in order to obtain compounds with less toxicity or
activity against drug-resistant viruses. Several non nucleoside HIV reverse
transcriptase or HIV integrase inhibitors containing sulfonamido groups were also
reported. Another approach to inhibit the growth of retroviruses, including HIV,
targets the ejection of zinc ions from critical zinc finger viral proteins, which
has as a consequence the inhibition of viral replication in the absence of
mutations leading to drug resistance phenotypes. Most compounds with antiviral
activity possessing this mechanism of action incorporate in their molecules primary
sulfonamide groups. Some small molecule chemokine antagonists acting as HIV entry
inhibitors also possess sulfonamide functionalities in their scaffold.
}

@article{MUN20124590,

title = "Structure�activity relationship of 2,2-dimethyl-2H-chromene based

arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-
N-phenylbenzenesulfonamide, a novel small molecule hypoxia inducible factor-1 (HIF-
1) pathway inhibitor and anti-cancer agent",

journal = "Bioorganic & Medicinal Chemistry",

volume = "20",
number = "14",
pages = "4590 - 4597",

year = "2012",

issn = "0968-0896",
doi = "https://doi.org/10.1016/j.bmc.2012.04.064",
url = "http://www.sciencedirect.com/science/article/pii/S0968089612003823",

author = "Jiyoung Mun and Adnan Abdul Jabbar and Narra Sarojini Devi and Yuan Liu
and Erwin G. Van Meir and Mark M. Goodman",

keywords = "Hypoxia inducible factor-1, Small molecule HIF-1 transcription factor

inhibitors, Tumor hypoxia, 3,4-Dimethoxy--[(2,2-dimethyl-2-chromen-6-yl)methyl]--
phenylbenzenesulfonamide, Structure�activity relationships, Anti-cancer drugs,
Brain cancer",

abstract = "We have discovered that 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-

yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule HIF-1 pathway
inhibitor, can antagonize tumor growth in animal models of cancer, but the
treatment necessitates its delivery in a formulation, due to poor water solubility
(<15�g/mL; pH 7.4), evidencing that the chemotype needs further exploration of its
amenability to additional chemical modifications for ultimate optimization of
function and pharmacology. As a first step towards this goal we investigated the
structure�activity relationships of 15 lipophilic 2,2-dimethyl-2H-chromene based
arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-
N-phenylbenzenesulfonamide to find out strategies of modification. A 3,4-
dimethoxybenzenesulfonyl group in region 1 showed the strongest inhibition among
five arylsulfonyl groups tested. The presence of propan-2-amine in region 2
conferred the strongest inhibitory effect of the compound on HIF-1 activated
transcription in a reporter assay. These findings are important as they help define
the structural motifs where the 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-
yl)methyl]-N-phenylbenzenesulfonamide can be chemically modified to improve its
pharmacological properties towards development as a cancer therapeutic."
}