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The Nervous System
Overview

• nervous system and endocrine system


together perform a vital function for the
body- communication
• homeostasis and survival depend on this
function
• communication provides the means for
controlling and integrating the many
different functions performed by organs,
tissues and cells
Overview

• the nervous system is made up of brain,


spinal cord and nerves
• the nervous system is organized to detect
changes (stimuli) in the internal and
external environment evaluate information
and respond by initiating changes in
muscles or glands
The Nervous System
Two Anatomical Divisions
– Central nervous system (CNS)
• Brain
• Spinal cord
– Peripheral nervous system (PNS)
• All the neural tissue outside CNS
• Afferent division (sensory input)
• Efferent division (motor output)
– Somatic nervous system
– Autonomic nervous system
CENTRAL NERVOUS SYSTEM

Information
Processing

PERIPHERAL Sensory information Motor commands


NERVOUS within within
SYSTEM afferent division efferent division

includes

Somatic Autonomic
nervous nervous system
system

Parasympathetic Sympathetic
division division

Receptors Effectors

Smooth
muscle
Somatic sensory Visceral sensory Skeletal
receptors (monitor receptors (monitor Cardiac
muscle muscle
the outside world internal conditions
and our position and the status
in it) of other organ Glands
systems) Adipose
tissue

Figure 8-1
1 of 7
PERIPHERAL
NERVOUS
SYSTEM

Receptors

Somatic sensory Visceral sensory


receptors (monitor receptors (monitor
the outside world internal conditions
and our position and the status
in it) of other organ
systems)

Figure 8-1
2 of 7
PERIPHERAL Sensory information
NERVOUS within
SYSTEM afferent division

Receptors

Somatic sensory Visceral sensory


receptors (monitor receptors (monitor
the outside world internal conditions
and our position and the status
in it) of other organ
systems)

Figure 8-1
3 of 7
CENTRAL NERVOUS SYSTEM

Information
Processing

PERIPHERAL Sensory information


NERVOUS within
SYSTEM afferent division

Receptors

Somatic sensory Visceral sensory


receptors (monitor receptors (monitor
the outside world internal conditions
and our position and the status
in it) of other organ
systems)

Figure 8-1
4 of 7
CENTRAL NERVOUS SYSTEM

Information
Processing

PERIPHERAL Sensory information Motor commands


NERVOUS within within
SYSTEM afferent division efferent division

Receptors

Somatic sensory Visceral sensory


receptors (monitor receptors (monitor
the outside world internal conditions
and our position and the status
in it) of other organ
systems)

Figure 8-1
5 of 7
CENTRAL NERVOUS SYSTEM

Information
Processing

PERIPHERAL Sensory information Motor commands


NERVOUS within within
SYSTEM afferent division efferent division

includes

Somatic
nervous
system

Receptors Effectors

Somatic sensory Visceral sensory Skeletal


receptors (monitor receptors (monitor muscle
the outside world internal conditions
and our position and the status
in it) of other organ
systems)

Figure 8-1
6 of 7
CENTRAL NERVOUS SYSTEM

Information
Processing

PERIPHERAL Sensory information Motor commands


NERVOUS within within
SYSTEM afferent division efferent division

includes

Somatic Autonomic
nervous nervous system
system

Parasympathetic Sympathetic
division division

Receptors Effectors

Smooth
muscle
Somatic sensory Visceral sensory Skeletal
receptors (monitor receptors (monitor Cardiac
muscle muscle
the outside world internal conditions
and our position and the status
in it) of other organ Glands
systems) Adipose
tissue

Figure 8-1
7 of 7
Principal Functions of the Nervous System

• Responds to stimuli within the body and in


the external environment
• Transmits nerve impulses to and away
from the CNS
• Interprets nerve impulses arriving in the
cerebral cortex of the brain
• Assimilates experiences as required in
memory, learning and intelligence
Principal Functions of the Nervous System

• Initiates glandular secretion and muscle


contraction
• Programs instinctual behavoir (more
important in vertebrates other than
humans)
Nervous System

• a stimulus is an energy source (chemical,


pressure, light wave, etc.) that activates a
receptor cell (specialized nerve cell) to
transmit a nerve impulse or sensation

• if the sensation arrives in the conscious
part of the brain, the cerebral cortex, a
perception occurs.
Nervous System

• perception is awareness of the stimulus



Neural Tissue Organization
Two Classes of Neural Cells
– Neurons
• For information transfer, processing, and
storage
– Neuroglia
• Supporting framework for neurons
• Phagocytes
Neural Tissue Organization

Three Classes of Neurons


– Sensory neurons
• Deliver information to CNS
– Motor neurons
• Stimulate or inhibit peripheral tissues
– Interneurons (association neurons)
• Located between sensory and motor neurons
• Analyze inputs, coordinate outputs
Neural Tissue Organization

Neuron Anatomy
– Cell body
• Nucleus
• Mitochondria, RER, other organelles
– Dendrites
• Several branches
• Signal reception (inward)
– Axon
• Signal propagation (outward)
Neural Tissue Organization
The Anatomy of a
Representative Neuron

Figure 8-2
Neural Tissue Organization

Structural Classes of Neurons


– Unipolar
• Dendrite, axon continuous
• Afferent neurons
– Multipolar
• Many dendrites, one axon
• Most common class of neuron
– Bipolar
• One dendrite, one axon
• Very rare
Neuron Function
A Structural
Classification
of Neurons

Figure 8-3
Neural Tissue Organization

Types of Neuroglia (glia)


– Astrocytes
• Part of blood-brain barrier
– Oligodendrocytes
• Responsible for myelination
– Microglia
• Phagocytic defense cells
– Ependymal cells
• Lining of brain, spinal cord cavities
• Source of cerebrospinal fluid
Neural Tissue Organization
Neuroglia in the CNS

Figure 8-4
Neural Tissue Organization

Two Types of Neuroglia in the PNS
– Satellite cells
• Surround and support cell bodies
– Schwann cells
• Surround all peripheral axons
• Form myelin sheath on myelinated axons
• Support and insulate axons by forming
myelin, a substance composed of multiple
concentric layers of phospholipids
membrane
Neural Tissue Organization
Schwann Cells and Peripheral
Axons

Figure 8-5

Neural Tissue Organization

Neurons perform all of the
communication, information processing, and
control functions of the nervous system.

Neuroglia out number neurons and have
functions essential to preserving the physical
and biochemical structure of neural tissue and
the survival of neurons.
Neural Tissue Organization

Anatomic Organization of CNS Neurons


– Center—Collection of neurons with a shared
function
– Nucleus—A center with a discrete anatomical
boundary
– Neural cortex—Gray matter covering of brain
portions
– White matter—Bundles of axons (tracts) that
share origins, destinations, and functions
Neural Tissue Organization

Anatomic Organization of PNS Neurons


– Ganglia—Groupings of neuron cell bodies
– Nerve—Bundle of axons supported by
connective tissue
• Spinal nerves
– To/from spinal cord
• Cranial nerves
– To/from brain
Neural Tissue Organization
The Anatomical Organization of the Nervous
System Figure 8-6
Neural Tissue Organization

Pathways in the CNS


– Ascending pathways
Carry information from sensory receptors to
processing centers in the brain
– Descending pathways
Carry commands from specialized CNS
centers to skeletal muscles
Neuron Function

The Membrane Potential


– Resting potential
• Excess negative charge inside the
neuron
• Created and maintained by Na-K ion
pump
• Negative voltage (potential) inside
– -70 mV (0.07 Volts)
Neuron Function
The Cell Membrane at the
Resting Potential

Figure 8-7
Neuron Function
Changes in Membrane Potential
– Result from changes in ion movement
– Ions move in transmembrane channels
– Membrane channels can open or close
– If Na+ channels open ! positive charges enter
cell ! membrane potential moves positive
(depolarization)
– If K+ channels open ! positive charges leave
cell ! membrane potential moves negative
(hyperpolarization)
Neuron Function

Generation of Action Potential


– Depolarization of membrane to threshold
– Rapid opening of voltage-gated Na+ channels
– Na+ entry causes rapid depolarization
– Voltage-gated K+ channels open
– K+ exit causes rapid repolarization
– Refractory period ends as membrane recovers
the resting state
Activation of voltage-
Depolarization to threshold regulated sodium channels
and rapid depolarization

Sodium ions

Local
current

Potassium ions

Inactivation of sodium
channels and activation of
voltage-regulated
potassium channels

+30 DEPOLARIZATION REPOLARIZATION


3

0
Transmembrane potential (mV)

The return to normal


_ 60 Threshold permeability and resting state
_ 70 1
4

Resting
potential
REFRACTORY PERIOD

0 1 2 3
Time (msec)
Figure 8-8
1 of 5
Depolarization to threshold

Sodium ions

Local
current

+30 DEPOLARIZATION

0
Transmembrane potential (mV)

_ 60 Threshold

_ 70 1

Resting
potential

0 1 2 3
Time (msec)
Figure 8-8
2 of 5
Activation of voltage-
Depolarization to threshold regulated sodium channels
and rapid depolarization

Sodium ions

Local
current

Potassium ions

+30 DEPOLARIZATION

0
Transmembrane potential (mV)

_ 60 Threshold

_ 70 1

Resting
potential

0 1 2 3
Time (msec)
Figure 8-8
3 of 5
Activation of voltage-
Depolarization to threshold regulated sodium channels
and rapid depolarization

Sodium ions

Local
current

Potassium ions

Inactivation of sodium
channels and activation of
voltage-regulated
potassium channels

+30 DEPOLARIZATION REPOLARIZATION


3

0
Transmembrane potential (mV)

_ 60 Threshold

_ 70 1

Resting
potential

0 1 2 3
Time (msec)
Figure 8-8
4 of 5
Activation of voltage-
Depolarization to threshold regulated sodium channels
and rapid depolarization

Sodium ions

Local
current

Potassium ions

Inactivation of sodium
channels and activation of
voltage-regulated
potassium channels

+30 DEPOLARIZATION REPOLARIZATION


3

0
Transmembrane potential (mV)

The return to normal


_ 60 Threshold permeability and resting state
_ 70 1
4

Resting
potential
REFRACTORY PERIOD

0 1 2 3
Time (msec)
Figure 8-8
5 of 5

Neuron Function

“Information” travels within the
nervous system primarily in the form of
propagated electrical signals known as
action potentials.
The most important information (e.g.,
vision, balance, movement), is carried by
myelinated axons.
Neural Communication

Synapse Basics
– Intercellular communication
• Axon terminal
• Input to next cell
• Chemical signaling
– Neurotransmitter release
Neural Communication

Structure of a Synapse
– Presynaptic components
• Axon terminal
• Synaptic knob
• Synaptic vesicles
• Synaptic cleft
– Postsynaptic components
• Neurotransmitter receptors
Neural Communication

The Structure of a Typical Synapse

Figure 8-10
Neural Communication

Synaptic Function and Neurotransmitters


– Cholinergic synapses
• Release neurotransmitter acetylcholine
• Enzyme in synaptic cleft (acetylcholinesterase)
breaks it down
– Adrenergic synapses
• Release neurotransmitter norepinephrine
– Dopaminergic synapses
• Release neurotransmitter dopamine
An action potential arrives and Extracellular Ca2+ enters the synaptic
depolarizes the synaptic knob cleft triggering the exocytosis of ACh

PRESYNAPTIC Action potential


NEURON
Synaptic vesicles EXTRACELLULAR ACh
FLUID
ER
Synaptic Synaptic
knob Ca2+ cleft

Ca2+
AChE
Chemically regulated
POSTSYNAPTIC sodium channels
NEURON
CYTOSOL

ACh is removed by AChE ACh binds to receptors and depolarizes


(acetylcholinesterase) the postsynaptic membrane

Initiation of
action potential
Propagation of if threshold
action potential is reached
(if generated)

Na2+ Receptor
Na2+ Na2+ Na2+
Na2+
Figure 8-11
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 1 of 5
An action potential arrives and
depolarizes the synaptic knob

PRESYNAPTIC Action potential


NEURON
Synaptic vesicles EXTRACELLULAR
FLUID
ER
Synaptic
knob

AChE

POSTSYNAPTIC
NEURON
CYTOSOL

Figure 8-11
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 2 of 5
An action potential arrives and Extracellular Ca2+ enters the synaptic
depolarizes the synaptic knob cleft triggering the exocytosis of ACh

PRESYNAPTIC Action potential


NEURON
Synaptic vesicles EXTRACELLULAR ACh
FLUID
ER
Synaptic Synaptic
knob Ca2+ cleft

Ca2+
AChE
Chemically regulated
POSTSYNAPTIC sodium channels
NEURON
CYTOSOL

Figure 8-11
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 3 of 5
An action potential arrives and Extracellular Ca2+ enters the synaptic
depolarizes the synaptic knob cleft triggering the exocytosis of ACh

PRESYNAPTIC Action potential


NEURON
Synaptic vesicles EXTRACELLULAR ACh
FLUID
ER
Synaptic Synaptic
knob Ca2+ cleft

Ca2+
AChE
Chemically regulated
POSTSYNAPTIC sodium channels
NEURON
CYTOSOL

ACh binds to receptors and depolarizes


the postsynaptic membrane

Initiation of
action potential
if threshold
is reached

Na2+ Receptor
Na2+ Na2+ Na2+
Na2+
Figure 8-11
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 4 of 5
An action potential arrives and Extracellular Ca2+ enters the synaptic
depolarizes the synaptic knob cleft triggering the exocytosis of ACh

PRESYNAPTIC Action potential


NEURON
Synaptic vesicles EXTRACELLULAR ACh
FLUID
ER
Synaptic Synaptic
knob Ca2+ cleft

Ca2+
AChE
Chemically regulated
POSTSYNAPTIC sodium channels
NEURON
CYTOSOL

ACh is removed by AChE ACh binds to receptors and depolarizes


(acetylcholinesterase) the postsynaptic membrane

Initiation of
action potential
Propagation of if threshold
action potential is reached
(if generated)

Na2+ Receptor
Na2+ Na2+ Na2+
Na2+
Figure 8-11
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 5 of 5
Neural Communication

• Neuronal pools
Groups of interconnected neurons with
specific functions
• Divergence
Spread of information from one neuron to
several others
• Convergence
Several neurons send information to one
other
Neural Communication
Two Common Types of Neuronal Pools

Figure 8-12

Neural Communication

A synaptic terminal releases a neuro-
transmitter that binds to the postsynaptic cell
membrane. The result is a brief, local change in the
permeability of the postsynaptic cell.

Many drugs affect the nervous system by
stimulating neurotransmitter receptors and thus
produce complex effects on perception, motor
control, and emotions.
The Central Nervous System
Meninges—Layers that surround and protect
the brain and spinal cord (CNS)
– Dura mater (“tough mother”)
• Tough, fibrous outer layer
• Epidural space above dura of spinal cord
– Arachnoid (“spidery”)
• Subarchnoid space
• Cerebrospinal fluid
– Pia mater (“delicate mother”)
• Thin inner layer
The Central Nervous System
The Meninges

Figure 8-13(a)
The Central Nervous System
The Meninges

Figure 8-13(b)
The Central Nervous System

Spinal Cord Basics


– Relays information to/from brain
– Processes some information on its
own
– Divided into 31 segments
– Each segment has a pair of:
• Dorsal root ganglia
• Dorsal roots
• Ventral roots
– Gray matter appears as horns
– White matter organized into columns
The Central Nervous System
Gross Anatomy of
the Spinal Cord

Figure 8-14(a)
The Central Nervous System
Gross Anatomy of the Spinal Cord

Figure 8-14(b)
The Central Nervous System
Sectional Anatomy of the Spinal Cord

Figure 8-15(a)
The Central Nervous System
Sectional Anatomy of the Spinal Cord

Figure 8-15(b)
The Central Nervous System

The sensory and motor nuclei (gray matter) of
the spinal cord surround the central canal.
Sensory nuclei are dorsal, motor nuclei are
ventral. A thick layer of white matter consisting
of ascending and descending axons covers the
gray matter. These axons are organized into
columns of axon bundles with specific functions.
This highly organized structure often enables
predicting the impact of particular injuries.
The Central Nervous System

Brain Regions
– Cerebrum
– Diencephalon
– Midbrain
– Pons
– Medulla oblongata
– Cerebellum
The Central Nervous System
The Brain

Figure 8-16(a)
The Central Nervous System
The Brain

Figure 8-16(b)
The Central Nervous System
The Brain

Figure 8-16(c)
The Central Nervous System

Brain—The four hollow chambers in the


center of the brain filled with
cerebrospinal fluid (CSF)
– CSF produced by choroid plexus
– CSF circulates
• From ventricles and central canal
• To subarachoid space
– Accessible by lumbar puncture
• To blood stream
The Central Nervous System

The Ventricles of the Brain

Figure 8-17
The Central Nervous System

The Formation
and Circulation of
Cerebrospinal
Fluid

Figure 8-18(a)
The Central Nervous System
The Formation and Circulation of
Cerebrospinal Fluid

Figure 8-18(b)
The Central Nervous System

Functions of the Cerebrum


– Conscious thought
– Intellectual activity
– Memory
– Origin of complex patterns of movement
The Central Nervous System

Anatomy of Cerebral Cortex


– Highly folded surface
• Elevated ridges (gyri)
• Shallow depressions (sulci)
– Cerebral Hemispheres
• Longitudinal fissure
• Central sulcus
– Boundary between frontal and parietal lobes
• Other lobes (temporal, occipital)
The Central Nervous System

Functions of the Cerebral Cortex


– Hemispheres serve opposite body sides
– Primary motor cortex (precentral gyrus)
• Directs voluntary movement
– Primary sensory cortex (postcentral gyrus)
• Receives somatic sensation (touch, pain, pressure,
temperature)
– Association areas
• Interpret sensation
• Coordinate movement
The Central Nervous System
The Surface of the Cerebral Hemispheres

Figure 8-19
The Central Nervous System

Hemispheric Lateralization
– Categorical hemisphere (usually left)
• General interpretative and speech centers
• Language-based skills
– Representational Hemisphere (usually right)
• Spatial relationships
• Logical analysis
The Central Nervous System

Hemispheric
Lateralization

Figure 8-20
The Central Nervous System

The Basal Nuclei


– Lie deep within central white matter
of the brain
– Responsible for muscle tone
– Coordinate learned movements
– Coordinate rhythmic movements
(e.g., walking)
The Central Nervous System
The Basal Nuclei

Figure 8-22(a)
The Central Nervous System
The Basal Nuclei

Figure 8-22(b)
The Central Nervous System

Functions of the Limbic System


– Establish emotions and related drives
– Link cerebral cortex intellectual
functions to brain stem autonomic
functions
– Control reflexes associated with
eating
– Store and retrieve long-term
memories
The Central Nervous System
The Limbic System

Figure 8-23
The Central Nervous System
The Diencephalon
– Switching and relay center
– Integration of conscious and
unconscious motor and sensory
pathways
– Components include:
• Thalamus
• Hypothalamus
The Central Nervous System
The Diencephalon and Brain Stem

Figure 8-24(a)
The Central Nervous System

The Diencephalon
and Brain Stem

Figure 8-24(b)
The Central Nervous System

Functions of the Thalamus


– Relay and filter all ascending (sensory)
information
• Relay a small proportion to cerebral cortex
(conscious perception)
• Relay most to basal nuclei and brain stem
centers
– Coordinate voluntary and involuntary motor
behavior
The Central Nervous System

Functions of the Hypothalamus


– Produce emotions and behavioral drives
– Coordinate nervous and endocrine systems
– Secrete hormones
– Coordinate voluntary and autonomic
functions
– Regulate body temperature
The Central Nervous System

Anatomy and Function of the Brain Stem


– Midbrain
• Process visual, auditory information
• Generate involuntary movements
– Pons
• Links to cerebellum
• Involved in control of movement
– Medulla oblongata
• Relay sensory information
• Regulate autonomic function
The Central Nervous System

Anatomy and Function of the Cerebellum


– Oversees postural muscles
– Stores patterns of movement
– Fine tunes most movements
– Links to brain stem, cerebrum, spinal cord
• Communicates over cerebellar peduncles
The Central Nervous System

Functions of the Medulla Oblongata


– Links brain and spinal cord
– Relays ascending information to cerebral
cortex
– Controls crucial organ systems by reflex
• Cardiovascular centers
• Respiratory rhythmicity centers
The Central Nervous System


The brain, a large mass of neural tissue,
contains internal passageways and chambers
filled with CSF. The six major regions of the
brain have specific functions. As you ascend
from the medulla oblongata to the cerebrum,
those functions become more complex and
variable. Conscious thought and intelligence
are provided by the cerebral cortex.
The Peripheral Nervous System

PNS Basics
– Links the CNS with the body
– Carries all sensory information and motor
commands
– Axons bundled in nerves
– Cell bodies grouped into ganglia
– Includes cranial and spinal nerves
The Peripheral Nervous System

The Cranial Nerves


– 12 Pairs
• Connect to brain not the cord
– Olfactory (CN I)
• Sense of smell
– Optic (CN II)
• Sense of vision
– Oculomotor (CN III)
• Eye movement
The Peripheral Nervous System
The Cranial Nerves (continued)
– Trochlear (CN IV)
• Eye movement
– Trigeminal (CN V)
• Eye, jaws sensation/movement
– Abducens (CN VI)
• Eye movement
– Facial (CN VII)
• Face, scalp, tongue sensation/movement
– Vestibulocochlear (CN VIII)
• Hearing, balance
The Peripheral Nervous System

The Cranial Nerves (continued)


– Glossopharyngeal (CN IX)
• Taste, swallowing
– Vagus (CN X)
• Autonomic control of viscera
– Accessory (CN XI)
• Swallowing, pectoral girdle movement
– Hypoglossal (CN XII)
• Tongue movement
The Peripheral Nervous System
The Cranial Nerves

Figure 8-25(a)
The Peripheral Nervous System
The Cranial Nerves

Figure 8-25(b)
The Peripheral Nervous System


The 12 pairs of cranial nerves are
responsible for the special senses of smell,
sight, and hearing/balance, and control
movement of the eye, jaw, face, tongue,
and muscles of the neck, back, and
shoulders. They also provide sensation
from the face, neck, and upper chest and
autonomic innervation to thoracic and
abdominopelvic organs.
The Peripheral Nervous System

The Spinal Nerves


– 31 Pairs
• 8 Cervical
• 12 Thoracic
• 5 Lumbar
• 5 Sacral
– Dermatome—Region of the
body surface monitored by a pair
of spinal nerves
The Peripheral Nervous System

Nerve Plexus—A complex, interwoven


network of nerves
– Four Large Plexuses
• Cervical plexus
• Brachial plexus
• Lumbar plexus
• Sacral plexus
The Peripheral Nervous System
Peripheral
Nerves and
Nerve
Plexuses

Figure 8-26
The Peripheral Nervous System
Dermatomes

Figure 8-27
The Peripheral Nervous System

Reflex—An automatic involuntary motor


response to a specific stimulus
– The 5 steps in a reflex arc
• Arrival of stimulus and activation of receptor
• Activation of sensory neuron
• CNS processing of information
• Activation of motor neuron
• Response by effector (muscle or gland)
Dorsal Sensation
Arrival of Activation of a root relayed to
stimulus and sensory neuron the brain by
activation of collateral
receptor

REFLEX
Receptor ARC
Stimulus

Effector Ventral
root Information
processing
in CNS
Response Activation of a
by effector motor neuron
KEY
Sensory neuron
(stimulated)
Excitatory
interneuron
Motor neuron
(stimulated)

Figure 8-27
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 1 of 6
Arrival of
stimulus and
activation of
receptor

Stimulus

Figure 8-27
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 2 of 6
Dorsal
Arrival of Activation of a root
stimulus and sensory neuron
activation of
receptor

Receptor
Stimulus

KEY
Sensory neuron
(stimulated)

Figure 8-27
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 3 of 6
Dorsal Sensation
Arrival of Activation of a root relayed to
stimulus and sensory neuron the brain by
activation of collateral
receptor

Receptor
Stimulus

Information
processing
in CNS

KEY
Sensory neuron
(stimulated)
Excitatory
interneuron

Figure 8-27
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 4 of 6
Dorsal Sensation
Arrival of Activation of a root relayed to
stimulus and sensory neuron the brain by
activation of collateral
receptor

REFLEX
Receptor ARC
Stimulus

Ventral
root Information
processing
in CNS
Activation of a
motor neuron
KEY
Sensory neuron
(stimulated)
Excitatory
interneuron
Motor neuron
(stimulated)

Figure 8-27
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 5 of 6
Dorsal Sensation
Arrival of Activation of a root relayed to
stimulus and sensory neuron the brain by
activation of collateral
receptor

REFLEX
Receptor ARC
Stimulus

Effector Ventral
root Information
processing
in CNS
Response Activation of a
by effector motor neuron
KEY
Sensory neuron
(stimulated)
Excitatory
interneuron
Motor neuron
(stimulated)

Figure 8-27
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 6 of 6
The Peripheral Nervous System

Examples of Reflexes
– Monosynaptic reflex—Simplest reflex arc;
sensory neuron synapses directly on motor
neuron
– Stretch reflex—Monosynaptic reflex to regulate
muscle length and tension (example: patellar
reflex)
– Muscle spindle—Sensory receptor in a muscle
that stimulates the stretch reflex
Stretching of muscle tendon
stimulates muscle spindles
Muscle spindle
(stretch receptor)
Stretch

Spinal
cord
REFLEX
ARC

Contraction

Activation of motor
neuron produces reflex
muscle contraction
Figure 8-29
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 1 of 3
Stretching of muscle tendon
stimulates muscle spindles
Muscle spindle
(stretch receptor)
Stretch

Spinal
cord

Figure 8-29
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 2 of 3
Stretching of muscle tendon
stimulates muscle spindles
Muscle spindle
(stretch receptor)
Stretch

Spinal
cord
REFLEX
ARC

Contraction

Activation of motor
neuron produces reflex
muscle contraction
Figure 8-29
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 3 of 3
The Peripheral Nervous System

Polysynaptic reflex—A reflex arc with at


least one interneuron between the
sensory afferent and motor efferent
– Has a longer delay than a monosynaptic
reflex (more synapses)
– Can produce more complex response
– Example: flexor reflex, a withdrawal reflex
– Brain can modify spinal reflexes
The Peripheral Nervous System
The Flexor Reflex, a Type of Withdrawal
Reflex

Figure 8-30
The Peripheral Nervous System


Reflexes are rapid, automatic responses to
stimuli that “buy time” for the planning and
execution of more complex responses that
are often consciously directed.
The Peripheral Nervous System

Sensory Pathway
– Afferent axon signals from a sensory receptor
– Posterior column pathway
• Carries fine touch, pressure, proprioception
• Ascending neurons synapse in medulla oblongata
• Axons cross over and synapse in thalamus
• Thalamus sends axons to primary sensory cortex
• Organized as sensory homunculus
The Peripheral Nervous System

The Posterior Column


Pathway

Figure 8-31
The Peripheral Nervous System

Motor Pathways
– Corticospinal pathway (tract)
• Provides conscious muscle control
• Organized as motor homunculus
– Medial & lateral pathways (tract)
• Provide subconscious muscle control
The Peripheral Nervous System

The Corticospinal
Pathway

Figure 8-32
The Peripheral Nervous System

Table 8-4
The Autonomic Nervous System

Autonomic Nervous System


Branch of nervous system that
coordinates cardiovascular, digestive,
excretory, and reproductive functions
The Autonomic Nervous System
Anatomy of ANS
– Preganglionic neuron
• Cell body resides in CNS
• Axon synapses in PNS in autonomic ganglion
– Postganglionic axons (postganglionic
fibers) synapse on peripheral effectors
– Cardiac muscle
– Smooth muscle
– Glands
– Adipose tissues
The Autonomic Nervous System

Divisions of the ANS


– Sympathetic division
• Preganglionic neurons in the thoracic and lumbar
segments of the spinal cord
• “Fight or flight” system
– Parasympathetic division
• Preganglionic neurons in the brain and sacral
segments
• “Rest and digest” system
The Autonomic Nervous System


The two divisions of the ANS operate
largely without our awareness. The
sympathetic division increases alertness,
metabolic rate, and muscular abilities;
the parasympathetic division reduces
metabolic rate and promotes visceral
activities such as digestion.
The Autonomic Nervous System

The Somatic and


Autonomic Nervous
Systems

Figure 8-33(a)
The Autonomic Nervous System
The Somatic and
Autonomic Nervous
Systems

PLAY The Organization of


the Somatic and
Autonomic Nervous
System Figure 8-33(b)
The Autonomic Nervous System

Sympathetic Division Organization


– Preganglionic neurons in segments T1 to L2
– Ganglia near the vertebral column
– Sympathetic ganglia
• Paired sympathetic chain ganglia
• Unpaired collateral ganglia
– Preganglionic fibers to adrenal medullae
• Epinephrine (adrenalin) into blood stream
The Autonomic Nervous System
The Sympathetic Division

Figure 8-34
The Autonomic Nervous System

Effects of Sympathetic Activation


– Generalized response in crises
– Increased alertness
– Feeling of euphoria and energy
– Increased cardiovascular activity
– Increased respiratory activity
– Increased muscle tone
The Autonomic Nervous System

Parasympathetic Division Organization


– Preganglionic neurons in brain stem and
sacral spinal segment
– Ganglionic neurons (peripheral ganglia) in or
near target organ
– Sacral fibers form pelvic nerves
The Autonomic Nervous System
The Parasympathetic Division

Figure 8-35
The Autonomic Nervous System

Effects of Parasympathetic Activation


– Relaxation
– Food processing
– Energy absorption
– Brief effects at specific sites
The Autonomic Nervous System

Relationship between the Two Divisions


– Sympathetic division reaches visceral and
somatic structures throughout the body
– Parasympathetic division reaches only visceral
structures via cranial nerves or in the
abdominopelvic cavity
– Many organs receive dual innervation
• In general, the two divisions produce opposite
effects on the their target organs
Aging and the Nervous System

Age-Related Changes
– Reduction in brain size and weight
– Loss of neurons
– Decreased brain blood flow
– Changes in synaptic organization of the
brain
– Intracellular and extracellular changes in
CNS neurons

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