The Nervous System
Overview
Information
Processing
includes
Somatic Autonomic
nervous nervous system
system
Parasympathetic Sympathetic
division division
Receptors Effectors
Smooth
muscle
Somatic sensory Visceral sensory Skeletal
receptors (monitor receptors (monitor Cardiac
muscle muscle
the outside world internal conditions
and our position and the status
in it) of other organ Glands
systems) Adipose
tissue
Figure 8-1
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PERIPHERAL
NERVOUS
SYSTEM
Receptors
Figure 8-1
2 of 7
PERIPHERAL Sensory information
NERVOUS within
SYSTEM afferent division
Receptors
Figure 8-1
3 of 7
CENTRAL NERVOUS SYSTEM
Information
Processing
Receptors
Figure 8-1
4 of 7
CENTRAL NERVOUS SYSTEM
Information
Processing
Receptors
Figure 8-1
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CENTRAL NERVOUS SYSTEM
Information
Processing
includes
Somatic
nervous
system
Receptors Effectors
Figure 8-1
6 of 7
CENTRAL NERVOUS SYSTEM
Information
Processing
includes
Somatic Autonomic
nervous nervous system
system
Parasympathetic Sympathetic
division division
Receptors Effectors
Smooth
muscle
Somatic sensory Visceral sensory Skeletal
receptors (monitor receptors (monitor Cardiac
muscle muscle
the outside world internal conditions
and our position and the status
in it) of other organ Glands
systems) Adipose
tissue
Figure 8-1
7 of 7
Principal Functions of the Nervous System
Neuron Anatomy
– Cell body
• Nucleus
• Mitochondria, RER, other organelles
– Dendrites
• Several branches
• Signal reception (inward)
– Axon
• Signal propagation (outward)
Neural Tissue Organization
The Anatomy of a
Representative Neuron
Figure 8-2
Neural Tissue Organization
Figure 8-3
Neural Tissue Organization
Figure 8-4
Neural Tissue Organization
Two Types of Neuroglia in the PNS
– Satellite cells
• Surround and support cell bodies
– Schwann cells
• Surround all peripheral axons
• Form myelin sheath on myelinated axons
• Support and insulate axons by forming
myelin, a substance composed of multiple
concentric layers of phospholipids
membrane
Neural Tissue Organization
Schwann Cells and Peripheral
Axons
Figure 8-5
Neural Tissue Organization
Neurons perform all of the
communication, information processing, and
control functions of the nervous system.
Neuroglia out number neurons and have
functions essential to preserving the physical
and biochemical structure of neural tissue and
the survival of neurons.
Neural Tissue Organization
Figure 8-7
Neuron Function
Changes in Membrane Potential
– Result from changes in ion movement
– Ions move in transmembrane channels
– Membrane channels can open or close
– If Na+ channels open ! positive charges enter
cell ! membrane potential moves positive
(depolarization)
– If K+ channels open ! positive charges leave
cell ! membrane potential moves negative
(hyperpolarization)
Neuron Function
Sodium ions
Local
current
Potassium ions
Inactivation of sodium
channels and activation of
voltage-regulated
potassium channels
0
Transmembrane potential (mV)
Resting
potential
REFRACTORY PERIOD
0 1 2 3
Time (msec)
Figure 8-8
1 of 5
Depolarization to threshold
Sodium ions
Local
current
+30 DEPOLARIZATION
0
Transmembrane potential (mV)
_ 60 Threshold
_ 70 1
Resting
potential
0 1 2 3
Time (msec)
Figure 8-8
2 of 5
Activation of voltage-
Depolarization to threshold regulated sodium channels
and rapid depolarization
Sodium ions
Local
current
Potassium ions
+30 DEPOLARIZATION
0
Transmembrane potential (mV)
_ 60 Threshold
_ 70 1
Resting
potential
0 1 2 3
Time (msec)
Figure 8-8
3 of 5
Activation of voltage-
Depolarization to threshold regulated sodium channels
and rapid depolarization
Sodium ions
Local
current
Potassium ions
Inactivation of sodium
channels and activation of
voltage-regulated
potassium channels
0
Transmembrane potential (mV)
_ 60 Threshold
_ 70 1
Resting
potential
0 1 2 3
Time (msec)
Figure 8-8
4 of 5
Activation of voltage-
Depolarization to threshold regulated sodium channels
and rapid depolarization
Sodium ions
Local
current
Potassium ions
Inactivation of sodium
channels and activation of
voltage-regulated
potassium channels
0
Transmembrane potential (mV)
Resting
potential
REFRACTORY PERIOD
0 1 2 3
Time (msec)
Figure 8-8
5 of 5
Neuron Function
“Information” travels within the
nervous system primarily in the form of
propagated electrical signals known as
action potentials.
The most important information (e.g.,
vision, balance, movement), is carried by
myelinated axons.
Neural Communication
Synapse Basics
– Intercellular communication
• Axon terminal
• Input to next cell
• Chemical signaling
– Neurotransmitter release
Neural Communication
Structure of a Synapse
– Presynaptic components
• Axon terminal
• Synaptic knob
• Synaptic vesicles
• Synaptic cleft
– Postsynaptic components
• Neurotransmitter receptors
Neural Communication
Figure 8-10
Neural Communication
Ca2+
AChE
Chemically regulated
POSTSYNAPTIC sodium channels
NEURON
CYTOSOL
Initiation of
action potential
Propagation of if threshold
action potential is reached
(if generated)
Na2+ Receptor
Na2+ Na2+ Na2+
Na2+
Figure 8-11
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An action potential arrives and
depolarizes the synaptic knob
AChE
POSTSYNAPTIC
NEURON
CYTOSOL
Figure 8-11
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An action potential arrives and Extracellular Ca2+ enters the synaptic
depolarizes the synaptic knob cleft triggering the exocytosis of ACh
Ca2+
AChE
Chemically regulated
POSTSYNAPTIC sodium channels
NEURON
CYTOSOL
Figure 8-11
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An action potential arrives and Extracellular Ca2+ enters the synaptic
depolarizes the synaptic knob cleft triggering the exocytosis of ACh
Ca2+
AChE
Chemically regulated
POSTSYNAPTIC sodium channels
NEURON
CYTOSOL
Initiation of
action potential
if threshold
is reached
Na2+ Receptor
Na2+ Na2+ Na2+
Na2+
Figure 8-11
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 4 of 5
An action potential arrives and Extracellular Ca2+ enters the synaptic
depolarizes the synaptic knob cleft triggering the exocytosis of ACh
Ca2+
AChE
Chemically regulated
POSTSYNAPTIC sodium channels
NEURON
CYTOSOL
Initiation of
action potential
Propagation of if threshold
action potential is reached
(if generated)
Na2+ Receptor
Na2+ Na2+ Na2+
Na2+
Figure 8-11
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 5 of 5
Neural Communication
• Neuronal pools
Groups of interconnected neurons with
specific functions
• Divergence
Spread of information from one neuron to
several others
• Convergence
Several neurons send information to one
other
Neural Communication
Two Common Types of Neuronal Pools
Figure 8-12
Neural Communication
A synaptic terminal releases a neuro-
transmitter that binds to the postsynaptic cell
membrane. The result is a brief, local change in the
permeability of the postsynaptic cell.
Many drugs affect the nervous system by
stimulating neurotransmitter receptors and thus
produce complex effects on perception, motor
control, and emotions.
The Central Nervous System
Meninges—Layers that surround and protect
the brain and spinal cord (CNS)
– Dura mater (“tough mother”)
• Tough, fibrous outer layer
• Epidural space above dura of spinal cord
– Arachnoid (“spidery”)
• Subarchnoid space
• Cerebrospinal fluid
– Pia mater (“delicate mother”)
• Thin inner layer
The Central Nervous System
The Meninges
Figure 8-13(a)
The Central Nervous System
The Meninges
Figure 8-13(b)
The Central Nervous System
Figure 8-14(a)
The Central Nervous System
Gross Anatomy of the Spinal Cord
Figure 8-14(b)
The Central Nervous System
Sectional Anatomy of the Spinal Cord
Figure 8-15(a)
The Central Nervous System
Sectional Anatomy of the Spinal Cord
Figure 8-15(b)
The Central Nervous System
The sensory and motor nuclei (gray matter) of
the spinal cord surround the central canal.
Sensory nuclei are dorsal, motor nuclei are
ventral. A thick layer of white matter consisting
of ascending and descending axons covers the
gray matter. These axons are organized into
columns of axon bundles with specific functions.
This highly organized structure often enables
predicting the impact of particular injuries.
The Central Nervous System
Brain Regions
– Cerebrum
– Diencephalon
– Midbrain
– Pons
– Medulla oblongata
– Cerebellum
The Central Nervous System
The Brain
Figure 8-16(a)
The Central Nervous System
The Brain
Figure 8-16(b)
The Central Nervous System
The Brain
Figure 8-16(c)
The Central Nervous System
Figure 8-17
The Central Nervous System
The Formation
and Circulation of
Cerebrospinal
Fluid
Figure 8-18(a)
The Central Nervous System
The Formation and Circulation of
Cerebrospinal Fluid
Figure 8-18(b)
The Central Nervous System
Figure 8-19
The Central Nervous System
Hemispheric Lateralization
– Categorical hemisphere (usually left)
• General interpretative and speech centers
• Language-based skills
– Representational Hemisphere (usually right)
• Spatial relationships
• Logical analysis
The Central Nervous System
Hemispheric
Lateralization
Figure 8-20
The Central Nervous System
Figure 8-22(a)
The Central Nervous System
The Basal Nuclei
Figure 8-22(b)
The Central Nervous System
Figure 8-23
The Central Nervous System
The Diencephalon
– Switching and relay center
– Integration of conscious and
unconscious motor and sensory
pathways
– Components include:
• Thalamus
• Hypothalamus
The Central Nervous System
The Diencephalon and Brain Stem
Figure 8-24(a)
The Central Nervous System
The Diencephalon
and Brain Stem
Figure 8-24(b)
The Central Nervous System
The brain, a large mass of neural tissue,
contains internal passageways and chambers
filled with CSF. The six major regions of the
brain have specific functions. As you ascend
from the medulla oblongata to the cerebrum,
those functions become more complex and
variable. Conscious thought and intelligence
are provided by the cerebral cortex.
The Peripheral Nervous System
PNS Basics
– Links the CNS with the body
– Carries all sensory information and motor
commands
– Axons bundled in nerves
– Cell bodies grouped into ganglia
– Includes cranial and spinal nerves
The Peripheral Nervous System
Figure 8-25(a)
The Peripheral Nervous System
The Cranial Nerves
Figure 8-25(b)
The Peripheral Nervous System
The 12 pairs of cranial nerves are
responsible for the special senses of smell,
sight, and hearing/balance, and control
movement of the eye, jaw, face, tongue,
and muscles of the neck, back, and
shoulders. They also provide sensation
from the face, neck, and upper chest and
autonomic innervation to thoracic and
abdominopelvic organs.
The Peripheral Nervous System
Figure 8-26
The Peripheral Nervous System
Dermatomes
Figure 8-27
The Peripheral Nervous System
REFLEX
Receptor ARC
Stimulus
Effector Ventral
root Information
processing
in CNS
Response Activation of a
by effector motor neuron
KEY
Sensory neuron
(stimulated)
Excitatory
interneuron
Motor neuron
(stimulated)
Figure 8-27
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Arrival of
stimulus and
activation of
receptor
Stimulus
Figure 8-27
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Dorsal
Arrival of Activation of a root
stimulus and sensory neuron
activation of
receptor
Receptor
Stimulus
KEY
Sensory neuron
(stimulated)
Figure 8-27
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Dorsal Sensation
Arrival of Activation of a root relayed to
stimulus and sensory neuron the brain by
activation of collateral
receptor
Receptor
Stimulus
Information
processing
in CNS
KEY
Sensory neuron
(stimulated)
Excitatory
interneuron
Figure 8-27
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 4 of 6
Dorsal Sensation
Arrival of Activation of a root relayed to
stimulus and sensory neuron the brain by
activation of collateral
receptor
REFLEX
Receptor ARC
Stimulus
Ventral
root Information
processing
in CNS
Activation of a
motor neuron
KEY
Sensory neuron
(stimulated)
Excitatory
interneuron
Motor neuron
(stimulated)
Figure 8-27
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 5 of 6
Dorsal Sensation
Arrival of Activation of a root relayed to
stimulus and sensory neuron the brain by
activation of collateral
receptor
REFLEX
Receptor ARC
Stimulus
Effector Ventral
root Information
processing
in CNS
Response Activation of a
by effector motor neuron
KEY
Sensory neuron
(stimulated)
Excitatory
interneuron
Motor neuron
(stimulated)
Figure 8-27
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 6 of 6
The Peripheral Nervous System
Examples of Reflexes
– Monosynaptic reflex—Simplest reflex arc;
sensory neuron synapses directly on motor
neuron
– Stretch reflex—Monosynaptic reflex to regulate
muscle length and tension (example: patellar
reflex)
– Muscle spindle—Sensory receptor in a muscle
that stimulates the stretch reflex
Stretching of muscle tendon
stimulates muscle spindles
Muscle spindle
(stretch receptor)
Stretch
Spinal
cord
REFLEX
ARC
Contraction
Activation of motor
neuron produces reflex
muscle contraction
Figure 8-29
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 1 of 3
Stretching of muscle tendon
stimulates muscle spindles
Muscle spindle
(stretch receptor)
Stretch
Spinal
cord
Figure 8-29
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 2 of 3
Stretching of muscle tendon
stimulates muscle spindles
Muscle spindle
(stretch receptor)
Stretch
Spinal
cord
REFLEX
ARC
Contraction
Activation of motor
neuron produces reflex
muscle contraction
Figure 8-29
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings 3 of 3
The Peripheral Nervous System
Figure 8-30
The Peripheral Nervous System
Reflexes are rapid, automatic responses to
stimuli that “buy time” for the planning and
execution of more complex responses that
are often consciously directed.
The Peripheral Nervous System
Sensory Pathway
– Afferent axon signals from a sensory receptor
– Posterior column pathway
• Carries fine touch, pressure, proprioception
• Ascending neurons synapse in medulla oblongata
• Axons cross over and synapse in thalamus
• Thalamus sends axons to primary sensory cortex
• Organized as sensory homunculus
The Peripheral Nervous System
Figure 8-31
The Peripheral Nervous System
Motor Pathways
– Corticospinal pathway (tract)
• Provides conscious muscle control
• Organized as motor homunculus
– Medial & lateral pathways (tract)
• Provide subconscious muscle control
The Peripheral Nervous System
The Corticospinal
Pathway
Figure 8-32
The Peripheral Nervous System
Table 8-4
The Autonomic Nervous System
The two divisions of the ANS operate
largely without our awareness. The
sympathetic division increases alertness,
metabolic rate, and muscular abilities;
the parasympathetic division reduces
metabolic rate and promotes visceral
activities such as digestion.
The Autonomic Nervous System
Figure 8-33(a)
The Autonomic Nervous System
The Somatic and
Autonomic Nervous
Systems
Figure 8-34
The Autonomic Nervous System
Figure 8-35
The Autonomic Nervous System
Age-Related Changes
– Reduction in brain size and weight
– Loss of neurons
– Decreased brain blood flow
– Changes in synaptic organization of the
brain
– Intracellular and extracellular changes in
CNS neurons