Functions of Blood
• Transport of gases, nutrients and waste products
• Clot formation
Characteristics of Blood
• Type of connective tissue
• Sticky
Composition of Blood
• Plasma:
• Formed Elements:
Plasma Proteins
• Albumin:
• Globulins:
• Fibrinogen:
- 4% of plasma proteins
Erythrocytes
• Red blood cells (RBC)
• Function:
transport O2 to tissues
Hemoglobin
• Main component of erythrocytes
• Transports O2
• O2 binds to iron
• Oxyhemoglobin:
Production of Erythrocytes
1. Decreased blood O2 levels cause kidneys to increase production of erythropoietin.
• Bilirubin is taken up by liver and released into small intestine as part of bile
Leukocytes
• White blood cells (WBC)
• Lack hemoglobin
• Contain a nucleus
• Functions:
- fight infections
Types of Leukocytes
• Granulocytes
contain granules
1. Neutrophils:
- most common
- phagocytes
2. Eosinophils:
reduce inflammation
3. Basophils:
- least common
• Agranulocytes
no granules
1. Monocytes :
- largest
- produce macrophages
2. Lymphocytes:
- immune response
Platelets
• What are they?
Hematopoiesis
• What is it?
• In an infant, occurs in liver, thymus gland, spleen, lymph nodes, and red bone marrow.
• Stem cell:
Blood Loss
• When blood vessels are damaged, blood can leak into other tissues and disrupt normal function.
2. Platelet plugs:
Blood Clotting
• Blood can be transformed from a liquid to a gel
• Clot:
- network of thread-like proteins called fibrin that trap blood cells and fluid
• Clotting factors:
- proteins in plasma
- made in liver
- require vitamin K
• Anticoagulants:
- condensing of clot
• Fibrinolysis:
Blood Reactions
• Injury or surgery can lead to a blood transfusion
• Transfusion reactions/Aggulination:
• Antigens:
• Antibodies:
proteins in plasma
• Blood groups:
Rh Blood Group
• Rh positive means you have Rh antigens
• Antibodies only develop if an Rh- person is exposed to Rh+ blood by transfusion or from
mother to fetus
Example of Rh Reaction
• If mother is Rh- and fetus is Rh+ the mother can be exposed to Rh+ blood if fetal blood leaks
through placenta and mixes with mother’s blood.
• First time this occurs mother’s blood produces antibodies against antigens.
- occurs when mother produces anti-Rh antibodies that cross placenta and agglutination and
hemolysis of fetal erythrocytes occurs
- prevented if mother is treated with RhoGAM which contains antibodies against Rh antigens
provides information such as RBC count, hemoglobin, hematocrit, and WBC count
• Hematocrit:
• Hemoglobin:
- indicate anemia
• Prothrombin time:
- neutrophils: 60-70%
- lymphocytes: 20-25%
- monocytes: 3-8%
- eosinophils: 2-4%
- basophils: 0.5-1%
• Leukocytosis: