Cardio

Heart Failure cells Chronic congestions (lungs, liver, heart) Hemosiderin laden
macrophages
Lines of Zahn Arterial thrombosis Laminations composed
of pale platelet and
fibrin deposits
alternating with dark or
red cell-rich layers; ante-
mortem thrombosis
LE (Lupus SLE Neutrophil, phagocytized
Erythematosus) cell Tart Lymphoblastoma/metastatic Same as LE and digested the nuclei
Cell carcinoma cell but of another cell
with intact
chromatin
Foam cells Atherosclerosis Oxidized lipoproteins
accumulated in
macrophages in smooth
muscle cells
Fatty streak Atherosclerosis Multiple fat yellow spots
coalescing into streaks.
Lipid-filled foamy
macrophages in intima
Aschoff bodies Rheumatic fever Granulomatous
structures with fibrinoid
tissue; lymphocytic
infiltrates; occasional
plasma cells with
characteristics
macrophages around a
necrotic center
sometimes fusing to
form giant cells
Caterpillar cells Rheumatic fever Plump activated
Anitschkow cellls macrophages, abundant
cytoplasm with round to
ovoid nuclei and
condensed chromatin
slender wave pattern
Spider cells Rhabdomyoma Thin strands of
cytoplasm that stretch
from the nucleus to the
surface membrane
Myxoma cells Myxoma Moderately cellular
bland spindles and
stellate cells in a
muscopolysaccharide
matrix
Hemaonco
Russel Bodies Multiple Myeloma
Auer rods AML
Acute Promyelocytic Leukemia
Faggot cells AML
Acute Promyelocytic Leukemia
Smudge cells Chronic lymphocytic leukemia
Basket Cells Small lymphocytic leukemia
Reed Sternberg cells Hodgkins Lymphoma
Starry sky pattern Burkitt Lymphoma
Dutcher bodies Multiple Myeloma
Waldenstroms
macroglobulinemia
Ringed Sideroblasts Myelodysplastic syndrome
(erythroid)
Pseudo-Pelget Huet cells Myelodysplastic syndrome
(granulocytic)
Pawnball megakaryocytes Myelodysplastic syndrome
(megakaryocytic)
Spherocytes Hereditary spherocytosis
Heinz bodies Glucose 6 phosphate
Heinz-Ehrlich bodies dehydrogenase deficiency
Degmacytes Glucose 6 phosphate
dehydrogenase deficiency
Drepanocytes Sickle cell disease
Sickle cells
Codocytes Sickle cell disease
Target cells
Eosinophilic large
homogeneous Ig
containing inclusions
found in plasma cells,
excessive synthesis of Ig
Needle like azurophilic granules
Cells with numerous Auer rods
Remnants of cells without
identifiable cytoplasm
membrane or nucleus fragile
lymphocytes
Large multiple nuclei or single
with multiple lobes each lobe
with a nucleolus (‘owls eye
nucleus’)
Diffuse infiltration of medium
size anaplastic lymphocytes
(sky) punctuated with
macrophages that phagocytose
lymphocytes (stars)
Intracytoplasmic inclusions that
are invaginated into the nucleus
(Looks intranuclear)
Prussian blue (+) iron laden
mitochondria in erythroblasts
PMNs with only 2 lobes normal
is 3-5
Megakaryocytes with multiple
separated nuclei
Round erythrocytes without
central pallor
Inclusions in erythrocytes
composed of denatured
hemoglobin seen in supravital
staining
Erythrocytes with one or more
semicircular portions bitten off
the cell margin
Sickle cell shaped erythrocytes
Erythrocytes with a dark center
and white ring followed by an
outer red ring with Hgb
(dehydrated erythrocytes)
Howell-Jolly bodies Sickle cell disease Basophilic nuclear remnants in
circulating erythrocytes
(erythrocytes usually don’t have
nuclei)

Genitourinary/Reproductive
Michaelis Gutman bodies Malakoplakia Rounded concentrically layered
intracytoplasmic inclusions
Denuding cystitis Flat urothelial Cancer Malignant cells on a largely
Bladder carcinoma in situ denuded basement membrane
with influenced hyperemic
stroma
Schiller duval bodies Yolk sac tumor Central blood vessel
encapsulated by tumor cells
within a space lined by a tumor
cell
Reinke Crystals Leydig cell tumor Plasma rod like cytoplasmic
inclusions
Call-exner bodies Granulose call tumor Small cuboidal to polygonal cells
in sheets, cords; may
recapitulate gland like
structures with central
acidophilic material
Paget cells Paget disease Large cells with clear cytoplasm
and eccentric hyperchromic
nuclei; seen at the epidermis

Pulmo
Curshmann spirals Bronchial Asthma Spiral shaped mucous plugs
from sub epithelial mucous
gland ducts of bronchi
Charcot-Leyden crystals Bronchial Asthma Eosinophil protein galectin,
found in people who have
allergic disease
Schaumann bodies Sarcoidosis Calcium and protein inclusions
inside of Langhans giant cells as
part of a granuloma
Asteroid bodies Sarcoidosis Stellate inclusions within giant
cells of granulomas

Endocrine
Salt and pepper chromatin Neuroendocrine tumors Salt and pepper nuclei and
Medullary thyroid ca stippled chromatin, granular
Pheochromocytoma chromatin
Small cell lung cancer
 Paraganglioma
Zellballen Paraganglioma Small nest of chromaffin cells or
Pheochromocytoma chief cells with pale eosinophilic
staining separated by bands of
fibrovascular stroma
surrounded by support
sustentacular cells
Hurthle cell Hashimoto thyroiditis Oncocytic cells in thyroid tissue;
Hurthle cell cancer Cellular enlargement with
Thyroid adenoma abundant eosinophilic granular
Thyroid follicular cancer cytoplasm as a result of
accumulation of altered
mitochondria
Zebra bodies Niemann-Pick disease Type A Membranous cytoplasmic
and Type B inclusions of lamellated myelin
figures
Gaucher cells Gaucher disease Distended phagocytic cells in
(glucocerebrosidase deficiency) spleen, liver, bone marrow,
lymph nodes, tonsils, thymus
and peyer patches (Lymphoid
tissue) with fibrillary cytoplasm;
crumpled tissue appearance
Psammoma bodies Papillary thyroid cancer Sand-like lamellated
Papillary renal cancer concentration
Meningioma
Crooke hyaline change Cushing syndrome Homogenous paler cytoplasm of
ACTH secreting cells

Derma
Munro microabscesses Psoriasis Neutrophils within the
parakeratotic stratum corneum
Spongiform pustules of Kogoj Psoriasis Neutrophils in spongiotic foci of
the superficial epidermis
Horn cysts Seborrheic keratoses Small keratin filled cysts
Civatte bodies Lichen Planus Anucleate, necrotic basal cells in
inflamed papillary dermis

Neuro
Kuru Plaques Creutzfeld Jakob Extracellular deposits of
Kuru aggregated abnormal proteins
Lewy body Parkinsons disease Abnormal aggregates of alpha-
Lewy Body dementia synuclein protein
Bunina bodies Amytrophic lateral sclerosis PAS (+) small eosinophilic
intraneuronal inclusions in the
remaining lower motor neurons
Rosenthal fibers
Homer wright psuedorosettes
Flexner-wintersteiner Rosettes
Infectious
Halberstaedter prowazek
bodies
Clue Cells
Downey Cells
Guarnieri bodies
Henderson-Patterson Bodies
Negri bodies
Sezary cells
Pautrier microabscesses
Warthin-Finkeldey cells
Cowdry Type A
Pilocytic astrocytoma Thick elongated worm like
Chronic gliosis corkscrew eosinophilic bundle
on H&E stain of the brainF
Neuroblastoma Small round cells around a
Ewing Sarcoma central space filled with
Medulloblastoma eosinophilic fibrillary material
Retinoblastoma Tumor cells surrounding a
lumen of cytoplasmic
extensions
Trachoma Scraping the conjunctiva shows
C. trachomatis round to oval intracytoplasmic
inclusions within conjunctival
epithelial cells
Gardnerella vaginalis Vaginal squamous epithelial
cells coated with the anaerobic
gram-variable coccobacilli
Epstein Barr virus CD8+ T-cells increase in
Infectious Mononucleosis numbers in the blood stream
and are activated (atypicial
presence of reactive
lymphocytes in peripheral
blood)
Variola Virus B-type inclusions found in cells
Small Pox stained with eosin, appear as
pink blobs in the cytoplasm of
affected epithelial cells
Molluscum contangiosum Lobules containing hyalinized
molluscum bodies;
intracytoplasmic inclusion body
Rabies Cytoplasmic round to oval
eosinophilic inclusions in
pyramidal neurons of the
hippocampus and Purkinje cells
of the cerebellum
Mycosis Fungoides T cells with cerebriform nuclei,
Cutaneous T Cell Lymphoma Increased mucopolysaccharides
Mycosis Fungoides Accumulation of Sezary cells in
Cutaneous T Cell Lymphoma the epidermis
Measles (Rubeola virus) Multinucleated giant cells with
eosinophilic nuclear and
cytoplasmic inclusions (in lymph
nodes, lung and sputum)
Herpes Simplex Virus Eosinophilic or Basophilic
inclusions of nucleic acid and

Owls Eye
Fleur de lis pattern
Donovan bodies
Lepra cells
Gumma
Durck granulomas
Nurse cells
Meyers kouwenaar bodies
Morula Cells of Mott
Langhans type giant cell
Pirogov-Langhans giant cell
Gastrointestinal
Signet ring cell
Cytomegalovirus
Hodgkins Lymphoma
Pseudomonas
Donovanosis
Granuloma inguinale
Klebsiella granulomatis
Lepromatous Leprosy
Syphilis (tertiary stage)
Malaria
Trichinosis
Lymphatic filariasis
Trypanosoma Brucei
Sleeping sickness
Granulomatous conditions
Mycobacterium tuberculosis
Basta Malala ito hahaha
Diffuse infiltrative
gastroadenocarcinoma (linitis
plastica)
protein with intact and
disrupted virons
Intranuclear basophilic
inclusions surrounded by a clear
halo
Pale necrotic centers with red
hemorrhagic periphery
Gram negative rod shaped oval
organisms in the cytoplasm of
mononuclear phagocytes;
safety pin appearance
Macrophages with foamy
cytoplasm (lipids), poorly
staining sac like structures, globi
(AFB)
Central coagulation necrosis
surrounded by palisading
macrophages and fibroblasts
plasma cell-rich infilitrate; lower
number of treponemes (higher
in secondary)
Rarefied brain tissue containing
activated microglial cells at a
site of prior perivascular ring
hemorrhages
Skeletal muscle cells without
striations
Eosinophilic precipitates
embedded in small epithelioid
granulomas
Atypical plasma cells with
comparments visible in the
cytoplasm; Immunoglobulins
that haven’t been released
Fusion of epithelioid cells
(macrophages), and contain
nuclei arranged in a horseshoe-
shaped pattern in the cell
periphery
Cells with a large vacuoles filled
with mucin
 Highly malignant forms of
epithelial cancers of the
bladder, colorectal, breast and
ovarian stroma
Councilman bodies Chronic viral hepatitis
Councilman hyaline bodies
Apoptotic bodies
Hepatitis rosette Autoimmune hepatitis
Mallory- Denk Body Alcoholic steatohepatitis
Mallory body Primary Billiary cirrhosis
Mallorys hyaline
Rokitansky Aschoff sinuses Chronic cholecystitis
adenomyomatosis
Nephrology
Spike and dome appearance Membranous nephropathy
Tram track sign Membranoproliferative
glomerulonephritis
Basket weave appearance Alport syndrome
(inherited type IV collagen
defect)
Coffin lid crystals Struvite calculi
Octahedron crystals Calcium oxalate calculi
Rhombic crystals Uric acid calculi
Hexagonal crystals Cystine calculi
Acidophilic globule of cells;
dying hepatocyte surrounded
by normal parenchyma
Small group of surviving
hepatocytes within areas of
collapse
Clumped amorphous
eosinophilic inclusions in the
cytoplasm with damaged
intermediary filaments
Intramural diverticula or sinus
tracts in the gallbladder
Subepithelial deposits in
glomerular basement
membrane with effacement of
foot processes; seen on
electron microscopy
Thickened, split glomerular
basement membrane; seen on
electron microscope
Irregular thickening of the
glomerular basement
membrane in the late stages;
seen on electron microscopy