TRUTH, EXCELLENCE, SERVICE

VALLESTEROS, Nikolas Adonar M. 14 AUG 2019

11 G Topic Proposal

Cellulose-based Hydrogel Infused with Povidone Iodine as an

Alternative Wound Dressing Material
Background of the Study

Povidone Iodine has been used as an instrument for wound healing and has been proven effective.
Since almost all wounds contain microorganisms which may have the risk of infecting a person’s wound,
Povidone Iodine’s antimicrobial properties makes it a good antispetic in healing wounds (Bigliardi et al.,
2017).

A study of carboxymethyl cellulose, polyvinyl alcohol, and gelatin crosslinked by polyacrymalide

hydrogels loaded with Povidone Iodine has already been conducted by Mishra and Chaudhary in 2010
where they found out that their dressings offer similar reults to a normal antiseptic but hydrogels are
painless and is not inflammatory. No research has been done yet to explore on just cellulose-based
hydrogels which are made from cellulose derivatives.

Mishra and Chaudhary discussed in their results that the addition of carboxymethyl cellulose in
their hydrogels increased the release of Povidone Iodine in their subjects. This is because all cellulose
based hydrogels are hydrophilic polymers which means they have high water sorption that leads to
increased release of Povidone Iodine.

The most abundant bipolymer on Earth is cellulose. Cellulose-based hydrogels can store large
amounts of water due to its high absorbption rate and it has been used in the biomedical field for a long
while already (Kabir et al., 2018). Cellulose has a great biodegradability and biocompatibilty which means
it would not be harmful for the environment and humans compared to the other polymers used for
hydrogels (Ciolacu & Suflet, 2018). It is also mechanically robust which means it does not easily break
(Ciolacu & Suflet, 2018).

Objectives of the Study

This project aims to determine the feasibility of cellulose based hydrogel infused with Povidone
Iodine as an alternative wound dressing material.

The project also seeks to determine the right amount of each type of cellulose for a hydrogel.
Significance of the Study

This would have a significant contribution to the researches in wound healing, particularly in
product development. The results in this study may also open up opportunities for more researches on
callulose-based hydrogels in this branch of research. The effect of the hydrogels as dressings if to be
proven beneficial may inspire other researchers to produce more patches made up of hydrogels.

Research Design

Experimental Unit

Cellulose based hydrogels will be made using different kinds of cellulose derivatives as
treatmets. All hydrogels will be mixed in distilled water in the same weight by volume amount
and will be crosslinked with the same compund. All of them will be mixed in a magnetic stirrer in
the same amount of time. The same amount of each hydrogel will be put in same sizes of petri
dishes.

Treatments

Three kinds of cellulose derivatives will be used for this study: Carboxymethyl cellulose
(CMC), Hydroxypropyl cellulose (HPC), and Hydroxypropylmethyl cellulose (HPMC). For positive
control, commercially available cotton will be used to absorb and release Povidone Iodine. Each
treatment will be replicated three times.

Level 0 Flowchart

Preparation Procurement of
of Hydrogels Povidone Iodine

Loading of Povidone
Iodine into the Hydrogels

Testing of
Hydrogels
References

Bigliardi, P. L., Alsagoff, S. A., El-Kafrawie, H. Y., Pyong, J.-K., Wa, C. T., & Villa, M. A. (2017). Povidone
iodine in wound healing: A review of current concepts and practices. International Journal of
Surgery, 44, 260-268.

Ciolacu, D. E., & Suflet, D. M. (2018). Cellulose-Based Hydrogels for Medical/Pharmaceutical

Applications. Biomass as Renewable Raw Material to Obtain Bioproducts of High-Tech Value,,
Cellulose-Based Hydrogels for Medical/Pharmaceutical Applications.

Kabir, S. M., Sikdar, P. P., Haque, B., Bhuiyan, M. A., Ali, A., & Islam, M. N. (2018). Cellulose-based
hydrogel materials: chemistry, properties and their prospective applications. Progress in
Biomaterials, 153–174.

Mishra, A., & N. C. (2010). Study of Povidone Iodine Loaded Hydrogels as Wound Dressing Material.
Trends in Biomaterials and Artificial Organs, 122- 128.