eCollection 2017.
Lee CH(1)(2), Chang FC(1), Hsu SD(3), Chi HY(4), Huang LJ(5), Yeh MK(6).
Author information:
(1)Department of Health Promotion and Health Education, National Taiwan Normal
University, Taipei, Taiwan, ROC.
(2)Department of Pharmacy Practice, Tri-Service General Hospital, National
Defense Medical Center, Taipei, Taiwan, ROC.
(3)Division of General Surgery, Department of Surgery, Tri-Service General
Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
(4)Department of Health Developing and Marketing, Kainan University, Taoyuan,
Taiwan, ROC.
(5)Chia Nan University of Pharmacy and Science, Tainan, Taiwan, ROC.
(6)Ministry of Health and Welfare, Taipei, Taiwan, ROC.
DOI: 10.1371/journal.pone.0189199
PMCID: PMC5730183
PMID: 29240799 [Indexed for MEDLINE]
Ayalew MB(1).
Author information:
(1)Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and
Health Sciences, University of Gondar, Gondar, Ethiopia.
DOI: 10.2147/PPA.S131496
PMCID: PMC5338978
PMID: 28280312
Self-medication and its risk factors among women before and during pregnancy.
Author information:
(1)Center for Health Related Social and Behavioral Sciences Research, Shahroud
University of Medical Sciences, Shahroud, Iran.
(2)Department of Midwifery, School of Nursing & Midwifery, Shahroud University of
Medical Sciences, Shahroud, Iran.
(3)Department of Epidemiology and Biostatistics, School of Public Health,
Shahroud University of Medical Sciences, Shahroud, Iran.
DOI: 10.11604/pamj.2017.27.183.10030
PMCID: PMC5579420
PMID: 28904710 [Indexed for MEDLINE]
Mortazavi SS(1), Shati M(2), Khankeh HR(3)(4), Ahmadi F(5), Mehravaran S(6),
Malakouti SK(7).
Author information:
(1)Mental Health Research Center, Tehran Institute of Psychiatry-School of
Behavioral Sciences and Mental Health, Iran University of Medical Sciences,
Tehran, Iran.
(2)Department of Aging, University of Social Welfare & Rehabilitation Sciences,
Tehran, Iran.
(3)University of Social Welfare & Rehabilitation Sciences, Tehran, Iran.
(4)Department of Clinical Science and Education, Karolinska Institutet,
Stockholm, Sweden.
(5)Department of Nursing, Faculty of Medical Sciences, Tarbiat Modarres
University, Tehran, Iran.
(6)Department of Ophthalmology, Stein Eye Institute, David Geffen School of
Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
(7)Mental Health Research Center, Tehran Institute of Psychiatry-School of
Behavioral Sciences and Mental Health, Iran University of Medical Sciences,
Tehran, Iran. malakoutik@gmail.com.
DOI: 10.1186/s12877-017-0596-z
PMCID: PMC5580436
PMID: 28863775 [Indexed for MEDLINE]
Arrais PS(1), Fernandes ME(1), Pizzol TD(2), Ramos LR(3), Mengue SS(4), Luiza
VL(5), Tavares NU(6), Farias MR(7), Oliveira MA(5), Bertoldi AD(8).
Author information:
(1)Departamento de Farmácia. Faculdade de Farmácia, Odontologia e Enfermagem.
Universidade Federal do Ceará. Fortaleza, CE, Brasil.
(2)Departamento de Produção e Controle de Medicamentos. Faculdade de Farmácia.
Universidade Federal do Rio Grande do Sul. Porto Alegre, RS, Brasil.
(3)Departamento de Medicina Preventiva. Escola Paulista de Medicina. Universidade
Federal de São Paulo. São Paulo, SP, Brasil.
(4)Departamento de Medicina Social. Universidade Federal do Rio Grande do Sul.
Porto Alegre, RS, Brasil.
(5)Departamento de Política de Medicamentos e Assistência Farmacêutica. Escola
Nacional de Saúde Pública Sérgio Arouca. Fundação Oswaldo Cruz. Rio de Janeiro,
RJ, Brasil.
(6)Departamento de Farmácia. Faculdade de Ciências da Saúde. Universidade de
Brasília. Brasília, DF, Brasil.
(7)Departamento de Ciências Farmacêuticas. Centro de Ciências da Saúde.
Universidade Federal de Santa Catarina. Florianópolis, SC, Brasil.
(8)Departamento de Medicina Social. Faculdade de Medicina. Universidade Federal
de Pelotas. Pelotas, RS, Brasil.
OBJECTIVE: To analyze the prevalence and associated factors regarding the use of
medicines by self-medication in Brazil.
METHODS: This cross-sectional population-based study was conducted using data
from the PNAUM (National Survey on Access, Use and Promotion of Rational Use of
Medicines), collected between September 2013 and February 2014 by interviews at
the homes of the respondents. All people who reported using any medicines not
prescribed by a doctor or dentist were classified as self-medication
practitioners. Crude and adjusted prevalence ratios (Poisson regression) and
their respective 95% confidence intervals were calculated in order to investigate
the factors associated with the use of self-medication by medicines. The
independent variables were: sociodemographic characteristics, health conditions
and access to and use of health services. In addition, the most commonly consumed
medicines by self-medication were individually identified.
RESULTS: The self-medication prevalence in Brazil was 16.1% (95%CI 15.0-17.5),
with it being highest in the Northeast region (23.8%; 95%CI 21.6-26.2). Following
the adjusted analysis, self-medication was observed to be associated with
females, inhabitants from the North, Northeast and Midwest regions and
individuals that have had one, or two or more chronic diseases. Analgesics and
muscle relaxants were the therapeutic groups most used for self-medication, with
dipyrone being the most consumed medicines. In general, most of the medicines
used for self-medication were classified as non-prescriptive (65.5%).
CONCLUSIONS: Self-medication is common practice in Brazil and mainly involves the
use of non-prescription medicines; therefore, the users of such should be made
aware of the possible risks.
OBJETIVO: Analisar a prevalência e os fatores associados à utilização de
medicamentos por automedicação no Brasil.
MÉTODOS: Este estudo transversal de base populacional foi realizado com dados da
Pesquisa Nacional de Acesso, Utilização e Promoção do Uso Racional de
medicamentos (PNAUM), coletados de setembro de 2013 a fevereiro de 2014, por meio
de entrevistas em domicílio. Todas as pessoas que referiram usar qualquer
medicamento sem prescrição por médico ou dentista foram classificadas como
praticantes de automedicação. Foram calculadas razões de prevalência bruta e
ajustada (regressão de Poisson) e seus respectivos intervalos de confiança de 95%
na investigação dos fatores associados ao consumo de medicamentos por
automedicação. As variáveis independentes foram: aspectos sociodemográficos, de
condições de saúde e de acesso e utilização de serviços de saúde. Adicionalmente,
foram identificados os medicamentos mais consumidos por automedicação.
RESULTADOS: A prevalência da automedicação no Brasil foi de 16,1% (IC95%
15,0-17,5), sendo maior na região Nordeste (23,8%; IC95% 21,6-26,2). Após análise
ajustada, automedicação mostrou-se associada a ser do sexo feminino, pertencer às
faixas etárias 10-19 anos, 20-29 anos, 40-59 anos e 60 anos ou mais, residir na
região Norte, Nordeste ou Centro-Oeste, e ter uma ou duas ou mais doenças
crônicas. Os analgésicos e os relaxantes musculares foram os grupos terapêuticos
mais utilizados por automedicação, sendo a dipirona o fármaco mais consumido. No
geral, a maioria dos medicamentos usados por automedicação foram classificados
como isentos de prescrição (65,5%).
CONCLUSÕES: A automedicação é prática corrente no Brasil e envolve,
principalmente, o uso de medicamentos isentos de prescrição, devendo os usuários
ficarem atentos aos seus possíveis riscos.
DOI: 10.1590/S1518-8787.2016050006117
PMCID: PMC5157904
PMID: 27982373 [Indexed for MEDLINE]
Apr 5.
Author information:
(1)Public Health and Community Medicine Department, Faculty of Medicine, Mansoura
University, Mansoura, Egypt.
DOI: 10.1155/2017/9145193
PMCID: PMC5396441
PMID: 28479921 [Indexed for MEDLINE]
Ocan M(1), Obuku EA(2)(3), Bwanga F(4), Akena D(5), Richard S(6), Ogwal-Okeng
J(7), Obua C(8).
Author information:
(1)Department of Pharmacology & Therapeutics, College of Health Sciences,
Makerere University, P.O. Box 7072, Kampala, Uganda. mss_ocan@yahoo.co.uk.
(2)Africa Centre for Systematic Reviews and Knowledge Translation, College of
Health Sciences, Makerere University, P. O. Box 7072, Kampala, Uganda.
ekwaro@gmail.com.
(3)Faculty of Epidemiology and Population Health, London School of Hygiene and
Tropical Medicine, London, WC1E 7HT, UK. ekwaro@gmail.com.
(4)Department of Microbiology, College of Health Sciences, Makerere University,
P.O Box 7072, Kampala, Uganda. fxb18@case.edu.
(5)Department of Psychiatry, College of Health Sciences, Makerere University, P.O
Box 7072, Kampala, Uganda. akenadickens@yahoo.co.uk.
(6)Infectious Disease Institute, College of Health Sciences, Makerere University,
P.O Box 22418, Kampala, Uganda. ssenorichard@gmail.com.
(7)Department of Pharmacology & Therapeutics, College of Health Sciences,
Makerere University, P.O. Box 7072, Kampala, Uganda. jogwal.okeng@gmail.com.
(8)Department of Pharmacology & Therapeutics, College of Health Sciences,
Makerere University, P.O. Box 7072, Kampala, Uganda. cobua1953@gmail.com.
DOI: 10.1186/s12889-015-2109-3
PMCID: PMC4522083
PMID: 26231758 [Indexed for MEDLINE]
Author information:
(1)Department of Pharmacology, B. J. Medical College, Ahmedabad, Gujarat, India.
AIMS: This study aims to evaluate the knowledge and pattern of self-medication
for acne among undergraduate medical students at a tertiary care teaching
hospital.
MATERIALS AND METHODS: This cross-sectional study was conducted in II MBBS (Group
A), III MBBS Part I (Group B), and III MBBS Part II (Group C) students.
Prevalidated questionnaire about knowledge, attitude, and practice of
self-medication were administered to participants. Data were analyzed using
one-way analysis of variance and Chi-square test.
RESULTS: Out of 582 students who responded to questionnaire, 518 suffered from
acne. Self-medication practice was observed in 59.2% students. Significantly
higher number of female students practiced self-medication (P < 0.0001). Most
common source of information was seniors/friends/family members (34.2%). The
mildness of illness (42.3%) was the most common reason of self-medication. A
total mean score of knowledge was significantly higher in Group C as compared to
Group A (P < 0.001) and Group B (P < 0.05). Allopathic medication was preferred
by 69.8% students. Seventy-five percentage students read leaflet/package
insert/label instruction and expiry date of the medicines.
CONCLUSIONS: The participating students lack the knowledge about self-medication
for acne. Adequate knowledge and awareness about the appropriate use of
medication will reduce the practice of self-medication and improve rational
prescribing.
DOI: 10.4103/ijd.IJD_243_16
PMCID: PMC5363142
PMID: 28400638
Ulrich-Lai YM(1).
Author information:
(1)Department of Psychiatry and Behavioral Neuroscience, University of
Cincinnati, Cincinnati, OH 45140 USA.
For many individuals, stress promotes the consumption of sweet, high-sugar foods
relative to healthier alternatives. Daily life stressors stimulate the overeating
of highly-palatable foods through multiple mechanisms, including altered
glucocorticoid, relaxin-3, ghrelin and serotonin signaling in brain. In turn, a
history of consuming high-sugar foods attenuates the psychological (anxiety and
depressed mood) and physiological (HPA axis) effects of stress. Together the
metabolic and hedonic properties of sucrose contribute to its stress relief,
possibly via actions in both the periphery (e.g., glucocorticoid receptor
signaling in adipose tissue) and in the brain (e.g., plasticity in brain reward
regions). Emerging work continues to reveal the bidirectional mechanisms that
underlie the use of high-sugar foods as 'self-medication' for stress relief.
DOI: 10.1016/j.cobeha.2016.02.015
PMCID: PMC4787559
PMID: 26977424
Author information:
(1)Universidade Federal do Amazonas (UFAM), Instituto de Saúde e Biotecnologia.
Coari, Amazonas, Brasil.
(2)Universidade de São Paulo (USP), Escola de Enfermagem, Programa de
Pós-graduação em Enfermagem na Saúde do Adulto. São Paulo, São Paulo, Brasil.
DOI: 10.1590/1983-1447.2017.01.65111
PMID: 28538809 [Indexed for MEDLINE]
Author information:
(1)INSERM U 1219 - Pharmaco-épidémiologie et évaluation de l'impact des produits
de santé sur les populations, University de Bordeaux, Bordeaux, France.
(2)Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy,
Lebanese University, Beirut, Lebanon.
© 2017 The Authors. Pharmacology Research & Perspectives published by John Wiley
& Sons Ltd, British Pharmacological Society and American Society for Pharmacology
and Experimental Therapeutics.
DOI: 10.1002/prp2.323
PMCID: PMC5684864
PMID: 28805984
Rathish D(1), Wijerathne B(2), Bandara S(3), Piumanthi S(3), Senevirathna C(3),
Jayasumana C(3), Siribaddana S(4).
Author information:
(1)Department of Pharmacology, Faculty of Medicine and Allied Sciences, Rajarata
University of Sri Lanka, Saliyapura, Sri Lanka. rathishdeva@gmail.com.
(2)Department of Community Medicine, Faculty of Medicine and Allied Sciences,
Rajarata University of Sri Lanka, Saliyapura, Sri Lanka.
(3)Department of Pharmacology, Faculty of Medicine and Allied Sciences, Rajarata
University of Sri Lanka, Saliyapura, Sri Lanka.
(4)Department of Medicine, Faculty of Medicine and Allied Sciences, Rajarata
University of Sri Lanka, Saliyapura, Sri Lanka.
DOI: 10.1186/s13104-017-2688-4
PMCID: PMC5530969
PMID: 28750649 [Indexed for MEDLINE]
13. Int J Environ Res Public Health. 2017 Sep 29;14(10). pii: E1152. doi:
10.3390/ijerph14101152.
Author information:
(1)Department of Pharmacy Administration and Clinical Pharmacy, School of
Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
hassangillaniali@yahoo.com.
(2)Center for Drug Safety and Policy Research, Xi'an Jiaotong University, Xi'an
710061, China. hassangillaniali@yahoo.com.
(3)The Global Health Institute, Xi'an Jiaotong University, Xi'an 710061, China.
hassangillaniali@yahoo.com.
(4)Shaanxi Centre for Health Reform and Development Research, Xi'an 710061,
China. hassangillaniali@yahoo.com.
(5)Department of Pharmacy Administration and Clinical Pharmacy, School of
Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China. yfyx_8312@163.com.
(6)Center for Drug Safety and Policy Research, Xi'an Jiaotong University, Xi'an
710061, China. yfyx_8312@163.com.
(7)The Global Health Institute, Xi'an Jiaotong University, Xi'an 710061, China.
yfyx_8312@163.com.
(8)Shaanxi Centre for Health Reform and Development Research, Xi'an 710061,
China. yfyx_8312@163.com.
(9)Faculty of Pharmacy, Bahauddin Zakariya University Multan, Multan 66000,
Pakistan. dr.waqarwarraich@gmail.com.
(10)Faculty of Pharmacy, University of Lahore, Lahore 54000, Pakistan.
aliimran1232002@gmail.com.
(11)Department of Pharmacy Administration and Clinical Pharmacy, School of
Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
jiechang@mail.xjtu.edu.cn.
(12)Center for Drug Safety and Policy Research, Xi'an Jiaotong University, Xi'an
710061, China. jiechang@mail.xjtu.edu.cn.
(13)The Global Health Institute, Xi'an Jiaotong University, Xi'an 710061, China.
jiechang@mail.xjtu.edu.cn.
(14)Shaanxi Centre for Health Reform and Development Research, Xi'an 710061,
China. jiechang@mail.xjtu.edu.cn.
(15)Department of Pharmacy Administration and Clinical Pharmacy, School of
Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
yangcj@mail.xjtu.edu.cn.
(16)Center for Drug Safety and Policy Research, Xi'an Jiaotong University, Xi'an
710061, China. yangcj@mail.xjtu.edu.cn.
(17)The Global Health Institute, Xi'an Jiaotong University, Xi'an 710061, China.
yangcj@mail.xjtu.edu.cn.
(18)Shaanxi Centre for Health Reform and Development Research, Xi'an 710061,
China. yangcj@mail.xjtu.edu.cn.
(19)Department of Pharmacy Administration and Clinical Pharmacy, School of
Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
yufang@mail.xjtu.edu.cn.
(20)Center for Drug Safety and Policy Research, Xi'an Jiaotong University, Xi'an
710061, China. yufang@mail.xjtu.edu.cn.
(21)The Global Health Institute, Xi'an Jiaotong University, Xi'an 710061, China.
yufang@mail.xjtu.edu.cn.
(22)Shaanxi Centre for Health Reform and Development Research, Xi'an 710061,
China. yufang@mail.xjtu.edu.cn.
DOI: 10.3390/ijerph14101152
PMCID: PMC5664653
PMID: 28961191 [Indexed for MEDLINE]
Author information:
(1)Department of Applied Microbiology and Biotechnology, School of Biotechnology,
Yeungnam University, Gyeongsan, Gyeongbuk 38541, Republic of Korea.
(2)Probionic Institute, Jeonju-si, Jeollabuk-do, Republic of Korea.
The present study aims to explore the crisis of antibiotic resistance and
discover more about the current challenges related to self-medication. The
current challenges related to antibiotic resistance are unique and differ from
the challenges of the past since new bacterial pathogens are involved and
continue to evolve. Strains with resistance to multiple antibiotic classes have
emerged which the discovery of new antibiotics has failed to match. The
consequences of antibiotic resistance are grave with mortality and morbidity
continually on the rise. This paper also highlights the possible interventions
that can be effective at the micro or individual level in the prevention of
development of antibiotic resistance.
DOI: 10.1016/j.sjbs.2017.01.004
PMCID: PMC5415144
PMID: 28490950
15. Int J Infect Dis. 2017 Apr;57:3-12. doi: 10.1016/j.ijid.2017.01.014. Epub 2017
Jan 19.
Alhomoud F(1), Aljamea Z(2), Almahasnah R(2), Alkhalifah K(2), Basalelah L(2),
Alhomoud FK(3).
Author information:
(1)Department of Clinical and Pharmacy Practice, School of Clinical Pharmacy,
University of Dammam, Dammam 31952, Saudi Arabia. Electronic address:
f.k.alhomoud@gmail.com.
(2)Department of Clinical and Pharmacy Practice, School of Clinical Pharmacy,
University of Dammam, Dammam 31952, Saudi Arabia.
(3)Department of Clinical Pharmacy, College of Pharmacy, Umm Al-Qura University,
Mecca, Saudi Arabia.
OBJECTIVES: There has been no review on the prevalence, possible causes, and
clinical outcomes of self-medication with antibiotics (SMA) in the Middle East.
METHODS: Databases were searched (January 2000 through June 2016) for articles on
SMA among adults aged ≥18 years living in the Middle East. A hand search for
relevant citations and key journals was also performed.
RESULTS: Twenty-two studies were found. The prevalence of SMA ranged from 19% to
82%. Age, sex, and educational and income levels were the main determinants of
SMA. Socio-cultural, economic, and regulatory factors were the most commonly
cited reasons for SMA. Penicillins were the antibiotics most commonly used; the
antibiotics were obtained mainly via stored leftover drugs, pharmacies without
prescriptions, and friends/relatives. SMA was mainly for upper respiratory tract
problems. The primary sources of drug information included relatives/friends and
previous successful experience. Inappropriate drug use such as wrong indication,
short and long duration of treatment, sharing of antibiotics, and storing
antibiotics at home for use at a later time were reported. Negative and positive
outcomes of SMA were identified.
CONCLUSIONS: It is important to understand the links between different factors
promoting SMA and to assess the changing trends in order to derive strategies
aimed at reducing drug-related health risks.
Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.ijid.2017.01.014
PMID: 28111172 [Indexed for MEDLINE]
Gelayee DA(1).
Author information:
(1)Department of Pharmacology, College of Medicine and Health Sciences,
University of Gondar, Gondar, Ethiopia.
DOI: 10.1155/2017/8680714
PMCID: PMC5278208
PMID: 28191360
Alghadeer S(1), Aljuaydi K(2), Babelghaith S(1), Alhammad A(1), Alarifi MN(1).
Author information:
(1)Department of Clinical Pharmacy, College of Pharmacy, King Saud University,
Riyadh, Saudi Arabia.
(2)College of Medicine, King Saud University, Riyadh, Saudi Arabia.
DOI: 10.1016/j.jsps.2018.02.018
PMCID: PMC6035317
PMID: 29991916
Author information:
(1)Al-Dora Health-Care Centre for Family Medicine, Al-Karkh Health Directorate,
Ministry of Health, Baghdad, Iraq.
(2)Noncommunicable Diseases Control Department, Public Health Directorate,
Ministry of Health, Baghdad, Iraq.
(3)College of Medicine, Al-Mustansiriyah University, Baghdad, Iraq.
The objective of this study is to find out the prevalence and determinants of
self-medication among college students in Baghdad, Iraq. A cross-sectional survey
was conducted in Al-Mustansiriyah and Al-Nahrain universities, Baghdad, from
January to April 2015. A multistage random sampling technique was adopted to
collect data from 1435 college students using a questionnaire form. The mean age
of the joining students was 19.8 years. Females form 53% of the sample.
Self-medications use was prevalent among 92.4% of students. Antipyretics and
antibiotics were the most used medicines. Self-medication was higher among urban
residents (OR= 7.99, P < 0.001). Students living with their families practiced
self-medication more than others (OR= 2.501, P = 0.037). Students at
health-related colleges showed greater resilience to self-medication (OR=0.455, P
= 0.001). Despite free access to healthcare institutions, nine out of ten college
students from Baghdad universities have practiced self-medication. Education of
students about the safe use of medications and supervision of pharmacies are
effective ways to control this malpractice.
Publisher: دراسة مستعررضة:معدل انتشار التطبيب الذاتي بين طلب الجامعة في بغداد
الهدف من هذه. رياض خضير لفتة، هشام جاسم عبد البدري،رؤى جعفر العامري.من العراق
الدراسة هو معرفة معددل انتشار التطبيب الذاتي ومحددداته بن طاب الجامعات في بغداد،
في الفرة من، في بغداد، أجريت دراسة مقطعية في جامعتريي المستنصرية والنهرين.العراق
واعتمد الباحثون أسلوب أخذ العينات.2015 نيسان/كانون الثاني إلى أبريل/يناير
طالبا ا من طاب الجامعات باستخدام1435 العشوائية المتعددة المراحل لجمع البيانات من
عاما ا19.8 وكان متوسط العمر لدى الطاب الذين انضموا إلى الدراسة.نموذج الستبيان.
من٪92.4 وكان استخدام الدوية الذاتية منترا ا بن. من العينة٪ 53 وشكل الناث
وكانت الدوية الخافضة للحرارة والمضادات الحيوية هي الدوية الكثر.الطاب
وكان معددل انتشار التطبيب الذاتي أعى بن سكان الحر.( استخداما اOR=7.99, P <
0.001). وكان الطاب الذين يعيشون مع أسرهم يمارسون التطبيب الذاتي أكثر من غيرهم
(OR=2.501, P = 0.037). وأظهر الطاب في الكليات ذات الصلة بالصحة مرونة أكر للعاج
( الذاتيOR=0.455, P = 0.001). وعى الرغم من أن الحصول عى الرعاية الصحية من
فإن تسعة من كل عشرة طاب من جامعات بغداد قد مارسوا التطبيب،المؤسسات مجانية
ويعتر تعليم الطاب للستخدام المن للدوية والشراف عى الصيدليات من.الذاتي
الوسائل الفدعالة لمكافحة هذه الممارسات الخاطئة.Publisher: Prévalence de
l’automédication parmi les étudiants à l’Université de Bagdad : étude
transversale iraquienne.La présente étude a pour objectif d’estimer la prévalence
de l’automédication et d’en identifier les déterminants parmi les étudiants à
l’Université de Bagdad (Iraq). Une étude transversale a été menée dans les
universités d’Al- Mustansiriyah et d’Al-Nahrain à Bagdad, entre janvier et avril
2015. Une technique d’échantillonnage aléatoire à plusieurs degrés a été adoptée
afin de collecter les données auprès de 1435 étudiants à l’aide d’une
questionnaire. L’âge moyen des étudiants ayant participé à l’étude était de 19,8
ans, et 53 % étaient des femmes dans l'échantillon. L’automédication était
prévalente pour 92,4 % des étudiants. Les médicaments les plus utilisés étaient
les antipyrétiques et les antibiotiques. L’automédication était plus élevée parmi
les citadins (OR = 7,99, p < 0,001). Les étudiants vivant encore chez leurs
parents pratiquaient davantage l’automédication que les autres (OR = 2,501, p =
0,037). Les étudiants qui suivaient des études dans le domaine de la santé
avaient moins tendance à recourir à l’automédication (OR = 0,455, p = 0,001).
Malgré un accès libre aux établissements de soins de santé, neuf étudiants sur
dix des universités de Bagdad avaient déjà pratiqué l’automédication. Éduquer les
étudiants à une consommation sans risque des médicaments et mettre en place une
surveillance des pharmacies constituent des moyens efficaces pour remédier à
cette mauvaise pratique.
Author information:
(1)Department of Experimental Medicine, Second University of Naples, Naples,
Italy.
The aims of this cross-sectional survey were to document the prevalence, the
determinants, and the reasons of oral medication use without the prescription of
a physician among a random sample of 672 parents of students attending randomly
selected public schools in Italy. A total of 69.2% practiced self-medication at
least once. The odds of having performed a self-medication were higher in
females, in younger population, and in those who have had a health problem in the
preceding year and were lower in respondents with a middle or lower school level
of education. Among those reporting experience of self-medication, 53.4% have
practiced at least once in the last year and this was more likely for those who
have had a health problem. Nonsteroidal anti-inflammatory drugs were more
frequently used without a prescription in the last year. Two-thirds
inappropriately self-medicated in the last year at least once. Of those who did
not report a self-medication, 13.1% were willing to practice it. Females were
more willing and those with a secondary school level of education less willing to
practice self-medication. The frequency of oral self-medication was quite high
and in most cases inappropriate with a potential impact on the health status and
educative programs are needed.
DOI: 10.1155/2015/580650
PMCID: PMC4320888
PMID: 25688359 [Indexed for MEDLINE]
Author information:
(1)Kermanshah University of Medical Sciences. akhatony@kums.ac.ir.
DOI: 10.5539/gjhs.v7n2p360
PMCID: PMC4796481
PMID: 25716414 [Indexed for MEDLINE]
21. Rural Remote Health. 2017 Apr-Jun;17(2):3893. doi: 10.22605/RRH3893. Epub 2017
Apr 7.
Author information:
(1)Taborska 8, 2000 Maribor, Slovenia. zalika.klemenc.ketis@gmail.com.
(2)Poljanski nasip 58, 1000 Ljubljana, Slovenia. daca.nbanja@gmail.com.
DOI: 10.22605/RRH3893
PMID: 28411404 [Indexed for MEDLINE]
Author information:
(1)Pharmacoepidemiology and Social Pharmacy Unit, Department of Pharmacy, College
of Health Sciences, Wollega University, P.O.Box 395, Nekemte, Ethiopia.
edaosd6@gmail.com.
(2)Boru Meda Hospital, Amhara National Regional State, Dessie, Ethiopia.
(3)Clinical Pharmacy Unit, Department of Pharmacy, College Health of Sciences,
Wollega University, Nekemte, Ethiopia.
(4)Pharmaceutics Unit, Department of Pharmacy, College Health of Sciences,
Wollega University, Nekemte, Ethiopia.
DOI: 10.1186/s13104-017-2865-5
PMCID: PMC5663131
PMID: 29084581 [Indexed for MEDLINE]
23. Pan Afr Med J. 2017 Sep 4;28:4. doi: 10.11604/pamj.2017.28.4.12589. eCollection
2017.
Author information:
(1)Université Notre-Dame d'Haïti, Faculté de Médecine et des Sciences de la Santé
6, Rue Sapotille, Port-au-Prince, Haiti.
In Haiti, where all drugs are available over the counter, self-medication with
antibiotics appears as a common practice. Inappropriate use of beta-lactams and
macrolides is likely to contribute to the development of antimicrobial
resistance. This study aimed to (i) assess the extent of self-medication with
antibiotics, (ii) explore the contributing factors (age, gender and educational
background) and (iii) identify specific antibiotic drug classes used among
patients attending the outpatient clinic of the State University Hospital of
Port-au-Prince. A cross-sectional survey among 200 outpatients of the State
University Hospital of Port-au-Prince was conducted in December 2014.
Face-to-face interviews were conducted using a standardized questionnaire.
Parents of pediatric patients were allowed to answer to questions on their
behalf. Among the study sample, 45.5% practiced self-medication with antibiotics.
It was less prevalent among patients with the highest education level (23.1%; OR:
0.89 (0.5-1.75), p = 0.001). Mild symptoms (28.6%) and vaginal itching (44.4%)
were the main reasons for self-medication with antibiotics. Self-medication using
amoxicillin was reported by 67.0%. Self-medication with antibiotics is a common
practice among Haitian patients and is more common among the less educated.
Amoxicillin for urinary tract infections is the most commonly used medication. It
is crucial to raise awareness on the dangers of the practice in the population
and inforce the current law regarding the use of over the counter antibiotics.
DOI: 10.11604/pamj.2017.28.4.12589
PMCID: PMC5681018
PMID: 29138650 [Indexed for MEDLINE]
Analgesics Self-Medication and its Association with Sleep Quality among Medical
Undergraduates.
Author information:
(1)Assistant Professor, Department of Pharmacology, Narayan Medical College and
Hospital , Sasaram, Bihar, India .
(2)Assistant Professor, Department of Physiology, Narayan Medical College and
Hospital , Sasaram, Bihar, India .
(3)Assistant Professor, Department of Community Medicine, Narayan Medical College
and Hospital , Sasaram, Bihar, India .
Niknam R(1), Mousavi S(2), Safarpour A(3), Mahmoudi L(4), Mahmoudi P(5).
Author information:
(1)Gastroenterohepatology Research Center, Shiraz, Fasa, Iran; Department of
Internal Medicine, Fasa University of Medical Sciences, Fasa, Iran.
(2)Department of Clinical Pharmacy and Pharmacy Practice, Isfahan University of
Medical Sciences, Isfahan, Iran.
(3)Gastroenterohepatology Research Center, Shiraz, Fasa, Iran.
(4)Department of Clinical Pharmacy, Shiraz University of Medical Sciences,
Shiraz, Iran.
(5)Pharmaceutical Science Research Center, Shiraz University of Medical Sciences,
Shiraz, Iran.
DOI: 10.4103/2279-042X.179576
PMCID: PMC4843581
PMID: 27162806
Author information:
(1)Deparment of Obstetrics and Gynecology, Babu Jagjivan Ram Memorial Hospital,
Delhi, India.
(2)Sanjibani-321, Sunderban, Phase 2, Iqra Colony, Mango, Jamshedpur, Jharkhand
832110 India.
(3)Babu Jagjivan Ram Memorial Hospital, Delhi, India.
Comment on
J Obstet Gynaecol India. 2017 Feb;67(1):37-41.
DOI: 10.1007/s13224-017-1005-4
PMCID: PMC5561750
PMID: 28867892
Babatunde OA(1), Fadare JO(2), Ojo OJ(1), Durowade KA(3), Atoyebi OA(4), Ajayi
PO(1), Olaniyan T(1).
Author information:
(1)Department of Community Medicine, Federal Medical Center, Ido-Ekiti, Nigeria.
(2)Department of Pharmacology, College of Medicine, Ekiti State University,
Ado-Ekiti, Nigeria.
(3)Department of Community Medicine, Unilorin Teaching Hospital, Ilorin, Nigeria.
(4)Department of Community Medicine, Federal Medical Center, P.M.B 201,
Ido-Ekiti, Nigeria.
DOI: 10.11604/pamj.2016.24.312.8146
PMCID: PMC5267862
PMID: 28154667 [Indexed for MEDLINE]
Topor G(#)(1), Grosu IA(#)(1), Ghiciuc CM(1), Strat AL(1)(2), Lupuşoru CE(1).
Author information:
(1)Department of Pharmacology-Morphofunctional Sciences II, University of
Medicine and Pharmacy Grigore T. Popa, Iasi, Romania.
(2)Laboratory of Microbiology, Hospital of Infectious Diseases Saint Parascheva,
Iasi, Romania.
(#)Contributed equally
DOI: 10.7717/peerj.3803
PMCID: PMC5600173
PMID: 28924507
Pons EDS(1), Knauth DR(1), Vigo Á(1); PNAUM Research Group, Mengue SS(1).
Author information:
(1)Graduate Program in Epidemiology, Federal University of Rio Grande do Sul,
Porto Alegre, Rio Grande do Sul, Brazil.
DOI: 10.1371/journal.pone.0189098
PMCID: PMC5722370
PMID: 29220378 [Indexed for MEDLINE]
Self-medication practices and rational drug use habits among university students:
a cross-sectional study from Kahramanmaraş, Turkey.
Okyay RA(1), Erdoğan A(1).
Author information:
(1)Faculty of Medicine, Department of Public Health, Kahramanmaraş Sütçü İmam
University, Kahramanmaraş, Turkey.
DOI: 10.7717/peerj.3990
PMCID: PMC5671114
PMID: 29109916
Bilal M(1), Haseeb A(2), Khan MH(3), Arshad MH(3), Ladak AA(4), Niazi SK(4),
Musharraf MD(5), Manji AA(5).
Author information:
(1)Faculty, Department of Medicine, Dow Medical College. Dow University of Health
Sciences , Karachi, Pakistan .
(2)Faculty, Department of Medicine, Dow Medical College, Dow University of Health
Sciences , Karachi, Pakistan .
(3)Faculty, Department of Medicine, Medical College, Aga Khan University Hospital
, Karachi, Pakistan .
(4)Pre-Medical Student, Department of Biological Sciences, The Lyceum , Karachi,
Pakistan .
(5)Pre-Medical Student, Department of Biological Sciences, Karachi Grammar School
, Karachi, Pakistan .
DOI: 10.7860/JCDR/2016/18294.7730
PMCID: PMC4948439
PMID: 27437263
32. Pharmacy (Basel). 2017 Sep 4;5(3). pii: E51. doi: 10.3390/pharmacy5030051.
Author information:
(1)College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University
(University of Dammam), Dammam 31441, Saudi Arabia. ph.fatimahali582@gmail.com.
(2)Department of Pharmacy Practice, College of Clinical Pharmacy, Imam
Abdulrahman Bin Faisal University (University of Dammam), Dammam 31441, Saudi
Arabia. aaghulam@uod.edu.sa.
(3)Natural Products and Alternative Medicines, College of Clinical Pharmacy, Imam
Abdulrahman Bin Faisal University (University of Dammam), Dammam 31441, Saudi
Arabia. rizvistar_36@yahoo.com.
(4)Department of Pharmaceutics, College of Clinical Pharmacy, Imam Abdulrahman
Bin Faisal University (University of Dammam), Dammam 31441, Saudi Arabia.
niyazpharma@gmail.com.
DOI: 10.3390/pharmacy5030051
PMCID: PMC5622363
PMID: 28970463
33. Int J Environ Res Public Health. 2018 Jan 4;15(1). pii: E68. doi:
10.3390/ijerph15010068.
Lei X(1), Jiang H(2)(3), Liu C(4), Ferrier A(5), Mugavin J(6).
Author information:
(1)School of Management, Hubei University of Chinese Medicine, Wuhan 430065,
China. xslei@hbtcm.edu.cn.
(2)Centre for Alcohol Policy Research, School of Psychology and Public Health, La
Trobe University, Melbourne, VIC 3086, Australia. Jason.Jiang@latrobe.edu.au.
(3)Melbourne School of Population and Global Health, University of Melbourne,
Melbourne, VIC 3010, Australia. Jason.Jiang@latrobe.edu.au.
(4)Department of Public Health, School of Psychology and Public Health, La Trobe
University, Melbourne, VIC 3086, Australia. C.Liu@latrobe.edu.au.
(5)Department of Public Health, School of Psychology and Public Health, La Trobe
University, Melbourne, VIC 3086, Australia. adamm.ferrier@latrobe.edu.au.
(6)Centre for Alcohol Policy Research, School of Psychology and Public Health, La
Trobe University, Melbourne, VIC 3086, Australia. J.Mugavin@latrobe.edu.au.
BACKGROUND: This study aims to examine the prevalence and predictors associated
with self-medication, and related consequences in Wuhan, China.
METHODS: Two-hundred-sixty residents were interviewed from randomly selected four
districts of Wuhan, China. A modified version of Anderson's health behavioral
model was used in the survey to collect information of self-medication behavior.
Multivariable logistic regression analyses were used to measure correlates of the
prevalence of self-medication.
RESULTS: Nearly half of the respondents would select self-medication, and 39.1%
would see a doctor if they felt sick. The most common self-medicated illnesses
were cold and cough, cardiovascular disease and gastrointestinal disease. The
main reasons for self-medication were that the illness was not severe (enough) to
see the doctor (45%); the patient did not think that the trouble of seeing a
doctor was worth the effort (23%); the patient had no time to see the doctor
(12%), and the patient did not want to pay high medical costs (15%). Logistic
regression results suggested that respondents tended to select self-medication if
the illness was minor or short-term (less than seven days).
CONCLUSIONS: Our findings suggest that more strict regulation on over-the-counter
medicines may be required to reduce health risks related to self-medication.
Targeted health education on the risks of self-medication should be considered.
DOI: 10.3390/ijerph15010068
PMCID: PMC5800167
PMID: 29300318 [Indexed for MEDLINE]
Morrogh-Bernard HC(1)(2), Foitová I(3), Yeen Z(4), Wilkin P(5), de Martin R(6),
Rárová L(7), Doležal K(7), Nurcahyo W(8), Olšanský M(9).
Author information:
(1)The Orang-utan Tropical Peatland Project (OuTrop), Palangkaraya, Central
Kalimantan, Indonesia.
(2)Centre for Ecology & Conservation, College of Life and Environmental Sciences
University of Exeter, Penryn Campus, Penryn, Cornwall, TR10 9FE, United Kingdom.
(3)Department of Botany and Zoology, Masaryk University, Kotlářská 2, 611 37,
Brno, Czech Republic. foitova@sci.muni.cz.
(4)The Centre for International Cooperation in Sustainable Management of Tropical
Peatlands (CIMTROP), University of Palangka Raya, Central Kalimantan, Indonesia.
(5)Royal Botanic Gardens, Kew, Richmond, Surrey, UK.
(6)Department of Vascular Biology and Thrombosis Research, Medical University of
Vienna, A-1090, Vienna, Austria.
(7)Department of Chemical Biology and Genetics & Laboratory of Growth Regulators,
Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty
of Science, Palacký University and Institute of Experimental Botany, Academy of
Sciences of Czech Republic, 78371, Olomouc-Holice, Czech Republic.
(8)Department of Parasitology, Faculty of Veterinary Medicine, Gadjah Mada
University, Yogyakarta, Indonesia.
(9)Foundation UMI-Saving of Pongidae, Brno, Czech Republic.
DOI: 10.1038/s41598-017-16621-w
PMCID: PMC5709421
PMID: 29192145 [Indexed for MEDLINE]
Domingues PH, Galvão TF, Andrade KR, Sá PT, Silva MT, Pereira MG.
DOI: 10.1590/s0034-8910.2015049005709
PMCID: PMC4544343
PMID: 26083944 [Indexed for MEDLINE]
Author information:
(1)Department of Pharmacology, MKCG Medical College, Berhampur, Odisha, India.
(2)Department of Community Medicine, MKCG Medical College, Berhampur, India.
(3)Department of Pharmacology, S.C.B. Medical College, Cuttack, Odisha, India.
OBJECTIVES: The objective of this study is to identify and compare the nature of
the drug-related problems (DRPs) associated with self-medication and
non-self-medication (drug use guided by a prescription).
MATERIALS AND METHODS: The cross-sectional, observational study was conducted on
1100 adult participants at a convenience sample of six retail private pharmacy
counters. The data collection form was based on the Pharmaceutical Care Network
Europe version 6.2 classification for DRPs. Descriptive statistics was used to
represent the prevalence of DRPs. Chi-square test was used to find out the
association between the type of medication and DRPs. Odds ratio (OR) with
confidence interval (CI) was computed to find the factors determining the
occurrence of DRPs. P < 0.05 was considered to be statistically significant. Data
were analyzed using SPSS version 16.0.
RESULTS: The prevalence of self-medication was 18.72%. The prevalence of DRPs was
17.36%. In the self-medication group, the prevalence of DRPs was high (40.78%) as
compared to the non-self-medication group (11.97%). DRP related to inappropriate
drug dosing was observed in 44.83% and 40.45% subjects in self-medication and
non-self-medication group, respectively (P < 0.001). The subjects in the
self-medication group were about 5 times likely to have a DRP (OR: 5.06, CI:
3.59-7.14, P < 0.001).
CONCLUSIONS: Self-medication is associated with a higher risk of various DRPs.
Since retail pharmacy outlet is often the first point of contact between the
patient and the health care system in a developing country, interventions like
drug information activities at the retail pharmacy is likely to bring down the
DRPs associated with self-medication.
DOI: 10.4103/0253-7613.190728
PMCID: PMC5051244
PMID: 27721536 [Indexed for MEDLINE]
Author information:
(1)Department of Business Administration (Statistics), Stamford University
Bangladesh, Dhaka-1217, Bangladesh. nazninalam@gmail.com.
(2)Marketing Division, Renata Limited, Dhaka-1216, Bangladesh.
nsaffoon@gmail.com.
(3)Department of Pharmacy, Stamford University Bangladesh, Dhaka-1217,
Bangladesh. kp_ruddin@yahoo.com.
DOI: 10.1186/s13104-015-1737-0
PMCID: PMC4675016
PMID: 26652176 [Indexed for MEDLINE]
Fernando ADA(1), Bandara LMH(2), Bandara HMST(2), Pilapitiya S(3), de Silva A(2).
Author information:
(1)Department of Physiology, Faculty of Medicine, University of Colombo, No 25,
Kynsey Road, Colombo 8, Sri Lanka. dinithianush@gmail.com.
(2)Department of Physiology, Faculty of Medicine, University of Colombo, No 25,
Kynsey Road, Colombo 8, Sri Lanka.
(3)Sri Lanka Anti-doping Agency, Institute of Sports Medicine, Independence
Avenue, Colombo 7, Sri Lanka.
DOI: 10.1186/s13104-017-2579-8
PMCID: PMC5501524
PMID: 28683782 [Indexed for MEDLINE]
Jamshed SQ(1), Wong PS(2), Yi HC(2), Yun GS(2), Khan MU(2), Ahmad A(3).
Author information:
(1)Department of Pharmacy Practice, Kulliyyah of Pharmacy, International Islamic
University Malaysia, Kuantan Campus, Pahang 25200, Malaysia.
(2)Department of Pharmacy Practice, School of Pharmacy, International Medical
University, Cheras-56000, Kuala Lumpur, Malaysia.
(3)Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, UCSI
University, Cheras-56000, Kuala Lumpur, Malaysia.
DOI: 10.4103/0975-7406.172662
PMCID: PMC4929961
PMID: 27413350
Author information:
(1)Departamento de Saúde Coletiva, Faculdade de Ciências Médicas, Universidade
Estadual de Campinas - Campinas (SP), Brasil.
(2)Centro de Ciências da Vida, Faculdade de Ciências Farmacêuticas, Pontifícia
Universidade Católica - Campinas (SP), Brasil.
DOI: 10.1590/1980-5497201600030010
PMID: 27849273 [Indexed for MEDLINE]
Author information:
(1)Department of Pharmacy Administration and Clinical Pharmacy, School of
Pharmacy, Xi'anJiaotong University, Xi'an, China.
(2)Center for Drug Safety and Policy Research, Xi'an Jiaotong University, Xi'an,
China.
(3)The Global Health Institute, Xi'an Jiaotong University, Xi'an, China.
(4)Shaanxi Center for Health Reform and Development Research, Xi'an, China.
(5)Faculty of Pharmacy and Alternative Medicine, The Islamia University of
Bahawalpur, Bahawalpur, Punjab, Pakistan.
(6)Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
(7)Institute of Pharmaceutical Sciences, University of Veterinary & Animal
Sciences, Lahore, Pakistan.
DOI: 10.1371/journal.pone.0194240
PMCID: PMC5863987
PMID: 29566014 [Indexed for MEDLINE]
Author information:
(1)Departamento de Farmacia, División de Ciencias Naturales y Exactas,
Universidad de Guanajuato, Guanajuato, Mexico.
(2)Departamento de Ciencias Médicas, División de Ciencias de la Salud,
Universidad de Guanajuato, León, Guanajuato, Mexico.
(3)Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro
Social, Metepec, Puebla, Mexico.
(4)Unidad Académica Multidisciplinaria de la Zona Huasteca, Universidad Autónoma
de San Luis Potosí, Ciudad Valles, San Luis Potosí, Mexico.
(5)Hospital General, Instituto de Seguridad y Servicios Sociales de los
Trabajadores del Estado, San Luis Potosí, Mexico.
(6)Departamento de Química, División de Ciencias Naturales y Exactas, Universidad
de Guanajuato, Guanajuato, Mexico.
Self-medication during pregnancy represents a serious threat for mother and child
health. The objective of this study was to evaluate the prevalence and the
factors associated with self-medication among Mexican women living in the central
region of Mexico. This is a descriptive interview-study of 1798 pregnant women or
women who were pregnant no more than 3 years ago, when the interview was carried
out. Data analysis was carried out with chi-square analysis and odds ratio. The
prevalence of self-medication (allopathic drugs, medicinal plants, and other
products, including vitamins, food supplements, among others) was 21.9%. The
factors associated (p < 0.05) with self-medication were: higher education
(college and postgraduate), smoking, and consumption of alcohol. Smoking was the
strongest factor (OR: 2.536; 1.46-4.42) associated to self-medication during
pregnancy, followed by consumption of alcohol (OR: 2.06; 1.38-3.08), and higher
education (OR: 1.607; 1.18-2.19). Medicinal plant consumption was associated with
nausea, constipation, migraine, and cold (p < 0.05), whereas he self-medication
of allopathy was associated with gastritis and migraine (p < 0.05).
Self-medication was influenced mainly by a relative or friend, who recommended
the use of herbal medicine/allopathic medication. Two of the most common
medicinal plants (arnica and ruda) here informed are reported to induce abortion
or toxicity during pregnancy. The findings showed that self-medication (medicinal
plants and allopathic medication) is a common practice among pregnant women from
central Mexico. Adequate counselling of pregnant women by healthcare
professionals about the potential risks of self-medication with herbal medicine
and allopathic drugs during pregnancy is strongly warranted.
DOI: 10.1016/j.jsps.2018.03.008
PMCID: PMC6128711
PMID: 30202232
Kanwal ZG(1), Fatima N(1), Azhar S(1), Chohan O(2), Jabeen M(3), Yameen MA(1).
Author information:
(1)Department of Pharmacy, COMSATS.
(2)Department of Mathematics, COMSATS.
(3)Faculty of Contemporary Institute of Information Technology, Abbottabad.
PMID: 30317266
DOI: 10.1590/S0102-67202014000400016
PMCID: PMC4743226
PMID: 25626943 [Indexed for MEDLINE]
Author information:
(1)Wollo Tertiary Care and Teaching Hospital, Wollo, Ethiopia.
(2)Department of Clinical Pharmacy, School of Pharmacy, College of Health and
Medical Sciences, Haramaya University, Harar, Ethiopia.
DOI: 10.1155/2018/2757108
PMCID: PMC6083478
PMID: 30147983
Zhu X(1), Pan H(2), Yang Z(3), Cui B(4), Zhang D(5), Ba-Thein W(6).
Author information:
(1)Medical Simulation Center, School of Clinical Medicine, Jiangsu University,
Zhenjiang, Jiangsu, 212013, PR China. Electronic address: 372113325@qq.com.
(2)Shantou-Oxford Clinical Research Unit, Shantou University Medical College,
Shantou, Guangdong, 515041, PR China. Electronic address: michaelpan@stu.edu.cn.
(3)Shantou-Oxford Clinical Research Unit, Shantou University Medical College,
Shantou, Guangdong, 515041, PR China. Electronic address: fsyz30147@163.com.
(4)Pediatric Department, The First Affiliated Hospital of Shantou University
Medical College, Shantou, Guangdong, 515041, PR China. Electronic address:
binglincui@stu.edu.cn.
(5)Research Center of Translational Medicine, The Second Affiliated Hospital of
Shantou University Medical College, Shantou, Guangdong, 515041, PR China.
Electronic address: danguizhang@stu.edu.cn.
(6)Shantou-Oxford Clinical Research Unit, Shantou University Medical College,
Shantou, Guangdong, 515041, PR China; Department of Microbiology and Immunology,
Shantou University Medical College, Shantou, Guangdong, 515041, PR China.
Electronic address: wbathein@stu.edu.cn.
Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.puhe.2015.04.005
PMID: 26008209 [Indexed for MEDLINE]
Author information:
(1)Maharajgunj Medical Campus, Tribhuvan University Institute of Medicine.
DOI: 10.7759/cureus.2428
PMCID: PMC5988199
PMID: 29876150
Ahmadi SM(1), Jamshidi K(2), Sadeghi K(3), Abdi A(4), Vahid MP(5).
Author information:
(1)PhD Student of Clinical Psychology, Department of Psychiatry, Kermanshah
University of Medical Sciences , Kermanshah, Iran .
(2)Student of Public Health, The Student Research Committee, Kermanshah
University of Medical Sciences , Kermanshah, Iran .
(3)Assistance Professor of Psychology, Department of Psychiatry, Kermanshah
University of medical sciences , Kermanshah, Iran .
(4)PhD Student of Nursing, Nursing and Midwifery School, Shahid Beheshti
University of Medical Sciences , Tehran, Iran .
(5)Student, Department of Clinical Psychology, Kermanshah University of Medical
Sciences , Kermanshah, Iran .
DOI: 10.7860/JCDR/2016/18018.7847
PMCID: PMC4948418
PMID: 27437242
Azami-Aghdash S(1), Mohseni M(2), Etemadi M(3), Royani S(4), Moosavi A(5),
Nakhaee M(6).
Author information:
(1)Road Traffic Injury Research Center, Tabriz University of Medical Sciences,
Tabriz, Iran.
(2)Health Management and Economics Research Center, Isfahan University of Medical
Sciences, Isfahan, Iran; School of Public Health, Tehran University of Medical
Sciences, Tehran, Iran.
(3)Health Management and Economics Research Center, Iran University of Medical
Sciences, Tehran, Iran.
(4)School of Health Management and Information Sciences, Iran University of
Medical Sciences, Tehran, Iran.
(5)Dept. of Health and Community Medicine, Dezful University of Medical Sciences,
Dezful, Iran.
(6)Health Services Management Research Center, Institute for Futures Studies in
Health, Kerman University of Medical Sciences, Kerman, Iran.
PMCID: PMC4724731
PMID: 26811809
50. Risk Manag Healthc Policy. 2018 Sep 12;11:169-176. doi: 10.2147/RMHP.S170181.
eCollection 2018.
Author information:
(1)Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of
Science and Technology, Irbid, Jordan, oyalshogran@just.edu.jo.
(2)Department of Medical Laboratory Sciences, Faculty of Applied Medical
Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Comment in
Risk Manag Healthc Policy. 2019 Jan 15;12:1-3.
DOI: 10.2147/RMHP.S170181
PMCID: PMC6143637
PMID: 30254501
Domingues PHF(1), Galvão TF(2), Andrade KRC(1), Araújo PC(3), Silva MT(4),
Pereira MG(1).
Author information:
(1)Universidade de Brasília, Faculdade de Medicina, Brasília-DF, Brasil.
(2)Universidade Estadual de Campinas, Faculdade de Ciências Farmacêuticas,
Campinas-SP, Brasil.
(3)Universidade Federal de Uberlândia, Faculdade de Odontologia, Uberlândia-MG,
Brasil.
(4)Universidade de Sorocaba, Programa de Pós-Graduação em Ciências Farmacêuticas,
Sorocaba-SP, Brasil.
DOI: 10.5123/S1679-49742017000200009
PMID: 28492773 [Indexed for MEDLINE]
Dawood OT(1), Hassali MA(2), Saleem F(3), Ibrahim IR(4), Abdulameer AH(5), Jasim
HH(6).
Author information:
(1)Department of Medical Services, Ministry of Science and Technology. Baghdad (
Iraq ). othd2000@yahoo.com.
(2)Discipline of Social and Administrative Pharmacy, School of Pharmaceutical
Sciences, Universiti Sains Malaysia. Penang ( Malaysia ). azmihassali@gmail.com.
(3)Faculty of Pharmacy and Health Sciences, University of Baluchistan, Quetta (
Pakistan ). fahaduob@gmail.com.
(4)Discipline of Social and Administrative Pharmacy, School of Pharmaceutical
Sciences, Universiti Sains Malaysia. Penang ( Malaysia ). phm.enas@yahoo.com.
(5)Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti
Sains Malaysia. Penang ( Malaysia ). ahmed2010y66@yahoo.com.
(6)Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti
Sains Malaysia. Penang ( Malaysia ). hananpharm83@yahoo.com.
DOI: 10.18549/PharmPract.2017.03.991
PMCID: PMC5597809
PMID: 28943981
53. Trop Med Health. 2018 May 1;46:10. doi: 10.1186/s41182-018-0091-z. eCollection
2018.
Author information:
(1)Ethiopian Food, Medicine and Healthcare Administration and Control Authority,
Addis Ababa, Ethiopia.
(2)GAMBY College of Medical Sciences, Addis Ababa, Ethiopia.
Background: Self-medication which is the act of obtaining and using one or more
medicines without medical supervision is a common practice among pregnant women.
Unless proper caution is taken, it may result in maternal and fetal adverse
outcomes. In Ethiopia, information on self-medication practice during pregnancy
is scanty. Hence, this study aimed to assess self-medication practice and
associated factors among pregnant women in government health centers in Addis
Ababa.
Methods: An institution-based mixed study design using a sequential explanatory
approach was employed among 617 pregnant women and nine key informants in Addis
Ababa from May 8, 2017, to June 30, 2017. Multi-stage sampling technique was used
to select study participants, and purposive sampling technique was used to select
the key informants. The quantitative data were collected using a structured
interview questionnaire and analyzed using Statistical Product and Service
Solutions (SPSS) version 23.0 whereas semi-structured questionnaire was used for
in-depth interviews. Binary logistic regression was used for quantitative data
analysis, and thematic analysis method was used for qualitative data.
Results: The prevalence of self-medication practice was 26.6%. Previous
medication use (Adjusted odds ratio (AOR) = 4.20, 95% CI 2.70-6.53), gestational
period (AOR = 0.63, 95% CI 0.41-0.98), education on self-medication (AOR = 0.36,
95% CI 0.21-0.62), previous pregnancy and delivery related problems (AOR = 1.71,
95% CI 1.06-2.76), and knowledge about risk of self-medication (AOR = 0.64, 95%
CI 0.42-0.97) were significantly associated with self-medication practice. Lack
of attention and priority of program designers, absence of strategies and
guidelines; weak screening mechanisms, and regulatory enforcement were cited by
the key informants as contributing factors for self-medication practices.
Conclusions: Considerable proportion of pregnant women practiced self-medication,
including medicines categorized to have high risks. Gestational period, previous
medication use, education on self-medication, previous pregnancy- and
delivery-related problems, and knowledge were significantly associated with
self-medication practice. In addition, there are correctable gaps in program
designing, screening of pregnant women, regulatory enforcement, and strategies
and guidelines. Hence, necessary measures at all levels must be taken to reduce
risks of self-medication during pregnancy.
DOI: 10.1186/s41182-018-0091-z
PMCID: PMC5928590
PMID: 29743807
Author information:
(1)M.Sc. of Nursing, Faculty of Nursing and Midwifery, Isfahan (Khorasgan)
Branch, Islamic Azad University, Isfahan, Iran.
(2)Ph.D. of Nursing, Professor, Faculty member, Faculty of Nursing and Midwifery,
Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
(3)M.Sc. of Critical Care Nursing, Faculty member, Faculty of Nursing and
Midwifery, Young Researchers and Elite Club, Isfahan (Khorasgan) Branch, Islamic
Azad University, Isfahan, Iran.
INTRODUCTION: Drug overuse is a serious problem for health care, and one of the
biggest problems for the socio-economic well-being of different communities. The
elderly tend to use more drugs due to changes in their cognitive and
physiological factors. One of the best ways to evaluate the health level of
elderly people is to evaluate their self-medication. This study was conducted to
investigate self-medication among the elderly in Shahr-e-Kord.
METHODS: This cross-sectional study was conducted on 350 people older than 65 in
Shahr-e-Kord in 2015. Sampling was done in two stages. In the first stage, the
city of Shahr-e-Kord was divided into four areas using geographical maps.
Eighty-eight people were selected from each area. The research instrument was a
questionnaire called the Health Belief Model (HBM). The data were analyzed using
SPSS version 20, the chi-squared test, the independent-samples t-test, and the
Pearson correlation coefficient.
RESULTS: No significant relationship was observed between the prevalence of
self-medication with demographic variables and level of awareness. But there was
a significant difference between sensitivity, perceived severity, and perceived
barriers and educational level. There also was a significant difference between
the perceived benefits and their income level. There also was a significant
difference between the level of awareness, sensitivity, severity, benefits, and
barriers of people with and without a history of self-medication (p < 0.05).
CONCLUSION: Due to the adverse effects of self-medication and the high prevalence
of this activity among the elderly, it is recommended that a training program be
developed and implemented to change the knowledge and beliefs of the elderly
about self-medication.
DOI: 10.19082/3205
PMCID: PMC5217812
PMID: 28070253
Ali AS(1), Ahmed J(1), Ali AS(1), Sonekhi GB(1), Fayyaz N(1), Zainulabdin Z(2),
Jindani R(3).
Author information:
(1)Nursing Student, Bachelor of Science in Nursing, Dow University of Health
Sciences, Ojha Campus, Karachi, Pakistan.
(2)Nursing Student, Bachelor of Science in Nursing, Indus College of Nursing,
Islamic Mission Hospital, Karachi, Pakistan.
(3)Nursing Student, Master of Science in Nursing, Institute of Nursing, Dow
University of Health Sciences, Ojha Campus, Karachi, Pakistan.
Author information:
(1)Department of Oral and Maxillofacial Surgery, Paulista University - UNIP, São
Paulo, Brazil.
(2)Institute of Education and Research - IEP / Sírio Libanês Hospital, São Paulo,
Brazil.
(3)Piracicaba Dental School, State University of Campinas, Piracicaba, Brazil.
(4)Department of Dentistry, UNIEURO University Center, Brasília, Brazil.
(5)Instituto de Ensino e Pesquisa - IEP / Hospital Sírio Libanês, São Paulo,
Brazil.
(6)Department of Oral Diagnosis, Oral and Maxillofacial Surgery Division, State
University of Campinas, Piracicaba Dental School, Piracicaba, Brazil.
DOI: 10.2174/1874210601812010347
PMCID: PMC5958295
PMID: 29875887
Mohseni M(1), Azami-Aghdash S(2), Gareh Sheyklo S(3), Moosavi A(4), Nakhaee M(1),
Pournaghi-Azar F(5), Rezapour A(6)(7).
Author information:
(1)Department of Health Services Management, School of Health Management and
Information Sciences, Iran University of Medical Sciences, Tehran, Iran.
(2)Tabriz Health Services Management Research Center, Health Management and
Safety Promotion Research Institute, Tabriz University of Medical Sciences,
Tabriz, Iran.
(3)Department of Obstetrics and Gynecology, Dezful University of Medical
Sciences, Dezful, Iran.
(4)Department of Health and Community Medicine, Dezful University of Medical
Sciences, Dezful, Iran.
(5)Dental and Periodental Research Centre, Tabriz University of Medical Sciences,
Tabriz, Iran.
(6)Health Management and Economics Research Center, Iran University of Medical
Sciences, Tehran, Iran.
(7)Department of Health Economics, School of Health Management and Information
Sciences, Iran University of Medical Sciences, Tehran, Iran.
Background: Given the importance of having valid information about the prevalence
and reasons of self-medication among pregnant women for preventing
self-medication during this period, this study aimed to systematically review and
perform a meta-analysis on the prevalence and reasons of self-medication during
pregnancy.
Methods: This systematic review and meta-analysis was conducted in 2018 to
estimate the overall self-medication prevalence based on the database sources
PubMed, Scopus, Google Scholar, MagIran, IranMedex and SID. Required data were
collected using keywords: medication, self-medication, over-the-counter,
non-prescription, prevalence, etiology, and occurrence and pregnant. Descriptive
and cross-sectional studies in English and Persian languages were included. There
was no time limitation for search. R software was applied for meta-analysis.
Random-effects model was applied to estimate the self-medication prevalence with
95% confidence interval. Q statistics and I2 were used to measure the
heterogeneity.
Results: Out of 490 retrieved articles, finally 13 studies were included in
meta-analysis, 6 studies of which reported the cause of self-medication. The
overall estimated prevalence of self-medication based on the random effect model
was 32% (95% CI, 22% - 44%). The most important reasons of self-medication were
previous experience of the disease. The most important group of disease in which
patients self-medicated was anemia. Also, the most important group of medication
was herbal.
Conclusion: The results of this study showed that the prevalence of
self-medication among pregnant women was relatively high and required effective
interventions to reduce and prevent self-medication among this group. Providing
required information and raising awareness about complications resulting from
self-medication, in particular herbal medicines and dietary supplements, should
be taken into account.
PMCID: PMC6226611
PMID: 30465000
58. BMJ Case Rep. 2017 Aug 2;2017. pii: bcr-2017-219907. doi:
10.1136/bcr-2017-219907.
Author information:
(1)Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye
care, LV Prasad Eye Institute, Hyderabad, India.
We aim to highlight the prevalence of using local medications for curing eye
ailments in a rural population and the harmful consequence of resultant disease,
ranging from something as mild as conjunctivitis to sight-threatening conditions.
This case report will address one such incidence where in a local village, the
doctor known as a registered medical practitioner) in the rural community, uses
local remedies for his conjunctivitis and ends up in a condition where he cannot
see anything beyond perceiving light. The membrane removal and treatment with
topical antibiotic cured his infection, restoring complete recovery of vision.
This incidence inspired the local village doctor to become an eye health
educator. He was motivated to spread awareness about the ill effects of
self-medication on eye health. He is also determined to bring all blind people
and others who need eye care from his remote village to our centre.
© BMJ Publishing Group Ltd (unless otherwise stated in the text of the article)
2017. All rights reserved. No commercial use is permitted unless otherwise
expressly granted.
DOI: 10.1136/bcr-2017-219907
PMCID: PMC5614090
PMID: 28768670 [Indexed for MEDLINE]
Author information:
(1)Francesca Manzella, George T Taylor, Behavioral Neuroscience Program,
Department of Psychological Sciences, University of Missouri-St. Louis, St.
Louis, MO 63121, United States.
A common remark among laypeople, and notably also among mental health workers, is
that individuals with mental illnesses use drugs as self-medication to allay
clinical symptoms and the side effects of drug treatments. Roots of the
self-medication concept in psychiatry date back at least to the 1980s.
Observations that rates of smokers in schizophrenic patients are multiple times
the rates for regular smoking in the general population, as well as those with
other disorders, proved particularly tempting for a self-medication explanation.
Additional evidence came from experiments with animal models exposed to nicotine
and the identification of neurobiological mechanisms suggesting self-medication
with smoking is a plausible idea. More recently, results from studies comparing
smoking and non-smoking schizophrenic patients have led to the questioning of the
self-medication hypothesis. Closer examination of the literature points to the
possibility that smoking is less beneficial on schizophrenic symptomology than
generally assumed while clearly increasing the risk of cancer and other
smoking-related diseases responsible for early mortality. It is a good time to
examine the evidence for the self-medication concept as it relates to smoking.
Our approach is to focus on data addressing direct or implied predictions of the
hypothesis in schizophrenic smokers.
DOI: 10.5498/wjp.v5.i1.35
PMCID: PMC4369547
PMID: 25815253
Author information:
(1)Department of Nursing, College of Medicine and Health Sciences, Afe Babalola
University, Ado-Ekiti, Nigeria.
(2)Department of Public Health, College of Medicine and Health Sciences, Afe
Babalola University, Ado-Ekiti, Nigeria.
(3)Depatment of E.N.T., Federal Teaching Hospital, Ido-Ekiti, Nigeria.
(4)Department of Medical Microbiology and Parasitology, College of Medicine and
Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
DOI: 10.1155/2018/5439079
PMCID: PMC6317103
PMID: 30671097 [Indexed for MEDLINE]
Sarvet AL(1), Wall MM(2), Keyes KM(3), Olfson M(1), Cerdá M(4), Hasin DS(5).
Author information:
(1)Department of Psychiatry, College of Physicians and Surgeons, Columbia
University, 722 W 168(th) St., New York, NY 10032, USA; New York State
Psychiatric Institute, 722 W 168th St., New York, NY 10032, USA.
(2)Department of Psychiatry, College of Physicians and Surgeons, Columbia
University, 722 W 168(th) St., New York, NY 10032, USA; New York State
Psychiatric Institute, 722 W 168th St., New York, NY 10032, USA; Department of
Biostatistics, Mailman School of Public Health, Columbia University, 722 W 168th
St., New York, NY 10032, USA.
(3)Department of Psychiatry, College of Physicians and Surgeons, Columbia
University, 722 W 168(th) St., New York, NY 10032, USA; Department of
Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th
St., New York, NY 10032, USA.
(4)Department of Emergency Medicine, University of California, Davis, 2315
Stockton Blvd., Sacramento, CA 95817, USA.
(5)Department of Psychiatry, College of Physicians and Surgeons, Columbia
University, 722 W 168(th) St., New York, NY 10032, USA; New York State
Psychiatric Institute, 722 W 168th St., New York, NY 10032, USA; Department of
Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th
St., New York, NY 10032, USA. Electronic address: dsh2@cumc.columbia.edu.
DOI: 10.1016/j.drugalcdep.2018.01.009
PMCID: PMC5911228
PMID: 29525698 [Indexed for MEDLINE]
62. Int J Prev Med. 2015 Jul 20;6:66. doi: 10.4103/2008-7802.161264. eCollection
2015.
Author information:
(1)Department of Public Health, Khalkhal Faculty of Medical Sciences, Ardabil
University of Medical Sciences, Ardabil, Iran.
(2)Department of Health Education and Promotion, School of Health, Qom University
of Medical Sciences, Qom, Iran.
(3)Department of Plastic Surgery, Faculty of Medicine, Iran University of Medical
Sciences, Tehran, Iran.
(4)Department of Public Health, School of Health, Qom University of Medical
Sciences, Qom, Iran.
BACKGROUND: Although the frequency of self-medication has been well-documented in
the public health literature, but no study has examined the relationship between
health literacy and self-medication yet. This study was aimed to investigating
the relationship between health literacy and self-medication in a community-based
study.
METHODS: This cross-sectional study was conducted on 924 adults to survey
association between health literacy and self-medication among peoples in Ardabil
city in 2014 who were selected using a multi-stage random sampling method. Health
literacy was measured by the test of functional health literacy in adults and
general health status was measured by the 12-item General Health Questionnaire,
and self-reported self-medication (overall, sedative, antibiotic and herbal) in
last 3 months was assessed. All statistical analysis was performed using the SPSS
version 18 and a P < 0.05 was considered significant.
RESULTS: The mean age and weight of respondents were 37 years and 74.7 kg,
respectively. The prevalence of self-medication was 61.6%, and the percentage of
self-administering antibiotics, sedative, and herbal medicines were 40%, 54.4%,
and 59.1% in the last 3 months, respectively. Significant relationship was found
between of total health literacy and general health status with self-medication.
The prevalence of self-medication among participants with poor and very poor
self-rated physical and mental health was significantly higher than other
participants (P < 0.001).
CONCLUSIONS: Self-medication had a significant relationship with health literacy
and health status. Therefore, the design and implementation of training programs
are necessary to increase the perception on the risk of self-medication.
DOI: 10.4103/2008-7802.161264
PMCID: PMC4521301
PMID: 26288710
Author information:
(1)Department of Clinical Pharmacy, College of Pharmacy, King Saud University, PO
Box 2475, Riyadh 11451, Kingdom of Saudi Arabia. E-mail. haljadhey@ksu.edu.sa.
DOI: 10.15537/smj.2015.3.10523
PMCID: PMC4381018
PMID: 25737176 [Indexed for MEDLINE]
Author information:
(1)Boru Meda District Hospital, South Wollo Zone, Amhara Region, Southeast,
Ethiopia.
(2)University of Gondar, College of Medicine and Health Science, School of
Nursing, Gondar, Ethiopia.
(3)University of Gondar, College of Medicine and Health Science, School of
Nursing, Gondar, Ethiopia. habtsew@ymail.com.
DOI: 10.1186/s40360-018-0205-6
PMCID: PMC5894137
PMID: 29636092 [Indexed for MEDLINE]
Author information:
(1)Department of Nursing, School of Nursing and Midwifery, Kermanshah University
of Medical Sciences, Kermanshah, Iran.
(2)Social Development and Health Promotion Research Center, Kermanshah University
of Medical Sciences, Kermanshah, Iran. Akhatony@gmail.com.
DOI: 10.1186/s40360-018-0231-4
PMCID: PMC6029137
PMID: 29970167 [Indexed for MEDLINE]
Author information:
(1)Instituto Jenny de Andrade Faria de Atenção à Saúde do Idoso e da Mulher,
Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG,
Brazil.
(2)Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte,
MG, Brazil.
(3)Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte,
MG, Brazil.
OBJECTIVE: To determine the profile of medications used for self-medication by
the elderly.
METHODS: A cross-sectional study based on interviews with elderly seen at a
reference center for Elderly Health of a teaching hospital, from July 2014 to
July 2015. Clinical, demographic and pharmacotherapeutic data were collected.
RESULTS: A total of 170 elderly were interviewed, 85.9% female, and the median
age was 76 years. The frequency of self-medication was 80.5%. The most used
medications for self-medication were central acting muscle relaxants, analgesics
and antipyretics, non-steroidal anti-inflammatory and antirheumatic agents. Among
the elderly who practiced self-medication, 55.5% used drugs that were
inappropriate for the elderly, according to Beers criteria of 2015, and 56.9%
used medications that showed therapeutic duplicity with the prescribed drugs. We
identified 57 drugs used for self-medication, of which 30 (52.6%) were classified
as over-the-counter and 27 (47.4%) as prescription drugs. Approximately 68.6% of
elderly had at least one interaction involving drugs prescribed and those used
for self-medication.
CONCLUSION: The practice of self-medication was frequent in the elderly studied.
The widespread use of over-the-counter drugs and/or potentially inappropriate
medications for elderly increases the risk of drug interactions and adverse
events.
DOI: 10.31744/einstein_journal/2018AO4372
PMCID: PMC6276811
PMID: 30517365 [Indexed for MEDLINE]
Author information:
(1)Prof. Nahla Khamis Ibrahim, MBBS, MPH, DHPE, PhD.Family and Community Medicine
Department, King Abdulaziz University, Jeddah, Saudi Arabia. Epidemiology Dept.,
High Institute of Public Health,Alexandria University, Alexandria, Egypt.
(2)Dr. Banan Mohammad Alamoudi, MBBS. Family and Community Medicine Department,
King Abdulaziz University, Jeddah, Saudi Arabia.
(3)Dr. Wejdan Omar Baamer, MBBS. Intern, King Abdulaziz University, Jeddah, Saudi
Arabia.
(4)Dr. Rajaa Mohammad Al-Raddadi, MBBS, PhD. Consultant Community Medicine,
Ministry of Health, Jeddah, Saudi Arabia.
DOI: 10.12669/pjms.311.6526
PMCID: PMC4386150
PMID: 25878607
Author information:
(1)Department of Pharmacology and Toxicology, School of Pharmacy, College of
Health and Medical Sciences, Haramaya University, P.O. Box 235, Harar, Ethiopia.
mekonnensisay27@yahoo.com.
(2)Pharmacology Unit, Department of Pharmacy, College of Medicine and Health
Sciences, Wollo University, P.O. Box 1145, Dessie, Ethiopia.
(3)Department of Pharmacy Practice, School of Pharmacy, College of Health and
Medical Sciences, Haramaya University, P.O. Box 235, Harar, Ethiopia.
DOI: 10.1186/s40360-018-0248-8
PMCID: PMC6131789
PMID: 30201045 [Indexed for MEDLINE]
69. Pharmacy (Basel). 2018 Jan 15;6(1). pii: E6. doi: 10.3390/pharmacy6010006.
Seam MOR(1), Bhatta R(2), Saha BL(3), Das A(4), Hossain MM(5), Uddin SMN(6),
Karmakar P(7), Choudhuri MSK(8), Sattar MM(9).
Author information:
(1)Department of Pharmacy, Noakhali Science and Technology University, Sonapur,
Noakhali 3814, Bangladesh. omarrezaseam@gmail.com.
(2)Department of Pharmacy, Noakhali Science and Technology University, Sonapur,
Noakhali 3814, Bangladesh. phar_rita@yahoo.com.
(3)Department of Pharmacy, Noakhali Science and Technology University, Sonapur,
Noakhali 3814, Bangladesh. bijoylaxmi.saha@yahoo.com.
(4)Department of Pharmacy, Noakhali Science and Technology University, Sonapur,
Noakhali 3814, Bangladesh. abhijitdas@nstu.edu.bd.
(5)Department of Pharmacy, Noakhali Science and Technology University, Sonapur,
Noakhali 3814, Bangladesh. monirjupharmacy@gmail.com.
(6)Department of Pharmacy, University of Chittagong, Chittagong 4331, Bangladesh.
pharma.naim@yahoo.com.
(7)Department of Pharmacy, Noakhali Science and Technology University, Sonapur,
Noakhali 3814, Bangladesh. pk@nstu.edu.bd.
(8)Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342,
Bangladesh. mskchoudhuri@juniv.edu.
(9)Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342,
Bangladesh. mafruhi1968@yahoo.com.
DOI: 10.3390/pharmacy6010006
PMCID: PMC5874545
PMID: 29342983
Lukovic JA(1), Miletic V(2), Pekmezovic T(1), Trajkovic G(3), Ratkovic N(4),
Aleksic D(4), Grgurevic A(1).
Author information:
(1)Institute of Epidemiology, School of Medicine, University of Belgrade,
Belgrade, Serbia.
(2)Association for Mental Health Promotion, Belgrade, Serbia.
(3)Institute of Medical Statistics and Informatics, School of Medicine,
University of Belgrade, Belgrade, Serbia.
(4)Clinical Centre of Serbia, Belgrade, Serbia.
DOI: 10.1371/journal.pone.0114644
PMCID: PMC4263675
PMID: 25503967 [Indexed for MEDLINE]
Jambo A(1), Mengistu G(2), Sisay M(3), Amare F(1), Edessa D(1).
Author information:
(1)Department of Clinical Pharmacy, School of Pharmacy, College of Health and
Medical Sciences, Haramaya University, Harar, Ethiopia.
(2)Department of Pharmacy, College of Medicine and Health Sciences, Wollo
University, Dessie, Ethiopia.
(3)Department of Pharmacology and Toxicology, School of Pharmacy, College of
Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
DOI: 10.3389/fphar.2018.01063
PMCID: PMC6178140
PMID: 30337871
72. Depress Anxiety. 2018 Sep;35(9):851-860. doi: 10.1002/da.22771. Epub 2018 Jul
12.
Self-medication with alcohol or drugs for mood and anxiety disorders: A narrative
review of the epidemiological literature.
Author information:
(1)Department of Psychiatry and Community Health Sciences, University of
Manitoba, Winnipeg, Manitoba, Canada.
(2)Department of Clinical Health Psychology, University of Manitoba, Winnipeg,
Manitoba, Canada.
(3)Department of Psychiatry, Psychology and Community Health Sciences, Winnipeg,
Manitoba, Canada.
BACKGROUND: The comorbidity of mood and anxiety disorders (MD and AD) with
substance use disorders (SUD) is common. One explanation for this comorbidity is
the self-medication hypothesis, which posits that individuals with MD or AD use
substances to cope with the difficult symptoms associated with the disorder. Over
time, self-medication (SM) can develop into an independent SUD. This narrative
review will present the prevalence and correlates of SM with alcohol and/or drugs
for MD and AD and the relationship between SM and subsequent SUD using both
cross-sectional and longitudinal epidemiological data.
METHODS: Scopus and PsycINFO were searched from January 1997 to April 2018 to
identify original research articles that examined the prevalence and correlates
of SM and the temporal relationship between MD/AD and SUD in the general
population (n = 22).
RESULTS: The prevalence of SM with alcohol and/or drugs among those with MD or AD
ranged from 21.9% to 24.1%. Male sex, younger age, being separated, divorced or
widowed, and being Caucasian were characteristics associated with higher
proportions of respondents endorsing SM with alcohol/drugs for MD and AD.
Longitudinal data supports the temporal onset of primary MD/AD and secondary SUD
among those who self-report SM.
CONCLUSION: Providing and promoting alternate coping strategies for those with
MD/AD may reduce SM, the development of SUD, and the comorbidity of MD/AD with
SUD. The concurrent treatment of MD/AD and substance use is the current "gold
standard" model of care, and the results of this review support its use.
© 2018, The Authors. Depression and Anxiety published by Wiley Periodicals, Inc.
DOI: 10.1002/da.22771
PMCID: PMC6175215
PMID: 29999576 [Indexed for MEDLINE]
Marwa KJ(1), Njalika A(2), Ruganuza D(3), Katabalo D(2), Kamugisha E(4).
Author information:
(1)Department of Pharmacology, Catholic University of Health and Allied Sciences,
Mwanza, Tanzania. carol_maro@yahoo.com.
(2)School of Pharmacy, Catholic University of Health and Allied Sciences, Mwanza,
Tanzania.
(3)Department of Parasitology, Catholic University of Health and Allied Sciences,
Mwanza, Tanzania.
(4)Department of Biochemistry, Catholic University of Health and Allied Sciences,
Mwanza, Tanzania.
DOI: 10.1186/s12884-017-1642-8
PMCID: PMC5759229
PMID: 29310609 [Indexed for MEDLINE]
Author information:
(1)Center for Interdisciplinary Research Egas Moniz (CiiEM). Almada ( Portugal ).
ana.pd.nunes@gmail.com.
(2)Institute of Health Sciences Egas Moniz (ISCSEM). Center for Interdisciplinary
Research Egas Moniz (CiiEM). Almada ( Portugal ). imargaridac@gmail.com.
(3)Institute of Health Sciences Egas Moniz (ISCSEM). Center for Interdisciplinary
Research Egas Moniz (CiiEM). Almada ( Portugal ). Alvesdacosta.f@gmail.com.
DOI: 10.18549/PharmPract.2016.01.648
PMCID: PMC4800012
PMID: 27011773
Senadheera GP, Sri Ranganathan Sh, Gunawardane NS, Fernando GH, Fernandopulle BM.
DOI: 10.4038/cmj.v62i1.8439
PMID: 28390337
The self medication use among adolescents aged between 13-18 years old;
Prevalence and behavior, Riyadh - Kingdom of Saudi Arabia, from 2014-2015.
Albatti TH(1), Alawwad S(2), Aldueb R(2), Alhoqail R(2), Almutairi R(2).
Author information:
(1)Child and Adolescents Psychiatry Department, King Khalid University Hospital,
Saudi Arabia.
(2)College of Medicine, King Saud University, Saudi Arabia.
Background and objectives: In Saudi Arabia, people have easy access to medication
and can purchase prescribed medications, such as anti-acne medications and
antibiotics, over the counter without the need for a prescription from a
physician.Our research is focused on estimating the prevalence of self-medication
and understanding the reason for self-medication because previous studies have
shown an increase in the practice of self-medication globally and locally.The aim
of this study is to estimate the prevalence of self-medication among adolescents
aged 13-18 years of both genders in Riyadh, Saudi Arabia. In addition, we aim to
identify the indications and external and internal factors behind
self-medication, including the effects of gender, peer influence and parental
supervision on the decision of adolescents to self-medicate.
Patients and Methods: An observational and cross-sectional adolescent-based study
was performed to estimate the degree of self-medication among 400 intermediate
and high school students in private and governmental schools living in Riyadh
between 2014 and 2015 using a multistage random sampling technique. A validated
self-administered questionnaire was used for data collection, and data were
tabulated and analyzed with the SPSS version 21 computer program.
Results: We found that the rate of self-medication among adolescents was high
(94.5%). Analgesics were the most common medication used (87.3%), and the least
common medication used was hormones (5%). A majority of the students reported
that headache was the reason for using analgesics. The sources of the medications
included the pharmacy (51.64%), followed by parents (34.33%). The results showed
that self-medication was significantly associated with the type of school that
the adolescents attended (P < 0.011) and the health status of the adolescents (P
-value <0.035).
Conclusion: Self-medication is highly prevalent in Riyadh, particularly among
adolescents. Easy access to pharmacies was found to be the leading cause for
self-medication. The use of these drugs was associated with inappropriate drug
use and the deterioration of health status. Self-medication should be closely
monitored and awareness should be increased with educational programs among
students.
DOI: 10.1016/j.ijpam.2016.05.001
PMCID: PMC6372571
PMID: 30805495
77. Pharmacy (Basel). 2018 Feb 1;6(1). pii: E15. doi: 10.3390/pharmacy6010015.
Patterns of Self-Medication Behavior for Oral Health Problems Among Adults Living
in Riyadh, Saudi Arabia.
Aldeeri A(1), Alzaid H(2), Alshunaiber R(3), Meaigel S(4), Shaheen NA(5)(6),
Adlan A(7)(8).
Author information:
(1)College of Dentistry, Riyadh Elm University, Riyadh 12734, Saudi Arabia.
ArwaAldeeri@gmail.com.
(2)College of Dentistry, Riyadh Elm University, Riyadh 12734, Saudi Arabia.
HayaAlzaid@gmail.com.
(3)College of Dentistry, King Saud Bin-Abdulaziz University for Health Sciences,
Riyadh 14811, Saudi Arabia. RenadAbdullaziz@gmail.com.
(4)College of Dentistry, King Saud Bin-Abdulaziz University for Health Sciences,
Riyadh 14811, Saudi Arabia. ShahadMeaigel@gmail.com.
(5)Department of Biostatistics and Bioinformatics, King Abdullah International
Medical Research Center, Riyadh 14611, Saudi Arabia. AshrafNa@ngha.med.sa.
(6)King Saud Bin-Abdulaziz University for Health Sciences, Riyadh 14811, Saudi
Arabia. AshrafNa@ngha.med.sa.
(7)King Saud Bin-Abdulaziz University for Health Sciences, Riyadh 14811, Saudi
Arabia. AdlanA@ngha.med.sa.
(8)Department of Biomedical Ethics, King Abdullah International Medical Research
Center, Riyadh 14611, Saudi Arabia. AdlanA@ngha.med.sa.
DOI: 10.3390/pharmacy6010015
PMCID: PMC5874554
PMID: 29389869
Author information:
(1)Department of Pharmacology, All India Institute of Medical Sciences, New
Delhi, India.
(2)Department of Pharmacology, All India Institute of Medical Sciences,
Bhubaneswar, Odisha, India.
DOI: 10.4103/0976-9668.184700
PMCID: PMC4934103
PMID: 27433064
79. PLoS One. 2017 Aug 22;12(8):e0183461. doi: 10.1371/journal.pone.0183461.
eCollection 2017.
Gupta N(1), Vashist P(1), Tandon R(1), Gupta SK(2), Kalaivani M(3), Dwivedi
SN(3).
Author information:
(1)Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of
Medical Sciences, New Delhi, India.
(2)Centre for Community Medicine, All India Institute of Medical Sciences, New
Delhi, India.
(3)Department of Biostatistics, All India Institute of Medical Sciences, New
Delhi, India.
OBJECTIVE: To determine the type and nature of traditional eye medicine (TEM),
their sources and use and practices related to self-medication for ophthalmic
diseases in a rural Indian population.
METHODS: A population-based, cross-sectional study was conducted in 25 randomly
selected clusters of Rural Gurgaon, Haryana, India as part of CORE (Cornea
Opacity Rural Epidemiological) study. In addition to comprehensive ophthalmic
examination, health-seeking behavior and use of self-medication and TEM was
assessed in the adult population using a semi-structured questionnaire. Physical
verification of available ophthalmic medications in the enumerated households was
conducted by the study team. Descriptive statistics were computed along with
multivariable logistic regression analysis to determine associated factors for
use of self-medication and TEM.
RESULTS: Of the 2160 participants interviewed, 396 (18.2%) reported using
ophthalmic medications without consulting an ophthalmologist, mainly for symptoms
like watering (37.1%), redness (27.7%), itching (19.2%) and infection (13.6%). On
physical verification of available eye drops that were being used without
prescription, 26.4% participants were practicing self-medication. Steroid,
expired/unlabeled and indigenous eye drops were being used by 151(26.5%),
120(21.1%) and 75 (13.2%) participants respectively. Additionally, 25.7% (529)
participants resorted to home remedies like 'kajal'(61.4%), honey (31.4%), ghee
(11.7%) and rose water (9.1%).
CONCLUSION: Use of TEM is prevalent in this population. The rampant use of
steroid eye drops without prescription along with use of expired or unlabelled
eye drops warrants greater emphasis on safe eye care practices in this
population. Public awareness and regulatory legislations must be implemented to
decrease harmful effects arising due to such practices.
DOI: 10.1371/journal.pone.0183461
PMCID: PMC5567472
PMID: 28829812 [Indexed for MEDLINE]
DOI: 10.1136/ejhpharm-2015-000733
PMCID: PMC6451461
PMID: 31156941
Mittal P(1), Chan OY(1), Kanneppady SK(2), Verma RK(1), Hasan SS(3)(4).
Author information:
(1)Department of Pharmacy Practice, International Medical University, Kuala
Lumpur, Malaysia.
(2)School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.
(3)Department of Pharmacy, University of Huddersfield, Huddersfield, West
Yorkshire, United Kingdom.
(4)School of Biological Sciences and Pharmacy, University of Newcastle,
Newcastle, New South Wales, Australia.
DOI: 10.1371/journal.pone.0201776
PMCID: PMC6072109
PMID: 30071006 [Indexed for MEDLINE]
Author information:
(1)Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
(2)Department of Primary Care, Netherlands Institute for Health Services Research
(NIVEL), Utrecht, Netherlands.
(3)Department of General Practice and Elderly Care Medicine, Netherlands
Institute for Health Services Research (NIVEL), Utrecht, Netherlands.
(4)EMGO Institute for Health and Care Research, VU University Medical Center
Amsterdam, Amsterdam, Netherlands.
DOI: 10.3389/fpubh.2018.00370
PMCID: PMC6304439
PMID: 30619809
Author information:
(1)Department of Rheumatology, Yalgado Ouedraogo University Hospital,
Ouagadougou, Burkina Faso.
(2)Department of Rheumatology, Sylvanus Olympio University Hospital, Lomé, Togo.
(3)Department of Internal Medicine, Yalgado Ouedraogo University Hospital,
Ouagadougou, Burkina Faso.
(4)Department of Clinical Pharmacology, Yalgado Ouedraogo University Hospital,
Ouagadougou, Burkina Faso.
DOI: 10.5152/eurjrheum.2015.0091
PMCID: PMC5047262
PMID: 27708926
84. Dermatol Res Pract. 2017;2017:7521831. doi: 10.1155/2017/7521831. Epub 2017 Nov
12.
Kombaté K(1), Técléssou JN(1), Saka B(1), Akakpo AS(1), Tchangai KO(1),
Mouhari-Toure A(2), Mahamadou G(1), Gnassingbé W(1), Abilogun-Chokki A(1), Pitché
P(1).
Author information:
(1)Service de Dermatologie et IST, CHU Lomé, Université de Lomé, Lomé, Togo.
(2)Service de Dermatologie et IST, CHU de Kara, Université de Kara, Kara, Togo.
Objective: This study aimed to determine the prevalence of and factors associated
with self-medication in dermatology in Lomé, Togo.
Methods: We conducted an analytical cross-sectional study from February to April
2016 in 2 dermatology departments in Lomé. Univariate and multivariate logistic
regression models were carried out to identify possible factors associated with
self-medication.
Results: A total of 711 patients were included in the study. The mean age (±SD)
of the patients was 26.6 ± 6.9 years and the sex ratio (male/female) was 0.6. The
main dermatologic diseases recorded were immunoallergic dermatoses (39.7%) and
infectious skin diseases (22.6%). Two-thirds (481/711; 66.7%) of the patients had
practiced self-medication before consultation in dermatology units. In
multivariate analysis, factors associated with self-medication were female sex
(aOR = 1.44; 95% CI = [1.01, 2.05]), duration of dermatologic disease more than
one year (aOR = 1.79; IC = [1.19, 2.68]), adnexal dermatoses (aOR = 2.31; 95% IC
= [1.03-5.21]), keratinization disorders (aOR = 4.23; 95% CI = [1.36-13.13]), and
fungal skin infections (aOR = 5.43; 95% CI = [2.20, 13.38]).
Conclusion: Our study confirms that self-medication practice is very common among
patients with dermatologic diseases in Lomé and has identified associated
factors.
DOI: 10.1155/2017/7521831
PMCID: PMC5702392
PMID: 29259625
Author information:
(1)Department of Epidemiology, High Institute of Public Health, University of
Alexandria, Alexandria, Egypt.
(2)Department of Biostatistics, High Institute of Public Health, University of
Alexandria, Alexandria, Egypt. imanwahdan@yahoo.com.
(3)Department of Primary Health Care, High Institute of Public Health, University
of Alexandria, Alexandria, Egypt.
This study aimed to describe the prevalence, pattern and reasons for
self-medication among adults in Alexandria, Egypt. In a community-based survey
during 2012, a representative sample of 1100 adults completed a predesigned
interview questionnaire on self-medication practices by drugs and complementary
or alternative medicines (CAM). A majority of them practised self-medication
(86.4%), mostly using both drugs and CAM (77.5%). The most commonly used drugs
were analgesics (96.7%), and cough and cold preparations (81.9%), but 53.9% of
respondents reported self-medication with antibiotics. The most frequently used
CAM were herbs (91.6%), followed by spiritual healing (9.4%) and cupping and
acupuncture (6.4%). CAM improved the condition according to 95.2% of users.
Logistic regression analysis revealed that age, occupation and the presence of
chronic conditions were the independent factors significantly affecting the
practice of self-medication with drugs.
Author information:
(1)Mental Illness Research Education and Clinical Center, Richmond Veterans
Affairs Medical Center.
(2)University of Virginia.
(3)Division of Mental Health, Norwegian Institute of Public Health.
(4)Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral
Genetics, Virginia Commonwealth University.
DOI: 10.1037/adb0000185
PMCID: PMC5114150
PMID: 27269293 [Indexed for MEDLINE]
Author information:
(1)Department of Health Insurance, Ministry of Health of Vietnam, Hanoi 100000,
Vietnam.
(2)Department of Planning and Financing, Ministry of Health of Vietnam, Hanoi
100000, Vietnam.
(3)Department of Pharmacoeconomics and Management, Hanoi University of Pharmacy,
Hanoi 100000, Vietnam.
Background: Monitoring self-medication practice, which refers to individuals
using medicine without instructions of physicians, is critical to control its
harmful effects. However, in Vietnam, evidence about self-medication among
individuals in highland areas is constrained. This study examined self-medication
practice among residents living in highland areas in Vietnam and determined
associated factors. Materials and methods: A cross-sectional study was performed
in five highland provinces with 1000 individuals. Information about individual
and household's socioeconomic status and self-medication practice in the last 12
months was surveyed. Multivariate logistic and Poisson regressions were used to
identify associated factors with self-medication. Results: 83.3% reported
self-medication in the last 12 months, with the mean times of self-medication
being 4.5 times (SD=4.1). Female (OR=0.62, p<0.01), ethnic minorities, higher
number of members having health insurance in family (OR=0.82, p<0.01) and higher
annual household income (OR=0.78, p<0.05) were associated with the lower
likelihood of "Only buy medicines at pharmacy stores when having illness in the
last 12 month". Moreover, people who were females (OR=0.59, p<0.05), white-collar
worker (OR=0.25, p<0.01) and had higher number of children in the family
(OR=0.68, p<0.05) were less likely to practice self-medication. People who were
ethnic minorities, white-collar worker (Coef.=-0.32, p<0.01) and higher number of
members having health insurance in family had lower times of self-medication in
the last 12 months compared to other groups. Meanwhile, individuals having higher
number of members in the family (Coef.=0.07, p<0.01) and higher annual household
income (Coef.=0.08, p<0.01) had highertimes of self-medication in the last 12
months. Conclusion: Residents in highland areas in Vietnam had a considerably
high 12-month prevalence of self-medication. Medical products quality management
and self-medication guideline are potential to maximize the effects of
self-medication. Moreover, promoting the use of health insurance should also be
concerned as a solution to address this issue.
DOI: 10.2147/JMDH.S211420
PMCID: PMC6620316
PMID: 31456640
Author information:
(1)From the University of Utah (ELG, EAT), Salt Lake City, UT; Florida State
University (AWH), Tallahassee, FL; and Tallahassee Memorial Hospital Recovery
Center (PK, JF), Tallahassee, FL.
DOI: 10.1097/ADM.0000000000000090
PMCID: PMC4310788
PMID: 25469652 [Indexed for MEDLINE]
Author information:
(1)Ghana Health Service, School of Pharmacy, University of Ghana, Accra, Ghana.
(2)USAID|DELIVER Project, School of Pharmacy, University of Ghana, Accra, Ghana.
(3)Ghana Police Hospital, School of Pharmacy, University of Ghana, Accra, Ghana.
(4)Department of Pharmacology and Toxicology, School of Pharmacy, University of
Ghana, Accra, Ghana.
Banerjee I(1), Sathian B(2), Gupta RK(3), Amarendra A(4), Roy B(5),
Bakthavatchalam P(6), Saha A(7), Banerjee I(8).
Author information:
(1)Assistant Professor, Department of Pharmacology, SSR Medical College, Belle
Rive, Mautitius, ; Assistant Professor, Department of Pharmacology, Manipal
College of Medical Sciences, Pokhara, Nepal.
(2)Assistant Professor, Department of Community Medicine, Manipal College of
Medical Sciences, Pokhara, Nepal.
(3)Professor and Head of the Department, Department of Pharmacology, SSR Medical
College, Belle Rive, Mautitius.
(4)Lecturer, Department of Pharmacology, SSR Medical College, Belle Rive,
Mautitius.
(5)Assistant Professor, Department of Physiology, Manipal College of Medical
Sciences, Pokhara, Nepal.
(6)Lecturer, Faculty of medicine, Quest International University, Perek,
Malaysia.
(7)Professor and Head of the Department, Department of Pharmacology, Manipal
College of Medical Sciences, Pokhara, Nepal.
(8)Post Doctorate Trainee, M.Ch Urology, SMS Medical College, Rajasthan, India.
BACKGROUND: In developing countries like Nepal medicines can be acquired from the
chemist's without of a prescription which sometime may have many drawbacks due to
intake of excessive drugs without a proper diagnosis. The primary objective of
the study was to find out the pattern of self-medication practice among the
preclinical medical students at Manipal College of Medical Sciences.
MATERIALS AND METHODS: This was a cross sectional study carried out using
structured questionnaire at Manipal College of Medical Sciences, Pokhara, Nepal
between November 2012- July 2014.
RESULTS: The overall response rate of this study was 95.31%. 81.35% of the
students were practicing self-medication in this institution. Most common group
of drugs that were consumed were antipyretics 31%, antibiotics 26.2%, analgesics
18.89%, antihistaminics 10.1% respectively. Paracetamol was the most common drug
used for self-medication 31%, followed by Azithromycin 17.6% and combination of
Paracetamol and Ibuprofen 15.6%, Cetirizine 8.6%, Amoxicillin 6.5%, Omeprazole
6.3%, Albendazole 3.3%, Mefenemic acid 2.8%, Cefpodoxime2% respectively.
CONCLUSION: Medical student should be educated through awareness programme
regarding pros and cons of self-medication practice and they should be motivated
regarding the rationale use of antibiotics. .
DOI: 10.3126/nje.v6i2.15165
PMCID: PMC5073175
PMID: 27774346
Author information:
(1)Department of Forensic Medicine, N. K. P. Salve Institute of Medical Sciences
and Research Centre, Digdoh Hills, Hingana Road, Nagpur-440 019, India.
(2)Department of Biochemistry, N. K. P. Salve Institute of Medical Sciences and
Research Centre, Digdoh Hills, Hingana Road, Nagpur-440 019, India.
PMCID: PMC4442466
PMID: 26009650
Author information:
(1)Department of Pharmaceutical Chemistry, Universidad del Valle de Guatemala,
Guatemala City, Guatemala. bramay@uvg.edu.gt.
(2)Department of Pharmaceutical Chemistry, Universidad del Valle de Guatemala,
Guatemala City, Guatemala. lambourpaola@gmail.com.
(3)Department of Anthropology, University of Denver, Denver, Colorado, USA.
alejandro.ceronvaldes@du.edu.
DOI: 10.1186/s40360-015-0011-3
PMCID: PMC4418049
PMID: 25928897 [Indexed for MEDLINE]
Author information:
(1)Department of Internal Medicine, İstanbul University Cerrahpaşa School of
Medicine, İstanbul, Turkey.
(2)Institute of Forensic Sciences, İstanbul University, Istanbul, Turkey.
DOI: 10.5152/balkanmedj.2016.150307
PMCID: PMC5056662
PMID: 27761287
Author information:
(1)Post Graduate Resident, Department of Pharmacology, M.R. Medical College ,
Gulbarga, Karnataka, India .
(2)Professor and Head, Department of Pharmacology, M.R. Medical College ,
Gulbarga, Karnataka, India .
(3)Professor, Department of Pharmacology, M.R. Medical College , Gulbarga,
Karnataka, India .
(4)Associate Professor, Department of Pharmacology, M.R. Medical College ,
Gulbarga, Karnataka, India .
(5)Assistant Professor, Department of Pharmacology, M.R. Medical College ,
Gulbarga, Karnataka, India .
DOI: 10.7860/JCDR/2014/10579.5313
PMCID: PMC4316275
PMID: 25653969
Sridhar SB(1), Shariff A(1), Dallah L(2), Anas D(2), Ayman M(2), Rao PG(1).
Author information:
(1)Department of Clinical Pharmacy and Pharmacology, RAK Medical and Health
Sciences University, Ras Al-Khaimah, UAE.
(2)RAK College of Pharmaceutical Sciences, RAK Medical and Health Sciences
University, Ras Al-Khaimah, UAE.
Aim: The aim of this study is to assess the nature, reasons, and consequences of
self-medication practice among the general population of Ras Al-Khaimah, UAE.
Materials and Methods: This was a prospective, cross-sectional, survey-based
study. Data with respect to knowledge, awareness, and practices regarding
self-medication were collected through an interviewer-assisted questionnaire
answered by the study participants. Thus, collected data from 413 survey
respondents were analyzed using SPSS version 24.0.
Results: The prevalence of self-medication practices among our study respondents
was 52.1%. A headache (155 [37.5%]) was the most common clinical condition
treated through self-medication practice. Familiarity with the
treatment/medication (198 [48%]) was the most common cited reasons, whereas the
advertisement and friend's advice were the most (182 [44%]) cited sources of
information for self-medication usage. The majority (265 [64.1%]) of the
respondents were considered self-medication practice as safe. However, 19
respondents reported side-effects or complications during the due course of
self-medication. It was observed that there is a statistically significant
association (P < 0.05) between age and employment status of this study
participants with self-medication practices.
Conclusion: The data from this study show that the self-medication practice is
very common among the study population. Variables such as younger age group and
occupation status were significantly associated with self-medication practice. We
emphasize the role of pharmacist in educating the community regarding safe
medication practices such as harmful effects of self-medicating and inappropriate
practices such as sharing the medications among family members and friends.
DOI: 10.4103/ijabmr.IJABMR_46_17
PMCID: PMC5846215
PMID: 29552527
Author information:
(1)Department of Microbiology, Immunology and Molecular Biology, Kilimanjaro
Christian Medical University College, Moshi, Kilimanjaro, Tanzania.
(2)Department of Microbiology, Immunology and Molecular Biology, Kilimanjaro
Clinical Research Institute, Moshi, Kilimanjaro, Tanzania.
(3)Department of Preventive Medicine and Research, Lugalo General Military
Hospital, Dar es Salaam, Tanzania.
(4)Department of Public Health and Research, Ifakara Health Institute, Dar es
Salaam, Tanzania.
(5)Department of Parasitology and Entomology, National Health Laboratory Quality
Assurance and Training Centre, Dar es Salaam, Tanzania.
(6)Department of Microbiology and Immunology, Catholic University of Health and
Allied Sciences, Mwanza, Tanzania.
(7)Department of Paediatrics and Child Health, Kilimanjaro Christian Medical
Centre, Moshi, Kilimanjaro, Tanzania.
DOI: 10.1371/journal.pone.0206623
PMCID: PMC6209340
PMID: 30379961 [Indexed for MEDLINE]
Douine M(1)(2), Lazrek Y(3), Blanchet D(4), Pelleau S(3), Chanlin R(4), Corlin
F(1), Hureau L(1), Volney B(3), Hiwat H(5), Vreden S(6), Djossou F(2)(7), Demar
M(2)(4), Nacher M(1)(2), Musset L(3).
Author information:
(1)Centre d'Investigation Clinique Antilles-Guyane (Inserm 1424), Cayenne
Hospital, French Guiana.
(2)Epidemiology of Tropical Parasitoses, EA 3593, Université de Guyane, Cayenne,
French Guiana.
(3)Laboratoire de Parasitologie, WHO Collaborating Center for Surveillance of
Anti-Malarial Drug Resistance, Centre National de Référence du Paludisme,
Institut Pasteur de la Guyane, Cayenne, French Guiana.
(4)Academic Laboratory of Parasitology - Mycology, Cayenne Hospital, Cayenne,
French Guiana.
(5)Ministry of Health, Malaria Program, Paramaribo, Suriname.
(6)Foundation for Scientific Research Suriname (SWOS), Paramaribo, Suriname.
(7)Infectious and Tropical Diseases Department, Cayenne Hospital, Cayenne, French
Guiana.
Background: Malaria is endemic in French Guiana (FG), South America. Despite the
decrease in cases in the local population, illegal gold miners are very affected
by malaria (22.3% of them carried Plasmodium spp.). Self-medication seems to be
very common, but its modalities and associated factors have not been studied. The
aim of this study was to evaluate parasite susceptibility to drugs and to
document behaviours that could contribute to resistance selection in illegal gold
miners.
Methods: This multicentric cross-sectional study was conducted in resting sites
along the FG-Surinamese border. Participating gold miners working in FG completed
a questionnaire and provided a blood sample.
Results: From January to June 2015, 421 illegal gold miners were included. Most
were Brazilian (93.8%) and 70.5% were male. During the most recent malaria
attack, 45.5% reported having been tested for malaria and 52.4% self-medicated,
mainly with artemisinin derivatives (90%). Being in FG during the last malaria
attack was the main factor associated with self-medication (adjusted OR = 22.1).
This suggests that access to malaria diagnosis in FG is particularly difficult
for Brazilian illegal gold miners. Treatment adherence was better for persons who
reported being tested. None of the 32 samples with Plasmodium falciparum
presented any mutation on the pfK13 gene, but one isolate showed a resistance
profile to artemisinin derivatives in vitro.
Conclusions: The risk factors for the selection of resistance are well known and
this study showed that they are present in FG with persons who self-medicated
with poor adherence. Interventions should be implemented among this specific
population to avoid the emergence of artemisinin resistance.
© The Author 2017. Published by Oxford University Press on behalf of the British
Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions,
please email: journals.permissions@oup.com.
DOI: 10.1093/jac/dkx343
PMID: 29045645 [Indexed for MEDLINE]
Author information:
(1)Department of Pharmacy Administration and Clinical Pharmacy, School of
Pharmacy, Xi'an Jiaotong University, Xi'an, China.
(2)Center for Drug Safety and Policy Research, Xi'an Jiaotong University, Xi'an,
China.
(3)School of Business, Dalian University of Technology, Panjin, China.
© Article author(s) (or their employer(s) unless otherwise stated in the text of
the article) 2017. All rights reserved. No commercial use is permitted unless
otherwise expressly granted.
DOI: 10.1136/bmjopen-2017-017306
PMCID: PMC5778336
PMID: 29259056 [Indexed for MEDLINE]
99. Version 3. F1000Res. 2015 Mar 19 [revised 2015 May 26];4:73. doi:
10.12688/f1000research.6262.2. eCollection 2015.
Author information:
(1)Department of Biological and Experimental Psychology, School of Biological and
Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1
4NS, UK.
(2)School of Biological Sciences, Royal Holloway University of London, Egham,
Surrey, TW20 0EX, UK.
DOI: 10.12688/f1000research.6262.2
PMCID: PMC4406194
PMID: 25949807
Karimy M(1), Rezaee-Momtaz M(2), Tavousi M(3), Montazeri A(3), Araban M(4)(5).
Author information:
(1)Social Determinants of Health Research Center, Saveh University of Medical
Sciences, Saveh, Iran.
(2)Department of Health Education and Promotion, Public Health School, Ahvaz
Jundishapur University of Medical Sciences, Ahvaz, Iran.
(3)Health Metrics Research Center, Iranian Institute for Health Sciences
Research, ACECR, Tehran, Iran.
(4)Department of Health Education and Promotion, Public Health School, Ahvaz
Jundishapur University of Medical Sciences, Ahvaz, Iran. arabanm@ajums.ac.ir.
(5)Social Determinants of Health Research Center, Ahvaz Jundishapur University of
Medical Sciences, Ahvaz, Iran. arabanm@ajums.ac.ir.
DOI: 10.1186/s12889-019-7302-3
PMCID: PMC6676788
PMID: 31370891
Author information:
(1)Medical Doctors Research Group (MDRG), Douala 15161, Cameroon.
crolandn@cbchealthservices.org.
(2)Mboppi Baptist Hospital Douala, Douala 15161, Cameroon.
crolandn@cbchealthservices.org.
(3)Health and Human Development (2HD) Research Network, Douala 4856, Cameroon.
crolandn@cbchealthservices.org.
(4)Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK.
crolandn@cbchealthservices.org.
(5)Medical Doctors Research Group (MDRG), Douala 15161, Cameroon.
vitalfeteh@gmail.com.
(6)Health and Human Development (2HD) Research Network, Douala 4856, Cameroon.
vitalfeteh@gmail.com.
(7)Medical Doctors Research Group (MDRG), Douala 15161, Cameroon.
belmondkika@gmail.com.
(8)District Hospital Ekondo-Titi, Ekondo-Titi 281, Cameroon.
belmondkika@gmail.com.
(9)Medical Doctors Research Group (MDRG), Douala 15161, Cameroon.
emadenericek@gmail.com.
(10)Mboppi Baptist Hospital Douala, Douala 15161, Cameroon.
emadenericek@gmail.com.
(11)School of Public Health ⁻ University of Brussels, Brussels CP 598, B-1070,
Belgium. emadenericek@gmail.com.
(12)Medical Doctors Research Group (MDRG), Douala 15161, Cameroon.
ayeahmarkchiatoh@yahoo.com.
(13)Mboppi Baptist Hospital Douala, Douala 15161, Cameroon.
ayeahmarkchiatoh@yahoo.com.
(14)Mboppi Baptist Hospital Douala, Douala 15161, Cameroon.
chifor.terry@gmail.com.
(15)Health and Human Development (2HD) Research Network, Douala 4856, Cameroon.
tsi.njim@lstmed.ac.uk.
(16)Department of International Public Health, Liverpool School of Tropical
Medicine, Liverpool L3 5QA, UK. tsi.njim@lstmed.ac.uk.
(17)Mboppi Baptist Hospital Douala, Douala 15161, Cameroon.
manuelafankem@gmail.com.
(18)Mboppi Baptist Hospital Douala, Douala 15161, Cameroon. faiyo.fy@gmail.com.
DOI: 10.3390/diseases6020049
PMCID: PMC6023369
PMID: 29890712
102. J Sports Sci Med. 2016 May 23;15(2):387-8. eCollection 2016 Jun.
Locquet M(1), Beaudart C(1), Larbuisson R(2), Buckinx F(1), Kaux JF(3), Reginster
JY(4), Bruyère O(1).
Author information:
(1)Department of Public Health, Epidemiology and Health Economics, University of
Liège, Belgium; Support Unit in Epidemiology and Biostatistics, University of
Liège , Belgium.
(2)Department of Anesthesiology-Reanimation, University of Liège , Belgium.
(3)Department of Physical Medicine and Sport Traumatology, University of Liège,
Belgium; Department of Motricity Sciences, University of Liège , Belgium.
(4)Department of Public Health, Epidemiology and Health Economics, University of
Liège , Belgium.
PMCID: PMC4879456
PMID: 27274680
103. BMC Health Serv Res. 2016 May 13;16:179. doi: 10.1186/s12913-016-1425-3.
Brata C(1)(2), Fisher C(3), Marjadi B(4), Schneider CR(5), Clifford RM(6).
Author information:
(1)Centre of Medicine Information and Pharmaceutical Care, The University of
Surabaya, Surabaya, Indonesia. cecilia.brata@gmail.com.
(2)Pharmacy, School of Medicine and Pharmacology, The University of Western
Australia, Perth, Australia. cecilia.brata@gmail.com.
(3)School of Population Health, The University of Western Australia, Perth,
Australia.
(4)School of Medicine, The University of Western Sydney, Campbelltown, Australia.
(5)Faculty of Pharmacy, The University of Sydney, Sydney, Australia.
(6)Pharmacy, School of Medicine and Pharmacology, The University of Western
Australia, Perth, Australia.
BACKGROUND: Research has shown that the current practice of pharmacy staff when
providing self-medication consultations in Indonesia is suboptimal. To improve
the performance of pharmacy staff when providing self-medication consultations in
community pharmacies, the factors that influence current practice need to be
understood. The aim of this study is to identify the factors that influence
current practice of pharmacy staff when handling self-medication consultations in
Eastern Indonesian community pharmacies.
METHODS: Fifteen in-depth interviews were conducted with pharmacists, pharmacy
technicians, pharmacy owners, and counter attendants. Thematic analysis was used
to generate findings.
RESULTS: The current practice of pharmacy staff when handling self-medication
consultations is directly influenced by the professionalism of pharmacy staff and
patient responses to the consultations. These factors are in turn affected by the
organisational context of the pharmacy and the external pharmacy environment. The
organisational context of the pharmacy includes staffing, staff affordability,
and the availability of time and facilities in which to provide consultations.
The external pharmacy environment includes the number of trained pharmacy staff
in the research setting, the relevance of pharmacy education to the needs of
pharmacy practice, the support offered by the Indonesian Pharmacists Association,
a competitive business environment, and the policy environment.
CONCLUSION: Complex and inter-related factors influence the current practice of
pharmacy staff when providing self-medication consultations in community
pharmacies in this research setting. Multiple strategies will be required to
improve consultation practices.
DOI: 10.1186/s12913-016-1425-3
PMCID: PMC4866032
PMID: 27178346 [Indexed for MEDLINE]
Topical ear drop self-medication practice among the Ear, Nose, and Throat
patients in Ido Ekiti, Nigeria: A cross - sectional study.
Olajide TG(1), Aremu KS(1), Esan OT(1), Dosunmu AO(1), Raji MM(1).
Author information:
(1)Department of Ear, Nose and Throat Surgery, Federal Teaching Hospital
Ido-Ekiti, Ekiti State, / Afe Babalola University Ado Ekiti (ABUAD), Nigeria.
Publisher: Contexte: L'automédication est une habitude courante dans notre pays;
Nigéria, en particulier chez les patients présentant des troubles
oto-rhino-laryngologiques. Les médicaments pris à tort peuvent avoir des
conséquences désastreuses pour l'individu, comme masquer des maladies en
développement et causer de nombreuses autres effets indésirables. Le but de cette
étude était de déterminer la prévalence et d'analyser les pratiques
d'automédication les participants à la clinique de l'oreille, du nez et de la
gorge de l'hôpital fédéral d'enseignement Ido Ekiti, au Nigeria. Conception et
Méthodologie: 6 mois étude transversale en milieu hospitalier a été menée auprès
de patients qui ont été vus dans l'établissement Oreille, Nez et Gorge de
l'Enseignement Fédéral Hôpital, Ido Ekiti de juillet à décembre 2016 pour
déterminer les pratiques d'automédication topique des gouttes auriculaires. Un
questionnaire semi-structuré prétesté a été utilisé pour obtenir des informations
auprès des répondants. Résultats: Un total de 162 répondants sur 493 patients vus
au cours de l'étude avaient problèmes otologiques. Dont 107 (66%) répondants se
sont engagés dans l'automédication avec des gouttes auriculaires topiques. Leur
âge variait entre 2 et 83 ans avec un âge moyen de 36,6 ± 19,1 ans. Il y avait 75
hommes et 87 femmes. La principale raison de l'automédication était que leur les
troubles étaient mineurs dans environ 40,2% des cas et l'indication la plus
fréquente d'automédication était un blocage de l'oreille avec déficience auditive
(33,6%). Les pharmacies / pharmacies (42%) étaient les principales sources
d'information pour ceux qui se soignaient eux-mêmes. Le chloramphénicol et la
gentamycine médicaments importants qui ont été utilisés par les répondants.
Conclusion: La majorité des répondants à cette étude pratiquaient
l'automédication en utilisant différents gouttes auriculaires topiques. La
principale source d'information sur les gouttes auriculaires topiques utilisées
provenait des pharmacies / pharmacies. Il y a un besoin de l'éducation en matière
de santé publique pour sensibiliser les gens au danger de l'automédication et
pour promulguer ou appliquer la loi afin de réduire l'accès à des médicaments en
vente libre. Les soins de santé devraient être disponibles et évitables au niveau
des soins de santé primaires. Mots-clés: Automédication, Nigeria, pratique,
gouttes auriculaires topiques.
DOI: 10.4103/aam.aam_28_17
PMCID: PMC5875122
PMID: 29536960 [Indexed for MEDLINE]
Simon AK(1), Rao A(2), Rajesh G(2), Shenoy R(2), Pai MB(2).
Author information:
(1)Department of Public Health Dentistry, Vivekanandha Dental College for Women,
Elayampalayam, Tiruchengode, Tamil Nadu, India.
(2)Department of Public Health Dentistry, Manipal College of Dental Sciences,
Manipal University, Mangalore, Karnataka, India.
DOI: 10.4103/0253-7613.165195
PMCID: PMC4621674
PMID: 26600642 [Indexed for MEDLINE]
Revisiting the 'self-medication' hypothesis in light of the new data linking low
striatal dopamine to comorbid addictive behavior.
Author information:
(1)Department of Psychiatry and Institute of Medical Science, University of
Toronto, Humber River Hospital, 2175 Keele Street, Room 243A, Toronto, Ontario
M6M 3Z4, Canada.
(2)Department of Psychiatry, Oakville-Trafalgar Memorial Hospital, Oakville,
Canada.
Persons with schizophrenia are at a high risk, almost 4.6 times more likely, of
having drug abuse problems than persons without psychiatric illness. Among the
influential proposals to explain such a high comorbidity rate, the
'self-medication hypothesis' proposed that persons with schizophrenia take to
drugs in an effort to cope with the illness and medication side effects. In
support of the self-medication hypothesis, data from our earlier clinical study
confirmed the strong association between neuroleptic dysphoria and negative
subjective responses and comorbid drug abuse. Though dopamine has been
consistently suspected as one of the major culprits for the development of
neuroleptic dysphoria, it is only recently our neuroimaging studies correlated
the emergence of neuroleptic dysphoria to the low level of striatal dopamine
functioning. Similarly, more evidence has recently emerged linking low striatal
dopamine with the development of vulnerability for drug addictive states in
schizophrenia. The convergence of evidence from both the dysphoria and
comorbidity research, implicating the role of low striatal dopamine in both
conditions, has led us to propose that the person with schizophrenia who develops
dysphoria and comorbid addictive disorder is likely to be one and the same.
DOI: 10.1177/2045125315583820
PMCID: PMC4502591
PMID: 26199720
Author information:
(1)Department of Nursing, Alkan University College Goba, Addis Ababa, Ethiopia.
(2)Department of Health Education and Behavioral Science, College of Medicine and
Health Sciences, University of Gondar, Gondar, Ethiopia.
(3)Department of Epidemiology and Biostatistics, College of Medicine and Health
Sciences, University of Gondar, Gondar, Ethiopia.
(4)Department of Epidemiology and Biostatistics, College of Medicine and Health
Sciences, University of Gondar, Gondar, Ethiopia. mayenew15@gmail.com.
DOI: 10.1186/s13104-018-3821-8
PMCID: PMC6180449
PMID: 30305180 [Indexed for MEDLINE]
Shah SJ, Ahmad H, Rehan RB, Najeeb S, Mumtaz M, Jilani MH, Rabbani MS, Alam MZ,
Farooq S, Kadir MM(1).
Author information:
(1)Department of Community Health Sciences, Aga Khan University, Karachi,
Pakistan. masood.kadir@aku.edu.
BACKGROUND: The prevalence of self -medication with antibiotics is quite high in
developing countries as opposed to developed countries. Antibiotics are often
taken erroneously for certain ailments, without having the appropriate knowledge
of their use. This carries potential risks for the individual as well as the
community, in form of several side effects such as antibiotic resistance.
Therefore the prevalence of self-medicated antibiotics in developing countries
needs to be studied.
METHODS: A descriptive cross-sectional study was carried out at six different
non-medical universities of Karachi. 431 students were included in the study.
Data was collected using self-administered questionnaires and analyzed using SPSS
version 19.
RESULTS: 50.1% students reported having self-medicated themselves in the past
6 months and 205 (47.6%) reported self-medication with antibiotics. Amoxicillin
was the most self-prescribed antibiotic (41.4%). Awareness of the adverse effects
of antibiotics was demonstrated by 77.3% of the students and sleep disturbance
was the most commonly known (46.5%) side effect. 63.1% denied having any
knowledge about antibiotic resistance and only 19.9% correctly knew that
indiscriminate use of antibiotics can lead to increased antibiotic resistance.
CONCLUSION: The prevalence of self-medication with antibiotics among the
non-medical university students was high despite the awareness of adverse
effects. Antibiotic resistance was a relatively unknown terminology.
DOI: 10.1186/2050-6511-15-74
PMCID: PMC4320599
PMID: 25534613 [Indexed for MEDLINE]
Author information:
(1)a Graduate Assistant, Division of Social and Behavioral Sciences, School of
Public Health , University of Memphis , Memphis , TN , USA.
(2)b Professor, Division of Social and Behavioral Sciences, School of Public
Health , University of Memphis , Memphis , TN , USA.
This article applies constructs from the Self-Medication Hypothesis and Social
Cognitive Theory to explain the development of substance use and psychological
distress after a disaster. A conceptual model is proposed, which employs a
sequential mediation model, identifying perceived coping self-efficacy,
psychological distress, and self-medication as pathways to substance use after a
disaster. Disaster exposure decreases perceived coping self-efficacy, which, in
turn, increases psychological distress and subsequently increases perceptions of
self-medication in vulnerable individuals. These mechanisms lead to an increase
in postdisaster substance use. Last, recommendations are offered to encourage
disaster researchers to test more complex models in studies on postdisaster
psychological distress and substance use.
DOI: 10.1080/02791072.2017.1397304
PMCID: PMC6101235
PMID: 29125424
Tripathy R(1), Pattnaik KP(2), Dehury S(3), Patro S(4), Mohanty P(3), Sahoo
SS(2), Mohanty S(3).
Author information:
(1)Department of Pharmacology, Kalinga Institute of Medical Sciences,
Bhubaneswar, Odisha, India.
(2)ADR Monitoring Centre, Department of Pharmacology, Cuttack, Odisha, India.
(3)Department of Pharmacology and Dermatology, SCB Medical College, Cuttack,
Odisha, India.
(4)Department of Dermatology, MKCG Medical College, Berhampur, Odisha, India.
DOI: 10.4103/ijp.IJP_760_16
PMCID: PMC6234708
PMID: 30505055 [Indexed for MEDLINE]
111. Ger Med Sci. 2015 Jul 9;13:Doc10. doi: 10.3205/000214. eCollection 2015.
Author information:
(1)Drug Regulatory Affairs, Rheinische Friedrich-Wilhelm-University, Bonn,
Germany.
(2)Committee of Research into Natural Medicines, Munich, Germany.
Media play an important role in the reception of health risks; thus, media
competence is important for enhancing the risk competence of patients and
consumers. In addition to life-long health education, risk competence
particularly requires careful handling of health information because, at present,
the key problem is not the lack of sufficient information on health topics but
the quality of such information. Patients and consumers of health procedures and
health products also require information which relates to their daily life and
matches their life style.
Publisher: Medien spielen bei der Rezeption von gesundheitlichen Risiken eine
wichtige Rolle. Zur Stärkung der Risikokompetenz von Patienten und Verbrauchern
gehört deshalb eine Medienkompetenz. Sie erfordert neben einer lebenslangen
Gesundheitsbildung besonders einen differenzierten Umgang mit
Gesundheitsinformationen, weil nicht die Informationsmenge über gesundheitliche
Themen derzeit ein Problem darstellt, sondern deren Qualität. Patienten bzw.
Anwender gesundheitlicher Verfahren und Produkte brauchen außerdem Informationen,
die sich auf ihren Alltag beziehen bzw. ihren Lebensstil treffen.
DOI: 10.3205/000214
PMCID: PMC4507062
PMID: 26195923 [Indexed for MEDLINE]
Author information:
(1)Geographic Data Science Lab, Department of Geography & Planning, University of
Liverpool, Liverpool, United Kingdom.
DOI: 10.1371/journal.pone.0207523
PMCID: PMC6242371
PMID: 30452481 [Indexed for MEDLINE]
Author information:
(1)Prof. M. Iqbal Afridi, FCPS, FRCP. Head, Dept. of Psychiatry & Behavioural
Sciences, Head, Dept. of Neurology, Secretary, Faculty of Psychiatry, College of
Physicians & Surgeons, Pakistan. Jinnah Post Graduate Medical Centre (JPMC),
Karachi, Pakistan.
(2)Dr. Ghulam Rasool, MBBS. Postgraduate FCPS-II Trainee, Dept. of Psychiatry &
Behavioural Sciences, Jinnah Post Graduate Medical Centre (JPMC), Karachi,
Pakistan.
(3)Dr. Rabia Tabassum, MBBS.
(4)Dr. Marriam Shaheen, MBBS. Dow University of Health Sciences, Karachi,
Pakistan.
(5)Dr. Siddiqullah, MBBS. Dow University of Health Sciences, Karachi, Pakistan.
(6)Dr. M. Shujauddin, MBBS. Dow University of Health Sciences, Karachi, Pakistan.
DOI: 10.12669/pjms.315.8216
PMCID: PMC4641291
PMID: 26649022
Self medication practice and associated factors among students of Asmara College
of Health Sciences, Eritrea: a cross sectional study.
DOI: 10.1186/s40545-019-0165-2
PMCID: PMC6381702
PMID: 30828458
Conflict of interest statement: The study was approved by the research clearance
committee of the Research department of the Ministry of Health, Eritrea. The
participants of the study were informed on the aim and objectives of the study
and written informed consents were obtained from all the participants prior to
data collection. Participants had the right to withdraw from participating in the
study anytime during data collection and confidentiality of the data was assured
by collecting information anonymously and not including personal identifiers.Not
applicable.The authors declare that they have no competing interests.Springer
Nature remains neutral with regard to jurisdictional claims in published maps and
institutional affiliations.
Author information:
(1)Department of Pharmacology, Narayan Medical College and Hospital, Sasaram,
Bihar, India.
(2)Department of Physiology, Narayan Medical College and Hospital, Sasaram,
Bihar, India.
(3)Department of Community Medicine, Narayan Medical College and Hospital,
Sasaram, Bihar, India.
DOI: 10.4103/0976-500X.195903
PMCID: PMC5242032
PMID: 28163540
116. Int J High Risk Behav Addict. 2015 Jun 20;4(2):e26155. doi:
10.5812/ijhrba.4(2)2015.26155. eCollection 2015 Jun.
Metanat M(1).
Author information:
(1)Infectious Diseases and Tropical Medicine Research Center, Boo-Ali Hospital,
Zahedan University of Medical Sciences, Zahedan, IR Iran.
DOI: 10.5812/ijhrba.4(2)2015.26155
PMCID: PMC4464574
PMID: 26097839
Author information:
(1)Department of Health Education and Promotion, School of Health, Isfahan
University of Medical Sciences, Isfahan, Iran.
118. Drug Discov Ther. 2017 Mar 22;11(1):35-40. doi: 10.5582/ddt.2016.01075. Epub
2017
Feb 8.
Author information:
(1)Department of Pharmaceutical Sciences, Meiji Pharmaceutical University.
This study was conducted in order to establish a health management method for the
elderly in a community through follow-ups of bone mineral density (BMD)
measurement results over a 1-year period based on BMD measurements performed by
pharmacists and a guidance program. Regarding BMD measurement results, the
percent young adult mean (%YAM: mean BMD in healthy persons of the same sex aged
between 51 and 82 years old) significantly increased in Period I, during which
the intervention by pharmacists was performed (6 months after the start of
measurements), but significantly decreased in Period II, during which this
intervention was not performed (between 7 and 12 months after the start of
measurements). Based on these results, lifestyle improvements were effective in
Period I regardless of sex or age; however, it may be important to maintain an
improved diet and subject motivation in the future. The results of this study
suggest that community pharmacists play an important role in community medicine
through positive intervention for local residents' health support.
DOI: 10.5582/ddt.2016.01075
PMID: 28179604 [Indexed for MEDLINE]
Factors associated with self medication practice among pregnant mothers attending
antenatal care at governmental health centers in Bahir Dar city administration,
Northwest Ethiopia, a cross sectional study.
Author information:
(1)Bahir Dar University, College of Medicine and Health Sciences, Bahir Dar,
Ethiopia.
(2)Ethiopian Red Cross Society Essential drug Program, Bahir Dar, Ethiopian.
INTRODUCTION: Studies in different parts of the world indicate that there is high
level use of self medication among pregnant women. But there are no scientific
evidences on it and factors associated with it in Bahir Dar city administration.
The aim of this study was therefore to assess level of self medication and
identify factors associated with it among pregnant women attending ANC service at
governmental health centers in Bahir Dar city administration.
METHODS: Institution based cross-sectional study was conducted from June 20-July
10, 2013. Data were collected using structured questionnaire and analyzed using
SPSS version 16.0. Back ward logistic regression model was used to assess level
of association with self medication practice.
RESULTS: A total of 510 pregnant women were included in the study. Of these,
25.1% reported self-medication during the current pregnancy. Self medication
during pregnancy was significantly associated with gravida (AOR = 2.1, 95% CI:
1.3-3.4), maternal illness on the date of interview (AOR = 4.8, 95% CI: 2.9-8.0)
and location of health facility (AOR = 4.6; 95% CI: 2.9-7.4).
CONCLUSION: A considerable proportion of pregnant women practiced self-medication
during their pregnancy with modern medications or traditional herbs. Mothers who
were multi gravida, who had maternal illness on the date of interview and who
were attending antenatal care were more likely to practice self medication.
DOI: 10.11604/pamj.2015.20.276.4243
PMCID: PMC4483357
PMID: 26161199 [Indexed for MEDLINE]
Author information:
(1)Faculty of Medicine, University of Niš, Zorana Đinđića 81, 18000 Niš, Serbia.
(2)Clinic for Mental Health, Clinical Center Niš, 18000 Niš, Serbia.
(3)Department of Physiology, Faculty of Medicine, University of Niš, Zorana
Đinđića 81, 18000 Niš, Serbia.
(4)Department of Chemistry, Faculty of Science and Mathematics, University of
Niš, Višegradska 33, 18000 Niš, Serbia.
The aim of this study was to evaluate the usage prevalence of herbal products
(HP) and to ascertain the identity, mode and adverse effects of plant taxa used
in self-medication practice for anxiety, depression and insomnia in patients with
non-psychotic disorders originating from southeastern Serbia. Also, we compared
HP users and non-users on the variables of socio-demographic characteristics,
information source and origin of HP. The study was done by a face-to-face
interview with a trained psychiatrist using a structured questionnaire
administered to 136 adult patients suffering from non-psychotic mental disorders.
A typical herbal-product user among non-psychotic psychiatric patients from
southeastern Serbia is a middle-aged married woman, with a secondary level of
education, unemployed and living in an urban area. Non-psychotic psychiatric
patients, although not living predominantly in rural areas, were familiar with a
variety of ethno-medicines and were often using HP primarily without the
consultation of their psychiatrists/physicians. HP stated to be most frequently
used for psychiatry-related symptoms included: Melissa officinalis,
Mentha × piperita, Hypericum perforatum and Valeriana officinalis. The
interviewees rarely stated adverse reactions related to the HP usage; however,
this should not be generalized, since HP are known to vary in the content of
their adverse reaction-causing constituents.
DOI: 10.1016/j.jsps.2017.02.002
PMCID: PMC5605899
PMID: 28951674
121. J Adolesc Health. 2017 Apr;60(4):380-387. doi:
10.1016/j.jadohealth.2016.09.019.
Epub 2016 Nov 30.
Author information:
(1)Psychology Department, Université de Montréal, Montréal, Québec, Canada.
(2)School of Psychoeducation, Université de Montréal, Montréal, Québec, Canada.
Electronic address: natalie.castellanos.ryan@umontreal.ca.
(3)School of Psychoeducation, Université de Montréal, Montréal, Québec, Canada.
(4)Department of Psychiatry, McGill University, and Douglas Mental Health
University Institute, Montréal, Québec, Canada.
(5)School of Psychoeducation, Université de Montréal, Montréal, Québec, Canada;
Centre de recherche du CHU Ste-Justine, Montréal, Québec, Canada.
(6)Psychology Department, Université Laval, Québec, Québec, Canada.
(7)Centre de recherche du CHU Ste-Justine, Montréal, Québec, Canada; Department
of Pediatrics and Psychology, Université de Montréal, Québec, Canada; Institute
of Genetic, Neurobiological, Social Foundations of Child Development, Tomsk State
University, Russian Federation; School of Public Health and Population Science,
University College, Dublin, Ireland.
(8)Centre de recherche du CHU Ste-Justine, Montréal, Québec, Canada; Department
of Psychiatry, Université de Montréal, Montréal, Québec, Canada.
Comment in
J Adolesc Health. 2017 Apr;60(4):357.
Author information:
(1)Department of Social Epidemiology, Institut Pierre Louis d'Epidémiologie et de
Santé Publique (UMRS 1136), INSERM, Sorbonne Université, Paris, France.
(2)Research team on social inequalities, Centre Maurice Halbwachs (UMR 8097),
CNRS, EHESS, ENS, Paris, France.
(3)Department of General Practice, Sorbonne Université, Paris, France.
DOI: 10.1371/journal.pone.0208632
PMCID: PMC6296538
PMID: 30557334 [Indexed for MEDLINE]
Author information:
(1)Assistant Professor, Department of Pharmacology, Manipal College of Medical
Sciences (MCOMS) , Deep height, Pokhara, Nepal .
(2)Professor, Department of Pharmacology, Xavier University School of Medicine ,
Oranjestad, Aruba, Kingdom of the Netherlands .
(3)Assistant Professor, Department of Anatomy, Manipal College of Medical
Sciences (MCOMS) , Deep height, Pokhara, Nepal .
(4)Professor and Head, Department of Pharmacology, Manipal College of Medical
Sciences (MCOMS) , Deep height, Pokhara, Nepal .
DOI: 10.7860/JCDR/2015/16553.6988
PMCID: PMC4717826
PMID: 26816912
Author information:
(1)Department of Biochemistry, Faculty of Basic Medical Sciences, Libyan
International Medical University, Benghazi, Libya.
DOI: 10.4103/0975-7406.154432
PMCID: PMC4399008
PMID: 25883514
125. Integr Pharm Res Pract. 2015 Jun 24;4:57-65. doi: 10.2147/IPRP.S70403.
eCollection 2015.
Rutter P(1).
Author information:
(1)School of Pharmacy, University of Wolverhampton, Wolverhampton, UK.
This review highlights the growing prominence of self-care and explores the
contribution of community pharmacy. Firstly, background to self-care is
discussed, followed by placing self-care in context with regard to the general
public and accessing community pharmacy. From this perspective the contribution
community pharmacy currently makes is assessed, paying particular attention to
the factors that negatively impact on the ability of community pharmacy to
facilitate self-care.
DOI: 10.2147/IPRP.S70403
PMCID: PMC5741028
PMID: 29354520
126. Addiction. 2016 Jul;111(7):1160-74. doi: 10.1111/add.13324. Epub 2016 Mar 18.
Author information:
(1)Center on Drug and Alcohol Research, Department of Behavioral Science,
University of Kentucky College of Medicine, Lexington, KY, USA.
(2)Department of Epidemiology, University of Kentucky College of Public Health,
Lexington, KY, USA.
(3)Department of Biostatistics, University of Kentucky College of Public Health,
Lexington, KY, USA.
(4)Department of Pharmacology, University of Kentucky College of Medicine,
Lexington, KY, USA.
(5)Department of Pharmaceutical Sciences, University of Kentucky College of
Pharmacy, Lexington, KY, USA.
Comment in
Addiction. 2016 Jul;111(7):1175-6.
BACKGROUND AND AIMS: Since its market release, gabapentin has been presumed to
have no abuse potential and subsequently has been prescribed widely off-label,
despite increasing reports of gabapentin misuse. This review estimates and
describes the prevalence and effects of, motivations behind and risk factors for
gabapentin misuse, abuse and diversion.
METHODS: Databases were searched for peer-reviewed papers demonstrating
gabapentin misuse, characterized by taking a larger dosage than prescribed or
taking gabapentin without a prescription, and diversion. All types of studies
were considered; grey literature was excluded. Thirty-three papers met inclusion
criteria, consisting of 23 case studies and 11 epidemiological reports. Published
reports came from the United States, the United Kingdom, Germany, Finland, India,
South Africa and France, and two analyzed websites not specific to a particular
country.
RESULTS: Prevalence of gabapentin misuse in the general population was reported
to be 1%, 40-65% among individuals with prescriptions and between 15 and 22%
within populations of people who abuse opioids. An array of subjective
experiences reminiscent of opioids, benzodiazepines and psychedelics were
reported over a range of doses, including those within clinical recommendations.
Gabapentin was misused primarily for recreational purposes, self-medication or
intentional self-harm and was misused alone or in combination with other
substances, especially opioids, benzodiazepines and/or alcohol. Individuals with
histories of drug abuse were most often involved in its misuse.
CONCLUSIONS: Epidemiological and case report evidence suggests that the
anti-epileptic and analgesic medication gabapentin is being misused
internationally, with substance abuse populations at special risk for
misuse/abuse.
DOI: 10.1111/add.13324
PMCID: PMC5573873
PMID: 27265421 [Indexed for MEDLINE]
127. BMC Nurs. 2018 Aug 3;17:35. doi: 10.1186/s12912-018-0302-2. eCollection 2018.
Soroush A(1), Abdi A(2), Andayeshgar B(1), Vahdat A(1), Khatony A(3)(4).
Author information:
(1)1Clinical Research Development Center of Imam Reza Hospital, Kermanshah
University of Medical Sciences, Kermanshah, Iran.
(2)2Students Research Committee, School of Nursing and Midwifery, Kermanshah
University of Medical Sciences, Kermanshah, Iran.
(3)3Social Development and Health Promotion Research Center, Kermanshah
University of Medical Sciences, Kermanshah, Iran.
(4)Nursing Department, School of Nursing and Midwifery, Doolat Abaad, Kermanshah,
Iran.
DOI: 10.1186/s12912-018-0302-2
PMCID: PMC6091042
PMID: 30123087
Mansouri A(1), Sarayani A(1), Ashouri A(2), Sherafatmand M(3), Hadjibabaie M(4),
Gholami K(4).
Author information:
(1)Research Center for Rational Use of Drugs, Tehran University of Medical
Sciences, Tehran, Iran.
(2)Research Center for Rational Use of Drugs, Tehran University of Medical
Sciences, Tehran, Iran; Department of Epidemiology and Biostatistics, School Of
Public Health, Tehran University of Medical Sciences, Tehran, Iran.
(3)Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
(4)Research Center for Rational Use of Drugs, Tehran University of Medical
Sciences, Tehran, Iran; Faculty of Pharmacy, Tehran University of Medical
Sciences, Tehran, Iran.
DOI: 10.1371/journal.pone.0125093
PMCID: PMC4416799
PMID: 25932634 [Indexed for MEDLINE]
Author information:
(1)Public Health Emergency Management, Ethiopian Somali Regional Health Bureau,
Jigjiga, Ethiopia.
(2)Departments of Environmental Health Science, Haramaya University, Harar,
Ethiopia.
(3)School of Public Health, Haramaya University, Harar, Ethiopia.
DOI: 10.1371/journal.pone.0218772
PMCID: PMC6599130
PMID: 31251745
Tan R(1), Cvetkovski B(2), Kritikos V(3), Yan K(4), Price D(5), Smith P(6),
Bosnic-Anticevich S(7).
Author information:
(1)Quality Use of Respiratory Medicines Group, Woolcock Institute of Medical
Research, University of Sydney. Sydney (Australia). stan6464@uni.sydney.edu.au.
(2)Quality Use of Respiratory Medicines Group, Woolcock Institute of Medical
Research, University of Sydney. Sydney, NSW (Australia).
biljana.cvetkovski@sydney.edu.au.
(3)Clinical Researcher Pharmacist. Quality Use of Respiratory Medicines Group,
Woolcock Institute of Medical Research, University of Sydney; & Department of
Respiratory Medicine, Royal Prince Alfred Hospital. Sydney, NSW (Australia).
vicky.kritikos@sydney.edu.au.
(4)Department of Respiratory Medicine, Royal Prince Alfred Hospital. Sydney, NSW
(Australia). kwokyan@yansydney.com.
(5)Academic Primary Care, University of Aberdeen, Aberdeen (United Kingdom).
dprice@opri.sg.
(6)Institution: Clinical Medicine, Griffith University. Southport, QLD
(Australia). pksm@mac.com.
(7)Professor and Principal Research Fellow. Quality Use of Respiratory Medicines
Group, Woolcock Institute of Medical Research, University of Sydney; & Sydney
Local Health District, Sydney, NSW (Australia).
sinthia.bosnic-anticevich@sydney.edu.au.
DOI: 10.18549/PharmPract.2018.03.1332
PMCID: PMC6207357
PMID: 30416632
Author information:
(1)The University of Texas MD Anderson Cancer Center, Michale E Keeling Center
for Comparative Medicine and Research, 650 Cool Water Drive, Bastrop, TX 78602,
USA.
(2)Department of Experimental Medicine, University of Copenhagen, Faculty of
Health Sciences and University Hospital, 3B Blegdamsvej, DK-2200 Copenhagen,
Denmark.
DOI: 10.7120/09627286.27.4.327
PMCID: PMC6594570
PMID: 31244511
Shafie M(1), Eyasu M(1), Muzeyin K(2), Worku Y(3), Martín-Aragón S(4).
Author information:
(1)Saint Paul's Hospital Millennium Medical College, Department of Pharmacology,
Addis Ababa, Ethiopia.
(2)Saint Paul's Hospital Millennium Medical College, Department of Nursing, Addis
Ababa, Ethiopia.
(3)Saint Paul's Hospital Millennium Medical College, Department of Public Health,
Addis Ababa, Ethiopia.
(4)Complutense University of Madrid, School of Pharmacy, Department of
Pharmacology, Madrid, Spain.
BACKGROUND AND AIM: Self-medication (SM) is one part of self-care which is known
to contribute to primary health care. If practiced appropriately, it has major
benefits for the consumers such as self-reliance and decreased expense. However,
inappropriate practice can have potential dangers such as incorrect
self-diagnosis, dangerous drug-drug interactions, incorrect manner of
administration, incorrect dosage, incorrect choice of therapy, masking of a
severe disease, and/or risk of dependence and abuse. The main objective of this
study was to assess the prevalence and determinants of the self-medication
practice (SMP) in Addis Ababa.
METHODOLOGY: A community based cross-sectional study was conducted among selected
households in Addis Ababa from April 2016 to May 2016, with a recall period of
two months before its conduction. Trained data collectors were employed to
collect the data from the 604 sampled participants using pre-tested and validated
questionnaires.
RESULT: Among the 604 participants involved in this study, 422 (69.9%) were
female and 182 (30.1%) were male and there was a mean age of 41.04 (± 13.45)
years. The prevalence of SM in this study was 75.5%. The three most frequently
reported ailments were headache 117 (25.7%), abdominal pain 59 (12.9%) and cough
54 (11.8%). The two main reasons for SM were mildness of illness 216 (47.4%) and
previous knowledge about the drug 106 (23.2%). The two most frequently consumed
medications were paracetamol 92 (20.2%) and traditional remedies 73 (16.0%),
while drug retail outlets 319 (83.3%) were the main source of drugs. The two most
frequently reported source of drug information were health professionals 174
(45.4%) and experience from previous treatment 82 (21.4%). Moreover, there were
statistically significant differences among respondents who reported practicing
SM based on income and knowledge about appropriate SMP.
CONCLUSION AND RECOMMENDATION: Self-medication was practiced with a range of
drugs from the conventional paracetamol and NSAIDs to antimicrobials. Being that
the practice of SM is inevitable, health authorities and professionals are highly
demanded to educate the public not only on the advantages and disadvantages of SM
but on its proper use.
DOI: 10.1371/journal.pone.0194122
PMCID: PMC5868796
PMID: 29579074 [Indexed for MEDLINE]
133. Daru. 2019 Jun;27(1):83-89. doi: 10.1007/s40199-019-00244-9. Epub 2019 Jan 24.
Author information:
(1)School of Nursing, Fasa University of Medical Sciences, Fasa, Iran.
(2)Department of Nursing, Faculty of Medicine, Sari Branch, Islamic Azad
University, Sari, Iran.
(3)Department of Medical-Surgical Nursing, School of Nursing and Midwifery,
Shiraz University of Medical Sciences, Shiraz, Iran. majidnajafi5@yahoo.com.
DOI: 10.1007/s40199-019-00244-9
PMCID: PMC6593005 [Available on 2020-01-24]
PMID: 30680607
Author information:
(1)Department of Pharmacy, College of Medical and Business, Addis Ababa,
Ethiopia.
(2)Department of Health Systems and Policy, Institute of Public Health, College
of Medicine and Health Sciences, University of Gondar, P.O.Box 196, Gondar,
Ethiopia.
(3)Department of Health Systems and Policy, Institute of Public Health, College
of Medicine and Health Sciences, University of Gondar, P.O.Box 196, Gondar,
Ethiopia. debieayal@gmail.com.
DOI: 10.1186/s13104-019-4195-2
PMCID: PMC6425615
PMID: 30890186 [Indexed for MEDLINE]
135. Ann Med Health Sci Res. 2014 Nov;4(6):884-8. doi: 10.4103/2141-9248.144896.
Author information:
(1)Department of Dental Surgery, University of Calabar Teaching Hospital,
Calabar, Nigeria.
(2)Department of Oral and Maxillofacial Surgery, University of Benin Teaching
Hospital, Benin-City, Nigeria.
DOI: 10.4103/2141-9248.144896
PMCID: PMC4250986
PMID: 25506481
Author information:
(1)Department of Dermatology, Command Hospital (EC), Kolkata, West Bengal, India.
E-mail: shekharadvait@gmail.com.
(2)Department of Pathology, Command Hospital (EC), Kolkata, West Bengal, India.
DOI: 10.4103/0019-5154.182431
PMCID: PMC4885198
PMID: 27293266
Begashaw Bekele B(1)(2), Tesema Berkesa S(3), Tefera E(3), Kumalo A(4).
Author information:
(1)Department of Public Health, College of Health Sciences, Mizan Tepi
University, Mizan Aman, Ethiopia.
(2)Institute of Public Health, College of Medicine and Health Sciences,
University of Gondar, Gondar, Ethiopia.
(3)Department of Pharmacy, Jimma University, Jimma, Ethiopia.
(4)Medical Laboratory Sciences Department, College of Medicine and Health
Sciences, Wolaita Sodo University, Sodo, Ethiopia.
DOI: 10.1155/2018/1749137
PMCID: PMC5838479
PMID: 29675282
138. Biomed Res Int. 2016;2016:3916874. doi: 10.1155/2016/3916874. Epub 2016 Jan 5.
Al Rasheed A(1), Yagoub U(2), Alkhashan H(1), Abdelhay O(2), Alawwad A(1), Al
Aboud A(3), Al Battal S(4).
Author information:
(1)Department of Family and Community Medicine, Prince Sultan Military Medical
City, P.O. Box 7897, Riyadh 11159, Saudi Arabia.
(2)Research Unit, Family and Community Medicine Department, Prince Sultan
Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi Arabia.
(3)Al Wazarat Health Center, Prince Sultan Military Medical City, P.O. Box 7897,
Riyadh 11159, Saudi Arabia.
(4)Training and Research Unit of Family and Community Medicine Department, Prince
Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi Arabia.
DOI: 10.1155/2016/3916874
PMCID: PMC4736398
PMID: 26881218 [Indexed for MEDLINE]
139. Rev Bras Epidemiol. 2019 Feb 4;21Suppl 02(Suppl 02):e180007. doi:
10.1590/1980-549720180007.supl.2.
Self-medication practice trend among the Brazilian elderly between 2006 and 2010:
SABE Study.
Author information:
(1)Departamento de Enfermagem Médico-Cirúrgica, Escola de Enfermagem,
Universidade de São Paulo - São Paulo (SP), Brasil.
(2)Instituto do Coração, Universidade de São Paulo - São Paulo (SP), Brasil.
(3)Departamento de Prática de Saúde Pública, Faculdade de Saúde Pública,
Universidade de São Paulo - São Paulo (SP), Brasil.
(4)Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São
Paulo - São Paulo (SP), Brasil.
Susheela F(1), Goruntla N(1), Bhupalam PK(2), Veerabhadrappa KV(3), Sahithi B(1),
Ishrar SMG(1).
Author information:
(1)Department of Pharmacy Practice, Raghavendra Institute of Pharmaceutical
Education and Research, Anantapur, Andhra Pradesh, India.
(2)Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education
and Research, Anantapur, Andhra Pradesh, India.
(3)Department of Pharmacognosy, Raghavendra Institute of Pharmaceutical Education
and Research, Anantapur, Andhra Pradesh, India.
DOI: 10.4103/jehp.jehp_175_17
PMCID: PMC6088819
PMID: 30159342
141. BMC Health Serv Res. 2015 Jan 22;15:8. doi: 10.1186/s12913-014-0670-6.
Brata C(1)(2), Marjadi B(3), Schneider CR(4), Murray K(5), Clifford RM(6).
Author information:
(1)Pharmacy, School of Medicine and Pharmacology, The University of Western
Australia, Perth, Australia. 20805921@student.uwa.edu.au.
(2)Centre of Medicine Information and Pharmaceutical Care, The University of
Surabaya, Surabaya, Indonesia. 20805921@student.uwa.edu.au.
(3)School of Medicine, The University of Western Sydney, Sydney, Australia.
B.Marjadi@uws.edu.au.
(4)Faculty of Pharmacy, The University of Sydney, Sydney, Australia.
carl.schneider@sydney.edu.au.
(5)Centre for Applied Statistics, The University of Western Australia, Perth,
Australia. kevin.murray@uwa.edu.au.
(6)Pharmacy, School of Medicine and Pharmacology, The University of Western
Australia, Perth, Australia. rhonda.clifford@uwa.edu.au.
DOI: 10.1186/s12913-014-0670-6
PMCID: PMC4312435
PMID: 25608555 [Indexed for MEDLINE]
Author information:
(1)The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
(2)The Islamia University of Bahawalpur, Punjab-Pakistan, Bahawalpur, Pakistan.
DOI: 10.1016/j.jval.2014.08.1595
PMID: 27201598
Odell AP(1), Reynolds GL, Fisher DG, Huckabay LM, Pedersen WC, Xandre P, Miočević
M.
Author information:
(1)*School of Nursing, †Center for Behavioral Research and Services, and
‡Department of Psychology, California State University, Long Beach, CA; and
§Department of Psychology, Arizona State University, Tempe, AZ.
This study compares adults with and without attention deficit hyperactivity
disorder (ADHD) on measures of direct and displaced aggression and illicit drug
use. Three hundred ninety-six adults were administered the Wender Utah Rating
Scale, the Risk Behavior Assessment, the Aggression Questionnaire (AQ), and the
Displaced Aggression Questionnaire (DAQ). Those with ADHD were higher on all
scales of the AQ and DAQ, were younger at first use of amphetamines, and were
more likely to have ever used crack and amphetamines. A Structural Equation Model
found a significant interaction in that for those with medium and high levels of
verbal aggression, ADHD predicts crack and amphetamine. Follow-up logistic
regression models suggest that blacks self-medicate with crack and whites and
Hispanics self-medicate with amphetamine when they have ADHD and verbal
aggression.
DOI: 10.1097/NMD.0000000000000668
PMCID: PMC5439354
PMID: 28230564 [Indexed for MEDLINE]
Shamsudeen SM(1), Priya RS(2), Sujatha G(1), Muruganandhan J(1), Manikandan K(3).
Author information:
(1)Department of Oral Pathology, Sri Venkateswara Dental College and Hospital,
Chennai, Tamil Nadu, India.
(2)Department of Periodontia, Sri Venkateswara Dental College and Hospital,
Chennai, Tamil Nadu, India.
(3)Department of Public Health Dentistry, Sri Venkateswara Dental College and
Hospital, Chennai, Tamil Nadu, India.
DOI: 10.4103/jehp.jehp_143_17
PMCID: PMC5963215
PMID: 29922695
Author information:
(1)Psychiatry Service, VA Connecticut Healthcare System, 950 Campbell Avenue,
West Haven, CT 06516, USA; Department of Psychiatry, Yale University School of
Medicine, New Haven, CT, USA.
(2)Psychiatry Service, VA Connecticut Healthcare System, 950 Campbell Avenue,
West Haven, CT 06516, USA; Department of Psychiatry, Yale University School of
Medicine, New Haven, CT, USA; Abraham Ribicoff Research Facilities, Connecticut
Mental Health Center, 34 Park Street, New Haven, CT 06519, USA.
(3)Department of Psychiatry, Yale University School of Medicine, New Haven, CT,
USA; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, 34
Park Street, New Haven, CT 06519, USA.
(4)Psychiatry Service, VA Connecticut Healthcare System, 950 Campbell Avenue,
West Haven, CT 06516, USA; Department of Psychiatry, Yale University School of
Medicine, New Haven, CT, USA; Abraham Ribicoff Research Facilities, Connecticut
Mental Health Center, 34 Park Street, New Haven, CT 06519, USA. Electronic
address: deepak.dsouza@yale.edu.
DOI: 10.1016/j.schres.2017.03.047
PMCID: PMC5630481
PMID: 28392208 [Indexed for MEDLINE]
Self-medication for cough and the common cold: information needs of consumers.
BACKGROUND: Despite the high use of over-the-counter (OTC) cough and cold
medicines, little is known about Australia's cough and cold medicines information
needs. The aim of this study was to identify gaps in consumers' perceived
knowledge and concerns, to better target consumer medicines information and
improve quality use of medicines.
METHODS: We analysed cough-and-cold related enquiries from consumers who
contacted an Australian national medicine call centre between September 2002 and
June 2010.
RESULTS: Of 5503 cough and cold calls, female callers made up 86% of the calls
and 33% were related to children. Questions most frequently related to drug-drug
interactions (29%). An analysis of narratives over an 18-month period (248 calls)
revealed 20% of the calls concerned potentially clinically relevant interactions,
particularly those involving psychotropic agents.
DISCUSSION: The potential for interactions with cough and cold medicines
purchased OTC is recognised by consumers. Patient information should address
their concerns. Doctors should be aware of the common cough and cold interactions
and communicate likely clinical symptoms to patients when prescribing medication
to prevent potential harm.
Ateshim Y(1), Bereket B(2), Major F(2), Emun Y(2), Woldai B(2), Pasha I(2), Habte
E(3), Russom M(4).
Author information:
(1)School of Pharmacy, Asmara College of Health Sciences, Asmara, Eritrea.
yonatesh23@gmail.com.
(2)School of Pharmacy, Asmara College of Health Sciences, Asmara, Eritrea.
(3)Biostatistics and Epidemiology Unit, School of Public Health, Asmara College
of Health Sciences, Asmara, Eritrea.
(4)Eritrean Pharmacovigilance Centre, National Medicine and Food Administration,
Ministry of Health, Asmara, Eritrea.
DOI: 10.1186/s12889-019-7020-x
PMCID: PMC6558833
PMID: 31182071 [Indexed for MEDLINE]
Author information:
(1)Anthropology Centre for Conservation, Environment and Development, Oxford
Brookes University, Oxford, United Kingdom.
(2)Bulindi Chimpanzee and Community Project, Hoima, Uganda.
(3)Department of Infectious Disease Control, Faculty of Medicine, Oita
University, Hasama, Yufu, Oita, Japan.
(4)Department of Biology, Faculty of Medicine, Oita University, Hasama, Yufu,
Oita, Japan.
(5)Department of Psychology and Behavioral Neuroscience, Randolph-Macon College,
Ashland, Virginia, United States of America.
(6)Primate Research Institute, Kyoto University, Inuyama, Japan.
DOI: 10.1371/journal.pone.0180431
PMCID: PMC5503243
PMID: 28692673 [Indexed for MEDLINE]
Author information:
(1)Department of Pharmacology, School of Medicine, Shahroud University of Medical
Sciences, Shahroud, Islamic Republic of Iran.
(2)School of Medicine, Shiraz University of Medical Sciences, Shiraz, Islamic
Republic of Iran.
Publisher: التخزين المنزلي للدوية وممارسات التطبيب الذاتي في جنوب شرق جمهورية
رضا فوروتانإن التطبيب الذاتي والتخزين غير الملئم،إيران السلميةبهزاد فوروتان
وقد هدفت دراسة أجريت في جنوب شرق.للدوية في المنزل يشكلن مخاطر صحية محتملة
وإلى تقييم،جمهورية إيران السلمية إلى تحديد الماكن التي تحفظ بها السر أدويتها
تمت زيارة أسر من2010 ففي مسح مستعرض أجري عام.وتيرة التطبيب الذاتي ومحدددداته
فكانت.( وتم ملء استبيان شبه منظم500 = مناطق مختلفة من مدينة بيرجند )العدد
تلتها أدوية علج نزلت البرد،المسكنات أكثر الدوية التي تخزن في المنزل شيوعاا
وكانت الثلجة المكان الكثر شيوعا ا لتخزين الدوية.لدى البالغين والمضادات الحيوية
(50.6%). وذكرت أسر.وتب د رين أن معظم السر لم تطلع على النشرات المدرجة في العبوات
وكانت وتيرة إعادة استخدام المضادات،( أنها تمارس التطبيب الذاتي%53.6) كثيرة
وكان هناك تراببط كبير بين التطبيب الذاتي.الحيوية الموصوفة من قبل الطباء عالية
لم يكن هناك ترابط مع السن والجنس والمهنة ونوع التأمين وكذلك.والمستوى التعليمي
وخلصت الدراسة إلى أن هناك حاجة إلى تحسين معرفة الجمهور ومعلوماتهم.الوضع العائلي
بشأن تخزين الدوية ومخاطر إعادة استخدام أدوية الوصفات الطبية.Publisher:
Conservation de médicaments à domicile et pratiques d'automédication dans le
sud-est de la République islamique d'Iran.L'automédication et la conservation
inappropriée de médicaments à domicile représentent des risques potentiels pour
la santé. La présente enquête transversale réalisée en 2010 dans le sud-est de la
République islamique d'Iran visait à déterminer où les ménages conservaient leurs
médicaments et à évaluer la fréquence de l'automédication et ses déterminants.
Des ménages dans différents quartiers de la ville de Birjand (n = 500) ont fait
l'objet d'une visite et ont rempli un questionnaire semi-structuré. Les
analgésiques étaient les médicaments les plus couramment conservés à domicile,
suivis par les médicaments contre le rhume chez l'adulte et les antibiotiques. Le
réfrigérateur était l'endroit le plus fréquent pour la conservation des
médicaments (50,6 %). La plupart des ménages ne consultaient pas les notices des
médicaments. De nombreux ménages (53,6 %) ont affirmé qu'ils pratiquaient
l'automédication, et la fréquence de réutilisation des antibiotiques prescrits
par un médecin était élevée. Il existait une forte association entre
l'automédication et le niveau d'études, contrairement à l'âge, au sexe, à la
situation matrimoniale, au métier et au type d'assurance. La population a besoin
d'accroître ses connaissances et son niveau d'information sur la conservation des
médicaments et sur les risques liés à la réutilisation des médicaments prescrits.
Al-Qahtani MA(1), Amin HS(1), Al-Qahtani AA(1), Alshahrani AM(1), Alghamdi HA(1),
Althwayee MS(2), Alzahrani AA(2).
Author information:
(1)Department of Family and Community Medicine, King Khalid University Hospital,
College of Medicine, King Saud University, Riyadh, Saudi Arabia.
(2)Department of Family and Community Medicine, Prince Sultan Military Medical
Center, Riyadh, Saudi Arabia.
Author information:
(1)Department of Biostatistics, Yale University , New Haven, CT , USA.
DOI: 10.3389/fpubh.2016.00069
PMCID: PMC4834428
PMID: 27148515
Hemmingsson E(1)(2).
Author information:
(1)The Swedish School of Sport and Health Sciences, Box 5626, 114 86, Stockholm,
Sweden. erik.hemmingsson@gih.se.
(2)Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
erik.hemmingsson@gih.se.
PURPOSE OF REVIEW: To explore the sequence and interaction of infancy and early
childhood risk factors, particularly relating to disturbances in the social
environment, and how the consequences of such exposures can promote weight gain
and obesity.
RECENT FINDINGS: This review will argue that socioeconomic adversity is a key
upstream catalyst that sets the stage for critical midstream risk factors such as
family strain and dysfunction, offspring insecurity, stress, emotional turmoil,
low self-esteem, and poor mental health. These midstream risk factors,
particularly stress and emotional turmoil, create a more or less perfect foil for
calorie-dense junk food self-medication and subtle addiction, to alleviate
uncomfortable psychological and emotional states. Disturbances in the social
environment during infancy and early childhood appear to play a critical role in
weight gain and obesity, through such mechanisms as insecurity, stress, and
emotional turmoil, eventually leading to junk food self-medication and subtle
addiction.
DOI: 10.1007/s13679-018-0310-2
PMCID: PMC5958160
PMID: 29704182 [Indexed for MEDLINE]
Author information:
(1)Pharm.D 5th Year student, College of Clinical Pharmacy, Imam Abdulrahman Bin
Faisal University, Dammam 31441, Saudi Arabia.
(2)Department of Pharmacy Practice, College of Clinical Pharmacy, Imam
Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
(3)Department of Natural Products and Alternative Medicines, College of Clinical
Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
(4)Department of Pharmaceutics, College of Clinical Pharmacy, Imam Abdulrahman
Bin Faisal University, Dammam 31441, Saudi Arabia.
DOI: 10.4103/jpbs.JPBS_189_17
PMCID: PMC5810075
PMID: 29456376
High School Students Are a Target Group for Fight against Self-Medication with
Antimalarial Drugs: A Pilot Study in University of Kinshasa, Democratic Republic
of Congo.
Author information:
(1)Centre Hospitalier du Mont Amba, University of Kinshasa, Kinshasa, Democratic
Republic of the Congo; Centre de Santé Universitaire, University of Kinshasa,
Kinshasa, Democratic Republic of the Congo.
(2)Division of Hemato-Oncology and Nephrology, Department of Pediatrics,
University Hospital of Kinshasa, School of Medicine, University of Kinshasa,
Kinshasa, Democratic Republic of the Congo.
DOI: 10.1155/2016/6438639
PMCID: PMC4909922
PMID: 27340411
155. Learn Mem. 2016 Sep 15;23(10):515-33. doi: 10.1101/lm.042192.116. Print 2016
Oct.
Author information:
(1)Department of Biobehavioral Health, Penn State University, University Park,
Pennsylvania 16802, USA.
(2)Department of Biobehavioral Health, Penn State University, University Park,
Pennsylvania 16802, USA thomas.gould@psu.edu.
It has long been hypothesized that conditioning mechanisms play major roles in
addiction. Specifically, the associations between rewarding properties of drugs
of abuse and the drug context can contribute to future use and facilitate the
transition from initial drug use into drug dependency. On the other hand, the
self-medication hypothesis of drug abuse suggests that negative consequences of
drug withdrawal result in relapse to drug use as an attempt to alleviate the
negative symptoms. In this review, we explored these hypotheses and the
involvement of the hippocampus in the development and maintenance of addiction to
widely abused drugs such as cocaine, amphetamine, nicotine, alcohol, opiates, and
cannabis. Studies suggest that initial exposure to stimulants (i.e., cocaine,
nicotine, and amphetamine) and alcohol may enhance hippocampal function and,
therefore, the formation of augmented drug-context associations that contribute
to the development of addiction. In line with the self-medication hypothesis,
withdrawal from stimulants, ethanol, and cannabis results in
hippocampus-dependent learning and memory deficits, which suggest that an attempt
to alleviate these deficits may contribute to relapse to drug use and maintenance
of addiction. Interestingly, opiate withdrawal leads to enhancement of
hippocampus-dependent learning and memory. Given that a conditioned aversion to
drug context develops during opiate withdrawal, the cognitive enhancement in this
case may result in the formation of an augmented association between
withdrawal-induced aversion and withdrawal context. Therefore, individuals with
opiate addiction may return to opiate use to avoid aversive symptoms triggered by
the withdrawal context. Overall, the systematic examination of the role of the
hippocampus in drug addiction may help to formulate a better understanding of
addiction and underlying neural substrates.
© 2016 Kutlu and Gould; Published by Cold Spring Harbor Laboratory Press.
DOI: 10.1101/lm.042192.116
PMCID: PMC5026208
PMID: 27634143 [Indexed for MEDLINE]
Author information:
(1)Assistant Professor, Social Determinants of Health Research Centre, Qazvin
University of Medical Sciences, Qazvin, Iran.
(2)Associate Professor, Department of Nursing, Faculty of Nursing and Midwifery,
Qazvin University of Medical Sciences, Qazvin, Iran.
DOI: 10.7860/JCDR/2017/25368.10495
PMCID: PMC5620792
PMID: 28969151
Locquet M(1), Beaudart C(2), Larbuisson R(3), Leclercq V(2), Buckinx F(2), Kaux
JF(4)(5), Reginster JY(2), Bruyère O(2)(4).
Author information:
(1)Department of Public Health, Epidemiology and Health Economics, University of
Liège, Liège, Belgium. medea.locquet@ulg.ac.be.
(2)Department of Public Health, Epidemiology and Health Economics, University of
Liège, Liège, Belgium.
(3)Department of Anesthesiology-Reanimation, University of Liège, Liège, Belgium.
(4)Department of Sports and Rehabilitation Sciences, University of Liège, Liège,
Belgium.
(5)Department of Physical Medicine, Rehabilitation and Sport Traumatology,
SPORTS2, FIFA Medical Centre of Excellence, University and University Hospital of
Liège, Liège, Belgium.
DOI: 10.1007/s12325-016-0426-2
PMCID: PMC5126181
PMID: 27796913 [Indexed for MEDLINE]
158. Int J Environ Res Public Health. 2015 Jun 17;12(6):7002-16. doi:
10.3390/ijerph120607002.
Pavydė E(1), Veikutis V(2), Mačiulienė A(3), Mačiulis V(4), Petrikonis K(5),
Stankevičius E(6).
Author information:
(1)Institute of Physiology and Pharmacology, Lithuanian University of Health
Sciences, A. Mickeviciaus Str. 9, Kaunas 44307, Lithuania.
egle.svitojute@lsmuni.lt.
(2)Institute of Microbiology and Virology, Lithuanian University of Health
Sciences, Kaunas 49264, Lithuania. vincentas.veikutis@med.kmu.lt.
(3)Department of Anesthesiology, Lithuanian University of Health Sciences, Kaunas
50161, Lithuania. asta.svitojute@gmail.com.
(4)Department of Anesthesiology, Lithuanian University of Health Sciences, Kaunas
50161, Lithuania. vt.maciulis@gmail.com.
(5)Department of Neurology, Lithuanian University of Health Sciences, Kaunas
50161, Lithuania. kestutispetrikonis@yahoo.com.
(6)Institute of Physiology and Pharmacology, Lithuanian University of Health
Sciences, A. Mickeviciaus Str. 9, Kaunas 44307, Lithuania.
edgaras.stankevicius@lsmuni.lt.
DOI: 10.3390/ijerph120607002
PMCID: PMC4483745
PMID: 26090612 [Indexed for MEDLINE]
Self-Care in the Twenty First Century: A Vital Role for the Pharmacist.
Author information:
(1)University of Technology Sydney, 15 Broadway, Ultimo, NSW, 2007, Australia.
john.bell@nexonline.com.au.
(2)World Self-Medication Industry (WSMI), Nyon, Switzerland.
(3)Global R&D, Pfizer Consumer Healthcare, Madison, NJ, USA.
(4)GI & Liver Center, Bangkok Medical Center, Chulalongkorn University, Bangkok,
Thailand.
DOI: 10.1007/s12325-016-0395-5
PMCID: PMC5055554
PMID: 27535290 [Indexed for MEDLINE]
Blanke C(1)(2), LeBlanc M(2), Hershman D(2), Ellis L(2), Meyskens F(2).
Author information:
(1)SWOG Group Chair's Office, Portland, Oregon.
(2)SWOG Executive Advisory Committee, Portland, Oregon.
Erratum in
JAMA Oncol. 2017 Oct 1;3(10):1431.
JAMA Oncol. 2017 Oct 1;3(10):1431.
DOI: 10.1001/jamaoncol.2017.0243
PMCID: PMC5824315
PMID: 28384683 [Indexed for MEDLINE]
Vrolijk MF(1), Opperhuizen A(2)(3), Jansen EH(4), Bast A(2), Haenen GR(2).
Author information:
(1)Department of Pharmacology and Toxicology, Maastricht University, Maastricht,
The Netherlands. m.vrolijk@maastrichtuniversity.nl.
(2)Department of Pharmacology and Toxicology, Maastricht University, Maastricht,
The Netherlands.
(3)Netherlands Food and Consumer Product Safety Authority (NVWA), Utrecht, The
Netherlands.
(4)National Institute for Public Health and the Environment (RIVM), Bilthoven,
The Netherlands.
DOI: 10.1111/bcpt.12603
PMID: 27061346 [Indexed for MEDLINE]
Author information:
(1)Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke
University, BOX 3903, Durham, NC, USA. Electronic address: ji.yeun.park@duke.edu.
(2)Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke
University, BOX 3903, Durham, NC, USA; Department of Medicine, School of
Medicine, Duke University, Durham, NC, USA; Duke Clinical Research Institute,
Duke University Medical Center, Durham, NC, USA; Center for Child and Family
Policy, Sanford School of Public Policy, Duke University, Durham NC, USA.
Electronic address: litzy.wu@duke.edu.
BACKGROUND: The use of marijuana for medical purposes is now legal in some U.S.
states and other jurisdictions, such as Canada, and Israel. Despite the
widespread legalization of medical marijuana globally, there is limited
information on patterns and correlates of medical marijuana use (MMU). We
conducted a literature review to assess prevalence, reasons, perceived effects,
and correlates of MMU among adolescents and adults.
METHODS: We searched peer-reviewed articles in English between January 1996 and
August 2016 from several databases (PubMed, Google Scholar, Embase, CINAHL, and
PsycINFO) using different combinations of keywords.
RESULTS: A total of 25 articles met the inclusion criteria. In the U.S., national
survey estimates of prescribed MMU was 1.1% among 12th graders and 17% among
adults who reported past-year marijuana use. The reported prevalence of
prescribed MMU ranged from <1.7% in Israeli cancer patients to 17.4% in American
health care patients. The reported prevalence of self-medication with marijuana
ranged from 15% in Canadian patients with chronic pain to 30% in British patients
with multiple sclerosis. Pain was the most frequently endorsed reason for use.
MMU appeared to provide symptom relief for a range of pain conditions, sleep
disturbance, and anxiety symptoms, but it did not appear to provide sufficient
relief of cluster headache symptoms. Non-medical marijuana use was a common
factor associated with MMU across studies.
CONCLUSION: Either MMU or self-medication with marijuana was common, mainly due
to pain management. Additional research is needed to evaluate temporal and causal
associations of non-medical marijuana use with MMU.
DOI: 10.1016/j.drugalcdep.2017.03.009
PMCID: PMC5542049
PMID: 28549263 [Indexed for MEDLINE]
163. Trans R Soc Trop Med Hyg. 2019 Apr 1;113(4):183-188. doi:
10.1093/trstmh/try138.
Hertz JT(1), Madut DB(2), Tesha RA(3), William G(4), Simmons RA(5), Galson SW(1),
Maro VP(4), Crump JA(6), Rubach MP(2).
Author information:
(1)Department of Surgery, Division of Emergency Medicine, Duke University Medical
Center, 2301 Erwin Rd, Durham, NC, USA.
(2)Department of Medicine, Division of Infectious Disease, Duke University
Medical Center, 2301 Erwin Rd, Durham, NC, USA.
(3)Department of Statistical Science, Duke University, Durham, NC, USA.
(4)Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
(5)Duke Global Health Institute, Duke University, 310 Trent Dr, Durham, NC, USA.
(6)Otago Global Health Institute, University of Otago, Dunedin, New Zealand.
DOI: 10.1093/trstmh/try138
PMCID: PMC6432801
PMID: 30597114
Stolbizer F(1)(2), Roscher DF(3), Andrada MM(3), Faes L(2), Arias C(2), Siragusa
C(3)(2), Prada S(2), Saiegh J(2), Rodríguez D(2), Gualtieri A(4), Mendez
CF(5)(6).
Author information:
(1)Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Cirugía y
Traumatología Bucomaxilofacial II, Buenos Aires, Argentina. fstolbizer@gmail.com.
(2)Universidad de Buenos Aires, Facultad de Odontología, Servicio de Emergencias,
Buenos Aires, Argentina.
(3)Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Cirugía y
Traumatología Bucomaxilofacial II, Buenos Aires, Argentina.
(4)Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Biofísica y
Bioestadística, Buenos Aires, Argentina.
(5)Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Farmacología,
Buenos Aires, Argentina.
(6)CONICET-Universidad de Buenos Aires, Instituto de investigaciones Biomédicas
(INBIOMED), Buenos Aires, Argentina.
The aims of this work were: To determine what percentage of firsttime patients to
the Dental Emergency Department at the School of Dentistry of Buenos Aires
University had taken medications to relieve or treat their condition. To
determine what percentage of these had used selfmedication, and which were the
most frequently taken medicines. To determine whether there is an association
between selfmedication and educational level, and between selfmedication and
whether the patient has health coverage. This was an observational,
crosssectional study which reviewed 567 clinical histories of patients who
visited the Dental Emergency Department from March 2015 to September 2016. The
following parameters were assessed: sex, age, reason for consultation,
medication, dose, interval, duration and indication. Patients' educational level
and whether they had health coverage were ascertained. Confidence intervals of
95% were calculated for percentages using the Wilson score method. Inferential
analyses were performed using the Chisquare test (ᵪ2). Significance level was set
at 5%. Eighty five percent (85%,.n=481) of the patients had taken at least one
medication; 77% (n=372) had used selfmedication. The most frequently used
medicines were nonsteroid antiinflammatory drugs (61%), antibiotics (34%) and
glucocorticoids (2%). No association was found between selfmedication and
patients' having health coverage (ᵪ2=13; p=0.08). No significant association was
found between educational level and selfmedication (ᵪ2=10; p=0.22). Nevertheless,
the lowest percentages of selfmedication were found in subjects with complete
university studies (77%; CI95: 60% to 89%), while the highest percentages were
found in subjects with incomplete primary education (89%; CI95: 69% to 97%),
complete primary education (92%; CI95: 82% to 96%) and incomplete secondary
educations (90%; CI95: 84% to 94%).High levels of selfmedication were found in
the study population. Although no association was found between educational level
and selfmedication behavior, the percentage of selfmedication was higher among
patients with lower educational levels. The high level of selfmedication
highlights the importance of conducting campaigns to raise awareness about the
adequate use of medicines.
Publisher: Los objetivos del presente trabajo fueron: Determinar qué porcentaje
de pacientes que concurrió por primera vez al Servicio de Urgencias de la
Facultad de Odontología de la Universidad de Buenos Aires consumió medicamentos
para aliviar o tratar su dolencia. Determinar qué porcentaje de pacientes fueron
automedicados, y cuáles fueron los medica mentos más utilizados. Determinar si
existe relación entre la automedicación y el nivel de estudio y entre la
automedicación y la presencia de cobertura médica. Se realizó un estudio
observacional y transversal. Se relevaron 567 historias clínicas de pacientes que
concurrieron entre marzo 2015 y septiembre 2016 y se valoraron los siguientes
parámetros: sexo, edad, origen de la consulta, medicación, dosis, intervalo,
duración, e indicación. Se indagó el nivel educacional alcanzado y la existencia
de cobertura médica. Se calcularon intervalos de confianza al 95% para
porcentajes mediante el método score de Wilson. Se realizaron análisis
inferenciales mediante la prueba Chicuadrado (ᵪ2). Se fijó un nivel de
significación del 5%. El 85% (n=481) de los pacientes había consumido al menos un
medicamento. El 77% (n=372) de los pacientes estaba autome dicado. Los
medicamentos más utilizados fueron antiinflamatorios no esteoroideos (61%),
antibióticos (34%) y glucocorticoides (2%). No se encontró asociación entre la
automedicación y la presencia de cobertura médica (ᵪ2=13; p=0,08). No se encontró
asociación significativa entre el nivel de estudios y la automedicación (ᵪ2=10;
p=0,22). Sin embargo, los sujetos con estudio universitario completo presentaron
el menor porcentaje de automedicación (77%; IC95: 60% a 89%), mientras que los
mayores porcentajes se encontraron en sujetos con primario incompleto (89%; IC95:
69% a 97%), primario completo (92%; IC95: 82% a 96%) y secundario incompleto
(90%; IC95: 84% a 94%). Se encontraron niveles elevados de automedicación en la
población estudiada. Si bien no se observó asociación entre nivel educativo y la
conducta de automedicación, fue mayor el porcentaje de automedicación en
pacientes con menor nivel educativo. La alta presencia de automedicación refuerza
la importancia de realizar campañas de concientización sobre el consumo adecuado
de medicamentos.
Sociedad Argentina de Investigación Odontológica.
Al Essa M(1)(2)(3), Alshehri A(1), Alzahrani M(1), Bustami R(1), Adnan S(1),
Alkeraidees A(1), Mudshil A(1), Gramish J(1)(2).
Author information:
(1)College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences,
P.O. BOX 3660, Riyadh 11426, Saudi Arabia.
(2)Pharmaceutical Care Services, King Abdulaziz Medical City, Riyadh, MC 1445,
Saudi Arabia.
(3)King Abdullah International Medical Research Center (KAIMRC), Riyadh 14611,
Saudi Arabia.
DOI: 10.1016/j.jsps.2018.11.004
PMCID: PMC6362167
PMID: 30766435
166. Medicines (Basel). 2018 Jan 6;5(1). pii: E3. doi: 10.3390/medicines5010003.
Hoshino T(1), Muto N(2), Tsukada S(3), Nakamura T(4)(5), Maegawa H(6).
Author information:
(1)Office of Planning and Coordination, Pharmaceuticals and Medical Devices
Agency, Tokyo 100-0013, Japan. hoshino-tatsuro@pmda.go.jp.
(2)Office of OTC/Quasi-drugs, Pharmaceuticals and Medical Devices Agency, Tokyo
100-0013, Japan. muto-nanami@pmda.go.jp.
(3)Office of New drugs IV, Pharmaceuticals and Medical Devices Agency, Tokyo
100-0013, Japan. tsukada-shinsuke@pmda.go.jp.
(4)Office of OTC/Quasi-drugs, Pharmaceuticals and Medical Devices Agency, Tokyo
100-0013, Japan. cba07499@nifty.com.
(5)Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of
Health Sciences, Kanagawa 210-9501, Japan. cba07499@nifty.com.
(6)Office of Vaccines and Blood Products, Pharmaceuticals and Medical Devices
Agency, Tokyo 100-0013, Japan. maegawa-hikoichiro@pmda.go.jp.
DOI: 10.3390/medicines5010003
PMCID: PMC5874568
PMID: 29316611
Author information:
(1)Department of Clinical Pharmacy and Pharmaceutical Care, Faculty of Pharmacy,
Medical University of Warsaw, ul. Banacha 1, 02-097, Warsaw, Poland.
anna.piecuch@wum.edu.pl.
(2)Department of Clinical Pharmacy and Pharmaceutical Care, Faculty of Pharmacy,
Medical University of Warsaw, ul. Banacha 1, 02-097, Warsaw, Poland.
DOI: 10.1007/s11096-016-0397-z
PMCID: PMC5306170
PMID: 27905078 [Indexed for MEDLINE]
168. J Gen Fam Med. 2017 Jul 24;18(6):336-340. doi: 10.1002/jgf2.81. eCollection
2017
Dec.
Reasons for the preference of clinic visits to self-medication by common cold
patients in Japan.
Tsutsumi M(1)(2), Shaku F(3)(4), Ozone S(2)(5), Sakamoto N(2)(5), Maeno T(2)(5).
Author information:
(1)Himawari Home Clinic Sumino-kai Healthcare Corporation Chiba Japan.
(2)Primary Care and Medical Education Faculty of Medicine University of Tsukuba
Tsukuba Japan.
(3)Division of Respiratory Medicine Department of Internal Medicine Nihon
University School of Medicine Tokyo Japan.
(4)Department of Psychosomatic Internal Medicine Nihon University Itabashi
Hospital Tokyo Japan.
(5)General Medicine and Primary Care University of Tsukuba Hospital Tsukuba
Japan.
Background: Many Japanese visit medical institutions for common cold treatment,
which can cause congestion in these institutions and an increase in medical
expenses, although the common cold can be treated sufficiently through
self-medication. Therefore, to elucidate the reasons individuals with common
colds do not use over-the-counter (OTC) medication, we conducted an investigation
using a self-administered inquiry sheet to determine reasons for clinic visits
and for the avoidance of OTC medication.
Methods: The study was of patients with self-diagnosed common cold symptoms using
an anonymous self-report questionnaire.
Results: Of the 471 patients administered the questionnaire, 442 responded. The
analysis was focused on the 37 patients who responded that they had considered
using OTC medication before coming to the clinic but decided against it and came
to the clinic instead. The majority responded positively saying that they felt
reassured when seen by a physician (91.9%) and that their common cold was cured
more rapidly (89.2%).
Conclusions: It can be presumed that many patients with common colds visit
medical institutions because they feel reassured and feel that their symptoms
improve at a quicker rate. The findings of this study indicated that there is a
need for accurate information and relief from anxiety for patients regarding the
common cold.
DOI: 10.1002/jgf2.81
PMCID: PMC5729384
PMID: 29264062
Author information:
(1)The University of Maryland at College Park, Center for Addictions,
Personality, and Emotion Research, Cole Activities Building Suite 2103-D, College
Park, MD 20742, United States.
(2)The University of North Carolina at Chapel Hill, CB#3270 Davie Hall, Chapel
Hill, NC 27599, United States.
DOI: 10.1177/0265407513516889
PMCID: PMC4245029
PMID: 25473144
Author information:
(1)Department of Microbiology, Faculty of Science, Federal University, Birnin
Kebbi, Kalgo Road P.M.B. 1157, Birnin Kebbi 860222, Kebbi State, Nigeria.
olumide.ajibola@fubk.edu.ng.
(2)Department of Demography and Social Statistics, Faculty of Art, Social and
Management Sciences, Federal University Birnin Kebbi, Kalgo Road P.M.B. 1157,
Birnin Kebbi 860222, Kebbi State, Nigeria. omisakinolusola@yahoo.com.
(3)Department of Medical Biochemistry, University of Nigeria, Enugu Campus, Enugu
400241, Nigeria. anthonius.eze@unn.edu.ng.
(4)Immunization, Vaccines and Emergencies, World Health Organization, Kebbi State
Field Office, Birnin Kebbi 860222, Nigeria. omolekes@who.int.
DOI: 10.3390/diseases6020032
PMCID: PMC6023284
PMID: 29702565
Author information:
(1)Amandine Luquiens, Amine Benyamina, Henri-Jean Aubin, Hôpital Paul
Brousse-Addictologie, 94804 Villejuif cedex, France.
DOI: 10.3748/wjg.v21.i20.6381
PMCID: PMC4445116
PMID: 26034374 [Indexed for MEDLINE]
Brusa P(1)(2), Allais G(3)(4), Scarinzi C(5), Baratta F(1), Parente M(1), Rolando
S(3), Gnavi R(5), Spadea T(5), Costa G(5), Benedetto C(3), Mana M(6), Giaccone
M(2)(7), Mandelli A(7), Manzoni GC(4), Bussone G(4).
Author information:
(1)Department of Science and Technology of Drugs, University of Turin, Turin,
Italy.
(2)Order of Pharmacists of Turin, Turin, Italy.
(3)Department of Surgical Sciences, Women's Headache Center, University of Turin,
Turin, Italy.
(4)FI.CEF Onlus, Italian Headache Foundation, Milan, Italy.
(5)Epidemiology Unit, ASL TO3, Grugliasco (Turin), Italy.
(6)ATF Informatics, Cuneo, Italy.
(7)FOFI, Federation of the Orders of Italian Pharmacists, Rome, Italy.
Headache disorders are considered the second leading cause of years lived with
disability worldwide, and 90% of people have a headache episode at least once a
year, thus representing a relevant public health priority. As the pharmacist is
often the first and only point of reference for people complaining of headache,
we carried out a survey in a nationwide sample of Italian pharmacies, in order to
describe the distribution of migraine or non-migraine type headaches and
medicines overuse among people entering pharmacies seeking for self-medication;
and to evaluate the association, in particular of migraine, with
socio-demographic and clinical characteristics, and with the pathway of care
followed by the patients. A 14-item questionnaire, including socio-demographic
and clinical factors, was administered by trained pharmacists to subjects who
entered a pharmacy requesting self-medication for a headache attack. The ID
Migraine™ Screener was used to classify headache sufferers in four classes. From
June 2016 to January 2017, 4424 people have been interviewed. The prevalence of
definite migraines was 40%, significantly higher among women and less educated
people. About half of all headache sufferers and a third of migraineurs do not
consider their condition as a disease and are not cared by any doctor. Among
people seeking self-medication in pharmacies for acute headache attacks, the rate
of definite or probable migraine is high, and a large percentage of them is not
correctly diagnosed and treated. The pharmacy can be a valuable observatory for
the study of headaches, and the first important step to improve the quality of
care delivered to these patients.
DOI: 10.1371/journal.pone.0211191
PMCID: PMC6343913
PMID: 30673780
Paut KM(1), Tomic Z(1), Bukumiric Z(2), Trivic B(1), Sabo A(1).
Author information:
(1)Faculty of Medicine, Novi Sad, Serbia and Montenegro.
(2)Faculty of Medicine, Belgrade, Serbia and Montenegro.
DOI: 10.1016/j.jval.2014.08.1051
PMID: 27201082
Pereira de Paula BA(1), da Silva Alves GC(1), PercÍnio Á(1), Pereira ML(1),
Moraes JT(1), Sanches C(1).
Author information:
(1)Federal University of São João Del Rei, Bairro Chanadour, Divinópolis, Brazil.
Belkina T(1), Duvanova N(2), Karbovskaja J(3), Tebbens JD(4), Vlcek J(2).
Author information:
(1)Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec
Kralove, Charles University, Heyrovskeho 1203, Hradec Kralove, 50005, Czech
Republic. belkinat@faf.cuni.cz.
(2)Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec
Kralove, Charles University, Heyrovskeho 1203, Hradec Kralove, 50005, Czech
Republic.
(3)Department of Technology of Dosage Forms, Saint Petersburg State Chemical -
Pharmaceutical Academy, Prof. Popova Str. 14, Saint Petersburg, 197376, Russian
Federation.
(4)Department of Biophysics and Physical Chemistry, Faculty of Pharmacy in Hradec
Kralove, Charles University, Heyrovskeho 1203, Hradec Kralove, 50005, Czech
Republic.
DOI: 10.1186/s40360-017-0116-y
PMCID: PMC5307805
PMID: 28193258 [Indexed for MEDLINE]
Author information:
(1)Instituto Superior de Ciências de Saúde - ISCISA (High Institute for Health
Sciences), Maputo, Mozambique. torresneusa@gmail.com.
(2)Discipline of Public Health Medicine, School of Nursing and Public Health,
University of KwaZulu Natal, Durban, South Africa. torresneusa@gmail.com.
(3)Discipline of Public Health Medicine, School of Nursing and Public Health,
University of KwaZulu Natal, Durban, South Africa.
(4)School of Health Sciences, University of KwaZulu Natal, Durban, South Africa.
BACKGROUND: The Sustainable Development Goals (SDGs) emphasize the need for
strengthening the capacity of all developing countries in the early warning, risk
reduction and management of national as well as global health risks. Despite
there being a considerable amount of effort in controlling and promoting the
rational use of antibiotics, studies show that the practice of self-medication
with antibiotics (SMA) systematically exposes individuals to the risk of
antibiotic resistance and other antibiotic side effects. The proposed scoping
review aims to map literature on the factors influencing self-medication with
antibiotics in low- and middle-income countries (LMICs).
METHODS AND ANALYSIS: The adopted search strategy for this scoping review study
will involve electronic databases including PubMed, Web of Knowledge, Science
Direct, EBSCOhost (PubMed, CINAHL, MEDLINE), Google Scholar, BioMed Central and
World Health Organization library. A two-stage mapping strategy will be
conducted. Stage 1 will screen studies through examining their titles and
screening abstracts descriptively by focus and method as stipulated by the
inclusion and exclusion criteria. In stage 2, the researchers will extract data
from the included studies. A parallel screening and data extraction will be
undertaken by two reviewers. In accessing the quality of the included studies,
the researchers will utilize the mixed methods appraisal tool (MMAT, version 11).
The NVivo computer software (version 11) shall be used to classify, sort, arrange
and examine relationships in the data, and to extract the relevant outcomes and
for the thematic analysis of the studies.
DISCUSSION: The study anticipates finding relevant studies reporting evidence on
the factors influencing self-medication with antibiotics in LMICs. The evidence
obtained from the included studies will help guide future research. The study
findings will be disseminated electronically and in print with presentations
being done at relevant platforms, i.e. conferences related to antibiotic use,
antimicrobial resistance, health seeking behaviour and the use of medicines.
SYSTEMATIC REVIEW REGISTRATION: Prospero Registration Number: CRD42017072954.
DOI: 10.1186/s13643-018-0758-x
PMCID: PMC6054840
PMID: 30031404 [Indexed for MEDLINE]
Navaro M(1), Vezzosi L(1), Santagati G(1), Angelillo IF(1); Collaborative Working
Group.
Author information:
(1)Department of Experimental Medicine of the University of Campania "Luigi
Vanvitelli", Naples, Italy.
The study assessed knowledge, attitudes, and medication use of a random sample of
pregnant women attending outpatient Gynecology and Obstetrics clinics at randomly
selected public General and Teaching hospitals in Naples, Italy. A total of 503
women participated. Those more likely to know that a pregnant woman with chronic
condition must discuss whether or not to take a medication with the physician
were Italian, aged 31-40 years, employed, with no history of abortion, having had
a medical problem within the previous year, with a better self-perceived health
status, who knew how to use medications during pregnancy, and who needed
information on medications. The knowledge of the potential risk of using
non-prescribed medications during pregnancy was significantly higher in employed
women, who received information from physicians, who knew how to use medications
during pregnancy, and who knew the possible damages related to medications use.
More than half had used at least one medication. Those aged 26-35 years, Italian,
non-graduated, in the third trimester, having had a medical problem within the
previous year, with a risky pregnancy, and with a knowledge that women with
chronic condition must discuss whether or not to take a medication with the
physician were more likely to use medication. Less than half had used medication
without a physician's advice. Those who were more likely to self-medicate were
older, Italian, multiparous, with no history of abortion, who knew that women
with chronic condition must discuss whether or not to take a medication with the
physician, who did not know the potential risk of using non-prescribed medication
during pregnancy, who had used prescribed medication during pregnancy, and who
needed information about medications. Educational programs for women about
medication use are important to increase their knowledge of the potential risks
to the pregnant women and the unborn child in order to reduce self-medication.
DOI: 10.1371/journal.pone.0198618
PMCID: PMC6007931
PMID: 29920515 [Indexed for MEDLINE]
Conflict of interest statement: The authors have declared that no competing
interests exist.
Akram A(1), Maqsood U(1), Latif MZ(2), Arshad HS(1), Riaz H(2), Qureshi MA(2).
Author information:
(1)Department of Physical Therapy, Azra Naheed Medical College, The Superior
University, Lahore.
(2)Azra Naheed Medical College, The Superior University Lahore, Pakistan.
PMID: 31000857
Work Stress and Alcohol Use: Developing and Testing a Biphasic Self-Medication
Model.
Frone MR(1).
Author information:
(1)State University of New York at Buffalo.
This study developed and tested a moderated-mediation model of work stress and
alcohol use, based on the biphasic (stimulant and sedative) effects of alcohol
and the self-medication and stress-vulnerability models of alcohol use. The model
proposes that exposure to work stressors can increase both negative affect and
work fatigue, and that these two sources of strain can subsequently motivate the
use of alcohol. However, the relations of negative affect and work fatigue to
alcohol use are conditional on the joint moderating effects of alcohol outcome
expectancies and gender. Data were collected from a national probability sample
of 2,808 U.S. workers. Supporting the model, the results indicated that work
stressor exposure was conditionally related via negative affect to heavy alcohol
use among both men and women holding strong tension reduction alcohol
expectancies and to after work alcohol use among men holding strong tension
reduction alcohol expectancies. Also, work stressor exposure was conditionally
related via work fatigue to both heavy alcohol use and workday alcohol use among
men holding strong fatigue reduction alcohol expectancies. The results have
application in the identification of individuals at higher risk of problematic
alcohol use and are relevant to workplace safety and to the design of appropriate
interventions.
DOI: 10.1080/02678373.2016.1252971
PMCID: PMC5228600
PMID: 28090129
Dror DM(1), Chakraborty A(2), Majumdar A(1), Panda P(1), Koren R(3).
Author information:
(1)Micro Insurance Academy, New Delhi, India and Institute of Health Policy &
Management, Erasmus University, Rotterdam, The Netherlands.
(2)Micro Insurance Academy, New Delhi, India and Institute of Health Policy &
Management, Erasmus University, Rotterdam, The Netherlands; Public Health
Foundation of India, Gurgaon, India, .
(3)Tel Aviv University, Rabin Medical Center, Petah Tikva, Israel.
DOI: 10.4103/0971-5916.192075
PMCID: PMC5094122
PMID: 27748307 [Indexed for MEDLINE]
Botyar M(1), Kashanian M(1), Abadi ZRH(1), Noor MH(1), Khoramroudi R(1),
Monfaredi M(2), Nasehe G(1).
Author information:
(1)Department of Midwifery, University of Medical Sciences, Tehran, Iran.
(2)Department of Biology, Islamic Azad University, Karaj Branch, Karaj, Iran.
DOI: 10.4103/jfmpc.jfmpc_227_17
PMCID: PMC5958553
PMID: 29915745
Ramana Reddy AM(1), Prashanth LK(1), Sharat Kumar GG(1), Chandana G(1), Jadav
R(1).
Author information:
(1)Advanced Neurosciences Institute, BGS Global Hospital, Bangalore, Karnataka,
India.
Intracranial hypertension (idiopathic-IIH and secondary) is a potentially
treatable condition. Although various factors such as female gender and obesity,
certain drugs have been implicated as risk factors for IIH, there remains a lack
of clarity in the exact causal-effect relationship. In India, self-medication by
obtaining drugs over the counter due to lack of adequate drug regulation and
ignorance of the public is a very common practice with a potential for severe
adverse effects. We present a case of a young lady who has developed intracranial
hypertension possibly due to self-medication with steroids and cyproheptadine,
obtained over the counter.
DOI: 10.4103/0976-3147.139991
PMCID: PMC4173236
PMID: 25288841
183. Med J Islam Repub Iran. 2017 Dec 22;31:119. doi: 10.14196/mjiri.31.119.
eCollection 2017.
Author information:
(1)Health Promotion Research Center, Iran University of Medical Sciences, Tehran,
Iran.
(2)School of Health, Iran University of Medical Sciences, Tehran, Iran.
(3)Department of Biostatistics, School of Health, Iran University of Medical
Sciences, Tehran, Iran.
DOI: 10.14196/mjiri.31.119
PMCID: PMC6014786
PMID: 29951420
184. Int J Environ Res Public Health. 2018 Apr 5;15(4). pii: E687. doi:
10.3390/ijerph15040687.
Author information:
(1)Zhejiang University Institute of Social Medicine, 866 Yuhangtang Road,
Hangzhou 310058, Zhejiang, China. ellen_wang@zju.edu.cn.
(2)Department of Social and Behavioral Sciences, Harvard T.H. Chan School of
Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.
llin@hsph.harvard.edu.
(3)Center for Community-Based Research, Dana-Farber Cancer Institute, 450
Brookline Avenue, Boston, MA 02215, USA. llin@hsph.harvard.edu.
(4)Division of Policy Translation and Leadership Development, Harvard T.H. Chan
School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.
llin@hsph.harvard.edu.
(5)Department of Community Health Sciences, Boston University School of Public
Health, 801 Massachusetts Ave, Boston, MA 02118, USA. zxuan@bu.edu.
(6)Zhejiang University Institute of Social Medicine, 866 Yuhangtang Road,
Hangzhou 310058, Zhejiang, China. lilu@zju.edu.cn.
(7)Zhejiang University Institute of Social Medicine, 866 Yuhangtang Road,
Hangzhou 310058, Zhejiang, China. zhouxudong@zju.edu.cn.
DOI: 10.3390/ijerph15040687
PMCID: PMC5923729
PMID: 29621165 [Indexed for MEDLINE]
The link between schizophrenia and substance use disorder: A unifying hypothesis.
Khokhar JY(1), Dwiel LL(1), Henricks AM(1), Doucette WT(1), Green AI(2).
Author information:
(1)Department of Psychiatry, Geisel School of Medicine at Dartmouth, United
States.
(2)Department of Psychiatry, Geisel School of Medicine at Dartmouth, United
States; Department of Molecular and Systems Biology, Geisel School of Medicine at
Dartmouth, United States; Dartmouth Clinical and Translational Science Institute,
Dartmouth College, United States. Electronic address: Alan.I.Green@dartmouth.edu.
DOI: 10.1016/j.schres.2017.04.016
PMCID: PMC6094954
PMID: 28416205 [Indexed for MEDLINE]
Mahrous MS(1).
Author information:
(1)Department of Medical Education, College of Dentistry, Taibah University,
Madinah, Saudi Arabia.
PMCID: PMC6124833
PMID: 30202401
187. Soc Sci Med. 2016 Mar;152:1-8. doi: 10.1016/j.socscimed.2016.01.022. Epub 2016
Jan 18.
Author information:
(1)Department of General Practice, School of Primary Care, Faculty of Medicine
Nursing and Health Sciences, Monash University, Australia. Electronic address:
bianca.brijnath@monash.edu.
(2)Department of General Practice, School of Primary Care, Faculty of Medicine
Nursing and Health Sciences, Monash University, Australia.
The current study examines how the neoliberal imperative to self-manage has been
taken up by patients, focusing specifically on Indian-Australians and
Anglo-Australians living with depression in Australia. We use Nikolas Rose's work
on governmentality and neoliberalism to theorise our study and begin by
explicating the links between self-management, neoliberalism and the Australian
mental health system. Using qualitative methods, comprising 58 in-depth
interviews, conducted between May 2012 and May 2013, we argue that participants
practices of self-management included reduced use of healthcare services,
self-medication and self-labour. Such practices occurred over time, informed by
unsatisfactory interactions with the health system, participants confidence in
their own agency, and capacity to craft therapeutic strategies. We argue that as
patients absorbed and enacted neoliberal norms, a disconnect was created between
the policy rhetoric of self-management, its operationalisation in the health
system and patient understandings and practices of self-management. Such a
disconnect, in turn, fosters conditions for risky health practices and poor
health outcomes.
Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.socscimed.2016.01.022
PMID: 26820111 [Indexed for MEDLINE]
OUTPATIENT MEDICATION USE AND IMPLICATIONS FOR DENTAL CARE: GUIDANCE FOR
CONTEMPORARY DENTAL PRACTICE.
Author information:
(1)Catherine St, Ottawa ON K2P 2G8.
Author information:
(1)Department of Family and Preventive Medicine, University of Utah.
Comment in
Fam Med. 2015 Jun;47(6):487-8.
Fam Med. 2015 Jun;47(6):488-9.
Self-medication with over the counter drugs, prevalence of risky practice and its
associated factors in pharmacy outlets of Asmara, Eritrea.
Tesfamariam S(1), Anand IS(2), Kaleab G(3), Berhane S(3), Woldai B(2), Habte
E(4), Russom M(5).
Author information:
(1)School of Pharmacy, Asmara College of Health Sciences, Asmara, Eritrea.
sirakino2015@gmail.com.
(2)Pharmacology and Clinical Pharmacy Unit, School of Pharmacy, Asmara College of
Health Sciences, Asmara, Eritrea.
(3)School of Pharmacy, Asmara College of Health Sciences, Asmara, Eritrea.
(4)Biostatistics and Epidemiology Unit, School of Public Health, Asmara College
of Health Sciences, Asmara, Eritrea.
(5)Eritrean Pharmacovigilance Centre, National Medicine and Food Administration,
Ministry of Health, Asmara, Eritrea.
BACKGROUND: Although over the counter (OTC) drugs are believed to be relatively
safe, their inappropriate use could have serious implications. The aim of the
study was to assess the practice of self-medication, prevalence of risky practice
and its associated factors in pharmacy outlets of Asmara, Eritrea.
METHODS: A descriptive cross-sectional study was conducted among 609 customers in
20 pharmacy outlets in Asmara between August and September, 2017. Two-stage
cluster sampling was employed and data were collected using a structured
questionnaire through face to face exit interviews. Descriptive statistics and
multivariate logistic regression were performed using SPSS (version 22).
RESULTS: Of the 609 customers, 93.7% had practiced self-medication with OTC
drugs; of which 81.8% were at risky practice. On average, each participant was
using OTC drugs at least once a month (Median = 1, IQR = 3.67). Educational level
(p < 0.0001), religion (p = 0.047), occupation (p = 0.027) and knowledge
regarding OTC drugs (p = 0.019) were significantly associated with risky
practice. Respondents with elementary and below educational level were fifteen
times (AOR = 15.49, CI: 1.97, 121.80) at higher risk compared to those with
higher education, and students were almost three times (AOR = 2.96, CI: 1.13,
7.73) at higher risk than governmental employees. Furthermore, respondents with
below average score in knowledge were more likely to be engaged in risky practice
(AOR = 1.83, CI: 1.11, 3.04) compared to those with above average score. The most
frequently preferred OTC drug group was analgesics (34.3%) followed by
antipyretics (15.7%) and cough and cold preparations (14.2%). About 14% of the
respondents admitted that they had taken more than the recommended dose and 6.9%
had experienced drug related problems following the consumption of OTC drugs.
Always, 35% of the respondents read package insert(s) and 73.9% check expiry
dates while purchasing OTC drugs. Refrigerating OTC drugs, where it is not
recommended, was also one of the prominent risky practices.
CONCLUSIONS: This study revealed that inappropriate self-medication practice with
OTC drugs was prevalent requiring early intervention to minimize the risks.
DOI: 10.1186/s12889-019-6470-5
PMCID: PMC6364400
PMID: 30727984 [Indexed for MEDLINE]
Author information:
(1)Department of Pathology, Brigham and Women's Hospital, Harvard Medical School,
Boston, MA.
Comment in
Fam Med. 2015 Jun;47(6):488-9.
Comment on
Fam Med. 2014 Nov-Dec;46(10):797-801.
Kuecuekbalaban P(1), Schmidt S(1), Beutel M(2), Weidner K(3), de Zwaan M(4),
Braehler E(2), Muehlan H(1).
Author information:
(1)Department Health and Prevention, Ernst-Moritz-Arndt-University Greifswald,
Greifswald, Germany.
(2)Department of Psychosomatic Medicine and Psychotherapy, University Medical
Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
(3)Clinic and Polyclinic for Psychiatry and Psychosomatics of the University of
Medical Centre Carl Gustav Carus of the Technical University of Dresden, Dresden,
Germany.
(4)Department of Psychosomatic and Psychotherapy of the Medical University of
Hannover, Hannover, Germany.
INTRODUCTION: A broad range of self-tests (testing for e.g. HIV, cancer,
hepatitis B/C) have become available and can be conducted by lay consumers
without the help of a health professional. The aims of this study were to (a)
investigate the prevalence of self-testing, (b) identify the most frequently used
self-tests, and (c) explore the associations between socio-demographic,
health-related and individual factors with self-testing.
METHODS: A face-to-face plus paper-pencil cross-sectional survey was conducted.
The sample consisted of 2.527 respondents who were representative of the German
population in terms of the age, sex, and residence. Basic descriptive statistics
and univariate logistic regression analyses were performed.
RESULTS: 8.5% of the participants reported having used one or more self-tests in
the past, totalling 363 self-tests, with a mean of 1.7 (min. = 1, max. = 6). The
three self-tests most frequently indicated were for detecting diabetes, bowel
cancer, and allergies. Self-testers were older (Nagelkerke R2 = .006, p < .01),
had a higher BMI (Nagelkerke R2 = .013, p < .001) and displayed more physical and
mental fatigue (Nagelkerke R2 = .031, p < .001) than non-testers. Self-testers
also reported higher global life satisfaction values (Nagelkerke R2 = .008, p <
.01) and a higher educational level (Nagelkerke R2 = .015, p < .01).
CONCLUSIONS: Self-testing is fairly prevalent in Germany Given the current
shortage of physicians in Germany, especially in rural areas, and recent studies
on the use of self-medication, the topic of self-testing has a great practical
and socio-political relevance. Future studies should investigate further
predictors of self-testing (e.g. contextual, situational and individual factors)
as well as the emotional consequences of testing as a layperson without the
attendance of a health professional.
DOI: 10.1371/journal.pone.0188653
PMCID: PMC5708746
PMID: 29190726 [Indexed for MEDLINE]
Haque M(1), Rahman NAA(2), McKimm J(3), Kibria GM(1), Azim Majumder MA(4), Haque
SZ(5), Islam MZ(6), Binti Abdullah SL(1), Daher AM(1), Zulkifli Z(7), Rahman
S(8), Kabir R(9), Lutfi SNNB(1), Aishah Binti Othman NS(1).
Author information:
(1)Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional
Malaysia (National Defence University of Malaysia), Kuala Lumpur, 57000,
Malaysia.
(2)Department of Physical Rehabilitation Sciences, Kulliyyah of Allied Health
Sciences, International Islamic University Malaysia, Kuantan, 25200, Malaysia.
(3)Swansea University School of Medicine, Grove Building, Swansea University,
Swansea, Wales, SA2 8PP, UK.
(4)Department of Medical Education, Faculty of Medical Sciences, The University
of the West Indies, Bridgetown, Barbados, West Indies.
(5)Department of Orthopedic Surgery, Ninewells Hospital & Medical School, Dundee,
DD1 9SY, Scotland, UK.
(6)Department of Pharmacology, Eastern Medical College, Burichang 3520,
Bangladesh.
(7)Department of Surgery, Sultan Haji Ahmad Shah Hospital, Temerloh, Pahang,
28000, Malaysia.
(8)Department of Pharmacology and Public Health, School of Medicine, American
University of Integrative Sciences, Bridgetown, Barbados.
(9)School of Allied Health, Faculty of Health, Education, Medicine and Social
Care, Anglia Ruskin University, Chelmsford, Essex, UK.
DOI: 10.2147/IDR.S203364
PMCID: PMC6529675
PMID: 31190922
Boyd CJ(1), Austic E(2), Epstein-Ngo Q(3), Veliz PT(2), McCabe SE(2).
Author information:
(1)School of Nursing, Addiction Research Center, University of Michigan.
(2)Addiction Research Center, University of Michigan.
(3)School of Nursing, Addiction Research Center, and Institute for Research on
Women and Gender, University of Michigan.
DOI: 10.1037/adb0000026
PMCID: PMC4388758
PMID: 25419966 [Indexed for MEDLINE]
Author information:
(1)Manipal College of Pharmaceutical Sciences, Manipal, India.
(2)MCOPS, Manipal University, Udupi, India.
(3)Manipal College of Pharmaceutical Sciences, Manipal University, Manipal,
India.
DOI: 10.1016/j.jval.2014.08.371
PMID: 27202890
Author information:
(1)FIFA-Medical Assessment and Research Center (F-MARC), Schulthess Clinic,
Zürich, Switzerland Division of Orthopedics and Trauma Surgery, Geneva University
Hospital, Switzerland.
(2)Fédération Internationale de Football Association, Zürich, Switzerland.
(3)FIFA-Medical Assessment and Research Center (F-MARC), Schulthess Clinic,
Zürich, Switzerland Fédération Internationale de Football Association, Zürich,
Switzerland.
The use of medication in international football has been monitored since the 2002
FIFA World Cup. Team physicians were asked to provide information on prescribed
medication 72 h prior to each match for every player. 69% of adult male players
reported using medication, with more than half the players using non-steroidal
anti-inflammatory drugs (NSAIDs). Up to one-third of all players used NSAIDs
prior to every match, regardless of whether they took the field or not. The mean
intake of medication was significantly higher during the FIFA Women's World Cup
(0.85 vs 0.77 substances per player and per match in men, p<0.001), whereas the
use of NSAIDs was similar to that for men. In the Under-20 and Under-17 male
competitions, the use of medication was lower as 60% of players used some kind of
medication and 43% of the players used NSAIDs during the tournaments. Despite the
potential side effects of medication, especially of NSAIDs in the recovery
process after a sports activity, there is no evidence of decreasing intake. The
reported incidence is alarming, and moreover is most probably underestimated,
since self-medication by the players or treatment already prescribed by club
physicians is not included in the published reports. Future studies should focus
on the daily dosage, time of treatment and especially the medical indication for
painkilling agents to better understand the underlying factors.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://group.bmj.com/group/rights-licensing/permissions.
DOI: 10.1136/bjsports-2015-094784
PMCID: PMC4413681
PMID: 25878074 [Indexed for MEDLINE]
Rehman MU(1), Mehsud SU(2), Ali S(3), Ishaq M(4), Khan MA(5).
Author information:
(1)Department of Pharmacology, IBMS-Khyber Medical University Peshawar, Pakistan.
(2)2Department of Pharmacy, Abbottabad University of Science and Technology
Abbottabad, Pakistan.
(3)Comsats Institute of Information and Technology, Abbottabad, Pakistan.
(4)Department of Community Medicine, Saidu Medical College, Saidu Sharif Swat,
Pakistan.
(5)Epidemeologic Cell, NIH, Islamabad, Pakistan.
BACKGROUND: Common cold and flu are mostly of viral pathogenesis with symptoms in
upper respiratory tract. It is highly contagious and close inter-individual
contact in winter season increase the spread spectrum. Mis-interpretation with
bacterial cause leads to irrationality in its medication.
METHODS: A cross-sectional study was conducted among pharmacy department students
in February-March 2016. Data were collected through self-administered
questionnaire and expressed as percentage frequency.
RESULTS: Total 180 students were provided with questionnaire to fill the desired
data. 66 out of them were reported as patients of common cold and flu. Trend of
medication after compilation and analyzing data reveal that: 60.60% (n=40/66)
students got irrational medication, 4.54% (n=3/66) students presents with other
disease, so were declared of complex nature and 9.1% (n=6/66) patients, presented
only with symptoms were counseled accordingly to the standard therapy by Health
Protection Agency-UK (Management of infection guidance for primary care for
consultation and local adaptation, 2013), and Columbia University Medical Center
(Guidelines for the empiric use of antibiotics in adult patients - Feb, 2005) and
all of them were followed for their entire therapy time. All of the counseled
patients recovered successfully. Total 25.76% (n=17/66) other than that of
counseled group students also got rational medication.
CONCLUSIONS: Use of medicine by students in study was found irrational. National
and international awareness programs about such viral disease should be designed
and arranged to promote information in the community and limit the irrational
medication. It also need an active health regulatory authority in undeveloped and
less developed countries specially to limit the availability of prescription
drugs without physician advise through availability of qualified person in
pharmacies.
Medication use among children 0-14 years old: population baseline study.
Cruz MJ(1), Dourado LF(2), Bodevan EC(3), Andrade RA(2), Santos DF(2).
Author information:
(1)Faculdade de Ciências Biológicas e da Saúde, Universidade Federal dos Vales do
Jequitinhonha e Mucuri (UFVJM), Diamantina, MG, Brazil. Electronic address:
maria_enfermagem@yahoo.com.br.
(2)Faculdade de Ciências Biológicas e da Saúde, Universidade Federal dos Vales do
Jequitinhonha e Mucuri (UFVJM), Diamantina, MG, Brazil.
(3)Faculdade de Ciências Exatas e Tecnológicas, Universidade Federal dos Vales do
Jequitinhonha e Mucuri (UFVJM), Diamantina, MG, Brazil.
DOI: 10.1016/j.jped.2014.03.004
PMID: 24953722 [Indexed for MEDLINE]
Author information:
(1)Dow University of Health Sciences, Karachi, Pakistan.
DOI: 10.1186/s13690-015-0113-9
PMCID: PMC4722669
PMID: 26807216
Author information:
(1)Centre for Clinical Pharmacology, University Clinical Hospital Mostar, Mostar,
Bosnia and Herzegovina.
(2)Department of Family Medicine, University of Split School of Medicine, Split.
(3)Family Medicine Clinic, Health Centre Imotski, Kamenmost.
(4)Laboratory for Pain Research, University of Split School of Medicine, Split,
Croatia.
DOI: 10.2147/JPR.S123554
PMCID: PMC5315341
PMID: 28243140
201. Life Sci. 2014 Oct 2;114(2):86-92. doi: 10.1016/j.lfs.2014.08.005. Epub 2014
Aug
14.
Lacy RT(1), Strickland JC(1), Brophy MK(1), Witte MA(1), Smith MA(2).
Author information:
(1)Department of Psychology, Davidson College, USA.
(2)Department of Psychology, Davidson College, USA; Program in Neuroscience,
Davidson College, USA. Electronic address: masmith@davidson.edu.
AIMS: Epidemiological studies report that individuals who exercise are less
likely to abuse drugs. Preclinical studies report that exercise, in the form of
treadmill or wheel running, reliably decreases the self-administration of
psychomotor stimulants and opioids. To date, preclinical studies have only
examined the effects of exercise on responding maintained by individual drugs and
not by combinations of multiple drugs. This limits the translational appeal of
these studies because polydrug abuse is common among substance abusing
populations. The purpose of this study was to examine the effects of exercise on
the self-administration of speedball, a combination of cocaine and heroin that is
frequently encountered in intravenous drug abusing populations.
MAIN METHODS: Female rats were obtained at weaning and assigned to sedentary or
exercising conditions. Sedentary rats were housed in standard cages that
permitted no exercise beyond normal cage ambulation; exercising rats were housed
in similar cages with an activity wheel. After 6weeks, rats were implanted with
intravenous catheters and trained to self-administer cocaine, heroin, and dose
combinations of cocaine and heroin (i.e., speedball) on a progressive ratio
schedule of reinforcement.
KEY FINDINGS: Doses of speedball maintained greater levels of responding than
corresponding doses of cocaine and heroin alone. Importantly, responding
maintained by cocaine, heroin, and speedball was lower in exercising rats than
sedentary rats.
SIGNIFICANCE: These data indicate that exercise decreases the self-administration
of speedball and suggest that exercise may reduce the abuse of drug combinations
that have traditionally been resistant to treatment.
DOI: 10.1016/j.lfs.2014.08.005
PMCID: PMC4175302
PMID: 25132360 [Indexed for MEDLINE]
Author information:
(1)Faculty of Medicine, University of Niš, Zorana Đinđića 81, 18000 Niš, Serbia.
(2)Clinic for Mental Health, Clinical Center Niš, 18000 Niš, Serbia.
(3)Department of Physiology, Faculty of Medicine, University of Niš, Zorana
Đinđića 81, 18000 Niš, Serbia.
(4)Clinic for Psychiatry ''Gornja Toponica'', Clinical Center Niš, 18000 Niš,
Serbia.
(5)Department of Chemistry, Faculty of Sciences and Mathematics, University of
Niš, Višegradska 33, 18000 Niš, Serbia.
DOI: 10.1016/j.jsps.2018.01.009
PMCID: PMC5856938
PMID: 29556124
Author information:
(1)Medical Faculty, Vilnius University, Vilnius, Lithuania.
(2)Department of Pathology, Forensic Medicine and Pharmacology, Medical Faculty,
Vilnius University, Lithuania.
(3)Centre of Anaesthesiology, Intensive Care and Pain Management, Vilnius
University Hospital Santariškių Klinikos, Vilnius, Lithuania.
204. Integr Pharm Res Pract. 2016 Dec 19;6:1-6. doi: 10.2147/IPRP.S103494.
eCollection
2017.
Author information:
(1)Pharmaceutical Health Outcomes and Policy, College of Pharmacy, University of
Houston, Houston, TX, USA.
DOI: 10.2147/IPRP.S103494
PMCID: PMC5774309
PMID: 29354545
Author information:
(1)Department of Family and Preventive Medicine, University of Utah.
Comment on
Fam Med. 2014 Nov-Dec;46(10):797-801.
Fam Med. 2015 Jun;47(6):487-8.
Abelman DD(1).
Author information:
(1)School of Health Studies, Faculty of Health Sciences, Western University,
London, ON, N6A 5B9, Canada. dabelman@uwo.ca.
DOI: 10.1186/s12954-017-0194-6
PMCID: PMC5639593
PMID: 28985738 [Indexed for MEDLINE]
Author information:
(1)Associate Professor, Department of Obstetrics and Gynecology, Sri
Manakulavinayagar Medical College Hospital , Kalitheerthalkuppam, Puducherry,
India .
(2)Professor, Department of Obstetrics and Gynecology, Sri Manakulavinayagar
Medical College Hospital , Kalitheerthalkuppam, Puducherry, India .
DOI: 10.7860/JCDR/2015/11626.5388
PMCID: PMC4347129
PMID: 25738038
Author information:
(1)Department of Psychiatry, Government Medical College, Thiruvananthapuram,
Kerala, India.
(2)Department of Psychiatry, Dr. Kunhalu's Nursing Home, Ernakulam, Kerala,
India.
(3)Department of Psychiatry, General Hospital, Ernakulam, Kerala, India.
DOI: 10.4103/jfmpc.jfmpc_206_17
PMCID: PMC5848416
PMID: 29564281
Shurkin J.
DOI: 10.1073/pnas.1419966111
PMCID: PMC4267359
PMID: 25492915 [Indexed for MEDLINE]
Comment on "Is It Safe to Provide Abortion Pills Over The Counter? A Study on
Outcome Following Self-Medication with Abortion Pills".
Author information:
(1)Program Associate, Gynuity Health Projects , New York, NY 10010 US .
(2)President, Gynuity Health Projects , New York, NY 10010 US .
DOI: 10.7860/JCDR/2015/14291.6380
PMCID: PMC4576599
PMID: 26436006
Predictors of New Onset Sleep Medication and Treatment Utilization Among Older
Adults in the United States.
Author information:
(1)Department of Psychiatry, University of Michigan, Ann Arbor.
leggetta@med.umich.edu.
(2)Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
(3)Institute for Social Research, University of Michigan, Ann Arbor.
(4)Department of Psychiatry and Center for Ethnicity, Culture, and Health, School
of Public Health, University of Michigan, Ann Arbor.
DOI: 10.1093/gerona/glv227
PMCID: PMC4906325
PMID: 26755681 [Indexed for MEDLINE]
212. Infect Drug Resist. 2019 Jun 11;12:1617. doi: 10.2147/IDR.S218283. eCollection
2019.
DOI: 10.2147/IDR.S218283
PMCID: PMC6576122
PMID: 31354310
'I take my tablets with the whiskey': A qualitative study of alcohol and
medication use in mid to later life.
Haighton C(1)(2), Kidd J(2), O'Donnell A(2), Wilson G(2)(3), McCabe K(4), Ling
J(4).
Author information:
(1)Department of Social Work, Education and Community Wellbeing, Northumbria
University, Newcastle upon Tyne, United Kingdom.
(2)Institute of Health and Society, Newcastle University, Newcastle upon Tyne,
United Kingdom.
(3)Reid School of Music, University of Edinburgh, Edinburgh, United Kingdom.
(4)School of Nursing and Health Sciences, University of Sunderland, Sunderland,
United Kingdom.
DOI: 10.1371/journal.pone.0205956
PMCID: PMC6193697
PMID: 30335835 [Indexed for MEDLINE]
Conflict of interest statement: CH serves on the PLOS ONE Editorial Board. This
does not alter our adherence to all the PLOS ONE policies on sharing data and
materials.
Elong Ekambi GA(1), Okalla Ebongue C(2), Penda IC(3), Nnanga Nga E(1), Mpondo
Mpondo E(1), Eboumbou Moukoko CE(2)(4).
Author information:
(1)Pharmaceutical Sciences Department, Faculty of Medicine and Pharmaceutical
Sciences, University of Douala, Douala, Cameroon.
(2)Biological Sciences Department, Faculty of Medicine and Pharmaceutical
Sciences, University of Douala, Douala, Cameroon.
(3)Clinical Sciences Department, Faculty of Medicine and Pharmaceutical Sciences,
University of Douala, Douala, Cameroon.
(4)Centre Pasteur Cameroon, Yaoundé, Cameroon.
DOI: 10.1371/journal.pone.0212875
PMCID: PMC6394986
PMID: 30818373
Author information:
(1)House Officer, Obstetrics & Gynaecology, Isra University Hospital, Hyderabad
Sindh, Pakistan.
(2)Department of Obstetrics & Gynaecology, Isra University Hospital, Hyderabad
Sindh, Pakistan.
Author information:
(1)Institute of Neuroscience, Medical School, Newcastle University, Newcastle,
United Kingdom.
DOI: 10.2174/1570159X15666170915142122
PMCID: PMC6018185
PMID: 28925882 [Indexed for MEDLINE]
Author information:
(1)1 Department of Psychiatry, University of Colorado Anschutz Medical Campus,
Aurora, CO, USA.
(2)2 Research Service, Denver VA Medical Center, Denver, CO, USA.
DOI: 10.1177/0269881117705071
PMCID: PMC5963521
PMID: 28441884 [Indexed for MEDLINE]
Alzahrani M(1), Alhindi T(2), Almutairi A(2), Aldajani M(2), Sami W(3).
Author information:
(1)Department of Family Medicine, College of Medicine, Majmaah University,
Kingdom of Saudi Arabia.
(2)Medical Student, College of Medicine, Majmaah University, Kingdom of Saudi
Arabia.
(3)Department of Public Health & Community Medicine, College of Medicine, Majmaah
University, Kingdom of Saudi Arabia.
Author information:
(1)Department of Psychiatry, Charles University First Faculty of Medicine and
General Teaching Hospital, Center for Cognitive Molecular Neuroscience, Prague,
Czech Republic.
(2)Warsaw Medical University, Public Central Teaching Hospital, Warsaw, Poland.
Over the course of human history, it has been common to use plants for medicinal
purposes, such as for providing relief from particular maladies and
self-medication. Opium represents one longstanding remedy that has been used to
address a range of medical conditions, alleviating discomfort often in ways that
have proven pleasurable. Opium is a combination of compounds obtained from the
mature fruit of opium poppy, papaver somniferum. Morphine and its biosynthetic
precursors thebaine and codeine constitute the main bioactive opiate alkaloids
contained in opium. Opium usage in ancient cultures is well documented, as is its
major extract morphine. The presence of endogenous opiate alkaloids and opioid
peptides in animals owe their discovery to their consistent actions at particular
concentrations via stereo select receptors. In vitro expression of morphine
within a microbiological industrial setting underscores the role it plays as a
multi-purpose pharmacological agent, as well as reinforcing why it can also lead
to long-term social dependence. Furthermore, it clearly establishes a reciprocal
effect of human intelligence on modifying evolutionary processes in papaver
somniferum and related plant species.
DOI: 10.12659/msm.905167
PMCID: PMC5478244
PMID: 28609429 [Indexed for MEDLINE]
Author information:
(1)Department of Clinical Sciences, Faculty of Medicine and Pharmaceutical
Sciences, University of Douala, Douala, Cameroon.
(2)Department of Pediatrics, Laquintinie Hospital of Douala, Cameroon.
(3)Department of Biological Sciences, Faculty of Medicine and Pharmaceutical
Sciences, University of Douala, Cameroon.
(4)Malaria Research Service, Centre Pasteur Cameroon, Yaoundé, Cameroon.
(5)Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmaceutical
Sciences, University of Douala, Cameroon.
DOI: 10.11604/pamj.2018.30.302.16321
PMCID: PMC6320450
PMID: 30637086 [Indexed for MEDLINE]
Association of Self-Care Behaviors and Quality of Life among Patients with Type 2
Diabetes Mellitus: Chaldoran County, Iran.
Babazadeh T(1), Dianatinasab M(2), Daemi A(3), Nikbakht HA(4), Moradi F(5),
Ghaffari-Fam S(6).
Author information:
(1)PhD Candidate in Health Education and Promotion, Student Research Committee,
Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.
(2)Shiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of
Medical Sciences, Shiraz, Iran. dianatinasab@sums.ac.ir.
(3)Health Management and Economics Research Center, Iran University of Medical
Sciences, Tehran, Iran.
(4)Social Determinants of Health Research Center, Babol University of Medical
Sciences, Babol, Iran.
(5)Department of Municipal Health in Tehran, Tehran Municipality, Tehran, Iran.
(6)School of Nursing of Miyandoab, Urmia University of Medical Sciences, Urmia,
Iran. ghaffari.sa@tak.iums.ac.ir.
222. Trop Med Int Health. 2017 May;22(5):638-654. doi: 10.1111/tmi.12865. Epub 2017
Apr 11.
Author information:
(1)School of Public Health, Peking University, Beijing, China.
DOI: 10.1111/tmi.12865
PMID: 28278358 [Indexed for MEDLINE]
223. BMC Health Serv Res. 2018 May 10;18(1):346. doi: 10.1186/s12913-018-3146-2.
Deane KHO(1), Gray R(1)(2), Balls P(3), Darrah C(3), Swift L(4), Clark AB(4),
Barton GR(4), Morris S(4), Butters S(3), Bullough A(3), Flaherty H(1)(5), Talbot
B(6), Sanders M(3), Donell ST(7)(8).
Author information:
(1)School of Health Sciences, University of East Anglia, Norwich Research Park,
Norwich, UK.
(2)Present address: School of Nursing and Midwifery, Latrobe University,
Melbourne, Australia.
(3)Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK.
(4)Norwich Medical School, Norwich Clinical Trials Unit, University of East
Anglia, Norwich, UK.
(5)Present address: School of Clinical & Applied Sciences, Leeds Beckett
University, Leeds, UK.
(6)Public & Patient Involvement in Research (PPIRes), South Norfolk Clinical
Commissioning Group, Norwich, UK.
(7)Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK.
s.donell@uea.ac.uk.
(8)Norwich Medical School, University of East Anglia, Norwich, UK.
s.donell@uea.ac.uk.
DOI: 10.1186/s12913-018-3146-2
PMCID: PMC5944138
PMID: 29743064 [Indexed for MEDLINE]
224. Risk Manag Healthc Policy. 2019 Jan 15;12:1-3. doi: 10.2147/RMHP.S190514.
eCollection 2019.
Author information:
(1)Faculty of Medicine, St George's, University of London, London, UK,
waqarsyed458@gmail.com.
Comment on
Risk Manag Healthc Policy. 2018 Sep 12;11:169-176.
DOI: 10.2147/RMHP.S190514
PMCID: PMC6339650
PMID: 30697091
Ouedraogo AS(1), Jean Pierre H(2), Bañuls AL(3), Ouédraogo R(1), Godreuil S(4).
Author information:
(1)Service de bactériologie-virologie, CHU de Souro Sanou, Bobo Dioulasso,
Burkina Faso.
(2)Laboratoire de bactériologie-virologie, CHU de Montpellier, 34295 Montpellier
cedex 5, France.
(3)Mivegec, UMR IRD 224, CNRS 5290, Université de Montpellier, Montpellier,
France.
(4)Laboratoire de bactériologie-virologie, CHU de Montpellier, 34295 Montpellier
cedex 5, France, Mivegec, UMR IRD 224, CNRS 5290, Université de Montpellier,
Montpellier, France.
The emergence and spread of antibiotic resistance present a major public health
issue in both developed (DC) and less developed countries (LDC). Worldwide, its
main cause is the uncontrolled and unjustified use of antibiotics. In countries
with limited resources, such as West African nations, other features, more
specifically socioeconomic and behavioral factors, contribute to exacerbate this
problem. The objective of this review is to give an update of the common and
specific factors involved in the amplification of antibiotic resistance phenomena
in LCD, particularly in West African countries. In particular, some frequent
societal behaviors (such as self-medication), inadequate healthcare
infrastructure (insufficiently trained prescribers and inadequate diagnostic
tools), and an uncontrolled drug sector (antibiotics sold over-the-counter,
improperly stored, counterfeit, and/or expired) all strongly promote the
emergence of antibiotic resistance. This risk is particularly worrisome for
enterobacteriaceae producing extended spectrum beta-lactamases (10 to 100 % of
colonizations and 30 to 50 % of infections). A similar trend has been observed
for carbapenem resistance in enterobacteriaceae with rates ranging from 10 to
30 % and for methicillin resistance in Staphylococcus aureus, which now exceeds
30 %. These troubling observations call for effective health policies in these
regions. These intervention strategies must be integrated and simultaneously
target policy makers, prescribers, and users.
DOI: 10.1684/mst.2017.0678
PMID: 28655675 [Indexed for MEDLINE]
226. Patient Prefer Adherence. 2016 Jun 27;10:1161-7. doi: 10.2147/PPA.S105600.
eCollection 2016.
Author information:
(1)Department of Clinical Pharmacy, School of Basic Medical Sciences and Clinical
Pharmacy, China Pharmaceutical University.
(2)Institute of Cardiovascular Disease, Southeast University Medical School,
Nanjing, People's Republic of China.
Erratum in
Patient Prefer Adherence. 2016;10:1697.
PURPOSE: The objective of this study was to identify, using the theory of planned
behavior (TPB), patients' beliefs about taking oral antidiabetic drugs (OADs) as
prescribed, and to measure the correlations between beliefs and medication
adherence.
PATIENTS AND METHODS: We performed a cross-sectional study of type 2 diabetic
patients using structured questionnaires in a Chinese tertiary hospital. A total
of 130 patients were enrolled to be interviewed about TPB variables (behavioral,
normative, and control beliefs) relevant to medication adherence. Medication
adherence was assessed using the eight-item Morisky Medication Adherence Scale
(MMAS-8). Spearman's rank correlation was used to assess the association between
TPB and MMAS-8. Logistic regression analysis was performed to examine the
relationship between different variables and MMAS-8, with statistical
significance determined at P<0.05.
RESULTS: From 130 eligible Chinese patients with an average age of 60.6 years and
a male proportion of 50.8%, a nonsignificant relationship between behavioral,
normative, and the most facilitating control beliefs and OAD adherence was found
in our study. Having the OADs on hand (P=0.037) was the only facilitating control
belief associated with adherence behavior. Being away from home or eating out
(P=0.000), not accepting the disease (P=0.000), ignorance of life-long drug
adherence (P=0.038), being busy (P=0.001), or poor memory (P=0.008) were control
belief barriers found to be correlated with poor adherence. TPB is the only
important determinant influencing OAD adherence among all the factors (P=0.011).
CONCLUSION: The results indicate that the TPB model could be used to examine
adherence to OADs. One facilitating control belief, and most of the barrier
control beliefs of TPB were related to medication adherence among Chinese type 2
diabetes inpatients. It will be helpful to understand patients' self-medication
and provide methods to develop instruments for identifying factors that influence
OAD adherence.
DOI: 10.2147/PPA.S105600
PMCID: PMC4930230
PMID: 27390519
227. Am J Drug Alcohol Abuse. 2016 Sep;42(5):500-506. Epub 2016 Jul 11.
DOI: 10.1080/00952990.2016.1192639
PMCID: PMC5055455
PMID: 27398730 [Indexed for MEDLINE]
Author information:
(1)Department of Social Work, Malmö University, Malmo, Sweden.
torkel.richert@mah.se.
(2)Department of Social Work, Malmö University, Malmo, Sweden.
bjorn.johnson@mah.se.
DOI: 10.1186/s12954-015-0037-2
PMCID: PMC4337060
PMID: 25889208 [Indexed for MEDLINE]
AlAzmi A(1), AlHamdan H(1), Abualezz R(2), Bahadig F(1), Abonofal N(1), Osman
M(1).
Author information:
(1)Ministry of National Guard Health Affairs (MNGHA), King Abdulaziz Medical City
(KAMC 6255), Pharmaceutical Care Services Department, P.O. Box 9515, Jeddah
21423, Saudi Arabia.
(2)Ministry of National Guard Health Affairs (MNGHA), Prince Mohamed Bin
Abdulaziz Hospital, Pharmaceutical Care Services Department, P.O. Box 40740,
Madinah 41511, Saudi Arabia.
DOI: 10.1155/2017/8516741
PMCID: PMC5654249
PMID: 29130019
Author information:
(1)1 University of Duisburg-Essen, Essen, Germany.
DOI: 10.1177/2156587216671392
PMCID: PMC5871155
PMID: 27707902 [Indexed for MEDLINE]
Foltin RW(1).
Author information:
(1)Division on Substance Use Disorders, New York State Psychiatric Institute and
Department of Psychiatry, Columbia University Medical Center, 1051 Riverside
Drive, Unit 120, New York, NY 10032, USA. Electronic address:
rwf2@cumc.columbia.edu.
DOI: 10.1016/j.pbb.2018.03.005
PMCID: PMC5892839
PMID: 29545026 [Indexed for MEDLINE]
El-Hawy RM(1), Ashmawy MI(1), Kamal MM(1), Khamis HA(2), Abo El-Hamed NM(3),
Eladely GI(4), Abdo MH(4), Hashem Y(1), Ramadan M(4), Hamdy DA(1).
Author information:
(1)Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
(2)Faculty of Science, Alexandria University, Alexandria, Egypt.
(3)Faculty of Agriculture, Alexandria University, Alexandria, Egypt.
(4)Faculty of Medicine, Alexandria University, Alexandria, Egypt.
DOI: 10.1136/ejhpharm-2016-001032
PMCID: PMC6451550
PMID: 31156970
Author information:
(1)Department of Psychosis Studies, Institute of Psychiatry, Psychology and
Neuroscience, Kings College London, SE5 8AF, Denmark Hill, London, UK.
(2)Department of Psychosis Studies, Institute of Psychiatry, Psychology and
Neuroscience, Kings College London, London, UK.
DOI: 10.1177/2045125319859969
PMCID: PMC6604123
PMID: 31308936
Eaves ER(1).
Author information:
(1)Department of Family and Community Medicine, University of Arizona College of
Medicine, USA. Electronic address: emerye@email.arizona.edu.
DOI: 10.1016/j.socscimed.2015.10.033
PMCID: PMC4643358
PMID: 26517291 [Indexed for MEDLINE]
Episodic oral antibiotic use in CF: Discordance between the electronic medical
record and self-report.
Caverly LJ(1), Caverly TJ(2), Kalikin LM(3), Foster BK(3), Simon RH(4), LiPuma
JJ(3).
Author information:
(1)Department of Pediatrics and Communicable Diseases, University of Michigan
Medical School, Ann Arbor, MI 48109, United States. Electronic address:
caverlyl@med.umich.edu.
(2)Department of Internal Medicine, University of Michigan Medical School, Ann
Arbor, MI 48109, United States; Center for Clinical Management Research, Veterans
Affairs, Ann Arbor, MI 48105, United States.
(3)Department of Pediatrics and Communicable Diseases, University of Michigan
Medical School, Ann Arbor, MI 48109, United States.
(4)Department of Internal Medicine, University of Michigan Medical School, Ann
Arbor, MI 48109, United States.
Copyright © 2016 European Cystic Fibrosis Society. Published by Elsevier B.V. All
rights reserved.
DOI: 10.1016/j.jcf.2016.04.009
PMCID: PMC5014681
PMID: 27156045 [Indexed for MEDLINE]
Author information:
(1)Department of Psychiatry, University Hospital Centre Zagreb, Kispaticeva 12,
10 000 Zagreb, Croatia, marinasagud@mail.com.
Patients with schizophrenia continue to have the highest rate of both smoking and
heavy nicotine dependence. The interaction between smoking and schizophrenia is
complex. There is evidence of the shared genetic background. Recent preclinical
and clinical research has further investigated self-medication hypothesis, given
that nicotine might alleviate cortical dysfunction. While prior research
indicated some favorable effects of smoking on cognitive performance,
particulatly on attention/vigilance, recent studies did not confirm those
findings. Lower severity of negative symptoms in smokers was not confirmed across
studies. Cigarette smoking decreases clozapine and olanzapine concentrations.
There is no consistent evidence of favorable effects of nicotine on symptoms in
schizophrenia, but the evidence of detrimental effects of smoking on general
health is highly consistent. Smoking cessation should be a priority in patients
with schizophrenia.
Wu J(1), Ginsberg JS(1), Zhan M(2), Diamantidis CJ(1), Chen J(1), Woods C(3),
Fink JC(4).
Author information:
(1)Departments of Medicine and.
(2)Epidemiology and Public Health, School of Medicine, University of Maryland,
Baltimore, Maryland; and.
(3)Department of Pharmaceutical Health Services Research, School of Pharmacy,
University of Maryland, Baltimore.
(4)Departments of Medicine and jfink@medicine.umaryland.edu.
Comment in
Clin J Am Soc Nephrol. 2015 Mar 6;10(3):350-2.
DOI: 10.2215/CJN.06520714
PMCID: PMC4348685
PMID: 25710806 [Indexed for MEDLINE]
Author information:
(1)Programa de Pós-Graduação em Epidemiologia. Universidade Federal de Pelotas.
Pelotas, RS, Brasil.
(2)Departamento de Medicina Social. Faculdade de Medicina. Universidade Federal
de Pelotas. Pelotas, RS, Brasil.
DOI: 10.1590/S1518-8787.2017051006556
PMCID: PMC5493363
PMID: 28658367 [Indexed for MEDLINE]
239. Ann N Y Acad Sci. 2017 Apr;1394(1):92-105. doi: 10.1111/nyas.13276. Epub 2016
Dec
9.
Utility of preclinical drug versus food choice procedures to evaluate candidate
medications for methamphetamine use disorder.
Banks ML(1).
Author information:
(1)Department of Pharmacology and Toxicology, Virginia Commonwealth University,
Richmond, Virginia.
DOI: 10.1111/nyas.13276
PMCID: PMC5423852
PMID: 27936284 [Indexed for MEDLINE]
240. Yale J Biol Med. 2015 Sep 3;88(3):247-56. eCollection 2015 Sep.
Weaver MF(1).
Author information:
(1)Department of Psychiatry and Behavioral Sciences, University of Texas Medical
School at Houston, Houston, Texas.
PMCID: PMC4553644
PMID: 26339207 [Indexed for MEDLINE]
Author information:
(1)Department of Psychology and Neuroscience, University of Colorado, Boulder,
Colorado 80309, and Department of Psychology and Neuroscience, University of
North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
michael.saddoris@colorado.edu.
(2)Department of Psychology and Neuroscience, University of North Carolina at
Chapel Hill, Chapel Hill, North Carolina 27599.
242. J Cutan Pathol. 2016 Jun;43(6):492-7. doi: 10.1111/cup.12705. Epub 2016 Apr 7.
Zhao G(1), Lee KC(2), Kwon G(1), Frederick PD(3), Onega TL(4)(5)(6), Piepkorn
MW(1)(7), Knezevich S(8), Barnhill RL(9)(10), Elder DE(11), Elmore JG(3).
Author information:
(1)Division of Dermatology, Department of Medicine, University of Washington
School of Medicine, Seattle, WA, USA.
(2)Department of Dermatology, Massachusetts General Hospital, Harvard University,
Boston, MA, USA.
(3)Department of Medicine, University of Washington School of Medicine, Seattle,
WA, USA.
(4)Department of Biomedical Data Science, Norris Cotton Cancer Center, Lebanon,
NH, USA.
(5)Department of Epidemiology, Norris Cotton Cancer Center, Lebanon, NH, USA.
(6)Department of Community and Family Medicine, Geisel School of Medicine at
Dartmouth, The Dartmouth Institute for Health Policy and Clinical Practice,
Lebanon, NH, USA.
(7)Dermatopathology Northwest, Bellevue, WA, USA.
(8)Pathology Associates, Clovis, CA, USA.
(9)Department of Pathology, Faculty of Medicine, University of Paris Descartes,
Paris, France.
(10)Institut Curie, Paris, France.
(11)Department of Pathology, University of Pennsylvania, Philadelphia, PA, USA.
Comment in
J Cutan Pathol. 2017 Jun;44(6):599-600.
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
DOI: 10.1111/cup.12705
PMCID: PMC5592970
PMID: 26968847 [Indexed for MEDLINE]
Author information:
(1)Aging & Metabolism Research Program, Oklahoma Medical Research Foundation,
Oklahoma City, OK.
(2)Department of Cellular and Integrative Physiology, University of Texas Health,
San Antonio, Texas.
(3)Department of Pharmaceutical Sciences, Feik School of Pharmacy, University of
the Incarnate Word, San Antonio, Texas.
(4)College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma
City, OK.
DOI: 10.1093/ijnp/pyx117
PMCID: PMC5888879
PMID: 29272412 [Indexed for MEDLINE]
244. Front Pharmacol. 2017 Nov 21;8:841. doi: 10.3389/fphar.2017.00841. eCollection
2017.
Traditional and Current Food Use of Wild Plants Listed in the Russian
Pharmacopoeia.
Shikov AN(1), Tsitsilin AN(2), Pozharitskaya ON(1), Makarov VG(1), Heinrich M(3).
Author information:
(1)Saint-Petersburg Institute of Pharmacy, Kuzmolovsky, Russia.
(2)All Russian Research Institute Medicinal and Aromatic Plants (VILAR), Moscow,
Russia.
(3)Research Cluster Biodiversity and Medicines, Centre for Pharmacognosy and
Phytotherapy, UCL School of Pharmacy, University of London, London, United
Kingdom.
DOI: 10.3389/fphar.2017.00841
PMCID: PMC5702350
PMID: 29209213
Coping with mental health issues: subjective experiences of self-help and helpful
contextual factors at the start of mental health treatment.
Biringer E(1)(2), Davidson L(3), Sundfør B(2), Lier HØ(1), Borg M(2)(4).
Author information:
(1)a Helse Fonna Local Health Authority , Haugesund , Norway .
(2)b Regional Research Network on Mood Disorders (MoodNet) , Bergen , Norway .
(3)c Department of Psychiatry , Yale University School of Medicine , New Haven ,
CT , USA , and.
(4)d Faculty of Health Sciences , Buskerud and Vestfold University College ,
Drammen , Norway.
DOI: 10.3109/09638237.2015.1078883
PMCID: PMC4776697
PMID: 26484831 [Indexed for MEDLINE]
DOI: 10.17236/sat00042
PMID: 26898026 [Indexed for MEDLINE]
247. Evol Appl. 2017 May 20;10(7):651-657. doi: 10.1111/eva.12465. eCollection 2017
Aug.
Thomas F(1), Rome S(2), Mery F(3), Dawson E(3), Montagne J(4), Biro PA(5),
Beckmann C(5), Renaud F(1), Poulin R(6), Raymond M(7), Ujvari B(5).
Author information:
(1)CREEC/MIVEGEC UMR IRD/CNRS/UM 5290 Montpellier Cedex 5 France.
(2)CarMen (UMR INSERM 1060, INRA 1397, INSA) Faculté de Médecine Lyon-Sud
Université de Lyon Oullins France.
(3)Evolution, Génomes, Comportement and Ecologie CNRS, IRD Université Paris-Sud,
Université Paris-Saclay Gif-sur-Yvette France.
(4)Institute for Integrative Biology of the Cell (I2BC) CNRS Université
Paris-Sud, CEA, UMR 9198 Gif-sur-Yvette France.
(5)Centre for Integrative Ecology School of Life and Environmental Sciences
Deakin University Waurn Ponds VIC Australia.
(6)Department of Zoology University of Otago Dunedin New Zealand.
(7)Institute of Evolutionary Sciences University of Montpellier Montpellier
France.
Changes in diet are frequently correlated with the occurrence and progression of
malignant tumors (i.e., cancer) in both humans and other animals, but an
integrated conceptual framework to interpret these changes still needs to be
developed. Our aim is to provide a new perspective on dietary changes in
tumor-bearing individuals by adapting concepts from parasitology. Dietary changes
may occur alongside tumor progression for several reasons: (i) as a pathological
side effect with no adaptive value, (ii) as the result of self-medication by the
host to eradicate the tumor and/or to slow down its progression, (iii) as a
result of host manipulation by the tumor that benefits its progression, and
finally (iv) as a host tolerance strategy, to alleviate and repair damages caused
by tumor progression. Surprisingly, this tolerance strategy can be beneficial for
the host even if diet changes are beneficial to tumor progression, provided that
cancer-induced death occurs sufficiently late (i.e., when natural selection is
weak). We argue that more data and a unifying evolutionary framework, especially
during the early stages of tumorigenesis, are needed to understand the links
between changes in diet and tumor progression. We argue that a focus on dietary
changes accompanying tumor progression can offer novel preventive and therapeutic
strategies against cancer.
DOI: 10.1111/eva.12465
PMCID: PMC5511355
PMID: 28717385
Introduction to Special Issue: At the Precipice of Quality Health Care: The Role
of the Toxicologist in Enhancing Patient and Medication Safety : At the Precipice
of Quality Health Care: The Role of the Toxicologist in Enhancing Patient and
Medication Safety. Venue: 2014 North American Congress of Clinical Toxicology.
ACMT Pre-Meeting Symposium, New Orleans, LA.
Author information:
(1)Division of Emergency Medicine, Weill-Cornell Medical Center, 525 E 68th St.,
M-130, New York, NY, 10065, USA, bmf9001@med.cornell.edu.
DOI: 10.1007/s13181-015-0473-0
PMCID: PMC4469724
PMID: 25840932 [Indexed for MEDLINE]
The expected and unexpected benefits of dispensing the exact number of pills.
Author information:
(1)Département AMSE, Aix-Marseille Université, CNRS, EHESS and Centrale,
Marseille, France.
(2)SESSTIM, Sciences Economiques & Sociales de la Santé et Traitement de
l'Information Médicale, Aix Marseille Université, INSERM, IRD, Marseille, France.
(3)ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur,
Marseille, France.
DOI: 10.1371/journal.pone.0184420
PMCID: PMC5604959
PMID: 28926636 [Indexed for MEDLINE]
Author information:
(1)Hemostasis and Thrombosis Center, Children's Hospital Los Angeles, University
of Southern California Keck School of Medicine, Los Angeles, California.
(2)University of Texas Health Science Center and the Gulf States Hemophilia and
Thrombophilia Center, Houston, Texas.
(3)Hemophilia and Coagulation Disorders Program, University of Michigan, Ann
Arbor, Michigan.
(4)Clinical, Medical and Regulatory Affairs, Novo Nordisk Inc, Plainsboro, New
Jersey.
DOI: 10.1002/ajh.24811
PMID: 28589615 [Indexed for MEDLINE]
Author information:
(1)a School of Pharmacy, Faculty of Health Sciences , University of Namibia ,
Windhoek , Namibia.
(2)b School of Public Health , Makerere University Kampala-Uganda , Kampala ,
Uganda.
(3)c Department of Pharmacoepidemiology , Strathclyde Institute of Pharmacy and
Biomedical Sciences, Pharmacy , Glasgow , UK.
(4)d Division of Clinical Pharmacology, Karolinska Institutet , Karolinska
University Hospital Huddinge , Stockholm , Sweden.
DOI: 10.1080/14787210.2016.1206468
PMID: 27351748 [Indexed for MEDLINE]
Yokoyama N(1), Sasaki H(1), Mori Y(1), Ono M(1), Tsurumi K(1), Kawada R(1),
Matsumoto Y(1), Yoshihara Y(1), Sugihara G(1), Miyata J(1), Murai T(1), Takahashi
H(1).
Author information:
(1)Department of Psychiatry, Graduate School of Medicine, Kyoto University,
Kyoto, Japan.
DOI: 10.1093/schbul/sbx092
PMCID: PMC5890451
PMID: 29036371 [Indexed for MEDLINE]
Author information:
(1)Neurobehavioral Research, Inc., 77 Ho'okele Street, 3rd Floor, Kahului, HI
96732, USA; Department of Medicine and Psychology, University of Hawaii,
Honolulu, HI 96822, USA. Electronic address: george@nbresearch.com.
(2)Neurobehavioral Research, Inc., 77 Ho'okele Street, 3rd Floor, Kahului, HI
96732, USA.
DOI: 10.1016/j.alcohol.2017.03.004
PMCID: PMC5600327
PMID: 28847380 [Indexed for MEDLINE]
Patterns of NSAIDs Use and Their Association with Other Analgesic Use in CKD.
Zhan M(1), St Peter WL(1), Doerfler RM(1), Woods CM(1), Blumenthal JB(1),
Diamantidis CJ(1), Hsu CY(1), Lash JP(1), Lustigova E(1), Mahone EB(1), Ojo
AO(1), Slaven A(1), Strauss L(1), Taliercio JJ(1), Winkelmayer WC(1), Xie D(1),
Fink JC(2); Chronic Renal Insufficiency Cohort (CRIC) Study Investigators.
Author information:
(1)Due to the number of contributing authors, the affiliations are provided in
the Supplemental Material.
(2)Due to the number of contributing authors, the affiliations are provided in
the Supplemental Material. jfink@som.umaryland.edu.
DOI: 10.2215/CJN.12311216
PMCID: PMC5672983
PMID: 28811297 [Indexed for MEDLINE]
255. Subst Abuse Treat Prev Policy. 2017 May 30;12(1):29. doi:
10.1186/s13011-017-0112-7.
Physical pain is common and associated with nonmedical prescription opioid use
among people who inject drugs.
Dahlman D(1)(2), Kral AH(3), Wenger L(3), Hakansson A(4)(5), Novak SP(6).
Author information:
(1)Department of Clinical Sciences Lund, Division of Psychiatry, Lund University,
Lund, Sweden. disa.dahlman@med.lu.se.
(2)Malmo Addiction Centre, Clinical Research Unit, Sodra Forstadsg. 35, plan 4,
SE-205 02, Malmo, Sweden. disa.dahlman@med.lu.se.
(3)Behavioral and Urban Health Program, RTI International, San Francisco, USA.
(4)Department of Clinical Sciences Lund, Division of Psychiatry, Lund University,
Lund, Sweden.
(5)Malmo Addiction Centre, Clinical Research Unit, Sodra Forstadsg. 35, plan 4,
SE-205 02, Malmo, Sweden.
(6)Battelle Memorial Institute, Baltimore, MD, USA.
BACKGROUND: People who inject drugs (PWID) often have poor health and lack access
to health care. The aim of this study was to examine whether PWID engage in
self-treatment through nonmedical prescription opioid use (NMPOU). We describe
the prevalence and features of self-reported physical pain and its association
with NMPOU.
METHODS: PWID (N = 702) in San Francisco, California (age 18+) were recruited to
complete interviewer administered surveys between 2011 and 2013. Multivariate
logistic regression analysis was conducted to examine the associations among
self-reported pain dimensions (past 24-h average pain, pain interference with
functional domains) and NMPOU, controlling for age, sex, psychiatric illness,
opioid substitution treatment, homelessness, street heroin use and unmet
healthcare needs.
RESULTS: Almost half of the sample reported pain, based on self-reported measures
in the 24 h before their interview. The most common pain locations were to their
back and lower extremities. Past 24-h NMPOU was common (14.7%) and associated
with past 24 h average pain intensity on a 10 point self-rating scale (adjusted
odds ratio [AOR] = 2.15, 95% confidence interval [CI] 1.21-3.80), and past 24 h
pain interference with general activity (AOR 1.82 [95% CI 1.04-3.21]), walking
ability (AOR 2.52 [95% CI 1.37-4.63]), physical ability (AOR 2.01 [95% CI
1.16-3.45]), sleep (AOR 1.98 [95% CI 1.13-3.48]) and enjoyment of life (AOR 1.79
[95% CI 1.02-3.15]).
CONCLUSION: Both pain and NMPOU are common among PWID, and highly correlated in
this study. These findings suggest that greater efforts are needed to direct
preventive health and services toward this population.
DOI: 10.1186/s13011-017-0112-7
PMCID: PMC5450090
PMID: 28558841 [Indexed for MEDLINE]
Vithalani ND(1), Heron C(2), Rao RE(2), Cardell AF(2), Stephens MB(2).
Author information:
(1)From the Penn State Health, State College, PA (NDV, CH, RER, MBS); Mount
Nittany Physician Group, State College (AFC). nvithalanimd@gmail.com.
(2)From the Penn State Health, State College, PA (NDV, CH, RER, MBS); Mount
Nittany Physician Group, State College (AFC).
Comment in
J Am Board Fam Med. 2018 May-Jun;31(3):488-489.
The antidiarrheal loperamide has had a recent, drastic increase in off-label use
as an alternative treatment for symptoms of opioid withdrawal. The concept of
this is easily discovered on the Internet and social media, where there are
multiple blogs and forums promoting loperamide use at doses of 70 to 200 mg per
day. Unfortunately, the serious side effects are not well recognized. Multiple
cases of cardiac dysrhythmias contributing to death have been highlighted in
recent literature. In November 2016, the US Food & Drug Administration released a
statement highlighting the potential heart effects and risk of death with high
doses of loperamide.1 This case regards a 22-year-old who took 200 mg of
loperamide per day for 2 years as an alternative to methadone in her attempts to
wean off heroin. Her subsequent spontaneous collapse, dysrhythmias, and acute
hospital treatment are reviewed in detail as they were contradictory to standard
therapy and required a multidisciplinary approach. Her outpatient management
addressed the complex biological, psychological, and social aspects of her
addiction.
DOI: 10.3122/jabfm.2017.06.170066
PMID: 29180560 [Indexed for MEDLINE]
Author information:
(1)Ministry of Health and Social Welfare, Republic of Srpska, Bosnia and
Herzegovina.
(2)Department of Social Pharmacy, University of Banja Luka, Republic of Srpska,
Bosnia and Herzegovina.
(3)Health Insurance Fund of Republika Srpska, Republic of Srpska, Bosnia and
Herzegovina.
(4)Medicine Usage in South Africa (MUSA), North-West University, Potchefstroom,
South Africa.
(5)Public Health Institute, Republic of Srpska, Bosnia and Herzegovina.
(6)Department of Pharmacoepidemiology, Strathclyde Institute of Pharmacy and
Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
(7)Division of Clinical Pharmacology, Karolinska Institute, Karolinska University
Hospital Huddinge, Stockholm, Sweden.
DOI: 10.4103/jrpp.JRPP_17_12
PMCID: PMC5463547
PMID: 28616436
Author information:
(1)Department of Biology, Wesleyan University, Middletown, CT 06105, USA.
(2)Department of Biology, Wesleyan University, Middletown, CT 06105, USA
msinger@wesleyan.edu.
DOI: 10.1242/jeb.143800
PMID: 28814608 [Indexed for MEDLINE]
259. BMC Health Serv Res. 2017 Feb 13;17(1):136. doi: 10.1186/s12913-017-2072-z.
Author information:
(1)Rajshahi Medical College, University of Rajshahi, 6002, Rajshahi, Bangladesh.
shuvormc53@gmail.com.
(2)Rajshahi Medical College Hospital, Rajshahi, Bangladesh.
Stingl JC(1), Welker S(2), Hartmann G(3), Damann V(4), Gerzer R(5).
Author information:
(1)Research Division, Federal Institute for Drugs and Medical Devices, Bonn,
Germany; Centre for Translational Medicine, University Bonn Medical Faculty,
Bonn, Germany.
(2)Research Division, Federal Institute for Drugs and Medical Devices, Bonn,
Germany.
(3)Institute for clinical chemistry and clinical pharmacology, University of
Bonn, Bonn, Germany.
(4)Space Medicine Office, European Space Agency, Cologne, Germany.
(5)Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany.
Drug safety and efficacy are highly variable among patients. Most patients will
experience the desired drug effect, but some may suffer from adverse drug
reactions or gain no benefit. Pharmacogenetic testing serves as a pre-treatment
diagnostic option in situations where failure or adverse events should be avoided
at all costs. One such situation is human space flight. On the international
space station (ISS), a list of drugs is available to cover typical emergency
settings, as well as the long-term treatment of common conditions for the use in
self-medicating common ailments developing over a definite period. Here, we
scrutinized the list of the 78 drugs permanently available at the ISS (year 2014)
to determine the extent to which their metabolism may be affected by genetic
polymorphisms, potentially requiring genotype-specific dosing or choice of an
alternative drug. The purpose of this analysis was to estimate the potential
benefit of pharmacogenetic diagnostics in astronauts to prevent therapy failure
or side effects.
DOI: 10.1371/journal.pone.0140764
PMCID: PMC4619198
PMID: 26489089 [Indexed for MEDLINE]
Author information:
(1)Department of Optometry, Faculty of Life Sciences, University of Benin,
Nigeria. Electronic address: jennifer.ebeigbe@uniben.edu.
(2)Department of Optometry, Faculty of Life Sciences, University of Benin,
Nigeria.
DOI: 10.1016/j.optom.2016.06.001
PMCID: PMC5383457
PMID: 27423689 [Indexed for MEDLINE]
262. Int J Pharm Pract. 2018 Aug;26(4):310-317. doi: 10.1111/ijpp.12405. Epub 2017
Sep
19.
Langer B(1), Bull E(1), Burgsthaler T(1), Glawe J(1), Schwobeda M(1), Simon K(1).
Author information:
(1)Faculty of Health, Nursing, Administration, University of Applied Sciences
Neubrandenburg, Neubrandenburg, Germany.
OBJECTIVES: The aim of this study was to assess the quality of counselling
provided for acute diarrhoea and to evaluate the role of the patient's approach
and different user groups in determining the outcome of counselling.
METHODS: The simulated patient methodology was used in all 21 community
pharmacies in a north-eastern German city. Four different scenarios related to
self-medication of acute diarrhoea were developed and used in all the pharmacies
(a total of 84 visits). The assessment form, completed immediately postvisit by
the simulated patient, included 9 objective items scored using dichotomous scales
to produce a scale from 0 to 9. After evaluating the data, every pharmacy
received individual performance feedback to encourage behavioural changes and
improve the quality of the counselling provided.
KEY FINDINGS: Overall, the quality of counselling was poor (mean score of 3.3/9
(37%)). The most common information provided was about dosage (87% of
interactions), while the least common information given was about side effects
(4% of interactions). The main effect was seen when comparing the product and
symptom requests (F(1,60) = 24.748, P < 0.001, ωp2 = 0.277). There was no effect
resulting from different user groups (F(1,28) = 0.237, P = 0.630, ωp2 = -0.026)
and no interaction between the type of request and different user groups (F(1,28)
= 3.395, P = 0.076, ωp2 = 0.073).
CONCLUSIONS: This study highlighted the current deficits in appropriate
counselling provided by community pharmacies in Germany.
DOI: 10.1111/ijpp.12405
PMCID: PMC6055702
PMID: 28925071 [Indexed for MEDLINE]
Author information:
(1)Non-Public Health Care Center Heart-to-Heart Mogilany, Rynek 4, Mogilany,
Poland. putamen@interia.pl.
Author information:
(1)Nuffield Department of Primary Care Health Sciences, University of Oxford,
Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, United Kingdom.
niklas.bobrovitz@phc.ox.ac.uk.
(2)Centre for Evidence-Based Medicine, University of Oxford, Oxford, United
Kingdom. niklas.bobrovitz@phc.ox.ac.uk.
(3)Nuffield Department of Primary Care Health Sciences, University of Oxford,
Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, United Kingdom.
(4)Centre for Evidence-Based Medicine, University of Oxford, Oxford, United
Kingdom.
(5)Faculty of Medicine, University of British Columbia, Vancouver, Canada.
(6)Faculty of Public Health and Policy, London School of Hygiene and Tropical
Medicine, London, United Kingdom.
(7)The Health Foundation, London, United Kingdom.
(8)Department of Critical Care Medicine, University of Calgary, Calgary, Canada.
(9)Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Canada.
(10)Bodelian Libraries, University of Oxford, Oxford, UK.
Comment in
BMC Med. 2018 Oct 5;16(1):169.
DOI: 10.1186/s12916-018-1104-9
PMCID: PMC6060538
PMID: 30045724 [Indexed for MEDLINE]
265. Int J Environ Res Public Health. 2018 Jun 4;15(6). pii: E1165. doi:
10.3390/ijerph15061165.
Knowledge, Attitude, and Practice with Respect to Antibiotic Use among Chinese
Medical Students: A Multicentre Cross-Sectional Study.
Hu Y(1), Wang X(2), Tucker JD(3), Little P(4), Moore M(5), Fukuda K(6), Zhou
X(7).
Author information:
(1)School of Public Health, The University of Hong Kong, Hong Kong, China.
huhubest@gmail.com.
(2)School of Public Health, Zhejiang University, Hangzhou 310058, China.
xiaominzjuhvd@gmail.com.
(3)UNC-China Project, University of North Carolina at Chapel Hill, Chapel Hill,
NC 27599, USA. jdtucker@med.unc.edu.
(4)Primary Care and Population Science, University of Southampton, Southampton
SO16 5ST, UK. p.little@soton.ac.uk.
(5)Primary Care and Population Science, University of Southampton, Southampton
SO16 5ST, UK. mvm198@soton.ac.uk.
(6)School of Public Health, The University of Hong Kong, Hong Kong, China.
kfukuda@hku.hk.
(7)School of Public Health, Zhejiang University, Hangzhou 310058, China.
zhouxudong@zju.edu.cn.
DOI: 10.3390/ijerph15061165
PMCID: PMC6025109
PMID: 29867005 [Indexed for MEDLINE]
Author information:
(1)a Center for Community and Health Disparities Research , National Development
and Research Institutes, Inc. , New York , NY , USA.
(2)b Center for Drug Use and HIV/HCV Research , New York University , New York ,
NY , USA.
(3)c Institute for Infectious Disease Research , National Development and
Research Institutes, Inc. , New York , NY , USA.
DOI: 10.1080/10826084.2017.1306563
PMCID: PMC5628147
PMID: 28622067 [Indexed for MEDLINE]
Author information:
(1)BPharm. Pharmacist and Assistant Scientist at Johnson & Johnson Brasil, São
José dos Campos (SP), Brazil.
(2)MSc, PhD. Pharmacist and Professor, School of Medicine, Universidade Federal
do Amazonas (UFAM), Manaus (AM), Brazil, and Postgraduate Program on
Pharmaceutical Sciences, Universidade de Sorocaba (UNISO), Sorocaba (SP), Brazil.
(3)MSc, PhD. Pharmacist and Professor, School of Pharmaceutical Sciences,
Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil.
DOI: 10.1590/1516-3180.2018.0168060818
PMID: 30570092 [Indexed for MEDLINE]
Author information:
(1)King Fahd Medical City, Emergency Department, 395529 Riyadh 11375, Saudi
Arabia. Electronic address: dr.sharafaldeen@yahoo.com.
(2)King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia.
Electronic address: S.nafesa@hotmail.com.
(3)King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia.
Electronic address: Aliyah80@live.com.
(4)King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia.
Electronic address: Mazen.humaid@gmail.com.
(5)King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia.
Electronic address: Haitham.almuhaidib@gmail.com.
(6)King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia.
Electronic address: Faleidan@gmail.com.
Copyright © 2017 King Saud Bin Abdulaziz University for Health Sciences.
Published by Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.jiph.2016.09.016
PMID: 28162966 [Indexed for MEDLINE]
269. Brain Sci. 2018 May 14;8(5). pii: E88. doi: 10.3390/brainsci8050088.
Author information:
(1)Camden and Islington NHS Foundation Trust, London NW1 0PE, UK.
antonio.metastasio@candi.nhs.uk.
(2)Centre for Clinical & Health Research Services, School of Life and Medical
Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.
antonio.metastasio@candi.nhs.uk.
(3)Centre for Clinical & Health Research Services, School of Life and Medical
Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK. ngrttl@gmail.com.
(4)Centre for Clinical & Health Research Services, School of Life and Medical
Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.
giovanni.martinotti@gmail.com.
(5)Department of Neuroscience, Imaging, and Clinical Science, "G. d'Annunzio"
University of Chieti-Pescara, 66100 Chieti, Italy. giovanni.martinotti@gmail.com.
(6)Centre for Clinical & Health Research Services, School of Life and Medical
Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.
o.corazza@herts.ac.uk.
DOI: 10.3390/brainsci8050088
PMCID: PMC5977079
PMID: 29757929
Use of medicines by patients of the primary health care of the Brazilian Unified
Health System.
Costa CMFN(1), Silveira MR(2), Acurcio FA(2), Guerra AA Junior(2), Guibu IA(3),
Costa KS(4)(5)(6), Karnikowski MGO(7), Soeiro OM(8), Leite SN(9), Costa EA(10),
Nascimento RCRMD(1), Araújo VE(11), Álvares J(2).
Author information:
(1)Programa de Pós-Graduação em Medicamentos e Assistência Farmacêutica.
Faculdade de Farmácia. Universidade Federal de Minas Gerais. Belo Horizonte, MG,
Brasil.
(2)Departamento de Farmácia Social. Faculdade de Farmácia. Universidade Federal
de Minas Gerais. Belo Horizonte, MG, Brasil.
(3)Faculdade de Ciências Médicas. Santa Casa de São Paulo. São Paulo, SP, Brasil.
(4)Núcleo de Estudos de Políticas Públicas. Universidade Estadual de Campinas.
Campinas, SP, Brasil.
(5)Programa de Pós-Graduação em Saúde Coletiva. Departamento de Saúde Coletiva.
Faculdade de Ciências Médicas. Universidade Estadual de Campinas. Campinas, SP,
Brasil.
(6)Programa de Pós-Graduação em Epidemiologia. Faculdade de Medicina.
Universidade Federal do Rio Grande do Sul. Porto Alegre, RS, Brasil.
(7)Faculdade de Ceilândia. Universidade de Brasília. Brasília, DF, Brasil.
(8)Faculdade de Ciências Farmacêuticas. Pontifícia Universidade Católica de
Campinas. Campinas, SP, Brasil.
(9)Departamento de Ciências Farmacêuticas. Universidade Federal de Santa
Catarina, Florianópolis, SC, Brasil.
(10)Instituto de Saúde Coletiva. Universidade Federal da Bahia. Salvador, BA,
Brasil.
(11)Instituto de Ciências Biológicas da Saúde. Pontifícia Universidade Católica
de Minas Gerais. Belo Horizonte, MG, Brasil.
DOI: 10.11606/S1518-8787.2017051007144
PMCID: PMC5676385
PMID: 29160464 [Indexed for MEDLINE]
Prospective daily diary study reporting of any and all symptoms in healthy adults
in Pakistan: prevalence and response.
Erratum in
BMJ Open. 2018 Jun 30;8(6):.
© Article author(s) (or their employer(s) unless otherwise stated in the text of
the article) 2017. All rights reserved. No commercial use is permitted unless
otherwise expressly granted.
DOI: 10.1136/bmjopen-2016-014998
PMCID: PMC5695404
PMID: 29138192 [Indexed for MEDLINE]
272. Int J Pharm Pract. 2017 Dec;25(6):438-446. doi: 10.1111/ijpp.12334. Epub 2017
Mar
6.
Author information:
(1)Department of Pharmacy and Therapeutics, School of Pharmacy, University of
Pittsburgh, Pittsburgh, PA, USA.
(2)Department of Behavioral and Community Health Sciences, Graduate School of
Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
DOI: 10.1111/ijpp.12334
PMCID: PMC5724494
PMID: 28261882 [Indexed for MEDLINE]
Primary Care Patients with Drug Use Report Chronic Pain and Self-Medicate with
Alcohol and Other Drugs.
Author information:
(1)Clinical Addiction Research and Education (CARE) Unit, Section of General
Internal Medicine, Department of Medicine, Boston Medical Center and Boston
University School of Medicine, 801 Massachusetts Avenue, 2nd floor, Boston, MA,
02118, USA. Dan.Alford@bmc.org.
(2)Clinical Addiction Research and Education (CARE) Unit, Section of General
Internal Medicine, Department of Medicine, Boston Medical Center and Boston
University School of Medicine, 801 Massachusetts Avenue, 2nd floor, Boston, MA,
02118, USA.
(3)Department of Community Health Sciences, Boston University School of Public
Health, Boston, MA, USA.
(4)Department of Biostatistics, Boston University School of Public Health,
Boston, MA, USA.
(5)Data Coordinating Center, Boston University School of Public Health, Boston,
MA, USA.
Comment in
J Gen Intern Med. 2016 May;31(5):451-2.
J Gen Intern Med. 2016 May;31(5):533.
BACKGROUND: Chronic pain is common among patients with drug use disorders. The
prevalence of chronic pain and its consequences in primary care patients who use
drugs is unknown.
OBJECTIVES: To examine: 1) the prevalence of chronic pain and pain-related
dysfunction among primary care patients who screen positive for drug use, and 2)
the prevalence of substance use to self-medicate chronic pain in this population.
DESIGN: This was a cross-sectional analysis.
PARTICIPANTS: This study included 589 adult patients who screened positive for
any illicit drug use or prescription drug misuse, recruited from an urban,
hospital-based primary care practice.
MAIN MEASURES: Both pain and pain-related dysfunction were assessed by numeric
rating scales, and grouped as: (0) none, (1-3) mild, (4-6) moderate, (7-10)
severe. Questions were asked about the use of substances to treat pain.
KEY RESULTS: Among 589 participants, chronic pain was reported by 87% (95% CI:
84-90%), with 13% mild, 24% moderate and 50% severe. Pain-related dysfunction was
reported by 74% (95% CI: 70-78%), with 15% mild, 23% moderate, and 36% severe. Of
the 576 that used illicit drugs (i.e., marijuana, cocaine, and/or heroin), 51%
reported using to treat pain (95% CI: 47-55% ). Of the 121 with prescription drug
misuse, 81% (95% CI: 74-88%) used to treat pain. Of the 265 participants who
reported any heavy drinking in the past 3 months, 38% (95% CI: 32-44%) did so to
treat pain compared to 79% (95% CI: 68-90%) of the 57 high-risk alcohol users.
CONCLUSIONS: Chronic pain and pain-related dysfunction were the norm for primary
care patients who screened positive for drug use, with nearly one-third reporting
both severe pain and severe pain-related dysfunction. Many patients using illicit
drugs, misusing prescription drugs and using alcohol reported doing so in order
to self-medicate their pain. Pain needs to be addressed when patients are
counseled about their substance use.
DOI: 10.1007/s11606-016-3586-5
PMCID: PMC4835374
PMID: 26809204 [Indexed for MEDLINE]
Author information:
(1)Dipartimento di Salute Mentale e Dipendenze Patologiche, Modena, Italy.
(2)Dipartimento di Salute Mentale e Dipendenze Patologiche, Modena, Italy.
f.mungai@ausl.mo.it.
(3)Department of Mental Health & Drug Abuse, AUSL Modena, Viale Muratori 201,
41124, Modena, Italy. f.mungai@ausl.mo.it.
BACKGROUND: St John's wort (Hypericum perforatum) has been known for centuries
for its therapeutic properties and its efficacy as an antidepressant has been
confirmed by a growing body of evidence. During the last two decades it has also
come to prominence with a wider public, due to advertising efforts across Europe
and United States of America. However, its availability without prescription, as
an over-the-counter medication, raises some concern regarding its clinical
management and unsupervised administration to individuals with psychopathological
risks. To date, the evidence available regarding the administration of Hypericum
in people with severe mental health problems is still meager and refers mainly to
affective disorder spectrum or psychotic relapse in people with established
diagnoses. To the best of our knowledge, this is the first report regarding the
onset of psychotic features in a patient presenting with psychotic diathesis.
CASE PRESENTATION: The case discussed in this report is a 25-year-old white man,
not known to the psychiatric services, with a history of brief and self-remitting
drug-induced psychosis and a positive family history of psychotic depression. He
was admitted to hospital due to the onset of florid psychotic symptoms
concomitant with self-administration of Hypericum perforatum.
CONCLUSIONS: The aim of this report is to promote further systematic research,
draw the attention of clinicians to the potential risks of Hypericum
precipitating psychosis, and raise awareness among health professionals to
investigate and caution their patients on the haphazard use of phytotherapeutics
such as Hypericum.
DOI: 10.1186/s13256-017-1302-7
PMCID: PMC5430601
PMID: 28502251 [Indexed for MEDLINE]
Ashara KC(1), Paun JS(1), Soniwala MM(1), Chavda JR(1), Mendapara VP(2), Mori
NM(3).
Author information:
(1)Department of Pharmaceutics, B.K. Mody Govt. Pharmacy College, Rajkot 360003,
Gujarat, India.
(2)Department of Pharmaceutical Sciences, Saurashtra University, Rajkot-360005,
Gujarat, India.
(3)Department of Pharmaceutical Sciences, Saurashtra University, Rajkot-360005,
Gujarat, India; Torrel (Hospital Division) a Member of Torrent Group, Ahmedabad,
Gujarat, India.
As compared to gel and other topical preparations microemulgel has been prepared
by screening of oils, emulsifier, and co-emulsifier on bases of solubility of an
API in it. An API has high solubility and oil may also have more or less
pharmacological property, so it may assist the therapeutic action of API. Due to
presence of oil portion, it leads to more penetration of API in the skin. Oil
Micelle Size was less than 500 nm which provides more area for absorption of API
in the skin so more penetration and more effective than macro-emulsion.
Microemulgel has an advantage of emulgel that has dual benefits of micro-emulsion
and gel and several other desirable properties like good consistency,
thyrotrophic, greaseless, easily spreadable as well as removable, emollient,
non-staining, water soluble, longer shelf-life, bio-friendly, transparent,
pleasant appearance, ability of patients for self-medication, termination of
medications will be easy, etc.
DOI: 10.1016/j.jsps.2014.08.002
PMCID: PMC4908067
PMID: 27330376
276. BMJ Health Care Inform. 2019 Aug;26(1). pii: e100050. doi:
10.1136/bmjhci-2019-100050.
Author information:
(1)University of Gondar, College of Medicine and Health Sciences, Institute of
Public Health, Gondar, Ethiopia kassahundessie@gmail.com.
(2)University of Gondar, College of Medicine and Health Sciences, Institute of
Public Health, Gondar, Ethiopia.
(3)University of British Columbia, Research Pavilion, Rm 566, 828 W 10th,
Vancouver, BC, V5Z 1 M9, Canada.
DOI: 10.1136/bmjhci-2019-100050
PMID: 31484661
277. Psychiatr Pol. 2018 Apr 30;52(2):261-273. doi: 10.12740/PP/68472. Epub 2018
Apr
30.
Author information:
(1)Klinika Psychiatrii Uniwersytetu Medycznego w Białymstoku.
(2)Zakład Statystyki i Informatyki Medycznej Uniwersytetu Medycznego w
Białymstoku.
(3)Klinika Psychiatryczna, Wydział Nauki o Zdrowiu, Warszawski Uniwersytet
Medyczny.
DOI: 10.12740/PP/68472
PMID: 29975366 [Indexed for MEDLINE]
Author information:
(1)Pietro Vassallo, Department of Surgery, Royal United Hospitals Bath NHS
Foundation Trust, Combe Park, Bath, BA1 3NG, United Kingdom, p.vassallo@nhs.net.
PMCID: PMC6406064
PMID: 30825277 [Indexed for MEDLINE]
Author information:
(1)Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA,
30322, USA.
(2)Department of Ecology and Evolutionary Biology, University of Michigan, 830 N
University Avenue, Ann Arbor, MI, 48109, USA.
© 2016 The Authors. Journal of Animal Ecology © 2016 British Ecological Society.
DOI: 10.1111/1365-2656.12558
PMID: 27286503 [Indexed for MEDLINE]
280. Subst Abuse Treat Prev Policy. 2015 Mar 15;10:12. doi: 10.1186/s13011-015-
0006-5.
Sagoe D(1), McVeigh J(2), Bjørnebekk A(3), Essilfie MS(4), Andreassen CS(5)(6),
Pallesen S(7).
Author information:
(1)Department of Psychosocial Science, University of Bergen, Christiesgate 12,
5015, Bergen, Norway. dominic.sagoe@psysp.uib.no.
(2)Centre for Public Health, Liverpool John Moores University, 15-21 Webster
Street, Liverpool, L3 2ET, UK. j.mcveigh@ljmu.ac.uk.
(3)Department of Physical Medicine and Rehabilitation, Unit of Neuropsychology,
Oslo University Hospital, Kirkeveien 166, Ullevål, Norway.
astrid.bjornebekk@psykologi.uio.no.
(4)Departments of Surgery and Paediatrics, La General Hospital, PMB, Accra,
Ghana. Essilfie@gmail.com.
(5)Department of Psychosocial Science, University of Bergen, Christiesgate 12,
5015, Bergen, Norway. cecilie.andreassen@psych.uib.no.
(6)The Competence Centre, Bergen Clinics Foundation, Vestre Torggate 11, 5015,
Bergen, Norway. cecilie.andreassen@psych.uib.no.
(7)Department of Psychosocial Science, University of Bergen, Christiesgate 12,
5015, Bergen, Norway. staale.pallesen@psysp.uib.no.
DOI: 10.1186/s13011-015-0006-5
PMCID: PMC4377045
PMID: 25888931 [Indexed for MEDLINE]
281. Eye (Lond). 2016 Jan;30(1):64-7. doi: 10.1038/eye.2015.185. Epub 2015 Oct 2.
Author information:
(1)Retina and Vitreous Unit, Department of Ophthalmology, University College
Hospital, Ibadan, Nigeria.
DOI: 10.1038/eye.2015.185
PMCID: PMC4709532
PMID: 26427986 [Indexed for MEDLINE]
282. Drug Alcohol Depend. 2017 Apr 1;173 Suppl 1:S4-S10. doi:
10.1016/j.drugalcdep.2016.03.014.
Understanding the demand side of the prescription opioid epidemic: Does the
initial source of opioids matter?
Author information:
(1)Washington University in St. Louis, Department of Psychiatry, Campus Box 8134,
660 S. Euclid Avenue, St. Louis, MO 63110, USA. Electronic address:
Cicerot@wustl.edu.
(2)Washington University in St. Louis, Department of Psychiatry, Campus Box 8134,
660 S. Euclid Avenue, St. Louis, MO 63110, USA.
BACKGROUND: These studies were carried out to examine whether the onset and
progression of an opioid substance use disorder (SUD) differed in those who first
used opioids to get "high" compared to those who received a prescription from a
doctor to relieve pain (Non-Rx vs. Rx groups, respectively).
METHODS: A subset of patients (N=214) from an ongoing larger study of patients
entering one of 125 drug treatment programs for opioid use disorder across the
country agreed to give up their anonymity and participate in structured and
open-ended online interviews examining drug abuse patterns.
RESULTS: With the exception that the Non-Rx group began their opioid abuse at a
younger age than the Rx group and more quickly evolved from initial exposure to
regular opioid abuse, there were relatively few differences in the
characteristics, patterns and trajectories of opioid abuse. The vast majority of
patients in both groups, most of whom had serious, antecedent psychiatric
disorders, indicated that they used opioids to self-medicate psychological
problems (67-73%) and/or stated that opioids provided a means to "escape" from
the stresses of everyday life (79-85%). As the SUD progressed, for many
individuals any "positive" attributes of opioids waned and avoidance of
withdrawal became the overriding concern, often serving as the impetus for
treatment.
CONCLUSIONS: Our results suggest that self-treatment of co-morbid psychiatric
disturbances is a powerful motivating force to initiate and sustain abuse of
opioids and that the initial source of drugs-a prescription or experimentation-is
largely irrelevant in the progression to a SUD.
Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.
DOI: 10.1016/j.drugalcdep.2016.03.014
PMID: 28363319 [Indexed for MEDLINE]
Cannabis use and anxiety: is stress the missing piece of the puzzle?
Author information:
(1)Federation University Australia , Ballarat, VIC , Australia.
(2)University of New England , Armidale, NSW , Australia.
(3)The Australian National University , Canberra, ACT , Australia.
OBJECTIVE: Comorbidity between anxiety and cannabis use is common yet the nature
of the association between these conditions is not clear. Four theories were
assessed, and a fifth hypothesis tested to determine if the misattribution of
stress symptomology plays a role in the association between state-anxiety and
cannabis.
METHODS: Three-hundred-sixteen participants ranging in age from 18 to 71 years
completed a short online questionnaire asking about their history of cannabis use
and symptoms of stress and anxiety.
RESULTS: Past and current cannabis users reported higher incidence of lifetime
anxiety than participants who had never used cannabis; however, these groups did
not differ in state-anxiety, stress, or age of onset of anxiety. State-anxiety
and stress were not associated with frequency of cannabis use, but reported use
to self-medicate for anxiety was positively associated with all three. Path
analyses indicated two different associations between anxiety and cannabis use,
pre-existing and high state-anxiety was associated with (i) higher average levels
of intoxication and, in turn, acute anxiety responses to cannabis use; (ii)
frequency of cannabis use via the mediating effects of stress and
self-medication.
CONCLUSION: None of the theories was fully supported by the findings. However, as
cannabis users reporting self-medication for anxiety were found to be
self-medicating stress symptomology, there was some support for the
stress-misattribution hypothesis. With reported self-medication for anxiety being
the strongest predictor of frequency of use, it is suggested that researchers,
clinicians, and cannabis users pay greater attention to the overlap between
stress and anxiety symptomology and the possible misinterpretation of these
related but distinct conditions.
DOI: 10.3389/fpsyt.2014.00168
PMCID: PMC4241884
PMID: 25505428
Author information:
(1)Department of Community Oral Health and Clinical Prevention, Faculty of
Dentistry, University of Malaya, Kuala Lumpur, Malaysia. Email: jendoss@um.edu.my
Background: The aim of this study was to explore reasons for delayed
health-seeking for late stage oral cancer patients. Methods: Semi-structured
in-depth interviews were conducted with 35 oral cancer patients with TNM stage
III to IV disease, who were treated at six tertiary regional centres managing
oral cancer throughout Malaysia. Interviews were audio-recorded, transcribed
verbatim, coded using NVivo (version 10.0) qualitative software and analysed
using framework analysis. Results: Participants interpreted their early symptoms
as a minor condition and did not consider it as requiring immediate attention.
Four types of coping strategies causing delayed help-seeking emerged: 1)
self-remedy 2) self-medication 3) seeking traditional healers and 4) consulting
general medical practitioners (GPs) instead of dentists. Socio-economic factors,
cultural beliefs and religious practices have some influence on diagnostic delay.
Conclusion: Low levels of public knowledge and awareness regarding early signs
and symptoms of oral cancer as well as GPs’ misdiagnosis of early lesions results
in delayed diagnosis.
DOI: 10.22034/APJCP.2018.19.10.2935
PMCID: PMC6291039
PMID: 30362327 [Indexed for MEDLINE]
285. Nat Sci Sleep. 2017 Mar 17;9:97-108. doi: 10.2147/NSS.S128095. eCollection
2017.
Romero K(1), Goparaju B(1), Russo K(1), Westover MB(2), Bianchi MT(1).
Author information:
(1)Neurology Department, Massachusetts General Hospital; Division of Sleep
Medicine, Harvard Medical School, Boston, MA, USA.
(2)Neurology Department, Massachusetts General Hospital.
DOI: 10.2147/NSS.S128095
PMCID: PMC5364017
PMID: 28360539
286. J Pain Res. 2015 Apr 23;8:175-87. doi: 10.2147/JPR.S79618. eCollection 2015.
Author information:
(1)Pathopsychology, University of Bamberg, Bamberg, Germany ; Physiological
Psychology, University of Bamberg, Bamberg, Germany.
(2)Pathopsychology, University of Bamberg, Bamberg, Germany.
(3)Physiological Psychology, University of Bamberg, Bamberg, Germany.
DOI: 10.2147/JPR.S79618
PMCID: PMC4412487
PMID: 25960674
The aim of the study was to examine the prevalence and type of medicines used by
high school students in the Czech Republic and to analyze association between use
of medicines during last 6 months and self medication with different
socio-demographic and lifestyle aspects. A cross-sectional study was conducted in
high schools from two regions and three towns in the Czech Republic. The study
sample was a student population of nine selected high schools. The study was
approved by the local Ethics Committees and school board and was conducted in
compliance with the ethical principles of the Declaration of Helsinki.
Questionnaires respecting anonymity were distributed to the students during the
regular class period. Students answered closed and open questions divided into
six sections focussing on their experience with chronic and irregular use of
medicines, medicines use during last six months, conditions treated, type and
source of used medicines. A modified log-linear Poisson regression model with a
robust variance estimator (sandwich) was used for statistical analysis. In total,
979 students, aged 14-21 years (mean age 17 years) participated in the study: 32%
were male and 68% female; 19% of students reported regular use of medicines for
chronic disease. The use of medicines during the last 6 months was reported by
83% of students; 42% of them reported the use of both prescription and over the
counter (OTC) medicines; 22% the use only of OTC, and 31% only prescription
medicines. Allergy, asthma, disorders of the thyroid gland, atopic dermatitis,
and hypertensive diseases were among the most frequent long-term diseases. The
most frequent groups of medicines used for the treatment of long-term diseases
were systemic antihistamines, thyroid preparations, and respiratory drugs.
Nonsteroidal anti-inflammatory medicines, ibuprofen and paracetamol were the most
frequently used medicines during last six months. The study results showed quite
extensive use of both prescription and OTC medicines in students of high schools
between 14-21 years of age in the Czech Republic. Statistically significant
associations were found between use of medicines during last 6 months and type of
school, sex and chronic diseases, and between self-medication and sex.
PMID: 26642691 [Indexed for MEDLINE]
Antibiotics are drugs often used. This drugs used without legitimate indications
or incorrectly may cause not satisfactory clinical results. It is therefore
important for the society members to be aware of what is an antibiotic and which
benefits and risks its use may bring. The survey was conducted in 2010. Objective
of the study was to obtain information on the current knowledge and beliefs about
antibiotic therapy of Poles. The research material consisted of 609
questionnaires and interviews, conducted among the adult population residing in
the Lublin voivodeship. The study shows that rural inhabitants don't know the
term herbal medicine or antibiotic more often than inhabitants in the city.
Similarly, they more often don't know the action of antibiotics as well as use
them less frequently. Poles treat them as an emergency exit if they are not
helped by home treatments. There was a problem of overuse of antibiotics, related
to young people, which were busy and have no time for illness. Self-medication in
the antibiotic therapy also occurs and is caused, among others, by undisciplined
patients. The respondents admited that they have antibiotics from the previous
treatment, from pharmacy, or from family or friends. However, residents of rural
areas using an antibiotic most frequently, cited a pharmacy as the source of this
drug. Other issues dealt within this study generally doesn't differ for rural
inhabitants from the data obtained among the urban population.
Author information:
(1)Universidade de Sorocaba, Post-Graduate Program in Pharmaceutical Sciences,
Sorocaba, São Paulo, Brazil.
(2)Faculty of Medicine, Federal University of Amazonas, Manaus, Brazil.
(3)Post-Graduate Program in Pharmaceutical Sciences, Universidade de Sorocaba,
Sorocaba, Brazil.
OBJECTIVES: This study aimed to assess the prevalence of sleeping pill use in
Brazil.
DESIGN: A population-based cross-sectional study with a three-stage cluster
sampling design (census tracts, households and adult residents) was used.
SETTING: The Brazilian 2013 National Health Survey was used.
PARTICIPANTS: The study population consisted of household residents aged ≥18
years. A total of 60 202 individuals were interviewed, including 52.9% women, and
21% reported depressive symptoms.
OUTCOMES: The primary outcome was sleeping pill use, which was self-reported with
the question, 'Over the past two weeks, have you used any sleeping pills?' The
prevalence was calculated and stratified according to sociodemographic
characteristics. The associated factors were identified from prevalence ratios
(PRs) obtained through a Poisson regression with robust variance and adjusted for
sex and age.
RESULTS: The prevalence of sleeping pill use was 7.6% (95% CI 7.3% to 8.0%), and
the average treatment duration was 9.75 (95% CI 9.49 to 10.00) days.
Self-medication was found in 11.2% (95% CI 9.6% to 12.9%) of users. The following
factors were associated with sleeping pill use: female sex (PR=2.21; 95% CI 1.97
to 2.47), an age of ≥60 years (PR=5.43; 95% CI 4.14 to 7.11) and smoking
(PR=1.47; 95% CI 1.28 to 1.68). Sleeping pill use was also positively associated
with the severity of depressive symptoms (p<0.001), whereas alcohol intake was
inversely associated (PR=0.66; 95% CI 0.56 to 0.77).
CONCLUSIONS: One in every 13 Brazilians adults uses sleeping pills. There is a
lack of information about the reasons for this use. Actions are required to raise
awareness about the risks. The results could assist programmes in targeting
rational sleeping pill use and the identification of factors demanding
intervention.
© Article author(s) (or their employer(s) unless otherwise stated in the text of
the article) 2017. All rights reserved. No commercial use is permitted unless
otherwise expressly granted.
DOI: 10.1136/bmjopen-2017-016233
PMCID: PMC5541607
PMID: 28698341 [Indexed for MEDLINE]
Author information:
(1)Unité de Neurobiologie Intégrative des Systèmes Cholinergiques, Department of
Neuroscience, CNRS UMR 3571, Institut Pasteur , Paris , France.
DOI: 10.3389/fpsyt.2016.00160
PMCID: PMC5030478
PMID: 27708591
291. BMC Neurol. 2017 Sep 4;17(1):171. doi: 10.1186/s12883-017-0952-9.
Author information:
(1)Multiple Sclerosis Center, Neurocenter of Southern Switzerland, Ospedale
Regionale di Lugano, Lugano, Switzerland.
(2)Merck (Schweiz) AG, Zug, Switzerland.
(3)Multiple Sclerosis Center, Neurocenter of Southern Switzerland, Ospedale
Regionale di Lugano, Lugano, Switzerland. Claudio.Gobbi@eoc.ch.
(4)Multiple Sclerosis Center, Neurocenter of Southern Switzerland, Ospedale
Regionale di Lugano, Via Tesserete 46, 6903, Lugano, Switzerland.
Claudio.Gobbi@eoc.ch.
DOI: 10.1186/s12883-017-0952-9
PMCID: PMC5584024
PMID: 28870152 [Indexed for MEDLINE]
Author information:
(1)Department of Public Health Sciences, Medical University of South Carolina,
Charleston, South Carolina. Electronic address: wiled@musc.edu.
(2)Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
(3)Department of Public Health Sciences, Medical University of South Carolina,
Charleston, South Carolina; Department of Medicine, Medical College of Wisconsin,
Milwaukee, Wisconsin.
DOI: 10.1016/j.amjms.2017.08.021
PMCID: PMC5896319
PMID: 29406037 [Indexed for MEDLINE]
Kawai Y(1), DeMonbrun AG(2), Chambers RS(2), Nolan DA(3), Dolcourt BA(4), Malas
NM(5)(6), Quasney MW(2).
Author information:
(1)Divisions of Pediatric Critical Care Medicine and kawai.yu@mayo.edu.
(2)Divisions of Pediatric Critical Care Medicine and.
(3)Pediatric Neurology, Department of Pediatrics and Communicable Diseases.
(4)Division of Toxicology, Department of Emergency Medicine, Wayne State
University School of Medicine, Detroit, Michigan.
(5)Division of Child and Adolescent Psychiatry, Department of Psychiatry, and.
(6)Department of Pediatrics and Communicable Diseases, C.S. Mott Children's
Hospital, University of Michigan, Ann Arbor, Michigan; and.
DOI: 10.1542/peds.2015-3779
PMID: 27940505 [Indexed for MEDLINE]
294. Am J Addict. 2015 Aug;24(5):403-9. doi: 10.1111/ajad.12213. Epub 2015 May 25.
Daniulaityte R(1), Carlson R(1), Brigham G(2), Cameron D(3), Sheth A(3).
Author information:
(1)Department of Community Health, Center for Interventions, Treatment, and
Addictions Research (CITAR), Boonshoft School of Medicine, Wright State
University, Dayton, Ohio.
(2)Department of Psychiatry, University of Cincinnati, ADAPT, Roseburg, Oregon.
(3)Ohio Center of Excellence in Knowledge-enabled Computing (Kno.e.sis), Wright
State University, Dayton, Ohio.
BACKGROUND: Illicit use of buprenorphine has increased in the U.S., but our
understanding of its use remains limited. This study aims to explore Web-forum
discussions about the use of buprenorphine to self-treat opioid withdrawal
symptoms.
METHODS: PREDOSE, a novel Semantic Web platform, was used to extract relevant
posts from a Web-forum that allows free discussions on illicit drugs. First, we
extract information about the total number of buprenorphine-related posts per
year between 2005 and 2013. Second, PREDOSE was used to identify all posts that
potentially contained discussions about buprenorphine and opioid withdrawal. A
total number of 1,217 posts that contained these terms were extracted and entered
into NVivo data base. A random sample of 404 (33%) posts was selected and content
analyzed.
RESULTS: Buprenorphine-related posts increased over time, peaking in 2011. The
posts were about equally divided between those that expressed positive and
negative views about the effectiveness of buprenorphine in relieving withdrawal
symptoms. Web-forum participants emphasized that buprenorphine's effectiveness
may become compromised because of the "size of a person habit," and/or when users
repeatedly switch back and forth between buprenorphine and other illicit opioids.
Most posts reported use of significantly lower amounts of buprenorphine (≤2 mg)
than doses used in standard treatment. Concomitant use of other psychoactive
substances was also commonly reported, which may present significant health
risks.
CONCLUSIONS: Our findings highlight the usefulness of Web-based data in drug
abuse research and add new information about lay beliefs about buprenorphine that
may help inform prevention and policy measures.
DOI: 10.1111/ajad.12213
PMCID: PMC4527156
PMID: 26009867 [Indexed for MEDLINE]
Suswardany DL(1)(2), Sibbritt DW(1), Supardi S(3), Pardosi JF(3)(4), Chang S(1),
Adams J(1).
Author information:
(1)Australian Research Centre in Complementary and Integrative Medicine (ARCCIM),
Faculty of Health, University of Technology Sydney, Sydney, New South Wales,
Australia.
(2)Universitas Muhammadiyah Surakarta, Central Java, Indonesia.
(3)National Institute of Health Research and Development, Ministry of Health,
Indonesia.
(4)School of Public Health and Community Medicine, University of New South Wales,
Australia.
DOI: 10.1371/journal.pone.0173522
PMCID: PMC5362041
PMID: 28329019 [Indexed for MEDLINE]
Author information:
(1)Department of Psychology, University at Buffalo, State University of New York.
DOI: 10.1037/adb0000285
PMCID: PMC5605813
PMID: 28703614 [Indexed for MEDLINE]
297. J Headache Pain. 2016;17:33. doi: 10.1186/s10194-016-0628-7. Epub 2016 Apr 14.
Author information:
(1)SMI®, Department of Health science and Technology, Faculty of Medicine,
Aalborg University, Aalborg, Denmark.
(2)SMI®, Department of Health science and Technology, Faculty of Medicine,
Aalborg University, Aalborg, Denmark. gazerani@hst.aau.dk.
Erratum in
J Headache Pain. 2016;17:50.
BACKGROUND: Airplane headache (AH) is a headache that occurs during take-off and
landing. The pain is described as severe, unilateral, and located in the
fronto-orbital region. This study aimed at investigating the incidence of AH
among Scandinavian air-travelers, and to elucidating potential risk factors.
METHODS: An online, Danish-survey was developed. The questionnaire consisted of
14 questions and was distributed through the Facebook-pages of
Scandinavian-airlines and interest organizations. Participants reached the
questionnaire through a web-link.
RESULTS: Out of 254 responses, 89 noted that they suffered from headaches
associated to airplane travel. Of the 89, 21 cases the headache was severe and
limited to 30 min duration, as described in the ICH's criteria of AH. The
remaining 68 cases indicated that the headache lasted longer than 30 min. Our
data demonstrated that High-Altitude Headache (HAH) is a risk factor for
developing AH (p < 0.05). Triptans (19 %) and paracetamol (5 %) were reported
effective to relieve AH.
CONCLUSION: This study indicates that up to 8.3 % of the studied population
suffered from AH, with a higher incidence in those with a history of HAH.
Self-medication by triptans and paracetamol were reported effective for relieving
AH.
DOI: 10.1186/s10194-016-0628-7
PMCID: PMC4831956
PMID: 27080112 [Indexed for MEDLINE]
A Call to Action: The Active Role Psychiatrists and the DEA Must Take to Decrease
Harm from Psychotropic Drugs Acquired via the Internet.
Goldenberg M(1), Hassamal S(1), IsHak WW(2)(1), Haglund M(1), Miotto K(1),
Danovitch I(1).
Author information:
(1)Department of Psychiatry, Cedars Sinai Medical Center, Los Angeles,
California, USA.
(2)waguih.ishak@cshs.org.
DOI: 10.4088/JCP.15cr10606
PMID: 28076677 [Indexed for MEDLINE]
Okamoto I(1), Prieto J(1), Avery M(1), Moore K(2), Fader M(1), Sartain S(3),
Clancy B(3).
Author information:
(1)Faculty of Health Sciences, University of Southampton, University Road,
Southampton, SO17 1BJ, UK.
(2)Faculty of Nursing, University of Alberta, Edmonton, Canada.
(3)University of Southampton, University Road, Southampton SO17 1BJUK.
© Article author(s) (or their employer(s) unless otherwise stated in the text of
the article) 2017. All rights reserved. No commercial use is permitted unless
otherwise expressly granted.
DOI: 10.1136/bmjopen-2017-016453
PMCID: PMC5588948
PMID: 28871020 [Indexed for MEDLINE]
300. Risk Manag Healthc Policy. 2016 Jul 25;9:173-83. doi: 10.2147/RMHP.S98099.
eCollection 2016.
Author information:
(1)Division of Molecular Epidemiology, Jikei University School of Medicine.
(2)Faculty of Pharmacy, Musashino University, Shinmachi, Tokyo, Japan.
DOI: 10.2147/RMHP.S98099
PMCID: PMC4968996
PMID: 27555801
Author information:
(1)School of Public Health and Community Medicine, UNSW Medicine, UNSW, Level 3
Samuels Building, Sydney, 2052 NSW Australia.
(2)Diagnostic Microbiology Development Program, # 23 (First Floor), Street 310,
BKK 1, Khan Chamcar Morn, Phnom Penh, Cambodia.
(3)Department of Clinical Sciences, Institute of Tropical Medicine,
Nationalestraat 155, 2000 Antwerp, Belgium.
DOI: 10.1186/s13756-017-0187-y
PMCID: PMC5366159
PMID: 28352463
Author information:
(1)Department of Pharmacology and Pharmacognosy, University of Nairobi, Nairobi,
Kenya.
(2)Department of Pharmaceutics and Pharmacy Practice, University of Nairobi,
Nairobi, Kenya.
(3)Department of Pharmacoepidemiology, Strathclyde Institute of Pharmacy and
Biomedical Sciences, Strathclyde University, Glasgow, UK.
(4)Department of Laboratory Medicine, Division of Clinical Pharmacology,
Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm,
Sweden.
(5)Health Economics Centre, Liverpool University Management School, Liverpool
University, Liverpool, UK.
DOI: 10.4103/jrpp.JRPP_17_88
PMCID: PMC6036869
PMID: 30050960
Author information:
(1)Associate Professor, Department of Pharmacology, P.S. Medical College ,
Karamsad, Gujarat, India .
(2)Professor and Head, Department of Pharmacology, P.S. Medical College ,
Karamsad, Gujarat, India .
DOI: 10.7860/JCDR/2016/20600.8298
PMCID: PMC5028514
PMID: 27656460
304. Trop Med Int Health. 2017 May;22(5):567-575. doi: 10.1111/tmi.12854. Epub 2017
Mar 9.
Barber DA(1), Casquejo E(2), Ybañez PL(2), Pinote MT(2), Casquejo L(2), Pinote
LS(2), Estorgio M(2), Young AM(1).
Author information:
(1)Department of Epidemiology, University of Kentucky, Lexington, KY, USA.
(2)Island Ventures, Inc., Lapu-Lapu City, Cebu, Philippines.
DOI: 10.1111/tmi.12854
PMID: 28187247 [Indexed for MEDLINE]
305. Biol Pharm Bull. 2017 Oct 1;40(10):1730-1738. doi: 10.1248/bpb.b17-00340. Epub
2017 Aug 4.
Comparison of the Benefit Feeling Rate Based on the Sho of OTC Kakkonto, Cold
Remedy and Cold Remedy with Kakkonto Combination Product.
Okita M(1), Yayoshi Y(2), Ohara K(3), Negishi A(2), Akimoto H(2), Inoue N(1)(4),
Numajiri S(4), Ohshima S(1)(4), Honma S(5), Oshima S(2), Kobayashi D(1)(2).
Author information:
(1)Josai University Pharmacy.
(2)Department of Analytical Pharmaceutics and Informatics, Faculty of Pharmacy
and Pharmaceutical Sciences, Josai University.
(3)Laboratory of Drug Metabolism, Faculty of Pharmaceutical Sciences, Josai
International University.
(4)Laboratory of Pharmacy Management, Faculty of Pharmacy and Pharmaceutical
Sciences, Josai University.
(5)Onko-Do Kampo Akebono Yakkyoku Co., Ltd.
Kakkonto (KK), a traditional Japanese Kampo formulation for cold and flu, is
generally sold as an OTC pharmaceuticals used for self-medication. Kampo
formulations should be used according to the Sho-symptoms of Kampo medicine.
These symptoms refer to the subjective symptoms themselves. Although with OTC
pharmaceuticals, this is often not the case. We surveyed the relationship of
agreement of Sho with the benefit feeling rate (BFR) of patients who took KK
(n=555), cold remedies with KK (CK, n=315), and general cold remedies (GC, n=539)
using internet research. BFR of a faster recovery was greater in participants who
took the medication early and who had confidence in their physical strength in
all treatment groups. BFR was significantly higher in the GC group than in the KK
group for patients with headache, runny nose, blocked nose, sneezing, and cough.
BFR was also significantly higher in the GC group than in the CK group for
headache (males) and cough (females). BFR was the highest in the KK group for
stiff shoulders. All cold remedies were more effective when taken early, and the
larger the number of Sho that a patient had, the greater the BFR increased.
Therefore, a cold remedy is expected to be most effective when there are many
cold symptoms and when it is taken at an early stage of the common cold.
DOI: 10.1248/bpb.b17-00340
PMID: 28781292 [Indexed for MEDLINE]
Howes-Mischel R(1).
Author information:
(1)Department of Sociology and Anthropology, James Madison University,
Harrisonburg, VA, USA.
DOI: 10.3934/publichealth.2017.5.430
PMCID: PMC6111272
PMID: 30155497
Alshehri MD(1), Almutairi AT(1), Alomran AM(1), Alrashed BA(1), Kaliyadan F(1).
Author information:
(1)Department of Dermatology, College of Medicine, King Faisal University, Saudi
Arabia.
DOI: 10.4103/2229-5178.202273
PMCID: PMC5372432
PMID: 28405552
Untersmayr E(1).
Author information:
(1)Department of Pathophysiology and Allergy Research, Center of Pathophysiology,
Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
DOI: 10.1007/s40629-015-0085-x
PMCID: PMC5464390
PMID: 28603686
309. Pharmacy (Basel). 2018 Jun 7;6(2). pii: E52. doi: 10.3390/pharmacy6020052.
Author information:
(1)Department of Clinical Epidemiology, Leibniz Institute for Prevention Research
and Epidemiology-BIPS, Achterstraße 30, 28359 Bremen, Germany.
barrenberg@leibniz-bips.de.
(2)Department of Epidemiology and Health Monitoring, Robert Koch-Institute,
General-Pape-Straße 62-66, 12101 Berlin, Germany. knopfh@rki.de.
(3)Department of Clinical Epidemiology, Leibniz Institute for Prevention Research
and Epidemiology-BIPS, Achterstraße 30, 28359 Bremen, Germany.
garbe@leibniz-bips.de.
(4)Core Scientific Area 'Health Sciences' at the University of Bremen, Grazer
Str. 2, 28334 Bremen, Germany. garbe@leibniz-bips.de.
In order to assess the effects of prescription-only (Rx) to over-the-counter
(OTC) drug switches and related policies, it is imperative to distinguish
self-medication from OTC drug use. The objective of this study was to estimate
the OTC drug use in the adult population in Germany, to identify its predictors
and to highlight methodological differences when compared to the study of a
self-medication prevalence. Seven-day prevalence of OTC drug use was calculated
on the basis of information provided by 7091 participants of the German Health
Interview and Examination Survey for Adults (DEGS1) conducted between 2008 to
2011. Logistic regression analysis was used to identify predictors of OTC drug
use. Seven-day prevalence of OTC drug use was higher in women (47.16%) than in
men (33.17%). Female gender, an age of more than 60 years, reduced health status,
Rx drug use, and multi-morbidity were identified as predictors of OTC drug use.
The levels of OTC drug use were higher than the self-medication prevalence found
in the same data set probably because some OTC drugs are commonly prescribed by
physicians. Drug utilization studies should, therefore, make a methodological
distinction between self-medication and OTC drug use depending on whether the
focus is on drug safety or the impact of regulatory decisions on the trade
status.
DOI: 10.3390/pharmacy6020052
PMCID: PMC6024976
PMID: 29880765
Drinking to ease the burden: a cross-sectional study on trauma, alcohol abuse and
psychopathology in a post-conflict context.
Author information:
(1)Clinical Psychology and Psychotherapy, Department of Psychology, Bielefeld
University, Universitätsstraße 25, 33615, Bielefeld, Germany.
verena.ertl@uni-bielefeld.de.
(2)vivo international, Konstanz, Germany. verena.ertl@uni-bielefeld.de.
(3)Clinical Psychology and Psychotherapy, Department of Psychology, Bielefeld
University, P.O. Box 100131, 33501, Bielefeld, Germany.
verena.ertl@uni-bielefeld.de.
(4)Clinical Psychology and Psychotherapy, Department of Psychology, Bielefeld
University, Universitätsstraße 25, 33615, Bielefeld, Germany.
(5)vivo international, Konstanz, Germany.
BACKGROUND: It is likely that alcohol use and abuse increase during and after
violent conflicts. The most prominent explanation of this phenomenon has been
referred to as self-medication hypothesis. It predicts that psychotropic
substances are consumed to deal with conflict-related psychic strains and trauma.
In northern Uganda, a region that has been affected by a devastating civil war
and is characterized by high levels of alcohol abuse we examined the associations
between war-trauma, childhood maltreatment and problems related to alcohol use.
Deducing from the self-medication hypothesis we assumed alcohol consumption
moderates the relationship between trauma-exposure and psychopathology.
METHODS: A cross-sectional epidemiological survey targeting war-affected families
in post-conflict northern Uganda included data of male (n = 304) and female
(n = 365) guardians. We used standardized questionnaires in an interview format
to collect data on the guardians' socio-demography, trauma-exposure, alcohol
consumption and symptoms of alcohol abuse, PTSD and depression.
RESULTS: Symptoms of current alcohol use disorders were present in 46 % of the
male and 1 % of the female respondents. A multiple regression model revealed the
unique contributions of emotional abuse in the families of origin and trauma
experienced outside the family-context in the prediction of men's alcohol-related
symptoms. We found that alcohol consumption moderated the dose-effect
relationship between trauma-exposure and symptoms of depression and PTSD.
Significant interactions indicated that men who reported more alcohol-related
problems experienced less increase in symptoms of PTSD and depression with
increasing trauma-exposure.
CONCLUSIONS: The gradual attenuation of the dose-effect the more alcohol-related
problems were reported is consistent with the self-medication hypothesis. Hence,
the functionality of alcohol consumption has to be considered when designing and
implementing addiction treatment in post-conflict contexts.
DOI: 10.1186/s12888-016-0905-7
PMCID: PMC4921056
PMID: 27342048 [Indexed for MEDLINE]
Author information:
(1)Tan Tock Seng Hospital, Singapore.
(2)Research Division, Institute of Mental Health, Singapore.
(3)West Region, Institute of Mental Health, Singapore.
DOI: 10.5116/ijme.5d21.b621
PMID: 31381505
312. Front Psychiatry. 2019 May 15;10:274. doi: 10.3389/fpsyt.2019.00274.
eCollection
2019.
Hogarth L(1), Hardy L(1), Bakou A(1), Mahlberg J(2), Weidemann G(2)(3), Cashel
S(2), Moustafa AA(2)(3).
Author information:
(1)School of Psychology, University of Exeter, Exeter, United Kingdom.
(2)School of Social Sciences and Psychology, Western Sydney University, Sydney,
NSW, Australia.
(3)MARCS Institute for Brain, Behaviour and Development, Western Sydney
University, Sydney, NSW, Australia.
DOI: 10.3389/fpsyt.2019.00274
PMCID: PMC6529569
PMID: 31156470
Author information:
(1)Army Medical College, National University of Medical Sciences (NUMS),
Islamabad, Pakistan.
314. Health Policy Plan. 2016 Dec;31(10):1384-1390. Epub 2016 Jun 16.
Author information:
(1)Centre for Health and Social Change, London School of Hygiene and Tropical
Medicine, London, UK adrianna.murphy@lshtm.ac.uk.
(2)World Health Organization Office for Europe, Regional Office for Health
Systems Strengthening, Barcelona, Spain.
(3)Centre for Health and Social Change, London School of Hygiene and Tropical
Medicine, London, UK.
(4)European Centre on Health of Societies in Transition, London School of Hygiene
and Tropical Medicine, London, UK.
© The Author 2016. Published by Oxford University Press in association with The
London School of Hygiene and Tropical Medicine. All rights reserved. For
permissions, please e-mail: journals.permissions@oup.com.
DOI: 10.1093/heapol/czw080
PMID: 27315830 [Indexed for MEDLINE]
315. Version 2. F1000Res. 2018 Sep 3 [revised 2019 Feb 22];7:1392. doi:
10.12688/f1000research.15886.2. eCollection 2018.
Author information:
(1)Universidad San Ignacio de Loyola, Centro de Excelencia en Estudios Económicos
y Sociales en Salud, Lima, 15024, Peru.
(2)Universidad San Ignacio de Loyola, Unidad de Investigación para la Generación
y Síntesis de Evidencias en Salud, Lima, 15024, Peru.
(3)Universidad Nacional Mayor de San Marcos, Lima, 15081, Peru.
(4)Department of Clinical Epidemiology and Biostatistics, Pontificia Universidad
Javeriana, Bogota, 110311, Colombia.
DOI: 10.12688/f1000research.15886.2
PMCID: PMC6364375.2
PMID: 30800287
Author information:
(1)Department of Internal Medicine, General Hospital of Heraklion
"Venizeleio-Pananeio", Leoforos Knossou, Heraklion, 71409, Greece. Electronic
address: stamatiskarakonstantis@gmail.com.
(2)General Medicine, University Hospital of Heraklion, Heraklion, 71410, Greece.
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.jiph.2019.03.017
PMID: 30981652
Substance use and misuse in burn patients: Testing the classical hypotheses of
the interaction between post-traumatic symptomatology and substance use.
The authors aimed to test whether the three classical hypotheses of the
interaction between post-traumatic symptomatology and substance use (high risk of
trauma exposure, susceptibility for post-traumatic symptomatology, and
self-medication of symptoms), may be useful in the understanding of substance use
among burn patients. Substance use data (nicotine, alcohol, cannabis,
amphetamines, cocaine, opiates, and tranquilizers) and psychopathology measures
among burn patients admitted to a burn unit and enrolled in a longitudinal
observational study were analyzed. Lifetime substance use information (n = 246)
was incorporated to analyses aiming to test the high risk hypothesis. Only
patients assessed for psychopathology in a 6-month follow-up (n = 183) were
included in prospective analyses testing the susceptibility and self-medication
hypotheses. Regarding the high risk hypothesis, results show a higher proportion
of heroin and tranquilizer users compared to the general population. Furthermore,
in line with the susceptibility hypothesis, higher levels of symptomatology were
found in lifetime alcohol, tobacco, and drug users during recovery. The
self-medication hypothesis could be tested partially due to the hospital stay
"cleaning" effect, but severity of symptoms was linked to the amount of caffeine,
nicotine, alcohol, and cannabis use after discharge. It was found that the 3
classical hypotheses could be used to understand the link between traumatic
experiences and substance use explaining different patterns of burn patient's
risk for trauma exposure and emergence of symptomatology.
DOI: 10.1080/10550887.2015.1127717
PMID: 26670348 [Indexed for MEDLINE]
Author information:
(1)Civil Hospital Karachi, Dow University of Health Sciences, Karachi.
(2)Medical Student, Sind Medical College, Jinnah Sindh Medical University,
Karachi.
Reasons for cannabis use among youths at ultra high risk for psychosis.
Gill KE(1), Poe L, Azimov N, Ben-David S, Vadhan NP, Girgis R, Moore H, Cressman
V, Corcoran CM.
Author information:
(1)Columbia University, Department of Psychiatry, New York State Psychiatric
Institute, New York, New York, USA.
AIM: Cannabis use is prevalent in schizophrenia and its risk states, despite its
association with anxiety and positive symptoms. While schizophrenia patients
report using cannabis for mood enhancement and social motives, it is not known
what motivates clinical high risk (CHR) patients to use cannabis.
METHODS: Among 102 CHR patients, 24 (23%) endorsed cannabis use, and were queried
as to reasons for use, using a scale previously administered in schizophrenia
patients. We hypothesized a primary motivation for mood enhancement related to
anhedonia. We evaluated the 'self-medication' hypothesis by examining if
motivation for symptom relief was associated with concurrent severity of
symptoms.
RESULTS: The rank order of reasons for use in CHR patients was similar to that
previously reported by schizophrenia patients, with mood enhancement and social
motives as primary reasons for use, and the motivation to use cannabis for
symptom relief comparatively less common. Motivation for mood enhancement had a
trend association with anhedonia. Motivation for symptom relief was entirely
unrelated to concurrent severity of positive and anxiety symptoms.
CONCLUSION: As in schizophrenia, CHR patients primarily use cannabis for mood
enhancement, especially in the context of decreased motivation to seek pleasure
otherwise. Negative symptoms may drive cannabis use in schizophrenia and its risk
states, which may exacerbate positive symptoms. By contrast, CHR patients do not
report using cannabis to 'self-medicate' emergent positive symptoms. The
understanding of motives for cannabis use among CHR patients may be informative
for treatments aimed at reducing use, such as motivational interviewing.
DOI: 10.1111/eip.12112
PMCID: PMC4033707
PMID: 24274357 [Indexed for MEDLINE]
Sousa LAO(1), Fonteles MMF(1), Monteiro MP(1), Mengue SS(2), Bertoldi AD(3),
Pizzol TDSD(4), Tavares NUL(5), Oliveira MA(6), Luiza VL(6), Ramos LR(7), Farias
MR(8), Arrais PSD(1).
Author information:
(1)Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do
Ceará, Fortaleza, Brasil.
(2)Departamento de Medicina Social, Universidade Federal do Rio Grande do Sul,
Porto Alegre, Brasil.
(3)Departamento de Medicina Social, Universidade Federal de Pelotas, Pelotas,
Brasil.
(4)Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto
Alegre, Brasil.
(5)Faculdade de Ciências da Saúde, Universidade de Brasília, Brasília, Brasil.
(6)Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de
Janeiro, Brasil.
(7)Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo,
Brasil.
(8)Centro de Ciências da Saúde, Universidade Federal de Santa Catarina,
Florianópolis, Brasil.
The aim of this study was to describe the prevalence of adverse drug events
(ADEs) and associated factors reported by users of medicines in Brazil. This was
a cross-sectional population-based study conducted from September 2013 to
February 2014 with data from the Brazilian National Survey on Access, Use, and
Promotion of Rational Use of Medicines (PNAUM). The study included all
individuals that reported the use of medicines and identified, among them, all
those reporting at least one problem with the medicine's use. A descriptive
analysis was performed to estimate ADE prevalence and 95% confidence intervals
(95%CI) among the target variables. Crude and adjusted prevalence ratios were
calculated using Poisson regression to investigate factors associated with ADEs.
Overall ADE prevalence in Brazil was 6.6% (95%CI: 5.89-7.41), and after
multivariate analysis, higher prevalence was associated with female gender,
residence in the Central and Northeast regions, consumption of more medicines,
"bad" self-rated health, and self-medication. The drugs most frequently reported
with ADEs were fluoxetine, diclofenac, and amitriptyline. The most frequent ADEs
were somnolence, epigastric pain, and nausea. Most reported ADEs were mild,
avoidable, and associated with medicines used frequently by the population. The
study provided knowledge on the size of the problem with use of medicines in
Brazil.
Author information:
(1)Health Service Executive, Louth/Meath, Ireland.
(2)Chilliwack, British Columbia, Canada.
(3)Dublin North City and County CAMHS, Dublin, Ireland.
(4)Department of Public Health and Primary Care, Trinity College Dublin, Ireland;
Health Service Executive, Dublin, Ireland.
Aims and method We examined non-medical use (NMU) of olanzapine among adults on
methadone treatment. Information was collected on patient demographics and NMU of
olanzapine. The Alcohol, Smoking and Substance Involvement Screening Test
(ASSIST) was administered to assess risk among current users of olanzapine.
Results Ninety-two clients participated and 30% reported lifetime history of NMU
of olanzapine. Nine people reported doses of 30 mg or higher on a typical day of
use, with three typically using 100 mg. The most common reasons for use were to
relieve anxiety and to aid sleep, but a quarter used it to 'get stoned'. Eleven
participants (12%) reported NMU of olanzapine in the preceding month. Eight
completed the ASSIST with four scoring in the high-risk zone. Clinical
implications Self-medication is the dominant motivator for NMU of olanzapine, but
hedonic motivations also occur. A small minority show features of dependency. All
doctors should be aware of the potential NMU of olanzapine, especially among
patients with history of addiction.
DOI: 10.1192/pb.bp.115.052886
PMCID: PMC5353524
PMID: 28377810
Author information:
(1)Department of Family Medicine and Community Nursing, Medical University of
Białystok, Mieszka I 4B, 15-054, Białystok, Poland.
julia.strumilo@poczta.onet.pl.
(2)Department of Family Medicine and Community Nursing, Medical University of
Białystok, Mieszka I 4B, 15-054, Białystok, Poland.
(3)Department of Statistics and Medical Informatics, Medical University of
Białystok, Białystok, Poland.
DOI: 10.1186/s12875-016-0463-6
PMCID: PMC4891944
PMID: 27255505 [Indexed for MEDLINE]
323. Iran J Med Sci. 2014 Nov;39(6):584-8.
Pal A(1), Sen S(1), Das S(1), Biswas A(1), Tripathi SK(1).
Author information:
(1)Department of Clinical and Experimental Pharmacology, Calcutta School of
Tropical Medicine, Kolkata, West Bengal, India.
PMCID: PMC4242996
PMID: 25429184
324. J Anesth Perioper Med. 2017 Nov 28;4(6):274-281. Epub 2017 Nov 2.
Kim S(1)(2), Duncan PW(2)(3), Groban L(2)(4), Segal H(5), Abbott RM(3),
Williamson JD(1)(2).
Author information:
(1)Department of Internal Medicine, Winston-Salem, NC, USA.
(2)Sticht Center on Aging, Winston-Salem, NC, USA.
(3)Department of Neurology, Winston-Salem, NC, USA.
(4)Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem,
NC, USA.
(5)Fisher Center for Hereditary Cancer AND Clinical Genomics Research, Georgetown
University, Washington, D.C., USA.
PMCID: PMC5766034
PMID: 29333531
Sessa M(1), Sportiello L(1), Mascolo A(1), Scavone C(1), Gallipoli S(1), di Mauro
G(1), Cimmaruta D(1), Rafaniello C(1), Capuano A(1).
Author information:
(1)Section of Pharmacology "L. Donatelli", Department of Experimental Medicine,
Campania Pharmacovigilance and Pharmacoepidemiology Regional Centre, University
of Campania "Luigi Vanvitelli"Naples, Italy.
DOI: 10.3389/fphar.2017.00305
PMCID: PMC5445158
PMID: 28603499
Author information:
(1)Division of Community Healthcare and Pharmacy, Department of Healthcare and
Regulatory Sciences, School of Pharmacy, Showa University.
DOI: 10.1248/bpb.b16-00008
PMID: 27803447 [Indexed for MEDLINE]
327. Bull World Health Organ. 2018 Feb 1;96(2):141-144. doi: 10.2471/BLT.17.199687.
Epub 2018 Jan 10.
Author information:
(1)International Health Policy Program, Ministry of Public Health, Nonthaburi
11000, Thailand.
DOI: 10.2471/BLT.17.199687
PMCID: PMC5791781
PMID: 29403119 [Indexed for MEDLINE]
The social sciences within health care and pharmacy provide various points of
view on issues often managed by professionals both inside and outside of the
health care system. This multidisciplinary perspective often leads to divergent
views and sometimes seemingly contradictory viewpoints and solutions. This paper
is devoted to the opinions and attitudes of Czech citizens on selected issues of
healthcare and pharmacy, the elucidation of which could be a source for
understanding the relationships among participants in our pluralist health care
system as a whole. This article presents the results of a sociological survey
featuring a representative sample in terms of gender, age and region of 1,797
respondents from the Czech population aged 15 and over. The research is focused
on the issues of self-medication, choice of pharmacy, out of pocket expenditures
on prescription drugs and over-the-counter medicines, experiences with side
effects and finally an evaluation of patient comprehension of information
leaflets accompanying health care products. According to the results presented
here, at the onset of a health problem most of the population tries to treat the
condition themselves before seeing a doctor (54.1% always, 30.9% sometimes).
Over-the-counter drugs are purchased generally in classic pharmacies without
self-service (96.1%). The choice of pharmacy is determined primarily by
proximity, with much less importance placed on personal experience or lower
price. According to the survey, Czechs spend around 150 CZK (€ 5.9) for
over-the-counter medicines and around 143 CZK (€ 5.6) for prescription drugs per
month; 77.9% of Czech citizens were shown to understand the information provided
on package leaflets. These data help to understand the perception, orientation
and behavior of the patient in the healthcare system, with the ultimate goal of
leading to higher system effectiveness as well as greater satisfaction for all
parties involved.
Author information:
(1)Department of Health and Hospital Management,Aga Khan University, Karachi,
Pakistan.
(2)Institute of Business Management & Department of Medicine, Aga Khan
University, Karachi, Pakistan.
Factors associated with sedative use and misuse among heroin users.
Author information:
(1)Department of Psychiatry and Behavioral Neurosciences, School of Medicine,
Wayne State University, Detroit, MI 48201, USA.
(2)Department of Psychiatry and Behavioral Neurosciences, School of Medicine,
Wayne State University, Detroit, MI 48201, USA; Department of Pharmacy Practice,
Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University,
Detroit, MI 48201, USA. Electronic address: mgreen@med.wayne.edu.
BACKGROUND: Rates of both opioid and sedative use and misuse are rising. Comorbid
opioid and sedative use is associated with especially severe consequences (e.g.,
overdose and poor health outcomes). Heroin users report multiple motivations for
sedative use, including self-medication. We aimed to understand differences in
lifetime substance use characteristics between heroin users with different
sedative use histories.
METHODS: Substance use data were collected from 385 non-treatment seeking heroin
users. Subjects were divided into four lifetime sedative-use groups: no use,
medical use only, non-medical use only, and mixed medical and non-medical use. We
examined patterns of use of various substances of abuse (tobacco, alcohol,
marijuana, cocaine, heroin, and sedatives) and individual characteristics
associated with each.
RESULTS: Non-medical sedative use (alone or in addition to medical use) was
associated with more negative consequences from using all substances. Medical
sedative use alone was not related to increased overdose or emergency room visits
associated with heroin use. Non-medical sedative use was associated with
increases in 15 of the 21 measured heroin consequences and only one of those -
health problems - was also associated with medical sedative use.
CONCLUSIONS: Concomitant non-medical sedative use and heroin use is associated
with significantly greater negative outcomes than those experienced by heroin
users who report use of sedatives only as prescribed. Understanding these
differences offers insight into risks related to using both substances and may
help treatment providers create targeted harm reduction interventions for this
population.
DOI: 10.1016/j.drugalcdep.2017.11.035
PMCID: PMC5889740
PMID: 29413433 [Indexed for MEDLINE]
Foiadelli T(1), Piccorossi A(2), Sacchi L(3), De Amici M(4), Tucci M(5),
Brambilla I(4), Marseglia GL(4), Savasta S(4), Verrotti A(2).
Author information:
(1)Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University
of Pavia, Pediatric Clinic, I.R.C.C.S. Policlinico "S. Matteo" Foundation, 27100,
Pavia, Italy. thomas.foiadelli@gmail.com.
(2)Department of Pediatrics, University of L'Aquila, San Salvatore Hospital,
L'Aquila, Italy.
(3)Department of Electrical, Computer and Biomedical Engineering, University of
Pavia, Pavia, Italy.
(4)Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University
of Pavia, Pediatric Clinic, I.R.C.C.S. Policlinico "S. Matteo" Foundation, 27100,
Pavia, Italy.
(5)Laboratorio Adolescenza association, Pavia, Italy.
DOI: 10.1186/s13052-018-0486-9
PMCID: PMC5885291
PMID: 29618369 [Indexed for MEDLINE]
Author information:
(1)National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS,
Department of Epidemiology, Pre-clinical Research and Advanced Diagnostics, via
Portuense, 292, 00149, Roma, Italy.
(2)National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS,
Department of Epidemiology, Pre-clinical Research and Advanced Diagnostics, via
Portuense, 292, 00149, Roma, Italy. gabriella.decarli@inmi.it.
(3)Centre Hospitalier Universitaire de Nice, Service de Médecine Interne,
F-06200, Nice, France.
(4)Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and
Inflammation-Immunopathology-Biotherapy Department (DHU i2B), F-75005, Paris,
France.
(5)INSERM, UMR_S 959, F-75013, Paris, France.
(6)CNRS, FRE3632, F-75005, Paris, France.
(7)AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine
and Clinical Immunology, F-75013, Paris, France.
(8)Università degli Studi di Modena e Reggio Emilia, Infectious Diseases Clinics,
Modena, Italy.
DOI: 10.1186/s12879-017-2819-5
PMCID: PMC5704632
PMID: 29179700 [Indexed for MEDLINE]
State of the fight against informal market of medicines in Togo: approaches and
limitations.
Gnassingbe A(1), Flahault A(1), Geissbuhler A(2), Sprumont D(3), Awesso A(4).
Author information:
(1)Institut de santé globale, Faculté de médecine, Université de Genève, Suisse.
(2)Département de radiologie et informatique médicale, Faculté de médecine,
Université de Genève, Suisse.
(3)Institut de droit de la santé, Université de Neuchâtel, Neuchâtel, Suisse,
Swiss School of Public Health, Zurich, Suisse.
(4)Département d'Anthropologie, Université de Lomé, Togo.
The extent of medicines sales and consumption in the informal market in Togo
raises many ethical and public health issues. In order to report on the situation
of public action in the fight against this practice, we conducted a qualitative
survey from 15 to 25 February 2016 in the commune of Lomé and in the Maritime
Region among the actors of control system and resource people in the general
population. This was supplemented by an analysis of Togo's pharmaceutical and
health policy documents and a literature review on the illicit drug market issues
relating to public health, political science, the social sciences applied to
health. In spite of the existence of national and international tools, household
poverty, cultural self-medication, ignorance of the population concerning the
health risks of informal market medicines, weak political commitment, weakness
regulation and enforcement, corruption, constitute obstacles to the success of
actions to combat this practice.
DOI: 10.1684/mst.2018.0750
PMID: 29616645 [Indexed for MEDLINE]
334. Trop Med Health. 2015 Mar;43(1):11-9. doi: 10.2149/tmh.2014-19. Epub 2014 Oct
16.
Ilunga-Ilunga F(1), Levêque A(2), Ngongo LO(3), Laokri S(4), Dramaix M(2).
Author information:
(1)Institut Supérieur des Techniques Médicales de Kinshasa , RD Congo ;
Université Libre de Bruxelles, School of Public Health, Research Centre in
Epidemiology, Biostatistics and Clinical Research , Brussels, Belgium.
(2)Université Libre de Bruxelles, School of Public Health, Research Centre in
Epidemiology, Biostatistics and Clinical Research , Brussels, Belgium.
(3)Université Notre-Dame de Tshiumbe, Democratic Republic of Congo.
(4)Université Libre de Bruxelles, School of Public Health, Health Policies &
Systems Department , Brussels, Belgium.
BACKGROUND: In the Democratic Republic of Congo (DRC), few studies have focused
on treatment-seeking paths selected by caretakers for the management of severe
childhood malaria in an urban environment. The present study aims at describing
the treatment-seeking paths according to the characteristics of households, as
well as the subsequent impact on pre-hospitalisation delay and malarial fatality
and on the main syndromes associated with severe childhood malaria.
METHODS: This descriptive study included data collected at nine hospitals in
Kinshasa between January and November 2011. A total of 1,350 children, under 15
years of age and hospitalised for severe malaria, were included in the study.
RESULTS: Regarding the management of malaria, 31.5% of households went directly
to the health centre or hospital while 68.5% opted for self-medication, church
and/or traditional healing therapy. The most frequent first-line option was
self-medication, adopted by more than 61.5% of households. Nevertheless, rational
self-medication using antimalarial drugs recommended by the WHO
(artemisinin-based combinations) was reported for only 5.5% of children. Only
12.5% of households combined 2 or 3 traditional options. The following criteria
influenced the choice of a modern vs. traditional path: household socioeconomic
level, residential environment, maternal education level and religious beliefs.
When caretakers opted for traditional healing therapy, the pre-hospitalisation
delay was longer and the occurrence of respiratory distress, severe anaemia and
mortality was higher.
CONCLUSION: The implementation of a malaria action plan in the Democratic
Republic of Congo should take into account the diversity and pluralistic
character of treatment-seeking behaviours in order to promote the most
appropriate options (hospital and rational self-medication) and to avoid
detrimental outcomes.
DOI: 10.2149/tmh.2014-19
PMCID: PMC4317488
PMID: 25729313
Wilkinson AL(1), Halpern CT(2), Herring AH(3), Shanahan M(4), Ennett ST(5),
Hussey JM(2), Harris KM(6).
Author information:
(1)Carolina Population Center, University of North Carolina at Chapel Hill,
Chapel Hill, North Carolina; Department of Maternal and Child Health, Gillings
School of Global Public Health, University of North Carolina at Chapel Hill,
Chapel Hill, North Carolina. Electronic address: wilkina@live.unc.edu.
(2)Carolina Population Center, University of North Carolina at Chapel Hill,
Chapel Hill, North Carolina; Department of Maternal and Child Health, Gillings
School of Global Public Health, University of North Carolina at Chapel Hill,
Chapel Hill, North Carolina.
(3)Carolina Population Center, University of North Carolina at Chapel Hill,
Chapel Hill, North Carolina; Department of Biostatistics, Gillings School of
Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill,
North Carolina.
(4)Department of Maternal and Child Health, Gillings School of Global Public
Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;
Injury Prevention Research Center, University of North Carolina at Chapel Hill,
Chapel Hill, North Carolina.
(5)Department of Health Behavior, Gillings School of Global Public Health,
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
(6)Carolina Population Center, University of North Carolina at Chapel Hill,
Chapel Hill, North Carolina; Department of Sociology, University of North
Carolina at Chapel Hill, Chapel Hill, North Carolina.
PURPOSE: Both substance use and depression are common in adolescence and often
comorbid. Past research has produced conflicting results on whether there is a
temporal relationship, and if so, in which direction it operates and how it may
vary by sex. We examined the longitudinal associations between substance use
frequency and depressive symptoms from adolescence into young adulthood and
whether the associations were moderated by sex.
METHODS: With data from Waves I, III, and IV of the National Longitudinal Study
of Adolescent to Adult Health (n = 9,816), we used growth curve models to test if
depressive symptoms predicted marijuana use or binge drinking frequency
(Self-Medication Model) or if substance use frequency predicted depressive
symptoms (Stress Model). Moderation by sex and age was tested for both potential
pathways.
RESULTS: Increases in adolescent depressive symptoms, compared to no symptoms,
were associated with a steeper predicted increase in marijuana use frequency from
adolescence to young adulthood. Increases in persistent binge drinking or
marijuana use frequency had concurrent positive associations with depressive
symptoms from adolescence to young adulthood, and these associations were
significantly stronger for females compared to males.
CONCLUSIONS: The results not only support the Self-Medication Model for marijuana
use but also provide modest support for the Stress Model, that substance use is
associated with depressive symptoms, especially for females.
DOI: 10.1016/j.jadohealth.2016.07.010
PMCID: PMC5123943
PMID: 27567065 [Indexed for MEDLINE]
Symmes A(1), Winters KC(2), Fahnhorst T(2), Botzet A(2), Lee S(2), August G(2),
Realmuto G(2).
Author information:
(1)Augsburg College, Minneapolis, MN.
(2)University of Minnesota, Minneapolis, MN.
Previous research indicates that youth with ADHD are more susceptible to nicotine
use compared to those without ADHD and one explanation for this association is
the self-medication theory. The present study examines nicotine use in a
prospective sample derived from a community sampling procedure rather than a
clinical setting. Nicotine use was measured through young adulthood (mean ages:
18, 20 and 22) and three groups were compared based on childhood status:
ADHD-only, ADHD-extemalizers and control groups. Results indicated that at all
three data points, individuals with childhood ADHD plus an externalizing disorder
reported higher nicotine use on all variables compared to the ADHD group absent
of an externalizing disorder and the comparison group of non-ADHD youth. The
group differences were significant even after controlling for possible
confounding variables (age, gender, and current treatment with psychostimulant
medication). Study results are discussed in light of the self-medication
hypothesis and of the importance of including nicotine prevention programs for
adolescents and young adults with ADHD and externalizing problems.
DOI: 10.1080/1067828X.2012.756442
PMCID: PMC4306279
PMID: 25632218
337. Biomed Rep. 2017 May;6(5):539-544. doi: 10.3892/br.2017.888. Epub 2017 Apr 10.
Rosehip inhibits xanthine oxidase activity and reduces serum urate levels in a
mouse model of hyperuricemia.
Kikuchi H(1), Kogure S(1), Arai R(1), Saino K(1), Ohkubo A(2), Tsuda T(1), Sunaga
K(1).
Author information:
(1)Department of Clinical Dietetics and Human Nutrition, Faculty of
Pharmaceutical Sciences, Josai University, Sakado, Saitama 350-0295, Japan.
(2)Development Division, Ryusendo Co., Ltd., Toshimaku, Tokyo 171-0021, Japan.
Rosehip, the fruit of Rosa canina L., has traditionally been used to treat urate
metabolism disorders; however, its effects on such disorders have not been
characterized in detail. Therefore, the present study investigated the effects of
hot water, ethanol and ethyl acetate extracts of rosehip on xanthine oxidase (XO)
activity in vitro. In addition, the serum urate lowering effects of the rosehip
hot water extract in a mouse model of hyperuricemia (male ddY mice, which were
intraperitoneally injected with potassium oxonate) were investigated.
Furthermore, the influence of rosehip hot water extract on CYP3A4 activity, which
is the most important drug-metabolizing enzyme from a herb-drug interaction
perspective, was investigated. Rosehip extracts of hot water, ethanol and ethyl
acetate inhibited XO activity [half maximal inhibitory concentration (IC50)
values: 259.6±50.6, 242.5±46.2 and 1,462.8±544.2 µg/ml, respectively].
Furthermore, the administration of 1X rosehip hot water extract significantly
reduced the levels of serum urate at 8 h, which was similar when compared with
the administration of 1 mg/kg allopurinol. Rosehip hot water extract only
marginally affected CYP3A4 activity (IC50 value, >1 mg/ml). These findings
indicate that rosehip hot water extract may present as a functional food for
individuals with a high urate level, and as a therapeutic reagent for
hyperuricemic patients.
DOI: 10.3892/br.2017.888
PMCID: PMC5431748
PMID: 28529735
Meng H(1), Liao Q(2), Suen LK(1), O'Donoghue M(1), Wong CM(2), Yang L(3).
Author information:
(1)School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Hong Kong
Special Administrative Region (HKSAR), China.
(2)School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong
Special Administrative Region (HKSAR), China.
(3)School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Hong Kong
Special Administrative Region (HKSAR), China. l.yang@polyu.edu.hk.
DOI: 10.1186/s12879-016-1821-7
PMCID: PMC5029067
PMID: 27646778 [Indexed for MEDLINE]
Kim JH(1), Chung CH, Lau CH, Goggins WB, Lau JT, Griffiths SM.
Author information:
(1)The Jockey Club School of Public Health & Primary Care, The Chinese University
of Hong Kong.
Author information:
(1)Associate Fellow, Observer Research Foundation, New Delhi, India.
(2)Population Research Centre, Institute of Economic Growth, Delhi University
North Campus, Delhi, India.
AYUSH, an acronym for Ayurveda, Yoga and Naturopathy, Unani, Siddha, Sowa-Rigpa
and Homeopathy represents the alternative systems of medicine recognized by the
Government of India. Understanding the patterns of utilization of AYUSH care has
been important for various reasons including an increased focus on its
mainstreaming and integration with biomedicine-based health care system. Based on
a nationally representative health survey 2014, we present an analysis to
understand utilization of AYUSH care across socioeconomic and demographic groups
in India. Overall, 6.9% of all patients seeking outpatient care in the reference
period of last two weeks have used AYUSH services without any significant
differentials across rural and urban India. Importantly, public health facilities
play a key role in provisioning of AYUSH care in rural areas with higher
utilization in Chhattisgarh, Kerala and West Bengal. Use of AYUSH among
middle-income households is lower when compared with poorer and richer
households. We also find that low-income households display a greater tendency
for AYUSH self-medication. AYUSH care utilization is higher among patients with
chronic diseases and also for treating skin-related and musculo-skeletal
ailments. Although the overall share of AYUSH prescription drugs in total medical
expenditure is only about 6% but the average expenditure for drugs on AYUSH and
allopathy did not differ hugely. The discussion compares our estimates and
findings with other studies and also highlights major policy issues around
mainstreaming of AYUSH care.
DOI: 10.1371/journal.pone.0176916
PMCID: PMC5417584
PMID: 28472197 [Indexed for MEDLINE]
Dantas DNA(1), Enders BC(1), Oliveira DRC(1), Vieira CENK(1), Queiroz AAR(2),
Arcêncio RA(2).
Author information:
(1)Universidade Federal do Rio Grande do Norte, Postgraduate Program in Nursing.
Natal, Rio Grande do Norte, Brazil.
(2)Universidade de São Paulo, Ribeirão Preto College of Nursing, Nursing Doctoral
Interunits Undergraduate Program. Ribeirão Preto, São Paulo, Brazil.
DOI: 10.1590/0034-7167-2016-0680
PMID: 29562023 [Indexed for MEDLINE]
342. J Trauma Stress. 2018 Aug;31(4):602-612. doi: 10.1002/jts.22304. Epub 2018 Jul
20.
The Indirect Effect of Posttraumatic Stress Disorder Symptoms on Current Alcohol
Use Through Negative Cognitions in Sexual Minority Men.
Banerjee N(1), Ironson G(1), Fitch C(1), Boroughs MS(2), Safren SA(1), Powell
A(3), O'Cleirigh C(4).
Author information:
(1)Department of Psychology, University of Miami, Coral Gables, Florida, USA.
(2)Department of Psychology, University of Windsor, Windsor, Canada.
(3)Miller School of Medicine, University of Miami, Miami, Florida, USA.
(4)Department of Psychiatry, Harvard Medical School/Massachusetts General
Hospital, Boston, Massachusetts, USA.
Self-medication theory posits that some trauma survivors use alcohol to cope with
posttraumatic stress disorder (PTSD) symptoms, but the role of negative
posttraumatic cognitions in this relationship is not well defined. We examined
associations among PTSD symptoms, posttraumatic cognitions, and alcohol
intoxication frequency in 290 men who have sex with men (MSM), who reported a
history of childhood sexual abuse (CSA). Using a bootstrap approach, we examined
the indirect effects of PTSD symptoms on alcohol intoxication frequency through
posttraumatic cognitions regarding the self, world, and self-blame. In separate
regression models, higher levels of PTSD symptoms and posttraumatic cognitions
were each associated with more frequent intoxication, accounting for 2.6% and
5.2% of the variance above demographics, respectively. When examined
simultaneously, posttraumatic cognitions remained significantly correlated with
intoxication frequency whereas PTSD symptoms did not. Men reporting elevated
posttraumatic cognitions faced increased odds for current alcohol dependence,
odds ratio (OR) = 2.19, 95% CI [1.13, 4.22], compared with men reporting low
posttraumatic cognitions, independent of current PTSD diagnosis. A higher level
of PTSD symptom severity was indirectly associated with more frequent alcohol
intoxication through cognitions about the self and world; the indirect to total
effect ratios were 0.74 and 0.35, respectively. Negative posttraumatic cognitions
pertaining to individuals' self-perceptions and appraisals of the world as
dangerous may play a role in self-medication with alcohol among MSM with a
history of CSA. Interventions targeting these cognitions may offer potential for
reducing alcohol misuse in this population, with possible broader implications
for HIV-infection risk.
DOI: 10.1002/jts.22304
PMCID: PMC6286675
PMID: 30028033
Author information:
(1)RTI International, Research Triangle Park, 3040 East Cornwallis Road, NC
27709, United States. Electronic address: snovak@rti.org.
(2)RTI International, Research Triangle Park, 3040 East Cornwallis Road, NC
27709, United States. Electronic address: npeiper@rti.org.
(3)RTI International, Research Triangle Park, 3040 East Cornwallis Road, NC
27709, United States. Electronic address: gaz@rti.org.
BACKGROUND: This study examined poly-drug use involving the use of cannabis with
nonmedical prescription pain reliever use (NMPR) and alcohol use.
METHODS: Computer-assisted survey data from the National Survey on Drug Use and
Health were examined. The NSDUH is an annual, cross-sectional survey of
non-institutionalized citizens in the United States (ages 12+). Replicate
analyses were conducted using the 2013 and 2003 survey waves.
RESULTS: Higher levels of cannabis use were consistently associated with more
frequent consumption of prescription pain relievers, with findings replicating in
both 2013 and 2003. While the prevalence of dual users declined from 2003 (2.5%)
to 2013 (2.3%), the average number of days used among dual users increased by an
average of 20 days over that period. These changes largely occurred among those
aged 35 or older, males, whites, and non-illicit drug users. Past-year marijuana
use increased by 16% (10.8-12.6%, p-value<.001) whereas NMPR decreased by 15%
(4.9-4.2%, p-value<.001). The largest changes occurred after 2011. Persons using
the most cannabis generally had higher levels of alcohol use relative to those
using the least amount of cannabis. There was a significant increase in the
prevalence of dual use between 2003 (10.2%) and 2013 (11.6%), while the
prevalence of past-year alcohol use remained relatively stable.
CONCLUSIONS: Clinical efforts and public health interventions should consider the
possible co-ingestion of cannabis with NMPR and alcohol, as concomitant use may
portend negative health effects in the short and long-term.
DOI: 10.1016/j.drugalcdep.2015.11.039
PMCID: PMC4739852
PMID: 26748409 [Indexed for MEDLINE]
Bentele-Jaberg N(1), Guenova E, Mehra T, Nägeli M, Chang YT, Cozzio A, French LE,
Hoetzenecker W.
Author information:
(1)Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.
We describe the case of a 32-year-old woman who presented to the hospital with
generalized painful exanthema, blisters and erosions 1 month after giving birth
to a healthy girl. The patient's medical history was inconspicuous for
comorbidities; however, it included the incidental intake of pain killers and a
herbal preparation (fenugreek), which she took regularly over the last 4 weeks to
improve lactation. Based on the clinical characteristics, we suspected toxic
epidermal necrolysis (TEN), a severe cutaneous adverse drug reaction, which was
confirmed by skin biopsy. The patient was treated with high-dose intravenous
human immunoglobulins and was discharged 2 weeks after hospital admission in good
condition. The allergological workup identified fenugreek as the most likely
causative agent. Given the increased self-medication of freely available
phytotherapeutics by patients in industrialized countries, herbal mixtures should
be taken into consideration in the diagnostic workup of TEN.
DOI: 10.1159/000433423
PMID: 26138328 [Indexed for MEDLINE]
345. Int J Drug Policy. 2018 Aug;58:64-70. doi: 10.1016/j.drugpo.2018.05.004. Epub
2018 May 26.
Rowe C(1), Wheeler E(2), Vittinghoff E(3), Santos GM(4), Behar E(5), Coffin
PO(6).
Author information:
(1)San Francisco Department of Public Health, 25 Van Ness Avenue, Suite 500, San
Francisco, CA 94102, USA. Electronic address: chris.rowe@sfdph.org.
(2)Harm Reduction Coalition, 1440 Broadway, Suite 902, Oakland, CA 94612, USA.
Electronic address: wheeler@harmreduction.org.
(3)University of California, San Francisco, 500 Parnassus Avenue, San Francisco,
CA 94143, USA. Electronic address: eric.vittinghoff@ucsf.edu.
(4)San Francisco Department of Public Health, 25 Van Ness Avenue, Suite 500, San
Francisco, CA 94102, USA; University of California, San Francisco, 500 Parnassus
Avenue, San Francisco, CA 94143, USA. Electronic address:
glenn-milo.santos@sfgov.org.
(5)San Francisco Department of Public Health, 25 Van Ness Avenue, Suite 500, San
Francisco, CA 94102, USA. Electronic address: emily.behar@sfdph.org.
(6)San Francisco Department of Public Health, 25 Van Ness Avenue, Suite 500, San
Francisco, CA 94102, USA; University of California, San Francisco, 500 Parnassus
Avenue, San Francisco, CA 94143, USA. Electronic address:
phillip.coffin@sfdph.org.
DOI: 10.1016/j.drugpo.2018.05.004
PMCID: PMC6419728
PMID: 29807248 [Indexed for MEDLINE]
346. J Clin Pharm Ther. 2017 Jun;42(3):370-371. doi: 10.1111/jcpt.12511. Epub 2017
Mar
1.
Author information:
(1)Department of Pharmacy Practice, Center for Health Outcomes Research and
Education, St. Louis College of Pharmacy, St. Louis, MO, USA.
(2)Mercy Clinic Internal Medicine and Geriatrics - Old Tesson, St. Louis, MO,
USA.
(3)Division of Geriatrics and Nutritional Science, Department of Internal
Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO,
USA.
DOI: 10.1111/jcpt.12511
PMCID: PMC5516898
PMID: 28251653 [Indexed for MEDLINE]
347. Afr J Prim Health Care Fam Med. 2015 May 5;7(1). doi: 10.4102/phcfm.v7i1.735.
Author information:
(1)Department of Preventive Medicine and Primary Care, College of Medicine,
University of Ibadan. davidsonone@yahoo.com.
DOI: 10.4102/phcfm.v7i1.735
PMCID: PMC4564905
PMID: 26245600 [Indexed for MEDLINE]
Knowledge, attitude and practice towards antibiotic use among the public in
Kuwait.
Author information:
(1)Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University,
Kuwait City, Kuwait.
(2)Ministry of Health, Kuwait City, Kuwait.
DOI: 10.1371/journal.pone.0117910
PMCID: PMC4326422
PMID: 25675405 [Indexed for MEDLINE]
Author information:
(1)Department Economics and Sociology of Sport, Faculty of Human Sciences and
Economics, Saarland University, Saarbrücken, Germany.
In cooperation with the Sports Association of the Palatinate (SBP), a survey was
conducted on substance use by recreational and amateur athletes. Distribution of
the online questionnaire took place by means of chain-referral sampling, and
questions on substance use were presented using the randomized response technique
(RRT) to protect the anonymity of respondents and prevent socially desirable
answers. The estimated lowest limit for the population share for use of
prohibited substances during the last season (4%) and for lifetime use (3.6%) did
not differ significantly. Approximately 21% of respondents had used substances
for training or competitions that were taken for a purpose other than performance
enhancement (e.g., to improve their mood or to help with recuperation from a
minor injury or illness) in the last year. 49% had done so at some point in their
life.
DOI: 10.1371/journal.pone.0165103
PMCID: PMC5082616
PMID: 27783664 [Indexed for MEDLINE]
AlKhamees OA(1), AlNemer KA(2), Bin Maneea MW(3), AlSugair FA(4), AlEnizi BH(5),
Alharf AA(6).
Author information:
(1)Department of Pharmacology, College of Medicine, Al Imam Mohammad Ibn Saud
Islamic University (IMSIU), P.O. Box 11623, Riyadh 11544, Saudi Arabia.
(2)Department of Medicine, College of Medicine, Al Imam Mohammad Ibn Saud Islamic
University (IMSIU), P.O. Box 11623, Riyadh 11544, Saudi Arabia.
(3)Ophthalmology Resident, Ophthalmology Dep., Security Forces Hospital (SFH),
Riyadh, Saudi Arabia.
(4)Radiology Resident, Radiology Dep., King Faisal Specialist Hospital and
Research Cente (KFSHRC), Riyadh, Saudi Arabia.
(5)Orthopaedic Resident, Orthopaedics Dep., King Saud Medical City (KSMC),
Riyadh, Saudi Arabia.
(6)Saudi Food and Drug Authority, Riyadh, Saudi Arabia.
DOI: 10.1016/j.jsps.2017.12.009
PMCID: PMC6111197
PMID: 30166918
351. World J Oncol. 2016 Feb;7(1):17-20. doi: 10.14740/wjon957w. Epub 2016 Apr 3.
Author information:
(1)Department of Surgery, University of Utah, 50 North Medical Drive, Salt Lake
City, UT, USA.
(2)Center for Medical Innovation, University of Utah, 10 North 1900 East, Eccles
Library, Room 15, Salt Lake City, UT 84132, USA.
Pancreatic cancer is the fourth leading cause of cancer deaths in the United
States, and is considered uniformly fatal when patients present with
unresectable, advanced-stage disease at the time of diagnosis. Long-term survival
of patients with advanced-stage pancreatic adenocarcinoma remains rare, despite
advances in adjuvant chemoradiation protocols. A 73-year-old male presented to
our emergency department with abdominal pain and a history of biopsy-proven,
stage III pancreatic adenocarcinoma. His initial staging CT scan and
trans-duodenal ultrasound had demonstrated a stage IIa (T3, N0, Mx) lesion. On
surgical exploration, he was up-staged to stage III (T4, N0, Mx), noting
encasement of the superior mesenteric vessels and involvement of the portal vein.
He underwent palliative choledochojejunostomy and was treated with 4 months of
oxaliplatin and capecitabine, with concurrent radiation therapy (50.4 Gy),
followed by 4 months of gemcitabine. After 7 months, the patient withdrew from
therapy due to treatment intolerance. He then turned to self-medication with
non-traditional herbal therapies. After 3 years of surveillance, he was lost to
follow-up until presenting to our facility with abdominal pain 8 years after his
initial diagnosis. On diagnostic CT scan during his current presentation for
abdominal pain, he was found to have no evidence of pancreatic cancer. Based on
our review of the literature, we present the longest known survival of a patient
with surgically unresectable pancreatic adenocarcinoma. Further study of this
patient's phenotypic or genotypic characteristics may provide insight into better
therapeutic agents, or a predictive subset of patients who will benefit from
specific chemotherapeutic options.
DOI: 10.14740/wjon957w
PMCID: PMC5624684
PMID: 28983358
352. Rural Remote Health. 2018 Aug;18(3):4393. doi: 10.22605/RRH4393. Epub 2018 Aug
15.
Author information:
(1)Graduate School of Health, University of Technology Sydney, NSW, Australia
riana.rahmawati@uii.ac.id.
(2)Graduate School of Health, University of Technology Sydney, NSW, Australia
beata.bajorek@uts.edu.au.
DOI: 10.22605/RRH4393
PMID: 30107749 [Indexed for MEDLINE]
Author information:
(1)Centre Hospitalier Universitaire de Fann, Université Cheikh Anta Diop de
Dakar, Sénégal. sylviediop@gmail.com.
DOI: 10.3855/jidc.4957
PMID: 25313616 [Indexed for MEDLINE]
Author information:
(1)Department of Psychology, Federal University of Paraiba, João Pessoa, Brazil.
(2)Perception, Neuroscience and Behavior Laboratory, Federal University of
Paraiba, João Pessoa, Brazil.
DOI: 10.3389/fpsyg.2018.00288
PMCID: PMC5845747
PMID: 29559947
Author information:
(1)Department of Sociology, University of Copenhagen and SFI - The Danish
National Centre for Social Research, Copenhagen, Denmark.
(2)SFI - The Danish National Centre for Social Research, Copenhagen, Denmark.
This article analyses how young people enrolled in drug addiction treatment in
Copenhagen, Denmark, explain their cannabis careers and how they view their
possibilities for quitting drug use again. Inspired by Mead and narrative studies
of health and illness, the article identifies four different drug use
'aetiologies' drawn upon by the interviewees. These cover childhood experiences,
self-medication, the influence of friends and cannabis use as a specific
lifestyle. A central argument of the article is that these explanations not only
concern the past but also point towards the future by assigning the interviewee a
more or less agential position in relation to drugs. Further, the drug narratives
are viewed as interactional achievements, related to the social context in which
they were produced, namely, the institutional setting of the treatment centres.
The article is based on 30 qualitative interviews with young people in drug
addiction treatment.
© 2015 The Authors. Sociology of Health & Illness published by John Wiley & Sons
Ltd on behalf of Foundation for SHIL.
DOI: 10.1111/1467-9566.12239
PMCID: PMC4690517
PMID: 25688710 [Indexed for MEDLINE]
Inappropriate Use of Antibiotics and Its Associated Factors among Urban and Rural
Communities of Bahir Dar City Administration, Northwest Ethiopia.
DOI: 10.1371/journal.pone.0138179
PMCID: PMC4574735
PMID: 26379031 [Indexed for MEDLINE]
Author information:
(1)Nathan D. L. Smith, A.L.M., is a doctoral student in the Department of
Epidemiology, University of Florida, Gainesville, Florida. Linda B. Cottler,
Ph.D., M.P.H., F.A.C.E., is the dean's professor in the Department of
Epidemiology, University of Florida, Gainesville, Florida.
For more than 40 years, research has shown that individuals with post-traumatic
stress disorder (PTSD) use alcohol and experience alcohol use disorder (AUD) to a
greater degree than those with no PTSD. AUD and PTSD have shown a durable
comorbidity that has extended through decades and through changes in disorder
definitions. Some research shows that veterans who have experienced PTSD have a
high likelihood of developing AUD, perhaps reflecting the self-medication
hypothesis. Other research shows that people with substance use disorder are
likely to be exposed to traumatic situations and develop PTSD. These two areas of
research could represent two separate relationships between PTSD and AUD.
Finally, there is still no clear determination of which cluster of PTSD symptoms
is most closely associated with AUD.
PMCID: PMC6561398
PMID: 31198651
358. Am J Addict. 2015 Sep;24(6):532-7. doi: 10.1111/ajad.12257. Epub 2015 Aug 18.
Tucker D(1), Milloy MJ(1)(2), Hayashi K(1)(2), Nguyen P(1)(2), Kerr T(1)(2), Wood
E(1)(2).
Author information:
(1)British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital,
Vancouver, BC, Canada.
(2)Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
DOI: 10.1111/ajad.12257
PMCID: PMC4576827
PMID: 26282339 [Indexed for MEDLINE]
Author information:
(1)Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King
Faisal University, Alahsa, Saudi Arabia.
(2)School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500
Bandar Sunway, Selangor Darul Ehsan, Malaysia.
DOI: 10.1016/j.jsps.2014.02.014
PMCID: PMC4281610
PMID: 25561868
Author information:
(1)Department of Pharmacy, College of Health Sciences, Mekelle University, P.O.
Box 1871, Mekelle, Ethiopia.
Background: It is estimated that more than half of all women in adolescence age
suffer from dysmenorrhea and it often interferes with their daily physical and
emotional aspects. It is the leading cause of short-term school absenteeism and
is associated with a negative impact on academic and daily activities.
Objectives: To investigate impacts of dysmenorrhea, factors associated with it,
and its self-management strategies used by health science students.
Methods: A cross-sectional institution based study was conducted among 246
Mekelle University health science students selected by stratified random sampling
technique. Data were collected using self-administered semistructured
questionnaire. Data were analyzed using SPSS 16.
Results: The prevalence of dysmenorrhea was 71.8%. Participants who had long
menstrual cycle interval, long menses flows, and positive family history and who
were alcohol users were more likely to had dysmenorrhea. Participants reported
that 28.6% feel depressed, 16.2% are absent from class, and 22.9% had poor
personal relationship due to dysmenorrhea and 78.2% of them practiced
self-medication.
Conclusion: Dysmenorrhea is common among Mekelle University health science
students and it is major problem representing the cause of feeling depressed,
poor personal relationship, and class absenteeism. Majority of the study
participants used self-medication to treat dysmenorrhea.
DOI: 10.1155/2018/9730328
PMCID: PMC5828460
PMID: 29610764
Author information:
(1)Post Graduate, Department of Pharmacology, Vydehi Institute of Medical
Sciences & Research Centre , Bangalore, India .
(2)Technical Associate, Pharmacovigilance Unit, Vydehi Institute of Medical
Sciences & Research Centre , Bangalore, India .
(3)Professor, Department of Pharmacology, Head, Pharmacovigilance Unit, Vydehi
Institute of Medical Sciences & Research Centre , Bangalore, India .
(4)Professor and Head, Department of Pulmonary Medicine, Vydehi Institute of
Medical Sciences & Research Centre , Bangalore, India .
Corticosteroids are among the effective treatments available for many medical
conditions. Adverse effects such as osteoporosis, cataract and muscle weakness
are widely recognized on long term administration and have considerable public
health implications. Many reports are available that have dealt with individual
adverse effects.Here, we report a case of a 55-year-old female, with systemic
glucocorticoid induced bilateral cataract, osteoporosis, diabetes mellitus and
hypothalamic pituitary axis (HPA) suppression. These were induced through self
-medication. She presented to the hospital for the treatment of acute
exacerbation of bronchial asthma.
DOI: 10.7860/JCDR/2015/12110.5939
PMCID: PMC4484083
PMID: 26155491
362. Am J Trop Med Hyg. 2016 Oct 5;95(4):897-901. Epub 2016 Jul 25.
Vygen S(1), Tiffany A(2), Rull M(3), Ventura A(3), Wolz A(3), Jambai A(4), Porten
K(5).
Author information:
(1)French Institute of Public Health Surveillance, Alerts and Regions
Coordination Department, Regional office in Aquitaine, Bordeaux, France. European
Program for Intervention Epidemiology Training (EPIET), European Centre for
Disease Prevention and Control (ECDC), Stockholm, Sweden. Robert Koch-Institut,
Berlin, Germany.
(2)Epicentre, Geneva, Switzerland. amanda.tiffany@geneva.msf.org.
(3)Médecins Sans Frontières, Geneva, Switzerland.
(4)Sierra Leone Ministry of Health and Sanitation, Freetown, Sierra Leone.
(5)Epicentre, Paris, France.
Little is known about the residual effects of the west African Ebola virus
disease (Ebola) epidemic on non-Ebola mortality and health-seeking behavior in
Sierra Leone. We conducted a retrospective household survey to estimate mortality
and describe health-seeking behavior in Western Area, Sierra Leone, between May
25, 2014, and February 16, 2015. We used two-stage cluster sampling, selected 30
geographical sectors with probability proportional to population size, and
sampled 30 households per sector. Survey teams conducted face-to-face interviews
and collected information on mortality and health-seeking behavior. We calculated
all-cause and Ebola-specific mortality rates and compared health-seeking behavior
before and during the Ebola epidemic using χ2 and Fisher's exact tests.
Ninety-six deaths, 39 due to Ebola, were reported in 898 households. All-cause
and Ebola-specific mortality rates were 0.52 (95% confidence interval [CI] =
0.29-0.76) and 0.19 (95% CI = 0.01-0.38) per 10,000 inhabitants per day,
respectively. Of those households that reported a sick family member during the
month before the survey, 86% (73/85) sought care at a health facility before the
epidemic, compared with 58% (50/86) in February 2015 (P = 0.013). Reported
self-medication increased from 4% (3/85) before the epidemic to 23% (20/86)
during the epidemic (P = 0.013). Underutilization of health services and
increased self-medication did not show a demonstrable effect on non-Ebola-related
mortality. Nevertheless, the residual effects of outbreaks need to be taken into
account for the future. Recovery efforts should focus on rebuilding both the
formalized health system and the population's trust in it.
DOI: 10.4269/ajtmh.16-0295
PMCID: PMC5062797
PMID: 27458039 [Indexed for MEDLINE]
Author information:
(1)Department of Obstetrics & Gynaecology, Seth G S Medical College and KEM
Hospital, Parel, Mumbai, 400012 India.
DOI: 10.1007/s13224-015-0673-1
PMCID: PMC4912486
PMID: 27382216
Gabriel OT(1).
Author information:
(1)Department of Ear, Nose and Throat Surgery, Federal Medical Centre, Ido Ekiti,
Nigeria.
DOI: 10.4103/0300-1652.171620
PMCID: PMC4743287
PMID: 26903695
Community pharmacists' services for women during pregnancy and breast feeding in
Kuwait: a cross-sectional study.
Author information:
(1)Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University,
Kuwait.
© Article author(s) (or their employer(s) unless otherwise stated in the text of
the article) 2018. All rights reserved. No commercial use is permitted unless
otherwise expressly granted.
DOI: 10.1136/bmjopen-2017-018980
PMCID: PMC5780848
PMID: 29306891 [Indexed for MEDLINE]
Conflict of interest statement: Competing interests: None declared.
Author information:
(1)Global Health, Economics and Policy, Faculty of Medical Sciences, University
of Kragujevac, Kragujevac, Serbia.
(2)Faculty of Pharmacy, Arab International University, Daraa, Syria.
(3)Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac,
Kragujevac, Serbia.
(4)Faculty of Business Administration, Arab International University, Daraa,
Syria.
Pharmaceutical sector of Syrian Arab Republic before the war was characterized by
bold and successful development since the late 1980s. With the beginning of war
in the country back in March 2011, momentum has changed significantly.
Traumatism, communicable diseases related to morbidity and mortality as well as
wound infections became particularly hot public health concern. This relates not
only to the direct victims of military conflict but also to the displaced
civilians, refugees, and ordinary citizens alike. Evolving legislative framework
in Syria since 1980s tolerated dispensing of antibiotics without appropriate
prescription. Such practice led to spreading of antibiotic resistance among the
local bacteria frequently causing both community-acquired and nosocomial
infections. Laboratory findings of resistant bacteria strains among the Syrian
refugees in some European countries serve as evidence of concern spreading far
beyond Middle East. Practice of self-diagnosis and self-medication with
antibiotics by patients themselves and restraint to pharmacist advice is
widespread. A number of recommendations is presented to stakeholders to compact
antibiotic resistance after the peace is established in the country. The
successful implementation of such recommendations is the way to preserve
shrinking golden reserve of highly potent antibiotics as it is the last defense
line against resistant bacterial strains causing severe life-threatening
infections.
DOI: 10.3389/fpubh.2018.00212
PMCID: PMC6084506
PMID: 30116726
Knowledge and perceptions on antibiotic use and resistance among high school
students and teachers in New Delhi, India: A qualitative study.
Author information:
(1)Department of Pharmacology, V. P. Chest Institute, New Delhi, India.
(2)Department of Microbiology, Sir Ganga Ram Hospital, New Delhi, India.
(3)Department of Anthropology, University of Delhi, New Delhi, India.
(4)Department of Essential Drugs and other Medicines, South East Asia Regional
Office, WHO, New Delhi, India.
DOI: 10.4103/0253-7613.186208
PMCID: PMC4980922
PMID: 27756945 [Indexed for MEDLINE]
It's a Matter of Trust: Older African Americans Speak About Their Health Care
Encounters.
Author information:
(1)The Johns Hopkins University School of Nursing, Baltimore, MD, USA.
(2)The Johns Hopkins University School of Nursing, Baltimore, MD, USA
lgitlin1@jhu.edu.
DOI: 10.1177/0733464815570662
PMCID: PMC4530080
PMID: 25669876 [Indexed for MEDLINE]
Author information:
(1)Department of Pharmacy Practice, College of Clinical Pharmacy, Imam
Abdulrahman Bin Faisal University, Dammam, 31952, Saudi Arabia.
f.k.alhomoud@gmail.com.
(2)College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam,
Saudi Arabia.
DOI: 10.1186/s12889-018-6088-z
PMCID: PMC6192199
PMID: 30326870 [Indexed for MEDLINE]
Muhindo Mavoko H(1)(2), Ilombe G(3), Inocêncio da Luz R(4), Kutekemeni A(5), Van
geertruyden JP(6), Lutumba P(7).
Author information:
(1)Département de Médecine Tropicale, Université de Kinshasa, B.P. 747, Kin XI,
Kinshasa, République Démocratique du Congo. mavoko@yahoo.com.
(2)International Health Unit, Department of Epidemiology, University of Antwerp,
Campus Drie Eiken, Universiteitsplein 1, 2610, Kinshasa, République Démocratique
du Congo. mavoko@yahoo.com.
(3)Département de Médecine Tropicale, Université de Kinshasa, B.P. 747, Kin XI,
Kinshasa, République Démocratique du Congo. gillonilombe@yahoo.fr.
(4)International Health Unit, Department of Epidemiology, University of Antwerp,
Campus Drie Eiken, Universiteitsplein 1, 2610, Kinshasa, République Démocratique
du Congo. raquel.daluz@uantwerpen.be.
(5)Programme National de Lutte contre le Paludisme, Ministère de la Santé
Publique, Kinshasa, République Démocratique du Congo. albkutek@yahoo.fr.
(6)International Health Unit, Department of Epidemiology, University of Antwerp,
Campus Drie Eiken, Universiteitsplein 1, 2610, Kinshasa, République Démocratique
du Congo. jean-pierre.vangeertruyden@uantwerpen.be.
(7)Département de Médecine Tropicale, Université de Kinshasa, B.P. 747, Kin XI,
Kinshasa, République Démocratique du Congo. pascal_lutumba@yahoo.fr.
DOI: 10.1186/s12889-015-1670-0
PMCID: PMC4396810
PMID: 25885211 [Indexed for MEDLINE]
371. Adv Clin Exp Med. 2016 Mar-Apr;25(2):349-60. doi: 10.17219/acem/58887.
Author information:
(1)Department of Public Health, Faculty of Health Science, Wroclaw Medical
University, Poland.
DOI: 10.17219/acem/58887
PMID: 27627570 [Indexed for MEDLINE]
Tavares AI(1).
Author information:
(1)Center of Study and Research in Health/Centro de Estudos e Investigação em
Saúde (CEISUC), University of Coimbra, Coimbra, Portugal.
Comment in
Int J Health Policy Manag. 2015 Sep;4(9):625-6.
Int J Health Policy Manag. 2015;4(12):835.
Int J Health Policy Manag. 2016 Jan;5(1):77-8.
DOI: 10.15171/ijhpm.2015.45
PMCID: PMC4380566
PMID: 25844385
Author information:
(1)Internal Medicine, Icahn School of Medicine at Mount Sinai/Queen Hospital
Center, New York, USA.
(2)Internal Medicine, Icahn School of Medicine, Mount Sinai/Queens Hospital
Center, New York, USA.
(3)Research, California Institute of Behavioral Neurosciences & Psychology,
Sacramento, USA.
(4)Endocrinology, Icahn School of Medicine at Mount Sinai Queen Hospital Center,
New York, USA.
(5)Internal Medicine, Icahn School of Medicine at Mount Sinai/Queens Hospital
Center, New York, USA.
DOI: 10.7759/cureus.2965
PMCID: PMC6135297
PMID: 30210953
Author information:
(1)Kilimanjaro Christian Medical University College, P.O. Box 2240 Moshi,
Tanzania.
(2)Institute of Public Health, Kilimanjaro Christian Medical University College,
P.O. Box 2240 Moshi, Tanzania.
DOI: 10.11604/pamj.2018.31.165.15991
PMCID: PMC6492205
PMID: 31086618 [Indexed for MEDLINE]
Author information:
(1)Research Division, Federal Institute for Drugs and Medical Devices,
Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany.
katharina.schneider@bfarm-research.de.
(2)Centre for Translational Medicine, Medical Faculty of the University of Bonn,
Sigmund-Freud-Str. 25, 53127, Bonn, Germany.
katharina.schneider@bfarm-research.de.
(3)Institute of General Practice and Family Medicine, Medical Faculty of the
University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.
(4)Research Division, Federal Institute for Drugs and Medical Devices,
Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany.
(5)Centre for Translational Medicine, Medical Faculty of the University of Bonn,
Sigmund-Freud-Str. 25, 53127, Bonn, Germany.
DOI: 10.1007/s40266-018-0550-6
PMCID: PMC5999138
PMID: 29737468 [Indexed for MEDLINE]
Belkina TV, Khojiev DS, Tillyashaykhov MN, Tigay ZN, Kudenov MU, Tebbens JD,
Vlcek J.
BACKGROUND: Early diagnosis and prompt effective therapy are crucial for the
prevention of tuberculosis (TB) transmission, particularly in regions with high
levels of multi-drug resistant TB. This study aimed to evaluate the extent of
delay in diagnosis and treatment of TB in Uzbekistan and identify associated risk
factors.
METHODS: A cross-sectional study was performed on hospital patients with newly
diagnosed TB. The time between the onset of respiratory symptoms and initiation
of anti-TB treatment was assessed and delays were divided into patient, health
system and total delays. Univariable and multivariable logistic regression
analysis was used to evaluate determinants of diagnostic and treatment delay.
RESULTS: Among 538 patients enrolled, the median delay from onset of symptoms
until treatment with anti-TB drugs was 50 days. Analysis of the factors affecting
health-seeking behaviour and timely treatment showed the presence of the patient
factor. Self-medication was the first health-seeking action for 231 (43%)
patients and proved to be a significant predictor of delay (p = 0.005), as well
as coughing (p = 0.009), loss of weight (p = 0.001), and visiting private and
primary healthcare facilities (p = 0.03 and p = 0.02, respectively).
CONCLUSION: TB diagnostic and treatment delay was mainly contributed to by
patient delay and should be reduced through increasing public awareness of TB
symptoms and improving public health-seeking behaviour for timely initiation of
anti-TB treatment. Efforts should be made to minimise irrational use of
antibiotics and support interventions to restrict over-the-counter availability
of antibiotics.
DOI: 10.1186/s12879-014-0624-y
PMCID: PMC4248454
PMID: 25421106 [Indexed for MEDLINE]
377. Pharmacy (Basel). 2018 Jul 2;6(3). pii: E59. doi: 10.3390/pharmacy6030059.
Author information:
(1)Natalie Gauld Ltd., P. O. Box 9349, Newmarket, Auckland 1149, New Zealand.
n.gauld@gmail.com.
(2)Independent Researcher, Wellington, New Zealand. traceyinwales@yahoo.com.
The aim of this paper was to explore pharmacists' views on reclassifications from
pharmacy-only to general sales and their experiences with the supply of these
medicines, in addition to pharmacists' views on the reclassification of the
shingles vaccine and sildenafil to be available through 'accredited' pharmacists.
New Zealand community pharmacists were surveyed in 2013 with a written
questionnaire of six Likert-style or open-ended questions sent to Pharmacy Guild
member pharmacies. The analysis involved descriptive statistics. Responses were
received from 246 pharmacies. Two thirds of pharmacists supported the
reclassification of the shingles vaccine and sildenafil, although 14% disagreed
with the sildenafil reclassification. Over 90% of pharmacists disagreed with the
reclassification of paracetamol and ibuprofen liquids, omeprazole, naproxen, and
oxymetazoline from pharmacy-only medicine to general sales. This opinion was
strongest for omeprazole. With liquid paracetamol and ibuprofen, pharmacists
described consumer confusion with dosing, and particularly potentially
doubling-up on liquid analgesics/antipyretics including using both prescription
and non-prescription variants. Many reported giving safety advice frequently.
Anti-inflammatories and omeprazole were also subject to potential double-dosing,
as well as requests by consumers with contraindications, precautions, and drug
interactions, and for inappropriate indications. Pharmacists described various
interventions, including some that were potentially life-saving. Pharmacy
availability of medicines provides the potential for intervention that would not
happen in a general sales environment.
DOI: 10.3390/pharmacy6030059
PMCID: PMC6165278
PMID: 30004399
Shaqiri A(1), Willemin J(2), Sierro G(2), Roinishvili M(3), Iannantuoni L(2),
Rürup L(4), Chkonia E(3)(5), Herzog MH(1), Mohr C(2).
Author information:
(1)Laboratory of Psychophysics, Brain Mind Institute, Ecole Polytechnique
Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
(2)Institute of Psychology, Faculty of Social and Political Sciences, Bâtiment
Geopolis, Quartier Mouline, 1015 Lausanne, Switzerland.
(3)Institute of Cognitive Neurosciences, Agricultural University of Georgia,
Tbilisi, Georgia.
(4)Institute for Psychology and Cognition Research, University Bremen, Bremen,
Germany.
(5)Department of Psychiatry, Tbilisi State Medical University, Tbilisi, Georgia.
DOI: 10.1016/j.scog.2015.04.006
PMCID: PMC5609643
PMID: 29114459
Author information:
(1)Faculté de Médecine, Equipe de Pharmacoépidémiologie UMR 1027
INSERM-Université de Toulouse III, Service de Pharmacologie Médicale et Clinique,
Centre Hospitalier Universitaire de Toulouse, 37 allées Jules Guesde, 31000,
Toulouse, France. celine.caillet@univ-tlse3.fr.
(2)WorldWide Antimalarial Resistance Network, University of Oxford, Wellington
Square, OX1 2JD, Oxford, UK. singsing_chanvilay@yahoo.fr.
(3)Food and Drug Department, Ministry of Health, Simuang Road, Vientiane Capital,
Lao People's Democratic Republic. syhakhangl@yahoo.com.
(4)Faculté de Médecine, Cancer et maladies chroniques, UMR1027 INSERM- Université
de Toulouse III, 37 Allées Jules Gusede, 31000, Toulouse, France.
cyrildelpierre@yahoo.fr.
(5)Faculty of Pharmacy, University of Health Sciences, P.O.Box 7444, Samsenthai
Road, Vientiane, Lao People's Democratic Republic. manithipchanthanom@gmail.com.
(6)Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology
Laboratory, Mahosot Hospital, FaNgum Rd, Vientiane, Lao People's Democratic
Republic. mayfong@tropmedres.ac.
(7)Faculty of Postgraduate Studies, University of Health Sciences, P.O.Box 7444,
Samsenthai Road, Vientiane, Lao People's Democratic Republic.
mayfong@tropmedres.ac.
(8)Faculté de Médecine, Equipe de Pharmacoépidémiologie UMR 1027
INSERM-Université de Toulouse III, Service de Pharmacologie Médicale et Clinique,
Centre Hospitalier Universitaire de Toulouse, 37 allées Jules Guesde, 31000,
Toulouse, France. maryse.lapeyre-mestre@univ-tlse3.fr.
(9)WorldWide Antimalarial Resistance Network, University of Oxford, Wellington
Square, OX1 2JD, Oxford, UK. paul@tropmedres.ac.
(10)Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology
Laboratory, Mahosot Hospital, FaNgum Rd, Vientiane, Lao People's Democratic
Republic. paul@tropmedres.ac.
(11)Centre for Tropical Medicine and Global Health, Nuffield Department of
Medicine, Churchill Hospital, University of Oxford, Wellington Square, OX1 2JD,
Oxford, UK. paul@tropmedres.ac.
(12)Faculté de Médecine, Equipe de Pharmacoépidémiologie UMR 1027
INSERM-Université de Toulouse III, Service de Pharmacologie Médicale et Clinique,
Centre Hospitalier Universitaire de Toulouse, 37 allées Jules Guesde, 31000,
Toulouse, France. anne.roussin@univ-tlse3.fr.
BACKGROUND: While essential medicines have been made more available in all but
the most remote areas in low and middle income countries (L/MICs) over the past
years, inappropriate and incorrect use of good quality medicines remains a key
impediment for public health. In addition, as medicines have a potential to cause
harm (medicine risks), adequate awareness by medicine users of the risks of
adverse reactions is essential, especially as self-medication is common in
L/MICs. This study aimed to investigate the awareness of Lao residents regarding
medicine risks in Vientiane Capital, Lao People's Democratic Republic.
METHODS: Face-to-face interviews using structured questionnaires of 144 residents
older than 16 years were carried out in 12 randomly selected villages out of the
146 villages of Vientiane Capital with at least one health facility.
RESULTS: The respondents were mainly (85.0 %) the heads of households or their
husband/spouse . The majority of the respondents were unaware (61.8 %) of
medicine risks. Compared to residents living in the urban district of Xaysetha,
living in peri-urban and even more in rural areas were identified as factors
associated with being unaware of medicine risks [adjusted odds ratio (aOR) =3.3,
95 % Confidence Interval (CI) = 1.1-9.4]) and aOR =7.5 (95 % CI = 2.3-24.2),
respectively]. In addition, more than half of the respondents had never heard of
poor quality medicines, with a higher rate in rural/peri-urban compared to urban
districts (55.6 % vs 38.9 %, respectively, p = 0.02). Finally, approximately one
third of all respondents thought that traditional medicines could not cause harm.
CONCLUSIONS: Overall, these results suggest a lack of awareness about medicinal
product risks. Differences according to the place of residence are apparent and
could be partly explained by a lower level of training of healthcare providers in
contact with the population in the rural districts in particular. Communication
on medicinal product risks to patients through well-trained healthcare providers
could probably make a valuable contribution towards the appropriate use of
medicines in L/MICs.
DOI: 10.1186/s12889-015-1948-2
PMCID: PMC4483223
PMID: 26116373 [Indexed for MEDLINE]
Author information:
(1)Classified specialist, MH Ahmedabad, Gujrat, (Dermatology, Venereology and
Leprosy), Command Hospital, Eastern Command, Kolkata, West Bengal, India.
(2)Senior Advisor, MH Ahmedabad, Gujrat, (Dermatology, Venereology and Leprosy),
Command Hospital, Eastern Command, Kolkata, West Bengal, India.
DOI: 10.4103/0019-5154.152529
PMCID: PMC4372917
PMID: 25814713
Al-Kubaisi KA(1), De Ste Croix M(2), Vinson D(3), Sharif SI(4), Abduelkarem
AR(5).
Author information:
(1)University of Gloucestershire. Cheltenham (United Kingdom). Khalid@glos.ac.uk.
(2)University of Gloucestershire. Cheltenham (United Kingdom).
mdestecroix@glos.ac.uk.
(3)St John's Campus, University of Worcester, Worcester (United Kingdom).
d.vinson@worc.ac.uk.
(4)Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy,
University of Sharjah. Sharjah (United Arab Emirates). sharifsi@sharjah.ac.ae.
(5)Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy,
University of Sharjah. Sharjah (United Arab Emirates). aabdelkarim@sharjah.ac.ae.
Erratum in
Pharm Pract (Granada). 2018 Jul-Sep;16(3):1326. Ellis, Liz [removed].
DOI: 10.18549/PharmPract.2018.02.1172
PMCID: PMC6041208
PMID: 30023027
Conflict of interest statement: The authors declare that they have no conflicts
of interest.
The management of methamphetamine use in sexual settings among men who have sex
with men in Malaysia.
Lim SH(1), Akbar M(2), Wickersham JA(3), Kamarulzaman A(2), Altice FL(4).
Author information:
(1)Department of Social and Preventive Medicine, Faculty of Medicine, University
of Malaya, Kuala Lumpur, Malaysia; Centre of Excellence for Research in AIDS
(CERiA), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Electronic address: sinhow.lim@ummc.edu.my.
(2)Centre of Excellence for Research in AIDS (CERiA), Faculty of Medicine,
University of Malaya, Kuala Lumpur, Malaysia.
(3)Centre of Excellence for Research in AIDS (CERiA), Faculty of Medicine,
University of Malaya, Kuala Lumpur, Malaysia; Yale School of Medicine, Department
of Internal Medicine, Section of Infectious Diseases, AIDS Program, New Haven,
CT, USA.
(4)Yale School of Medicine, Department of Internal Medicine, Section of
Infectious Diseases, AIDS Program, New Haven, CT, USA.
BACKGROUND: The intentional use of illicit drugs for sexual purposes (also known
as 'chemsex') is well known within the MSM communities in Malaysia although
research in this population is scarce primarily because both drug use and
homosexuality are illegal and stigmatised in Malaysia.
METHODS: From April to December 2014, interviews were conducted with twenty men
(age range 21-43) living in Greater Kuala Lumpur who had sexual intercourse with
other men in the past 6 months and who used illicit drugs at least monthly in the
past 3 months. Fourteen men were recruited via gay social networking smartphone
applications or websites while six were referred by the participants. Data were
analsed using thematic analytic approach.
FINDINGS: The average duration of illicit drug use was 6.4 years (range 1-21) and
all participants were using methamphetamine ("ice" or crystal meth) with
frequency of use ranged from daily to once a month. Participants came from
diverse ethnic, economic, and occupational backgrounds. Most participants used an
inhalation apparatus ("bong") to consume methamphetamine and injection was rare
in the sample. The primary motivation of methamphetamine use was to increase
sexual capacity, heighten sexual pleasure and enhance sexual exploration and
adventurism. Socializing with friends ("chilling"), and increased energy for work
were secondary motivations. Participants emphasized the need to control the use
of methamphetamine and some have established rules to control the amount and
duration of use and a minority of men have maintained condom use during anal sex
while under the influence of methamphetamine. Participants who professed to be in
control of their drug use characterized themselves as functional users regardless
of the health and social consequences from continuing use. Overall, participants
perceived themselves differently from the traditional opioid users and reported
limited access to sexual health and substance use treatment services.
CONCLUSION: There is a need to increase access to HIV prevention services such as
PrEP and PEP, professional support, and substance abuse treatment for drug-using
MSM. A more open and friendly environment towards drug-using MSM may help them
access and engage with the health services.
DOI: 10.1016/j.drugpo.2018.02.019
PMCID: PMC6336456
PMID: 29605540 [Indexed for MEDLINE]
Alosaimi FD(1), Alruwais FS, Alanazi FA, Alabidi GA, Aljomah NA, Alsalameh NS.
Author information:
(1)Department of Psychiatry, King Saud University Medical City, King Saud
University, Riyadh, Kingdom of Saudi Arabia. E-mail: dr.fahad.alosaimi@gmail.com.
DOI: 10.17712/nsj.2016.4.20160245
PMCID: PMC5224432
PMID: 27744463 [Indexed for MEDLINE]
Sexual risk behaviors and steroid use among sexual minority adolescent boys.
Author information:
(1)Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United
States; Department of Psychiatry, Harvard Medical School, Boston, MA, United
States; The Fenway Institute, Fenway Health, Boston, MA, United States.
Electronic address: aaron.blashill@sdsu.edu.
(2)Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United
States; Department of Psychiatry, Harvard Medical School, Boston, MA, United
States; The Fenway Institute, Fenway Health, Boston, MA, United States.
Electronic address: ssafren@mgh.harvard.edu.
(3)The Fenway Institute, Fenway Health, Boston, MA, United States. Electronic
address: jjampel@fenwayhealth.org.
DOI: 10.1016/j.drugalcdep.2015.06.025
PMCID: PMC4646078
PMID: 26144592 [Indexed for MEDLINE]
Author information:
(1)Necmettin Erbakan University Medical Faculty, Division of Immunology and
Allergic Disease, Konya, Turkey. Necmettin Erbakan University Medical Faculty,
Division of Immunology and Allergic Disease, Konya, Turkey.
DOI: 10.5455/medarh.2014.68.426-427
PMCID: PMC4314155
PMID: 25648063 [Indexed for MEDLINE]
Author information:
(1)Centre for Research on Health and Social Care Management (CERGAS) SDA Bocconi
School of Management, Milan, Italy.
(2)Department of Social and Political Sciences, Bocconi University, Milan, Italy.
(3)Federchimica Assosalute, Milan, Italy.
(4)Department of Pharmaceutical Sciences, Università del Piemonte Orientale,
Novara, Italy.
Erratum in
Front Pharmacol. 2019 Mar 05;10:129.
The paper analyses the potential economic impact of switching drugs from
prescription-only to over the counter status, using Italy as a case-study. The
study assumes a societal perspective, investigating the effects of switches (and
consequent delisting) on drugs spending, avoided visits by GPs (General
Practitioners) and avoided time spent by patients for these visits. It overcomes
the main pitfalls of previous studies, providing a rational for listing
switchable products and applying both a static (no impact of switch on prices and
volumes consumed) and a dynamic approach (impact on pricing policies and volumes
depending on price-elasticity). Different scenarios were assumed including
shorter/longer time spent for visits and inclusion/exclusion of the economic
value of time of retiree patients. Results show that switching policy provides
with societal savings ranging from 1 to 2.1 1 billion Euro. The economic impact
on patients is less straightforward and depends on the scenarios used. If a
longer time is spent on visits, the economic value of this time will compensate
the cost of the switch to patients due to delisting. Despite the net economic
benefit should be carefully interpreted, the results demonstrate how switching
can contribute to the sustainability of the health care system in the middle-long
run thanks to the more rational use of resources, combined with an increased
awareness and responsibility of the involved stakeholders.
DOI: 10.3389/fphar.2018.01069
PMCID: PMC6199397
PMID: 30386233
"Chemsex" and harm reduction need among gay men in South London.
Bourne A(1), Reid D(2), Hickson F(2), Torres-Rueda S(3), Steinberg P(4),
Weatherburn P(2).
Author information:
(1)Sigma Research, Department of Social & Environmental Health Research, London
School of Hygiene & Tropical Medicine, London, United Kingdom. Electronic
address: adam.bourne@lshtm.ac.uk.
(2)Sigma Research, Department of Social & Environmental Health Research, London
School of Hygiene & Tropical Medicine, London, United Kingdom.
(3)Department of Global Health and Development, London School of Hygiene &
Tropical Medicine, London, United Kingdom.
(4)Public Health, London Borough of Lambeth, London, United Kingdom.
BACKGROUND: Chemsex is a colloquial term used by gay men in some parts of the UK
to describe the use of psychoactive substances (typically mephedrone, GHB/GBL or
crystal methamphetamine) during sex. Use of these drugs by gay men in London
appears to have risen sharply from relatively low levels and, as yet, there is
little data to inform appropriate harm reduction services. This study sought to
understand the personal and social context of chemsex and the nature of harm
reduction need.
METHODS: In-depth interviews were conducted with 30 self-identifying gay men (age
range 21-53) who lived in three South London boroughs, and who had used either
crystal methamphetamine, mephedrone or GHB/GBL either immediately before or
during sex with another man during the previous 12 months. Data were subjected to
a thematic analysis.
RESULTS: While around half of participants had utilised a range of drugs over
many years, others had only recently been introduced to drugs, often by sexual
partners who wished to enhance the sexual session. As relatively new drugs on the
gay scene, understanding of appropriate dosing was lacking and a majority
described overdoses, particularly in relation to GHB/GBL. Negotiation of sex,
especially in group sex environments, was complicated by the effects of the drugs
and a small number of men reported concerns relating to sexual consent. While a
significant proportion of men had experienced a range of physical and mental
health harms, few had accessed professional support for fear of judgement or
concern about chemsex expertise.
CONCLUSION: Findings from this study indicate a substantial degree of harm in the
usage of relatively new psychoactive substances in highly sexual circumstances.
Generic drug services, typically designed to address the needs of opiate users,
may not be sufficiently resourced to address the specific and acute needs of gay
men engaging in chemsex.
DOI: 10.1016/j.drugpo.2015.07.013
PMID: 26298332 [Indexed for MEDLINE]
USE OF DRUGS IN CHILDREN AGED ZERO TO FIVE YEARS OLD IN TUBARÃO, SANTA CATARINA,
BRAZIL.
Maniero HK(1), Martins AA(1), Melo AC(2), Paz LPDS(1), Schraiber RB(3), Galato
D(1).
Author information:
(1)Universidade de Brasília, Brasília, DF, Brasil.
(2)Universidade Federal de São João Del-Rei, Divinópolis, MG, Brasil.
(3)Universidade do Sul de Santa Catarina, Tubarão, SC, Brasil.
OBJECTIVE: To analyze the context of drug use in children aged zero to five years
old.
METHODS: Cross-sectional study based on interviews conducted at home with
caregivers (parents, uncles or grandparents) of the children enrolled in ten
Family Health Strategy units across different geographical points of the city of
Tubarão, Santa Catarina, Brazil.
RESULTS: A total of 350 caregivers were interviewed, whose children's mean age
was 2.6 years. Of these, 56.9% had used at least one drug in the 15 days prior to
the interview, 31.1% had been exposed to self-medication and 35.7% had used at
least one medication obtained by current prescription. The use of medication was
associated with the age range up to 24 months, periodic consultation with
pediatricians and diagnosis of chronic and acute diseases. Among medicated
children, 19.1% inappropriately had been exposed to at least one medication
(considering dose, dose interval or period of treatment). Regarding medication
storage, 55.2% of interviewees stored them in unsafe places that could be
accessed by children and 32.0% in inappropriate places, with exposure to light,
heat or humidity. Moreover, 45.2% of the interviewees stored drugs out of their
packages, 38.9% without secondary packaging, and 1.6% of drugs had expired date.
CONCLUSIONS: Drug use is high among children in this age range, and actions aimed
at the safe and rational use of these substances in this population should be
encouraged.
Author information:
(1)a School of Public Health , Zhejiang University , Hangzhou , PR China.
DOI: 10.1080/16549716.2018.1496973
PMCID: PMC6104601
PMID: 30132407 [Indexed for MEDLINE]
Dr Junkie. The Doctor Addict in Bulgakov's Morphine: What are the Lessons for
Contemporary Medical Practice?
Tischler V(1).
Author information:
(1)Division of Psychiatry and Applied Psychology, Institute of Mental Health,
University of Nottingham, Triumph Road, Nottingham, NG7 2TU, UK.
victoria.tischler@nottingham.ac.uk.
DOI: 10.1007/s10912-013-9259-z
PMCID: PMC4642586
PMID: 24221860 [Indexed for MEDLINE]
Blumenthal H(1), Cloutier RM(1), Zamboanga BL(2), Bunaciu L(3), Knapp AA(4).
Author information:
(1)Department of Psychology, University of North Texas.
(2)Department of Psychology, Smith College.
(3)Houston OCD Program.
(4)Department of Psychological Science, University of Arkansas.
DOI: 10.1037/pha0000022
PMCID: PMC4578981
PMID: 26053320 [Indexed for MEDLINE]
Austic EA(1).
Author information:
(1)Injury Center, Department of Emergency Medicine, University of Michigan, 2800
Plymouth Road, Suite B10-G080, Ann Arbor, MI 48109-2800, United States.
Electronic address: emeier@umich.edu.
Erratum in
Drug Alcohol Depend. 2016 Feb 1;159:289. Meier, E A Austic Formerly E A
[corrected to Austic, E A].
Müller M(1), Vandeleur C(2), Rodgers S(1), Rössler W(3), Castelao E(2), Preisig
M(2), Ajdacic-Gross V(1).
Author information:
(1)Department of Psychiatry, Psychotherapy and Psychosomatics, Zurich University
Hospital of Psychiatry, Militärstrasse 8, 8021 Zurich, Switzerland.
(2)Department of Psychiatry, CHUV, Site de Cery, 1008 Prilly, Lausanne,
Switzerland.
(3)Department of Psychiatry, Psychotherapy and Psychosomatics, Zurich University
Hospital of Psychiatry, Militärstrasse 8, 8021 Zurich, Switzerland; Collegium
Helveticum, University of Zurich and Swiss Federal Institute of Technology,
Schmelzbergstrasse 25, 8092 Zurich, Switzerland; Institute of Psychiatry,
Laboratory of Neuroscience (LIM 27), University of Sao Paulo, Medical School,
05403-010 Sao Paulo, SP, Brazil.
This study examined the role of posttraumatic stress disorder (PTSD) symptoms of
re-experience, avoidance, and hyperarousal in the relationship between different
types of trauma and alcohol use disorders (AUD). We used data from 731
trauma-exposed individuals who participated in the first wave of the
PsyCoLaus-study. Trauma characteristics were assessed relatively to the
occurrence of lifetime PTSD symptoms and AUD. The results suggest that lifetime
and childhood sexual abuse as well as overall childhood trauma were directly
linked to AUD and PTSD symptoms, in particular to avoidance symptoms. From single
symptom clusters PTSD avoidance was found to specifically mediate the trauma-AUD
pathway. Both childhood and sexual trauma strongly contribute to the comorbidity
of PTSD and AUD and avoidance-type symptoms appear to play a central role in
maintaining this association. Hence, the alleviation of avoidance symptoms might
be an important target for therapeutic intervention among victims of sexual abuse
before specific addiction treatment is initiated.
DOI: 10.1016/j.chiabu.2015.03.006
PMID: 25828861 [Indexed for MEDLINE]
Awuah RB(1), Asante PY(2), Sakyi L(3), Biney AAE(1), Kushitor MK(1), Agyei F(2),
de-Graft Aikins A(4).
Author information:
(1)Regional Institute for Population Studies, University of Ghana, Accra, Ghana.
(2)Department of Psychology, University of Ghana, Accra, Ghana.
(3)Centre for Migration Studies, University of Ghana, Accra, Ghana.
(4)Regional Institute for Population Studies, University of Ghana, Accra, Ghana.
adaikins@ug.edu.gh.
BACKGROUND: In Ghana, about 3.5 million cases of malaria are recorded each year.
Urban poor residents particularly have a higher risk of malaria mainly due to
poor housing, low socio-economic status and poor sanitation. Alternative
treatment for malaria (mainly African traditional/herbal and/or self-medication)
is further compounding efforts to control the incidence of malaria in urban poor
communities. This study assesses factors associated with seeking alternative
treatment as the first response to malaria, relative to orthodox treatment in
three urban poor communities in Accra, Ghana.
METHODS: This cross-sectional study was conducted in three urban poor localities
in Accra, Ghana among individuals in their reproductive ages (15-59 years for men
and 15-49 years for women). The analytic sample for the study was 707. A
multinomial regression model was used to assess individual, interpersonal and
structural level factors associated with treatment-seeking for malaria.
RESULTS: Overall, 31% of the respondents sought orthodox treatment, 8% sought
traditional/herbal treatment and 61% self-medicated as the first response to
malaria. At the bivariate level, more males than females used traditional/herbal
treatment and self-medicated for malaria. The results of the regression analysis
showed that current health insurance status, perceived relative economic
standing, level of social support, and locality of residence were associated with
seeking alternative treatment for malaria relative to orthodox treatment.
CONCLUSIONS: The findings show that many urban poor residents in Accra
self-medicate as the first response to malaria. Additionally, individuals who
were not enrolled in a health insurance scheme, those who perceived they had a
low economic standing, those with a high level of social support, and locality of
residence were significantly associated with the use of alternative treatment for
malaria. Multi-level strategies should be employed to address the use of
alternative forms of treatment for malaria within the context of urban poverty.
DOI: 10.1186/s12936-018-2311-8
PMCID: PMC5902882
PMID: 29661191 [Indexed for MEDLINE]
Author information:
(1)Information Center, National Institute of Health and Nutrition, 1-23-1 Toyama,
Shinjuku-ku, Tokyo 162-8636, Japan. tyschiba@nih.go.jp.
(2)Information Center, National Institute of Health and Nutrition, 1-23-1 Toyama,
Shinjuku-ku, Tokyo 162-8636, Japan. satoyoko@nih.go.jp.
(3)Information Center, National Institute of Health and Nutrition, 1-23-1 Toyama,
Shinjuku-ku, Tokyo 162-8636, Japan. sachina-s@nih.go.jp.
(4)Information Center, National Institute of Health and Nutrition, 1-23-1 Toyama,
Shinjuku-ku, Tokyo 162-8636, Japan. umegaki@nih.go.jp.
We previously reported that some patients used dietary supplements with their
medication without consulting with physicians. Dietary supplements and medicines
may interact with each other when used concomitantly, resulting in health
problems. An Internet survey was conducted on 2109 people who concomitantly took
dietary supplements and medicines in order to address dietary supplement usage in
people who regularly take medicines in Japan. A total of 1508 patients (two
admitted patients and 1506 ambulatory patients) and 601 non-patients, who were
not consulting with physicians, participated in this study. Purpose for dietary
supplement use was different among ages. Dietary supplements were used to treat
diseases in 4.0% of non-patients and 11.9% of patients, while 10.8% of patients
used dietary supplements to treat the same diseases as their medication. However,
70.3% of patients did not declare dietary supplement use to their physicians or
pharmacists because they considered the concomitant use of dietary supplements
and medicines to be safe. A total of 8.4% of all subjects realized the potential
for adverse effects associated with dietary supplements. The incidence of adverse
events was higher in patients who used dietary supplements to treat their
disease. Communication between patients and physicians is important for avoiding
the adverse effects associated with the concomitant use of dietary supplements
and medicines.
DOI: 10.3390/nu7042947
PMCID: PMC4425182
PMID: 25894658 [Indexed for MEDLINE]
Mesquita AR(1), Souza WM(1), Boaventura TC(1), Barros IM(1), Antoniolli AR(1),
Silva WB(1), Lyra Júnior DP(1).
Author information:
(1)Department of Pharmacy, Federal University of Sergipe, São Cristovão, Sergipe,
Brazil.
DOI: 10.1371/journal.pone.0123141
PMCID: PMC4430170
PMID: 25969991 [Indexed for MEDLINE]
Males of a strongly polygynous species consume more poisonous food than females.
Bravo C(1), Bautista LM(1), García-París M(2), Blanco G(1), Alonso JC(1).
Author information:
(1)Department of Evolutionary Ecology, Museo Nacional de Ciencias Naturales,
CSIC, Madrid, Madrid, Spain.
(2)Department of Biodiversity and Evolutionary Biology, Museo Nacional de
Ciencias Naturales, CSIC, Madrid, Madrid, Spain.
DOI: 10.1371/journal.pone.0111057
PMCID: PMC4206510
PMID: 25337911 [Indexed for MEDLINE]
The drugs don't sell: DIY heart health and the over-the-counter statin
experience.
Author information:
(1)Department of Sociology, University of Sussex, Brighton BN1 9SN, UK.
Electronic address: c.will@sussex.ac.uk.
(2)Institute for Science and Society, University of Nottingham, Nottingham NG7
2RD, UK; School of Psychological Sciences, University of Manchester, Manchester
M13 9PL, UK. Electronic address: k.weiner@sheffield.ac.uk.
DOI: 10.1016/j.socscimed.2014.04.033
PMID: 24954520 [Indexed for MEDLINE]
Author information:
(1)Central Clinical School, Monash University, Melbourne, Victoria, Australia.
(2)Melbourne Sexual Health Centre, The Alfred Hospital, Melbourne, Victoria,
Australia.
(3)Department of General Practice, The University of Melbourne, Melbourne,
Victoria, Australia.
(4)Centre for Values, Ethics and the Law in Medicine, The University of Sydney,
Sydney, New South Wales, Australia.
(5)Melbourne School of Population and Global Health, The University of Melbourne,
Melbourne, Victoria, Australia.
BACKGROUND: Few data are available on how women manage recurring bacterial
vaginosis (BV) and their experiences of the clinical care of this condition. This
study aimed to explore women's recurrent BV management approaches and clinical
care experiences, with a view to informing and improving the clinical management
of BV.
METHODS: A descriptive, social constructionist approach was chosen as the
framework for the study. Thirty-five women of varying sexual orientation who had
experienced recurrent BV in the past 5 years took part in semi-structured
interviews.
RESULTS: The majority of women reported frustration and dissatisfaction with
current treatment regimens and low levels of satisfaction with the clinical
management of BV. Overall, women disliked taking antibiotics regularly, commonly
experienced adverse side effects from treatment and felt frustrated at having
symptoms recur quite quickly after treatment. Issues in clinical care included
inconsistency in advice, misdiagnosis and inappropriate diagnostic approaches and
insensitive or dismissive attitudes. Women were more inclined to report positive
clinical experiences with sexual health physicians than primary care providers.
Women's frustrations led most to try their own self-help remedies and lifestyle
modifications in an attempt to treat symptoms and prevent recurrences, including
well-known risk practices such as douching.
CONCLUSION: In the face of considerable uncertainty about the cause of BV, high
rates of recurrence, unacceptable treatment options and often insensitive and
inconsistent clinical management, women are trying their own self-help remedies
and lifestyle modifications to prevent recurrences, often with little effect.
Clinical management of BV could be improved through the use of standardised
diagnostic approaches, increased sensitivity and understanding of the impact of
BV, and the provision of evidence based advice about known BV related risk
factors.
DOI: 10.1371/journal.pone.0151794
PMCID: PMC4807032
PMID: 27010725 [Indexed for MEDLINE]
Author information:
(1)Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania.
(2)Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
DOI: 10.15288/jsad.2016.77.287
PMCID: PMC4803661 [Available on 2017-03-01]
PMID: 26997187 [Indexed for MEDLINE]
Author information:
(1)Department of Family Medicine and Primary Health Care, Sefako Makgatho Health
Sciences University, South Africa.
(2)Department of Psychology, University of Limpopo, South Africa.
(3)Elim Hospital, South Africa.
Conflict of interest statement: The authors declare that they have no financial
or personal relationships which may have inappropriately influenced them in
writing this article.
Author information:
(1)Public Health England (PHE), London, United Kingdom.
DOI: 10.2807/1560-7917.ES.2015.20.34.30002
PMID: 26530125 [Indexed for MEDLINE]
Author information:
(1)Department of Community Health, Usmanu Danfodiyo University, Sokoto, Nigeria.
(2)Department of Paediatrics, Usmanu Danfodiyo University, Sokoto, Nigeria.
DOI: 10.4103/njcp.njcp_69_18
PMID: 30417847 [Indexed for MEDLINE]
Chagas OF(1), Éckeli FD(2), Bigal ME(3), Silva MO(4), Speciali JG(2).
Author information:
(1)Universidade de Ribeirão Preto, Ribeirão Preto, SP, Brazil.
(2)Divisão de Neurologia, Faculdade de Medicina de Ribeirão Preto, Universidade
de São Paulo, Ribeirão Preto, SP, Brazil.
(3)Migraine & Headache Clinical Development.
(4)Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo,
Ribeirão Preto, SP, Brazil.
DOI: 10.1590/0004-282X20150072
PMID: 26200053 [Indexed for MEDLINE]
405. Pharm Pract (Granada). 2014 Oct;12(4):451. Epub 2014 Mar 15.
Author information:
(1)Master in Pharmaceutical Sciences. Pharmaceutical Care Specialist Pharmacy in
Pharmaceutical Alfeirao. Vila Nova de Milfontes ( Portugal ).
rakacoelho@hotmail.com.
(2)Higher Institute of Health Sciences Egas Moniz . Centre for Interdisciplinary
Research Egas Moniz (CiiEM). Almada ( Portugal ). alvesdacosta.f@gmail.com.
PMCID: PMC4282762
PMID: 25580167
Emotional Distress, Alcohol Use, and Bidirectional Partner Violence Among Lesbian
Women.
Lewis RJ(1), Padilla MA(2), Milletich RJ(2), Kelley ML(2), Winstead BA(3),
Lau-Barraco C(3), Mason TB(2).
Author information:
(1)Virginia Consortium Program in Clinical Psychology, Norfolk, VA, USA Old
Dominion University, Norfolk, VA, USA rlewis@odu.edu.
(2)Old Dominion University, Norfolk, VA, USA.
(3)Virginia Consortium Program in Clinical Psychology, Norfolk, VA, USA Old
Dominion University, Norfolk, VA, USA.
DOI: 10.1177/1077801215589375
PMCID: PMC4490938
PMID: 26062874 [Indexed for MEDLINE]
Drowning the pain: intimate partner violence and drinking to cope prospectively
predict problem drinking.
Øverup CS(1), DiBello AM(2), Brunson JA(3), Acitelli LK(2), Neighbors C(2).
Author information:
(1)University of Houston, United States. Electronic address: coverup@uh.edu.
(2)University of Houston, United States.
(3)Pennsylvania State University, United States.
DOI: 10.1016/j.addbeh.2014.10.006
PMCID: PMC4948194
PMID: 25452060 [Indexed for MEDLINE]
Author information:
(1)Advanced Eye Centre, Post Graduate Institute of Medical Education and
Research, Chandigarh, India.
(2)Department of Internal Medicine, St. Vincent Hospital, Worcester, 123 Summer
Street-01608, USA.
DOI: 10.4103/ijo.IJO_365_18
PMCID: PMC6173047
PMID: 30249844 [Indexed for MEDLINE]
Flagel SB(1), Chaudhury S(2), Waselus M(2), Kelly R(3), Sewani S(3), Clinton
SM(4), Thompson RC(5), Watson SJ Jr(5), Akil H(1).
Author information:
(1)Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann
Arbor, MI 48109; Department of Psychiatry, University of Michigan, Ann Arbor, MI
48109; sflagel@umich.edu akil@umich.edu.
(2)Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann
Arbor, MI 48109;
(3)Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109;
(4)Department of Psychiatry, University of Alabama at Birmingham, Birmingham, AL
35233.
(5)Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann
Arbor, MI 48109; Department of Psychiatry, University of Michigan, Ann Arbor, MI
48109;
DOI: 10.1073/pnas.1520491113
PMCID: PMC4878471
PMID: 27114539 [Indexed for MEDLINE]
Preferences and attitudes of older adults of Bialystok, Poland toward the use of
over-the-counter drugs.
Author information:
(1)Department of Integrated Medical Care, Faculty of Health Sciences, Medical
University of Bialystok, Bialystok, Poland.
(2)National Security Student, Faculty of Social Sciences, University of Warmia
and Mazury in Olsztyn, Olsztyn, Poland.
(3)Department of Statistics and Medical Informatics, Faculty of Health Sciences,
Medical University of Bialystok, Bialystok, Poland.
Purpose: The aim of the study was to assess preferences and attitudes toward the
use of over-the-counter (OTC) drugs among residents of Bialystok aged 60 or
older.
Patients and methods: The study included 170 people, inhabitants of Bialystok
aged over 60: 85 students of the University of a Healthy Senior and the
University of Psychogeriatric Prophylaxis, and 85 students of the University of
the Third Age in Bialystok. The study made use of a diagnostic survey conducted
via a questionnaire prepared by the authors.
Results: The vast majority of respondents bought OTC drugs for own use. About
one-third of the respondents from each analyzed group bought OTC drugs less often
than once every 3 months. Over half of the respondents bought OTC drugs due to a
cold. A majority of the respondents were of the opinion that OTC drugs should be
sold only in pharmacies. Over 40% of seniors took 1 OTC drug regularly. Most
respondents also took vitamins and supplements. The main sources of information
on OTC drugs for the studied seniors were their doctor and pharmacist.
Respondents did not always consult the treatment method with a doctor or
pharmacist. Over half of the respondents familiarized themselves with the
contents of the OTC drug package leaflet. Over three-quarters of the respondents
were familiar with drug disposal methods; however, despite declarations of being
familiar with these principles, a significant percentage did not bring back
medication to a pharmacy or clinic, or threw the drugs into the trash.
Conclusion: Our study found that in our sample there were many OTC drug consumers
who did not always demonstrate responsible attitudes toward using this group of
drugs. Thus, older people should be educated on the possible adverse effects of
taking OTC drugs without consulting a doctor or pharmacist as well as basic drug
disposal principles. Furthermore, legislation should be introduced that will
limit the wide availability of OTC drugs, particularly to the elderly; and thus,
lower the costs of hospitalization and outpatient treatment of this age group.
Also, a wider-reaching study should be conducted. It should include a larger
group of elderly people as well as information on intake of prescribed
medications in order to be able to determine the frequency of drug consumption in
this population, as well as seniors' preferences and attitudes in this regard.
DOI: 10.2147/CIA.S158501
PMCID: PMC5901153
PMID: 29692605 [Indexed for MEDLINE]
Author information:
(1)School of Health Policy and Management, Nanjing Medical University, Nanjing,
China.
(2)Creative Health Policy Research Group, Nanjing Medical University, Nanjing,
China.
(3)School of Health Policy and Management, Nanjing Medical University, Nanjing,
China wzh04@njmu.edu.cn.
Assessment of the association between drug disposal practices and drug use and
storage behaviors.
Author information:
(1)Department of Medical Pharmacology, Marmara University Faculty of Medicine,
Istanbul, Turkey.
(2)Turkcell Global Bilgi Inc., Istanbul, Turkey.
DOI: 10.1016/j.jsps.2017.11.006
PMCID: PMC5783817
PMID: 29379327
413. Subst Abuse Treat Prev Policy. 2018 Oct 22;13(1):37. doi:
10.1186/s13011-018-0174-1.
Bagusat C(1), Kunzler A(2)(3), Schlecht J(2), Franke AG(4), Chmitorz A(2)(3),
Lieb K(2)(3).
Author information:
(1)Department of Psychiatry and Psychotherapy, University Medical Center Mainz,
Untere Zahlbacher Str. 8, 55131, Mainz, Germany. bagusat@uni-mainz.de.
(2)Department of Psychiatry and Psychotherapy, University Medical Center Mainz,
Untere Zahlbacher Str. 8, 55131, Mainz, Germany.
(3)German Resilience Center (DRZ) gGmbH, Untere Zahlbacher Str. 8, 55131, Mainz,
Germany.
(4)University of Applied Labour Studies, Bundesagentur für Arbeit, Seckenheimer
Landstr. 16, D-68163, Mannheim, Germany.
DOI: 10.1186/s13011-018-0174-1
PMCID: PMC6198480
PMID: 30348181 [Indexed for MEDLINE]
Perrin G(1)(2), Berdot S(1)(2)(3), Thomas F(4), Pannier B(4)(5), Danchin N(4)(6),
Durieux P(2)(7), Sabatier B(1)(2).
Author information:
(1)Department of Pharmacy, Georges-Pompidou European Hospital, Paris, France.
(2)INSERM UMR 1138 Team 22: Information Sciences to Support Personalized
Medicine, Cordelier Research Center, Paris, France.
(3)Department of Clinical Pharmacy, EA4123, Paris-Sud University,
Châtenay-Malabry, France.
(4)Centre d'Investigations Préventives et Cliniques, Paris, France.
(5)Department of Cardiology, Manhès Hospital, Fleury-Merogis, France.
(6)Department of Cardiology, Georges Pompidou European Hospital, Paris, France.
(7)Department of Biomedical Informatics and Public Health, Georges-Pompidou
European Hospital, Paris, France.
OBJECTIVES: The relationship between high dietary sodium intake and hypertension
is well established. Some drugs are associated with high-sodium content,
particularly effervescent tablets (ETs). Despite a possible cardiovascular risk
associated with the use of such drugs, observational data describing exposure to
ETs in ambulatory subjects are lacking.This study aims to estimate the prevalence
of exposure to ETs and to highlight factors associated with this exposure in a
large French health check-up population.
DESIGN: This was a cross-sectional study.
SETTING AND PARTICIPANTS: Participants were French individuals who underwent
medical check-ups at the Investigations Préventives et Cliniques centre between
April and June 2017.
RESULTS: In total, 1043 subjects were included in the study. The prevalence of
exposure to ETs in the last 30 days was 26.9% (95% CI 24.2% to 29.6%). Exposure
was frequent (ie, two ETs per week or more in the last 30 days) for 7.3% of
subjects. Self-medication was the major source of exposure (93.8%). Paracetamol,
aspirin, vitamins and betaine accounted for 95.3% of the ETs used. The factors
associated with this exposure by multivariate analysis were: male gender,
Overseas French origin, depression and body mass index ≥25 kg/m2. A diagnosis of
hypertension or treatment with diuretics were not protective factors against
exposure to ETs.
CONCLUSION: Exposure to ETs is frequent in the general population, particularly
through self-medication. Clinical conditions associated with low-salt
requirements were not associated with lower exposure to ETs, suggesting a lack of
awareness by practitioners and patients about this iatrogenic issue.
DOI: 10.1136/bmjopen-2018-022368
PMCID: PMC6067332
PMID: 30061444
Author information:
(1)Centre for Clinical Pharmacology, University Clinical Hospital Mostar, Mostar,
Bosnia and Herzegovina.
(2)Laboratory for Pain Research, University of Split School of Medicine, Split,
Croatia.
DOI: 10.2147/JPR.S118945
PMCID: PMC5138048
PMID: 27942233
Author information:
(1)Treatment Section, Clinical Pharmacology & Therapeutics Branch, Intramural
Research Branch of the National Institute on Drug Abuse, Baltimore, Maryland.
Author information:
(1)Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of
Jordan, Amman 11942 Jordan.
(2)Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The
University of Jordan, Amman 11942, Jordan.
Misconception about antibiotics use among the public has been widely outlined to
be a main reason for inappropriate use of antibiotics including failure to
complete treatment, skipping of doses, re-use of leftover medicines and overuse
of antibiotics. The study was devised to evaluate whether education might be a
potential strategy to promote safer use of antibiotics and reducing
self-medication. Two hundred seventy one adults were asked to complete two
questionnaires; a pre and posteducation. The questionnaires comprised of three
parts consisting of 17 statements assessing the knowledge on: appropriate use,
safe use and resistance of antibiotics. Knowledge score was estimated by
calculating the percentage of correct responses. The mean (SD) knowledge score
pre-education was 59.4% (20.3). However, posteducation the score was 65.9%
(17.9), p < 0.001(t-test). Knowledge scores were classified as poor, adequate and
good. Posteducation, participants within poor and adequate knowledge categories
were significantly shifted to the good category describing better knowledge,
McNemar-χ2 = 28.7, df = 3, p < 0.001. It is concluded that using tailored
education material targeting antibiotic need and use with a major aim of
improving the public knowledge about antibiotics can be an effective and feasible
strategy. This pilot study could be considered as the starting point for a wider
scale public educational intervention study and national antibiotic campaign.
However, the improvement in participant's knowledge might not reflect an actual
change in antibiotics-seeking behaviour or future retention of knowledge. Future
research should seek to assess the impact of education on participant's
behaviour.
DOI: 10.1016/j.jsps.2015.03.025
PMCID: PMC5059833
PMID: 27752235
Dhingra L(1), Perlman DC(2), Masson C(3), Chen J(4), McKnight C(5), Jordan AE(5),
Wasser T(6), Portenoy RK(7), Cheatle MD(8).
Author information:
(1)MJHS Institute for Innovation in Palliative Care, 39 Broadway, 12th Floor, New
York, NY 10006, USA. Electronic address: LDhingra@mjhs.org.
(2)Baron Edmond de Rothschild Chemical Dependency Institute, Mount Sinai Beth
Israel, First Avenue at 16th Street, New York, NY 10003, USA; Department of
Medicine, Mount Sinai Beth Israel, First Avenue at 16th Street, New York, NY
10003, USA; Center for Drug Use and HIV Research, New York University, 726
Broadway, New York, NY 10003, USA.
(3)Department of Psychiatry, University of California at San Francisco, 1001
Potrero Avenue, San Francisco, CA 94110, USA.
(4)MJHS Institute for Innovation in Palliative Care, 39 Broadway, 12th Floor, New
York, NY 10006, USA.
(5)Baron Edmond de Rothschild Chemical Dependency Institute, Mount Sinai Beth
Israel, First Avenue at 16th Street, New York, NY 10003, USA; Center for Drug Use
and HIV Research, New York University, 726 Broadway, New York, NY 10003, USA.
(6)Consult-Stat: Complete Statistical Services, 5754 Loyola Street, Macungie, PA
18062, USA.
(7)MJHS Institute for Innovation in Palliative Care, 39 Broadway, 12th Floor, New
York, NY 10006, USA; Department of Neurology, Albert Einstein College of
Medicine, Bronx, NY 10461, USA.
(8)Center for Studies of Addiction, Perelman School of Medicine, University of
Pennsylvania, Philadelphia, PA 19104, USA; Reading Health System, West Reading,
PA 19611, USA.
BACKGROUND: Little is known about the experience of chronic pain and the
occurrence of illicit drug use behaviors in the population enrolled in methadone
maintenance treatment (MMT) programs.
METHODS: This is a secondary analysis of longitudinal data from two MMT samples
enrolled in a randomized controlled trial of hepatitis care coordination.
Patients completed pain, illicit drug use, and other questionnaires at baseline
and 3, 9, and 12 months later. Associations were sought over time between the
presence or absence of clinically significant pain (average daily pain ≥ 4 or
mean pain interference ≥ 4 during the past week) and current illicit drug use
(i.e., non-therapeutic opioid, cocaine or amphetamine use identified from
self-report or urine drug screening).
RESULTS: Of 404 patients providing complete data, within-patient variability in
pain and illicit drug use was high across the four assessment periods. While 263
denied pain at baseline, 118 (44.9%) later experienced clinically significant
pain during ≥ 1 follow-up assessments. Of 180 patients (44.6%) without evidence
of illicit drug use at baseline, only 109 (27.0%) had similar negative drug use
at all follow-up assessments. Across four assessment periods, there was no
significant association between pain group status and current illicit drug use.
CONCLUSIONS: This one-year longitudinal analysis did not identify a significant
association between pain and illicit drug use in MMT populations. This finding
conflicts with some earlier investigations and underscores the need for
additional studies to clarify the complex association between pain and substance
use disorders in patients in MMT program settings.
DOI: 10.1016/j.drugalcdep.2015.02.007
PMCID: PMC4391061
PMID: 25735466 [Indexed for MEDLINE]
Author information:
(1)Department of Psychology, University of Manitoba, 190 Dysart Rd., Winnipeg, MB
R3T 2N2, Canada.
(2)Department of Psychology, Concordia University, 7141 Sherbrooke St. West,
Montreal, QC H4B 1R6, Canada.
Depression and alcohol use disorders are highly comorbid. Typically, alcohol use
peaks in emerging adulthood (e.g., during university), and many people also
develop depression at this time. Self-medication theory predicts that depressed
emerging adults drink to reduce negative emotions. While research shows that
depression predicts alcohol use and related problems in undergraduates, far less
is known about the continuity of this association after university. Most emerging
adults "mature out" of heavy drinking; however, some do not and go on to develop
an alcohol use disorder. Depressed emerging adults may continue to drink heavily
to cope with the stressful (e.g., remaining unemployed) transition out of
university. Accordingly, using parallel process latent class growth modelling, we
aimed to distinguish high- from low-risk groups of individuals based on joint
patterns of depression and alcohol misuse following university graduation.
Participants (N = 123) completed self-reports at three-month intervals for the
year post-graduation. Results supported four classes: class 1: low stable
depression and low decreasing alcohol misuse (n = 52), class 2: moderate stable
depression and moderate stable alcohol misuse (n = 35), class 3: high stable
depression and low stable alcohol misuse (n = 29), and class 4: high stable
depression and high stable alcohol misuse (n = 8). Our findings show that the
co-development of depression and alcohol misuse after university is not uniform.
Most emerging adults in our sample continued to struggle with significant
depressive symptoms after university, though only two classes continued to drink
at moderate (class 2) and high (class 4) risk levels.
DOI: 10.1016/j.abrep.2018.06.002
PMCID: PMC6039538
PMID: 30003136
Ice parties among young men who have sex with men in Thailand: Pleasures, secrecy
and risks.
Author information:
(1)Department of Society and Health, Faculty of Social Sciences and Humanities,
Mahidol University, Nakorn Pathom, Thailand; Center for Health Policy Studies,
Faculty of Social Sciences and Humanities, Mahidol University, Nakorn Pathom,
Thailand. Electronic address: thomas.gua@mahidol.ac.th.
(2)Department of Society and Health, Faculty of Social Sciences and Humanities,
Mahidol University, Nakorn Pathom, Thailand; Center for Health Policy Studies,
Faculty of Social Sciences and Humanities, Mahidol University, Nakorn Pathom,
Thailand.
DOI: 10.1016/j.drugpo.2018.04.005
PMCID: PMC5970987
PMID: 29691128 [Indexed for MEDLINE]
Seubert LJ(1), Whitelaw K(2), Hattingh L(3), Watson MC(4), Clifford RM(5).
Author information:
(1)The University of Western Australia, Pharmacy M315, 35 Stirling Highway,
Crawley WA 6009, Australia. Electronic address: liza.seubert@uwa.edu.au.
(2)The University of Western Australia, Pharmacy M315, 35 Stirling Highway,
Crawley WA 6009, Australia. Electronic address: kerry.whitelaw@uwa.edu.au.
(3)Curtin University, School of Pharmacy, Health Sciences, Kent Street, Bentley
WA 6102, Australia. Electronic address: l.hattingh@griffith.edu.au.
(4)University of Bath, 5W 3.33, Department of Pharmacy and Pharmacology,
Claverton Down, Bath England BA2 7AY, UK. Electronic address:
m.c.watson@bath.ac.uk.
(5)The University of Western Australia, Pharmacy M315, 35 Stirling Highway,
Crawley WA 6009, Australia. Electronic address: rhonda.clifford@uwa.edu.au.
Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.sapharm.2017.12.001
PMID: 29258734 [Indexed for MEDLINE]
422. Pharmacy (Basel). 2018 Sep 6;6(3). pii: E98. doi: 10.3390/pharmacy6030098.
What Do Customers Demand from Drug Stores in Japan? Construct Validity and Factor
Structure of a Cross-Sectional Survey.
Minamida Y(1), Yoshida N(2), Nishimaki-Tomizu M(3), Hanada M(4), Kimura K(5),
Tsuboi H(6).
Author information:
(1)School of Pharmacy, Kanazawa University, Kanazawa 920-1192, Japan.
minamida.yuuki@stu.kanazawa-u.ac.jp.
(2)Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University,
Kanazawa 920-1192, Japan. naoko@p.kanazawa-u.ac.jp.
(3)School of Pharmacy, Kanazawa University, Kanazawa 920-1192, Japan.
dmpc14@p.kanazawa-u.ac.jp.
(4)School of Pharmacy, Kanazawa University, Kanazawa 920-1192, Japan.
dmpc12@p.kanazawa-u.ac.jp.
(5)Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University,
Kanazawa 920-1192, Japan. kimurak@p.kanazawa-u.ac.jp.
(6)Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University,
Kanazawa 920-1192, Japan. tsuboih@p.kanazawa-u.ac.jp.
DOI: 10.3390/pharmacy6030098
PMCID: PMC6164702
PMID: 30200579
Author information:
(1)Associate Professor, Department of Obstetrics and Gynalcology, Government
Medical College , Jammu- J&K, India .
(2)Postgraduate Student, Department of Pharmacology, Government Medical College ,
Jammu- J&K, India .
(3)Assistant Professor, Department of Pharmacology, Government Medical College ,
Jammu- J&K, India .
(4)Professor and Head, Department of Medicine, Government Medical College ,
Jammu- J&K, India .
DOI: 10.7860/JCDR/2015/15806.6729
PMCID: PMC4668446
PMID: 26676079
Author information:
(1)Department of Psychological Sciences, University of Liverpool, United Kingdom.
(2)University of Dortmund, Germany.
(3)Child Guidance Clinic, Superior Court of the District of Columbia, United
States.
Alcohol use among adolescents in the United Kingdom (UK) remains relatively high
compared to those in other European countries. The present study sought to
examine both the direct and indirect effect of loneliness on drinking behavior.
Participants were school children (mean age 13.5 years at Time 1) participating
in a Randomized Controlled Trial in the UK, who completed a battery of
questionnaires examining alcohol-use indicators, loneliness, self-efficacy and
sensation seeking at Time 1 and at +12 months. Loneliness at Time 1 had a
substantive, though largely indirect (i.e., via self-efficacy and sensation
seeking covariates), impact on alcohol-related harm at +12 months. Furthermore,
Loneliness interacted with gender in the prediction of context of alcohol use,
where being female and experiencing loneliness put an individual at a greater
risk of unsupervised drinking. Females experiencing loneliness were also 2.9
times as likely to have had a drink in the past 30 days, and around 2.5 times as
likely to have ever consumed a full drink, when compared to their male peers. The
current results indicate that loneliness is an important but complex factor in
adolescent drinking. There are important implications for the development of
interventions to prevent underage drinking, not least that it is not appropriate
to consider all underage drinkers as socially marginalised. However, for those
that are, the self-medication hypothesis is potentially relevant through
emotional self-efficacy.
DOI: 10.1016/j.abrep.2017.07.003
PMCID: PMC5800553
PMID: 29450238
Author information:
(1)University of Connecticut Health Center, Farmington, CT, USA.
(2)School of Nursing and Center for Health Information and Prevention, University
of Connecticut, Storrs, CT, USA.
(3)Department of Communication Sciences and Center for Health Information and
Prevention, University of Connecticut, Storrs, CT, USA.
DOI: 10.2147/PPA.S74602
PMCID: PMC4309786
PMID: 25653508
DIY HIV prevention: Formative qualitative research with men who have sex with men
who source PrEP outside of clinical trials.
Paparini S(1), Nutland W(2), Rhodes T(2), Nguyen VK(1), Anderson J(3).
Author information:
(1)Department of Anthropology and Sociology of Development, Graduate Institute of
International and Development Studies, Geneva, Switzerland.
(2)Department of Social and Environmental Health Research, Faculty of Public
Health Policy, London School of Hygiene and Tropical Medicine, London, United
Kingdom.
(3)Homerton University Hospital NHS Foundation Trust, London, United Kingdom.
DOI: 10.1371/journal.pone.0202830
PMCID: PMC6107262
PMID: 30138482 [Indexed for MEDLINE]
Antibiotic misuse among children with diarrhea in China: results from a national
survey.
Li R(1), Xiao F(1), Zheng X(1), Yang H(1), Wang L(1), Yin D(1), Yin T(1), Xin
Q(1), Chen B(1).
Author information:
(1)Children Health and Development Department, Capital Institute of Paediatrics ,
Beijing , China.
DOI: 10.7717/peerj.2668
PMCID: PMC5101618
PMID: 27833822
Conflict of interest statement: The authors declare that they have no competing
interests.
Loeb LM(1), Amorim RP(1), Mazzacoratti MDGN(2), Scorza FA(1), Peres MFP(3).
Author information:
(1)Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento
de Neurologia/Neurocirurgia, São Paulo SP, Brasil.
(2)Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento
de Bioquímica, São Paulo SP, Brasil.
(3)Hospital Israelita Albert Einstein, São Paulo SP, Brasil.
OBJECTIVE: The aim of this work was to evaluate patients with chronic migraine
treated with botulinum toxin A (BT-A) and compare this with low level laser
therapy (LLLT), referencing: pain days, pain intensity, intake of
drugs/self-medication, anxiety and sleep disorders.
METHODS: Patients were randomized into two groups: BT-A group (n = 18) and LLLT
group (n = 18). Each patient kept three pain diaries: one before (baseline) (30
days), one during treatment (30 days) and one after the post-treatment phase (30
days). Repeated ANOVA plus the Bonferroni post-test, Student's t test, and
factorial analysis were applied, and p < 0.05 was accepted as significant.
RESULTS: Our data showed that both treatments were able to reduce headache days,
acute medication intake and decrease the intensity of pain. Anxiety was reduced
in the BT-A group, while sleep disturbance was reduced in the LLLT group.
CONCLUSION: Our data showed that both treatments can be used to treat chronic
migraine, without notable differences between them.
DOI: 10.1590/0004-282X20180109
PMID: 30427505 [Indexed for MEDLINE]
Schierz IAM(1), Giuffrè M(2), Piro E(2), La Placa S(2), Corsello G(2).
Author information:
(1)Neonatal ICU, Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone,"
Department of Sciences for Health Promotion and Mother and Child Care "Giuseppe
D'Alessandro," University of Palermo, Palermo, Italy inschier@tin.it.
(2)Neonatal ICU, Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone,"
Department of Sciences for Health Promotion and Mother and Child Care "Giuseppe
D'Alessandro," University of Palermo, Palermo, Italy.
DOI: 10.1542/peds.2016-3850
PMID: 29343586 [Indexed for MEDLINE]
Author information:
(1)PhD of Health Education, Professor, Ageing Health Department, School of Public
Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
(2)PhD of Nursing, Assistant Professor, Nursing Department, School of Nursing &
Midwifery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
(3)PhD Student in Health Education and Health Promotion, International Campus,
Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
DOI: 10.19082/6310
PMCID: PMC5878024
PMID: 29629053
Author information:
(1)Department of Biomedical Sciences, College of Medicine, King Faisal
University, Al- Hofuf, Kingdom of Saudi Arabia.
(2)Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King
Faisal University, Al-Hofuf, Kingdom of Saudi Arabia.
(3)Department of Microbiology, Faculty of Science, University of Nigeria Nsukka.
Nigeria.
PMCID: PMC6040858
PMID: 30022898
432. BMJ Case Rep. 2015 Apr 29;2015. pii: bcr2014208945. doi: 10.1136/bcr-2014-
208945.
Author information:
(1)NHS Lothian, Edinburgh, UK.
(2)National Poisons Information Service Edinburgh, NHS Lothian, Edinburgh, UK.
DOI: 10.1136/bcr-2014-208945
PMCID: PMC4422925
PMID: 25926584 [Indexed for MEDLINE]
433. Subst Abuse. 2015 May 24;9:39-46. doi: 10.4137/SART.S22233. eCollection 2015.
Author information:
(1)Substance Abuse and Mental Health Services Administration, Rockville, MD, USA.
(2)Research Triangle Institute, Chapel Hill, NC, USA.
(3)Health Resources and Services Administration, Rockville, MD, USA.
Case reports in medical literature suggest that the atypical antipsychotic
quetiapine, a medication not previously considered to have abuse potential, is
now being subject to misuse and abuse (MUA; ie, taken when not prescribed for
them or used in a way other than instructed by their health professional). Here
we present systematic, nationally representative data from the 2005 to 2011 Drug
Abuse Warning Network (DAWN) for prevalence of emergency department (ED) visits
among the U.S. general population involving quetiapine and related to MUA,
suicide attempts, and adverse reactions. Nationally, quetiapine-related ED visits
increased 90% between 2005 and 2011, from 35,581 ED visits to 67,497. DAWN data
indicate that when used without medical supervision for
recreational/self-medication purposes, quetiapine poses health risks for its
users, especially among polydrug users and women. These findings suggest that the
medical and public health communities should increase vigilance concerning this
drug and its potential for MUA.
DOI: 10.4137/SART.S22233
PMCID: PMC4444129
PMID: 26056465
Low EL(1), Whitaker KL(2), Simon AE(3), Sekhon M(3), Waller J(1).
Author information:
(1)Department of Epidemiology and Public Health, Health Behaviour Research
Centre, University College London (UCL), London, UK.
(2)School of Health Sciences, University of Surrey, Guildford, Surrey, UK.
(3)Centre for Health Services Research, City University, London, UK.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://group.bmj.com/group/rights-licensing/permissions.
DOI: 10.1136/bmjopen-2015-008082
PMCID: PMC4499727
PMID: 26150145 [Indexed for MEDLINE]
The relationship between bipolar disorder and cannabis use in daily life: an
experience sampling study.
Tyler E(1), Jones S(1), Black N(2), Carter LA(3), Barrowclough C(2).
Author information:
(1)The Spectrum Centre for Mental Health Research, Division of Health Research
Lancaster University, Lancaster, Lancashire, United Kingdom.
(2)School of Psychological Sciences, University of Manchester, Manchester, United
Kingdom.
(3)Health Methodology Research Group, School of Community Based Medicine,
University of Manchester, Manchester, United Kingdom.
Erratum in
PLoS One. 2015;10(3):e0123953.
DOI: 10.1371/journal.pone.0118916
PMCID: PMC4349825
PMID: 25738578 [Indexed for MEDLINE]
436. J Subst Abuse Treat. 2015 Jun;53:33-8. doi: 10.1016/j.jsat.2014.12.005. Epub
2014
Dec 30.
The Relationship Between Drug Use, Drug-related Arrests, and Chronic Pain Among
Adults on Probation.
Author information:
(1)The University of Texas School of Public Health, Department of Epidemiology,
Human Genetics and Environmental Sciences, Dallas Regional Campus, 6011 Harry
Hines Boulevard, V8.112, Dallas, TX 75390, USA. Electronic address:
Jennifer.reingle@utsouthwestern.edu.
(2)University of North Texas Health Science Center, School of Public Health, 3500
Camp Bowie Blvd., EAD 709, Fort Worth, TX 76107, USA. Electronic address:
Scott.Walters@unthsc.edu.
(3)George Mason University, Department of Criminology, Law and Society and Center
for Advancing Correctional Excellence (ACE!), 4087 University Drive, Suite 4100,
MSN 6D3, Fairfax, VA 22030, USA. Electronic address: jlerch@gmu.edu.
(4)George Mason University, Department of Criminology, Law and Society and Center
for Advancing Correctional Excellence (ACE!), 4087 University Drive, Suite 4100,
MSN 6D3, Fairfax, VA 22030, USA. Electronic address: ftaxman@gmu.edu.
The intersection between chronic health conditions, drug use, and treatment
seeking behavior among adults in the criminal justice system has been largely
understudied. This study examined whether chronic pain was associated with opiate
use, other illicit drug use, and drug-related arrests in a sample of
substance-using probationers. We expected that probationers with chronic
pain-related diagnoses would report more opiate use and drug-related arrests.
This study used baseline data from 250 adults on probation in Baltimore, Maryland
and Dallas, Texas who were participating in a larger clinical trial. Eighteen
percent of probationers in this sample reported suffering from chronic pain. In
bivariate analyses, probationers with chronic pain reported more drug-related
arrests (t=-1.81; p<0.05) than those without chronic pain. Multivariate analyses
support the hypothesis that probationers who reported chronic pain were
marginally more likely to use opiates (OR=2.37; 95% CI .89-1.05) and non-opiate
illicit drugs (OR=3.11; 95% CI 1.03-9.39) compared to offenders without chronic
pain. In summary, these findings suggest that adults under probation supervision
who suffer from chronic pain may be involved in criminal activity (specifically,
drug-related criminal activity) in an effort to self-medicate their physical
health condition(s). Screening probationers for chronic pain in the probation
setting and referring these adults to pain management treatment may be an
important step in advancing public safety.
DOI: 10.1016/j.jsat.2014.12.005
PMCID: PMC4414689
PMID: 25595302 [Indexed for MEDLINE]
Chen H(1), Ung COL(1), Chi P(1), Wu J(2), Tang D(3), Hu H(1).
Author information:
(1)1 University of Macau, China.
(2)2 University of Electronic Science and Technology of China, Chengdu, China.
(3)3 Beijing Jiaotong University, China.
DOI: 10.1177/0046958018793292
PMCID: PMC6088464
PMID: 30095016 [Indexed for MEDLINE]
Bryan AE(1), Norris J(1), Abdallah DA(1), Stappenbeck CA(2), Morrison DM(3),
Davis KC(3), George WH(4), Danube CL(1), Zawacki T(5).
Author information:
(1)Alcohol and Drug Abuse Institute, University of Washington.
(2)Department of Psychiatry and Behavioral Sciences, University of Washington.
(3)School of Social Work, University of Washington.
(4)Department of Psychology, University of Washington.
(5)Department of Psychology, University of Texas at San Antonio.
DOI: 10.1037/a0039411
PMCID: PMC4873161
PMID: 27213101
Chiba T(1), Sato Y(2), Nakanishi T(3), Yokotani K(4), Suzuki S(5), Umegaki K(6).
Author information:
(1)Information Center, National Institute of Health and Nutrition, 1-23-1 Toyama,
Shinjuku-ku, Tokyo 162-8636, Japan. tyschiba@nih.go.jp.
(2)Information Center, National Institute of Health and Nutrition, 1-23-1 Toyama,
Shinjuku-ku, Tokyo 162-8636, Japan. satoyoko@nih.go.jp.
(3)Information Center, National Institute of Health and Nutrition, 1-23-1 Toyama,
Shinjuku-ku, Tokyo 162-8636, Japan. nakanisi@nih.go.jp.
(4)Information Center, National Institute of Health and Nutrition, 1-23-1 Toyama,
Shinjuku-ku, Tokyo 162-8636, Japan. yokotani-k@swu.ac.jp.
(5)Information Center, National Institute of Health and Nutrition, 1-23-1 Toyama,
Shinjuku-ku, Tokyo 162-8636, Japan. sachina-s@nih.go.jp.
(6)Information Center, National Institute of Health and Nutrition, 1-23-1 Toyama,
Shinjuku-ku, Tokyo 162-8636, Japan. umegaki@nih.go.jp.
Recently, people have used dietary supplements not only for nutritional
supplementation, but also for treatment of their diseases. However, use of
dietary supplements to treat diseases, especially with medications, may cause
health problems in patients. In this study, we investigated use of dietary
supplements in patients in Japan. This survey was conducted from January to
December 2012, and was completed by 2732 people, including 599 admitted patients,
1154 ambulatory patients, and 979 healthy subjects who attended a seminar about
dietary supplements. At the time of the questionnaire, 20.4% of admitted
patients, 39.1% of ambulatory patients, and 30.7% of healthy subjects were using
dietary supplements, which including vitamin/mineral supplements, herbal
extracts, its ingredients, or food for specified health uses. The primary purpose
for use in all groups was health maintenance, whereas 3.7% of healthy subjects,
10.0% of ambulatory patients, and 13.2% of admitted patients used dietary
supplements to treat diseases. In addition, 17.7% of admitted patients and 36.8%
of ambulatory patients were using dietary supplements concomitantly with their
medications. However, among both admitted patients and ambulatory patients,
almost 70% did not mention dietary supplement use to their physicians. Overall,
3.3% of all subjects realized adverse effects associated with dietary
supplements. Communication between patients and physicians is important to avoid
health problems associated with the use of dietary supplements.
DOI: 10.3390/nu6125392
PMCID: PMC4276974
PMID: 25431879 [Indexed for MEDLINE]
Author information:
(1)Department of Microbiology, University of Nigeria, Nsukka.
DOI: 10.4314/ahs.v17i4.27
PMCID: PMC5870271
PMID: 29937890 [Indexed for MEDLINE]
Author information:
(1)From the Institute of Psychiatry (CC, MC), the Federal University of Rio de
Janeiro, RJ, Brazil; and Clementino Fraga Filho Hospital (AA, MB), Federal
University of Rio de Janeiro, RJ, Brazil.
OBJECTIVE: Alert for the risk of oral bupropion addiction in patients with
cocaine dependence.
METHODS: Single-case study.
RESULTS: After a period of cocaine and alcohol abstinence, a 42-year-old patient
started taking oral bupropion to relieve the symptoms of cocaine craving. He
increased the bupropion dose up to 2250 mg/d without seizures.
CONCLUSION: This case highlights the possibility of oral bupropion addiction
after cocaine dependence. To our knowledge, it is the first case in the
literature and emphasizes the risk of bupropion's misuse. Therefore, physicians
should carefully examine the patient's profile before prescribing it, as well as
follow appropriate measures.
DOI: 10.1097/ADM.0000000000000098
PMCID: PMC4374723
PMID: 25494008 [Indexed for MEDLINE]
442. Demogr Res. 2018;38. pii: 17. doi: 10.4054/DemRes.2018.38.17. Epub 2018 Jan
30.
Uninsured Migrants: Health Insurance Coverage and Access to Care Among Mexican
Return Migrants.
Wassink J(1).
Author information:
(1)University of North Carolina at Chapel Hill, Department of Sociology and
Carolina Population Center.
DOI: 10.4054/DemRes.2018.38.17
PMCID: PMC5894520
PMID: 29657545
Author information:
(1)Department of Panchakarma, National Institute of Ayurveda, Jaipur, India.
(2)Department of Panchakarma, S.S.S.B. Ayurvedic College and Hospital, Jaipur,
Rajasthan, India.
DOI: 10.4103/0974-8520.169015
PMCID: PMC4687243
PMID: 26730142
Author information:
(1)Clinical Psychology and Psychotherapy, Department of Psychology, Bielefeld
University, Bielefeld, Germany.
(2)vivo international, Konstanz, Germany.
Background and Aims: Since alcohol use disorders are among the most prevalent and
destructive mental disorders, it is critical to address factors contributing to
their development and maintenance. Drinking motives are relevant driving factors
for consumption. Identifying groups of drinkers with similar motivations may help
to specialize intervention components and make treatment more effective and
efficient. We aimed to identify and describe distinct motive types of drinkers in
dependent males from two diverse cultures (Uganda and Germany) and to explore
potential differences and similarities in addiction-related measures. Moreover,
we investigated specific links between motive types and childhood maltreatment,
traumatic experiences, and symptoms of comorbid psychopathologies.
Methods: To determine distinct drinking motive types, we conducted latent class
analyses concerning drinking motives (Drinking Motive Scale) in samples of
treatment-seeking alcohol-dependent men (N = 75). Subsequently we compared the
identified motive types concerning their alcohol consumption and alcohol-related
symptoms (Alcohol Use Disorders Identification Test), history of childhood
maltreatment (Childhood Trauma Questionnaire), trauma exposure (Violence, War and
Abduction Exposure Scale), psychopathology (Posttraumatic Stress Diagnostic
Scale, Depression-section of the Hopkins Symptom Checklist, and Brief Symptom
Inventory) and deficits in emotion regulation (Difficulties in Emotion Regulation
Scale).
Results: We found two congruent drinking motive types in both contexts.
Reward-oriented drinking motives like the generation of positive feelings and
enhancing performance were endorsed almost equally by both motive types, whereas
high relief motive endorsement characterized one group, but not the other. The
relief motive type drank to overcome aversive feelings, withdrawal, and daily
hassles and was characterized by higher adversity in general. Emotional
maltreatment in childhood and psychopathological symptoms were reported to a
significantly greater extent by relief drinkers (effect sizes of comparisons
ranging from r = 0.25 to r = 0.48). However, the motive types did not differ
significantly on alcohol consumption or alcohol-related symptoms and traumatic
experiences apart from childhood maltreatment.
Conclusion: The chronology of addiction development and patterns of drinking
motivation seem to be similar across cultures, i.e., that motive targeting
interventions might be applicable cross-culturally. Addressing comorbid
symptomatology should be a key treatment component for relief drinkers, whereas
finding alternatives for the creation of positive feelings and ways to counteract
boredom and inactivity should be a general treatment element.
DOI: 10.3389/fpsyt.2018.00038
PMCID: PMC5816937
PMID: 29487544
445. Ecol Evol. 2014 Oct;4(20):3960-7. doi: 10.1002/ece3.1252. Epub 2014 Sep 26.
Erler S(1), Denner A(1), Bobiş O(2), Forsgren E(3), Moritz RF(4).
Author information:
(1)Departamentul de Apicultură şi Sericicultură, Universitatea de Ştiinţe
Agricole şi Medicină Veterinară Calea Mănăştur 3-5, 400372, Cluj-Napoca, Romania
; Institut für Biologie, Molekulare Ökologie, Martin-Luther-Universität
Halle-Wittenberg Hoher Weg 4, 06099, Halle, Germany.
(2)Departamentul de Apicultură şi Sericicultură, Universitatea de Ştiinţe
Agricole şi Medicină Veterinară Calea Mănăştur 3-5, 400372, Cluj-Napoca, Romania.
(3)Department of Ecology, Swedish University of Agricultural Sciences P.O. Box
7044, 75007, Uppsala, Sweden.
(4)Departamentul de Apicultură şi Sericicultură, Universitatea de Ştiinţe
Agricole şi Medicină Veterinară Calea Mănăştur 3-5, 400372, Cluj-Napoca, Romania
; Institut für Biologie, Molekulare Ökologie, Martin-Luther-Universität
Halle-Wittenberg Hoher Weg 4, 06099, Halle, Germany ; Department of Zoology and
Entomology, University of Pretoria 0002, Pretoria, South Africa.
DOI: 10.1002/ece3.1252
PMCID: PMC4242578
PMID: 25505523
Cunningham EB(1), Jacka B(2), DeBeck K(3), Applegate TL(2), Harrigan PR(4),
Krajden M(5), Marshall BD(6), Montaner J(7), Lima VD(7), Olmstead AD(5), Milloy
MJ(7), Wood E(7), Grebely J(2).
Author information:
(1)Viral Hepatitis Clinical Research Program, The Kirby Institute, UNSW
Australia, Sydney, NSW, Australia. Electronic address:
ecunningham@kirby.unsw.edu.au.
(2)Viral Hepatitis Clinical Research Program, The Kirby Institute, UNSW
Australia, Sydney, NSW, Australia.
(3)British Columbia Centre for Excellence in HIV/AIDS, St Paul's Hospital,
Vancouver, BC, Canada; School of Public Policy, Simon Fraser University,
Vancouver, BC, Canada.
(4)British Columbia Centre for Excellence in HIV/AIDS, St Paul's Hospital,
Vancouver, BC, Canada.
(5)BC Centre for Disease Control, Vancouver, BC, Canada.
(6)Department of Epidemiology, Brown University School of Public Health,
Providence, RI, United States.
(7)British Columbia Centre for Excellence in HIV/AIDS, St Paul's Hospital,
Vancouver, BC, Canada; Division of AIDS, Department of Medicine, Faculty of
Medicine, University of British Columbia, Vancouver, BC, Canada.
DOI: 10.1016/j.drugalcdep.2015.04.005
PMCID: PMC4461061
PMID: 25977204 [Indexed for MEDLINE]
The prevalence of halitosis (oral malodor) and associated factors among dental
students and interns, Lahore, Pakistan.
Author information:
(1)Department of Preventive Dental Sciences, University of Dammam College of
Dentistry, Dammam, KSA.
(2)Department of Prosthetics, College of Dentistry, King Khalid University, Abha,
KSA.
DOI: 10.4103/ejd.ejd_142_17
PMCID: PMC5727733
PMID: 29279674
Conflict of interest statement: There are no conflicts of interest.
448. Ann Intensive Care. 2016 Dec;6(1):9. doi: 10.1186/s13613-016-0109-9. Epub 2016
Feb 2.
Jolivot PA(1)(2), Pichereau C(3), Hindlet P(1)(2)(4), Hejblum G(1), Bigé N(3),
Maury E(1)(3), Guidet B(1)(3), Fernandez C(5)(6)(7).
Author information:
(1)Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis
d'Epidémiologie et de Santé Publique (IPLESP UMRS 1136), Equipe 6, 75012, Paris,
France.
(2)APHP, Hôpital Saint-Antoine, Service de Pharmacie, 75012, Paris, France.
(3)APHP, Hôpital Saint-Antoine, Service de Réanimation Médicale, 75012, Paris,
France.
(4)Univ Paris-Sud, Faculté de Pharmacie, 92296, Châtenay-Malabry, France.
(5)Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis
d'Epidémiologie et de Santé Publique (IPLESP UMRS 1136), Equipe 6, 75012, Paris,
France. christine.fernandez@aphp.fr.
(6)APHP, Hôpital Saint-Antoine, Service de Pharmacie, 75012, Paris, France.
christine.fernandez@aphp.fr.
(7)Univ Paris-Sud, Faculté de Pharmacie, 92296, Châtenay-Malabry, France.
christine.fernandez@aphp.fr.
DOI: 10.1186/s13613-016-0109-9
PMCID: PMC4735088
PMID: 26830112
449. J Neurosci. 2015 Feb 4;35(5):1872-9. doi: 10.1523/JNEUROSCI.2777-14.2015.
Parvaz MA(1), Konova AB(2), Proudfit GH(3), Dunning JP(4), Malaker P(1), Moeller
SJ(1), Maloney T(1), Alia-Klein N(1), Goldstein RZ(5).
Author information:
(1)Department of Psychiatry and Neuroscience, Icahn School of Medicine at Mount
Sinai, New York, New York 10029.
(2)Center for Neural Science, New York University, New York, New York 10003.
(3)Department of Psychology, Stony Brook University, Stony Brook, New York 11970,
and.
(4)Department of Psychology, Nevada State College, Henderson, Nevada 89002.
(5)Department of Psychiatry and Neuroscience, Icahn School of Medicine at Mount
Sinai, New York, New York 10029, rita.goldstein@mssm.edu.
DOI: 10.1523/JNEUROSCI.2777-14.2015
PMCID: PMC4315825
PMID: 25653348 [Indexed for MEDLINE]
Cross-sex hormone use, functional health and mental well-being among transgender
men (Toms) and Transgender Women (Kathoeys) in Thailand.
There exists limited understanding of cross-sex hormone use and mental well-being
among transgender women and, particularly, among transgender men. Moreover, most
studies of transgender people have taken place in the Global North and often in
the context of HIV. This exploratory study compared 60 transgender men (toms)
with 60 transgender women (kathoeys) regarding their use of cross-sex hormones,
mental well-being and acceptance by their family. Participants also completed a
dispositional optimism scale (the Life Orientation Test Revised), the Social
Functioning Questionnaire and the Short Form Health Survey 36 assessing their
profile of functional health and mental well-being. Cross-sex hormones were used
by 35% of toms and 73% of kathoeys and were largely unsupervised by
health-related personnel. There were no differences in functional health and
mental well-being among toms and kathoeys. However, toms currently using
cross-sex hormones scored on average poorer on bodily pain and mental health,
compared to non-users. Furthermore, compared to non-users, cross-sex hormone
users were about eight times and five times more likely to be associated with
poor parental acceptance among toms and kathoeys, respectively. This study was
the first to compare cross-sex hormone use, functional health and mental
well-being among transgender women and transgender men in Southeast Asia.
DOI: 10.1080/13691058.2014.950982
PMCID: PMC4227918
PMID: 25270637 [Indexed for MEDLINE]
Author information:
(1)Gastroenterohepatology Research Center, Shiraz University of Medical Sciences,
Shiraz, IR Iran.
DOI: 10.5812/hepatmon.32654
PMCID: PMC4887962
PMID: 27257424
Author information:
(1)Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan.
dorji.thinleydr@gmail.com.
(2)Kidu Medical Unit, His Majesty's Peoples' Project, Thimphu, Bhutan.
dorji.thinleydr@gmail.com.
(3)Phuentsholing General Hospital, Phuentsholing, Bhutan.
(4)Holistic and Oriental Medicine Research Center, Faculty of Medicine,
Chulalongkorn University, Bangkok, Thailand.
(5)Department of International Health, Johns Hopkins Bloomberg School of Public
Health, Baltimore, MD, USA.
DOI: 10.1186/s13104-018-3764-0
PMCID: PMC6131944
PMID: 30201047 [Indexed for MEDLINE]
453. Exp Ther Med. 2019 Feb;17(2):1020-1023. doi: 10.3892/etm.2018.6983. Epub 2018
Nov
16.
Boca AN(1), Ilies RF(2), Saccomanno J(2), Pop R(1), Vesa S(1), Tataru AD(3),
Buzoianu AD(1).
Author information:
(1)Department of Pharmacology, Toxicology and Clinical Pharmacology, 'Iuliu
Hatieganu' University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
(2)Faculty of Medicine, 'Iuliu Hatieganu' University of Medicine and Pharmacy,
400012 Cluj-Napoca, Romania.
(3)Department of Dermatology, 'Iuliu Hatieganu' University of Medicine and
Pharmacy, 400000 Cluj-Napoca, Romania.
DOI: 10.3892/etm.2018.6983
PMCID: PMC6327666
PMID: 30679968
Use of Psychotropic Medications and Illegal Drugs, and Related Consequences Among
French Pharmacy Students - SCEP Study: A Nationwide Cross-Sectional Study.
Balayssac D(1), Pereira B(2), Darfeuille M(3), Cuq P(4), Vernhet L(5), Collin
A(6), Vennat B(7), Authier N(8).
Author information:
(1)Inserm U1107, NEURO-DOL, Faculté de Pharmacie, Laboratoire de Toxicologie,
Université Clermont Auvergne, CHU Clermont-Ferrand, Délégation à la Recherche
Clinique et à l'Innovation, Clermont-Ferrand, France.
(2)CHU Clermont-Ferrand, Délégation à la Recherche Clinique et à l'Innovation,
Clermont-Ferrand, France.
(3)Faculté de Pharmacie, Laboratoire de Toxicologie, Université Clermont
Auvergne, Clermont-Ferrand, France.
(4)Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, ENSCM, Faculté
de Pharmacie, Université de Montpellier, Montpellier, France.
(5)UMR Inserm 1085, Institut de Recherche sur la Santé, l'Environnement et le
Travail (IRSET), Université de Rennes 1, Rennes, France.
(6)Inserm U1107, NEURO-DOL, Faculté de Pharmacie, Laboratoire de Toxicologie,
Université Clermont Auvergne, Clermont-Ferrand, France.
(7)ACCePPT, Faculté de Pharmacie, Université Clermont Auvergne, Clermont-Ferrand,
France.
(8)Inserm U1107, NEURO-DOL, Université Clermont Auvergne, Faculté de Médecine,
CHU Clermont-Ferrand, Pharmacologie Médicale, Clermont-Ferrand, France.
DOI: 10.3389/fphar.2018.00725
PMCID: PMC6056660
PMID: 30065649
Musinguzi G(1)(2), Anthierens S(2), Nuwaha F(1), Van Geertruyden JP(3), Wanyenze
RK(1), Bastiaens H(2).
Author information:
(1)Department of Disease Control and Environmental Health, School of Public
Health, Makerere University, Kampala, Uganda.
(2)Primary and Interdisciplinary Care, University of Antwerp, Antwerp, Belgium.
(3)International Health, University of Antwerp, Antwerp, Belgium.
DOI: 10.1155/2018/8307591
PMCID: PMC5944291
PMID: 29854433
Author information:
(1)Department of Diagnostic Radiology, Changi General Hospital, Singapore.
Joe_Francis@cgh.com.sg; joefrancis01@gmail.com.
(2)Department of Diagnostic Radiology, Changi General Hospital, Tan Tock Seng
Hospital, Singapore.
(3)Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore.
Penile paraffinoma is a rare but well-known entity. There have been few studies
describing the ultrasound and MRI features of penile paraffinoma. In this case
series we describe the imaging findings of 4 patients who self-injected "Jamaica
oil" into their penises for the purpose of penile augmentation and discuss the
utility of US and MRI in the management of these patients.
Motivations for Prescription Drug Misuse among Young Adults: Considering Social
and Developmental Contexts.
LeClair A(1), Kelly BC(2), Pawson M(3), Wells BE(4), Parsons JT(5).
Author information:
(1)Institute for Health, Health Care Policy & Aging Research, Rutgers University.
(2)Purdue University ; Center for HIV Educational Studies & Training, CUNY.
(3)Center for HIV Educational Studies & Training, CUNY ; Graduate Center, CUNY.
(4)Center for HIV Educational Studies & Training, CUNY ; Hunter College, CUNY.
(5)Center for HIV Educational Studies & Training, CUNY ; Hunter College, CUNY ;
Graduate Center, CUNY.
AIMS: As part of a larger study on prescription drug misuse among young adults
active in urban nightlife scenes, we examined participants' motivations for
misuse. Prescription painkillers, stimulants and sedatives were the primary
substances of interest.
METHODS: Participants were recruited from nightlife venues in New York using
time-space sampling. Subjects completed a mixed-methods assessment at project
research offices. The data presented here are from a subsample of 70 qualitative
interviews conducted during the baseline assessment.
FINDINGS: We identified experimentation and a "work hard, play hard" ethos as key
motivations for misusing prescription drugs and argue that these motivations are
specific, though not necessarily unique, to the participants' social location as
young adults. These findings highlight the role of life stage and social context
in the misuse of prescription drugs.
CONCLUSION: Future studies of prescription drug misuse should pay attention to
the larger social contexts in which users are embedded and, therefore, make
decisions about how and why to misuse. Moving beyond the very broad concepts of
"recreation" and "self-medication" presently established in the research,
policies targeting young adults may want to tailor intervention efforts based on
motivations.
DOI: 10.3109/09687637.2015.1030355
PMCID: PMC4689195
PMID: 26709337
Author information:
(1)Outpatient Department, Karmøy District Psychiatric Center, Kopervik, Norway.
(2)Faculty of Psychology, Department of Clinical Psychology, University of
Bergen, Bergen, Norway.
(3)The Stine Sofies Foundation and The Stine Sofie Centre, Grimstad, Norway.
Author information:
(1)University of Camerino. stefania.scuri@unicam.it.
BACKGROUND AND AIM: In recent years, self-medication is an increasing public
health issue, also among the European young people. Only 48% of people throughout
the world use prescribed medications, while the remainder admits that they
self-medicate with over the counter drugs or leftover prescribed drugs. Also, the
risk of antibiotic resistance, throughout the world, has doubled, due to the
recourse to these drugs when they are not called for, or to failure to follow
their instructions for use.
METHODS: A five-part questionnaire, translated into the national languages and
validated, was given to Pharmacy students in Italy, Spain, the Czech Republic and
Romania obtain anonymous information about their pharmaceutical drugs use.
RESULTS: Regarding the use of pharmaceutical drugs, students in Spain and Romania
indicated the highest percentages of use. In Italy and Romania, the pharmacist is
rarely consulted, while the advice of family members or friends is more
frequently requested. In all four countries the problem of taking antibiotics
without a medical prescription is significant, and 50% of Romanian students use
antibiotics to treat the flu. Another important result is that, in Spain, 38.4%
of the respondents admitted to using medicines with alcohol.
CONCLUSIONS: Considering that the drug information leaflet is not read by 50% of
young people interviewed, it would be important for public health entities to
instruct the population, especially younger age groups such as secondary school
students, about the importance of reading this information carefully. The use of
mass media in such a preventive medicine campaign could be effective.
DOI: 10.23750/abm.v90i1.7572
PMCID: PMC6502160
PMID: 30889159
Author information:
(1)Department of Clinical Pharmacy, College of Pharmacy and Dentistry, Buraidah
Private Colleges, Al Qassim, Saudi Arabia.
(2)Department of Pharmacology, College of Pharmacy and Dentistry, Buraidah
Private Colleges, Al Qassim, Saudi Arabia.
(3)Department of Pharmaceutical Chemistry, College of Pharmacy and Dentistry,
Buraidah Private Colleges, Al Qassim, Saudi Arabia.
DOI: 10.1016/j.jsps.2014.06.007
PMCID: PMC4421000
PMID: 25972732
461. Pain Manag. 2019 Jul 1;9(4):379-387. doi: 10.2217/pmt-2018-0092. Epub 2019 Apr
2.
Author information:
(1)Reckitt Benckiser Healthcare International Ltd, 103-105 Bath Road, Slough,
Berkshire, SL1 3UH, UK.
DOI: 10.2217/pmt-2018-0092
PMID: 30938229
462. BMC Health Serv Res. 2018 Dec 3;18(1):915. doi: 10.1186/s12913-018-3753-y.
"You could lose when you misuse" - factors affecting over-the-counter sale of
antibiotics in community pharmacies in Saudi Arabia: a qualitative study.
Author information:
(1)Department of Pharmacy Practice, College of Clinical Pharmacy, Imam
Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. f.k.alhomoud@gmail.com.
(2)Department of Pharmacy Practice, College of Clinical Pharmacy, Imam
Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
BACKGROUND: The sale of antibiotics without a prescription poses a global public
health concern. Antibiotics dispensed without a prescription are largely
recognised as a cause of antibiotic misuse and overuse which may result in
antibiotic resistance, recurrent infection, increased cost and adverse effects of
treatment. There have been no qualitative studies to explore the reasons for
over-the-counter (OTC) sale of antibiotics, despite the fact that
non-prescription sale of antibiotics are increasing in Saudi Arabia.
METHODS: Qualitative interviews were conducted with community pharmacists living
in the Eastern Province of Saudi Arabia using face-to-face, open-ended questions.
Interviews were audio-recorded and transcribed verbatim. The interview
transcripts were analysed using thematic analysis and NVivo 10 software.
RESULTS: All participants declared that antibiotics were frequently sold without
a medical prescription on an OTC basis. The main reasons for OTC sale of
antibiotics were found to be related to the ease of access to community
pharmacies compared to other healthcare services, expertise and knowledge of
pharmacists and patients' trust, misconceptions and inappropriate practices of
the public towards antibiotic use, customer pressure, pharmacists' need to ensure
business survival and weak regulatory enforcement mechanism. These are presented
in more detail below by using illustrative quotes from participants' transcripts.
CONCLUSIONS: The non-prescribed sale of antibiotics is still a common practice in
Saudi Arabia, despite being a problem. The results of this study highlight the
need to design interventions to promote rational use of antibiotics.
DOI: 10.1186/s12913-018-3753-y
PMCID: PMC6276151
PMID: 30509267 [Indexed for MEDLINE]
Author information:
(1)School of Psychology, University of Newcastle, Callaghan, 2280, NSW,
Australia.
(2)Schizophrenia Research Institute, 405 Liverpool St, Darlinghurst, 2010, NSW,
Australia.
(3)School of Medicine & Public Health, University of Newcastle, Callaghan, 2280,
NSW, Australia.
DOI: 10.1016/j.scog.2014.12.001
PMCID: PMC5779288
PMID: 29379758
Author information:
(1)Division of Epidemiology & Communicable Diseases, Indian Council of Medical
Research, New Delhi, India.
(2)Department of Infectious Diseases, Apollo Hospitals, Chennai, India.
Antimicrobial resistance (AMR) in India has become a great threat because of high
rate of infectious diseases. One of the key contributing factors is high
antibiotic use due to poor prescription practices, self-medication,
over-the-counter sale of drugs and lack of awareness. Antimicrobial stewardship
programme (AMSP) have been proved to be successful in restraining sale and use of
antibiotics to a large extent in many countries. An AMSP programme for a hospital
is imperative for rational and evidence-based antimicrobial therapy. The ultimate
aim is to improve patient outcomes, reduce emergence of bacterial resistance and
ensure longevity of the existing antimicrobials. The primary goal of AMSP is to
encourage cautious use of available antibiotics by training the healthcare
workers and creating awareness. This article describes the strategies and
recommendations for formulation of AMSP policy for India.
DOI: 10.4103/ijmr.IJMR_147_18
PMCID: PMC6563731
PMID: 31219081
Multivitamin and protein supplement use is associated with positive mood states
and health behaviors in US Military and Coast Guard personnel.
Author information:
(1)From the *US Army Research Institute of Environmental Medicine, Natick, MA;
and †Oak Ridge Institute for Science and Education, Belcamp, MD.
Approximately 60% of Armed Forces personnel regularly consume dietary supplements
(DSs). We investigated the association of mood and health behaviors with multiple
classes of DSs in military and Coast Guard personnel (N = 5536). Participants
completed a survey of DS use and the Quick Mood Scale to assess mood domains of
wakeful-drowsiness, relaxed-anxious, cheerful-depressed, friendly-aggression,
clearheaded-confused, and well coordinated-clumsy. Supplements were categorized
as multivitamin/minerals (MVM), individual vitamin/minerals, protein/amino acid
supplements (PS), combination products (C), herbals (H), purported steroid
analogs, (S) and other (O). One-way analyses of covariance assessed associations
of DSs and perceived health behavior with mood controlling for age. Logistic
regression determined associations between DS use and health behavior. Users of
MVM and PS reported feeling significantly (P < 0.05) more awake, relaxed,
cheerful, clearheaded, and coordinated. Participants using PS and S reported
feeling less friendly (more aggressive, P < 0.02). Users of MVM and PS were more
likely to report their general health, eating habits, and fitness level as
excellent/good (P < 0.05). Participants reporting health behaviors as
excellent/good were more (P < 0.01) awake, relaxed, cheerful, friendly,
clearheaded, and coordinated. As no known biological mechanisms can explain such
diverse effects of MVM and PS use on multiple mood states, health, eating habits,
and fitness, we hypothesize these associations are not causal, and DS intake does
not alter these parameters per se. Preexisting differences in mood and other
health-related behaviors and outcomes between users versus nonusers of DSs could
be a confounding factor in studies of DSs.
DOI: 10.1097/JCP.0000000000000193
PMCID: PMC4165472
PMID: 25122181 [Indexed for MEDLINE]
Author information:
(1)Department of Biology University of North Carolina at Greensboro Greensboro
North Carolina.
DOI: 10.1002/ece3.4989
PMCID: PMC6580263
PMID: 31236255
Author information:
(1)Ph. D. Epidemiology and Dr. Public Health. Faculty of Medicine, Universidad
Nacional de Colombia, Bogotá, Colombia. mvvalerober@unal.edu.co.
(2)MD. Ph. D. Epidemiology. Dhc. Director-Emeritus, Swiss Tropical and Public
Health Institute, University of Basel. President, Academia of Sciences. Basel,
Switzerland. Marcel.tanner@unibas.ch.
(3)Biostatistician. Ph. D. Biostatistics. Director, School of Public Health.
Faculty of Medicine, Universidad de La Frontera. Temuco, Chile.
sergio.munoz.n@ufrontera.cl.
(4)MD. Anesthesiologist. Surgery Department Anesthesiology Unit, Faculty of
Medicine, Universidad Nacional de Colombia. Bogotá, Colombia.
jfvalerob@unal.edu.co.
Author information:
(1)Pharmaco-Business Innovation Laboratory, Graduate School of Pharmaceutical
Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033
Japan.
DOI: 10.1186/s40064-015-1549-7
PMCID: PMC4661161
PMID: 26640749
Author information:
(1)Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.
DOI: 10.15288/jsad.2015.76.781
PMCID: PMC4714828
PMID: 26402359 [Indexed for MEDLINE]
Tull MT(1), Bardeen JR(2), DiLillo D(3), Messman-Moore T(4), Gratz KL(5).
Author information:
(1)Department of Psychiatry and Human Behavior, University of Mississippi Medical
Center, Jackson, MS, USA. Electronic address: mtull@umc.edu.
(2)Department of Psychology, Auburn University, Auburn, AL, USA.
(3)Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.
(4)Department of Psychology, Miami University, Oxford, OH, USA.
(5)Department of Psychiatry and Human Behavior, University of Mississippi Medical
Center, Jackson, MS, USA.
DOI: 10.1016/j.janxdis.2014.11.003
PMCID: PMC4749400
PMID: 25483275 [Indexed for MEDLINE]
Author information:
(1)Institute of Child Health, College of Medicine, University of Ibadan, Ibadan,
Nigeria.
DOI: 10.4103/2249-4863.154655
PMCID: PMC4408706
PMID: 25949972
472. Patient Prefer Adherence. 2015 Aug 24;9:1219-24. doi: 10.2147/PPA.S89258.
eCollection 2015.
Ajah LO(1), Onubogu ES(1), Anozie OB(1), Lawani LO(1), Iyoke CA(2), Onwe EO(3),
Ajah MI(4).
Author information:
(1)Department of Obstetrics and Gynaecology, Federal Teaching Hospital,
Abakaliki, Nigeria.
(2)Department of Obstetrics and Gynaecology, University of Nigeria Teaching
Hospital, Ituku-Ozalla, Nigeria.
(3)Department of Paediatrics, Abakaliki, Nigeria.
(4)Well Women Centre, Federal Teaching Hospital, Abakaliki, Nigeria.
DOI: 10.2147/PPA.S89258
PMCID: PMC4556251
PMID: 26346663
473. Pharmacy (Basel). 2019 Jun 20;7(2). pii: E73. doi: 10.3390/pharmacy7020073.
Seubert LJ(1), Kerry W(2), Laetitia H(3)(4), Watson MC(5), Clifford RM(6).
Author information:
(1)Division of Pharmacy, The University of Western Australia, M315, 35 Stirling
Highway, Crawley WA 6009, Australia. liza.seubert@uwa.edu.au.
(2)Division of Pharmacy, The University of Western Australia, M315, 35 Stirling
Highway, Crawley WA 6009, Australia. kerry.whitelaw@uwa.edu.au.
(3)School of Pharmacy and Pharmacology, Griffith University, Gold Coast Campus,
Queensland 4222, Australia. l.hattingh@griffith.edu.au.
(4)Gold Coast Health, Griffith University, Gold Coast, Queensland 4215,
Australia. l.hattingh@griffith.edu.au.
(5)Watson Research and Training Ltd., Aberdeen AB15 8FL, Scotland.
magswatsonbusiness@gmail.com.
(6)Division of Pharmacy, The University of Western Australia, M315, 35 Stirling
Highway, Crawley WA 6009, Australia. rhonda.clifford@uwa.edu.au.
DOI: 10.3390/pharmacy7020073
PMCID: PMC6630978
PMID: 31226837
Eye health seeking habits and barriers to accessing curative services among blind
beggars in an urban community in Northern Nigeria.
Author information:
(1)Department of Ophthalmology, Federal Medical Centre, Birnin-Kebbi, Nigeria.
OBJECTIVE: The aim of the following study was to determine the types of
intervention sought by the blind street beggars and assess the barriers to
accessing available eye care services.
METHODS: This cross-sectional study was conducted among consenting blind street
beggars in Sokoto, Nigeria between May and June, 2009. A semi-structured
interview was conducted to probe issues on historical antecedents of the
blindness and the eye heath seeking behavior including the use of traditional eye
medications. Assessment of barriers to accessing curative services among the
blind persons was explored. Questions were asked and the individual responses
were recorded in the questionnaire under the appropriate sections.
RESULTS: Two hundred and two of 216 (94.7%) of the examined subjects were found
to be blind and included in the analysis. The principal cause of blindness was
corneal opacity. Overall 82% of the blindness was due to avoidable causes with
majority irreversibly blind. Only 38 subjects (18.8%) sought for intervention in
hospitals, others resorted to self-medication (42.1%), medicine store (31.2%) and
traditional facility (7.9%). Those that accessed treatment at a hospital did so
mainly at a primary health center (50.0%) and General Hospitals (34.2%). The
barriers to accessing treatment at the hospital were mainly due to "not taken to
any hospital" by the parents/relatives (50.3%) and "services not available"
(25.2%).
CONCLUSION: Most respondents resorted to ocular self-medication particularly
traditional eye medicines. We advocate for a provision of affordable, accessible
and qualitative eye care services with a strong health education component on
avoidable causes of blindness.
DOI: 10.4103/1596-3519.142289
PMID: 25287032 [Indexed for MEDLINE]
Author information:
(1)Centre of Medicine Information and Pharmaceutical Care, University of
Surabaya, Surabaya (Indonesia). cecilia.brata@gmail.com.
(2)Faculty of Pharmacy, University of Sydney. Sydney, NSW (Australia).
carl.schneider@sydney.edu.au.
(3)School of Medicine, University of Western Sydney. Sydney, NSW (Australia).
B.Marjadi@westernsydney.edu.au.
(4)School of Medicine and Pharmacology, University of Western Australia. Perth,
WA (Australia). rhonda.clifford@uwa.edu.au.
DOI: 10.18549/PharmPract.2019.2.1452
PMCID: PMC6594425
PMID: 31275500
476. BMC Complement Altern Med. 2019 Aug 2;19(1):196. doi: 10.1186/s12906-019-2602-
9.
Peacock M(1), Badea M(2), Bruno F(3), Timotijevic L(4), Laccisaglia M(3),
Hodgkins C(4), Raats M(4), Egan B(4).
Author information:
(1)Food, Consumer Behaviour and Health Research Centre, School of Psychology,
Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH,
UK. m.peacock@surrey.ac.uk.
(2)Department of Fundamental, Prophylactic and Clinical Specialties, Faculty of
Medicine, Transylvania University of Brasov, Bdul Eroilor Nr 29, 500039, Brasov,
Romania.
(3)Centre of Studies in Drug Communication, Department of Pharmacological and
Biomolecular Sciences, Pharmaceutical Sciences, University Of Milan, Via
Balzaretti 9, 20133, Milan, MI, Italy.
(4)Food, Consumer Behaviour and Health Research Centre, School of Psychology,
Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH,
UK.
DOI: 10.1186/s12906-019-2602-9
PMCID: PMC6679444
PMID: 31375101
Losappio L(1), Heffler E(2)(3), Carpentiere R(4), Fornero M(1), Cannito CD(4),
Guerrera F(5), Puggioni F(2)(3), Monti R(6), Nicola S(6), Rolla G(6), Brussino
L(7).
Author information:
(1)Allergy and Immunology Department, Niguarda Ca Granda Hospital, Milan, Italy.
(2)Personalized Medicine, Asthma and Allergy, Humanitas Research Hospital,
Rozzano, Italy.
(3)Department of Biomedical Sciences, Humanitas University, Rozzano, Italy.
(4)Emergency Department, "Dimiccoli" Hospital, Barletta, Italy.
(5)Department of Surgical Science, University of Torino, Torino, Italy.
(6)Allergy and Clinical Immunology Unit, Department of Medical Science,
University of Torino and AO Ordine Mauriziano Umberto I, Torino, Italy.
(7)Allergy and Clinical Immunology Unit, Department of Medical Science,
University of Torino and AO Ordine Mauriziano Umberto I, Torino, Italy.
luisa.brussino@unito.it.
DOI: 10.1186/s12890-019-0869-8
PMCID: PMC6580601
PMID: 31208388
478. Fertil Res Pract. 2018 Apr 13;4:2. doi: 10.1186/s40738-018-0047-3. eCollection
2018.
Author information:
(1)1Faculty of Health Sciences, University of Buea and Department of Obstetrics
and Gynecology, Douala General Hospital, P.O. Box 63, Buea, Cameroon.
(2)Department of Obstetrics and Gynecology, Douala General Hospital, Douala,
Cameroon.
(3)Department of Anesthesiology and Reanimation, Douala General Hospital, Douala,
Cameroon.
(4)Faculty of Medicine and Biomedical Sciences, University of Yaounde 1 and
Department of Obstetrics and Gynecology, Douala General Hospital, Douala,
Cameroon.
DOI: 10.1186/s40738-018-0047-3
PMCID: PMC5898046
PMID: 29686882
Author information:
(1)Aarhus University. amafenny@yahoo.co.uk.
Health insurance is attracting more and more attention as a means for improving
health care utilization and protecting households against impoverishment from
out-of-pocket expenditures. Currently about 52 percent of the resources for
financing health care services come from out of pocket sources or user fees in
Africa. Therefore, Ghana serves as in interesting case study as it has
successfully expanded coverage of the National Health Insurance Scheme (NHIS).
The study aims to establish the treatment-seeking behaviour of households in
Ghana under the NHI policy. The study relies on household data collected from
three districts in Ghana covering the 3 ecological zones namely the coastal,
forest and savannah.Out of the 1013 who sought care in the previous 4 weeks, 60%
were insured and 71% of them sought care from a formal health facility. The
results from the multinomial logit estimations show that health insurance and
travel time to health facility are significant determinants of health care
demand. Overall, compared to the uninsured, the insured are more likely to choose
formal health facilities than informal care including self-medication when ill.
We discuss the implications of these results as the concept of the NHIS grows
widely in Ghana and serves as a good model for other African countries.
DOI: 10.5539/gjhs.v7n1p296
PMCID: PMC4796516
PMID: 25560361 [Indexed for MEDLINE]
The aim of this review was to assess public knowledge and behaviours in relation
to antibiotic use in GCC countries. A systematic review was performed using
MEDLINE, EMBASE and other relevant databases. Cross-sectional studies published
from January 2000 to June 2017 relating to public knowledge and behaviours
towards antibiotic use were included. Overall nine studies met the inclusion
criteria for this systematic review. Nearly half of general public respondents in
the GCC region reported a lack of knowledge about antibiotic use and showed
negative attitudes towards antibiotic utilisation. Penicillin was the most
frequently misused antibiotic, particularly for self-medication. Most respondents
declared that they obtained information on antibiotics from pharmacists.
Pharmacies were the major source of antibiotics used for self-medication. A
multi-disciplinary approach must be put in place to educate the public on
appropriate antibiotic use, to improve policies regarding the rational
prescription of antimicrobials and to increase regulation enforcement.
Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.jiph.2018.09.002
PMID: 30245158 [Indexed for MEDLINE]
481. Front Vet Sci. 2019 Mar 15;6:72. doi: 10.3389/fvets.2019.00072. eCollection
2019.
Author information:
(1)BOA, INRA, Université de Tours, Nouzilly, France.
(2)PRC, CNRS, IFCE, INRA, Université de Tours, Nouzilly, France.
The postnatal period is critical for broiler chicks as they are exposed to
potentially stressful environmental changes in the hatchery and during
transportation to the rearing houses. The ability of broiler chicks to
spontaneously drink essential oils (EO) to mitigate the effects of a negative
postnatal experience was tested. Chicks were placed in the rearing facility
either immediately (C group), or after a 24 h-delay period (D group) to mimic a
delay in transportation possible under commercial conditions. In experiment 1,
each group had access to either water only or to water and one EO (cardamom,
marjoram, or verbena) from D1 to D13. Verbena EO intake was higher in the D group
than in the C group from D1 to D6 and cardamom EO intake was lower in the D group
than in the C group from D6 to D13. In experiment 2, half of the groups had
access to water only and the other half had both water and the three EO
simultaneously. Chicks from D and C groups chose the EO similarly except for
cardamom EO with a lower intake being observed in the D than in the C group from
D6 to D12. The delayed placement of the D group reduced chicken growth until 34
days of age and temporarily increased the feed conversion ratio, but did not
affect their welfare or the prevalence of health disorders. The EO intake did not
mitigate the growth reduction in D group chicks, but did mitigate the reduced
Pectoralis major muscle yield. In conclusion, chicks were able to make
spontaneous choices regarding EO intake according to their postnatal experience
when EO were presented individually, but not when presented simultaneously as in
our experimental design. The EO intake only partially mitigated the decrease in
chicken performance after the negative postnatal experience.
DOI: 10.3389/fvets.2019.00072
PMCID: PMC6428774
PMID: 30931317
Author information:
(1)Department of Psychiatry, Sikkim Manipal Institute of Medical Sciences, Sikkim
Manipal University, Gangtok, Sikkim, India.
(2)Department of Psychiatry and Head of the Department, Sikkim Manipal Institute
of Medical Sciences, Sikkim Manipal University, Gangtok, Sikkim, India.
(3)Department of Psychiatry, Department, Sikkim Manipal Institute of Medical
Sciences, Sikkim Manipal University, Gangtok, Sikkim, India.
Background: People with opioid use disorder have significant anxiety and
depression which can be because of neuroplastic changes due to use of opioid or
because of use as a self-medication to relieve depression and anxiety. During the
last one decade, opioid use has reached an alarming proportion in Sikkim, India;
but, any research related to anxiety and depression among opioid users has not
been done.
Aims: To assess for depression and anxiety disorders among the opioid dependence
syndrome (ODS) participants and its severity, and to find the association with
the sociodemographic characteristics.
Method: One hundred participants from three different drug detoxification and
rehabilitation centres who were diagnosed with ODS as per the ICD-10, Diagnostic
Criteria for Research were assessed cross-sectionally with the Addiction Severity
Index to find out the substances abused and psychiatric morbidity. Anxiety,
depression, and mania were graded with the Hamilton rating scales for anxiety and
depression, and the Young Mania Rating Scale.
Results: Mean age of participants was 29.6 (±6.24) years. Ninety six per cent
were males. Most of the participants were using multiple opioid preparations.
Thirty four per cent were using dextropropoxyphene containing pain killer
followed by six per cent using codeine containing cough syrup. Eighty two per
cent had depression; however, only 13% were found to have severe depression.
Fifty six per cent had anxiety and six per cent were found to have mania. Most of
the participants with ODS were single, attended at least secondary education,
from urban locality, and were from high socioeconomic status.
Conclusion: anxiety and depression are highly prevalent among ODS people.
Treatment should not be limited to management of ODS but also the comorbid
psychiatric illness.
DOI: 10.5958/2394-2061.2019.00030.2
PMCID: PMC6602083
PMID: 31263773
Author information:
(1)Mind-Brain Group, Institute for Culture and Society, University of Navarra,
Pamplona, Spain.
(2)Faculty of Education and Psychology, University of Navarra, Pamplona, Spain.
(3)Department of Health Sciences, Public University of Navarra, Pamplona, Spain.
(4)Department of Psychobiology and Research Center for Mind, Brain, and Behavior
(CIMCYC), University of Granada, Granada, Spain.
DOI: 10.3389/fpsyt.2019.00421
PMCID: PMC6588127
PMID: 31258496
Author information:
(1)Institute for Population and Social Research, Mahidol University, Salaya,
Nakhon Pathom, Thailand.
(2)Institute for Population and Social Research, Mahidol University, Salaya,
Nakhon Pathom, Thailand. sureeporn.pun@mahidol.ac.th.
(3)Department of Epidemiology and Global Health, Umeå University, Umeå, Sweden.
(4)Department of Public Health Sciences, Global Health (IHCAR), Karolinska
Institutet, Stockholm, Sweden.
(5)Oxford University Clinical Research Unit, Hanoi, Vietnam.
(6)The Nuffield Department of Medicine, University of Oxford, Oxford, UK.
(7)Department of Clinical Microbiology and the Radboud Center for Infectious
Diseases, Radboudumc, Nijmegen, Netherlands.
DOI: 10.1186/s12889-019-7300-5
PMCID: PMC6647088
PMID: 31331304
Author information:
(1)Centre for Research on Health and Social Care Management (CERGAS) SDA Bocconi
School of Management, Milan, Italy.
(2)Department of Social and Political Sciences, Bocconi University, Milan, Italy.
(3)Federchimica Assosalute, Milan, Italy.
(4)Department of Pharmaceutical Sciences, Università del Piemonte Orientale,
Novara, Italy.
Erratum for
Front Pharmacol. 2018 Oct 17;9:1069.
[This corrects the article DOI: 10.3389/fphar.2018.01069.].
DOI: 10.3389/fphar.2019.00129
PMCID: PMC6412142
PMID: 30890931
486. Toxins (Basel). 2019 Apr 22;11(4). pii: E234. doi: 10.3390/toxins11040234.
Author information:
(1)School of Biological Sciences, Illinois State University, Normal, IL 61790,
USA. dwwhitm@ilstu.edu.
(2)Instituto de Ciencias Agrarias, CSIC, Serrano 115-dpdo, 28006 Madrid, Spain.
mafay@ica.csic.es.
(3)Facultad de Medicina, Universidad Autónoma de Madrid (UAM), Arzobispo Morcillo
S/N, 28029 Madrid, Spain. rafael.martinez@uam.es.
(4)Facultad de Farmacia, Universidad Complutense de Madrid (UCM), CEI Campus
Moncloa, 28040 Madrid, Spain. alexandraibanez@ucm.es.
(5)Facultad de Veterinaria, Universidad Complutense (UCM), 28040 Madrid, Spain.
angeles@ucm.es.
(6)Instituto de Ciencias Agrarias, CSIC, Serrano 115-dpdo, 28006 Madrid, Spain.
azu@ica.csic.es.
DOI: 10.3390/toxins11040234
PMCID: PMC6521026
PMID: 31013660
DOI: 10.1371/journal.pone.0216115
PMCID: PMC6488076
PMID: 31034528
488. Int J Environ Res Public Health. 2019 Jan 25;16(3). pii: E335. doi:
10.3390/ijerph16030335.
Wang W(1), Wang X(2), Hu YJ(3), Wu D(4), Lu J(5), Xu Y(6), Sun C(7), Zhou X(8).
Author information:
(1)Institute for Social Medicine and Family Medicine, School of Medicine,
Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
weiyiwang@zju.edu.cn.
(2)Institute for Social Medicine and Family Medicine, School of Medicine,
Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
ellen_wang@zju.edu.cn.
(3)School of Public Health, The University of Hong Kong, 7 Sassoon Road, Pokfulam
10000, Hong Kong. jesshu17@hku.hk.
(4)The University of North Carolina at Chapel Hill Project-China, 2 Lujing Road,
Guangzhou, 510095, China. denisewd@163.com.
(5)Institute for Social Medicine and Family Medicine, School of Medicine,
Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
jingjinglu@zju.edu.cn.
(6)Institute for Social Medicine and Family Medicine, School of Medicine,
Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
seanxuzju@zju.edu.cn.
(7)Institute for Social Medicine and Family Medicine, School of Medicine,
Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
sunchenhui@zju.edu.cn.
(8)Institute for Social Medicine and Family Medicine, School of Medicine,
Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
zhouxudong@zju.edu.cn.
DOI: 10.3390/ijerph16030335
PMCID: PMC6388115
PMID: 30691066 [Indexed for MEDLINE]
489. Int J Gen Med. 2019 Jun 28;12:235-246. doi: 10.2147/IJGM.S200641. eCollection
2019.
Jairoun A(1), Hassan N(1), Ali A(1), Jairoun O(2), Shahwan M(1), Hassali M(3).
Author information:
(1)College of Pharmacy and Health Sciences, Ajman University, Ajman, UAE.
(2)College of Dentistry, Ajman University, Ajman, UAE.
(3)Discipline of Social and Administrative Pharmacy, School of Pharmaceutical
Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Purpose: Antibiotic resistance is one of the world's most fatal health crises.
Medical students are the antibiotic prescribers of tomorrow, so better
understanding of their knowledge, attitudes, and practice (KAP) pertaining to
antibiotic use is crucial. Objectives: This study aimed to assess the KAP of
antibiotics and associated factors among university students in the United Arab
Emirates (UAE). Methods: This was a descriptive cross-sectional study conducted
among a random sample of undergraduate students from Ajman University in the UAE.
A self-administered pretested questionnaire was used to collect data on students'
demographics and their KAP regarding antibiotic use. Data were analysed using
STATA version 14.2. P<0.05 was considered statistically significant. Results:
This study showed that university students have a high rate of antibiotic
self-medication. The average KAP score was 56% (95% CI 55%-57%). Statistical
modeling showed that major, study year, age, and sex were strong determinants of
KAP regarding antibiotic use. Conclusion: There is a need to develop an effective
and comprehensive antibiotic-stewardship program as part of undergraduate
education. Moreover, reinforcing antibiotic-use policies, involving pharmacies,
drug supply, distribution, and sale, are also urgently needed.
DOI: 10.2147/IJGM.S200641
PMCID: PMC6607982
PMID: 31388309
Epp DA(1)(2), Kubota T(3), Yoshida M(4), Kishimoto J(5), Kobayashi D(2), Shimazoe
T(2).
Author information:
(1)Center for Advancing Pharmaceutical Education, Daiichi University of Pharmacy,
Fukuoka, Japan.
(2)Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
(3)Center of Pharmaceutical Care for Community Health, Daiichi University of
Pharmacy, Fukuoka, Japan.
(4)Faculty of Medicine, International University for Health and Welfare, Narita,
Japan.
(5)Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Objective. The purpose of this study was to teach communication skills for
patient care to pre-clerkship students and observe changes in student
perspectives towards communication from pre- to post-training. Methods. Two
cohorts of fourth-year pharmacy students completed an eight-week pre-clerkship
training course designed to improve their communication skills. The course
involved class discussions and in-class research of medications, practicing
communication skills, learning to give science-based responses, and developing an
awareness of patient education for lifestyle, self-medication, quality of life,
and medication adherence. A comparison of students' pre- and post-training
responses to a questionnaire were used to assess changes in students' ability and
confidence in communicating with patients. An exploratory factor analysis was
used to analyze and compare the data results. Results. Students' mean
post-training scores for perceived ability to make small talk and confidence to
communicate with patients increased compared to pre-training scores. Based on the
results of the exploratory factor analysis, the greatest increase in students'
scores was in the area of patient education skills. Conclusion. The pre-clerkship
communication training improved student understanding of the pharmacy
communication skills needed to conduct effective patient education and
pharmacist-patient interaction beyond dispensing, affirming the theory that
specialized communication training before students' begin a clerkship may be
essential.
DOI: 10.5688/ajpe6745
PMCID: PMC6630866
PMID: 31333251
Atif M(1), Asghar S(1), Mushtaq I(2), Malik I(1), Amin A(1), Babar ZU(3), Scahill
S(4).
Author information:
(1)Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur,
Pakistan, pharmacist_atif@yahoo.com.
(2)Department of Education, The Islamia University of Bahawalpur, Bahawalpur,
Pakistan.
(3)Department of Pharmacy, University of Huddersfield, Huddersfield, UK.
(4)School of Management, Massey Business School, Massey University, Auckland, New
Zealand.
Purpose: This study investigates the knowledge, attitudes and practices of the
general public regarding the use of antibiotics in community pharmacy, in
Pakistan.
Methods: This is a mixed method study where data were collected through a
validated questionnaire and semi-structured interviews. Convenience sampling
techniques were used to recruit participants from the general public of
Bahawalpur, Pakistan who visited pharmacies to purchase antibiotics between 1
June 2018 and 31 July 2018. Descriptive statistics and regression analyses were
used to tabulate the results of quantitative data while inductive thematic
analysis was used to identify themes and draw conclusions from the qualitative
data.
Results: Over 60% of the 400 survey participants (n=246; 61.5%) had a moderate
level of antibiotic knowledge; however, attitudes regarding antibiotics use were
poor in half the sample (n=201; 50.3%). More than half (n=226; 56.6%) of the
respondents stated that antibiotics could cure all types of infections. Just
under one third (n=129; 32.3%) of respondents obtained the appropriate dosage
regimen while the majority did not complete the course (n=369; 92.3%); stopping
when they felt better. Inductive thematic analysis yielded four themes, 10
subthemes and 27 categories. Two subthemes were related to knowledge, one to
attitude, three to practices and four subthemes were related to suggestions to
improve the healthcare system. Inappropriate antibiotic practices included: lack
of consultation with healthcare professionals, purchase of antibiotics without
prescription or refilling of previous prescription, use of home supply of
antibiotics, sharing of antibiotics with others, improper dosage regimens and
early cessation of antibiotic therapy.
Conclusion: Level of education, low health literacy, high consultation fees of
private practitioners, inadequate health facilities in government hospitals and
patient overload, busy schedules of people, poor healthcare infrastructure in
rural areas and unrestricted supply of antibiotics were key factors associated
with inappropriate use of antibiotics in Pakistan.
DOI: 10.2147/IDR.S189114
PMCID: PMC6440533
PMID: 30988635
492. BMC Health Serv Res. 2019 Jun 20;19(1):404. doi: 10.1186/s12913-019-4219-6.
Gauld NJ(1).
Author information:
(1)School of Pharmacy, The University of Auckland, Park Rd, Grafton, Auckland,
New Zealand. n.gauld@auckland.ac.nz.
DOI: 10.1186/s12913-019-4219-6
PMCID: PMC6587299
PMID: 31221154 [Indexed for MEDLINE]
493. Medicina (Kaunas). 2019 Jun 3;55(6). pii: E238. doi: 10.3390/medicina55060238.
Author information:
(1)Haematology, Oncology and Transfusion Medicine Centre, Vilnius University
Hospital Santaros Klinikos, Santariškių 2, LT-08661 Vilnius, Lithuania.
austeja.dapkeviciute@santa.lt.
(2)Institute of Clinical Medicine, Vilnius University, Santariškių 2, LT-08661
Vilnius, Lithuania. austeja.dapkeviciute@santa.lt.
(3)Institute of Clinical Medicine, Vilnius University, Santariškių 2, LT-08661
Vilnius, Lithuania. virginijus.sapoka@santa.lt.
(4)Quantitative Psychology Program, University of Virginia, 485 McCormick Road
Charlottesville, VA 22903, USA. em6gg@virginia.edu.
(5)Haematology, Oncology and Transfusion Medicine Centre, Vilnius University
Hospital Santaros Klinikos, Santariškių 2, LT-08661 Vilnius, Lithuania.
valdas.peceliunas@santa.lt.
(6)Institute of Clinical Medicine, Vilnius University, Santariškių 2, LT-08661
Vilnius, Lithuania. valdas.peceliunas@santa.lt.
DOI: 10.3390/medicina55060238
PMCID: PMC6631661
PMID: 31163661
Chai J(1)(2), Coope C(3)(4), Cheng J(1)(2), Oliver I(3)(4), Kessel A(5), Hu Z(1),
Wang D(2).
Author information:
(1)School of Public Health, Anhui Medical University, Hefei, China.
(2)School of Health Services Management, Anhui Medical University, Hefei, China.
(3)NIHR Health Protection Research Unit in Evaluation of Interventions, Bristol
Medical School, University of Bristol, Bristol, UK.
(4)National Infection Service, Public Health England, Bristol, UK.
(5)Faculty of Public Health and Policy, London School of Hygiene & Tropical
Medicine, London, UK.
Yagoub U(1), Al Qahtani B(2), Hariri IA(3), Al Zahrani A(4), Siddique K(1).
Author information:
(1)Research Department, Academic Affairs, King Salman Armed Forces Hospital
Northwestern Region, Tabuk 71411, Saudi Arabia.
(2)Department of Academic Affairs, King Salman Armed Forces Hospital Northwestern
Region, Tabuk 71411, Saudi Arabia.
(3)Department of Family Medicine, King Salman Armed Forces Hospital Northwestern
Region, Tabuk 71411, Saudi Arabia.
(4)Department of Surgery, King Salman Armed Forces Hospital Northwestern Region,
Tabuk 71411, Saudi Arabia.
Background: During the 21st century, antimicrobial resistance (AMR) has emerged
as one of the greatest public health challenges worldwide. In the coming 20
years, health care systems may be unable to treat bacterial diseases efficiently
due to this phenomenon. Objective: To determine the level of knowledge regarding
AMR among patients attending two hospitals in Tabuk city in northeast Kingdom of
Saudi Arabia (KSA). Materials and Methods: This cross-sectional study was
conducted at King Salman Armed Forces Hospital and King Khalid Armed Forces
Hospital in Tabuk city. The study participants were selected from different
outpatient departments using a simple random sampling technique. Data collection
was performed using a self-reported questionnaire. All of the questions were
closed-ended to facilitate study participation and were translated into Arabic.
The data were entered into SPSS version 22 for Windows, cleaned and managed
before analysis. Results: Our results showed that 26.85% of the respondents had
knowledge regarding antibiotic resistance. Knowledge regarding the use of
antibiotics for treating bacterial infection was good among participants (60%),
but responses related to viral infection indicated confusion (23.06%), and
misconceptions were observed. Several factors were significantly associated with
knowledge regarding AMR among participants: 1) the use of antibiotics in the last
year (OR: 2.102, CI: 0.654-6.754); 2) the discontinued use of antibiotics when
feeling better (OR: 8.285, CI: 3.918-17.523); 3) giving antibiotics to friends or
family members to treat the same illness ([False]: OR: 108.96, CI: 29.98-395.93)
and 4) asking doctors to prescribe antibiotics that had been previously
administered for the same symptoms (OR: 9.314, CI: 3.684-23.550). Conclusion: Our
results revealed a very high unawareness of AMR and its contributing factors
among the study participants. Thus, health education and awareness are highly and
urgently recommended to address AMR in the Tabuk area.
DOI: 10.2147/IDR.S200996
PMCID: PMC6605762
PMID: 31303774
No Free Lunch With Herbal Preparations: Lessons From a Case of Parkinsonism and
Depression Due to Herbal Medicine Containing Reserpine.
Author information:
(1)Department of Neurology and Neurophysiology, Medical Center, Faculty of
Medicine, University of Freiburg, Freiburg, Germany.
(2)Department of Nuclear Medicine, Medical Center, Faculty of Medicine,
University of Freiburg, Freiburg, Germany.
The increasing use of herbal medicines calls for a heightened awareness of their
potential side-effects. This especially pertains to western countries, where
patients tend to use herbal medicine as self-medication, often alongside regular
prescriptions, and physicians have less experience with their application. Here
we report a case in which Parkinsonism, depression, and an atypical finding
detected by dopamine transporter single-photon emission computed tomography were
all belatedly recognized as side-effects of herbal medicine. This only occurred
because one of its active ingredients, reserpine, has been extensively studied.
For most other herbal medicines, however, knowledge about side-effects remains
scarce or unavailable. Therefore, we suggest that physicians, when taking a
medication history, should actively ask for the use of any herbal preparations.
DOI: 10.3389/fneur.2019.00634
PMCID: PMC6591315
PMID: 31275227
Author information:
(1)Department of Pharmacy, Zhejiang Provincial People's Hospital.
(2)Department of Pharmacy, People's Hospital of Hangzhou Medical College,
Hangzhou.
(3)Department of Pharmacy, China-Japan Friendship Hospital, Beijing.
(4)Laboratory Medicine, The First People's Hospital of Yancheng City, Yancheng,
Jiangsu.
(5)Department of Nephrology, China-Japan Friendship Hospital, Beijing.
(6)College of Pharmacy, Jiangsu Vocational College of Medicine, Yancheng,
Jiangsu, China.
RATIONALE: Reports of acute kidney injury (AKI) associated with benzbromarone use
in patients with hyperuricemia (HUA) are rare so far.
PATIENT CONCERNS: We describe 2 unique clinical patterns in which benzbromarone
was a possible cause of AKI following self-medication for HUA. In case 1, a
45-year-old man developed AKI after taking 100 mg of benzbromarone. His serum
creatinine (Scr) increased to 2.3 mg/dL on day 2 after benzbromarone
administration. Ultrasound showed multiple small stones in both kidneys, and the
24-hour urine uric acid level was 3128 mg. In case 2, a 17-year-old male student
presented with AKI after self-administration of 50 mg of benzbromarone. His Scr
increased to 6.8 mg/dL on day 3 after benzbromarone administration. Ultrasound
showed multiple stones in the left kidney.
DIAGNOSIS: Both patients underwent renal biopsy, with findings of acute tubular
interstitial nephropathy in case 1 and acute tubular damage in case 2.
Drug-induced AKI was considered.
INTERVENTIONS: Both cases were treated supportively with intravenous hydration
only. In both patients, the Scr level recovered within 0.5 months and renal
function was normal 3 months after discharge.
LESSONS: Oral benzbromarone is widely used in Asian counties to treat HUA and the
adverse effects are mostly mild. However, clinicians should be alert for
benzbromarone-induced AKI. Moreover, uricosuric drugs should only be used after
exclusion of urolithiasis and other contraindications.
DOI: 10.1097/MD.0000000000015214
PMCID: PMC6485891
PMID: 30985721 [Indexed for MEDLINE]
Author information:
(1)Graduate School of Health, University of Technology Sydney, Ultimo, Australia.
(2)Emeritus Professor, The University of Sydney, Camperdown, Australia.
DOI: 10.2196/13973
PMCID: PMC6709938
PMID: 31400107
Bingham B(1), Moniruzzaman A(1), Patterson M(1), Distasio J(2), Sareen J(3),
O'Neil J(1), Somers JM(1).
Author information:
(1)Faculty of Health Sciences, Simon Fraser University, Burnaby, British
Columbia, Canada.
(2)Geography, University of Winnipeg, Winnipeg, Manitoba, Canada.
(3)Psychology and Community Health Sciences, University of Manitoba, Winnipeg,
Manitoba, Canada.
OBJECTIVES: Indigenous people in Canada are not only over-represented among the
homeless population but their pathways to homelessness may differ from those of
non-Indigenous people. This study investigated the history and current status of
Indigenous and non-Indigenous people experiencing homelessness and mental
illness. We hypothesised that compared with non-Indigenous people, those who are
Indigenous would demonstrate histories of displacement earlier in life, higher
rates of trauma and self-medication with alcohol and other substances.
DESIGN AND SETTING: Retrospective data were collected from a sample recruited
through referral from diverse social and health agencies in Winnipeg and
Vancouver.
PARTICIPANTS: Eligibility included being 19 years or older, current mental
disorder and homelessness.
MEASURES: Data were collected via interviews, using questionnaires, on
sociodemographics (eg, age, ethnicity, education), mental illness, substance use,
physical health, service use and quality of life. Univariate and multivariable
models were used to model the association between Indigenous ethnicity and
dependent variables.
RESULTS: A total of 1010 people met the inclusion criteria, of whom 439
self-identified as Indigenous. In adjusted models, Indigenous ethnicity was
independently associated with being homeless at a younger age, having a lifetime
duration of homelessness longer than 3 years, post-traumatic stress disorder,
less severe mental disorder, alcohol dependence, more severe substance use in the
past month and infectious disease. Indigenous participants were also nearly twice
as likely as others (47% vs 25%) to have children younger than 18 years.
CONCLUSIONS: Among Canadians who are homeless and mentally ill, those who are
Indigenous have distinct histories and current needs that are consistent with the
legacy of colonisation. Responses to Indigenous homelessness must be developed
within the context of reconciliation between Indigenous and non-Indigenous
Canadians, addressing trauma, substance use and family separations.
TRIAL REGISTRATION NUMBER: ISRCTN42520374, ISRCTN57595077, ISRCTN66721740.
DOI: 10.1136/bmjopen-2018-024748
PMCID: PMC6500294
PMID: 30962229
Jairoun A(1), Hassan N(2), Ali A(2), Jairoun O(3), Shahwan M(2).
Author information:
(1)College of Pharmacy and Health Sciences, Ajman University, Ajman, UAE.
Dr_ammar_91_@hotmail.com.
(2)College of Pharmacy and Health Sciences, Ajman University, Ajman, UAE.
(3)College of Dentistry, Ajman University, Ajman, UAE.
DOI: 10.1186/s12889-019-6878-y
PMCID: PMC6501289
PMID: 31060543 [Indexed for MEDLINE]
Author information:
(1)Disease Modelling Lab, Department of Mathematics, School of Natural Sciences,
Shiv Nadar University, Gautan Buddha Nagar, India. bm650@snu.edu.in.
(2)Disease Modelling Lab, Department of Mathematics, School of Natural Sciences,
Shiv Nadar University, Gautan Buddha Nagar, India. samit.b@snu.edu.in.
DOI: 10.1038/s41598-019-46078-y
PMCID: PMC6611849
PMID: 31278344
502. BJU Int. 2016 Feb;117(2):363-72. doi: 10.1111/bju.13218. Epub 2015 Jul 30.
O'Kelly F(1), Manecksha RP(1), Quinlan DM(2), Reid A(3), Joyce A(4), O'Flynn
K(4), Speakman M(4), Thornhill JA(2).
Author information:
(1)Department of Urological Surgery, Tallaght Hospital, Dublin, Ireland.
(2)Irish Society of Urology, Dublin, Ireland.
(3)Department of Occupational Health, Tallaght Hospital, Dublin, Ireland.
(4)The British Association of Urological Surgeons, London, UK.
© 2015 The Authors BJU International published by John Wiley & Sons Ltd on behalf
of BJU International.
DOI: 10.1111/bju.13218
PMID: 26178315 [Indexed for MEDLINE]
503. J Rural Med. 2018 May;13(1):64-71. doi: 10.2185/jrm.2959. Epub 2018 May 29.
Prevalence of hypertension and hypertension control rates among elderly adults
during the cold season in rural Northeast China: a cross-sectional study.
Kawazoe N(1)(2), Zhang X(3), Chiang C(1), Liu H(4), Li J(3), Hirakawa Y(1),
Aoyama A(1).
Author information:
(1)Department of Public Health and Health Systems, Nagoya University School of
Medicine, Japan.
(2)Department of Economics, Nagoya University of Commerce and Business, Japan.
(3)Department of Social Medicine and Health Service Management, Jilin University
School of Public Health, China.
(4)Department of Epidemiology and Biostatistics, Jilin University School of
Public Health, China.
DOI: 10.2185/jrm.2959
PMCID: PMC5981021
PMID: 29875899
Laar AK(1), Kwara A(2), Nortey PA(3), Ankomah AK(1), Okyerefo MPK(4), Lartey
MY(5).
Author information:
(1)Department of Population, Family, and Reproductive Health, School of Public
Health, University of Ghana, Accra, Ghana.
(2)Department of Medicine, Warren Alpert Medical School of Brown University,
Providence, RI, United States.
(3)Department of Epidemiology and Disease Control, School of Public Health,
University of Ghana, Accra, Ghana.
(4)Department of Sociology, University of Ghana, Accra, Ghana.
(5)Department of Medicine, University of Ghana School of Medicine and Dentistry,
University of Ghana, Accra, Ghana.
DOI: 10.3389/fpubh.2017.00115
PMCID: PMC5445137
PMID: 28603710
505. NPJ Prim Care Respir Med. 2014 Sep 18;24:14062. doi: 10.1038/npjpcrm.2014.62.
Author information:
(1)Nuffield Department of Primary Care Health Sciences, University of Oxford,
Oxford, UK.
(2)Oxford Centre of Respiratory Medicine, Oxford University Hospitals NHS Trust,
Churchill Hospital, Oxford, UK.
DOI: 10.1038/npjpcrm.2014.62
PMCID: PMC4498166
PMID: 25372181 [Indexed for MEDLINE]
Dysmenorrhea and Its Effects on School Absenteeism and School Activities among
Adolescents in Selected Secondary Schools in Ibadan, Nigeria.
Author information:
(1)MH Healthcare Ltd, Alegbe Close, Maryland, Lagos, Nigeria.
(2)Department of Community Medicine, College of Medicine, University of Ibadan,
Ibadan, Nigeria.
(3)Department of Community Health and Primary Health Care, Lagos State University
College of Medicine, Lagos, Nigeria.
DOI: 10.4103/nmj.NMJ_47_17
PMCID: PMC6496977
PMID: 31057207
Rigo L(1), Garbin RR(2), Rodrigues JLSA(3), Menezes-Júnior LR(4), Paranhos LR(5),
Barelli C(2).
Author information:
(1)Faculdade IMED de Passo Fundo, Passo Fundo, RS, Brazil.
(2)Universidade de Passo Fundo, Passo Fundo, Brazil.
(3)Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brazil.
(4)Prefeitura Municipal de Itabaiana, Itabaiana, SE, Brazil.
(5)Universidade Federal de Sergipe, Lagarto, SE, Brazil.
Wiss DA(1).
Author information:
(1)Fielding School of Public Health, University of California, Los Angeles, Los
Angeles, CA, United States.
The opioid crisis has reached epidemic proportions in the United States with
rising overdose death rates. Identifying the underlying factors that contribute
to addiction vulnerability may lead to more effective prevention strategies.
Supply side environmental factors are a major contributing component.
Psychosocial factors such as stress, trauma, and adverse childhood experiences
have been linked to emotional pain leading to self-medication. Genetic and
epigenetic factors associated with brain reward pathways and impulsivity are
known predictors of addiction vulnerability. This review attempts to present a
biopsychosocial approach that connects various social and biological theories
related to the addiction crisis. The emerging role of nutrition therapy with an
emphasis on gastrointestinal health in the treatment of opioid use disorder is
presented. The biopsychosocial model integrates concepts from several
disciplines, emphasizing multicausality rather than a reductionist approach.
Potential solutions at multiple levels are presented, considering individual as
well as population health. This single cohesive framework is based on the
interdependency of the entire system, identifying risk and protective factors
that may influence substance-seeking behavior. Nutrition should be included as
one facet of a multidisciplinary approach toward improved recovery outcomes.
Cross-disciplinary collaborative efforts, new ideas, and fiscal resources will be
critical to address the epidemic.
DOI: 10.3389/fpubh.2019.00193
PMCID: PMC6629782
PMID: 31338359
Prevalence of illicit drug use among medical students in Northern Greece and
association with smoking and alcohol use.
Papazisis G(1), Tsakiridis I(2), Koulas I(1), Siafis S(1), Dagklis T(2), Kouvelas
D(1).
Author information:
(1)Department of Clinical Pharmacology, Faculty of Medicine, Aristotle University
of Thessaloniki, Greece.
(2)3 Department of Obstetrics and Gynecology, Faculty of Medicine, Aristotle
University of Thessaloniki, Greece.
AIM: The aim of this study was to estimate the prevalence of illicit drug use
among medical students in Northern Greece, to identify the motivations for
cannabis use and also to investigate the possible associations with smoking and
alcohol misuse.
METHODS: A sample of undergraduate students completed an anonymous,
self-administered, web-based survey assessing lifetime and past-year illicit
substance use. To further evaluate the motivation to use, the responders were
classified into three subtypes (self-medication, recreational, and mixed). The
CAGE questionnaire and a question assessing binge drinking were also used.
Illicit substance use was correlated with age, gender, study year, CAGE and binge
drinking.
RESULTS: Five hundred and ninety-one undergraduate medical students completed the
survey. The lifetime prevalence of illicit drug use was 24.7 %, while the most
used drug was cannabis (22.2 %). The past-month prevalence of cannabis use was
8.1 %. Experimentation was the predominant reported motivation for its use, and
the recreational subtype was the most prevalent. Binge drinking behavior was
reported by 22.7 % of the sample, and the CAGE screening test was positive for
6.4 % of the students. Most students (80.4 %) characterized themselves as
non-smokers. In the multivariate analysis, lifetime use of illicit drugs was
significantly correlated with smoking and binge drinking. No associations were
found with gender, age, study year or CAGE.
CONCLUSION: Smoking and binge drinking were found to be risk factors for illicit
drug use, whereas no association was found with gender, age, study year and CAGE.
HIPPOKRATIA 2017, 21(1): 13-18.
PMCID: PMC5997020
PMID: 29904251
510. Trop Dis Travel Med Vaccines. 2016 Jun 1;2:8. doi: 10.1186/s40794-016-0024-y.
eCollection 2016.
Author information:
(1)Department of Pediatrics, Stony Brook Children's Hospital, Stony Brook, NY
USA.
(2)Universidad Técnica de Machala, Machala, Ecuador.
(3)Ministerio de Salud Publica, Machala, El Oro Ecuador.
(4)Facultad de Ingenieria Maritima, Ciencias Oceanicas y Recursos Naturales,
Escuela Superior Politécnica del Litoral (ESPOL), Guayaquil, Guayas Ecuador.
(5)Division of Nutritional Sciences, Cornell University, Ithaca, NY USA.
(6)Department of Geography, University of Florida, Gainesville, FL USA.
(7)Emerging Pathogens Institute, University of Florida, Gainesvillee, fl USA.
(8)Center for Global Health and Translational Science, State University of New
York Upstate Medical University, Syracuse, NY USA.
DOI: 10.1186/s40794-016-0024-y
PMCID: PMC5531027
PMID: 28883952
Hall FS(1), Der-Avakian A(2), Gould TJ(3), Markou A(2), Shoaib M(4), Young JW(5).
Author information:
(1)Department of Pharmacology and Experimental Therapeutics, College of Pharmacy
and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA. Electronic
address: frank.hall@utoledo.edu.
(2)Department of Psychiatry, University of California San Diego, La Jolla, CA,
USA.
(3)Department of Psychology, Temple University, Philadelphia, PA, USA.
(4)Institute of Neuroscience, Newcastle University, Newcastle, UK.
(5)Department of Psychiatry, University of California San Diego, La Jolla, CA,
USA; Research Service, VA San Diego Healthcare System, San Diego, CA, USA.
DOI: 10.1016/j.neubiorev.2015.06.004
PMCID: PMC4670824
PMID: 26054790 [Indexed for MEDLINE]
Genetic variants and early cigarette smoking and nicotine dependence phenotypes
in adolescents.
O'Loughlin J(1), Sylvestre MP(2), Labbe A(3), Low NC(4), Roy-Gagnon MH(5), Dugas
EN(6), Karp I(7), Engert JC(8).
Author information:
(1)Centre de recherche CHUM, Montreal, Quebec, Canada; Department of Social and
Preventive Medicine, University of Montreal, Montreal, Quebec, Canada; Institut
national de santé publique du Québec, Montreal, Quebec, Canada.
(2)Centre de recherche CHUM, Montreal, Quebec, Canada; Department of Social and
Preventive Medicine, University of Montreal, Montreal, Quebec, Canada.
(3)Department of Epidemiology, McGill University, Montreal, Quebec, Canada.
(4)Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
(5)Department of Epidemiology and Community Medicine, Faculty of Medicine,
University of Ottawa, Ottawa, Ontario, Canada.
(6)Centre de recherche CHUM, Montreal, Quebec, Canada.
(7)Centre de recherche CHUM, Montreal, Quebec, Canada; Department of Social and
Preventive Medicine, University of Montreal, Montreal, Quebec, Canada; Department
of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry,
University of Western Ontario, London, Ontario, Canada.
(8)Departments of Medicine and Human Genetics, McGill University, Montreal,
Quebec, Canada; Research Institute of the McGill University Health Center,
Montreal, Quebec, Canada.
DOI: 10.1371/journal.pone.0115716
PMCID: PMC4278712
PMID: 25545355 [Indexed for MEDLINE]
The role of health insurance in the coverage of oral health care in Senegal.
Diop M(1), Kanouté A(2), Diouf M(1), Ndiaye AD(1), Lo CMM(1), Faye D(1), Cissé
D(1).
Author information:
(1)Department of Public Health Faculty of Medicine.
(2)Department of Odontology, Faculty of Medicine, Pharmacy and
Odonto-Stomatology, University Cheikh Anta Diop of Dakar, Senegal.
Oral diseases costs are among the most expensive health care benefits. In
Senegal, households contribute up to 37.6% of the national health spending
through direct payments. The aim of this work was to study the role of health
insurance in the coverage of oral health care in Senegal. The study was based on
health insurance agents and policyholders. The study reveals that oral health
care coverage through health insurance still does not meet requirements for
treatment of oral infections. In financial terms, oral health care costs health
insurance too much. As a result, carriers cover them partially. On top of that,
the majority of the population's lack of knowledge about mutual, because they
have a little background on oral health care, the latter weighs heavily on health
insurance leading to the use of self-medication, traditional medicine and
handicraft prosthetists. The analysis reveals an unequal access to oral health
care through the health insurance system. To bring under control the expenditure
for oral health care, carriers and dental surgeons must work together to raise
the populations' awareness on community solidarity.
DOI: 10.4081/jphia.2018.772
PMCID: PMC6379686
PMID: 30854174
Author information:
(1)Laboratório de Radio e Fotobiologia, Departamento de Biofísica e Biometria,
IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
(2)Laboratório de Radiobiologia Molecular, Universidade Federal do Rio de
Janeiro, Rio de Janeiro, RJ, Brasil.
DOI: 10.4238/2014.November.27.13
PMID: 25501195 [Indexed for MEDLINE]
Self-care behavior when suffering from the common cold and health-related quality
of life in individuals attending an annual checkup in Japan: a cross-sectional
study.
Shaku F(1), Tsutsumi M(2), Miyazawa A(3), Takagi H(4), Maeno T(5).
Author information:
(1)Department of Internal Medicine, Division of Respiratory Medicine, Nihon
University, 30-1 Oyaguchikamimachi, Itabashiku, Tokyo, 173-8610, Japan.
shaku-gi@umin.ac.jp.
(2)Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
madoka@md.tsukuba.ac.jp.
(3)Graduate School of Comprehensive Human Sciences, University of Tsukuba,
Tsukuba, Japan. tulip_with_freesia@yahoo.co.jp.
(4)Yamato clinic, Sakuragawa, Japan. rjmhw904@ybb.ne.jp.
(5)Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
maenote@md.tsukuba.ac.jp.
BACKGROUND: The World Health Organization and several governments encourage
medical self-care (including self-medication) for minor illnesses. Accordingly,
the factors that influence self-care have received research attention, with
socioeconomic status identified as one such predictor. Although studies have
examined the relationship between socioeconomic status and quality of life (QOL)
in patients suffering from respiratory allergies or chronic illnesses, the
relationship between QOL and self-care behavior for the common cold, the most
common illness seen in primary care, has not been examined. Therefore, we
investigated the relationship between QOL and self-care behavior in individuals
suffering from the common cold.
METHODS: We distributed questionnaires to 499 people who attended an annual
public health checkup in Kasama city, Japan. Valid questionnaires were received
from 398 participants (mean age = 59.0, SD = 15.8, range = 24-87 years; 61.4 %
women). The materials included a question relating to typical actions taken when
treating a common cold (self-care or visiting a health clinic), demographics, and
the Short Form-8™ (SF-8™)-an 8-item survey that assesses health-related quality
of life (HRQOL). The association of care action and HRQOL were investigated using
Mann-Whitney U tests with a significance level of p < 0.05.
RESULTS: The mean scores for the Physical Functioning, Role-Physical, Bodily
Pain, Social Functioning, Role-Emotional, and Physical Component Summary score of
the SF-8™ were significantly higher among the self-care group than the group that
preferred visiting a clinic.
CONCLUSIONS: HRQOL among individuals who engage in self-care when treating the
common cold was observed to be significantly higher than among individuals who
preferred to attend a health clinic. It is unclear whether self-care behavior
affects QOL, or whether QOL affects self-care behavior; however, this finding
highlights the importance of the relationship between QOL and self-care behavior.
Additional studies should be conducted in order to investigate the direction of
causality between self-care behaviors and QOL further.
DOI: 10.1186/s12875-015-0300-3
PMCID: PMC4518653
PMID: 26219348 [Indexed for MEDLINE]
Author information:
(1)Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The
University of Jordan (UJ), Amman, Jordan.
(2)Department of Clinical Pharmacy and Therpeutics, Faculty of Pharmacy, Applied
Science Private University, Amman, Jordan.
(3)Public Health Institute, Liverpool John Moore's University, United Kingdom.
DOI: 10.1016/j.jsps.2018.01.012
PMCID: PMC5856951
PMID: 29556121
Author information:
(1)Department of Community Medicine, Jorhat Medical College, Jorhat, Assam,
India.
DOI: 10.4103/2249-4863.220030
PMCID: PMC5749084
PMID: 29302545
Author information:
(1)ISGlobal, Barcelona Centre for International Health Research (CRESIB) Hospital
Clínic, Universitat de Barcelona, Barcelona, Spain.
(2)Centre for Social Science and Global Health University of Amsterdam,
Amsterdam, The Netherlands.
DOI: 10.1371/journal.pone.0136315
PMCID: PMC4552793
PMID: 26317781 [Indexed for MEDLINE]
519. Caspian J Intern Med. 2018 Winter;9(1):87-91. doi: 10.22088/cjim.9.1.87.
Stimulant use in medical students and residents requires more careful attention.
Author information:
(1)1.Student Research Committee, Babol University of Medical Sciences, Babol,
Iran.
(2)2.Cancer Research Center, Health Research Institute, Babol University of
Medical Sciences, Babol, Iran.
(3)Department of Psychiary, Babol University of Medical Sciences, Babol, Iran.
(4)Social Determinants of Health Research Center, Health Research Institute,
Babol University of Medical Sciences, Babol, Iran.
(5)Non-Communicable Pediatric Diseases Research Center, Health Research
Institute, Babol University of Medical Sciences, Babol, Iran.
DOI: 10.22088/cjim.9.1.87
PMCID: PMC5771366
PMID: 29387325
Conflict of interest statement: The authors declare that there are no conflicts
of interest.
Maltezou HC(1), Dedoukou X(1), Asimaki H(2), Kontou I(2), Ioannidou L(2),
Mitromara K(2), Theodoridou K(2), Katerelos P(1), Theodoridou M(2).
Author information:
(1)Department for Interventions in Health-Care Facilities, Hellenic Center for
Disease Control and Prevention, Athens, Greece.
(2)First Department of Pediatrics, University of Athens, "Aghia Sophia"
Children's Hospital, Athens, Greece.
Background: Greece is among the European countries with the highest consumption
of antibiotics.
Objectives: To study the rates and characteristics of consumption of antibiotics
in the community by children in Greece.
Methods: Questionnaire-based study of parents of hospitalized children.
Results: A total of 549 children were studied; 247 (45%) received at least one
course of antibiotics the previous year (mean number of antibiotic courses the
past year: 1.9), including 427 (91.8%) following examination by a pediatrician, 6
(1.3%) following phone consultation, 2 (0.4%) following suggestion by a
pharmacist and 2 (0.4%) as self-medication. Prevalent reasons for antibiotic
consumption were acute otitis media (AOM) (27.3%), pharyngotonsillitiss (25.4%),
and bronchitis (17.8%). Amoxicillin-clavulanate was the prevalent antibiotic for
pharyngotonsillitis, urinary tract infection (UTI) and skin infection (30.5%,
35.7% and 36.4% of cases, respectively), amoxicillin for AOM and pneumonia (32.3%
and 36.4% of cases, respectively), and clarithromycin for bronchitis (27.7%). We
found 84.3%, 81.9%, 64.3%, 63.7%, and 50% of parents reporting treatment
consisted with the national guidelines for AOM, pneumonia, UTI, skin infection,
and pharyngotonsillitis, respectively. In the multivariate analysis, an age of
1-5 years and asthma were significantly associated with a higher probability for
antibiotic consumption.
Conclusions: Antibiotic consumption of children in Greece is mainly driven by
pediatricians. Continuing medical education is expected to further improve
antibiotic prescription practices by pediatricians.
DOI: 10.1016/j.ijpam.2017.04.002
PMCID: PMC6372488
PMID: 30805511
Iwase M(1), Nishimura Y(1), Kurata N(2), Namba H(1), Hirai T(1), Kiuchi Y(1).
Author information:
(1)Department of Pharmacology, Showa University School of Medicine.
(2)Faculty of Arts and Sciences at Fujiyoshida, Showa University.
DOI: 10.1248/bpb.b17-00118
PMID: 28966237 [Indexed for MEDLINE]
The correlation between pain perception among patients with six different
orthodontic archwires and the degree of dental crowding.
Huckvale K(1), Adomaviciute S(2), Prieto JT(3), Leow MK(4)(5)(6), Car J(7)(8).
Author information:
(1)Global eHealth Unit, Imperial College London, Reynolds Building, St Dunstans
Road, London, W6 8RP, UK. c.huckvale@imperial.ac.uk.
(2)Global eHealth Unit, Imperial College London, Reynolds Building, St Dunstans
Road, London, W6 8RP, UK. samanta.adomaviciute@gmail.com.
(3)CRG, École polytechnique, Palaiseau, France.
jose-tomas.prieto@polytechnique.edu.
(4)Department of Endocrinology, Tan Tock Seng Hospital, Singapore, Singapore.
melvin.leow@sics.a-star.edu.org.
(5)Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore,
Singapore. melvin.leow@sics.a-star.edu.org.
(6)Singapore Institute for Clinical Studies, A*STAR, Singapore, Singapore.
melvin.leow@sics.a-star.edu.org.
(7)Global eHealth Unit, Imperial College London, Reynolds Building, St Dunstans
Road, London, W6 8RP, UK. josip.car@imperial.ac.uk.
(8)Health Services and Outcomes Research Programme, LKC Medicine, Imperial
College - Nanyang Technological University, Singapore, Singapore.
josip.car@imperial.ac.uk.
Comment in
BMC Med. 2015;13:205.
BACKGROUND: Medical apps are widely available, increasingly used by patients and
clinicians, and are being actively promoted for use in routine care. However,
there is little systematic evidence exploring possible risks associated with apps
intended for patient use. Because self-medication errors are a recognized source
of avoidable harm, apps that affect medication use, such as dose calculators,
deserve particular scrutiny. We explored the accuracy and clinical suitability of
apps for calculating medication doses, focusing on insulin calculators for
patients with diabetes as a representative use for a prevalent long-term
condition.
METHODS: We performed a systematic assessment of all English-language
rapid/short-acting insulin dose calculators available for iOS and Android.
RESULTS: Searches identified 46 calculators that performed simple mathematical
operations using planned carbohydrate intake and measured blood glucose. While
59% (n = 27/46) of apps included a clinical disclaimer, only 30% (n = 14/46)
documented the calculation formula. 91% (n = 42/46) lacked numeric input
validation, 59% (n = 27/46) allowed calculation when one or more values were
missing, 48% (n = 22/46) used ambiguous terminology, 9% (n = 4/46) did not use
adequate numeric precision and 4% (n = 2/46) did not store parameters faithfully.
67% (n = 31/46) of apps carried a risk of inappropriate output dose
recommendation that either violated basic clinical assumptions (48%, n = 22/46)
or did not match a stated formula (14%, n = 3/21) or correctly update in response
to changing user inputs (37%, n = 17/46). Only one app, for iOS, was issue-free
according to our criteria. No significant differences were observed in issue
prevalence by payment model or platform.
CONCLUSIONS: The majority of insulin dose calculator apps provide no protection
against, and may actively contribute to, incorrect or inappropriate dose
recommendations that put current users at risk of both catastrophic overdose and
more subtle harms resulting from suboptimal glucose control. Healthcare
professionals should exercise substantial caution in recommending unregulated
dose calculators to patients and address app safety as part of self-management
education. The prevalence of errors attributable to incorrect interpretation of
medical principles underlines the importance of clinical input during app design.
Systemic issues affecting the safety and suitability of higher-risk apps may
require coordinated surveillance and action at national and international levels
involving regulators, health agencies and app stores.
DOI: 10.1186/s12916-015-0314-7
PMCID: PMC4433091
PMID: 25943590 [Indexed for MEDLINE]
Author information:
(1)Department of Pharmacology & Therapeutics, College of Health Sciences,
Makerere University, P.O. Box 7072, Kampala, Uganda. ocanmoses@gmail.com.
(2)Department of Medicine, College of Health Sciences, Makerere University, P.O.
Box 7072, Kampala, Uganda.
(3)Department of Pharmacy, College of Health Sciences, Makerere University, P. O.
Box, 7072, Kampala, Uganda.
BACKGROUND: Medicines are commonly accessed and used for management of illness in
children without a prescription. This potentially increases the risk of unwanted
treatment outcomes. We investigated medicine use practices in management of
symptoms of acute upper respiratory tract infections among children (≤12 years)
in households in Nakawa division, Kampala city.
METHODS: This was a cross-sectional study conducted among 390 randomly selected
children. Data on use of medicines in children (≤12 years) during recent episode
of acute upper respiratory tract infection was collected from their care takers
using an interviewer administered questionnaire. A recall period of two weeks
(14 days) was used in during data collection.
RESULTS: The prevalence of giving children non-prescription antimicrobial
medicines was 44.8% (38.3-52.2). The most common disease symptoms that the
children reportedly had included flu, 84.9% (331/390), cough, 83.1% (324/390),
and undefined fever, 69.7% (272/390). Medicines commonly given to children
included, paracetamol 53.1% (207/390), Coartem 29.7% (116/390), cough linctus
20.8% (81/390), amoxicillin 18.9% (74/390), Co-trimoxazole 18.5% (72/390), and
diphenhydramine 15.4% (60/390). The major sources of medicines given to the
children was hospital/clinic, 57.26% (223/390). Most of the children, 81% were
given more than one medicine at a time. The majority, 62.3% (243/390) of the care
takers who gave the children medicine during the recent illness were not aware of
any medicine (s) that should not be given to children. The predictors of
non-prescription use of antimicrobial medicines in managing symptoms of acute
upper respiratory tract infections in children included, medicines obtained from
drug shop (PR: 1.45, CI: 1.14-1.85), medicines at home (PR: 1.8, CI: 0.83-1.198)
and type of medicine (antimalarial) (PR: 2.8, CI: 1.17-6.68).
CONCLUSION: Children are commonly given multiple medicines during episodes of
acute upper respiratory tract infections with most antimicrobial agents accessed
and used without a prescription in Kampala city, Uganda.
DOI: 10.1186/s12889-017-4770-1
PMCID: PMC5609015
PMID: 28934933 [Indexed for MEDLINE]
Author information:
(1)Drs. Carvalho and Evans-Gilbert are with the Department of Pediatrics at the
Cornwall Regional Hospital in Montego Bay, Jamaica.
(2)Dr. Evans-Gilbert is also with the University of the West Indies, Western
Campus, in Montego Bay, Jamaica.
PMCID: PMC6538397
PMID: 31214478
Banger HS(1), Sethi A(1), Malhotra S(2), Malhotra SK(1), Kaur T(1).
Author information:
(1)Department of Skin and STD, Government Medical College, Amritsar, Punjab,
India.
(2)Department of Microbiology, Government Medical College, Amritsar, Punjab,
India.
DOI: 10.4103/0253-7184.203436
PMCID: PMC5389216
PMID: 28442804
527. J Clin Med. 2019 May 10;8(5). pii: E652. doi: 10.3390/jcm8050652.
Author information:
(1)Hannover Medical School, Centre for Pharmacology and Toxicology,
Carl-Neuberg-Str. 1, 30625 Hannover, Germany. nora.anderson@web.de.
(2)Hannover Medical School, Centre for Pharmacology and Toxicology,
Carl-Neuberg-Str. 1, 30625 Hannover, Germany. borlak.juergen@mh-hannover.de.
DOI: 10.3390/jcm8050652
PMCID: PMC6572430
PMID: 31083451
Liddle J(1), Roddy E(1), Mallen CD(1), Hider SL(1), Prinjha S(2), Ziebland S(2),
Richardson JC(1).
Author information:
(1)Research Institute for Primary Care and Health Sciences, Keele University,
Keele, UK.
(2)Nuffield Department of Primary Care Health Sciences, Oxford University,
Oxford, UK.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://group.bmj.com/group/rights-licensing/permissions.
DOI: 10.1136/bmjopen-2015-008323
PMCID: PMC4577947
PMID: 26369796 [Indexed for MEDLINE]
Pain as a risk factor for substance use: a qualitative study of people who use
drugs in British Columbia, Canada.
Voon P(1)(2), Greer AM(2)(3), Amlani A(3), Newman C(3), Burmeister C(3), Buxton
JA(4)(5).
Author information:
(1)British Columbia Centre on Substance Use, 400 - 1045 Howe Street, Vancouver,
BC, V6Z 2A9, Canada.
(2)School of Population and Public Health, Faculty of Medicine, University of
British Columbia, 2206 East Mall, Vancouver, BC, V6Z 1Z3, Canada.
(3)British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver,
BC, V5Z 4R4, Canada.
(4)School of Population and Public Health, Faculty of Medicine, University of
British Columbia, 2206 East Mall, Vancouver, BC, V6Z 1Z3, Canada.
jane.buxton@bccdc.ca.
(5)British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver,
BC, V5Z 4R4, Canada. jane.buxton@bccdc.ca.
DOI: 10.1186/s12954-018-0241-y
PMCID: PMC6034304
PMID: 29976203 [Indexed for MEDLINE]
530. Addict Biol. 2014 Nov;19(6):1020-31. doi: 10.1111/adb.12082. Epub 2013 Aug 6.
Berg SA(1), Sentir AM, Cooley BS, Engleman EA, Chambers RA.
Author information:
(1)Laboratory for Translational Neuroscience of Dual Diagnosis and Development,
Institute of Psychiatric Research and Training Program in Addiction Psychiatry,
Indiana University Department of Psychiatry, Indianapolis, IN, USA.
Nicotine dependence is the leading cause of death in the United States. However,
research on high rates of nicotine use in mental illness has primarily explained
this co-morbidity as reflecting nicotine's therapeutic benefits, especially for
cognitive symptoms, equating smoking with 'self-medication'. We used a leading
neurodevelopmental model of mental illness in rats to prospectively test the
alternative possibility that nicotine dependence pervades mental illness because
nicotine is simply more addictive in mentally ill brains that involve
developmental hippocampal dysfunction. Neonatal ventral hippocampal lesions
(NVHL) have previously been demonstrated to produce post-adolescent-onset,
pharmacological, neurobiological and cognitive-deficit features of schizophrenia.
Here, we show that NVHLs increase adult nicotine self-administration,
potentiating acquisition-intake, total nicotine consumed and drug seeking.
Behavioral sensitization to nicotine in adolescence prior to self-administration
is not accentuated by NVHLs in contrast to increased nicotine self-administration
and behavioral sensitization documented in adult NVHL rats, suggesting
periadolescent neurodevelopmental onset of nicotine addiction vulnerability in
the NVHL model. Delivering a nicotine regimen approximating the exposure used in
the sensitization and self-administration experiments (i.e. as a treatment) to
adult rats did not specifically reverse NVHL-induced
cortical-hippocampal-dependent cognitive deficits and actually worsened cognitive
efficiency after nicotine treatment stopped, generating deficits that resemble
those due to NVHLs. These findings represent the first prospective evidence
demonstrating a causal link between disease processes in schizophrenia and
nicotine addiction. Developmental cortical-temporal limbic dysfunction in mental
illness may thus amplify nicotine's reinforcing effects and addiction risk and
severity, even while producing cognitive deficits that are not specifically or
substantially reversible with nicotine.
© 2013 The Authors. Addiction Biology published by John Wiley & Sons Ltd on
behalf of Society for the Study of Addiction.
DOI: 10.1111/adb.12082
PMCID: PMC3916969
PMID: 23919443 [Indexed for MEDLINE]
The patient with rhinitis in the pharmacy. A cross-sectional study in real life.
Lombardi C(1), Musicco E(1), Rastrelli F(2), Bettoncelli G(3), Passalacqua G(4),
Canonica GW(4).
Author information:
(1)Unit of Allergy-Clinical Immunology & Respiratory Diseases - Department of
Medicine & Geriatrics, Poliambulanza Hospital Institute, Brescia, Italy.
(2)President of the Order of Pharmacists of Brescia, Brescia, Italy.
(3)General Practitioner, Brescia, National Responsible for the Pulmonology Area
of the Italian Society of General Practitioners (SIMMG), Brescia, Italy.
(4)Allergy & Respiratory Diseases, Department of Internal Medicine, University of
Genoa, Genoa, Italy.
DOI: 10.1186/s40733-015-0002-6
PMCID: PMC4970378
PMID: 27965758
Voon P(1), Hayashi K(2), Milloy MJ(3), Nguyen P(2), Wood E(3), Montaner J(3),
Kerr T(4).
Author information:
(1)British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital,
Vancouver, BC, Canada; School of Population and Public Health, Faculty of
Medicine, University of British Columbia, Vancouver, BC, Canada.
(2)British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital,
Vancouver, BC, Canada.
(3)British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital,
Vancouver, BC, Canada; Department of Medicine, University of British Columbia,
St. Paul's Hospital, Vancouver, BC, Canada.
(4)British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital,
Vancouver, BC, Canada; Department of Medicine, University of British Columbia,
St. Paul's Hospital, Vancouver, BC, Canada. Electronic address:
uhri-tk@cfenet.ubc.ca.
The complexity of treating concurrent pain and opioid dependence among many
methadone-maintained individuals presents a major challenge in many clinical
settings. Furthermore, recent expert guidelines have called for increased
research on the safety of methadone in the context of chronic pain. This study
explores the prevalence and correlates of pain among a prospective cohort of
people who use illicit drugs in Vancouver, British Columbia, Canada, who reported
enrollment in methadone maintenance treatment (MMT) between 2011 and 2014. Among
the 823 participants eligible for this analysis, 338 (40.9%) reported moderate
pain and 91 (11.1%) reported extreme pain at the first study visit. In
multivariable, generalized, linear mixed model analyses, higher pain severity was
positively and independently associated with self-managing pain (adjusted odds
ratio [AOR] 2.15, 95% confidence interval [CI] 1.77-2.60), patient perception of
methadone dose being too low (AOR 1.82, 95% CI 1.41-2.34), older age (AOR 1.31,
95% CI 1.13-1.51), having a physical disability (AOR 4.59, 95% CI 3.73-5.64),
having ever been diagnosed with a mental illness (AOR 1.44, 95% CI 1.13-1.84),
white ethnicity (AOR 1.42, 95% CI 1.10-1.83), and marijuana use (AOR 1.25, 95% CI
1.02-1.52). These findings suggest several areas for clinical intervention,
particularly related to patient education and alternative analgesic approaches
for MMT patients experiencing pain. Perspective: To better understand the
complexity of concurrent pain and opioid dependency among individuals on
methadone maintenance treatment, this article describes the prevalence and
correlates of higher pain severity among methadone-maintained people who use
illicit drugs. Patients on methadone with comorbid pain may benefit from
education and alternative analgesic approaches.
Copyright © 2015 American Pain Society. Published by Elsevier Inc. All rights
reserved.
DOI: 10.1016/j.jpain.2015.06.003
PMCID: PMC4556532
PMID: 26101814 [Indexed for MEDLINE]
Khan ID(1), Khan SA(2), Asima B(3), Hussaini SB(4), Zakiuddin M(5), Faisal FA(6).
Author information:
(1)Clinical Microbiology and Infectious Diseases, Army College of Medical
Sciences and Base Hospital, New Delhi 110010, India. Electronic address:
titan_afmc@yahoo.com.
(2)Army College of Medical Sciences and Base Hospital, New Delhi 110010, India.
(3)Nuclear Medicine, Army Hospital Research and Referral, New Delhi, India.
(4)Madurai Medical College, Madurai 625020, India.
(5)Provincial Medical Services, Karnataka, India.
(6)MH, Roorkee, India.
Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.jiph.2017.06.004
PMID: 28668659 [Indexed for MEDLINE]
Author information:
(1)Dr. Shireen Qasim Bham, DCH, FCPS. Department of Pediatrics, Liaquat College
of Medicine & Dentistry and Darul Sehat Hospital, Karachi, Pakistan.
(2)Dr. Farhan Saeed, DCH, FCPS. Department of Pediatrics, Liaquat College of
Medicine & Dentistry and Darul Sehat Hospital, Karachi, Pakistan.
(3)Dr. Manzar Alam Shah, MPH. Department of Community Medicine, Liaquat College
of Medicine & Dentistry and Darul Sehat Hospital, Karachi, Pakistan.
DOI: 10.12669/pjms.326.10788
PMCID: PMC5216320
PMID: 28083064
Conflict of interest statement: Declaration of interest: The authors declare no
conflict of interest with regard to research, authorship and publication of the
study.
Poor medical care for people with migraine in Europe - evidence from the
Eurolight study.
Katsarava Z(1), Mania M(2), Lampl C(3), Herberhold J(4), Steiner TJ(5)(6).
Author information:
(1)Evangelical Hospital Unna, University of Duisburg-Essen, Essen, Germany.
Zaza.katsarava@gmail.com.
(2)Aversi Hospital, Tbilisi, Georgia.
(3)Headache Medical Center, Department of Neurogeriatric Medicine and
Remobilisation, Hospital of the Sisters of Charity, Linz, Austria.
(4)Medical Faculty, Stradins University, Riga, Latvia.
(5)Department of Neuromedicine and Movement Science, Faculty of Medicine and
Health Sciences, NTNU Norwegian University of Science and Technology, Trondheim,
Norway.
(6)Division of Brain Sciences, Imperial College London, London, UK.
DOI: 10.1186/s10194-018-0839-1
PMCID: PMC5794675
PMID: 29392600 [Indexed for MEDLINE]
Cardile S(1), Martinelli M(1), Barabino A(1), Gandullia P(1), Oliva S(1), Di
Nardo G(1), Dall'Oglio L(1), Rea F(1), de'Angelis GL(1), Bizzarri B(1), Guariso
G(1), Masci E(1), Staiano A(1), Miele E(1), Romano C(1).
Author information:
(1)Sabrina Cardile, Claudio Romano, Gastroenterology and Endoscopic Unit,
Department of Pediatrics, University of Messina, 98100 Messina, Italy.
DOI: 10.3748/wjg.v22.i5.1877
PMCID: PMC4724619
PMID: 26855547 [Indexed for MEDLINE]
Santos DN(1), Santos KO(2), Paixão AB(2), Andrade RC(3), Costa DT(4), S-Martin
DL(5), Sá KN(6), Baptista AF(7).
Author information:
(1)Universidade Federal da Bahia, Programa de Pós-graduação em Medicina e Saúde,
Salvador, BA, Brazil; Universidade Federal da Bahia, Laboratório de
Eletroestimulação Funcional, Salvador, BA, Brazil; Universidade Federal da Bahia,
Hospital Professor Edgard Santos, Serviço de Imunologia, Salvador, BA, Brazil.
(2)Universidade Federal da Bahia, Laboratório de Eletroestimulação Funcional,
Salvador, BA, Brazil.
(3)Universidade Federal da Bahia, Hospital Professor Edgard Santos, Serviço de
Imunologia, Salvador, BA, Brazil.
(4)Universidade Federal da Bahia, Hospital Professor Edgard Santos, Serviço de
Imunologia, Salvador, BA, Brazil; Universidade Estadual do Sudoeste da Bahia,
Vitoria da Conquista, BA, Brazil.
(5)Universidade Federal da Bahia, Laboratório de Eletroestimulação Funcional,
Salvador, BA, Brazil; Universidade Federal da Bahia, Faculdade de Medicina da
Bahia, Salvador, BA, Brazil.
(6)Universidade Federal da Bahia, Laboratório de Eletroestimulação Funcional,
Salvador, BA, Brazil; Escola Bahiana de Medicina e Saúde Pública, Pós graduação e
pesquisa, Salvador, BA, Brazil.
(7)Universidade Federal da Bahia, Programa de Pós-graduação em Medicina e Saúde,
Salvador, BA, Brazil; Universidade Federal da Bahia, Laboratório de
Eletroestimulação Funcional, Salvador, BA, Brazil; Escola Bahiana de Medicina e
Saúde Pública, Pós graduação e pesquisa, Salvador, BA, Brazil. Electronic
address: afbaptista@ufba.br.
DOI: 10.1016/j.bjid.2016.11.008
PMID: 28011062 [Indexed for MEDLINE]
Author information:
(1)Pharmacy Department, School of Sciences, Universidad Nacional de Colombia.
Bogotá (Colombia). jaaponteg@unal.edu.co.
(2)Pharmacy Department, School of Sciences, Universidad Nacional de Colombia.
Bogotá (Colombia). anagonzalezac@unal.edu.co.
(3)Pharmacy Department, School of Sciences, Universidad Nacional de Colombia.
Bogotá (Colombia). jjlopezg@unal.edu.co.
(4)Director Public Health and Health Sciences Research Institute, University of
California. Merced, CA (United States). pbrown3@ucmerced.edu.
(5)Hospital Universitario Nacional de Colombia; & Clinical Research Institute,
Faculty of Medicine, Universidad Nacional de Colombia. Bogotá (Colombia).
jheslavas@unal.edu.co.
DOI: 10.18549/PharmPract.2019.1.1394
PMCID: PMC6463418
PMID: 31015877
Conflict of interest statement: CONFLICT OF INTEREST The authors state that they
do not present any conflict of interests in the present investigation.
Author information:
(1)Department of Otorhinolaryngology, College of Medicine, University of Ibadan,
Ibadan and University College Hospital, Ibadan Nigeria.
DOI: 10.11604/pamj.2017.26.177.11519
PMCID: PMC5483367
PMID: 28674570 [Indexed for MEDLINE]
Author information:
(1)Intensive Care Unit, Department of Anesthesiology and Intensive Care, Erzurum
Regional Training and Research Hospital, Erzurum, Turkey.
(2)Department of Psychology, Norwegian University of Science and Technology
(NTNU), Trondheim, Norway. Electronic address: timo.lajunen@svt.ntnu.no.
(3)Department of Economics, Middle East Technical University, Ankara, Turkey.
Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.jiph.2016.11.011
PMID: 28209467 [Indexed for MEDLINE]
Author information:
(1)Department of Pathology, R.D. Gardi Medical College, Ujjain, India.
(2)Central Clinical Laboratory, Ujjain Charitable Trust Hospital and Research
Centre, Ujjain, India.
(3)Division of Global Health, Department of Public Health Sciences, Karolinska
Institutet, Stockholm, Sweden.
(4)Centre for International Health, Department of Global Public Health and
Primary Care, University of Bergen, Norway.
(5)Intern, R.D. Gardi Medical College, Ujjain, India.
(6)Department of Thoracic Medicine, Haukeland University Hospital, Bergen,
Norway.
DOI: 10.1155/2019/4840561
PMCID: PMC6378024
PMID: 30854235
Boumil EF(1)(2), Vohnoutka RB(1)(2), Liu Y(2), Lee S(1), Shea TB(1).
Author information:
(1)Laboratory for Neuroscience, University of Massachusetts Lowell, Lowell, MA
01854, USA.
(2)Department of Biomedical and Nutritional Sciences, University of Massachusetts
Lowell, Lowell, MA 01854, USA.
DOI: 10.2174/1874205X01711010084
PMCID: PMC5748836
PMID: 29387280
543. Int J Environ Res Public Health. 2016 Dec 22;14(1). pii: E7. doi:
10.3390/ijerph14010007.
Motivations and Limitations Associated with Vaping among People with Mental
Illness: A Qualitative Analysis of Reddit Discussions.
Sharma R(1), Wigginton B(2), Meurk C(3)(4), Ford P(5), Gartner CE(6).
Author information:
(1)School of Public Health, The University of Queensland, Herston, QLD 4006,
Australia. r.ratika@uq.edu.au.
(2)School of Public Health, The University of Queensland, Herston, QLD 4006,
Australia. b.wigginton@uq.edu.au.
(3)School of Public Health, The University of Queensland, Herston, QLD 4006,
Australia. c.meurk@uq.edu.au.
(4)Policy and Epidemiology Group, Queensland Centre for Mental Health Research,
Locked Bag 500, Archerfield, QLD 4018, Australia. c.meurk@uq.edu.au.
(5)School of Dentistry, The University of Queensland, Herston, QLD 4006,
Australia. p.ford1@uq.edu.au.
(6)School of Public Health, The University of Queensland, Herston, QLD 4006,
Australia. c.gartner@uq.edu.au.
This study aims to understand the nature and significance of online lay
discussions about e-cigarettes and mental illness. We systematically searched the
website Reddit.com using keywords related to e-cigarettes and mental illness. We
coded relevant posts into themes under the framework of motivations for and
limitations of vaping for people with mental illness. The thematic analysis
included 3263 comments from 133 discussion threads. Six themes were classified as
motivations to vape for people with mental illness: Self-medication; Quitting
smoking; Freedom and control; Hobby; Social connectedness; and Motivation from
caregivers and online communities. The limitations of vaping included:
Unsatisfactory substitute for cigarettes and psychiatric medicines; Drug
interactions; Nicotine addiction; Risks of e-liquid; Practical difficulties and
Cost. People with mental illness; and their carers; use online discussion boards
like Reddit to discuss the benefits and limitations of e-cigarettes for people
with mental illness. Both positive and negative views exist. Media platforms like
Reddit may shape the opinions of stakeholders and generate lay expertise about
contentious health topics such as e-cigarettes. These findings have implications
for policy and practice concerning assisting smokers with mental illness to
reduce their health risk through switching to e-cigarettes.
DOI: 10.3390/ijerph14010007
PMCID: PMC5295258
PMID: 28025516 [Indexed for MEDLINE]
Larsson M(1), Odberg Pettersson K(1), Kashiha J(2), Ross MW(3), Agardh A(1).
Author information:
(1)Division of Social Medicine and Global Health, Department of Clinical Sciences
Malmö, Lund University, Malmö, Sweden.
(2)Community Health Education Services & Advocacy (CHESA), Dar es Salaam,
Tanzania.
(3)Programme in Human Sexuality, Department of Family Medicine and Community
Health, Medical School, University of Minnesota, Minneapolis, Minnesota, United
States of America.
DOI: 10.1371/journal.pone.0166019
PMCID: PMC5094583
PMID: 27812206 [Indexed for MEDLINE]
Author information:
(1)Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Área de
Psiquiatría, Universidad de Oviedo.. alsusana@uniovi.es.
People with schizophrenia constitute a substantial part of the people who still
smoke. Regarding cognitive performance, the self-medication hypothesis states
that patients smoke to improve their cognitive deficits based on the stimulating
effects of nicotine. The aim of this paper is to describe in detail the
methodology used in the COGNICO study. A quasi-experimental, observational,
prospective, multicenter study with follow-ups over 18 months was conducted in
three cities in northern Spain (Oviedo, Ourense and Santiago de Compostela). A
total of 81 outpatient smokers with schizophrenia were recruited with a mean age
43.35 years (SD = 8.83), 72.8% of them male. They were assigned to 3 groups: a)
control group (smokers); b) patients who quit smoking using nicotine patches; c)
patients who quit smoking with Varenicline. The MATRICS neuropsychological
battery was applied as a primary measure. In addition, a comprehensive assessment
of patients was performed, including the number of cigarettes per day, physical
and psychological dependence on nicotine and CO expired. Clinical evaluation
(PANSS, HDRS, CGI, C-SSRS), anthropometric measurements and vital signs
assessment was also performed. The aim is to identify the relationship between
the pattern of tobacco use and cognitive performance by comparing scores on the
neuropsychological battery MATRICS during the follow-up periods (3, 6, 12 and
18months). The importance of this study lies in addressing a topical issue often
ignored by clinicians: the unacceptably high rates of tobacco use in patients
with severe mental disorders.
Publisher: Las personas con esquizofrenia constituyen una parte sustancial de las
personas que todavía fuman. La hipótesis de la automedicación en relación al
rendimiento cognitivo mantiene que los pacientes fuman para mejorar su déficit
cognitivo basándose en los efectos estimulantes de la nicotina. El objetivo de
este artículo es describir la metodología del estudio COGNICO. Estudio
cuasiexperimental, observacional, prospectivo, multicéntrico y con seguimiento a
3, 6, 12 y 18 meses. Fue llevado a cabo en tres ciudades del norte de España
(Oviedo, Ourense y Santiago de Compostela). Se reclutaron 81pacientes con
esquizofrenia fumadores (edad media de 43,35 años (DT=8,83). 72,8% varones). Se
asignaron a 3 grupos: a) control: pacientes fumadores; b) pacientes que dejan de
fumar mediante parches de nicotina; c) pacientes que dejan de fumar mediante
vareniclina. Como medida primaria se aplicó la batería neuropsicológica MATRICS.
Además, se llevó a cabo una evaluación comprehensiva de los pacientes, que
incluía el número de cigarrillos por día, la dependencia física y psicológica a
la nicotina y el CO expirado. También se realizó una evaluación clínica general
(PANSS, HDRS, ICG, C-SSRS) así como un seguimiento de las medidas antropométricas
y los signos vitales. Se pretende identificar la relación entre el patrón de
consumo de tabaco y el rendimiento cognitivo mediante la comparación de las
puntuaciones en la batería neuropsicológica MATRICS durante los períodos de
seguimiento.
DOI: 10.20882/adicciones.724
PMID: 27391843 [Indexed for MEDLINE]
Müller M(1), Rodgers S(2), Rössler W(3), Castelao E(4), Preisig M(4),
Ajdacic-Gross V(2), Vandeleur C(4).
Author information:
(1)Department of Psychiatry, Psychotherapy and Psychosomatics, Zurich University
Hospital of Psychiatry, Zurich, Switzerland. Electronic address:
mario.mueller@dgsp.uzh.ch.
(2)Department of Psychiatry, Psychotherapy and Psychosomatics, Zurich University
Hospital of Psychiatry, Zurich, Switzerland.
(3)Department of Psychiatry, Psychotherapy and Psychosomatics, Zurich University
Hospital of Psychiatry, Zurich, Switzerland; Collegium Helveticum, University of
Zurich and Swiss Federal Institute of Technology, Zurich, Switzerland; Institute
of Psychiatry, Laboratory of Neuroscience (LIM 27), University of Sao Paulo, Sao
Paulo, Brazil.
(4)Department of Psychiatry, University Hospital of Lausanne, Lausanne,
Switzerland.
OBJECTIVE: The aim of the study was to compare subjects dually diagnosed with
posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) to those with
only one or none of these conditions regarding helpseeking needs and behaviors.
METHOD: Data from a large community sample (N=3694) were used to assess the
associations among lifetime PTSD and AUD, other psychiatric disorders, clinical
characteristics and lifetime helpseeking behaviors derived from a semi-structured
interview.
RESULTS: Comorbid individuals had more severe clinical profiles and were more
impaired than individuals with either PTSD or AUD alone or those with no/other
psychiatric conditions. However, they did not differ in overall helpseeking
behavior from any other group. Those with comorbid PTSD/AUD were even less likely
than the other groups to seek help for depression and anxiety disorders through
specific treatment facilities or the use of prescribed psychotropic drugs.
CONCLUSIONS: Despite a greater need for treatment the comorbid group did not seek
more help than the others. Their lower use of prescribed drugs supports the
self-medication hypothesis, suggesting that those individuals relieve their
symptoms through higher alcohol use instead. Our findings underline the need for
health care facilities to encourage helpseeking behavior in the aftermath of
stressful life events.
DOI: 10.1016/j.comppsych.2015.07.013
PMID: 26343486 [Indexed for MEDLINE]
Mahmoud A(1), Messaoud R(1), Abid F(1), Ksiaa I(2), Bouzayene M(1), Khairallah
M(3).
Author information:
(1)Department of Ophthalmology, Taher Sfar University Hospital, Faculty of
Medicine, University of Monastir, Monastir, Tunisia.
(2)Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty
of Medicine, University of Monastir, 5019, Monastir, Tunisia.
(3)Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty
of Medicine, University of Monastir, 5019, Monastir, Tunisia.
moncef.khairallah@rns.tn.
BACKGROUND: The purpose of this single case report was to report the use of
anterior segment optical coherence tomography for the diagnosis and management of
a retained vegetal intraocular foreign body.
RESULTS: A 23-year-old otherwise healthy male presented with a progressive vision
loss in the right eye (RE). He reported a mild ocular trauma with a tree leaf
1 year ago followed by recurrent episodes of redness and pain in the RE that
partially resolved after a self-medication with topical steroids. Visual acuity
of the RE was limited to light perception. Slit-lamp examination of the RE showed
an iris granuloma with overlying exudate and associated anterior chamber
inflammatory reaction. Film X-rays, contact B-scan ultrasonography, and CT scan
showed no abnormalities. Anterior segment optical coherence tomography revealed
an enclaved iris foreign body. The foreign body was removed after a short course
of local antibio-corticosteroid therapy. This was followed 2 months later by
cataract surgery with intraocular lens implantation, with subsequent improvement
of visual acuity to 20/40.
CONCLUSIONS: A missed intraocular foreign body can lead to sight-threatening
complications. Anterior segment optical coherence tomography may be useful for
detecting non-clinically evident intraocular foreign body involving the anterior
segment masquerading as chronic anterior uveitis.
DOI: 10.1186/s12348-017-0130-7
PMCID: PMC5442073
PMID: 28536985
Author information:
(1)Chemical Engineering and Biotechnology, University of Cambridge, CB2 3RA (UK).
© 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an
open access article under the terms of the Creative Commons Attribution License,
which permits use, distribution and reproduction in any medium, provided the
original work is properly cited.
DOI: 10.1002/cmdc.201402285
PMCID: PMC4506560
PMID: 25209896 [Indexed for MEDLINE]
Author information:
(1)Department of Medical Laboratory Technology, Kwame Nkrumah University of
Science and Technology, Kumasi, Ghana.
(2)Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah
University of Science and Technology, Kumasi, Ghana.
There has been a significant rise in global antibiotic use in recent years.
Development of resistance has been linked to easy accessibility, lack of
regulation of sale, increased tendency to self-medicate and the lack of public
knowledge. The increase in antibiotic misuse, including self-medication, has not
been well documented in developing countries. Antibiotic use prior to visiting
health facilities has been found to be prevalent in developing countries. It has
been identified by some studies to increase the likelihood of missed diagnoses
and influence the outcome of bacteriological tests. This study is aimed at
determining the prevalence of prior antibiotic use through a cross-sectional
survey of patients undergoing laboratory tests at two health facilities in Ghana.
Face-to-face questionnaires were used to interview 261 individuals chosen by
random sampling of patients visiting the bacteriology laboratory of the hospitals
within a two-month period. The questionnaire investigated participant demographic
characteristics, knowledge about antibiotics and the nature of antibiotic use.
Antibiotic property detection bioassay was performed on patient's urine sample
using a disk diffusion method to accurately determine antibiotic use within 72
hours. Culture results were used as an index to evaluate the effect of prior
antibiotic use on bacteriological tests. Out of a 261 participants enrolled,
19.9% (95% CI, 14.9-24.9) acknowledged using antibiotics prior to their visit to
the laboratory during the study period. On the contrary, 31.4% (95% CI,
25.7-37.5) of participants' urine samples were positive for antimicrobial
activity. Participants within the age ranges of 20-30, 31-40 and 41-50 years had
significantly lower odds of urine antimicrobial activity. Participants who had
urine antimicrobial activity were more likely to have no growth on their culture
plates than participants who had no urine antimicrobial activity [OR
2.39(1.37-4.18), p = 0.002]. The most commonly used antibiotics were the
penicillins, fluoroquinolones and metronidazole. Although, majority of the
participant (54.8%) had knowledge of antibiotics, most of them had inadequate
information on their proper use. The commonest indications for antibiotic use
were aches and pains (30.3%), diarrhoea (43.3%) and urinary tract infections
(28.0%). Prior antibiotic use was found to increase the likelihood of obtaining a
culture negative result and can affect the outcome of bacteriological tests.
DOI: 10.1371/journal.pone.0210716
PMCID: PMC6333348
PMID: 30645626
Author information:
(1)Department of Public Health, Mizan Tepi University, Mizan Teferi, SNNPR,
Ethiopia.
(2)Department of Epidemiology, Jimma University, Jimma, Oromiya, Ethiopia.
(3)Discipline of Public Health, Faculty of Medicine, Nursing and Health Sciences,
Flinders University, Adelaide, South Australia, Australia.
DOI: 10.1371/journal.pone.0161014
PMCID: PMC5023186
PMID: 27626804 [Indexed for MEDLINE]
Author information:
(1)Division of Social and Administrative Sciences, School of Pharmacy, University
of Wisconsin-Madison, Madison, WI, USA.
(2)Department of Family Medicine and Community Health, University of
Wisconsin-Madison, Madison, WI, USA.
DOI: 10.2147/PPA.S153312
PMCID: PMC5953319
PMID: 29785094
Al-Balbeesi HO(1), Bin Huraib SM(1), AlNahas NW(2), AlKawari HM(1), Abu-Amara
AB(3), Vellappally S(4), Anil S(5).
Author information:
(1)Department of Pediatric Dentistry and Orthodontics, College of Dentistry, King
Saud University, Riyadh, Saudi Arabia.
(2)Department of Periodontics and Community Dentistry, College of Dentistry, King
Saud University, Riyadh, Saudi Arabia.
(3)College of Medicine, Al Imam Mohammed Bin Saud Islamic University, Riyadh,
Saudi Arabia.
(4)Department of Dental Health, College of Applied Medical Sciences, King Saud
University, Riyadh, Saudi Arabia.
(5)Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam
Bin Abdulaziz University, Al Kharj, Saudi Arabia.
DOI: 10.4103/2231-0762.195519
PMCID: PMC5184389
PMID: 28032047
Chukwuocha UM(1), Iwuoha GN(1), Nwakwuo GC(2), Egbe PK(1), Ezeihekaibe CD(3),
Ekiyor CP(1)(2), Dozie INS(1), Burrowes S(3).
Author information:
(1)Department of Public Health, Federal University of Technology, Owerri,
Nigeria.
(2)RAHI Medical Outreach, Port Harcourt, Nigeria.
(3)College of Education and Health Sciences, Touro University, California, United
States of America.
This study assesses malaria prevention and treatment behaviour among people
living with HIV/AIDS (PLWHA) in Owerri, South Eastern Nigeria. Although Nigeria
bears one of the world's largest burdens of both malaria and HIV, there is almost
no research studying how co-infected patients manage their care. We
systematically sampled 398 PLWHA receiving care at Imo State Specialist Hospital
and the Federal Medical Centre in Owerri to complete a structured, pre-tested
questionnaire on malaria care-seeking behaviour. Descriptive statistics were
reported and chi-square tests and multivariate logistic regressions were also
used. The majority of HIV-infected patients (78.9%) reported having had an
episode of suspected malaria quarterly or more often. There was a large variation
in care-seeking patterns: on suspicion of malaria, 29.1% of participants engaged
in self-medication; 39.2% went to drug shops, and only 22.6% visited HIV/AIDS
care centres. Almost 40% waited more than 24 hours before initiating treatment.
Most (60.3%), reported taking recommended artemisinin-based combination
treatments (ACT) but a significant minority took only paracetamol (25.6%) or
herbal remedies (3.5%). Most (80%) finished their chosen course of treatment; and
completion of treatment was significantly associated with the frequency of
suspected malaria occurrence (p = 0.03). Most (62.8%) did not take anti-malaria
medication while taking antiretroviral treatment (ART) and almost all (87.6%)
reported taking an ACT regimen that could potentially interact with Nigeria's
first-line ART regimen. Our findings suggest the need to pay more attention to
malaria prevention and control as a crucial element in HIV/AIDS management in
this part of Nigeria and other areas where malaria and HIV/AIDS are co-endemic.
Also, more research on ART-ACT interactions, better outreach to community-level
drug shops and other private sector stakeholders, and clearer guidelines for
clinicians and patients on preventing and managing co-infection may be needed.
This will require improved collaboration between programmes for both diseases.
DOI: 10.1371/journal.pone.0213742
PMCID: PMC6508638
PMID: 31071091
Home treatment and use of informal market of pharmaceutical drugs for the
management of paediatric malaria in Cotonou, Benin.
Author information:
(1)Institut de recherche pour le développement, Unité mixte de recherche 216:
Mères et enfants face aux infections tropicales, Université Paris-Descartes, 4
Avenue de l'Observatoire, 75006, Paris, France. eapetoh@gmail.com.
(2)Ecole doctorale Pierre Louis de santé publique, ED 393 Epidémiologie et
Sciences de l'Information Biomédicale, Paris, France. eapetoh@gmail.com.
(3)Institut de recherche pour le développement, Unité mixte de recherche 216:
Mères et enfants face aux infections tropicales, Université Paris-Descartes, 4
Avenue de l'Observatoire, 75006, Paris, France.
(4)Centre Norbert Elias EHESS-Campus Marseille La Vieille Charité, 2 Rue de la
Charité, 13002, Marseille, France.
DOI: 10.1186/s12936-018-2504-1
PMCID: PMC6180418
PMID: 30305107 [Indexed for MEDLINE]
Hassali MA(1), Arief M(2), Saleem F(3), Khan MU(4), Ahmad A(5), Mariam W(6),
Bheemavarapu H(7), Syed IA(8).
Author information:
(1)Discipline of Social and Administrative Pharmacy, School of Pharmaceutical
Sciences, Universiti Sains Malaysia. Penang (Malaysia). azmihassali@gmail.com.
(2)Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, UCSI
University. Kuala Lumpur (Malaysia). mohammad.arief786@gmail.com.
(3)Department of Pharmacy Practice, Faculty of Pharmacy & Health Sciences,
University of Balochistan. Quetta (Pakistan). fahaduob@gmail.com.
(4)Faculty of pharmacy, University of Sydney, Sydney, NSW (Australia).
umair104@yahoo.com.
(5)Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, UCSI
University. Kuala Lumpur (Malaysia). akrampharma67@gmail.com.
(6)Department of Community Medicine, Maulana Azad Medical College. New Delhi
(India). warishamariam@gmail.com.
(7)Department of Pharmaceutical Analysis, Talla Padmavati College of Pharmacy.
Warangal (India). hariikabhimavarapu@gmail.com.
(8)Department of Pharmacy, Ibn Sina College of pharmacy. Jeddah (Saudi Arabia).
iizharahmedsyed@gmail.com.
OBJECTIVE: The present study was aimed to evaluate the practices and attitudes of
young Malaysian adults towards the use of antibiotics, and to determine the
socioeconomic factors associated with the antibiotic use.
METHODS: A survey was carried in Cheras community by approaching a conveniently
selected sample of 480 participants. A pre-tested questionnaire was used for data
collection.
RESULT: Of 480 participants approached, 400 agreed to participate in this study,
giving a response rate of 83.3%. The study results showed that 42.75% of the
participants exhibited poor attitudes towards antibiotic usage. Chinese race and
high income were significantly associated with the positive attitudes towards
antibiotic usage. It is shown that the practice of the participants towards
antibiotics was relatively poor. The majority of participants agreed that they do
not consult a doctor for minor illnesses (64%). The main reason for not
consulting a doctor was the high fees of consultation (34.25%) and the
inconvenience of visit (29.25%). However, a large proportion of respondents
(77.5%) agreed that there is a need to enhance antibiotic education among public.
CONCLUSION: The study results identified some crucial gaps in the attitudes and
practices of Cheras community about the use of antibiotics. Thus, improving the
public knowledge and changing their attitude towards antibiotic use along with
proper interventions to regulate the ease of their availability would play a
significant role for the effective use of antibiotics in the community.
DOI: 10.18549/PharmPract.2017.02.929
PMCID: PMC5499350
PMID: 28690695
Author information:
(1)Oncology and Radiotherapy Institute, Nuclear Medicine, Islamabad, Pakistan.
frohpl@gmail.com.
Only few epidemiological studies have examined the rate of active H. pylori
infection in the symptomatic population in Pakistan. This retrospective study
presents the laboratory data collected during the past 13 years (2002 to 2015)
from 2315 symptomatic patients referred to the BreathMAT Lab, Nuclear Medicine,
Oncology and Radiotherapy Institute, Islamabad for the diagnosis of active H.
pylori infection using the 13C Urea Breath Test. Rate of infection and its
association with gender and age were evaluated. The overall rate of active H.
pylori infection was 49.5% and there was no association of this rate of infection
with gender. An increase in rate of infection was observed with increasing age
with significant difference (p < 0.05). The patients that tested negative for
this infection might be having symptoms due to stress and indiscriminate use of
non-steroidal antiinflammatory drugs (NSAIDs) in this community. The fact that
half of the symptomatic patients were negative needs to be highlighted and
further suggests that symptomatic patients should be tested by the 13C UBT before
prescribing antibiotic treatment for H. pylori eradication. In addition, there is
a need to educate this community about the harmful and side effects of self
medication and overuse of NSAIDs.
Author information:
(1)School of Nursing, Beijing University of Chinese Medicine (BUCM), Beijing,
China.
DOI: 10.1016/j.ijnss.2018.09.009
PMCID: PMC6626269
PMID: 31406847
Author information:
(1)Department of Family Medicine, McMaster University, Hamilton, ON, Canada,
lamarche@mcmaster.ca.
DOI: 10.2147/PPA.S165749
PMCID: PMC6056165
PMID: 30050290
Author information:
(1)University of North Carolina at Chapel Hill, School of Nursing, Chapel Hill,
NC 27599, USA. Electronic address: jiarongw@email.unc.edu.
(2)University of Ulsan, College of Medicine, Department of Nursing, Ulsan, South
Korea.
(3)University of Kentucky, College of Nursing, Lexington, KY 40536, USA.
DOI: 10.1016/j.hrtlng.2015.03.006
PMCID: PMC4470745
PMID: 25979573 [Indexed for MEDLINE]
560. BMJ Open. 2019 Jun 5;9(6):e027687. doi: 10.1136/bmjopen-2018-027687.
Xia R(1), Hu X(#)(2), Willcox M(#)(2), Li X(3), Li Y(4), Wang J(5), Li X(1),
Moore M(2), Liu J(1), Fei Y(1).
Author information:
(1)Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese
Medicine, Beijing, China.
(2)Primary Care and Population Sciences, University of Southampton, Southampton,
UK.
(3)Department of International Liaison, World Federation of Chinese Medicine
Societies, Beijing, China.
(4)Department of endocrinology, South of Guang'anmen Hospital, China Academy of
Chinese Medical Sciences, Beijing, China.
(5)Department of Neurology, The Affiliated Hospital of Changchun University of
Chinese Medicine, Changchun, China.
(#)Contributed equally
DOI: 10.1136/bmjopen-2018-027687
PMCID: PMC6561603
PMID: 31171552
Author information:
(1)Department of Psychiatry and Human Behavior, Alpert Medical School of Brown
University, Box G-BH, Providence, RI, 02912, USA. Judelysse_gomez@brown.edu.
(2)Department of Psychiatry and Human Behavior, Alpert Medical School of Brown
University, Box G-BH, Providence, RI, 02912, USA.
(3)Department of Behavioral and Social Sciences, Center for Alcohol and Addiction
Studies, Brown University, Box G-S121-5, Providence, RI, 02912, USA.
(4)Simmons School of Social Work, Boston Children's Hospital, Harvard Medical
School, 300 The Fenway, Boston, MA, 02115, USA.
DOI: 10.1007/s10597-015-9894-0
PMCID: PMC4565743
PMID: 26017474 [Indexed for MEDLINE]
562. Rev Bras Epidemiol. 2019 Feb 4;21Suppl 02(Suppl 02):e180006. doi:
10.1590/1980-549720180006.supl.2.
Survival of the elderly and exposition to polypharmacy in the city of São Paulo,
Brazil: SABE Study.
Author information:
(1)Departamento de Prática de Saúde Pública, Faculdade de Saúde Pública,
Universidade de São Paulo - São Paulo (SP), Brasil.
(2)Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São
Paulo - São Paulo (SP), Brasil.
(3)Departamento de Enfermagem Médico-Cirúrgica, Escola de Enfermagem,
Universidade de São Paulo - São Paulo (SP), Brasil.
563. Medicines (Basel). 2017 Dec 12;4(4). pii: E90. doi: 10.3390/medicines4040090.
Author information:
(1)Department of Biochemistry, University of Calabar, P.M.B 1115, Calabar 540
Nigeria. eneji.egbung@unical.edu.ng.
(2)Department of Biochemistry, University of Calabar, P.M.B 1115, Calabar 540
Nigeria. dratangwho@gmail.com.
(3)Department of Biochemistry, University of Calabar, P.M.B 1115, Calabar 540
Nigeria. diianer12@yahoo.com.
(4)Department of Biochemistry, University of Calabar, P.M.B 1115, Calabar 540
Nigeria. ndiodimmavictor@gmail.com.
DOI: 10.3390/medicines4040090
PMCID: PMC5750614
PMID: 29231843
Preparing towards Preventing and Containing an Ebola Virus Disease Outbreak: What
Socio-cultural Practices May Affect Containment Efforts in Ghana?
Adongo PB(1), Tabong PT(1), Asampong E(1), Ansong J(2), Robalo M(2), Adanu RM(3).
Author information:
(1)Department of Social and Behavioural Sciences, School of Public Health,
University of Ghana, Legon, Accra, Ghana.
(2)World Health Organization Country Office for Ghana, Accra, Ghana.
(3)Department of Population, Family and Reproductive Health, School of Public
Health, University of Ghana, Legon, Accra, Ghana.
BACKGROUND: Ebola Virus Disease (EVD) is a condition with high fatality. Though
the disease is deadly, taking precautions to reduce contact with infected people
and their secretions can prevent cross- infection. In the 2014 EVD outbreak,
socio-cultural factors were identified to be responsible for the spread of the
disease in the three most affected countries in West Africa. In this light, we
undertook this study to identify socio-cultural factors that may influence the
prevention and containment of EVD in Ghana and ways to address such practices.
METHODS: We conducted a descriptive qualitative study in five regions in Ghana.
Twenty-five focus group discussions (5 in each region) with community members (4
in each region) and nurses (1 in each region) were conducted. In addition, forty
(40) in-depth interviews were conducted with various stakeholders and opinion
leaders; eight in each region. All interviews were recorded using a digital voice
recorder and transcribed. With the aid of Nvivo 10 for windows, we analyzed the
data using framework analysis.
RESULTS: We found that socio-cultural practices, such as care of the body of dead
and burial practices, widowhood rites and anointing children with water used to
rinse the dead, were common. These practices require individuals coming into
direct contact with either the dead or items used to take care of the dead.
Social norms also require frequent handshakes in all social gatherings such as
funeral, and religious congregations. We also found that self-medication (using
herbs and orthodox medications) was a common practice. People use both biomedical
and non-orthodox health outlets either simultaneously or in sequence in times of
ill-health.
CONCLUSION: The study concludes that high risk socio-cultural practices were
common among Ghanaians and generally perceived as indispensable. These high risk
practices may hinder containment efforts in the event of an outbreak. Community
leaders should be engaged in any social mobilization to modify these practices as
part of preparation efforts.
DOI: 10.1371/journal.pntd.0004852
PMCID: PMC4948768
PMID: 27428069 [Indexed for MEDLINE]
Author information:
(1)Life and Health Sciences Research Institute (ICVS), School of Health Sciences,
University of Minho, Campus de GualtarBraga, Portugal.
(2)ICVS/3B's, PT Government Associate LaboratoryGuimarães, Portugal.
(3)Department of Pharmacology, Medical School, National and Kapodistrian
University of AthensAthens, Greece.
(4)First Department of Psychiatry, Medical School, National and Kapodistrian
University of AthensAthens, Greece.
DOI: 10.3389/fnbeh.2017.00145
PMCID: PMC5550717
PMID: 28848409
566. Reprod Health. 2016 Jun 8;13 Suppl 1:36. doi: 10.1186/s12978-016-0136-x.
Khowaja AR(1)(2), Qureshi RN(3), Sheikh S(1), Zaidi S(1), Salam R(1), Sawchuck
D(2), Vidler M(2), von Dadelszen P(2), Bhutta Z(1).
Author information:
(1)Division of Women and Child Health, Aga Khan University, Karachi, Pakistan.
(2)Department of Obstetrics and Gynecology, Child and Family Research Institute,
University of British Columbia, Vancouver, Canada.
(3)Division of Women and Child Health, Aga Khan University, Karachi, Pakistan.
rahat.qureshi@aku.edu.
DOI: 10.1186/s12978-016-0136-x
PMCID: PMC4943481
PMID: 27357953 [Indexed for MEDLINE]
567. J Clin Hypertens (Greenwich). 2016 May;18(5):408-14. doi: 10.1111/jch.12781.
Epub
2016 Jan 20.
Kaze FF(1)(2), Kengne AP(3), Magatsing CT(4), Halle MP(5), Yiagnigni E(6), Ngu
KB(2).
Author information:
(1)Department of Medicine and Specialties, Faculty of Medicine and Biomedical
Sciences, The University of Yaoundé 1, Yaoundé, Cameroon.
(2)Department of Internal Medicine, The Yaoundé University Teaching Hospital,
Yaoundé, Cameroon.
(3)South African Medical Research Council, University of Cape Town, Cape Town,
South Africa.
(4)Higher Institute of Health Sciences, Bangangté, Cameroon.
(5)Department of Clinical Sciences, Faculty of Medicine and Pharmaceutical
Sciences, The University of Douala, Douala, Cameroon.
(6)Department of Internal Medicine, Yaoundé Central Hospital, Yaoundé, Cameroon.
Comment in
J Clin Hypertens (Greenwich). 2016 May;18(5):405-7.
Hypertension is a risk factor for renal diseases, which, in turn, are precursors
of hypertension. The authors assessed the prevalence and determinants of chronic
kidney disease (CKD) among 336 hypertensive adult Cameroonians (mean age,
60.9±11.3 years; 63.4% women) at Yaoundé. Any participant with an estimated
glomerular filtration rate <60 mL/min/1.73 m(2) regardless of the equation used
(Cockcroft-Gault [CG], Modification of Diet in Renal Disease [MDRD], and Chronic
Kidney Disease Epidemiology Collaboration [CKD-EPI]) and/or dipstick proteinuria
was reviewed 3 months later. Participants presented a high prevalence of diabetes
(18.5%), dyslipidemia (17.6%), gout/hyperuricemia (10.7%), overweight/obesity
(68.8%), self-medication (37.5%), and alcohol consumption (33.3%). Hypertension
was uncontrolled in 265 patients (78.9%). The prevalence of CKD was 49.7%, 50.0%,
and 52.1% according to MDRD, CKD-EPI, and CG equations, respectively. Advanced
age, adiposity, and severity of hypertension were determinants of CKD. Nearly
half of the hypertensive patients had CKD regardless of the estimators used,
predicted by well-known risk factors.
DOI: 10.1111/jch.12781
PMID: 26791352 [Indexed for MEDLINE]
568. Psychol Addict Behav. 2014 Dec;28(4):1013-25. doi: 10.1037/a0037257. Epub 2014
Aug 18.
Gaher RM(1), Simons JS(1), Hahn AM(1), Hofman NL(1), Hansen J(1), Buchkoski J(2).
Author information:
(1)Department of Psychology, University of South Dakota.
(2)Sioux Falls Veterans Administration Health Care System.
DOI: 10.1037/a0037257
PMCID: PMC4274209
PMID: 25134021 [Indexed for MEDLINE]
569. WHO South East Asia J Public Health. 2018 Sep;7(2):73-78. doi:
10.4103/2224-3151.239417.
Author information:
(1)International Health Policy Program, Ministry of Public Health, Nonthaburi,
Thailand.
(2)World Health Organization Regional Office for South-East Asia, New Delhi,
India.
The 2015 Global action plan on antimicrobial resistance (GAP-AMR) highlights the
key importance of improving awareness and understanding of antimicrobial
resistance among consumers. While low levels of awareness are not exclusive to
consumers in low- and middle-income countries, the challenges to improving
understanding are compounded in these settings, by factors such as higher rates
of antibiotic self-medication and availability through informal suppliers. In
2016, Thailand set an ambitious target to increase, by 2021, public knowledge of
antibiotic resistance and awareness of appropriate use of antibiotic by 20%. This
involved first establishing baseline data by incorporating a module on antibiotic
awareness into the 2017 national Health and Welfare Survey conducted by the
National Statistical Office. The benefit of this approach is that the data from
the antibiotic module are collected in parallel with data on socioeconomic,
demographic and geospatial parameters that can inform targeted public
communications. The module was developed by review of existing tools that have
been used to measure public awareness of antibiotics, namely those of the
Eurobarometer project of the European Union and a questionnaire developed by the
World Health Organization. The Thai module was constructed in such a way that
results could be benchmarked against those of the other survey tools, to allow
international comparison. The Thai experience showed that close collaboration
between the relevant national authorities allowed smooth integration of a module
on antibiotic awareness into the national household survey. To date, evidence
from the module has informed the content and strategy of public communications on
antibiotic use and misuse. Work is under way to select the most robust indicators
to use in monitoring progress. The other Member States of the World Health
Organization South-East Asia Region can benefit from Thailand's experiences in
improvement of monitoring population knowledge and awareness.
DOI: 10.4103/2224-3151.239417
PMID: 30136664 [Indexed for MEDLINE]
Kaninjing E(1), Lopez I(2), Nguyen J(1), Odedina F(1), Young ME(3).
Author information:
(1)1 Department of Pharmacotherapy and Translational Research, College of
Pharmacy, University of Florida, Orlando, FL, USA.
(2)2 Institute of Public Health, Florida A&M University, Tallahassee, FL, USA.
(3)3 Department of Occupational Therapy, College of Public Health and Health
Professions, University of Florida, Gainesville, FL, USA.
Prostate Cancer (CaP) is the most commonly diagnosed cancer among Cameroonian
men. Due to inadequate infrastructure, record keeping, and resources, little is
known about its true burden on the population. There are rural/urban disparities
with regards to awareness, screening, treatment, and survivorship. Furthermore,
use of traditional medicine and homeopathic remedies is widespread, and some men
delay seeking conventional medical treatment until advanced stages of CaP. This
study examined the perceptions, beliefs, and practices of men in Cameroon
regarding late stage CaP diagnoses; identified factors that influence screening
decision; and ascertained how men decided between traditional or conventional
medicine for CaP diagnosis and treatment. Semistructured focus groups were used
to collect data from men in Bamenda, Cameroon. Qualitative data analysis was used
to analyze transcripts for emerging themes and constructs using a
socio-ecological framework. Twenty-five men participated in the study, with an
average age of 59. Most of the participants had never received a prostate
screening recommendation. Socioeconomic status, local beliefs, knowledge levels,
awareness of CaP and screening methods, and stigma were prominent themes. A
significant number of Cameroonian men receive late stage CaP diagnosis due to
lack of awareness, attitudes, cultural beliefs, self-medication, and economic
limitation. To effectively address these contributing factors to late stage CaP
diagnosis, a contextually based health education program is warranted and should
be tailored to fill knowledge gaps about the disease, dispel misconceptions, and
focus on reducing barriers to utilization of health services.
DOI: 10.1177/1557988318768596
PMCID: PMC6142138
PMID: 29658388 [Indexed for MEDLINE]
Author information:
(1)Health and Society (HSO) group, Wageningen University and Research,
Wageningen, The Netherlands.
(2)Institute for Medical Research and Medicinal Plant studies (IMPM), Yaoundé,
Cameroon.
(3)Knowledge Technology and Innovation (KTI) group, Hollandseweg 1, Wageningen
University and Research, Wageningen, The Netherlands.
Creating better access to good quality healthcare for the poor is a major
challenge to development. In this study, we examined inter-linkages between
poverty and disease, referred to as poverty-related diseases (PRDs), by
investigating how Cameroon Development Corporation (CDC) camp dwellers respond to
diseases that adversely affect their health and wellbeing. Living in plantation
camps is associated with poverty, overcrowding, poor sanitation and the rapid
spread of diseases. In a survey of 237 CDC camp dwellers in Cameroon, we used the
health belief model to understand the drivers (perceived threats, benefits and
cues for treatment seeking) of reported responses. Using logistic regression
analysis, we looked for trends in people's response to malaria. We calculated the
odds ratio of factors shown to have an influence on people's health, such as
food, water, sanitation challenges and seeking formal healthcare for malaria.
Malaria (40.3%), cholera (20.8%) and diarrhoea (17.7%) were the major PRDs
perceived by camp dwellers. We found a strong link between what respondents
perceived as PRDS and hygiene conditions. Poverty for our respondents was more
about living in poor hygiene conditions than lack of money. Respondents perceived
health challenges as stemming from their immediate living environment. Moreover,
people employed self-medication and other informal health practices to seek
healthcare. Interestingly, even though respondents reported using formal
healthcare services as a general response to illness (84%), almost 90% stated
that, in the case of malaria, they would use informal healthcare services. Our
study recommends that efforts to curb the devastating effects of PRDs should have
a strong focus on perceptions (i.e. include diseases that people living in
conditions of poverty perceive as PRDs) and on hygiene practices, emphasising how
they can be improved. By providing insights into the inter-linkages between
poverty and disease, our study offers relevant guidance for potentially
successful health promotion interventions.
DOI: 10.1371/journal.pntd.0006100
PMCID: PMC5714393
PMID: 29155825 [Indexed for MEDLINE]
Malaria Hyperendemicity and Risk for Artemisinin Resistance among Illegal Gold
Miners, French Guiana.
Pommier de Santi V, Djossou F, Barthes N, Bogreau H, Hyvert G, Nguyen C, Pelleau
S, Legrand E, Musset L, Nacher M, Briolant S.
To assess the prevalence of malaria among illegal gold miners in the French
Guiana rainforest, we screened 205 miners during May-June 2014. Malaria
prevalence was 48.3%; 48.5% of cases were asymptomatic. Patients reported
self-medication with artemisinin-based combination therapy. Risk for emergence
and spread of artemisinin resistance among gold miners in the rainforest is high.
DOI: 10.3201/eid2205.151957
PMCID: PMC4861531
PMID: 27089004 [Indexed for MEDLINE]
573. Philos Trans R Soc Lond B Biol Sci. 2015 May 26;370(1669). pii: 20140115. doi:
10.1098/rstb.2014.0115.
Nunn CL(1), Craft ME(2), Gillespie TR(3), Schaller M(4), Kappeler PM(5).
Author information:
(1)Department of Evolutionary Anthropology, Duke University, Box 90383, Durham,
NC 27708, USA Duke Global Health Institute, Duke University, 310 Trent Drive,
Durham, NC 27710, USA charles.nunn@duke.edu.
(2)Department of Veterinary Population Medicine, University of Minnesota, St
Paul, MN 55108, USA.
(3)Department of Environmental Sciences and Program in Population Biology,
Ecology and Evolution, Emory University, Atlanta, GA 30322, USA Department of
Environmental Health, Rollins School of Public Health, Emory University, Atlanta,
GA 30322, USA.
(4)Department of Psychology, University of British Columbia, 2136 West Mall,
Vancouver, British Columbia, Canada V6T1Z4.
(5)Behavioral Ecology and Sociobiology Unit, German Primate Center, Göttingen,
Germany Department of Sociobiology/Anthropology, University of Göttingen,
Göttingen, Germany.
This theme issue has highlighted the links between sociality, health and fitness
in a broad range of organisms, and with approaches that include field and captive
studies of animals, comparative and meta-analyses, theoretical modelling and
clinical and psychological studies of humans. In this concluding chapter, we
synthesize the results of these diverse studies into some of the key concepts
discussed in this issue, focusing on risks of infectious disease through social
contact, the effects of competition in groups on susceptibility to disease, and
the integration of sociality into research on life-history trade-offs.
Interestingly, the studies in this issue both support pre-existing hypotheses,
and in other ways challenge those hypotheses. We focus on unexpected results,
including a lack of association between ectoparasites and fitness and weak
results from a meta-analysis of the links between dominance rank and immune
function, and place these results in a broader context. We also review relevant
topics that were not covered fully in this theme issue, including self-medication
and sickness behaviours, society-level defences against infectious disease,
sexual selection, evolutionary medicine, implications for conservation biology
and selective pressures on parasite traits. We conclude by identifying general
open questions to stimulate and guide future research on the links between
sociality, health and fitness.
© 2015 The Author(s) Published by the Royal Society. All rights reserved.
DOI: 10.1098/rstb.2014.0115
PMCID: PMC4410381
PMID: 25870401 [Indexed for MEDLINE]
574. Ther Adv Drug Saf. 2018 Jun;9(6):309-321. doi: 10.1177/2042098618764536. Epub
2018 Mar 26.
Vanwesemael T(1), Boussery K(2), van den Bemt P(3), Dilles T(4).
Author information:
(1)Department of Nursing Science and Midwifery, Centre for Research and
Innovation in Care (CRIC), Nurse and Pharmaceutical Care (NuPhac), Faculty of
Medicine and Health Sciences, University of Antwerp, Universiteitsplein 1, 2610
Wilrijk, Belgium.
(2)Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent
University, Ghent, Belgium.
(3)Department of Hospital Pharmacy, Erasmus University Medical Center's
Gravendijkwal, CE Rotterdam, The Netherlands.
(4)Department of Healthcare, Thomas More University College, Lier, Belgium.
DOI: 10.1177/2042098618764536
PMCID: PMC5971398
PMID: 29854392
Can the intake of antiparasitic secondary metabolites explain the low prevalence
of hemoparasites among wild Psittaciformes?
Masello JF(1), Martínez J(2), Calderón L(3), Wink M(4), Quillfeldt P(3), Sanz
V(5), Theuerkauf J(6), Ortiz-Catedral L(7), Berkunsky I(8), Brunton D(7),
Díaz-Luque JA(9)(10), Hauber ME(11), Ojeda V(12), Barnaud A(13), Casalins L(12),
Jackson B(14)(15), Mijares A(16), Rosales R(16), Seixas G(17), Serafini P(18),
Silva-Iturriza A(16), Sipinski E(19), Vásquez RA(20), Widmann P(21), Widmann
I(21), Merino S(22).
Author information:
(1)Department of Animal Ecology and Systematics, Justus-Liebig Universität
Gießen, Heinrich-Buff-Ring 26, D-35392, Gießen, Germany.
juan.f.masello@bio.uni-giessen.de.
(2)Departamento de Biomedicina y Biotecnologıía, Area Parasitologıía, Facultad de
Farmacia, Universidad de Alcalá (UAH), NII Km 33.600, 28805 Alcalá de Henares,
Madrid, Spain.
(3)Department of Animal Ecology and Systematics, Justus-Liebig Universität
Gießen, Heinrich-Buff-Ring 26, D-35392, Gießen, Germany.
(4)Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF
364, 69120, Heidelberg, Germany.
(5)Centro de Ecología, Instituto Venezolano de Investigaciones Científicas, Altos
de Pipe, Venezuela.
(6)Museum and Institute of Zoology, Polish Academy of Sciences, Wilcza 64,
00-679, Warsaw, Poland.
(7)Institute of Natural and Mathematical Sciences, Massey University, Auckland,
New Zealand.
(8)Instituto Multidisciplinario sobre Ecosistemas y Desarrollo Sustentable,
Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil,
Argentina.
(9)Fundación para la Investigación y la Conservación de los Loros en Bolivia
(CLB), Avenida Francisco Mora, Santa Cruz de la Sierra, Bolivia.
(10)Centro de Conservación de Loros Silvestres (CREA), Santa Cruz de la Sierra,
Bolivia.
(11)Department of Animal Biology, School of Integrative Biology, University of
Illinois, Urbana-Champaign, IL, 61801, USA.
(12)ZoologyDepartment (CRUB-UNCo), INIBIOMA (Universidad Nacional del
Comahue-CONICET), 8400, Bariloche, Argentina.
(13)Province des Iles Loyauté, Direction du Développement Economique, BP 50
98820, Wé, Lifou, New Caledonia.
(14)Auckland Zoological Park, Motions Road, Western Springs, Auckland, 1022, New
Zealand.
(15)School of Veterinary and Life Sciences, Murdoch University, Perth, WA,
Australia.
(16)Centro de Bioquímica y Biofísica, Instituto Venezolano de Investigaciones
Científicas, Altos de Pipe, Venezuela.
(17)Projeto Papagaio-verdadeiro, Fundação Neotropica do Brasil, Campo Grande,
Brazil.
(18)Base Multifuncional do CEMAVE em Florianópolis/SC, Estação Ecológica Carijós
- ICMBio, Florianópolis, Brazil.
(19)Projeto de Conservação do papagaio-de-cara-roxa, SPVS - Sociedade de Pesquisa
em Vida Selvagem e Educação Ambiental, Curitiba, Brazil.
(20)Institute of Ecology and Biodiversity, Departamento de Ciencias Ecológicas,
Facultad de Ciencias Universidad de Chile, Santiago, Chile.
(21)Katala Foundation, Inc., Puerto Princesa City, Palawan, Philippines.
(22)Departamento de Ecología Evolutiva, Museo Nacional de Ciencias Naturales,
Consejo Superior de Investigaciones Científicas, 28006, Madrid, Spain.
BACKGROUND: Parasites can exert selection pressure on their hosts through effects
on survival, on reproductive success, on sexually selected ornament, with
important ecological and evolutionary consequences, such as changes in population
viability. Consequently, hemoparasites have become the focus of recent avian
studies. Infection varies significantly among taxa. Various factors might explain
the differences in infection among taxa, including habitat, climate, host
density, the presence of vectors, life history and immune defence. Feeding
behaviour can also be relevant both through increased exposure to vectors and
consumption of secondary metabolites with preventative or therapeutic effects
that can reduce parasite load. However, the latter has been little investigated.
Psittaciformes (parrots and cockatoos) are a good model to investigate these
topics, as they are known to use biological control against ectoparasites and to
feed on toxic food. We investigated the presence of avian malaria parasites
(Plasmodium), intracellular haemosporidians (Haemoproteus, Leucocytozoon),
unicellular flagellate protozoans (Trypanosoma) and microfilariae in 19
Psittaciformes species from a range of habitats in the Indo-Malayan, Australasian
and Neotropical regions. We gathered additional data on hemoparasites in wild
Psittaciformes from the literature. We considered factors that may control the
presence of hemoparasites in the Psittaciformes, compiling information on diet,
habitat, and climate. Furthermore, we investigated the role of diet in providing
antiparasitic secondary metabolites that could be used as self-medication to
reduce parasite load.
RESULTS: We found hemoparasites in only two of 19 species sampled. Among them,
all species that consume at least one food item known for its secondary
metabolites with antimalarial, trypanocidal or general antiparasitic properties,
were free from hemoparasites. In contrast, the infected parrots do not consume
food items with antimalarial or even general antiparasitic properties. We found
that the two infected species in this study consumed omnivorous diets. When we
combined our data with data from studies previously investigating blood parasites
in wild parrots, the positive relationship between omnivorous diets and
hemoparasite infestation was confirmed. Individuals from open habitats were less
infected than those from forests.
CONCLUSIONS: The consumption of food items known for their secondary metabolites
with antimalarial, trypanocidal or general antiparasitic properties, as well as
the higher proportion of infected species among omnivorous parrots, could explain
the low prevalence of hemoparasites reported in many vertebrates.
DOI: 10.1186/s13071-018-2940-3
PMCID: PMC6008929
PMID: 29921331 [Indexed for MEDLINE]
576. J Res Med Sci. 2018 Mar 27;23:26. doi: 10.4103/jrms.JRMS_629_17. eCollection
2018.
Author information:
(1)Medical Toxicology Research Center, Mashhad University of Medical Sciences,
Mashhad, Iran.
(2)Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute,
Mashhad University of Medical Sciences, Mashhad, Iran.
(3)Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad
University of Medical Sciences, Mashhad, Iran.
Background: For many years, medicinal plants and herbal therapy have been widely
used in different societies for the treatment of various diseases. Besides their
therapeutic potency, some of the medicinal plants have strong toxicity in human,
especially in children and elderly. Despite common beliefs that natural products
are safe, there have been few reports on their toxicities.
Materials and Methods: In the present study, we aimed to systematically review
the literature wherein acute plant poisoning and herbal intoxication have been
reported in pediatric patients. After literature search and selection of the
appropriate documents, the desired data were extracted and described
qualitatively.
Results: A total of 127 articles with overall 1453 intoxicated cases were
collected. The results of this study showed that some medicinal plants can cause
acute poisoning and complications such as hepatic and renal failure in children.
Conclusion: The findings of this survey showed that acute plant poisoning can be
life?threatening in children, and since a single?ingested dose of toxic plants
can cause acute poisoning, parents should be aware of these toxic effects and
compare the side effects of self?medication with its potential benefits.
DOI: 10.4103/jrms.JRMS_629_17
PMCID: PMC5894275
PMID: 29692823
Aziz H(1), Hatah E(2), Makmor-Bakry M(3), Islahudin F(4), Ahmad Hamdi N(5), Mok
Pok Wan I(6).
Author information:
(1)PhD, MPharm (Clin), Bpharm (Hons), Faculty of Pharmacy Universiti Kebangsaan
Malaysia jalan Raja Muda Abdul Aziz 50300 Kuala Lumpur, Malaysia. Email address:
ernieda@ukm.edu.my.
(2)Bpharm (Hons), Master of Science (Pharm), Faculty of Pharmacy, Universiti
Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur Malaysia.
(3)PhD, MPharm (Clin), Bpharm (Hons), Faculty of Pharmacy, Universiti Kebangsaan
Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur Malaysia.
(4)Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul
Aziz, Kuala Lumpur Malaysia.
(5)Bpharm (Hons), Pharmacy Division, Ministry of Health Jalan Universiti,
Petaling Jaya Selangor, Malaysia.
(6)MPharm (Clin), Bpharm Universiti Kebangsaan Malaysia Medical Centre, Jalan
Yaacob Latif Bandar Tun Razak, 56000 Cheras Kuala Lumpur, Malaysia.
Background: Limited efforts have been made to evaluate medication adherence among
subsidized and self-paying patients.
Objective: To investigate medication adherence among patients with and without
medication subsidies and to identify factors that may influence patients'
adherence to medication. Setting: Government healthcare institutions in Kuala
Lumpur, Selangor, and Negeri Sembilan and private healthcare institutions in
Selangor and Negeri Sembilan, Malaysia.
Methods: This cross-sectional study sampled patients with and without medication
subsidies (self-paying patients). Only one of the patient's medications was
re-packed into Medication Event Monitoring Systems (MEMS) bottles, which were
returned after four weeks. Adherence was defined as the dose regimen being
executed as prescribed on 80% or more of the days. The factors that may influence
patients' adherence were modelled using binary logistic regression. Main outcome
measure: Percentage of medication adherence.
Results: A total of 97 patients, 50 subsidized and 47 self-paying, were included
in the study. Medication adherence was observed in 50% of the subsidized patients
and 63.8% of the self-paying patients (χ2=1.887, df=1, p=0.219). None of the
evaluated variables had a significant influence on patients' medication
adherence, with the exception of attending drug counselling. Patients who
attended drug counselling were found to be 3.3 times more likely to adhere to
medication than those who did not (adjusted odds ratio of 3.29, 95% CI was 1.42
to 7.62, p = 0.006).
Conclusion: There is no significant difference in terms of medication adherence
between subsidized and self-paying patients. Future studies may wish to consider
evaluating modifiable risk factors in the examination of non-adherence among
subsidized and self-paying patients in Malaysia.
PMCID: PMC6173959
PMID: 30302177
Gandhi S(1), Pavalur R(1), Thanapal S(2), Parathasarathy NB(3), Desai G(2), Bhola
P(4), Philip M(5), Chaturvedi SK(2).
Author information:
(1)Department of Nursing, National Institute of Mental Health and Neurosciences,
Bangalore, Karnataka, India.
(2)Department of Psychiatry, National Institute of Mental Health and
Neurosciences, Bangalore, Karnataka, India.
(3)Department of Psychiatric Social Work, National Institute of Mental Health and
Neurosciences, Bangalore, Karnataka, India.
(4)Department of Clinical Psychology, National Institute of Mental Health and
Neurosciences, Bangalore, Karnataka, India.
(5)Department of Biostatics, National Institute of Mental Health and
Neurosciences, Bangalore, Karnataka, India.
DOI: 10.4103/0253-7176.140724
PMCID: PMC4201791
PMID: 25336771
Author information:
(1)Unit for Suicide Research, Ghent University, Ghent, Belgium.
(2)Flemish Centre of Expertise in Suicide Prevention, Ghent University, Ghent,
Belgium.
DOI: 10.1371/journal.pone.0216317
PMCID: PMC6497282
PMID: 31048918
Author information:
(1)Faculdade de Enfermagem, Universidade Estadual de Campinas, Campinas, SP,
Brazil.
(2)Faculdade de Enfermagem, Universidade Estadual de Campinas, Campinas, SP,
Brasil.
DOI: 10.1590/1518-8345.0167.2692
PMCID: PMC4877142
PMID: 27192417 [Indexed for MEDLINE]
581. Adv Biomed Res. 2017 May 29;6:63. doi: 10.4103/2277-9175.190997. eCollection
2017.
DOI: 10.4103/2277-9175.190997
PMCID: PMC5458405
PMID: 28603704
582. Int J Environ Res Public Health. 2019 May 18;16(10). pii: E1762. doi:
10.3390/ijerph16101762.
Abd Rashid R(1)(2), Kanagasundram S(3), Danaee M(4), Abdul Majid H(5)(6),
Sulaiman AH(7), Ahmad Zahari MM(8), Ng CG(9), Francis B(10), Wan Husin WAI(11),
Su TT(12)(13).
Author information:
(1)University of Malaya Centre of Addiction Sciences (UMCAS), University of
Malaya, Kuala Lumpur 50603, Malaysia. rusdi@ummc.edu.my.
(2)Department of Psychological Medicine, Faculty of Medicine, University of
Malaya, Kuala Lumpur 50603, Malaysia. rusdi@ummc.edu.my.
(3)Department of Psychological Medicine, Faculty of Medicine, University of
Malaya, Kuala Lumpur 50603, Malaysia. sharmilla_kanagasundram@yahoo.com.
(4)Department of Social and Preventive Medicine, Faculty of Medicine, University
of Malaya, Kuala Lumpur 50603, Malaysia. mdanaee@um.edu.my.
(5)Department of Social and Preventive Medicine, Faculty of Medicine, University
of Malaya, Kuala Lumpur 50603, Malaysia. hazreen@ummc.edu.my.
(6)Centre for Population Health (CePH), Department of Social and Preventive
Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603,
Malaysia. hazreen@ummc.edu.my.
(7)Department of Psychological Medicine, Faculty of Medicine, University of
Malaya, Kuala Lumpur 50603, Malaysia. hatim@um.edu.my.
(8)Department of Psychological Medicine, Faculty of Medicine, University of
Malaya, Kuala Lumpur 50603, Malaysia. muhsin@ummc.edu.my.
(9)Department of Psychological Medicine, Faculty of Medicine, University of
Malaya, Kuala Lumpur 50603, Malaysia. chong_guan@um.edu.my.
(10)Department of Psychological Medicine, Faculty of Medicine, University of
Malaya, Kuala Lumpur 50603, Malaysia. ben.franciscan@gmail.com.
(11)University of Malaya Centre of Addiction Sciences (UMCAS), University of
Malaya, Kuala Lumpur 50603, Malaysia. irnee84_umcas@um.edu.my.
(12)Centre for Population Health (CePH), Department of Social and Preventive
Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603,
Malaysia. tstin@ummc.edu.my.
(13)South East Asia Community Observatory (SEACO), Monash University Malaysia,
Bandar Sunway 47500, Malaysia. tstin@ummc.edu.my.
Objective: This study was conducted to assess the prevalence, pattern of smoking
and sociodemographic factors among Kerinchi residents in Kuala Lumpur, as well as
to identify the association between smoking, stress, anxiety and depression.
Methods: This study was carried out at four community housing projects in the
Lembah Pantai area in Kuala Lumpur. Data was collected between 3 February 2012,
and 29 November 2012. Data collectors made house visits and used interviewer
administered questionnaires containing questions on demographic data and smoking
patterns. Depression anxiety stress scale (DASS) was used to assess psychological
symptoms. Alcohol smoking and substance involvement screening tool (ASSIST) scale
was used to assess nicotine use. Results: Data from 1989 individuals (833
households) showed the age of respondents ranged from 18 to 89 years and the mean
age was 39.12 years. There were 316 smokers indicating the prevalence of smoking
was 15.85%, with 35.5% among males and 1.8% among females. Further, 86.6% of
smokers were Malay and 87% were Muslims. Divorce was associated with smoking.
Unemployment and housewives were less associated with smoking. Depression and
anxiety were significantly associated with smoking (OR = 1.347. 95% CI:
1.042-1.741) and (OR = 1.401. 95% CI: 1.095-1.793) respectively. Conclusion:
Screening for depression and anxiety should be routinely performed in the primary
care setting and in population-based health screening to intervene early in
patients who smoke.
DOI: 10.3390/ijerph16101762
PMCID: PMC6571886
PMID: 31109033
583. BMC Health Serv Res. 2018 Aug 6;18(1):605. doi: 10.1186/s12913-018-3417-y.
Aziz H(1), Hatah E(2), Makmor-Bakry M(3), Islahudin F(3), Ahmad Hamdi N(4), Mok
Pok Wan I(5).
Author information:
(1)Pharmacy Department, Putrajaya Hospital, Federal Government Administrative
Centre, Precinct 7, 62250, Putrajaya, Malaysia.
(2)Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul
Aziz, 50300, Kuala Lumpur, Malaysia. ernieda@ukm.edu.my.
(3)Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul
Aziz, 50300, Kuala Lumpur, Malaysia.
(4)Family Health Development Division, Ministry of Health, Parcel E, Federal
Government Administrative Centre, 62590, Putrajaya, Malaysia.
(5)Pharmacy Department, Universiti Kebangsaan Malaysia Medical Centre, Jalan
Yaacob Latif, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, Malaysia.
DOI: 10.1186/s12913-018-3417-y
PMCID: PMC6080501
PMID: 30081892 [Indexed for MEDLINE]
Author information:
(1)Institute of Communication and Health, Università della Svizzera italiana ,
Lugano, Switzerland.
DOI: 10.4081/jphr.2016.762
PMCID: PMC5206775
PMID: 28083523
Lubrano R(1), Paoli S(2), Bonci M(3), Di Ruzza L(4), Cecchetti C(5), Falsaperla
R(6), Pavone P(7), Matin N(8), Vitaliti G(9)(10), Gentile I(11).
Author information:
(1)Department of Pediatrics, La Sapienza University of Rome, Rome, Italy.
riccardo.lubrano@uniroma1.it.
(2)Department of Pediatrics, La Sapienza University of Rome, Rome, Italy.
sara.paoli@hotmail.it.
(3)Paediatrics Operative Unit, Grassi Hospital, Rome, Italy.
bonci.marco@gmail.com.
(4)Paediatrics Operative Unit, Policlinico Umberto I, Frosinone, Italy.
luidir@alice.it.
(5)Acute and Emergency Operative Unit, Bambino Gesù Paediatric Hospital, Rome,
Italy. corrado.cecchetti@opbg.net.
(6)General Paediatrics and Acute and Emergency Paediatrics Operative Unit,
Vittorio Emanuele University Hospital, Catania, Italy. r.falsaperla@ao-ve.it.
(7)General Paediatrics and Acute and Emergency Paediatrics Operative Unit,
Vittorio Emanuele University Hospital, Catania, Italy. ppavone@unict.it.
(8)University Medical Science of Teheran, University of Teheran, Teheran, Italy.
nsmatn@yahoo.com.
(9)Department of Pediatrics, La Sapienza University of Rome, Rome, Italy.
giovitaliti@yahoo.it.
(10)AOU Policlinico-OVE, University of Catania, Via Plebiscito n. 628, 95100,
Catania, Italy. giovitaliti@yahoo.it.
(11)Department of Pediatrics, La Sapienza University of Rome, Rome, Italy.
isottagentile@libero.it.
DOI: 10.1186/s13052-016-0219-x
PMCID: PMC4769520
PMID: 26920747 [Indexed for MEDLINE]
Sleath B(1), Carpenter DM(2), Blalock SJ(2), Davis SA(2), Hickson RP(2), Lee
C(3), Ferreri SP(4), Scott JE(5), Rodebaugh LB(6), Cummings DM(7).
Author information:
(1)Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of
Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, USA;
Cecil G. Sheps Center for Health Services Research, The University of North
Carolina at Chapel Hill, Chapel Hill, USA.
(2)Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of
Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, USA.
(3)Polyglot Systems, Inc., Morrisville, USA.
(4)Division of Practice Advancement and Clinical Education, UNC Eshelman School
of Pharmacy, Chapel Hill, USA.
(5)Consortium for Implementation Science, Department of Health Policy and
Management, Gillings School of Global Public Health, The University of North
Carolina at Chapel Hill, Chapel Hill, USA.
(6)Department of Family Medicine, Brody School of Medicine, East Carolina
University, Greenville, USA.
(7)Department of Family Medicine, Brody School of Medicine, East Carolina
University, Greenville, USA; Department of Public Health, Brody School of
Medicine, East Carolina University, Greenville, NC, USA.
BACKGROUND: Although there are several different general diabetes self-efficacy
scales, there is a need to develop a self-efficacy scale that providers can use
to assess patient's self-efficacy regarding medication use. The purpose of this
study was to: 1) develop a new diabetes medication self-efficacy scale and 2)
examine how diabetes medication self-efficacy is associated with patient-reported
problems in using diabetes medications and self-reported adherence.
PATIENTS AND METHODS: Adult English-speaking patients with type 2 diabetes were
recruited from a family medicine clinic and a pharmacy in Eastern North Carolina,
USA. The patients were eligible if they reported being nonadherent to their
diabetes medicines on a visual analog scale. Multivariable regression was used to
examine the relationship between self-efficacy and the number of reported
diabetes medication problems and adherence.
RESULTS: The diabetes medication self-efficacy scale had strong reliability
(Cronbach's alpha =0.86). Among a sample (N=51) of mostly African-American female
patients, diabetes medication problems were common (6.1±3.1) and a greater number
of diabetes medications were associated with lower medication adherence (odds
ratio: 0.35; 95% confidence interval: 0.13, 0.89). Higher medication
self-efficacy was significantly related to medication adherence (odds ratio:
1.17; 95% confidence interval: 1.05, 1.30) and inversely related to the number of
self-reported medication problems (β=-0.13; P=0.006).
CONCLUSION: Higher diabetes medication self-efficacy was associated with fewer
patient-reported medication problems and better medication adherence. Assessing
medication-specific self-efficacy may help to identify medication-related
problems that providers can help the patients address, potentially improving
adherence and patient outcomes.
DOI: 10.2147/PPA.S101349
PMCID: PMC4908948
PMID: 27354769
Takahara M(1)(2), Shiraiwa T(3), Ogawa N(4), Katakami N(2), Matsuoka TA(2),
Shimomura I(2).
Author information:
(1)1Department of Diabetes Care Medicine, Osaka University Graduate School of
Medicine, 2-2, Yamadaoka, Suita City, Osaka 565-0871 Japan.
(2)2Department of Metabolic Medicine, Osaka University Graduate School of
Medicine, 2-2, Yamadaoka, Suita City, Osaka 565-0871 Japan.
(3)Shiraiwa Medical Clinic, Shiraiwa Medical Clinic, 4-10-24 Hozenji, Kashiwara
City, Osaka 582-0005 Japan.
(4)Smile Pharmacy, 4-10-25 Hozenji, Kashiwara City, Osaka 582-0005 Japan.
DOI: 10.1007/s13340-016-0265-z
PMCID: PMC6224975
PMID: 30603292
Impact of training of mothers, drug shop attendants and voluntary health workers
on effective diagnosis and treatment of malaria in Lagos, Nigeria.
Ajibaye O(1), Balogun EO(2)(3), Olukosi YA(1), Orok BA(1), Oyebola KM(1),
Iwalokun BA(4), Aina OO(1), Shittu O(5), Adeneye AK(6), Ojewunmi OO(7), Kita
K(6), Awolola ST(8).
Author information:
(1)Department of Biochemistry and Nutrition, Nigerian Institute of Medical
Research, Yaba, Lagos, Nigeria.
(2)Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
(3)Department of Biomedical Chemistry, Graduate School of Medicine, The
University of Tokyo, Tokyo, Japan.
(4)Department of Molecular Biology and Biotechnology, Nigerian Institute of
Medical Research, Yaba, Lagos, Nigeria.
(5)Department of Zoology, Parasitology Unit, University of Ilorin, Ilorin,
Nigeria.
(6)School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki,
Japan.
(7)Sickle Cell Foundation on Nigeria, Idi-Araba, Lagos, Nigeria.
(8)Department of Public Health and Molecular Entomology, Nigerian Institute of
Medical Research, Yaba, Lagos, Nigeria.
DOI: 10.4103/tp.TP_36_18
PMCID: PMC6542308
PMID: 31161091
Author information:
(1)Centre for Dermatology Research, Manchester Academic Health Science Centre,
University of Manchester, Manchester, U.K.
(2)School of Biological Sciences, Manchester Academic Health Science Centre,
University of Manchester, Manchester, U.K.
(3)Centre for Pharmacoepidemiology and Drug Safety, School of Health Sciences,
Manchester Academic Health Science Centre, University of Manchester, Manchester,
U.K.
(4)Salford Royal NHS Foundation Trust, Manchester, U.K.
(5)Division of Musculoskeletal and Dermatological Sciences, University of
Manchester, Manchester, U.K.
Comment in
Br J Dermatol. 2017 Mar;176(3):558-559.
© 2016 The Authors. British Journal of Dermatology published by John Wiley & Sons
Ltd on behalf of British Association of Dermatologists.
DOI: 10.1111/bjd.15086
PMCID: PMC5363250
PMID: 27664406 [Indexed for MEDLINE]
Schumacher KL(1), Plano Clark VL(2), West CM(3), Dodd MJ(3), Rabow MW(3),
Miaskowski C(3).
Author information:
(1)College of Nursing, University of Nebraska Medical Center, Omaha, Nebraska,
USA. Electronic address: kschumacher@unmc.edu.
(2)University of Cincinnati, Cincinnati, Ohio, USA.
(3)University of California, San Francisco, San Francisco, California, USA.
Comment in
J Pain Symptom Manage. 2014 Nov;48(5):760-1.
DOI: 10.1016/j.jpainsymman.2013.12.242
PMCID: PMC4185257
PMID: 24704800 [Indexed for MEDLINE]
Zaidi SMA(1), Haseeb A(2), Habib SS(3), Malik A(1), Khowaja S(1), SaifUllah N(2),
Rizvi N(2).
Author information:
(1)Interactive Research & Development, Suite 508, Ibrahim Trade Tower, Main
Shahrah-e-Faisal, Karachi, Pakistan.
(2)Department of Chest Medicine, Jinnah Post Graduate Medical Centre, Rafiqi H J
Rd, Karachi, Pakistan.
(3)Interactive Research & Development, Suite 508, Ibrahim Trade Tower, Main
Shahrah-e-Faisal, Karachi, Pakistan. shifa.habib@irdresearch.org.
DOI: 10.1186/s13104-017-2633-6
PMCID: PMC5526320
PMID: 28743312 [Indexed for MEDLINE]
Abdelaziz AI(1), Tawfik AG(2), Rabie KA(3), Omran M(4), Hussein M(5), Abou-Ali
A(6), Ahmed AF(7).
Author information:
(1)Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia
61519, Egypt. abdullahislam.mu@gmail.com.
(2)Department of Pharmacology and Toxicology, Faculty of Pharmacy, Deraya
University, Minia 61512, Egypt. abdelrahman.gamal@deraya.edu.eg.
(3)Medical Representative, Novartis 61519, Egypt. khalid.ahmed.rabie@gmail.com.
(4)Community Pharmacist, Minia 61519, Egypt. muhammad.o.yusef@gmail.com.
(5)Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee,
Milwaukee, WI 53201, USA. husseimh@uwm.edu.
(6)Global Safety Officer at Sanofi Pasteur, Toronto Area, ON M2R 3T4, Canada.
adel.abouali@gmail.com.
(7)Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia
University, Minia 61519, Egypt. shaimaa.faissal@minia.edu.eg.
DOI: 10.3390/antibiotics8020035
PMCID: PMC6627069
PMID: 30939797
593. BMC Complement Altern Med. 2018 Mar 15;18(1):92. doi: 10.1186/s12906-018-2160-
6.
Why people use herbal medicine: insights from a focus-group study in Germany.
Author information:
(1)TUM Campus Straubing for Biotechnology and Sustainability,
Weihenstephan-Triesdorf University of Applied Sciences, Petersgasse 18, 94315,
Straubing, Germany.
(2)TUM Campus Straubing for Biotechnology and Sustainability,
Weihenstephan-Triesdorf University of Applied Sciences, Petersgasse 18, 94315,
Straubing, Germany. klaus.menrad@hswt.de.
DOI: 10.1186/s12906-018-2160-6
PMCID: PMC5855977
PMID: 29544493 [Indexed for MEDLINE]
Zheng J(1), Wang Y(2), Ye X(3), Xiao L(4), Ye J(5), Li X(6), Zhong M(1).
Author information:
(1)Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai 200040,
China, hsmkzhong@hotmail.com.
(2)Health Services and Systems Research, Duke-NUS Medical School, Singapore
169857, Singapore.
(3)Department of Endocrinology, Xiamen Municipal Hospital of Traditional Chinese
Medicine, Xiamen 361009, China.
(4)Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai
201508, China.
(5)School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350001,
China.
(6)Department of Psychology, School of Social Development and Public Policy,
Fudan University, Shanghai 200433, China, lixiaoru@fudan.edu.cn.
Aims: Greater diabetes medication self-efficacy has been shown to associate with
better medication adherence, which is critical for disease control for people
living with type 2 diabetes (T2D). The Diabetes Medication Self-efficacy Scale
(DMSS) is a 19-item instrument to measure diabetes medication self-efficacy. The
aim of the current study was to translate the DMSS into Chinese and validate the
Chinese version of DMSS (CDMSS) among Chinese T2D patients.
Methods: The CDMSS was translated using forward-backward method, and its validity
and reliability were assessed among 257 Chinese T2D patients. Exploratory factor
analysis, Cronbach's α and Spearman's rank correlation coefficients were used to
evaluate the psychometric properties of CDMSS. Receiver operating characteristic
analysis was used to assess the discrimination of CDMSS for medication adherence
and glycemic control.
Results: Exploratory factor analysis has generated a one-factor structure of the
11-item version of CDMSS (CDMSS-11), which accounted for 63.1% of the variance.
The Spearman's rank correlation coefficient between the original 19-item and
11-item scale was 0.96. The Cronbach's α for internal consistency was 0.94, and
the test-retest reliability coefficient was 0.76. The CDMSS-11 score was
significantly correlated with diabetes distress, medication adherence, as well as
blood levels of fasting plasma glucose and hemoglobin A1c (both P<0.001). The
area under receiver operating characteristic curve and its corresponding 95% CI
was 0.79 (0.73-0.84) for medication adherence, and it was 0.65 (0.57-0.72) for
better glycemic control.
Conclusion: The CDMSS-11 is a valid and reliable measure to assess medication
self-efficacy among Chinese T2D patients.
DOI: 10.2147/PPA.S170144
PMCID: PMC6267354
PMID: 30568430
Author information:
(1)Unit for Medication Outcomes Research and Education (UMORE), Pharmacy, School
of Medicine, Faculty of Health, University of Tasmania, Hobart, 7001, Australia.
(2)Sydney Nursing School, University of Sydney, Sydney, Australia.
(3)Blacktown Hospital, Western Sydney Local Health District, Sydney, Australia.
(4)School of Medicine, Faculty of Health, University of Tasmania, Hobart,
Australia.
(5)Department of Nephrology, Royal Hobart Hospital, Hobart, Australia.
(6)Unit for Medication Outcomes Research and Education (UMORE), Pharmacy, School
of Medicine, Faculty of Health, University of Tasmania, Hobart, 7001, Australia.
tabish.razizaidi@utas.edu.au.
DOI: 10.1186/s12882-017-0583-9
PMCID: PMC5440949
PMID: 28532480 [Indexed for MEDLINE]
Hofer R(1), Choi H(1), Mase R(1)(2), Fagerlin A(1)(2)(3), Spencer M(1), Heisler
M(1)(2).
Author information:
(1)1 University of Michigan, Ann Arbor, MI, USA.
(2)2 Ann Arbor Veterans' Affairs Healthcare System, Ann Arbor, MI, USA.
(3)3 Center for Bioethics and Social Sciences in Medicine, Ann Arbor, MI, USA.
OBJECTIVE: In a randomized controlled trial we compared two models of community
health worker-led diabetes medication decision support for low-income Latino and
African American adults with diabetes. Most outcomes were improved when community
health workers used either an interactive e-Health tool or print materials. This
article investigates mediators and moderators of improved medication adherence in
these two models.
METHOD: Because both programs significantly improved satisfaction with medication
information, medication knowledge, and decisional conflict, we examined whether
improvements in each of these outcomes in turn were associated with improvements
in self-reported medication adherence, and if so, whether these improvements were
mediated by improvements in diabetes self-efficacy or diabetes distress.
Potential moderators of improvement included gender, race/ethnicity, age,
education, insulin use, health literacy, and baseline self-efficacy, diabetes
distress, and A1c.
RESULTS: A total of 176 participants (94%) completed all assessments. After
adjusting for potential confounders, only increased satisfaction with medication
information was correlated with improved medication adherence ( p = .024).
Improved self-efficacy, but not diabetes distress, was associated with
improvements in both satisfaction with medication information and medication
adherence. However, the Sobel-Goodman Mediation test did not support improvements
in self-efficacy as a mechanism by which improved satisfaction led to better
adherence. None of the examined variables achieved statistical significance as
moderators.
CONCLUSIONS: Improvements in satisfaction with medication information but not in
medication knowledge or decision conflict were associated with improvements in
medication adherence. Interventions that target low-income ethnic and racial
minorities may need to focus on increasing participants' satisfaction with
information provided on diabetes medications and not just improving their
knowledge about medications. Future research should explore in more depth other
possible mediators and moderators of improvements in medication adherence in
low-income minority populations.
DOI: 10.1177/1090198116656331
PMCID: PMC5237412
PMID: 27417502 [Indexed for MEDLINE]
Meinema JG(1), van Dijk N(1), Beune EJ(2), Jaarsma DA(3), van Weert HC(1),
Haafkens JA(1).
Author information:
(1)Department of General Practice/Family Medicine, Academic Medical
Center-University of Amsterdam, Amsterdam, the Netherlands.
(2)Department of Social Medicine, Academic Medical Center-University of
Amsterdam, Amsterdam, the Netherlands.
(3)Department of Evidence-based medical education, University Medical Center of
Groningen, Groningen, the Netherlands.
DOI: 10.1371/journal.pone.0133560
PMCID: PMC4534399
PMID: 26267453 [Indexed for MEDLINE]
Messerli M(1)(2), Aschwanden R(1), Buslau M(2), Hersberger KE(1), Arnet I(1).
Author information:
(1)Pharmaceutical Care Research Group, Department of Pharmaceutical Sciences,
University of Basel, Basel, Switzerland.
(2)European Centre for the Rehabilitation of Scleroderma, Reha Rheinfelden,
Rheinfelden, Switzerland.
DOI: 10.2147/PPA.S142653
PMCID: PMC5630072
PMID: 29033556
Conflict of interest statement: Disclosure All authors have completed the ICMJE
uniform disclosure form at www.icmje.org/coi_disclosure.pdf. The authors report
no conflicts of interest in this work and declare no support from any
organization for the submitted work, no financial relationships with any
organizations that might have an interest in the submitted work in the previous 3
years, and no other relationships or activities that could appear to have
influenced the submitted work.
Author information:
(1)Department of Psychology, Washington State University, Pullman, WA, USA.
(2)Department of Psychology, University of Arizona, Tucson, AZ, USA.
DOI: 10.1093/arclin/acy038
PMCID: PMC6454840
PMID: 29912269 [Indexed for MEDLINE]
600. J Pharm Health Care Sci. 2017 Jan 10;3:2. doi: 10.1186/s40780-016-0070-7.
eCollection 2017.
Fujihara H(1), Kogo M(2), Saito I(3), Kawate N(4), Mizuma M(4), Suzuki H(5),
Murayama JI(6), Sasaki T(6).
Author information:
(1)Department of Pharmacy, Showa University Fujigaoka Rehabilitation Hospital,
2-1-1 Fujigaoka, Aoba-ku, Yokohama, Kanagawa 227-8518 Japan ; Department of
Hospital Pharmaceutics, School of Pharmacy, Showa University, 1-5-8 Hatanodai,
Shinagawa-ku, Tokyo, 142-8555 Japan.
(2)Department of Hospital Pharmaceutics, School of Pharmacy, Showa University,
1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555 Japan ; Department of Pharmacy,
Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa,
227-8501 Japan.
(3)Department of Hospital Pharmaceutics, School of Pharmacy, Showa University,
1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555 Japan.
(4)Department of Rehabilitation Medicine, School of Medicine, Showa University,
2-1-1 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501 Japan.
(5)Department of Pharmacy, Showa University Fujigaoka Rehabilitation Hospital,
2-1-1 Fujigaoka, Aoba-ku, Yokohama, Kanagawa 227-8518 Japan.
(6)Department of Hospital Pharmaceutics, School of Pharmacy, Showa University,
1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555 Japan ; Department of Pharmacy,
Showa University Hospital, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666 Japan.
DOI: 10.1186/s40780-016-0070-7
PMCID: PMC5223740
PMID: 28097014
601. PLoS One. 2016 Mar 4;11(3):e0151068. doi: 10.1371/journal.pone.0151068.
eCollection 2016.
Mattern C(1), Pourette D(2)(3), Raboanary E(1), Kesteman T(4), Piola P(1),
Randrianarivelojosia M(4), Rogier C(5).
Author information:
(1)Epidemiology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
(2)Centre Population et Développement (CEPED), Institut de Recherche pour le
Développement, Paris, France.
(3)Université Catholique de Madagascar, Antananarivo, Madagascar.
(4)Malaria research Unit, Institut Pasteur de Madagascar, Antananarivo,
Madagascar.
(5)Institut Pasteur de Madagascar, Antananarivo, Madagascar.
BACKGROUND: Although its incidence has been decreasing during the last decade,
malaria is still a major public health issue in Madagascar. The use of Long
Lasting Insecticidal Nets (LLIN) remains a key malaria control intervention
strategy in Madagascar, however, it encounters some obstacles. The present study
aimed to explore the local terminology related to malaria, information channels
about malaria, attitude towards bed nets, and health care seeking practices in
case of fever. This article presents novel qualitative findings about malaria.
Until now, no such data has been published for Madagascar.
METHODS: A comparative qualitative study was carried out at four sites in
Madagascar, each differing by malaria epidemiology and socio-cultural background
of the populations. Seventy-one semi-structured interviews were conducted with
biomedical and traditional caregivers, and members of the local population. In
addition, observations of the living conditions and the uses of bed net were
conducted.
RESULTS: Due to the differences between local and biomedical perspectives on
malaria, official messages did not have the expected impact on population in
terms of prevention and care seeking behaviors. Rather, most information retained
about malaria was spread through informal information circulation channels. Most
interviewees perceived malaria as a disease that is simple to treat. Tazomoka
("mosquito fever"), the Malagasy biomedical word for malaria, was not used by
populations. Tazo ("fever") and tazomahery ("strong fever") were the terms more
commonly used by members of the local population to refer to malaria related
symptoms. According to local perceptions in all areas, tazo and tazomahery were
not caused by mosquitos. Each of these symptoms required specific health
recourse. The usual fever management strategies consisted of self-medication or
recourse to traditional and biomedical caregivers. Usage of bed nets was
intermittent and was not directly linked to protection against malaria in the
eyes of most Malagasy people.
CONCLUSIONS: This article highlights the conflicting understanding of malaria
between local perceptions and the biomedical establishment in Madagascar. Local
perceptions of malaria present a holistic vision of the disease that includes
various social and cultural dimensions, rather than reflecting one universal
understanding, as in the biomedical image. The consideration of this "holistic
vision" and other socio-cultural aspects surrounding the understanding of malaria
is essential in implementing successful control intervention strategies.
DOI: 10.1371/journal.pone.0151068
PMCID: PMC4778873
PMID: 26943672 [Indexed for MEDLINE]
602. Ann Oncol. 2017 Jun 1;28(6):1260-1267. doi: 10.1093/annonc/mdx100.
The development of a prediction tool to identify cancer patients at high risk for
chemotherapy-induced nausea and vomiting.
Author information:
(1)The Ottawa Hospital Regional Cancer Centre, Ottawa, Canada.
(2)Hong Kong Polytechnic University, Hong Kong.
(3)UC San Diego Moores Cancer Center, La Jolla.
(4)The West Clinic, Memphis, USA.
(5)Institut de Cancérologie Gustave Roussy, Villejuif, France.
(6)Department of Medicine V, University of Heidelberg, Heidelberg, Germany.
(7)Cancer Research Center, University of Warwick, Conventry, UK.
(8)Cancer Center, Clinique de Genolier, Genolier, Switzerland.
Comment in
Ann Oncol. 2017 Jun 1;28(6):1165-1167.
© The Author 2017. Published by Oxford University Press on behalf of the European
Society for Medical Oncology.
DOI: 10.1093/annonc/mdx100
PMCID: PMC5452068
PMID: 28398530 [Indexed for MEDLINE]
603. Case Rep Infect Dis. 2016;2016:4632369. doi: 10.1155/2016/4632369. Epub 2016
Aug
7.
Author information:
(1)USFR Dermatologie, Centre Hospitalier Universitaire Joseph Raseta
Befelatanana, 101 Antananarivo, Madagascar.
(2)Centre d'Infectiologie Charles Mérieux, Université d'Antananarivo, 101
Antananarivo, Madagascar.
(3)APHP, Hôpital Lariboisière, Bactériologie, Centre National de Référence des
Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, 75475
Paris Cedex 10, France.
DOI: 10.1155/2016/4632369
PMCID: PMC4992523
PMID: 27579195
The Effect of Structured Education to Patients Receiving Oral Agents for Cancer
Treatment on Medication Adherence and Self-efficacy.
Author information:
(1)Department of Nursing, Başkent University Ankara Hospital, Ankara, Turkey.
(2)Department of Nursing, Faculty of Health Sciences, Başkent University, Ankara,
Turkey.
OBJECTIVE: This study was conducted to examine the effect of structured education
on medication adherence and self-efficacy through the use of the MASCC Oral Agent
Teaching Tool (MOATT) for patients receiving oral agents for cancer treatment.
METHODS: This quasi-experimental study has been conducted at two hospitals; 41
patients were included in the study. Data were obtained using a questionnaire,
medication adherence self-efficacy scale (MASES), memorial symptom assessment
scale, and a follow-up form (diary). Patients were educated through the use of
the MOATT at a scheduled time; drug-specific information was provided along with
a treatment scheme and follow-up diary. Phone interviews were completed 1 and 2
weeks after the educational session. At the next treatment cycle, the patients
completed the same questionnaires.
RESULTS: Majority of the patients were receiving capecitabine (90.2%; n = 37) as
an oral agent for breast (51.2%; n = 21) and stomach cancer (24.6%; n = 10)
treatment. About 90.2% of patients (n = 37) stated that they did not forget to
take their medication and experienced medication-related side effects (78%; n =
32). The total score of MASES was increased after the education (66.39 vs. 71.04,
P < 0.05).
CONCLUSIONS: It was shown that individual education with the MOATT and follow-up
for patients receiving oral agents for cancer treatment increased patient
medication adherence self-efficacy.
DOI: 10.4103/apjon.apjon_35_17
PMCID: PMC5559938
PMID: 28966956
Mills K(1), Birt L(1), Emery JD(2), Hall N(3), Banks J(4), Johnson M(1),
Lancaster J(1), Hamilton W(5), Rubin GP(3), Walter FM(1).
Author information:
(1)Department of Public Health and Primary Care, The Primary Care Unit,
University of Cambridge, Cambridge, UK.
(2)Department of General Practice, Primary Care Cancer Research, University of
Melbourne, Carlton, Victoria, Australia.
(3)Evaluation Research Development Unit, School of Medicine, Pharmacy & Health,
Durham University, Bristol, UK.
(4)Centre for Academic Primary Care, School of Social and Community Medicine,
University of Bristol, Bristol, UK.
(5)Department of Primary Care Diagnostics, College House, St Luke's Campus,
University of Exeter, Exeter, UK.
OBJECTIVE: Pancreatic cancer has poor survival rates due to non-specific symptoms
leading to later diagnosis. Understanding how patients interpret their symptoms
could inform approaches to earlier diagnosis. This study sought to explore
symptom appraisal and help-seeking among patients referred to secondary care for
symptoms suggestive of pancreatic cancer.
DESIGN: Qualitative analysis of semistructured in-depth interviews. Data were
analysed iteratively and thematically, informed by the Model of Pathways to
Treatment.
PARTICIPANTS AND SETTING: Pancreatic cancer occurs rarely in younger adults,
therefore patients aged ≥40 years were recruited from nine hospitals after being
referred to hospital with symptoms suggestive of pancreatic cancer; all were
participants in a cohort study. Interviews were conducted soon after referral,
and where possible, before diagnosis.
RESULTS: Twenty-six interviews were conducted (cancer n=13 (pancreas n=9, other
intra-abdominal n=4), non-cancer conditions n=13; age range 48-84 years; 14
women). Time from first symptoms to first presentation to healthcare ranged from
1 day to 270 days, median 21 days. We identified three main themes. Initial
symptom appraisal usually began with intermittent, non-specific symptoms such as
tiredness or appetite changes, attributed to diet and lifestyle, existing
gastrointestinal conditions or side effects of medication. Responses to initial
symptom appraisal included changes in meal type or frequency, or self-medication.
Symptom changes such as alterations in appetite and enjoyment of food or weight
loss usually prompted further appraisal. Triggers to seek help included a change
or worsening of symptoms, particularly pain, which was often a 'tipping point'.
Help-seeking was often encouraged by others. We found no differences in symptom
appraisal and help-seeking between people diagnosed with cancer and those with
other conditions.
CONCLUSIONS: Greater public and healthcare professional awareness of the
combinations of subtle and intermittent symptoms, and their evolving nature, is
needed to prompt timelier help-seeking and investigation among people with
symptoms of pancreatic cancer.
© Article author(s) (or their employer(s) unless otherwise stated in the text of
the article) 2017. All rights reserved. No commercial use is permitted unless
otherwise expressly granted.
DOI: 10.1136/bmjopen-2016-015682
PMCID: PMC5588944
PMID: 28871013 [Indexed for MEDLINE]
606. J Clin Nurs. 2017 Mar;26(5-6):586-598. doi: 10.1111/jocn.13588. Epub 2016 Nov
29.
Author information:
(1)Department of Science of Nursing Care, Indiana University School of Nursing,
Indianapolis, IN, USA.
DOI: 10.1111/jocn.13588
PMID: 27648739 [Indexed for MEDLINE]
Kawakami A(1)(2), Tanaka M(3), Nishigaki M(4), Yoshimura N(5), Suzuki R(6), Maeda
S(7), Kunisaki R(8), Yamamoto-Mitani N(9).
Author information:
(1)Inflammatory Bowel Disease Center, Yokohama City University Medical Center,
4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan.
akikawakami-tky@umin.ac.jp.
(2)Department of Gastroenterology, Yokohama City University Graduate School of
Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
akikawakami-tky@umin.ac.jp.
(3)Department of Advanced Clinical Nursing, Graduate School of Medicine, the
University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
hmakoto-tky@umin.ac.jp.
(4)Department of Adult Nursing, Graduate school of Medicine the University of
Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Japan. nishigaki-tky@umin.ac.jp.
(5)Department of Gastroenterology, Social Insurance Central General Hospital,
3-22-1 Hyakuninn-cho, Shinjyuku-ku, Tokyo, 169-0073, Japan. ynaokun@yahoo.co.jp.
(6)Kannai Suzuki Clinic, 3-28 Onoue-cho, Naka-ku, Yokohama, 231-0028, Japan.
kannaisuzuki@muse.ocn.ne.jp.
(7)Department of Gastroenterology, Yokohama City University Graduate School of
Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
smaeda@med.yokohama-cu.ac.jp.
(8)Inflammatory Bowel Disease Center, Yokohama City University Medical Center,
4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan.
reikok@urahp.yokohama-cu.ac.jp.
(9)Department of Adult Nursing, Graduate school of Medicine the University of
Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Japan. noriko-tky@umin.ac.jp.
DOI: 10.1186/s12876-014-0220-z
PMCID: PMC4279902
PMID: 25523298 [Indexed for MEDLINE]
Author information:
(1)Department of Pharmacy, Washington Regional Medical Center, Fayetteville,
Arkansas.
(2)Department of Pharmacy, The Children's Hospital at Saint Francis, Tulsa,
Oklahoma.
(3)Professor and Department Chair, Department of Pharmacy: Clinical and
Administrative Sciences-Tulsa, University of Oklahoma College of Pharmacy;
Department of Pediatrics, University of Oklahoma School of Community Medicine,
Tulsa, Oklahoma.
(4)University of Oklahoma College of Pharmacy, Oklahoma City, Oklahoma.
DOI: 10.5863/1551-6776-21.6.502
PMCID: PMC5178812
PMID: 28018152
Author information:
(1)Semnan Health Center, Semnan University of Medical Sciences, Semnan, Iran.
(2)Psychology Unit, School of Allied Medical Sciences, Semnan University of
Medical Sciences, Semnan, Iran.
(3)Nursing Care Research Center, Semnan University of Medical Sciences Semnan,
Semnan, Iran.
Introduction: This study was designed to determine self-efficacy and its related
factors in patients with hypertension.
Materials and methods: This study is descriptive-sectional from the correlation.
A total of 250 patients from a blood pressure clinic of Semnan city (in Iran)
completed Medication Understanding and Use Self-Efficacy Scale were randomly
selected in 2017. Data were analyzed using variance, Pearson's Correlation, and
χ2 using the LISREL 8.8 software.
Results: The items 1, 6, 7, and 8 have high correlation (at least higher than
0.60), indicating the possibility of aggregation of these four variables in the
first factor (taking medication), and the four items 2, 3, 4, and 5 are highly
correlated with each other, which are the second factor (learning about
medication). In addition, Cronbach's α of reliability (taking medication) for the
first factor was 0.67 and 0.63 for the second factor (learning about medication)
and 0.69 for the whole scale.
Conclusion: The effectiveness of blood pressure self-efficacy is an appropriate
tool for measure-taking responsibility for the time and taking medications by
patients, and researchers can use it as a valid tool in therapeutic,
psychological, and health research.
DOI: 10.1556/1646.10.2018.05
PMCID: PMC6167625
PMID: 30363355
610. Prim Care Companion CNS Disord. 2014 Dec 4;16(6). doi: 10.4088/PCC.14m01686.
eCollection 2014.
DOI: 10.4088/PCC.14m01686
PMCID: PMC4374825
PMID: 25834766
611. J Child Adolesc Psychopharmacol. 2016 Dec;26(10):864-872. Epub 2016 Jul 15.
Goldstein TR(1), Krantz M(1), Merranko J(1), Garcia M(1), Sobel L(1), Rodriguez
C(2), Douaihy A(1), Axelson D(3), Birmaher B(1).
Author information:
(1)1 Western Psychiatric Institute and Clinic, University of Pittsburgh Medical
Center , Pittsburgh, Pennsylvania.
(2)2 Hospital of Fuerteventura , Canary Health Service, Canary Islands, Spain .
(3)3 Nationwide Children's Hospital , Columbus, Ohio.
DOI: 10.1089/cap.2016.0030
PMCID: PMC5178003
PMID: 27419273 [Indexed for MEDLINE]
612. Pharmacy (Basel). 2018 Jul 26;6(3). pii: E77. doi: 10.3390/pharmacy6030077.
Author information:
(1)Department of Healthcare, Thomas More University College, 2500 Lier, Belgium.
toke.vanwesemael@uantwerpen.be.
(2)Department of Nursing Science and Midwifery, Centre For Research and
Innovation in Care (CRIC), Nurse and Pharmaceutical Care (NuPhac), Faculty of
Medicine and Health Sciences, University of Antwerp, 2610 Wilrijk, Belgium.
toke.vanwesemael@uantwerpen.be.
(3)Department of Healthcare, Thomas More University College, 2500 Lier, Belgium.
tinne.dilles@uantwerpen.be.
(4)Department of Nursing Science and Midwifery, Centre For Research and
Innovation in Care (CRIC), Nurse and Pharmaceutical Care (NuPhac), Faculty of
Medicine and Health Sciences, University of Antwerp, 2610 Wilrijk, Belgium.
tinne.dilles@uantwerpen.be.
(5)Department of Nursing Science and Midwifery, Centre For Research and
Innovation in Care (CRIC), Nurse and Pharmaceutical Care (NuPhac), Faculty of
Medicine and Health Sciences, University of Antwerp, 2610 Wilrijk, Belgium.
bart.vanrompaey@uantwerpen.be.
(6)Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent
University, 9000 Ghent, Belgium. koen.boussery@ugent.be.
DOI: 10.3390/pharmacy6030077
PMCID: PMC6164845
PMID: 30049965
Author information:
(1)Department of Psychology, Simon Fraser University, Burnaby, British Columbia,
Canada.
(2)Ben-Gurion University of the Negev, Beersheba, Israel.
(3)University of British Columbia, Vancouver, British Columbia, Canada.
DOI: 10.1371/journal.pone.0204219
PMCID: PMC6161882
PMID: 30265697 [Indexed for MEDLINE]
614. BMC Nurs. 2016 Feb 8;15:9. doi: 10.1186/s12912-016-0130-1. eCollection 2016.
Author information:
(1)Faculty of Nursing and Medical Care, Keio University, 35 Shinanomachi,
Shinjuku-ku, Tokyo 160-8582 Japan.
(2)Division of Biostatistics, Tohoku University Graduate School of Medicine, 1-1
Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574 Japan.
Erratum in
BMC Nurs. 2016 Oct 24;15:61.
DOI: 10.1186/s12912-016-0130-1
PMCID: PMC4745168
PMID: 26858582
El Alili M(1), Vrijens B(2)(3), Demonceau J(2), Evers SM(1)(4), Hiligsmann M(1).
Author information:
(1)Department of Health Services Research, CAPHRI School for Public Health and
Primary Care, Maastricht University, Maastricht, The Netherlands.
(2)WestRock Healthcare, Visé, Belgium.
(3)Department of Public Health, University of Liège, Liège, Belgium.
(4)Trimbos Institute of Mental Health and Addiction, Utrecht, The Netherlands.
DOI: 10.1111/bcp.12942
PMCID: PMC4917812
PMID: 27005306 [Indexed for MEDLINE]
Relationship Between Medication Adherence and Health Beliefs Among Patients with
Hypertension in Oman: Pilot study.
Al-Noumani H(1), Wu JR(2), Barksdale D(3), Alkhasawneh E(4), Knafl G(2), Sherwood
G(2).
Author information:
(1)Departments of Adult Health & Critical Care, College of Nursing, Sultan Qaboos
University, Muscat, Oman.
(2)Department of Adult Health, School of Nursing, University of North Carolina,
Chapel Hill, North Carolina, USA.
(3)Associate Dean of Academic Affairs, School of Nursing, Virginia Commonwealth
University, Richmond, Virginia, USA.
(4)Maternal & Child Health, College of Nursing, Sultan Qaboos University, Muscat,
Oman.
DOI: 10.18295/squmj.2017.17.03.012
PMCID: PMC5642364
PMID: 29062557 [Indexed for MEDLINE]
Appalasamy JR(1), Tha KK(1), Quek KF(1), Ramaiah SS(2), Joseph JP(3), Md Zain
AZ(1).
Author information:
(1)Jeffrey Cheah School of Medicine and Health Sciences, Monash University
Malaysia.
(2)Subang Jaya Medical Centre, Jalan SS12/1a, Selangor.
(3)Neurology Department, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
DOI: 10.1097/MD.0000000000010876
PMCID: PMC6393048
PMID: 29851804 [Indexed for MEDLINE]
Shi S(1)(2), Shen Z(1), Duan Y(1), Ding S(1)(2), Zhong Z(1)(2).
Author information:
(1)Nursing Department, Third Xiangya Hospital, Central South University,
Changsha, China.
(2)Xiangya School of Nursing, Central South University, Changsha, China.
DOI: 10.3389/fphar.2019.00822
PMCID: PMC6664237
PMID: 31396088
Author information:
(1)Faculty of Medicine.
(2)Faculty of Pharmaceutical Sciences, University of British Columbia.
(3)Department of Pharmacy, Children's and Women's Health Centre of British
Columbia.
(4)Department of Medicine, Division of Respiratory Medicine, University of
British Columbia.
(5)Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada.
DOI: 10.2147/PPA.S129088
PMCID: PMC5383089
PMID: 28408806
Author information:
(1)Institute of Communication and Health, Università della Svizzera italiana,
Lugano, Switzerland.
DOI: 10.1371/journal.pone.0186458
PMCID: PMC5645121
PMID: 29040335 [Indexed for MEDLINE]
621. Int J Pharm Pract. 2017 Jun;25(3):185-194. doi: 10.1111/ijpp.12242. Epub 2016
Feb
1.
Author information:
(1)e-Health Research Group, Centre for Population Health Sciences, University of
Edinburgh, Edinburgh, UK.
(2)NHS Lothian Pharmacy Service, Western General Hospital, Edinburgh, UK.
(3)Centre for Academic Primary Care, Polwarth Building West Block, Aberdeen, UK.
(4)Edinburgh Health Services Research Unit, University of Edinburgh, Edinburgh,
UK.
DOI: 10.1111/ijpp.12242
PMID: 26833669 [Indexed for MEDLINE]
Author information:
(1)Department of Computer and Information Sciences, Covenant University, Nigeria.
(2)International Center for IT and Development, Southern University and A&M,
Baton Rouge, LA, USA.
Medication adherence still ranks as a big challenge for clinicians and health
workers. Based on a social learning theoretical framework, this study explores
the adoption of patient adherence, medication adherence as a catalyst for
improving the health and quality of life of individuals in Nigeria. Structural
Equation Modelling technique was used to analyze the empirical data obtained. SLT
variables including self-efficacy and outcome expectation were tested against
medication adherence behavior. The constructs are related and positively
correlated except definition which is contrary to previous researches. The
research discusses these findings while also highlighting the implications for
practice and policy.
DOI: 10.4081/jphia.2018.826
PMCID: PMC6379697
PMID: 30854176
DOI: 10.3399/bjgp16X685609
PMCID: PMC4979933
PMID: 27215572 [Indexed for MEDLINE]
624. Pharmacy (Basel). 2019 Jun 28;7(3). pii: E76. doi: 10.3390/pharmacy7030076.
Author information:
(1)Department of Pharmacy Practice and Science, University of Iowa College of
Pharmacy, Iowa City, IA 52242, USA. matthew-witry@uiowa.edu.
(2)Mercy Family Pharmacy, Dubuque, IA 52001, USA.
(3)Department of Pharmacy Practice and Science, University of Iowa College of
Pharmacy, Iowa City, IA 52242, USA.
DOI: 10.3390/pharmacy7030076
PMID: 31261613
Yu ZL(1), Lee VY(1), Kang AW(1), Chan S(2), Foo M(3), Chan CM(3), Griva K(1)(4).
Author information:
(1)Department of Psychology, National University of Singapore, Singapore,
Singapore.
(2)Alice Lee Centre for Nursing Studies, National University Hospital, Singapore,
Singapore.
(3)Department of Renal Medicine, Singapore General Hospital, Singapore,
Singapore.
(4)Health Services Research Group, City University London, London, United
Kingdom.
DOI: 10.1371/journal.pone.0149784
PMCID: PMC4769138
PMID: 26919323 [Indexed for MEDLINE]
Author information:
(1)Scientific Insights Consulting Group Inc., Mississauga, ON, Canada.
(2)University of Toronto Mississauga, Mississauga, ON, Canada.
(3)Truman Medical Centre, Kansas City, MO, USA; Department of Community & Family
Medicine, University of Missouri-Kansas City, Kansas City, MO, USA.
(4)ConscienHealth, Pittsburgh, PA, USA.
DOI: 10.1177/2050312115595822
PMCID: PMC4679322
PMID: 26770793
Sutton SK(1)(2), Van Rensburg KJ(3), Jentink KG(4), Drobes DJ(1)(3)(5), Evans
DE(6)(7)(8).
Author information:
(1)Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa,
FL, USA.
(2)Department of Psychology, University of South Florida, Tampa, FL, USA.
(3)Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL,
USA.
(4)Department of Psychology, Colorado State University, Fort Collins, CO, USA.
(5)Department of Oncologic Sciences, University of South Florida, 4115 E Fowler
Ave., Tampa, FL, 33617, USA.
(6)Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa,
FL, USA. david.evans@moffitt.org.
(7)Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL,
USA. david.evans@moffitt.org.
(8)Department of Oncologic Sciences, University of South Florida, 4115 E Fowler
Ave., Tampa, FL, 33617, USA. david.evans@moffitt.org.
DOI: 10.1007/s00213-016-4276-z
PMCID: PMC6036628
PMID: 27044353 [Indexed for MEDLINE]
Author information:
(1)Philips Research, Briarcliff Manor, NY, United States. rony.calo@philips.com.
DOI: 10.2196/resprot.4282
PMCID: PMC4527006
PMID: 26195072
Author information:
(1)Boston University, Department of Medicine, 72 E Concord St, Boston, MA 02118.
Email: caallen89@gmail.com.
(2)Emory University, Rollins School of Public Health, Atlanta, Georgia.
DOI: 10.5888/pcd13.160236
PMCID: PMC5201147
PMID: 28033090 [Indexed for MEDLINE]
Author information:
(1)School of Nursing, University of Jember, Indonesia.
(2)School of Engineering, University of Jember, Indonesia.
(3)Department of Medical and Surgical Nursing, School of Nursing, University of
Jember, Indonesia.
(4)Department of Family and Community Health Nursing, School of Nursing,
University of Jember, Indonesia.
631. New Microbes New Infect. 2015 Apr 16;6:22-9. doi: 10.1016/j.nmni.2015.02.007.
eCollection 2015 Jul.
Roca I(1), Akova M(2), Baquero F(3), Carlet J(4), Cavaleri M(5), Coenen S(6),
Cohen J(7), Findlay D(8), Gyssens I(9), Heuer OE(10), Kahlmeter G(11), Kruse
H(12), Laxminarayan R(13), Liébana E(14), López-Cerero L(15), MacGowan A(16),
Martins M(17), Rodríguez-Baño J(18), Rolain JM(19), Segovia C(20), Sigauque
B(21), Tacconelli E(22), Wellington E(23), Vila J(24).
Author information:
(1)ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital
Clínic-Universitat de Barcelona, Barcelona, Spain.
(2)Department of Medicine, Section of Infectious Diseases, Hacettepe University
School of Medicine, Ankara, Turkey ; ESCMID Executive Committee, Basel,
Switzerland.
(3)Department of Microbiology at the Ramón y Cajal University Hospital, Ramón y
Cajal Institute for Health Research (IRYCIS), Division for Research in Microbial
Biology and Evolution, CIBERESP, Madrid, Spain.
(4)Fondation Hôpital St, Joseph, Paris, France and World Alliance Against
Antibiotic Resistance (WAAAR), Creteil, France.
(5)European Medicines Agency (EMA), London, UK.
(6)Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute
(VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp,
Antwerp, Belgium.
(7)Brighton and Sussex Medical School, Brighton, UK.
(8)Global Commercial Lead, GlaxoSmithKline (GSK), London, UK.
(9)Department of Medicine, Radboud University Medical Center and Department of
Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital,
Nijmegen, The Netherlands.
(10)European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
(11)Clinical Microbiology, Central Hospital, Växjö, Sweden ; ESCMID Executive
Committee, Basel, Switzerland ; EUCAST Steering Committee, Växjö, Sweden.
(12)WHO Regional Office for Europe, UN City, Marmorvej, Copenhagen, Denmark.
(13)Center for Disease Dynamics, Economics and Policy, Washington, DC, USA ;
Princeton University, Princeton, NJ, USA.
(14)Scientific Unit on Biological Hazards, European Food Safety Authority (EFSA),
Parma, Italy.
(15)Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital
Universitario Virgen Macarena, Seville, Spain.
(16)Department of Medical Microbiology, Southmead Hospital, Bristol, UK ; EUCAST
Steering Committee, Växjö, Sweden.
(17)School of Public Health, Physiotherapy and Population Science, UCD Centre for
Food and Safety, Molecular Innovation and Drug Discovery, University College
Dublin, Dublin, Ireland.
(18)Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital
Universitario Virgen Macarena, and Departamento de Medicina, Universidad de
Sevilla, Seville, Spain ; ESCMID Executive Committee, Basel, Switzerland.
(19)Aix-Marseille Université, Unité de Recherche en Maladies Infectieuses et
Tropicales Emergentes (URMITE), Inserm, IHU Méditerranée Infection, Faculté de
Médecine et de Pharmacie, and APHM, CHU Timone, Pôle Infectieux, Marseille,
France.
(20)Instituto de Salud Carlos III, ISCIII, Madrid, Spain.
(21)Centro de Investigação em Saúde da Manhiça and Instituto Nacional de
Saúde/Ministério de Saúde, Maputo, Mozambique.
(22)Division of Infectious Diseases, Department of Internal Medicine I, Tübingen
University Hospital, Tübingen, Germany ; ESCMID Executive Committee, Basel,
Switzerland.
(23)School of Life Sciences, University of Warwick, Coventry, UK.
(24)ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital
Clínic-Universitat de Barcelona, Barcelona, Spain ; ESCMID Executive Committee,
Basel, Switzerland.
Erratum in
New Microbes New Infect. 2015 Nov;8:175.
In the last decade we have witnessed a dramatic increase in the proportion and
absolute number of bacterial pathogens resistant to multiple antibacterial
agents. Multidrug-resistant bacteria are currently considered as an emergent
global disease and a major public health problem. The B-Debate meeting brought
together renowned experts representing the main stakeholders (i.e. policy makers,
public health authorities, regulatory agencies, pharmaceutical companies and the
scientific community at large) to review the global threat of antibiotic
resistance and come up with a coordinated set of strategies to fight
antimicrobial resistance in a multifaceted approach. We summarize the views of
the B-Debate participants regarding the current situation of antimicrobial
resistance in animals and the food chain, within the community and the healthcare
setting as well as the role of the environment and the development of novel
diagnostic and therapeutic strategies, providing expert recommendations to tackle
the global threat of antimicrobial resistance.
DOI: 10.1016/j.nmni.2015.02.007
PMCID: PMC4446399
PMID: 26029375
Kimmick G(1), Edmond SN(2), Bosworth HB(3), Peppercorn J(4), Marcom PK(4),
Blackwell K(4), Keefe FJ(2), Shelby RA(2).
Author information:
(1)Duke Cancer Institute, Duke University Medical Center, DUMC Box 3204, Durham,
NC 27710, USA. Electronic address: gretchen.kimmick@duke.edu.
(2)Department of Psychiatry and Behavioral Sciences, Duke University Medical
Center, USA.
(3)Department of Medicine, Psychiatry, and School of Nursing, Duke University
Medical Center; Center for Health Services Research, Durham VAMC, USA.
(4)Duke Cancer Institute, Duke University Medical Center, DUMC Box 3204, Durham,
NC 27710, USA.
DOI: 10.1016/j.breast.2015.06.010
PMCID: PMC4824055
PMID: 26189978 [Indexed for MEDLINE]
Author information:
(1)School of Pharmacy and Pharmacology, Gold Coast Campus, Griffith University,
Queensland 4222, Australia and Menzies Health Institute Queensland, Gold Coast
Campus, Griffith University, Queensland, Australia.
OBJECTIVE: To measure the impact of the multidisciplinary Turning Pain Into Gain
program in people experiencing chronic pain of any etiology.
METHODS: A mixed-methods observational study of 252 participants was used to
explore the impact of Turning Pain Into Gain on medication use; quality of life
and functioning, as measured by the Pain Self-Efficacy Questionnaire; and
self-reported hospitalizations between 2015 and 2016.
RESULTS: Responses from 178 participants showed an increased alignment with
Australian pain medication guidelines (e.g., a 7.3% reduction in paracetamol
duplication was reported with a concurrent 5.1% rise in the administration of
sustained-release paracetamol formulations); improved Pain Self-Efficacy
Questionnaire scores from 23.1 (out of a possible score of 60) preprogram to 35.3
postprogram; and a reduction in self-reported hospitalizations from 50 cases in
the 12 months preprogram to 11 cases in the 12 months postprogram.
CONCLUSIONS: Positive medication, Pain Self-Efficacy Questionnaire, and
hospitalization changes provide evidence for the broader implementation of
similar patient-centered programs to promote more holistic management of diverse
types of chronic pain in primary care. Reduced hospitalization reflects potential
for this intervention to be cost-effective, which could be investigated further.
DOI: 10.1093/pm/pny241
PMCID: PMC6497132
PMID: 30541054
Huang Z(1)(2), Lum E(3)(4)(5), Jimenez G(3), Semwal M(3), Sloot P(6)(7)(8), Car
J(3).
Author information:
(1)Centre for Population Health Sciences, Lee Kong Chian School of Medicine,
Nanyang Technological University, Clinical Sciences Building, Level 18, 11
Mandalay Road, Singapore, 308232, Singapore. ZHUANG014@e.ntu.edu.sg.
(2)NTU Institute for Health Technologies (HealthTech NTU), Interdisciplinary
Disciplinary School, Nanyang Technological University, Singapore, Singapore.
ZHUANG014@e.ntu.edu.sg.
(3)Centre for Population Health Sciences, Lee Kong Chian School of Medicine,
Nanyang Technological University, Clinical Sciences Building, Level 18, 11
Mandalay Road, Singapore, 308232, Singapore.
(4)Institute of Health and Biomedical Innovation, Queensland University of
Technology, Brisbane, Australia.
(5)School of Clinical Sciences, Faculty of Health, Queensland University of
Technology, Brisbane, Australia.
(6)Institute for Advanced Study, University of Amsterdam, Amsterdam, The
Netherlands.
(7)ITMO University, Saint Petersburg, Russia.
(8)Complexity Institute, Nanyang Technological University, Singapore, Singapore.
DOI: 10.1186/s12916-019-1362-1
PMCID: PMC6636047
PMID: 31311573
McRae-Clark AL(1), Baker NL(2), Sonne SC(3), DeVane CL(3), Wagner A(3), Norton
J(3).
Author information:
(1)Department of Psychiatry, Medical University of South Carolina, Charleston, SC
29425. Electronic address: mcraeal@musc.edu.
(2)Department of Public Health Sciences, Medical University of South Carolina,
Charleston, SC 29425.
(3)Department of Psychiatry, Medical University of South Carolina, Charleston, SC
29425.
DOI: 10.1016/j.jsat.2015.05.002
PMCID: PMC4561011
PMID: 26028133 [Indexed for MEDLINE]
Author information:
(1)School of Nursing, The University of North Carolina at Charlotte, Charlotte,
NC, USA.
(2)Internal Medicine, Novant Health First Charlotte Physicians, Matthews, NC,
USA.
(3)School of Nursing, The University of Texas at Tyler, Tyler, TX, USA.
BACKGROUND: Black women in the USA have the highest prevalence rate of
hypertension (HTN) contributing to a higher risk of organ damage and death.
Research has focused primarily on poorly controlled HTN, negative belief systems,
and nonadherence factors that hinder blood pressure control. No known research
studies underscore predominantly Black women who report consistent adherence to
their antihypertensive medication-taking. The purpose of this study was to
describe self-care management strategies used by Black women who self-report
consistent adherence to their antihypertensive medication and to determine the
existence of further participation in lifestyle modifications, such as eating a
healthy diet and increasing physical activity.
METHODS: Using a qualitative descriptive design, four focus groups with a total
of 20 Black women aged 25-71 years were audio-taped. Transcripts were analyzed
using qualitative content analysis. Participants were included in the study if
they scored perfect adherence on the medication subscale of the Hill-Bone
Compliance to High Blood Pressure Therapy Scale.
RESULTS: Medication adherence was predicated on three themes: HTN experience,
involvement with treatment regimen, and a strong motivated mentality. Black women
would benefit from treatment approaches that are sensitive to 1) diverse
emotional responses, knowledge levels, and life experiences; 2) two-way
communication and trusting, collaborative relationships with active involvement
in the treatment regimen; 3) lifestyle modifications that focus on health
benefits and individual preferences; and 4) spiritual/religious influences on
adherence.
CONCLUSION: The use of self-care management strategies to enhance
antihypertensive medication adherence is key to adequate blood pressure control
and the reduction of cardiovascular events. This study provides preliminary
insight for future research to develop interventions to aid those Black women who
struggle with medication adherence and are disproportionately impacted by HTN.
DOI: 10.2147/PPA.S138162
PMCID: PMC5565386
PMID: 28860723
BACKGROUND: It has been reported that stroke has a higher incidence and mortality
rate in the People's Republic of China compared to the global average. These
conditions can be managed by proper medication use, but ensuring medication
adherence is challenging.
OBJECTIVE: To translate the Self-Efficacy for Appropriate Medication Use Scale
into Chinese and test its validity and reliability in patients with stroke.
METHODS: Instrument performances were measured from January 15, 2015 to April 28,
2015 on a convenience sample of 400 patients with stroke recruited at four
neurology departments of the First Affiliated Hospital of Zhengzhou University.
Questionnaires included the Chinese versions of the Self-Efficacy for Appropriate
Medication Use Scale (C-SEAMS) and the General Self-Efficacy Scale (C-GSE).
Construct validity, convergent validity, internal consistency, and test-retest
reliability were measured.
RESULTS: Item analysis showed that item-to-total correlations were in the range
of 0.362-0.672. Exploratory factor analysis revealed two factors (which accounted
for 60.862% of total variance), with factor loading ranging from 0.534 to 0.756.
Confirmatory factor analysis was performed to support the results, with an
acceptable fit (χ (2)=73.716; df=64; P<0.01; goodness-of-fit index =0.902;
adjusted goodness-of-fit index =0.897; comparative fit index =0.865;
root-mean-square error of approximation =0.058). The convergent validity of the
C-SEAMS correlated well with the validated measure of the C-GSE in measuring
self-efficacy (r=0.531, P<0.01). Good internal consistency (Cronbach's alpha
ranged from 0.826 to 0.915) and test-retest reliability (Pearson's correlation
coefficient r=0.642, P<0.01) were found.
CONCLUSION: The C-SEAMS is a brief and psychometrically sound measure for
evaluating self-efficacy for medication adherence in the Chinese population with
stroke.
DOI: 10.2147/PPA.S101844
PMCID: PMC4798205
PMID: 27042023
Rhee H(1), Wicks MN(2), Dolgoff JS(2), Love TM(3), Harrington D(3).
Author information:
(1)University of Rochester School of Nursing, Rochester, NY, USA.
(2)College of Nursing, University of Tennessee Health Science Center, Memphis,
TN, USA.
(3)Department of Biostatistics and Computational Biology, University of Rochester
Medical Center, Rochester, NY, USA.
Purpose: Adolescents with asthma often report poor medication adherence and
asthma control. Cognitive factors embedded in the social cognitive theory
including self-efficacy, outcome expectations, and barrier perceptions may
explain poor asthma outcomes in this population. This study was performed to
examine the extent to which these cognitive factors are intercorrelated and
explain medication adherence and asthma control in urban adolescents.
Patients and methods: A total of 373 urban adolescents (12-20 years) with asthma
completed questionnaires measuring asthma-related self-efficacy, outcome
expectations, barrier perceptions, medication adherence, and asthma control.
Multiple linear regression was conducted to examine the extent to which the three
cognitive factors predicted medication adherence and asthma control after
controlling for covariates including age, sex, household income, and age at
diagnosis.
Results: Participants' ages were on average 14.68 (±1.94) years; 50% were female,
and most (78.6%) were African American. Higher self-efficacy associated with
lower barrier perceptions and higher outcome expectations (r=0.50, p<0.001;
r=-0.26, p<0.001, respectively). Self-efficacy predicted better asthma control
(B=-0.098, p=0.004) and adherence (B=0.426, p=0.011), whereas barrier perceptions
predicted poorer asthma control (B=0.13, p<0.001) and adherence (B=-0.568,
p<0.001). Self-efficacy independently predicted fewer missed doses (B=-0.621,
p=0.006), and barrier perception independently predicted asthma control (B=0.12,
p<0.001) and adherence (B=-0.519, p<0.001).
Conclusion: Improving medication adherence and asthma control among adolescents
may require a multifaceted approach. Interventions focused on increasing
self-efficacy and addressing barriers, actual or potential, to medication
adherence could ameliorate asthma disparities in urban adolescents.
DOI: 10.2147/PPA.S162925
PMCID: PMC5973469
PMID: 29872278
Author information:
(1)Department of Medicine, University of Rochester Medical Center, Rochester, NY,
USA.
(2)Houston Methodist DeBakey Heart and Vascular Center, Houston, TX, USA.
(3)Section of Heart Failure and Cardiac Transplantation, Tomsich Family
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland
Clinic, Cleveland, OH, USA.
(4)Center for Connected Care, Cleveland Clinic, Cleveland, OH, USA.
DOI: 10.1177/2050312117700301
PMCID: PMC5433792
PMID: 28540048
Author information:
(1)Department of Preventive Medicine, Feinberg School of Medicine, Northwestern
University, Chicago, IL, USA.
(2)Department of Population Health Sciences, University of Wisconsin at Madison,
Madison, WI, USA.
DOI: 10.1038/jhh.2016.80
PMCID: PMC6062205
PMID: 27853149 [Indexed for MEDLINE]
Crowley MJ(1), Zullig LL, Shah BR, Shaw RJ, Lindquist JH, Peterson ED, Bosworth
HB.
Author information:
(1)Center for Health Services Research in Primary Care, Durham VA Medical Center,
HSR&D (152), 508 Fulton Street, Durham, NC, 27705, USA,
matthew.crowley@dm.duke.edu.
Author information:
(1)(Corresponding author) PharmD Candidate 2018, North Dakota State University,
School of Pharmacy, Fargo, North Dakota, n_erik@hotmail.com.
(2)Faculty Mentor, Associate Professor of Practice, North Dakota State
University, School of Pharmacy, Fargo, North Dakota.
(3)Associate Professor of Sociology, North Dakota State University, School of
Sociology and Anthropology, Fargo, North Dakota.
(4)Associate Professor of Practice, North Dakota State University, School of
Pharmacy, Fargo, North Dakota.
DOI: 10.9740/mhc.2018.09.214
PMCID: PMC6125114
PMID: 30206504
Ugwu E(1), Adeleye O(2), Gezawa I(3), Okpe I(4), Enamino M(5), Ezeani I(6).
Author information:
(1)Department of Medicine, Enugu State University of Science and Technology
Enugu, Enugu 400001, Nigeria. ofornet@yahoo.com.
(2)Department of Medicine, Lagos State University Lagos, Lagos 100001, Nigeria.
(3)Department of Medicine, Bayero University Kano, Kano 700001, Nigeria.
(4)Department of Medicine, Ahmadu Bello University Zaria, Kaduna 800001, Nigeria.
(5)Department of Medicine, Federal Medical Center Keffi, Nasarawa 961101,
Nigeria.
(6)Department of Medicine, Federal Medical Center Umuahia, Abia 440001, Nigeria.
DOI: 10.4239/wjd.v10.i3.200
PMCID: PMC6422858
PMID: 30891155
644. BMC Complement Altern Med. 2018 Feb 15;18(1):62. doi: 10.1186/s12906-018-2129-
5.
Traditional healing practices in rural Bangladesh: a qualitative investigation.
Author information:
(1)Department of Public Health, Daffodil International University, 102 & 102/1
Shukrabad, Mirpur Road, Dhanmondi, Dhaka, 1207, Bangladesh.
imdadul.ph@diu.edu.bd.
(2)Health, Nutrition and Population Program, BRAC, Mirpur, Dhaka, 1216,
Bangladesh. imdadul.ph@diu.edu.bd.
(3)Department of Public Health, Daffodil International University, 102 & 102/1
Shukrabad, Mirpur Road, Dhanmondi, Dhaka, 1207, Bangladesh.
DOI: 10.1186/s12906-018-2129-5
PMCID: PMC5815193
PMID: 29448941 [Indexed for MEDLINE]
Author information:
(1)Department of Neurobiology and Behavior, University of California, Irvine, CA
92697-4550, USA; Department of Neurophysiology, Yamagata University School of
Medicine, Yamagata 990-9585, Japan.
(2)Department of Neurobiology and Behavior, University of California, Irvine, CA
92697-4550, USA. Electronic address: ksumikaw@uci.edu.
A high rate of heavy tobacco smoking among people with schizophrenia has been
suggested to reflect self-medication and amelioration of cognitive dysfunction, a
core feature of schizophrenia. NMDAR hypofunction is hypothesized to be a
mechanism of cognitive dysfunction, and excessive schizophrenia-linked neuregulin
1 (NRG1) signaling through its receptor ErbB4 can suppress NMDAR function by
preventing Src-mediated enhancement of NMDAR responses. Here we investigated
whether chronic nicotine exposure in rats by subcutaneous injection of nicotine
(0.5-1 mg/kg, twice daily for 10-15 days) counteracts the suppressive effect of
NRG1β on NMDAR-mediated responses recorded from CA1 pyramidal cells in acute
hippocampal slices. We found that NRG1β, which prevents the enhancement of NMDAR
responses by the Src-family-kinase-activating peptide pYEEI in naive rats, failed
to block the effect of pYEEI in nicotine-exposed rats. In naive rats, NRG1β acts
only on GluN2B-NMDARs by blocking their Src-mediated upregulation. Chronic
nicotine exposure causes enhanced GluN2B-NMDAR responses via Src upregulation and
recruits Fyn for the enhancement of GluN2A-NMDAR responses. NRG1β has no effect
on both enhanced basal GluN2B-NMDAR responses and Fyn-mediated enhancement of
GluN2A-NMDAR responses. Src-mediated enhancement of GluN2B-NMDAR responses and
Fyn-mediated enhancement of GluN2A-NMDAR responses initiate long-term
potentiation (LTP) of AMPAR synaptic responses in naive and nicotine-exposed CA1
pyramidal cells, respectively. These results suggest that NRG1β suppresses LTP by
blocking Src-mediated enhancement of GluN2B-NMDAR responses, but has no effect on
LTP in nicotine-exposed rats. These effects of chronic nicotine exposure may
counteract the negative effect of increased NRG1-ErbB4 signaling on the cellular
mechanisms of learning and memory in individuals with schizophrenia, and
therefore may motivate heavy smoking.
DOI: 10.1016/j.neuropharm.2016.10.021
PMCID: PMC5148721
PMID: 27784625 [Indexed for MEDLINE]
Author information:
(1)Waggoner Center for Alcohol and Addiction Research, The University of Texas at
Austin, Austin, Texas 78712, USA.
(2)Center for Learning and Memory, The University of Texas at Austin, Austin,
Texas 78712, USA.
(3)Institute of Cell and Molecular Biology, The University of Texas at Austin,
Austin, Texas 78712, USA.
(4)Department of Neuroscience, The University of Texas at Austin, Austin, Texas
78712, USA.
(5)Department of Physiology and Pharmacology, Wake Forest University School of
Medicine, Winston-Salem, North Carolina 27101, USA.
Alcohol promotes lasting neuroadaptive changes that may provide relief from
depressive symptoms, often referred to as the self-medication hypothesis.
However, the molecular/synaptic pathways that are shared by alcohol and
antidepressants are unknown. In the current study, acute exposure to ethanol
produced lasting antidepressant and anxiolytic behaviours. To understand the
functional basis of these behaviours, we examined a molecular pathway that is
activated by rapid antidepressants. Ethanol, like rapid antidepressants, alters
γ-aminobutyric acid type B receptor (GABABR) expression and signalling, to
increase dendritic calcium. Furthermore, new GABABRs are synthesized in response
to ethanol treatment, requiring fragile-X mental retardation protein (FMRP).
Ethanol-dependent changes in GABABR expression, dendritic signalling, and
antidepressant efficacy are absent in Fmr1-knockout (KO) mice. These findings
indicate that FMRP is an important regulator of protein synthesis following
alcohol exposure, providing a molecular basis for the antidepressant efficacy of
acute ethanol exposure.
DOI: 10.1038/ncomms12867
PMCID: PMC5052688
PMID: 27666021
European Code against Cancer 4th Edition: Medical exposures, including hormone
therapy, and cancer.
Friis S(1), Kesminiene A(2), Espina C(2), Auvinen A(3), Straif K(2), Schüz J(4).
Author information:
(1)Danish Cancer Society Research Center, Danish Cancer Society,
Strandboulevarden 49, 2100 Copenhagen, Denmark; Department of Public Health,
University of Copenhagen, 2100 Copenhagen, and Department of Clinical
Epidemiology, Faculty of Health, Aarhus University Hospital, 8200 Aarhus N,
Denmark.
(2)International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas,
69372 Lyon, France.
(3)School of Health Sciences, University of Tampere, FI-33014 Tampere, Finland;
STUK-Radiation and Nuclear Safety Authority, Research and Environmental
Surveillance, FI-00881 Helsinki, Finland.
(4)International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas,
69372 Lyon, France. Electronic address: secretariat-cancer-code-europe@iarc.fr.
The 4th edition of the European Code against Cancer recommends limiting - or
avoiding when possible - the use of hormone replacement therapy (HRT) because of
the increased risk of cancer, nevertheless acknowledging that prescription of HRT
may be indicated under certain medical conditions. Current evidence shows that
HRT, generally prescribed as menopausal hormone therapy, is associated with an
increased risk of cancers of the breast, endometrium, and ovary, with the risk
pattern depending on factors such as the type of therapy (oestrogen-only or
combined oestrogen-progestogen), duration of treatment, and initiation according
to the time of menopause. Carcinogenicity has also been established for
anti-neoplastic agents used in cancer therapy, immunosuppressants,
oestrogen-progestogen contraceptives, and tamoxifen. Medical use of ionising
radiation, an established carcinogen, can provide major health benefits; however,
prudent practices need to be in place, with procedures and techniques providing
the needed diagnostic information or therapeutic gain with the lowest possible
radiation exposure. For pharmaceutical drugs and medical radiation exposure with
convincing evidence on their carcinogenicity, health benefits have to be balanced
against the risks; potential increases in long-term cancer risk should be
considered in the context of the often substantial and immediate health benefits
from diagnosis and/or treatment. Thus, apart from HRT, no general recommendations
on reducing cancer risk were given for carcinogenic drugs and medical radiation
in the 4th edition of European Code against Cancer. It is crucial that the
application of these measures relies on medical expertise and thorough
benefit-risk evaluation. This also pertains to cancer-preventive drugs, and
self-medication with aspirin or other potential chemopreventive drugs is strongly
discouraged because of the possibility of serious, potentially lethal, adverse
events.
DOI: 10.1016/j.canep.2015.08.003
PMID: 26390952 [Indexed for MEDLINE]
Awasthi S(1), Nichter M(2), Verma T(1), Srivastava NM(3), Agarwal M(4), Singh
JV(4); CAP-Lucknow Team.
Collaborators: Mishra AP, Sami G, Sharma RD, Khare R, Verma V, Pandey M, Shukla
V, Kumar S, Chandra A, Hasib-ur-Rehman, Pandey S.
Author information:
(1)Department of Pediatrics, King George's Medical University, Lucknow, India.
(2)The School of Anthropology, University of Arizona, Tucson, United States of
America.
(3)UNICEF's Office for Uttar Pradesh, Lucknow, India.
(4)Department of Community Medicine, King George's Medical University, Lucknow,
India.
DOI: 10.1371/journal.pone.0123135
PMCID: PMC4405201
PMID: 25898211 [Indexed for MEDLINE]
Prast JM(1), Schardl A(1), Sartori SB(2), Singewald N(2), Saria A(1), Zernig
G(3).
Author information:
(1)Department of General Psychiatry and Psychiatry, Experimental Psychiatry Unit,
Medical University of Innsbruck Innsbruck, Austria.
(2)Department of Pharmacology and Toxicology, Institute of Pharmacy and Center
for Molecular Biosciences Innsbruck, University of Innsbruck Innsbruck, Austria.
(3)Department of General Psychiatry and Psychiatry, Experimental Psychiatry Unit,
Medical University of Innsbruck Innsbruck, Austria ; Department of Psychology,
University of Innsbruck Innsbruck, Austria.
Anxiety disorders and substance use disorders are strongly associated in humans.
Accordingly, a widely held but controversial concept in the addiction field, the
so-called "self-medication hypothesis," posits that anxious individuals are more
vulnerable for drug dependence because they use drugs of abuse to alleviate their
anxiety. We tested this hypothesis under controlled experimental conditions by
quantifying the conditioned place preference (CPP) to 15 mg/kg i.p. cocaine given
contingently (COCAINE) in CD1 mice selectively bred for high anxiety-related
behavior (HAB) vs. normal anxiety-related behavior (NAB). Cocaine was conditioned
to the initially non-preferred compartment in an alternate day design (cocaine
vs. saline, four pairings each). HAB and NAB mice were also tested for the
effects of non-contingent (NONCONT) cocaine administration. HAB mice showed a
slightly higher bias for one of the conditioning compartments during the pretest
than NAB mice that became statistically significant (p = 0.045) only after
pooling COCAINE and NONCONT groups. Cocaine CPP was higher (p = 0.0035) in HAB
compared to NAB mice. The increased cocaine CPP was associated with an increased
expression of the immediate early genes (IEGs) c-Fos and Early Growth Related
Protein 1 (EGR1) in the accumbens corridor, i.e., a region stretching from the
anterior commissure to the interhemispheric border and comprising the medial
nucleus accumbens core and shell, the major island of Calleja and intermediate
part of the lateral septum, as well as the vertical limb of the diagonal band and
medial septum. The cocaine CPP-induced EGR1 expression was only observed in D1-
and D2-medium spiny neurons, whereas other types of neurons or glial cells were
not involved. With respect to the activation by contingent vs. non-contingent
cocaine EGR1 seemed to be a more sensitive marker than c-Fos. Our findings
suggest that cocaine may be more rewarding in high anxiety individuals, plausibly
due to an anxiolytic effect.
DOI: 10.3389/fnbeh.2014.00441
PMCID: PMC4273636
PMID: 25566008
Author information:
(1)Krefting Research Centre, Institute of Medicine, Internal Medicine and
Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Box 424,
SE-405 30 Gothenburg, Sweden ; Department of Care Science, Faculty of Health and
Society, Malmö University, Jan Waldenströms gata 25, SE-205 06 Malmö, Sweden.
(2)Krefting Research Centre, Institute of Medicine, Internal Medicine and
Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Box 424,
SE-405 30 Gothenburg, Sweden.
DOI: 10.1186/s40248-016-0078-8
PMCID: PMC5137217
PMID: 27980735
Qin P(1), Sun S(2), Bøe AS(3), Stanley B(3)(4), Mehlum L(3).
Author information:
(1)National Centre for Suicide Research and Prevention, Institute of Clinical
medicine, University of Oslo, Sognsvannsveien 21, N-0372, Oslo, Norway.
ping.qin@medisin.uio.no.
(2)Department of Epidemiology, Shandong University School of Public Health and
Shandong University Center for Suicide Prevention Research, Jinan, China.
(3)National Centre for Suicide Research and Prevention, Institute of Clinical
medicine, University of Oslo, Sognsvannsveien 21, N-0372, Oslo, Norway.
(4)Department of Psychiatry, Columbia University College of Physicians and
Surgeons, New York, NY, USA.
DOI: 10.1186/s12888-018-1778-8
PMCID: PMC6006963
PMID: 29914430 [Indexed for MEDLINE]
Kim M(1).
Author information:
(1)College of Nursing, Kangwon National University, Chuncheon-si, Gangwon-do,
Republic of Korea.
PMCID: PMC6500537
PMID: 31110975
Author information:
(1)Department of Drug Technology and Social Pharmacy, Lithuanian University of
Health Sciences, Sukileliu pr. 13, Kaunas, Lithuania. z.pranskuniene@gmail.com.
(2)Institute of Pharmaceutical Technologies, Lithuanian University of Health
Sciences, Kaunas, Lithuania. z.pranskuniene@gmail.com.
(3)Department of Drug Technology and Social Pharmacy, Lithuanian University of
Health Sciences, Sukileliu pr. 13, Kaunas, Lithuania.
(4)Department of Intensive Care, Lithuanian University of Health Sciences,
Kaunas, Lithuania.
(5)Institute of Pharmaceutical Technologies, Lithuanian University of Health
Sciences, Kaunas, Lithuania.
DOI: 10.1186/s13002-018-0268-x
PMCID: PMC6247776
PMID: 30458833 [Indexed for MEDLINE]
Author information:
(1)Departments of Cell Biology and Anatomy & Psychiatry, Hotchkiss Brain
Institute and Mathison Center for Mental Health Research and Education, Cumming
School of Medicine, University of Calgary, Calgary, AB, Canada.
(2)Department of Physiology and Pharmacology, Sapienza University of Rome, Rome,
Italy.
(3)Traumatic Stress Studies Division, Mount Sinai School of Medicine, James J
Peters VA Medical Center, Bronx, NY, USA.
(4)Department of Psychiatry and Behavioral Sciences, Nashville, TN, USA.
(5)Department of Pharmacology, Nashville, TN, USA.
(6)Department of Molecular Physiology & Biophysics, Nashville, TN, USA.
(7)The Vanderbilt Brain Institute, Vanderbilt University Medical Center,
Nashville, TN, USA.
DOI: 10.1038/npp.2017.162
PMCID: PMC5719095
PMID: 28745306 [Indexed for MEDLINE]
Amoah B(1)(2), Anto EA(1)(2), Osei PK(3)(2), Pieterson K(4), Crimi A(5)(6)(7).
Author information:
(1)ETH Zurich, Zurich, Switzerland.
(2)African Institute for Mathematical Sciences, P.O. Box DL 676, Cape Coast,
Ghana.
(3)University of Ghana, Accra, Ghana.
(4)Korle Bu Teaching Hospital, Accra, Ghana.
(5)ETH Zurich, Zurich, Switzerland. alessandro.crimi@iit.it.
(6)African Institute for Mathematical Sciences, P.O. Box DL 676, Cape Coast,
Ghana. alessandro.crimi@iit.it.
(7)Istituto Italiano di Tecnologia, Genoa, Italy. alessandro.crimi@iit.it.
BACKGROUND: The World Health Organization has recommended at least four antenatal
care (ANC) visits and skilled attendants at birth. Most pregnant women in rural
communities in low-income countries do not achieve the minimum recommended visits
and deliver without skilled attendants. With the aim of increasing number of ANC
visits, reducing home deliveries, and supplementing care given by ANC clinics, a
proposed system based on low-cost mobile phones and portable ultrasound scan
machines was piloted.
METHODS: A sample of 323 pregnant women from four rural communities in the
Central Region of Ghana were followed within a 11-month project. In each
community, at least one health worker was trained and equipped with a mobile
phone to promote ANC and hospital deliveries in her own community. If women
cannot attend ANC, technicians acquired scans by using portable ultrasound
machines in her community directly and sent them almost in real time to be
analyzed by a gynecologist in an urban hospital. A preliminary survey to assess
ANC status preceding the pilot study was conducted. During this, one hundred
women who had had pregnancies within five years prior to the study were
interviewed.
RESULTS: The preliminary survey showed that women who attended ANC were less
likely to have a miscarriage and more likely to have delivery at hospital or
clinic than those who did not, and women who attained at least four ANC visits
were less likely to practice self-medication. Among the women involved in the
project, 40 gave birth during the period of observation. The proposed prenatal
care approach showed that 62.5 % of pregnant women who gave birth during the
observation period included in the project (n=40) had their labor attended in
clinics or hospitals as against 37.5 % among the cases reported in the
pre-survey. One case of ectopic and two cases of breech pregnancies were detected
during the pilot through the proposed approach, and appropriate medical
interventions were sought.
CONCLUSION: Our results show that the proposed prenatal care approach can make
quality ANC accessible in rural communities where pregnant women have not been
able to access proper ANC.
DOI: 10.1186/s12884-016-0888-x
PMCID: PMC4906986
PMID: 27301244 [Indexed for MEDLINE]
Fernández Sánchez SP(1), Rusiñol Badals M(2), Padró Blanch I(3), Paytubí Garí
C(4), Laiz Alonso A(5), Moragues Pastor C(6); Grupo de Trabajo de Enfermería de
la SER.
Author information:
(1)Unidad de Reumatología, Hospital de la Santa Creu i Sant Pau, Barcelona,
España. Electronic address: sfernandez@santpau.cat.
(2)Servicio de Reumatología, Hospital Mutua de Terrassa, Barcelona, España.
(3)Servicio de Reumatología, Hospital del Mar, Barcelona, España.
(4)Departamento de Medicina Interna y Urgencias, Parc Sanitari Sant Joan de Déu,
Barcelona, España.
(5)Unidad de Reumatología, Hospital de la Santa Creu i Sant Pau, Barcelona,
España.
(6)Unidad de Reumatología, Hospital de la Santa Creu i Sant Pau, Barcelona,
España; Servicio de Reumatología, Hospital Platón, Barcelona, España.
DOI: 10.1016/j.reuma.2016.02.007
PMID: 27068066 [Indexed for MEDLINE]
657. Neural Plast. 2016;2016:6526437. doi: 10.1155/2016/6526437. Epub 2016 Feb 25.
Mismatch Negativity and P50 Sensory Gating in Abstinent Former Cannabis Users.
Broyd SJ(1), Greenwood LM(1), van Hell HH(1), Croft RJ(2), Coyle H(3), Lee-Bates
B(3), Todd J(4), Johnstone SJ(3), Michie PT(4), Solowij N(5).
Author information:
(1)School of Psychology, University of Wollongong, Wollongong, NSW 2522,
Australia; Illawarra Health and Medical Research Institute, University of
Wollongong, Wollongong, NSW 2522, Australia.
(2)School of Psychology, University of Wollongong, Wollongong, NSW 2522,
Australia; Illawarra Health and Medical Research Institute, University of
Wollongong, Wollongong, NSW 2522, Australia; Centre for Health Initiatives,
University of Wollongong, Wollongong, NSW 2522, Australia.
(3)School of Psychology, University of Wollongong, Wollongong, NSW 2522,
Australia.
(4)School of Psychology and Priority Research Centre for Translational
Neuroscience and Mental Health, University of Newcastle, Newcastle, NSW 2308,
Australia; Schizophrenia Research Institute, Sydney, NSW 2021, Australia.
(5)School of Psychology, University of Wollongong, Wollongong, NSW 2522,
Australia; Illawarra Health and Medical Research Institute, University of
Wollongong, Wollongong, NSW 2522, Australia; Schizophrenia Research Institute,
Sydney, NSW 2021, Australia.
DOI: 10.1155/2016/6526437
PMCID: PMC4785272
PMID: 27019754 [Indexed for MEDLINE]
Bennett B(1), Sharma M(2), Bennett R(3), Mawson AR(4), Buxbaum SG(4), Sung JH(4).
Author information:
(1)Epidemiologist, STD/HIV Office, Mississippi State Department of Health,
Jackson, Mississippi.
(2)Department of Behavioral & Environmental Health, School of Public Health,
Jackson State University, Jackson, Mississippi.
(3)Department of Health Policy & Management, Jackson State University, Jackson,
Mississippi.
(4)Department of Epidemiology & Biostatistics, Jackson State University, Jackson,
Mississippi.
DOI: 10.15171/jcs.2018.001
PMCID: PMC5889792
PMID: 29637050
659. Epilepsia Open. 2016 Sep 19;1(3-4):145-151. doi: 10.1002/epi4.12015.
eCollection
2016 Dec.
Morano A(1), Cifelli P(2)(3), Nencini P(2), Antonilli L(2), Fattouch J(1),
Ruffolo G(2), Roseti C(4), Aronica E(5)(6), Limatola C(2), Di Bonaventura C(1),
Palma E(2)(4), Giallonardo AT(1).
Author information:
(1)Department of Neurology and Psychiatry Pasteur Institute-Cenci Bolognetti
Foundation University of Rome Sapienza Rome Italy.
(2)Department of Physiology and Pharmacology Pasteur Institute-Cenci Bolognetti
Foundation University of Rome Sapienza Rome Italy.
(3)Ri.MED Foundation Palermo Italy.
(4)IRCCS San Raffaele Pisana Rome Italy.
(5)Department of (Neuro) Pathology Academic Medical Center University of
Amsterdam Amsterdam the Netherlands.
(6)Stichting Epilepsie Instellingen Nederland (SEIN-Heemstede) Amsterdam the
Netherlands.
DOI: 10.1002/epi4.12015
PMCID: PMC5719834
PMID: 29588939
660. Alcohol Clin Exp Res. 2017 Dec;41(12):2185-2196. doi: 10.1111/acer.13512. Epub
2017 Nov 10.
Colder CR(1), Shyhalla K(1), Frndak S(1), Read JP(1), Lengua LJ(2), Hawk LW
Jr(1), Wieczorek WF(3).
Author information:
(1)Department of Psychology, University at Buffalo, State University of New York,
Buffalo, New York.
(2)Department of Psychology, University of Washington, Seattle, Washington.
(3)Department of Epidemiology and Environmental Health, Buffalo State University,
Buffalo, New York.
DOI: 10.1111/acer.13512
PMCID: PMC5711530
PMID: 28945280 [Indexed for MEDLINE]
Author information:
(1)Department of Psychology and Neuroscience Program, Temple University,
Philadelphia, PA 19112, United States. Electronic address:
vinay.parikh@temple.edu.
(2)Department of Psychology and Neuroscience Program, Temple University,
Philadelphia, PA 19112, United States.
DOI: 10.1016/j.schres.2016.01.020
PMCID: PMC4762752 [Available on 2017-03-01]
PMID: 26803692 [Indexed for MEDLINE]
Kaye AD, Jones MR(1), Kaye AM, Ripoll JG(2), Galan V(3), Beakley BD(2), Calixto
F(2), Bolden JL(4), Urman RD, Manchikanti L.
Author information:
(1)Department of Anesthesiology, Louisiana State University Health New Orleans.
(2)Department of Anesthesiology, Tulane School of Medicine, New Orleans, LA.
(3)Georgia Pain Care, Atlanta, GA.
(4)Louisiana State University.
Chronic pain and prescription opioid abuse are extremely prevalent both in this
country and worldwide. Consequences of opioid misuse can be life-threatening with
significant morbidity and mortality, exacting a heavy toll on patients,
physicians, and society. Individuals with chronic pain and co-occurring substance
use disorders and/or mental health disorders, are at a higher risk for misuse of
prescribed opioids. Opioid abuse and misuse occurs for a variety of reasons,
including self-medication, use for reward, compulsive use because of addiction,
and diversion for profit. There is a significant need for treatment approaches
that balance treating chronic pain; while minimizing risks for opioid abuse,
misuse, and diversion. The use of chronic opioid therapy for chronic non-cancer
pain has increased dramatically in the past 2 decades in conjunction with
associated increases in the abuse of prescribed opioids and accidental opioid
overdoses. Consequently, a validated screening instrument which provides an
effective and rational method of selecting patients for opioid therapy,
predicting risk, and identifying problems once they arise could be of enormous
benefit in clinical practice. Such an instrument could potentially curb the risk
of iatrogenic addiction. Although several screening instruments and strategies
have been introduced in recent years, there is no single test or instrument which
can reliably and accurately predict those patients not suitable for opioid
therapy or identify those who need increased vigilance or monitoring during
therapy. At present, screening for opioid abuse includes assessment of premorbid
and comorbid substance abuse; assessment of aberrant drug-related behaviors; risk
factor stratification; and utilization of opioid assessment screening tools.
Multiple opioid assessment screening tools and instruments have been developed by
various authors. In addition, urine drug testing, monitoring of prescribing
practices, prescription monitoring programs, opioid treatment agreements, and
utilization of universal precautions are essential. Presently, a combination of
strategies is recommended to stratify risk, to identify and understand aberrant
drug related behaviors, and to tailor treatments accordingly. This manuscript
builds on the 2012 opioid guidelines published in Pain Physician and the 2016
guidelines released by the Centers for Disease Control and Prevention. It reviews
the current state of knowledge regarding the growing problem of opioid abuse and
misuse; known risk factors; and methods of predicting, assessing, monitoring, and
addressing opioid abuse and misuse in patients with chronic non-cancer pain.Key
words: Opioids, misuse, abuse, chronic pain, prevalence, risk assessment, risk
management, drug monitoring, aberrant drug-related behavior.
663. Eur Ann Otorhinolaryngol Head Neck Dis. 2015 Sep;132(4):181-4. doi:
10.1016/j.anorl.2015.06.004. Epub 2015 Jun 29.
Author information:
(1)Service d'oto-rhino-laryngologie et chirurgie cervico-faciale, faculté de
médecine et de pharmacie, hôpital des spécialités Rabat, 10000 Rabat, Morocco.
Electronic address: dr.a.bennani@gmail.com.
(2)Service d'oto-rhino-laryngologie et chirurgie cervico-faciale, faculté de
médecine et de pharmacie, hôpital des spécialités Rabat, 10000 Rabat, Morocco.
(3)Service d'oto-rhino-laryngologie et chirurgie cervico-faciale, faculté de
médecine et de pharmacie, hôpital des spécialités Rabat, 10000 Rabat, Morocco;
UFR d'ORL et de CMF, faculté de médecine et de pharmacie, université Mohmamed V,
Rabat, Morocco.
DOI: 10.1016/j.anorl.2015.06.004
PMID: 26139417 [Indexed for MEDLINE]
DOI: 10.1080/15504263.2015.1025013
PMCID: PMC4437848
PMID: 25793550 [Indexed for MEDLINE]
Poluzzi E(1), Raschi E(1), Godman B(2), Koci A(1), Moretti U(3), Kalaba M(4),
Wettermark B(5), Sturkenboom M(6), De Ponti F(1).
Author information:
(1)Department of Medical and Surgical Sciences, Alma Mater Studiorum-University
of Bologna, Bologna, Italy.
(2)Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden;
Strathclyde Institute of Pharmacy and Biomedical Sciences, Strathclyde
University, Glasgow, United Kingdom.
(3)Clinical Pharmacology Unit, University of Verona, Verona, Italy.
(4)Republic Fund for Health Insurance, Belgrade, Serbia.
(5)Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden;
Centre for Pharmacoepidemiology, Karolinska University Hospital, Solna,
Stockholm, Sweden; Stockholm, County Council, Stockholm, Sweden.
(6)Erasmus University Medical Centre, Rotterdam, Netherlands.
DOI: 10.1371/journal.pone.0119551
PMCID: PMC4364720
PMID: 25785934 [Indexed for MEDLINE]
Berg SA(1), Sentir AM, Bell RL, Engleman EA, Chambers RA.
Author information:
(1)Laboratory for Translational Neuroscience of Dual Diagnosis & Development,
Suite 314D, 320 West 16th Street, Indianapolis, IN, 46202, USA,
berg.fieler@gmail.com.
DOI: 10.1007/s00213-014-3800-2
PMCID: PMC4412763
PMID: 25388292 [Indexed for MEDLINE]
Association between nonmedical prescription drug use and health status among
young Swiss men.
N'Goran AA(1), Deline S(2), Henchoz Y(2), Baggio S(2), Studer J(2), Mohler-Kuo
M(3), Gmel G(4).
Author information:
(1)Alcohol Treatment Centre, Lausanne University Hospital CHUV, Lausanne,
Switzerland. Electronic address: Adjua-Alexandra.NGoran@chuv.ch.
(2)Alcohol Treatment Centre, Lausanne University Hospital CHUV, Lausanne,
Switzerland.
(3)Institute of Social and Preventive Medicine, University of Zurich, Zurich,
Switzerland.
(4)Alcohol Treatment Centre, Lausanne University Hospital CHUV, Lausanne,
Switzerland; Centre for Addiction and Mental Health, Toronto, Ontario, Canada;
University of the West of England, Frenchay Campus, Bristol, United Kingdom;
Addiction Switzerland, Lausanne, Switzerland.
PURPOSE: To examine the relationship between the nonmedical prescription drug use
(NMPDU) of six drug classes and health.
METHODS: Data on young adults males (mean age, 19.96 years) from the baseline and
follow-up of the Cohort Study on Substance Use Risk Factors (C-SURF) were used (n
= 4,958). Two sets of logistic regression models were fitted to examine the
associations between NMPDU of opioid analgesics, sedatives or sleeping pills,
anxiolytics, antidepressants, beta blockers and stimulants, and health status
(assessed using the Medical Outcomes Study 12-Item Short Form Survey Instrument
[SF-12 v2]). We first computed odds ratios between NMPDU at baseline and poor
mental and physical health at follow-up, adjusting for poor mental or physical
health at baseline. We then computed odds ratios between poor mental and physical
health at baseline and NMPDU at follow-up, adjusting for NMPDU at baseline.
RESULTS: Three key findings regarding mental health were (1) there was a
reciprocal risk between poor mental health and sedatives and anxiolytics; (2)
poor mental health increased NMPDU of opioid analgesics and antidepressants but
not vice versa; and (3) there were no associations with stimulants. Three key
findings regarding physical health were (1) poor physical health increased the
risk of NMPDU of anxiolytics; (2) the only reciprocal risk was between physical
health and NMPDU of opioid analgesics; and (3) there were no associations with
stimulants.
CONCLUSION: These results, among the first ever on reciprocal effects between
NMPDU and mental and physical health status, give unique information concerning
the adverse effects of NMPDU on health and vice versa. The study shows that NMPDU
is not only a sign of self-medication but may induce health problems.
DOI: 10.1016/j.jadohealth.2014.04.004
PMID: 24856409 [Indexed for MEDLINE]
A Smart Home System for Information Sharing, Health Assessments, and Medication
Self-Management for Older People: Protocol for a Mixed-Methods Study.
Author information:
(1)Department of Health and Care, School of Health and Welfare, Halmstad
University, Halmstad, Sweden.
(2)Technical Science, School of Information Technology, Halmstad University,
Halmstad, Sweden.
(3)Innovation Science, School of Business, Engineering and Science, Halmstad
University, Halmstad, Sweden.
(#)Contributed equally
BACKGROUND: Older adults often want to stay in a familiar place, such as their
home, as they get older. This so-called aging in place, which may involve support
from relatives or care professionals, can promote older people's independence and
well-being. The combination of aging and disease, however, can lead to complex
medication regimes and difficulties for care providers in correctly assessing the
older person's health. In addition, the organization of health care is
fragmented, which makes it difficult for health professionals to encourage older
people to participate in their own care. It is also a challenge to perform
adequate health assessments and to engage in appropriate communication between
health care professionals.
OBJECTIVE: The purpose of this paper is to describe the design for an integrated
home-based system that can acquire and compile health-related evidence for
guidance and information-sharing among care providers and care receivers in order
to support and promote medication self-management among older people.
METHODS: The authors used a participatory design approach for this mixed-methods
project, which was divided into four phases. Phase I, Conceptualization, consists
of the conceptualization of a system to support medication self-management,
objective health assessments, and communication between health care
professionals. Phase II, Development of a System, consists of building and
bringing together the conceptualized systems from Phase I. Phase III, Pilot
Study, and Phase IV, Full-Scale Intervention, are described briefly.
RESULTS: Participants in Phase I were people who were involved in some way in the
care of older adults and included older adults themselves, relatives of older
adults, care professionals, and industrial partners. With input from Phase I
participants, we identified two relevant concepts for promoting medication
self-management, both of which related to systems that participants believed
could provide guidance for the older adults themselves, relatives of older
adults, and care professionals. The systems will also encourage
information-sharing between care providers and care receivers. The first is the
concept of the Intelligent Age-Friendly Home (IAFH), defined as an integrated
residential system that evolves to sense, reason, and act in response to
individuals' needs, preferences, and behaviors as these change over time. The
second concept is the Medication safety, Objective assessments of health-related
behaviors, and Personalized medication reminders (MedOP) system, a system that
would be supported by the IAFH, and which consists of three related components:
one that assesses health behaviors, another that communicates health data, and a
third that promotes medication self-management.
CONCLUSIONS: The participants in this project were older adults, relatives of
older adults, care professionals, and our industrial partners. With input from
the participants, we identified two main concepts that could comprise a system
for health assessment, communication, and medication self-management: the IAFH
and the MedOP system. These concepts will be tested in this study to determine
whether they can facilitate and promote medication self-management among older
people.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/12447.
DOI: 10.2196/12447
PMCID: PMC6658282
PMID: 31038459
Author information:
(1)a University of Rochester School of Nursing , Rochester , NY , USA.
(2)b Johns Hopkins University, School of Medicine , Baltimore , MD , USA.
DOI: 10.1080/02770903.2016.1201835
PMCID: PMC5182183
PMID: 27337035 [Indexed for MEDLINE]
Author information:
(1)Wayne State University, kkolmodin@med.wayne.edu.
(2)Wayne State University.
(3)Nova Southeastern University, and.
© The Author 2015. Published by Oxford University Press on behalf of the Society
of Pediatric Psychology. All rights reserved. For permissions, please e-mail:
journals.permissions@oup.com.
DOI: 10.1093/jpepsy/jsv097
PMCID: PMC6080484
PMID: 26498724 [Indexed for MEDLINE]
Mohammad A(1).
Author information:
(1)VA Connecticut Healthcare System, Yale University School of Medicine, West
Haven, CT, 06516, USA, amir.mohammad@yale.edu.
Comment on
J Gen Intern Med. 2015 Mar;30(3):319-26.
DOI: 10.1007/s11606-014-3122-4
PMCID: PMC4351265
PMID: 25652538 [Indexed for MEDLINE]
Author information:
(1)Partners Healthcare, Connected Health, Boston, MA, United States.
tmhale@mgh.harvard.edu.
Erratum in
J Med Internet Res. 2019 Feb 05;21(2):e13125.
DOI: 10.2196/jmir.5256
PMCID: PMC4890732
PMID: 27154462 [Indexed for MEDLINE]
Cummings DM(1), Lutes LD(2), Littlewood K(3), Solar C(4), Hambidge B(1), Gatlin
P(1).
Author information:
(1)Departments of Family Medicine and Public Health and Center for Health
Disparities, East Carolina University, Greenville, NC.
(2)Department of Psychology, University of British Columbia, Canada.
(3)School of Social Work, University of South Florida, Tampa, FL.
(4)Department of Psychology, East Carolina University, Greenville, NC.
DOI: 10.18865/ed.27.2.155
PMCID: PMC5398174
PMID: 28439186 [Indexed for MEDLINE]
DOI: 10.12669/pjms.344.14994
PMCID: PMC6115554
PMID: 30190761
Sediq R(1), van der Schans J(1), Dotinga A(2), Alingh RA(2), Wilffert B(1)(3),
Bos JH(1), Schuiling-Veninga CC(1), Hak E(1)(4).
Author information:
(1)Department of Pharmaco-Therapy, Epidemiology & Economics, University of
Groningen, Groningen Research Institute of Pharmacy, Groningen, the Netherlands,
e.hak@rug.nl.
(2)Lifelines Cohort Study, Lifelines Databeheer B.V., Groningen, the Netherlands.
(3)Department of Clinical Pharmacy and Pharmacology, University Medical Center
Groningen, Groningen, the Netherlands.
(4)Department of Epidemiology, University Medical Center Groningen, Groningen,
the Netherlands, e.hak@rug.nl.
DOI: 10.2147/CLEP.S163037
PMCID: PMC6101003
PMID: 30147377
Schoenthaler AM(1), Butler M(2), Chaplin W(3), Tobin J(4)(5), Ogedegbe G(6).
Author information:
(1)Center for Healthful Behavior Change, Division of Health & Behavior,
Department of Population Health, New York University School of Medicine, 227 East
30th Street, 634, New York, NY, 10016, USA. antoinette.schoenthaler@nyumc.org.
(2)Center for Healthful Behavior Change, Division of Health & Behavior,
Department of Population Health, New York University School of Medicine, 227 East
30th Street, New York, NY, 10016, USA.
(3)Department of Psychology, St. John's University, Queens, NY, 11439, USA.
(4)Clinical Directors Network, Inc. (CDN), New York, NY, USA.
(5)The Rockefeller University, New York, NY, USA.
(6)Center for Healthful Behavior Change, Division of Health & Behavior,
Department of Population Health, New York University School of Medicine, 227 East
30th Street, 633, New York, NY, 10016, USA.
DOI: 10.1007/s12160-016-9791-y
PMCID: PMC5011034
PMID: 26944584 [Indexed for MEDLINE]
677. Health Psychol. 2015 May;34(5):505-13. doi: 10.1037/hea0000131. Epub 2014 Aug
11.
Author information:
(1)Ferkauf Graduate School of Psychology and Diabetes Research Center, Albert
Einstein College of Medicine, Yeshiva University.
(2)Ferkauf Graduate School of Psychology, Yeshiva University.
(3)Behavioral Medicine Service, Department of Psychiatry, Massachusetts General
Hospital.
DOI: 10.1037/hea0000131
PMCID: PMC4324372
PMID: 25110840 [Indexed for MEDLINE]
Author information:
(1)Pennsylvania State University, MC A480; 90 Hope Drive, Hershey, PA, 17033,
USA. lscalzi@pennstatehealth.psu.edu.
(2)Pennsylvania State University, MC A480; 90 Hope Drive, Hershey, PA, 17033,
USA.
Comment in
Nat Rev Rheumatol. 2018 Aug;14(8):445-446.
DOI: 10.1186/s12969-018-0232-2
PMCID: PMC5852975
PMID: 29540181 [Indexed for MEDLINE]
679. Pharmacy (Basel). 2018 May 28;6(2). pii: E46. doi: 10.3390/pharmacy6020046.
Houlind MB(1)(2), McNulty HBØ(3), Treldal C(4)(5), Andersen SL(6), Huneck Haupt
T(7), Petersen J(8)(9), Andersen O(10)(11), Kjeldsen LJ(12).
Author information:
(1)Optimed, Clinical Research Centre, Copenhagen University Hospital Hvidovre,
Kettegård Alle 30, Department 056, 2650 Hvidovre, Denmark.
morten.batlzer.houlind@regionh.dk.
(2)The Capital Region Pharmacy, Marielundvej 25, 2730 Herlev, Denmark.
morten.batlzer.houlind@regionh.dk.
(3)The Capital Region Pharmacy, Marielundvej 25, 2730 Herlev, Denmark.
helle.bach.oelgaard.mcnulty@regionh.dk.
(4)Optimed, Clinical Research Centre, Copenhagen University Hospital Hvidovre,
Kettegård Alle 30, Department 056, 2650 Hvidovre, Denmark.
charlotte.treldal.02@regionh.dk.
(5)The Capital Region Pharmacy, Marielundvej 25, 2730 Herlev, Denmark.
charlotte.treldal.02@regionh.dk.
(6)Optimed, Clinical Research Centre, Copenhagen University Hospital Hvidovre,
Kettegård Alle 30, Department 056, 2650 Hvidovre, Denmark.
signe.lindegaard.andersen@regionh.dk.
(7)Optimed, Clinical Research Centre, Copenhagen University Hospital Hvidovre,
Kettegård Alle 30, Department 056, 2650 Hvidovre, Denmark.
thomas.huneck.haupt.01@regionh.dk.
(8)Optimed, Clinical Research Centre, Copenhagen University Hospital Hvidovre,
Kettegård Alle 30, Department 056, 2650 Hvidovre, Denmark.
janne.petersen.01@regionh.dk.
(9)Section of Biostatistics, Department of Public Health, University of
Copenhagen, 1014 Copenhagen, Denmark. janne.petersen.01@regionh.dk.
(10)Optimed, Clinical Research Centre, Copenhagen University Hospital Hvidovre,
Kettegård Alle 30, Department 056, 2650 Hvidovre, Denmark.
ove.andersen@regionh.dk.
(11)Emergency Department, Copenhagen University Hospital, 2650 Hvidovre, Denmark.
ove.andersen@regionh.dk.
(12)Amgros I/S, Dampfærgevej 27, 2100 Copenhagen, Denmark.
ljuelkjeldsen@gmail.com.
(1) Objective: To assess hospital medication costs and staff time between
One-Stop Dispensing (OSD) and the Traditional Medication System (TMS), and to
evaluate patient perspectives on OSD. (2) Methods: The study was conducted at
Hvidovre Hospital, University of Copenhagen, Denmark in an elective gastric
surgery and acute orthopedic surgery department. This study consists of three
sub-studies including adult patients able to self-manage medication. In Sub-study
1, staff time used to dispense and administer medication in TMS was assessed.
Medication cost and OSD staff time were collected in Sub-study 2, while patient
perspectives were assessed in Sub-study 3. Medication costs with two days of
discharge medication were compared between measured OSD cost and simulated TMS
cost for the same patients. Measured staff time in OSD was compared to simulated
staff time in TMS for the same patients. Patient satisfaction related to OSD was
evaluated by a questionnaire based on a five-point Likert scale ('very poor' (1)
to 'very good' (5)). (3) Results: In total, 78 elective and 70 acute OSD patients
were included. Overall, there was no significant difference between OSD and TMS
in medication cost per patient ($2.03 [95% CI -0.57⁻4.63]) (p = 0.131). Compared
with TMS, OSD significantly reduced staff time by an average of 12 min (p ≤
0.001) per patient per hospitalization. The patients' satisfaction for OSD was
high with an average score of 4.5 ± 0.7. (4) Conclusion: There were no
differences in medication costs, but staff time was significantly lower in OSD
and patients were overall satisfied with OSD.
DOI: 10.3390/pharmacy6020046
PMCID: PMC6025360
PMID: 29843357
Author information:
(1)Human Technology Interaction, Eindhoven University of Technology, Eindhoven,
the Netherlands ; Behavior, Cognition and Perception, Philips Research,
Eindhoven, the Netherlands.
(2)Behavior, Cognition and Perception, Philips Research, Eindhoven, the
Netherlands.
(3)Human Technology Interaction, Eindhoven University of Technology, Eindhoven,
the Netherlands.
Links between blood pressure and medication intake, well-being, stress, physical
activity and symptoms reported via a mobile phone-based self-management support
system: a cohort study in primary care.
Author information:
(1)Institute of Health and Care Sciences, Sahlgrenska Academy, University of
Gothenburg, Gothenburg, Sweden.
(2)Centre for Person-Centred Care (GPCC), Sahlgrenska Academy, University of
Gothenburg, Gothenburg, Sweden.
(3)Department of Medical and Health Sciences, Linköping University, Linköping,
Sweden.
(4)Department of Molecular and Clinical Medicine, Institute of Medicine,
Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
(5)Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg,
Sweden.
DOI: 10.1136/bmjopen-2017-020849
PMCID: PMC6112389
PMID: 30139897
Vankova B(1), Mala-Ladova K(1), Kubena AA(1), Maly J(1), Sulkova SD(2).
Author information:
(1)Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec
Králové, Charles University, Hradec Králové, Czech Republic, malyj@faf.cuni.cz.
(2)Hemodialysis Centre, University Hospital, Hradec Králové, Czech Republic.
DOI: 10.2147/PPA.S184166
PMCID: PMC6287542
PMID: 30584284
Criteria for the selection of switch OTC drugs based on patient benefits,
efficacy, and safety [II]: Comparing the physicochemical and pharmaceutical
properties of brand-name and switch OTC terbinafine hydrochloride cream.
Takata M(1), Wada Y(2), Iwasawa Y(3), Kumazawa M(4), Shimokawa KI(3), Ishii F(2).
Author information:
(1)Welcia Yakkyoku Co. Ltd.
(2)Department of Self-medication and Health Care Sciences, Meiji Pharmaceutical
University.
(3)Department of Pharmaceutical Sciences, Meiji Pharmaceutical University.
(4)Department of Mathematical Science, Meiji Pharmaceutical University.
The physicochemical properties (pH, yield value, and squeeze force) of a drug for
dermatomycosis, a terbinafine hydrochloride-containing cream (a brand-name
product), and 12 over-the-counter drugs (OTCs) were measured and compared to
ascertain the characteristics of each product. The pH of the brand-name product,
Lamisil, was 4.1, and that of the OTC products ranged from 4.2 to 7.6; Lamisil
Plus (7.6) had a significantly higher pH. Moreover, the yield value for Lamisil,
as an index of cream ductility, was 128 dyn/cm2, and that for the OTC products
ranged from 110 to 887 dyn/cm2. In particular, the OTC products Damalin (887
dyn/cm2), Barriact (512 dyn/cm2), and Exiv Deep (663 dyn/cm2) had a significantly
higher yield value. In addition, the squeeze force was measured by attaching a
HapLog® to the thumb and second finger. The squeeze force for Lamisil was 12.9 N,
and that for the OTC products ranged from 1.8 to 14.6 N. The OTC product Bilumon
(1.8 N) had a significantly lower squeeze force. These results indicated that
there were marked differences in the pharmaceutical properties of brand-name and
OTC products. External preparations are characterized by their feel during use.
Based on the current results, the pharmaceutical characteristics of drugs
resulted in differences in their feel during use, suggesting that products
appropriate for individual patients can be recommended.
DOI: 10.5582/ddt.2018.01043
PMID: 30224597 [Indexed for MEDLINE]
Author information:
(1)Rehabilitation and Recovery, Adult Psychiatry, Northumberland, Tyne and Wear
NHS Foundation Trust, Newcastle, UK.
BACKGROUND: People with a serious mental illness are more likely to smoke more
and to be more dependent smokers than the general population. This may be due to
a wide range of factors that could include a common aetiology to both smoking and
the illness, self medication, smoking to alleviate adverse effects of
medications, boredom in the existing environment, or a combination of these
factors. It is important to undertake this review to facilitate improvements in
both the health and safety of people with serious mental illness who smoke, and
to reduce the overall burden of costs (both financial and health) to the smoker
and, eventually, to the taxpayer.
OBJECTIVES: To review the effects of smoking cessation advice for people with
serious mental illness.
SEARCH METHODS: We searched the Cochrane Schizophrenia Group Specialized Trials
Register up to 2 April 2015, which is based on regular searches of CENTRAL,
BIOSIS, PubMed, MEDLINE, EMBASE, CINAHL, PsycINFO, and trial registries. We also
undertook unsystematic searches of a sample of the component databases (BNI,
CINHAL, EMBASE, MEDLINE, and PsycINFO), up to 2 April 2015, and searched
references of all identified studies
SELECTION CRITERIA: We planned to include all randomised controlled trials (RCTs)
that focussed on smoking cessation advice versus standard care or comparing
smoking cessation advice with other more focussed methods of delivering care or
information.
DATA COLLECTION AND ANALYSIS: The review authors (PK, AC, and DB) independently
screened search results but did not identify any trials that fulfilled the
inclusion criteria of this review.
MAIN RESULTS: We did not identify any RCTs that evaluated advice regarding
smoking cessation for people with serious mental illness. The excluded studies
illustrate that randomisation of packages of care relevant to smokers with
serious mental illness is possible.
AUTHORS' CONCLUSIONS: People with serious mental illness are more likely to smoke
than the general population. Yet we could not find any high quality evidence to
guide the smoking cessation advice healthcare professionals pass onto service
users. This is an area where trials are possible and needed.
DOI: 10.1002/14651858.CD009704.pub2
PMCID: PMC6513396
PMID: 26816385 [Indexed for MEDLINE]
Author information:
(1)Department of Clinical Sciences in Malmö/Family Medicine, Lund University, Jan
Waldenströms gata 35, SE-205 02, Malmö, Sweden. sara.modig@med.lu.se.
(2)Department of Medicines Management and Informatics in Skåne County, Malmö,
Sweden. sara.modig@med.lu.se.
(3)Department of Clinical Sciences in Malmö/Family Medicine, Lund University, Jan
Waldenströms gata 35, SE-205 02, Malmö, Sweden.
(4)Department for Public Health Sciences, Karolinska Institutet, Stockholm,
Sweden.
DOI: 10.1186/s12875-016-0542-8
PMCID: PMC5050592
PMID: 27716124 [Indexed for MEDLINE]
Umberson D(1), Thomeer MB(2), Williams K(3), Thomas PA(4), Liu H(5).
Author information:
(1)Department of Sociology and Population Research Center, The University of
Texas at Austin. umberson@prc.utexas.edu.
(2)Department of Sociology, University of Alabama at Birmingham.
(3)Department of Sociology, Ohio State University, Columbus.
(4)Department of Sociology and Center on Aging and the Life Course, Purdue
University, West Lafayette, Indiana.
(5)Department of Sociology, Michigan State University, East Lansing.
OBJECTIVES: Prior U.S. population studies have found that childhood adversity
influences the quality of relationships in adulthood, with emerging research
suggesting that this association might be especially strong for black men. We
theorize psychosocial and behavioral coping responses to early life adversity and
how these responses may link early life adversity to strain in men's
relationships with their indeterminate partners and children across the life
course, with attention to possible racial variation in these experiences and
implications for later life well-being.
METHOD: We analyze in-depth interviews with 15 black men and 15 white men. We use
qualitative analysis techniques to connect childhood experiences to psychosocial
processes in childhood and behavioral coping strategies associated with
relationship experiences throughout adulthood.
RESULTS: Black men describe much stronger and more persistent childhood adversity
than do white men. Findings further suggest that childhood adversity contributes
to psychosocial processes (e.g., diminished sense of mastery) that may lead to
ways of coping with adversity (e.g., self-medication) that are likely to
contribute to relationship difficulties throughout the life span.
DISCUSSION: A life course perspective directs attention to the early life origins
of cumulative patterns of social disadvantage, patterns that extend to later
life. Our findings suggest psychosocial and behavioral pathways through which
early life adversity may constrain and strain men's relationships, possibly
contributing to racial inequality in family relationships across the life span.
DOI: 10.1093/geronb/gbv091
PMCID: PMC4982387
PMID: 26589348 [Indexed for MEDLINE]
687. Public Health Res Pract. 2017 Oct 11;27(4). pii: 27341702. doi:
10.17061/phrp27341702.
Author information:
(1)Faculty of Pharmacy, University of Sydney, NSW, Australia,
danijela.gnjidic@sydney.edu.au.
(2)National Centre for Epidemiology and Population Health, Research School of
Population Health, Australian National University, Canberra, ACT.
(3)Faculty of Pharmacy, University of Sydney, NSW, Australia; Centre for Big Data
Research in Health, Faculty of Medicine, UNSW Sydney, Australia.
(4)Sydney Medical School, University of Sydney, NSW, Australia; Kolling
Institute, Sydney, NSW, Australia; Royal North Shore Hospital, Sydney, NSW,
Australia.
(5)National Centre for Epidemiology and Population Health, Research School of
Population Health, Australian National University, Canberra, ACT; Sax Institute,
Sydney, NSW, Australia.
DOI: 10.17061/phrp27341702
PMID: 29114718 [Indexed for MEDLINE]
Schumacher KL(1), Plano Clark VL(2), West CM(3), Dodd MJ(3), Rabow MW(3),
Miaskowski C(3).
Author information:
(1)College of Nursing, University of Nebraska Medical Center, Omaha, Nebraska,
USA. Electronic address: kschumacher@unmc.edu.
(2)University of Cincinnati, Cincinnati, Ohio, USA.
(3)University of California San Francisco, San Francisco, California, USA.
Comment in
J Pain Symptom Manage. 2014 Nov;48(5):760-1.
DOI: 10.1016/j.jpainsymman.2013.12.247
PMCID: PMC4185301
PMID: 24709364 [Indexed for MEDLINE]
Author information:
(1)University of Mauritius, Faculty of Social Studies and Humanities, Department
of Economics and Statistics, Réduit, Mauritius.
(2)Universiti Teknologi MARA, Faculty of Computer and Mathematical Sciences,
Centre of Statistical and Decision Science Studies, Sek 1, Shah Alam, Malaysia.
(3)Universiti Sains Malaysia, School of Pharmaceutical Sciences, Penang,
Malaysia.
DOI: 10.1016/j.jcte.2017.07.003
PMCID: PMC5651286
PMID: 29067270
690. Aust Fam Physician. 2016 Sep;45(9):661-7.
BACKGROUND: Limited studies have explored the actual usage of the 'after hours GP
helpline' (AGPH).
OBJECTIVE: The objectives of the article are to describe medication-related calls
to the AGPH and compare callers' original intentions versus the advice provided
by the general practitioner (GP).
METHODS: We performed a detailed descriptive statistical analysis of
medication-related queries received by the AGPH in 2014.
RESULTS: In 2014, 13,600 medication-related calls were made to the national AGPH.
For 86.56% of calls, GPs advised callers to either self-care only, or self-care
overnight and see their GP during business hours. Of the 1442 calls where the
caller had originally intended to visit the emergency department (ED), 76.70%
were advised by GPs to self-care, and only 5.48% were advised to call 000 or
visit an ED. Overall, less than 2.26% of callers were directed to the ED, despite
10.60% of people originally calling with this intention.
DISCUSSION: The availability of an after-hours service potentially prevented 1363
people from unnecessarily attending an ED and directed 228 people who had
originally underestimated the seriousness of their condition to an ED.
Cannabis Use, Medication Management and Adherence Among Persons Living with HIV.
Author information:
(1)School of Nursing and Health Sciences, University of Miami, 5030 Brunson Ave,
Coral Gables, FL, 33146, USA. DVidot@miami.edu.
(2)Department of Psychology, Center for Children and Families, Florida
International University, Miami, FL, USA.
Cannabis is used to relieve nausea, trigger weight gain, and reduce pain among
adults living with HIV; however, the relationship between its use and medication
adherence and management is unclear. Participants (N = 107) were from an ongoing
cohort study of community-dwelling HIV+ adults, stratified by cannabis (CB) use:
HIV+/CB+ (n = 41) and HIV+/CB- (n = 66). CB+ participants either tested positive
in a urine toxicology screen for THC or had a self-reported history of regular
and recent use. HIV-status was provided by physician results and/or biomarker
assessment. Adherence was measured via the Morisky scale and medication
management was assessed via the Medication Management Test-Revised. After
adjusting for gender, we found no association between cannabis use group and
adherence nor medication management. The amount of cannabis used was also not
associated with measures of adherence and management. Preliminary findings
suggest that cannabis use may not adversely influence medication
adherence/management among adults living with HIV.
DOI: 10.1007/s10461-017-1782-x
PMCID: PMC5503453
PMID: 28456895 [Indexed for MEDLINE]
Author information:
(1)Pudong Yingbo Community Health Service Center, Shanghai, China.
Publisher:
许多社区精神分裂症患者服药不规律因而很容易频繁复发。评估自我管理培训对社区慢性精神分裂症患者服药依
从性和复发情况的影响。共纳入上海市城市和农村的社区慢性精神分裂症
患者 201 例,随机分为常规治疗组(n=98)或自我管理干预组(n=103)。干预组接受为期 6 个月的每周一次自
我管理技能培训,之后参加每月一次的加强小组会议,由社区
卫生工作者检查患者的自我管理清单,共 24 个月。由两名单盲于患者治疗情况的精神科医生使用 Morisky 服药
依从性量表评估患者服药依从性并采用自知力评估量表(Scal
e to Assess Unawareness of Mental
Disorders,SAUMD)了解基线时和 30 个月后患者的自知力。总共 194 人(95.6%)完成研究。基线时两组间
无显著差异,但在 30 个月后,干预组服药依从性比
常规治疗组好,对疾病的自知力提高,自我报告使用抗精神病药物的剂量相对高。在随访 30 个月里,干预组 103
例患者中只有 2 例(1.9%)复发(即一次或多次住院),然而对
照组 98 例患者中有 14 例(14.3%)复发(X2=8.83,
p=0.003)。本研究样本量大、随访时间相对长、随机设计并采用单盲法评估,研究结果的说服力相对强。本研
究发现自我管理干预后患者复发显著减少、服药依从性改善以及自
知力提高。这些结果拓展了我们先前的研究发现,显示自我管理训练可以有效改善社区慢性精神分裂症患者的症
状和社会功能。今后需要纳入成本效益分析研究,评估将自我管理干预扩
大到其他更多社区的可行性。
DOI: 10.11919/j.issn.1002-0829.214076
PMCID: PMC4311106
PMID: 25642107
693. J Gerontol A Biol Sci Med Sci. 2018 Jun 19. doi: 10.1093/gerona/gly104. [Epub
ahead of print]
Is Who you Ask Important? Concordance Between Survey and Registry Data on
Medication Use Among Self- and Proxy-Respondents in the Longitudinal Study of
Aging Danish Twins and the Danish 1905-Cohort Study.
Oksuzyan A(1), Sauer T(1)(2), Gampe J(1), Höhn A(1)(3), Wod M(3)(4), Christensen
K(3)(4), Wastesson JW(5).
Author information:
(1)Max Planck Institute for Demographic Research, Rostock, Germany.
(2)Institute for Sociology and Demography, University of Rostock, Germany.
(3)Department of Epidemiology, Biostatistics and Biodemography, Institute of
Public Health, University of Southern Denmark, Odense.
(4)Danish Aging Research Center, Institute of Public Health, University of
Southern Denmark, Odense.
(5)Aging Research Center, Department of Neurobiology, Care Sciences and Society,
Karolinska Institute and Stockholm University, Sweden.
DOI: 10.1093/gerona/gly104
PMCID: PMC6477639
PMID: 29924318
694. Pharmacoepidemiol Drug Saf. 2016 Jul;25(7):827-35. doi: 10.1002/pds.3970. Epub
2016 Jan 29.
Colantonio LD(1), Kent ST(1), Kilgore ML(2), Delzell E(1), Curtis JR(1)(3),
Howard G(4), Safford MM(3), Muntner P(1)(3).
Author information:
(1)Department of Epidemiology, University of Alabama at Birmingham, Birmingham,
AL, USA.
(2)Department of Health Care Organization and Policy, University of Alabama at
Birmingham, Birmingham, AL, USA.
(3)Department of Medicine, University of Alabama at Birmingham, Birmingham, AL,
USA.
(4)Department of Biostatistics, University of Alabama at Birmingham, Birmingham,
AL, USA.
Comment in
Pharmacoepidemiol Drug Saf. 2016 Jul;25(7):844-6.
DOI: 10.1002/pds.3970
PMCID: PMC5039944
PMID: 26823152 [Indexed for MEDLINE]
Zheng Y(1), Jit M(2)(3), Wu JT(4), Yang J(1), Leung K(4), Liao Q(1), Yu H(5).
Author information:
(1)Key Laboratory of Surveillance and Early-warning on Infectious Disease,
Division of Infectious Disease, Chinese Center for Disease Control and
Prevention, Beijing, China.
(2)Modelling and Economics Unit, Public Health England, London, United Kingdom.
(3)Department of Infectious Disease Epidemiology, London School of Hygiene &
Tropical Medicine, London, United Kingdom.
(4)WHO Collaborating Centre for Infectious Disease Epidemiology and Control,
School of Public Health, Li Ka Shing Faculty of Medicine, the University of Hong
Kong, Hong Kong Special Administrative Region, China.
(5)School of Public Health, Fudan University, Key Laboratory of Public Health
Safety, Ministry of Education, Shanghai, China.
BACKGROUND: Hand, foot and mouth disease (HFMD) is a common illness in China that
mainly affects infants and children. The objective of this study is to assess the
economic cost and health-related quality of life associated with HFMD in China.
METHOD: A telephone survey of caregivers were conducted in 31 provinces across
China. Caregivers of laboratory-confirmed HFMD patients who were registered in
the national HFMD enhanced surveillance database during 2012-2013 were invited to
participate in the survey. Total costs included direct medical costs (outpatient
care, inpatient care and self-medication), direct non-medical costs
(transportation, nutrition, accommodation and nursery), and indirect costs for
lost income associated with caregiving. Health utility weights elicited using
EuroQol EQ-5D-3L and EQ-Visual Analogue Scale (VAS) were used to calculate
associated loss in quality adjusted life years (QALYs).
RESULTS: The subjects comprised 1136 mild outpatients, 1124 mild inpatients, 1170
severe cases and 61 fatal cases. The mean total costs for mild outpatients, mild
inpatients, severe cases and fatal cases were $201 (95%CI $187, $215), $1072
(95%CI $999, $1144), $3051 (95%CI $2905, $3197) and $2819 (95%CI $2068, $3571)
respectively. The mean QALY losses per HFMD episode for mild outpatients, mild
inpatients and severe cases were 3.6 (95%CI 3.4, 3,9), 6.9 (95%CI 6.4, 7.4) and
13.7 (95%CI 12.9, 14.5) per 1000 persons. Cases who were diagnosed with EV-A71
infection and had longer duration of illness were associated with higher total
cost and QALY loss.
CONCLUSION: HFMD poses a high economic and health burden in China. Our results
provide economic and health utility data for cost-effectiveness analysis for HFMD
vaccination in China.
DOI: 10.1371/journal.pone.0184266
PMCID: PMC5608208
PMID: 28934232 [Indexed for MEDLINE]
Mpimbaza A(1), Katahoire A(2), Rosenthal PJ(3), Karamagi C(4)(5), Ndeezi G(4).
Author information:
(1)Child Health and Development Centre, Makerere University, College of Health
Sciences, Kampala, Uganda. arthurwakg@yahoo.com.
(2)Child Health and Development Centre, Makerere University, College of Health
Sciences, Kampala, Uganda.
(3)Department of Medicine, University of California, San Francisco, USA.
(4)Department of Pediatrics and Child Health, Makerere University, College of
Health Sciences, Kampala, Uganda.
(5)Clinical Epidemiology Unit, Department of Medicine, Makerere University,
College of Health Sciences, Kampala, Uganda.
DOI: 10.1186/s12936-018-2630-9
PMCID: PMC6299589
PMID: 30563514 [Indexed for MEDLINE]
Geryk LL(1), Blalock SJ(1), DeVellis RF(2), Jordan JM(3), Han PK(4), Carpenter
DM(1).
Author information:
(1)University of North Carolina, UNC Eshelman School of Pharmacy, Division of
Pharmaceutical Outcomes and Policy, Chapel Hill, NC, USA.
(2)University of North Carolina, Gillings School of Global Public Health,
Department of Health Behavior, University of North Carolina, Chapel Hill, USA.
(3)Thurston Arthritis Research Center, University of North Carolina, Chapel Hill,
USA.
(4)Maine Medical Center, Center for Outcomes Research and Evaluation, Portland,
ME, USA.
OBJECTIVE: The aim of this study was to investigate the relationship between the
attentional coping styles (monitoring and blunting) of rheumatoid arthritis (RA)
and osteoarthritis (OA) patients and: (a) receipt of medication information; (b)
receipt of conflicting medication information; (c) ambiguity aversion; (d)
medication-related discussions with doctors and spouse/partners; and (e)
medication adherence.
METHOD: A sample of 328 adults with a self-reported diagnosis of arthritis (RA
n=159; OA n=149) completed an Internet-based survey. Coping style was assessed
using the validated short version of the Miller Behavioral Style Scale. Measures
related to aspects of medication information receipt and discussion and validated
measures of ambiguity aversion and medication adherence (Vasculitis
Self-Management Survey) were collected. Pearson correlation coefficients, ANOVA,
independent samples t-tests and multiple regression models were used to assess
associations between coping style and the other variables of interest.
RESULTS: Arthritis patients in our sample were more likely to be high monitors
(50%) than high blunters (36%). Among RA patients, increased information-receipt
was significantly associated with decreased monitoring (b = -1.06, p = .001).
Among OA patients, increased information-receipt was significantly associated
with increased blunting (b = .60, p = .02).
CONCLUSION: In our sample of patients with arthritis, attentional coping style is
not in accordance with the characteristic patterns outlined in the acute and
chronic disease coping literature.
DOI: 10.2174/1874312901610010060
PMCID: PMC5080870
PMID: 27843510
Author information:
(1)Digital medicine, Scripps Translational Science Institute, La Jolla, CA,
United States.
DOI: 10.2196/jmir.5429
PMCID: PMC4935792
PMID: 27334418 [Indexed for MEDLINE]
Carpenter DM(1), Blalock SJ, Sayner R, Muir KW, Robin AL, Hartnett ME,
Giangiacomo AL, Tudor GE, Sleath BL.
Author information:
(1)*PhD, MSPH †PhD, MPH ‡PharmD §MD ∥PhD Division of Pharmaceutical Outcomes and
Policy (DMC), University of North Carolina at Chapel Hill, Asheville Satellite
Campus, Asheville, North Carolina; Division of Pharmaceutical Outcomes and Policy
(SJB, BLS), University of North Carolina at Chapel Hill, Chapel Hill, North
Carolina; School of Medicine (RS), Stanford University, Stanford, California;
Duke University School of Medicine & Durham VA Medical Center (KWM), Durham,
North Carolina; Wilmer Institute and Bloomberg School of Public Health (ALR),
Johns Hopkins University, Baltimore, Maryland; Department of Ophthalmology (ALR),
University of Maryland, College Park, Maryland; John A. Moran Eye Center (MEH),
University of Utah, Salt Lake City, Utah; School of Medicine (ALG), Emory
University, Atlanta, Georgia; and Department of Mathematics and Statistics (GET),
Husson University, Bangor, Maine.
DOI: 10.1097/OPX.0000000000000856
PMCID: PMC4915983
PMID: 27003815 [Indexed for MEDLINE]
Author information:
(1)James M. Anderson Center, Cincinnati Children's Hospital, Cincinnati, Ohio,
USA.
DOI: 10.1159/000447700
PMCID: PMC5063697
PMID: 27487185 [Indexed for MEDLINE]
Kenning C(1), Coventry PA(2), Gibbons C(3), Bee P(4), Fisher L(3), Bower P(5).
Author information:
(1)Institute of Population Health, NIHR School for Primary Care Research, Centre
for Primary Care, Manchester Academic Health Science Centre (MAHSC),
Cassandra.kenning@manchester.ac.uk.
(2)Institute of Population Health, NIHR Collaboration for Applied Health Research
and Care, Greater Manchester (GM-CLAHRC), Manchester Academic Health Science
Centre (MAHSC).
(3)Institute of Population Health, NIHR School for Primary Care Research, Centre
for Primary Care, Manchester Academic Health Science Centre (MAHSC).
(4)Institute of Population Health, School of Nursing, Midwifery and Social Work
and.
(5)Institute of Population Health, NIHR Greater Manchester Primary Care Patient
Safety Translational Research Centre, Centre for Primary Care, Manchester
Academic Health Science Centre (MAHSC), University of Manchester, Manchester, UK.
DOI: 10.1093/fampra/cmv002
PMCID: PMC4445135
PMID: 25715962 [Indexed for MEDLINE]
Still I rise: The need for self-validation and self-care in the midst of
adversities faced by Black women with HIV.
Dale SK(1), Pierre-Louis C(1), Bogart LM(2), O'Cleirigh C(1), Safren SA(3).
Author information:
(1)Department of Psychiatry, Massachusetts General Hospital.
(2)RAND Health, RAND Corporation.
(3)Psychology Department, University of Miami.
DOI: 10.1037/cdp0000165
PMCID: PMC5726949
PMID: 28604021 [Indexed for MEDLINE]
Author information:
(1)Department of Veterans Affairs, Providence VA Medical Center, Providence, RI,
USA.
(2)Department of Pharmacy Practice, University of Rhode Island, Kingston, RI,
USA.
(3)Department of Medicine, Alpert Medical School, Brown University, Providence,
RI, USA.
(4)Phoenix VA Healthcare System, Phoenix, AZ, USA.
DOI: 10.1177/2374373517714452
PMCID: PMC5734515
PMID: 29276763
704. AMIA Annu Symp Proc. 2017 Feb 10;2016:984-993. eCollection 2016.
Author information:
(1)department of Biomedical Informatics, Columbia University, New York.
PMCID: PMC5333323
PMID: 28269895 [Indexed for MEDLINE]
705. Kidney Int. 2017 Oct;92(4):972-978. doi: 10.1016/j.kint.2017.03.018. Epub 2017
May 18.
Wild MG(1), Wallston KA(1), Green JA(2), Beach LB(3), Umeukeje E(3), Wright Nunes
JA(4), Ikizler TA(3), Steed J(5), Cavanaugh KL(6).
Author information:
(1)Vanderbilt University, Nashville, Tennessee, USA; Vanderbilt University
Medical Center, Nashville, Tennessee, USA; Vanderbilt Center for Kidney Disease,
Nashville, Tennessee, USA.
(2)Geisinger Health System, Danville, Pennsylvania, USA.
(3)Vanderbilt University Medical Center, Nashville, Tennessee, USA; Vanderbilt
Center for Kidney Disease, Nashville, Tennessee, USA.
(4)University of Michigan, Ann Arbor, Michigan, USA.
(5)Vanderbilt University, Nashville, Tennessee, USA.
(6)Vanderbilt University Medical Center, Nashville, Tennessee, USA; Vanderbilt
Center for Kidney Disease, Nashville, Tennessee, USA. Electronic address:
kerri.cavanaugh@vanderbilt.edu.
Chronic Kidney Disease (CKD) is a major burden on patients and the health care
system. Treatment of CKD requires dedicated involvement from both caretakers and
patients. Self-efficacy, also known as perceived competence, contributes to
successful maintenance of patient's CKD self-management behaviors such as
medication adherence and dietary regulations. Despite a clear association between
self-efficacy and improved CKD outcomes, there remains a lack of validated
self-report measures of CKD self-efficacy. To address this gap, the Perceived
Kidney/Dialysis Self-Management Scale (PKDSMS) was adapted from the previously
validated Perceived Medical Condition Self-Management Scale. We then sought to
validate this using data from two separate cohorts: a cross-sectional
investigation of 146 patients with end-stage renal disease receiving maintenance
hemodialysis and a longitudinal study of 237 patients with CKD not receiving
dialysis. The PKDSMS was found to be positively and significantly correlated with
self-management behaviors and medication adherence in both patient cohorts. The
PKDSMS had acceptable reliability, was internally consistent, and exhibited
predictive validity between baseline PKDSMS scores and self-management behaviors
across multiple time points. Thus, the PKDSMS is a valid and reliable measure of
CKD patient self-efficacy and supports the development of interventions enhancing
perceived competence to improve CKD self-management.
DOI: 10.1016/j.kint.2017.03.018
PMCID: PMC5610608
PMID: 28528132 [Indexed for MEDLINE]
Author information:
(1)UCL Medical School, London, UK.
(2)School of Clinical Medicine, University of Cambridge, Cambridge, UK.
(3)Department of Public Health and Primary Care, University of Cambridge,
Cambridge, UK.
DOI: 10.1093/fampra/cmx088
PMCID: PMC5892172
PMID: 28973393 [Indexed for MEDLINE]
DOI: 10.1016/j.pedhc.2016.01.003
PMCID: PMC4976043
PMID: 26861574 [Indexed for MEDLINE]
Hafferty JD(1), Campbell AI(2), Navrady LB(3), Adams MJ(3), MacIntyre D(3),
Lawrie SM(3), Nicodemus K(4), Porteous DJ(5), McIntosh AM(6).
Author information:
(1)Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh,
Edinburgh EH10 5HF, UK. Electronic address: jonathan.hafferty@ed.ac.uk.
(2)Generation Scotland, Centre for Genomics and Experimental Medicine, Institute
for Genetics and Molecular Medicine, Western General Hospital, University of
Edinburgh, Edinburgh EH4 2XU, UK.
(3)Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh,
Edinburgh EH10 5HF, UK.
(4)Generation Scotland, Centre for Genomics and Experimental Medicine, Institute
for Genetics and Molecular Medicine, Western General Hospital, University of
Edinburgh, Edinburgh EH4 2XU, UK; Institute for Genetics and Molecular Medicine,
Western General Hospital, University of Edinburgh1, Edinburgh EH4 2XU, UK.
(5)Generation Scotland, Centre for Genomics and Experimental Medicine, Institute
for Genetics and Molecular Medicine, Western General Hospital, University of
Edinburgh, Edinburgh EH4 2XU, UK; Institute for Genetics and Molecular Medicine,
Western General Hospital, University of Edinburgh1, Edinburgh EH4 2XU, UK; Centre
for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7
George Square, EH8 9JZ, UK.
(6)Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh,
Edinburgh EH10 5HF, UK; Centre for Cognitive Ageing and Cognitive Epidemiology,
University of Edinburgh, 7 George Square, EH8 9JZ, UK.
Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.jclinepi.2017.10.013
PMCID: PMC5808931
PMID: 29097340
Author information:
(1)Behaviour and Health Research Unit, University of Cambridge, UK.
(2)Primary Care Unit, Department of Public Health and Primary Care, University of
Cambridge, UK.
(3)Behavioural Science Group, University of Cambridge, UK.
© 2015 The Authors. British Journal of Health Psychology published by John Wiley
& Sons Ltd on behalf of the British Psychological Society.
DOI: 10.1111/bjhp.12152
PMCID: PMC5014219
PMID: 26264673 [Indexed for MEDLINE]
Patzer RE(1)(2), Serper M(3), Reese PP(4), Przytula K(5), Koval R(6), Ladner
DP(7), Levitsky JM(7), Abecassis MM(7), Wolf MS(8).
Author information:
(1)Division of Transplantation, Department of Surgery, Emory University School of
Medicine, Atlanta, GA, USA. rpatzer@emory.edu.
(2)Department of Epidemiology, Rollins School of Public Health, Emory University
School of Medicine, Atlanta, GA, USA. rpatzer@emory.edu.
(3)Division of Gastroenterology and Hepatology, Department of Medicine, Perelman
School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
(4)Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman
School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
(5)Health Literacy and Learning Program, Division of General Internal Medicine,
Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
(6)Division of Transplantation, Department of Surgery, Emory University School of
Medicine, Atlanta, GA, USA.
(7)Comprehensive Transplant Center (CTC), Northwestern University Transplant
Outcomes Research Collaborative (NUTORC), Northwestern University Feinberg School
of Medicine, Chicago, IL, USA.
(8)Division of General Internal Medicine and Geriatrics, Department of Medicine,
Northwestern University School of Medicine, Chicago, IL, USA.
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
DOI: 10.1111/ctr.12821
PMCID: PMC5061615
PMID: 27447351 [Indexed for MEDLINE]
Sontakke S(1), Budania R(1), Bajait C(1), Jaiswal K(1), Pimpalkhute S(1).
Author information:
(1)Department of Pharmacology, Government Medical College, Nagpur, Maharashtra,
India.
DOI: 10.4103/0253-7613.169597
PMCID: PMC4689023
PMID: 26729961 [Indexed for MEDLINE]
Author information:
(1)Department of Preventive Medicine, Regional Cardiocerebrovascular Disease
Center, Kyungpook National University Hospital.
(2)Department of Preventive Medicine, Kyungpook National University School of
Medicine, Daegu.
(3)Department of Preventive Medicine and Institute of Health Sciences, Gyeongsang
National University School of Medicine; Department of Preventive Medicine,
Regional Cardiocerebrovascular Disease Center, Gyeongsang National University
Hospital, Jinju.
(4)Department of Emergency Medicine, CHA Gumi Medical Center, CHA University,
Gumi, Korea.
DOI: 10.2147/PPA.S114529
PMCID: PMC5047725
PMID: 27729776
Analgesic use among the Brazilian population: Results from the National Survey on
Access, Use and Promotion of Rational Use of Medicines (PNAUM).
da Silva Dal Pizzol T(1)(2), Turmina Fontanella A(2), Cardoso Ferreira MB(3),
Dâmaso Bertoldi A(4), Boff Borges R(2), Serrate Mengue S(2).
Author information:
(1)Department of Production and Control of Medicines, School of Pharmacy, Federal
University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.
(2)Graduate Program in Epidemiology, School of Medicine, Federal University of
Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.
(3)Department of Pharmacology, Institute for Basic Health Sciences, Federal
University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.
(4)Graduate Program in Epidemiology, Federal University of Pelotas (UFPEL),
Pelotas, Rio Grande do Sul, Brazil.
Erratum in
PLoS One. 2019 Apr 18;14(4):e0216005.
DOI: 10.1371/journal.pone.0214329
PMCID: PMC6428399
PMID: 30897156
714. BMJ Sex Reprod Health. 2018 Jul 18. pii: bmjsrh-2018-200102. doi:
10.1136/bmjsrh-2018-200102. [Epub ahead of print]
Author information:
(1)Ibis Reproductive Health, Oakland, California, USA.
(2)The Institute for the Study of Human Rights, Columbia University, New York
City, New York, USA.
DOI: 10.1136/bmjsrh-2018-200102
PMCID: PMC6225793
PMID: 30021794
715. Int J Nurs Pract. 2018 Feb;24(1). doi: 10.1111/ijn.12616. Epub 2017 Dec 5.
Author information:
(1)Department of Nursing, Kyungsung University, Busan, South Korea.
(2)Department of Nursing, Gyeongnam National University of Science and
Technology, Jinju, South Korea.
(3)College of Nursing, Institute of Health Science, Gyeongsang National
University, Jinju, South Korea.
DOI: 10.1111/ijn.12616
PMCID: PMC5814914
PMID: 29205693 [Indexed for MEDLINE]
El Hamouchi A(1), Daoui O(1)(2), Ait Kbaich M(1)(2), Mhaidi I(1)(2), El Kacem
S(1)(3), Guizani I(4), Sarih M(1), Lemrani M(1).
Author information:
(1)Laboratory of Parasitology and Vector-Borne-Diseases, Institut Pasteur du
Maroc, Casablanca, Morocco.
(2)Molecular Genetics and Immunophysiopathology Research Team, Health and
Environment Laboratory, Hassan II University of Casablanca, Aïn Chock Faculty of
Sciences, Morocco.
(3)Laboratory of Biology and Health, Faculty of Sciences Ben M'Sik, Hassan II
University, Casablanca, Morocco.
(4)Molecular Epidemiology and Experimental Pathology (MEEP)/ LR16IPT04, Institut
Pasteur de Tunis, Université de Tunis El Manar, Tunisia.
DOI: 10.1371/journal.pntd.0007321
PMCID: PMC6474635
PMID: 30964864 [Indexed for MEDLINE]
Kaye AD, Jones MR(1), Kaye AM, Ripoll JG(2), Jones DE(3), Galan V(4), Beakley
BD(2), Calixto F(2), Bolden JL(5), Urman RD, Manchikanti L.
Author information:
(1)Department of Anesthesiology, Louisiana State University Health New Orleans.
(2)Department of Anesthesiology, Tulane School of Medicine, New Orleans, LA.
(3)Dept. of Anesthesiology, Louisiana State University Health.
(4)Georgia Pain Care, Atlanta, GA.
(5)Louisiana State University.
Chronic pain and prescription opioid abuse are extremely prevalent in the United
States and worldwide. The consequences of opioid misuse can be life-threatening
with significant morbidity and mortality, exacting a heavy toll on patients,
physicians, and society. The risk for misuse of prescribed opioids is much higher
in patients with chronic pain, especially those with concurrent substance use and
/or mental health disorders. Several reasons can account for the occurrence of
opioid abuse and misuse, including self-medication, use for reward, compulsive
use related to addiction, and diversion for profit. There is a need, therefore,
for therapeutic approaches that balance treating chronic pain, while minimizing
risks for opioid abuse, misuse, and diversion. Chronic opioid therapy for chronic
non-cancer pain has seen a dramatic increase throughout the past 2 decades in
conjunction with associated increases in the abuse of prescribed opioids and
accidental opioid overdoses. Consequently, a validated screening instrument that
provides an effective and rational method for selecting patients for opioid
therapy, predicting risk, and identifying problems once they have arisen, could
be of enormous benefit in clinical practice. An instrument as such has the
potential to attenuate the risk of iatrogenic addiction. Despite the recent
introduction of various screening strategies and instruments, no single test or
instrument can reliably and accurately predict those patients unsuitable for
opioid therapy or pinpoint those requiring heightened degrees of surveillance and
monitoring throughout their therapy. Current opioid abuse screening tactics
include assessing premorbid and comorbid substance abuse; assessing aberrant
drug-related behaviors; stratification of risk factors; and utilizing opioid
assessment screening tools. Several authors have contributed numerous screening
tools and instruments to aid the assessment of appropriate opioid therapy.
Additional essential measures include urine drug testing, prescription practice
monitoring programs, opioid treatment agreements, and implementing universal
precautions. Presently accepted recommendations consist of a combination of
strategies designed to stratify risk, to identify and to understand aberrant
drug-related behaviors, and to tailor treatments accordingly. This manuscript,
Part 2 of a 2 part update, builds on the 2012 opioid guidelines published in Pain
Physician, and the 2016 guidelines released by the Centers for Disease Control
and Prevention. It reviews screening, monitoring, and addressing opioid abuse and
misuse in patients with chronic non-cancer pain. Opioids, misuse, abuse, chronic
pain, prevalence, risk assessment, risk management, drug monitoring, aberrant
drug-related behavior.
Bonnal A(1), Dehon A(1), Nagot N(2), Macioce V(2), Nogue E(2), Morau E(1).
Author information:
(1)Department of Anaesthesiology, Arnaud de Villeneuve University Hospital,
Montpellier, France.
(2)Clinical Research and Epidemiology Unit, Medical Information Department,
Montpellier University Hospital, Montpellier, France.
DOI: 10.1111/anae.13406
PMID: 26931110 [Indexed for MEDLINE]
719. BMJ Open Respir Res. 2015 Jun 23;2(1):e000078. doi: 10.1136/bmjresp-2014-
000078.
eCollection 2015.
Harakeh S(1), Almatrafi M(2), Ungapen H(3), Hammad R(4), Olayan F(5), Hakim R(6),
Ayoub M(7), Bakhsh N(5), Almasaudi SB(8), Barbour E(9), Bahijri S(10), Azhar
E(1), Damanhouri G(10), Qari Y(11), Kumosani T(12), Harakeh Z(13), Ahmad MS(14),
Cals JW.
Author information:
(1)Special Infectious Agents Unit , King Fahd Medical Research Center, King
Abdulaziz University , Jeddah , Saudi Arabia.
(2)Obstetrics and Gynecology Department, King Abdulaziz Medical City, National
Guard Health Affair, Riyadh , Saudi Arabia.
(3)Manchester , UK.
(4)Department of Pediatric , King Fahad Armed Forces Hospital , Jeddah , Saudi
Arabia.
(5)Medical School, Umm Alqura University, Makkah , Saudi Arabia.
(6)Department of Family Medicine, National Guard Hospital , Jeddah , Saudi
Arabia.
(7)Department of Pediatric, National Guard Hospital, Jeddah, Saudi Arabia.
(8)Biology Department, King Abdulaziz University , Jeddah , Saudi Arabia.
(9)Department of Animal and Veterinary Sciences, American University of Beirut,
Lebanon; Adjunct to Biochemistry Department, Faculty of Science and Production of
Bioproducts for Industrial Application Research Group, King Abdulaziz Univeristy,
Jeddah , Saudi Arabia.
(10)King Fahd Medical Research Center , Jeddah , Saudi Arabia.
(11)Department of Gastroenterology, Faculty of Medicine, King Abdulaziz
University, Jeddah, Saudi Arabia.
(12)Biochemistry Department, Faculty of Science and Experimental Biochemistry
Unit, King Fahd Medical Research Center , Jeddah , Saudi Arabia.
(13)Department of Interdisciplinary Social Science, Utrecht University, Utrecht,
The Netherlands.
(14)Drug Metabolism Unit, King Fahd Medical Research Center, Jeddah, Saudi
Arabia.
(15)Department of Family Medicine, School of Primary Care and Public Health
(CAPHRI), Maastricht University, Maastricht, The Netherlands.
Erratum in
BMJ Open Respir Res. 2015;2(1). pii: bmjresp-2014-000078corr1. doi:
10.1136/bmjresp-2014-000078corr1. Cals, JochenW L [corrected to Cals, Jochen W
L].
DOI: 10.1136/bmjresp-2014-000078
PMCID: PMC4488607
PMID: 26175907
Are Expectations Too High for Transitioning Adolescents With Inflammatory Bowel
Disease? Examining Adult Medication Knowledge and Self-Management Skills.
Author information:
(1)*Division of Gastroenterology and Nutrition, Boston Children's Hospital,
Harvard Medical School †Clinical Research Center, Boston Children's Hospital
‡Bouve School of Health Sciences, Northeastern University §Division of
Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School,
Boston, MA.
Comment in
J Pediatr Gastroenterol Nutr. 2016 Nov;63(5):451-452.
DOI: 10.1097/MPG.0000000000001299
PMCID: PMC5331613
PMID: 27280748 [Indexed for MEDLINE]
721. SSM Popul Health. 2017 Dec 9;4:144-152. doi: 10.1016/j.ssmph.2017.11.010.
eCollection 2018 Apr.
Vie TL(1), Hufthammer KO(2), Holmen TL(3), Meland E(4), Breidablik HJ(1).
Author information:
(1)Helse Førde HF/Førde Health Trust, postboks 1000, 6807 Førde, Norway.
(2)Centre for Clinical Research, Haukeland University Hospital, Norway.
(3)HUNT Research Centre, Department of Public health and General Practice,
Faculty of Medicine, Norwegian University of Science and Technology, Norway.
(4)Department of Global Public Health and Primary Care, University of Bergen,
Norway.
DOI: 10.1016/j.ssmph.2017.11.010
PMCID: PMC5769112
PMID: 29349283
Gallagher BD(1), Moise N(1), Haerizadeh M(1), Ye S(1), Medina V(1), Kronish
IM(2).
Author information:
(1)Center for Behavioral Cardiovascular Health, Columbia University Medical
Center, New York, New York.
(2)Center for Behavioral Cardiovascular Health, Columbia University Medical
Center, New York, New York. Electronic address: ik2293@columbia.edu.
DOI: 10.1016/j.cardfail.2016.11.001
PMCID: PMC5380538
PMID: 27818309 [Indexed for MEDLINE]
Morrissey EC(1)(2), Casey M(3), Glynn LG(4), Walsh JC(2), Molloy GJ(1).
Author information:
(1)Medication Adherence Across the Lifespan Research Group, School of Psychology,
National University of Ireland Galway, Galway, Ireland.
(2)mHealth Research Group, School of Psychology, National University of Ireland
Galway, Galway, Ireland.
(3)School of Medicine, National University of Ireland Galway, Galway, Ireland.
(4)Graduate Entry Medical School, University of Limerick, Limerick, Ireland.
DOI: 10.2147/PPA.S145647
PMCID: PMC5957057
PMID: 29785096
Wilson IB(1), Lee Y(2), Michaud J(2), Fowler FJ Jr(3), Rogers WH(4).
Author information:
(1)Department of Health Services, Policy & Practice, Brown University School of
Public Health, Box G-121-7, 121 South Main St., Providence, RI, 02912, USA.
ira_wilson@brown.edu.
(2)Department of Health Services, Policy & Practice, Brown University School of
Public Health, Box G-121-7, 121 South Main St., Providence, RI, 02912, USA.
(3)Center for Survey Research, University of Massachusetts, Boston, MA, USA.
(4)Center for Health Solutions, Tufts Medical Center, Boston, MA, USA.
DOI: 10.1007/s10461-016-1406-x
PMCID: PMC5071118
PMID: 27098408 [Indexed for MEDLINE]
Let Visuals Tell the Story: Medication Adherence in Patients with Type II
Diabetes Captured by a Novel Ingestion Sensor Platform.
Author information:
(1)University of California, San Diego, School of Medicine, La Jolla, CA, United
States. shbrowne@ucsd.edu.
DOI: 10.2196/mhealth.4292
PMCID: PMC4713908
PMID: 26721413
Author information:
(1)1 Evelina London Children's Hospital, Guy's and St Thomas' NHS Trust, London,
UK.
(2)2 School of Psychology, University of East London, London, UK.
(3)3 Respiratory Paediatrics, Royal Brompton Hospital, London, UK.
This study explored the experiences of adolescents and their caregivers regarding
adherence to inhaled corticosteroids which are assessed through an electronic
monitoring device (EMD). These devices are increasingly being used for assessing
medication adherence, yet there is little information about patient's experience
of these tools. Semi-structured interviews were conducted with eight adolescents
with severe asthma, aged 11-15 years, who were electronically monitored as part
of their care, along with their caregivers. Interviews were analysed using
thematic analysis. Three themes were identified: 'they were trying to help me get
better', 'checking up and catching out' and 'who is responsible?' The themes
highlighted differences in priorities between participant groups, the impact of
monitoring on the healthcare relationship and the dilemma of transferring
responsibility for asthma management to adolescents. The findings suggest it is
important for healthcare professionals to engage with patient's preferences and
priorities when introducing EMDs.
DOI: 10.1177/1367493517753082
PMID: 29325420 [Indexed for MEDLINE]
727. Brain Sci. 2019 Jul 16;9(7). pii: E166. doi: 10.3390/brainsci9070166.
Cobb S(1), Bazargan M(2)(3)(4), Smith J(2), Del Pino HE(5)(6), Dorrah K(3),
Assari S(7).
Author information:
(1)School of Nursing, Charles R Drew University of Medicine and Science, Los
Angeles, CA 90059, USA.
(2)Department of Family Medicine, College of Medicine, Charles R Drew University
of Medicine and Science, Los Angeles, CA 90059, USA.
(3)Department of Public Health, Charles R Drew University of Medicine and
Science, Los Angeles, CA 90059, USA.
(4)Department of Family Medicine, University of California, Los Angeles (UCLA),
Los Angeles, CA 90095, USA.
(5)Department of Psychiatry and Human Behavior, College of Medicine, Charles R
Drew University of Medicine and Science, Los Angeles, CA 90059, USA.
(6)Department of Psychiatry and Biobehavioral Sciences, University of California,
Los Angeles (UCLA), Los Angeles, CA 90095, USA.
(7)Department of Family Medicine, College of Medicine, Charles R Drew University
of Medicine and Science, Los Angeles, CA 90059, USA. shervinassari@cdrewu.edu.
Purpose: This study explored demographic, social, behavioral, and health factors
associated with current marijuana use (MU) among African American older adults
who were residing in economically challenged areas of south Los Angeles. Methods:
This community-based study recruited a consecutive sample of African American
older adults (n = 340), age ≥ 55 years, residing in economically challenged areas
of South Los Angeles. Interviews were conducted to collect data. Demographics
(age and gender), socioeconomic status (educational attainment, income, and
financial strain), marital status, living alone, health behaviors (alcohol
drinking and cigarette smoking), health status (number of chronic medical
conditions, body mass index, depression, and chronic pain), and current MU were
collected. Logistic regression was used to analyze the data. Results: Thirty
(9.1%) participants reported current MU. Age, educational attainment, chronic
medical conditions, and obesity were negatively associated with current MU.
Gender, income, financial strain, living alone, marital status, smoking
cigarettes, drinking alcohol, depression, and pain did not correlate with MU.
Conclusion: Current MU is more common in younger, healthier, less obese, less
educated African American older adults. It does not seem that African American
older adults use marijuana for the self-medication of chronic disease, pain, or
depression. For African American older adults, MU also does not co-occur with
cigarette smoking and alcohol drinking. These results may help clinicians who
provide services for older African Americans in economically challenged urban
areas.
DOI: 10.3390/brainsci9070166
PMCID: PMC6681052
PMID: 31315249
What Really Happens in the Home: The Medication Environment of Urban, Minority
Youth.
Author information:
(1)Asthma and Allergy Center, Bloomingdale, Ill; Department of Pediatrics,
University of Illinois at Chicago, Chicago, Ill. Electronic address:
pappalardo.andrea@gmail.com.
(2)Department of Preventative Medicine, Rush University Medical Center, Chicago,
Ill.
(3)Department of Pediatrics, University of Illinois at Chicago, Chicago, Ill.
BACKGROUND: Asthma disproportionately affects minority youth. Understanding the
home medication environment and its relation to medication adherence can shape
interventions to improve health outcomes.
OBJECTIVE: The objective of this study was to describe the asthma medication
environment in the homes of urban minority youth and to determine predictors of
medication use and technique in this population.
METHODS: Baseline data from 2 cohorts of minority youth with asthma in Chicago
were combined for cross-sectional analysis. Bilingual research assistants (RAs)
collected data in the home. RAs asked caregivers and children to self-report
medications using pictures and observed children's asthma medications and inhaler
technique.
RESULTS: The sample contained 175 mainly Latino youth (85.6%) ranging from 5 to
18 years old. Most were on public insurance (80%) and had uncontrolled asthma by
self-report (89.7%). Only 27.4% had a spacer, 74.9% had a quick relief medicine,
and 48.6% had any controller medicine. RA observations of controllers agreed with
children (36%) and parental self-report (42.3%) but did not match the specific
observed controllers. Children reported less parental help with medications (43%)
than their parents (58.1%). One child was able to properly demonstrate 100% of
the inhaler steps and 35.6% achieved >70% of inhaler steps. A better medication
technique was associated with having a controller (b = 12.2, SE = 3.0,
P < .0001), quick reliever (b = 8.05, SE = 3.5, P = .023), and a spacer (b = 9.3,
SE = 3.54, P = .009).
CONCLUSIONS: This rigorous evaluation of the home medication environment of
high-risk youth demonstrated that many families lack critical medications,
devices, and a technique for proper management of asthma.
DOI: 10.1016/j.jaip.2016.09.046
PMCID: PMC5423821
PMID: 27914817 [Indexed for MEDLINE]
Connecting the dots between breast cancer, obesity and alcohol consumption in
middle-aged women: ecological and case control studies.
Miller ER(1), Wilson C(2)(3), Chapman J(2), Flight I(2), Nguyen AM(4), Fletcher
C(2), Ramsey I(2).
Author information:
(1)College of Medicine and Public Health, Flinders University, Adelaide,
Australia. emma.miller@flinders.edu.au.
(2)Flinders Centre for Innovation in Cancer, Flinders University , Adelaide,
Australia.
(3)Cancer Council of South Australia, Adelaide, Australia.
(4)College of Medicine and Public Health, Flinders University, Adelaide,
Australia.
DOI: 10.1186/s12889-018-5357-1
PMCID: PMC5889566
PMID: 29625601 [Indexed for MEDLINE]
730. Biomed Res Int. 2015;2015:968786. doi: 10.1155/2015/968786. Epub 2015 Nov 10.
Cinosi E(1), Martinotti G(1), Simonato P(2), Singh D(3), Demetrovics Z(4),
Roman-Urrestarazu A(5), Bersani FS(6), Vicknasingam B(3), Piazzon G(2), Li JH(7),
Yu WJ(7), Kapitány-Fövény M(8), Farkas J(9), Di Giannantonio M(10), Corazza O(6).
Author information:
(1)Centre for Clinical & Health Research Services, School of Life and Medical
Sciences, University of Hertfordshire, College Lane Campus, Hatfield, Herts AL10
9AB, UK ; Department of Neuroscience, Imaging and Clinical Sciences, Gabriele
D'Annunzio University, Chieti, Italy.
(2)Centre for Clinical & Health Research Services, School of Life and Medical
Sciences, University of Hertfordshire, College Lane Campus, Hatfield, Herts AL10
9AB, UK.
(3)Centre for Drug Research, Universiti Sains, Penang, Malaysia.
(4)Institute of Psychology, Eötvös Loránd University, Budapest, Hungary.
(5)London School of Economics and Political Science, LSE Health and Social Care,
London, UK ; Department of Psychiatry, University of Cambridge, Cambridge, UK.
(6)Centre for Clinical & Health Research Services, School of Life and Medical
Sciences, University of Hertfordshire, College Lane Campus, Hatfield, Herts AL10
9AB, UK ; Department of Neurology and Psychiatry, Sapienza University of Rome,
Rome, Italy.
(7)School of Pharmacy and Ph.D. Program in Toxicology, Kaohsiung Medical
University, Kaohsiung, Taiwan.
(8)Institute of Psychology, Eötvös Loránd University, Budapest, Hungary ; Faculty
of Health Sciences, Semmelweis University, Budapest, Hungary ; Nyírő Gyula
Hospital, National Institute of Psychiatry and Addictions, Budapest, Hungary.
(9)Institute of Psychology, Eötvös Loránd University, Budapest, Hungary ; Nyírő
Gyula Hospital, National Institute of Psychiatry and Addictions, Budapest,
Hungary.
(10)Department of Neuroscience, Imaging and Clinical Sciences, Gabriele
D'Annunzio University, Chieti, Italy.
DOI: 10.1155/2015/968786
PMCID: PMC4657101
PMID: 26640804 [Indexed for MEDLINE]
Author information:
(1)Loyola University Chicago.
(2)Loyola University Chicago gholmbe@luc.edu.
© The Author 2015. Published by Oxford University Press on behalf of the Society
of Pediatric Psychology. All rights reserved. For permissions, please e-mail:
journals.permissions@oup.com.
DOI: 10.1093/jpepsy/jsv044
PMCID: PMC4626750
PMID: 26002195 [Indexed for MEDLINE]
Kamaradova D(1), Latalova K(1), Prasko J(1), Kubinek R(1), Vrbova K(1), Mainerova
B(1), Cinculova A(1), Ociskova M(1), Holubova M(2), Smoldasova J(1), Tichackova
A(1).
Author information:
(1)Department of Psychiatry, University Hospital Olomouc.
(2)Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech
Republic.
DOI: 10.2147/PPA.S99136
PMCID: PMC4966500
PMID: 27524884
733. Ci Ji Yi Xue Za Zhi. 2019 Apr-Jun;31(2):73-80. doi: 10.4103/tcmj.tcmj_177_18.
Author information:
(1)Department of Community Medicine, Maulana Azad Medical College, New Delhi,
India.
DOI: 10.4103/tcmj.tcmj_177_18
PMCID: PMC6450154
PMID: 31007485
Rhead R(1), Masimirembwa C(2), Cooke G(3), Takaruza A(4), Nyamukapa C(4),
Mutsimhi C(2), Gregson S(1).
Author information:
(1)Imperial College London, Department of Infectious Disease Epidemiology,
London, United Kingdom.
(2)African Institute of Biomedical Research and Technology, Harare, Zimbabwe.
(3)Imperial College London, Department of Medicine, London, United Kingdom.
(4)Biomedical Research and Training Institute, Harare, Zimbabwe.
DOI: 10.1371/journal.pone.0167852
PMCID: PMC5156419
PMID: 27973550 [Indexed for MEDLINE]
Insel KC(1), Einstein GO(2), Morrow DG(3), Koerner KM(1), Hepworth JT(1).
Author information:
(1)College of Nursing, University of Arizona, Tucson, Arizona.
(2)Department of Psychology, Furman University, Greenville, South Carolina.
(3)Department of Educational Psychology, University of Illinois, Urbana,
Illinois.
© 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics
Society.
DOI: 10.1111/jgs.14032
PMCID: PMC4806399 [Available on 2017-03-01]
PMID: 27000329 [Indexed for MEDLINE]
Stressors may compromise medication adherence among adults with diabetes and low
socioeconomic status.
Author information:
(1)Vanderbilt University Medical Center, Nashville, TN, USA
chandra.osborn@vanderbilt.edu.
(2)Vanderbilt University Medical Center, Nashville, TN, USA.
(3)University of Connecticut Health Center, Farmington, CT, USA.
(4)Tufts University School of Medicine, Boston, MA, USA Baystate Medical Center,
Springfield, MA, USA.
DOI: 10.1177/0193945914524639
PMCID: PMC4143498
PMID: 24569697 [Indexed for MEDLINE]
Wagner GJ(1), Ghosh-Dastidar B(2), Robinson E(2), Ngo VK(2), Glick P(2), Mukasa
B(3), Musisi S(4), Akena D(4).
Author information:
(1)RAND Corporation, 1776 Main St., Santa Monica, CA, 90407, USA.
gwagner@rand.org.
(2)RAND Corporation, 1776 Main St., Santa Monica, CA, 90407, USA.
(3)Mildmay Uganda, Kampala, Uganda.
(4)Department of Psychiatry, Makerere University, Kampala, Uganda.
With depression known to impede HIV care adherence and retention, we examined
whether depression alleviation improves these disease management behaviors. A
sample of 1028 depressed HIV clients in Uganda enrolled in a cluster randomized
controlled trial of two depression care models, and were surveyed over 12 months.
Serial regression analyses examined whether depression alleviation was associated
with self-reported antiretroviral therapy (ART) adherence and clinic attendance
at month 12, and whether these relationships were mediated by self-efficacy and
motivation. Among those with major depression, depression alleviation was
associated with better ART adherence and clinic attendance at month 12; these
relationships were fully mediated by self-efficacy at month 12, while adherence
motivation partially mediated the relationship between depression alleviation and
ART adherence. When both mediators were entered simultaneously, only
self-efficacy was a significant predictor and still fully mediated the
relationship between depression alleviation and adherence. These findings suggest
that depression alleviation benefits both ART adherence and clinic attendance, in
large part through improved confidence and motivation to engage in these disease
management behaviors.
DOI: 10.1007/s10461-016-1500-0
PMCID: PMC5250618
PMID: 27438460 [Indexed for MEDLINE]
738. J Clin Pharm Ther. 2016 Jun;41(3):256-9. doi: 10.1111/jcpt.12360. Epub 2016
Mar
4.
Medication adherence may be more important than other behaviours for optimizing
glycaemic control among low-income adults.
WHAT IS KNOWN: Patients with type 2 diabetes mellitus (T2DM) are required to
perform multiple self-care behaviours to achieve and maintain optimal glycaemic
control (HbA1c), which prevents complications and premature mortality. Patients
with T2DM and low socioeconomic status (SES) are more likely to have suboptimal
HbA1c, often due to being less adherent to recommended self-care activities than
their higher-SES counterparts.
OBJECTIVE: Although studies support performing certain diabetes self-care
behaviours for optimizing glycaemic control, there is limited research on the
relative importance of each behaviour for this purpose. Identifying what
behaviours are most important for HbA1c among low-SES patients with T2DM would be
particularly useful for informing policy and intervention efforts for this
high-risk group.
METHODS: In a cross-sectional study of 314 adults with T2DM and low SES, we used
the Summary of Diabetes Self-Care Activities to assess self-care behaviours and
multivariate models to test which behaviours were associated with lower HbA1c.
RESULTS AND DISCUSSION: Only medication adherence was significantly associated
with lower HbA1c after adjusting for the other self-care behaviours (β = -0·14, P
= 0·028) and further adjusting for demographic and diabetes characteristics (β =
-0·16, P = 0·024).
WHAT IS NEW: Medication adherence may be the most important self-care behaviour
for glycaemic control among adults with T2DM and low SES.
CONCLUSION: Focused efforts to improve medication adherence among low-SES patient
populations may improve glycaemic control.
DOI: 10.1111/jcpt.12360
PMCID: PMC4871756
PMID: 26939721 [Indexed for MEDLINE]
McCulley C(1)(2), Katz P(1)(2), Trupin L(1)(2), Yelin EH(1)(2), Barton JL(3)(4).
Author information:
(1)From the University of California, San Francisco, San Francisco, California;
Oregon Health & Science University; VA Portland Health Care System, Portland,
Oregon, USA.
(2)C. McCulley, MD, Rheumatology Fellow, Oregon Health & Science University; P.
Katz, PhD, Professor, Division of Rheumatology, University of California, San
Francisco; L. Trupin, MPH, Epidemiologist, Division of Rheumatology, University
of California, San Francisco; E.H. Yelin, PhD, Professor Emeritus, Division of
Rheumatology, University of California, San Francisco, J.L. Barton, MD, Associate
Professor, Division of Rheumatology, Oregon Health & Science University, and VA
Portland Health Care System.
(3)From the University of California, San Francisco, San Francisco, California;
Oregon Health & Science University; VA Portland Health Care System, Portland,
Oregon, USA. bartoje@ohsu.edu.
(4)C. McCulley, MD, Rheumatology Fellow, Oregon Health & Science University; P.
Katz, PhD, Professor, Division of Rheumatology, University of California, San
Francisco; L. Trupin, MPH, Epidemiologist, Division of Rheumatology, University
of California, San Francisco; E.H. Yelin, PhD, Professor Emeritus, Division of
Rheumatology, University of California, San Francisco, J.L. Barton, MD, Associate
Professor, Division of Rheumatology, Oregon Health & Science University, and VA
Portland Health Care System. bartoje@ohsu.edu.
DOI: 10.3899/jrheum.171339
PMCID: PMC6364826
PMID: 30219761
Author information:
(1)Department of Family Medicine, University of Michigan, 1018 Fuller Street, Ann
Arbor, MI, 48104-1213, USA, aikensj@umich.edu.
Comment in
J Gen Intern Med. 2015 Mar;30(3):346.
OBJECTIVE: The purpose of this study was to investigate the potential benefits
for medication adherence of integrating a patient-selected support person into an
automated diabetes telemonitoring and self-management program, and to determine
whether these benefits vary by patients' baseline level of psychological
distress.
STUDY DESIGN: The study was a quasi-experimental patient preference trial.
METHODS: The study included patients with type 2 diabetes who participated in
three to six months of weekly automated telemonitoring via interactive voice
response (IVR) calls, with the option of designating a supportive relative or
friend to receive automated updates on the patient's health and self-management,
along with guidance regarding potential patient assistance. We measured long-term
medication adherence using the four-point Morisky Medication Adherence Scale
(MMAS-4, possible range 0-4), weekly adherence with an IVR item, and
psychological distress at baseline with the Mental Composite Summary (MCS) of the
SF-12.
RESULTS: Of 98 initially nonadherent patients, 42% opted to involve a support
person. Participants with a support person demonstrated significantly greater
improvement in long-term adherence than those who participated alone (linear
regression slopes: -1.17 vs. -0.57, respectively, p =0.001). Among distressed
patients in particular, the odds of weekly nonadherence tended to decrease 25%
per week for those with a support person (p =0.030), yet remained high for those
who participated alone (p =0.820).
CONCLUSIONS: Despite their multiple challenges in illness self-management,
patients with diabetes who are both nonadherent and psychologically distressed
may benefit by the incorporation of a support person when they receive assistance
via automated telemonitoring.
DOI: 10.1007/s11606-014-3101-9
PMCID: PMC4351288
PMID: 25421436 [Indexed for MEDLINE]
Stirratt MJ(1), Dunbar-Jacob J(2), Crane HM(3), Simoni JM(4), Czajkowski S(5),
Hilliard ME(6), Aikens JE(7), Hunter CM(8), Velligan DI(9), Huntley K(10),
Ogedegbe G(11), Rand CS(12), Schron E(13), Nilsen WJ(14).
Author information:
(1)NIH/National Institute of Mental Health Division of AIDS Research, Bethesda,
MD USA.
(2)School of Nursing, University of Pittsburgh, Pittsburgh, PA USA.
(3)Division of Infectious Diseases, University of Washington, Seattle, WA USA.
(4)Department of Psychology, University of Washington, Seattle, WA USA.
(5)NIH/National Heart, Lung and Blood Institute, Bethesda, MD USA.
(6)Department of Pediatrics, Baylor College of Medicine, Houston, TX USA.
(7)Department of Family Medicine, University of Michigan, Ann Arbor, MI USA.
(8)NIH/National Institute of Diabetes and Digestive and Kidney Diseases,
Bethesda, MD USA.
(9)Health Science Center, University of Texas, San Antonio, TX USA.
(10)NIH/National Institute on Drug Abuse, Bethesda, MD USA.
(11)School of Medicine, New York University, New York, NY USA.
(12)School of Medicine, Johns Hopkins University, Baltimore, MD USA.
(13)NIH/National Eye Institute, Bethesda, MD USA.
(14)National Science Foundation, Arlington, VA USA.
DOI: 10.1007/s13142-015-0315-2
PMCID: PMC4656225
PMID: 26622919
Drieling RL, LaCroix AZ, Beresford SA, Boudreau DM, Kooperberg C, Heckbert SR.
© The Author 2016. Published by Oxford University Press on behalf of the Johns
Hopkins Bloomberg School of Public Health. All rights reserved. For permissions,
please e-mail: journals.permissions@oup.com.
DOI: 10.1093/aje/kwv446
PMCID: PMC4967595
PMID: 27402774 [Indexed for MEDLINE]
743. Transl Behav Med. 2016 Sep;6(3):457-68. doi: 10.1007/s13142-015-0348-6.
Damush TM(1), Myers L(2), Anderson JA(3), Yu Z(2), Ofner S(2), Nicholas G(2),
Kimmel B(2), Schmid AA(2), Kent T(3), Williams LS(2).
Author information:
(1)VA HSRD QUERI Center and HSRD CHIC Center, Indiana University School of
Medicine, Regenstrief Institute, Inc, Indianapolis, IN, USA. tdamush@iupui.edu.
(2)VA HSRD QUERI Center and HSRD CHIC Center, Indiana University School of
Medicine, Regenstrief Institute, Inc, Indianapolis, IN, USA.
(3)VA HSRD Coin Center, Michael DeBakey VAMC, Baylor College of Medicine,
Houston, TX, USA.
Erratum in
Transl Behav Med. 2016 Sep;6(3):469.
DOI: 10.1007/s13142-015-0348-6
PMCID: PMC4987603
PMID: 27349906 [Indexed for MEDLINE]
744. Schizophr Bull. 2015 May;41(3):584-96. doi: 10.1093/schbul/sbv015. Epub 2015
Mar
5.
Drake RJ(1), Nordentoft M(2), Haddock G(3), Arango C(4), Fleischhacker WW(5),
Glenthøj B(6), Leboyer M(7), Leucht S(8), Leweke M(9), McGuire P(10),
Meyer-Lindenberg A(9), Rujescu D(11), Sommer IE(12), Kahn RS(12), Lewis SW(13).
Author information:
(1)Manchester Academic Health Sciences Centre, Institute of Brain, Behaviour &
Mental Health, University of Manchester, Manchester, UK; Manchester Academic
Health Sciences Centre, Manchester Mental Health & Social Care NHS Trust,
Manchester, UK; richard.drake@manchester.ac.uk.
(2)Mental Health Centre Copenhagen, Faculty of Health and Medical Sciences,
University of Copenhagen, Copenhagen NV, Denmark;
(3)Manchester Academic Health Sciences Centre, Manchester Mental Health & Social
Care NHS Trust, Manchester, UK; Manchester Academic Health Sciences Centre,
School of Psychological Sciences, University of Manchester, Manchester, UK;
(4)Department of Child and Adolescent Psychiatry, Hospital General Universitario
Gregorio Marañón, CIBERSAM, IiSGM, School of Medicine, Universidad Complutense de
Madrid, Madrid, Spain;
(5)Department of Psychiatry and Psychotherapy, Medical University Innsbruck,
Innsbruck, Austria;
(6)Center for Neuropsychiatric Schizophrenia Research and Center for Clinical
Intervention and Neuropsychiatric Schizophrenia Research, Psychiatric Hospital
Center Glostrup, Faculty of Health and Medical Sciences, University of
Copenhagen, Glostrup, Denmark;
(7)INSERM U955, Laboratoire Psychopathologie et génétique des maladies mentales,
et AP-HP, DHU Pe-PSY, Pole de Psychiatrie et d'addictologie des Hôpitaux
Universitaires Henri Mondor, Université Paris-Est, Créteil, France;
(8)Department of Psychiatry and Psychotherapy, Technische Universität München,
München, Germany;
(9)Central Institute of Mental Health, Mannheim, Germany;
(10)King's College London, Institute of Psychiatry, London, UK;
(11)Psychiatry, Molecular and Clinical Neurobiology, Ludwig-Maximilians
University, München, München, Germany; Department of Psychiatry, University of
Halle, Halle, Germany;
(12)Department of Psychiatry, Brain Center Rudolf Magnus, UMC Utrecht, Utrecht,
The Netherlands.
(13)Manchester Academic Health Sciences Centre, Institute of Brain, Behaviour &
Mental Health, University of Manchester, Manchester, UK; Manchester Academic
Health Sciences Centre, Manchester Mental Health & Social Care NHS Trust,
Manchester, UK;
© The Author 2015. Published by Oxford University Press on behalf of the Maryland
Psychiatric Research Center. All rights reserved. For permissions, please email:
journals.permissions@oup.com.
DOI: 10.1093/schbul/sbv015
PMCID: PMC4393703
PMID: 25750247 [Indexed for MEDLINE]
Comparing the unmatched count technique and direct self-report for sensitive
health-risk behaviors in HIV+ adults.
Arentoft A(1)(2), Van Dyk K(2), Thames AD(2), Sayegh P(2), Thaler N(2), Schonfeld
D(3), LaBrie J(4), Hinkin CH(2)(3).
Author information:
(1)a Department of Psychology , California State University , Northridge , CA ,
USA.
(2)b Department of Psychiatry & Biobehavioral Sciences , University of
California-Los Angeles , Los Angeles , CA , USA.
(3)c Department of Psychology , West Los Angeles VA Healthcare Center , Los
Angeles , CA , USA.
(4)d Department of Psychology , Loyola Marymount University , CA , USA.
DOI: 10.1080/09540121.2015.1090538
PMCID: PMC5209753
PMID: 26856321 [Indexed for MEDLINE]
746. Patient Prefer Adherence. 2015 Oct 27;9:1505-15. doi: 10.2147/PPA.S85408.
eCollection 2015.
Author information:
(1)Faculty of Health and Life Sciences, Coventry University, Priory Street,
Coventry, UK.
(2)Primary Care and Health Sciences, Keele University, Staffordshire, UK.
DOI: 10.2147/PPA.S85408
PMCID: PMC4629975
PMID: 26604703
Fortin A(1), Morin V(1), Ramsay S(2), Gervais P(1), Bolduc S(2).
Author information:
(1)Department of Pediatrics, CHU de Québec - Université Laval, Québec, Québec.
(2)Division of Urology, CRCHU de Québec - Université Laval, Québec, Québec.
DOI: 10.1093/pch/pxx055
PMCID: PMC5804706
PMID: 29479229
Author information:
(1)Department of Psychiatry and Human Behavior, Warren Alpert Medical School of
Brown University; Weight Control and Diabetes Research Center, The Miriam
Hospital, Providence, RI.
(2)Department of Psychiatry and Human Behavior, Warren Alpert Medical School of
Brown University; Department of Psychological Sciences, Kent State University,
Kent, OH.
(3)Neuropsychology Section, Department of Psychiatry, University of Michigan, Ann
Arbor, MI, USA.
DOI: 10.2147/PPA.S127277
PMCID: PMC5359120
PMID: 28352161
Author information:
(1)South West Yorkshire Partnership NHS Foundation Trust, United Kingdom.
Electronic address: reed.cappleman@swyt.nhs.uk.
(2)Division of Health Research, Lancaster University, United Kingdom.
(3)Spectrum Centre for Mental Health Research, Lancaster University, United
Kingdom.
OBJECTIVES: Although many diagnosed with Bipolar Disorder (BD) choose to manage
their moods without medication at some point, their experiences of doing so are
not well understood. This paper aims to explore the processes by which people
manage bipolar moods without medication.
METHODS: Ten people diagnosed with BD who do not use medication were interviewed.
Analysing their accounts using grounded theory methods led to developing a model
of how they perceive the processes involved in managing moods without medication.
RESULTS: Participants engaged in repeated evaluative processes around their
strategies for managing moods. Some participants decided not to influence
elevated moods due to their perceived advantages. Participants ׳intentions and
actions were influenced by their perceptions of themselves and by the meanings
they attached to bipolar moods, which were in turn influenced by feedback from
others.
CONCLUSIONS: The complexity of the processes described by participants suggests
that traditional models of explaining non-adherence may over-simplify some
individuals ׳experiences. Future research could focus on identifying factors
predictive of successful attempts to manage moods without medication.
Professionals should place more emphasis on non-medication approaches in order to
increase engagement with people who do not use medication. This may involve
focussing on individual׳s longer-term goals rather than on modifying moods in
shorter-term. Conclusions are based on participants who had experienced
significant bipolar moods, but who largely seemed satisfied living without
medication.
LIMITATIONS: Future research should ascertain whether such processes apply to a
wider group of individuals who do not use medication for bipolar moods.
DOI: 10.1016/j.jad.2014.11.055
PMID: 25527994 [Indexed for MEDLINE]
OBJECTIVES: This review sought to identify the empirical evidence for the
application of models from sociocognitive theory, self-regulation theory, and
social support theory at predicting patient adherence to medications.
METHODS: A systematic review of the published literature (1990-2010) using
MEDLINE, EMBASE, Cochrane Library, CINAHL, and PsychINFO identified studies
examining the application of health psychology theory to adherence to medication
in adult patients. Two independent reviewers extracted data on medication,
indication, study population, adherence measure, theory, model, survey
instruments, and results. Heterogeneity in theoretical model specification and
empirical investigation precluded a meta-analysis of data.
RESULTS: Of 1756 unique records, 67 articles were included (sociocognitive = 35,
self-regulation = 21, social support = 11). Adherence was most commonly measured
by self-report (50 of 67). Synthesis of studies highlighted the significance (P ≤
0.05) of self-efficacy (17 of 19), perceived barriers (11 of 17), perceived
susceptibility (3 of 6), necessity beliefs (8 of 9), and medication concerns (7
of 8).
CONCLUSIONS: The results of this review provide a foundation for the development
of theory-led adherence-enhancing interventions that could promote sustainable
behavior change in clinical practice.
DOI: 10.1016/j.jval.2014.08.2671
PMID: 25498782 [Indexed for MEDLINE]
Author information:
(1)Department of Health Sciences, Faculty of Medicine, Lund University, Lund,
Sweden.
(2)Institute of Health and Care Sciences, The Sahlgrenska Academy, University of
Gothenburg, Gothenburg, Sweden.
(3)Institute of Health and Care Sciences, The Sahlgrenska Academy, University of
Gothenburg, Gothenburg, Sweden; Department of Medical and Health Sciences,
Linköping University, Linköping, Sweden.
DOI: 10.2147/POR.S58352
PMCID: PMC5045019
PMID: 27774027
Author information:
(1)Department of Medical Education, Medical Education Research Center, Isfahan
University of Medical Sciences, Isfahan, Iran.
(2)Department of Health Education and Health Promotion, School of Health, Isfahan
University of Medical Sciences, Isfahan, Iran.
(3)Department of Public Health, Faculty of Health, Qom University of Medical
Sciences, Qom, Iran.
(4)Department of Community Medicine, School of Medicine, Isfahan University of
Medical Sciences, Isfahan, Iran.
BACKGROUND: This study was aimed at developing and studying the scale of
self-efficacy in adherence to treatment in Iranian patients with hypertension.
METHODS: A mix-method study was conducted on the two stages: in the first phase,
a qualitative study was done using content analysis through deep and
semi-structured interviews. After data analysis, the draft of tool was prepared.
Items in the draft were selected based on the extracted concepts. In the second
phase, validity and reliability of the instrument were implemented using a
quantitative study. The prepared instrument in the first phase was studied among
612 participants. To test the construct validity and internal consistency,
exploratory factor analysis and Cronbach's alpha were used, respectively. To
study the validity of the final scale, the average score of self-efficacy in
patients with controlled hypertension were compared with patients with
uncontrolled hypertension.
RESULTS: In overall, 16 patients were interviewed. Twenty-six items were
developed to assess different concepts of self-efficacy. Concept-related items
were extracted from interviews to study the face validity of the tool from
patient's point of view. Four items were deleted because scored 0.79 in content
validity. The mean of questionnaire content validity was 0.85. Items were
collected in two factors with an eigenvalue >1. Four items were deleted with load
factor <0.4. Reliability was 0.84 for the entire instrument.
CONCLUSION: Self-efficacy scale in patients with hypertension is a valid and
reliable instrument that can effectively evaluate the self-efficacy in medication
adherence in the management of hypertension.
DOI: 10.4103/jehp.jehp_64_16
PMCID: PMC5651667
PMID: 29114551
Author information:
(1)Quality Use of Medicines and Pharmacy Research Centre, School of Pharmacy and
Medical Science, University of South Australia, Adelaide, Australia.
DOI: 10.1007/s40471-018-0176-6
PMCID: PMC6290698
PMID: 30596002
Conflict of interest statement: The authors declare that they have no conflicts
of interest.This article does not contain any studies with human or animal
subjects performed by any of the authors.
754. Int J Chron Obstruct Pulmon Dis. 2018 Jul 3;13:2065-2074. doi:
10.2147/COPD.S159726. eCollection 2018.
Author information:
(1)Faculty of Pharmacy, Division of Pharmacology and Pharmacotherapy, University
of Helsinki, Helsinki, Finland, juha.markus.heikkila@gmail.com.
(2)Hartola Pharmacy, Hartola, Finland, juha.markus.heikkila@gmail.com.
(3)Hyvinkää Willan Kehrä Pharmacy, Hyvinkää, Finland.
(4)The Association of Finnish Pharmacies, Helsinki, Finland.
(5)Tammela Pharmacy, Tammela, Finland.
Background and purpose: COPD is one of the leading causes of morbidity and
mortality worldwide. Although medication counseling interventions by pharmacists
have been found to support the management of COPD, little is known about
pharmacists' knowledge concerning COPD and regular practices and perceptions
concerning medication counseling of COPD patients. The purpose of this study was
to research these topics among Finnish community pharmacists.
Materials and methods: In January 2017, an electronic survey was e-mailed to
Finnish community pharmacies (n=741) via the Association of the Finnish
Pharmacies. One pharmacist from each pharmacy, preferably a specialist in asthma,
was invited to answer the survey.
Results: Completed responses were received from 263 pharmacists (response rate
=35%), of whom 196 pharmacists were specialists in asthma. Response rate among
asthma pharmacists was 42%. Pharmacists were positive about their role in
medication counseling and in support of the self-management of COPD patients.
COPD-related knowledge was self-assessed as being good and was on a good level in
respect of basic facts. However, almost half (46%) of the pharmacists did not
know that COPD is considered a national public health issue, and ~50% of the
pharmacists were not familiar with the current care guideline on COPD. Medication
counseling was found to be more medicinal product-driven and less advisory
concerning lifestyle changes such as smoking cessation and physical exercise.
Conclusion: Although the pharmacists' knowledge of COPD was good on general
topics, there were some gaps in their knowledge on the current care guideline and
status of the disease. Pharmacists should more systematically individually target
medication counseling according to patients' needs. In addition, lifestyle
treatments, including smoking cessation and physical exercise, should be part of
the medication counseling.
DOI: 10.2147/COPD.S159726
PMCID: PMC6037276
PMID: 30013334 [Indexed for MEDLINE]
Sheilini M(1), Hande HM(2), Prabhu MM(2), Pai MS(3), George A(4).
Author information:
(1)Department of Medical Surgical Nursing, Manipal College of Nursing Manipal,
MAHE, Manipal, Udupi District, Karnataka, India.
(2)Department of Medicine, Kasturba Hospital, MAHE, Manipal, Udupi District,
Karnataka, India.
(3)Department of Child Health Nursing, Manipal College of Nursing Manipal, MAHE,
Manipal, Udupi District, Karnataka, India.
(4)Department of Child Health Nursing, Manipal College of Nursing Manipal,
Manipal MAHE, Manipal, Udupi District, Karnataka, India.
DOI: 10.2147/PPA.S195446
PMCID: PMC6489579
PMID: 31114169
Seghatol-Eslami VC(1), Dark HE, Raper JL, Mugavero MJ, Turan JM, Turan B.
Author information:
(1)Departments of *Psychology;†Medicine, University of Alabama at Birmingham,
Birmingham, AL; and‡Department of Health Care Organization and Policy, School of
Public Health, University of Alabama at Birmingham, Birmingham, AL.
DOI: 10.1097/QAI.0000000000001177
PMCID: PMC5147512
PMID: 27926668 [Indexed for MEDLINE]
Annunziato RA(1), Bucuvalas JC(2), Yin W(3), Arnand R(3), Alonso EM(4),
Mazariegos GV(5), Venick RS(6), Stuber ML(7), Shneider BL(8), Shemesh E(9).
Author information:
(1)Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York,
NY; Department of Psychology, Fordham University, Bronx, NY. Electronic address:
annunziato@fordham.edu.
(2)Department of Pediatrics, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH.
(3)The Emmes Corporation, Rockville, MD.
(4)Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of
Chicago, Chicago, IL.
(5)Department of Surgery and Critical Care, Hillman Center for Pediatric
Transplantation Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
(6)Department of Pediatrics, Mattel Children's Hospital at UCLA, Los Angeles, CA.
(7)Department of Psychiatry, David Geffen School of Medicine at UCLA, Los
Angeles, CA.
(8)Texas Children's Hospital, Houston, TX.
(9)Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York,
NY.
Comment in
J Pediatr. 2018 Apr;195:307-308.
J Pediatr. 2018 Apr;195:307.
DOI: 10.1016/j.jpeds.2017.09.069
PMCID: PMC5889102
PMID: 29162346 [Indexed for MEDLINE]
Sayner R(1), Carpenter DM(2), Blalock SJ(2), Robin AL(3), Muir KW(4), Hartnett
ME(5), Giangiacomo AL(6), Tudor G(7), Sleath B(8).
Author information:
(1)Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of
Pharmacy, Chapel Hill, North Carolina. Electronic address: sayner@unc.edu.
(2)Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of
Pharmacy, Chapel Hill, North Carolina.
(3)Department of Ophthalmology and Visual Sciences, University of Maryland,
Baltimore, Maryland; Department of Ophthalmology and Department of International
Health, Johns Hopkins University, Baltimore, Maryland.
(4)Department of Ophthalmology, School of Medicine, Duke University, Durham,
North Carolina; Durham VA Medical Center, Health Services Research and
Development, Durham, North Carolina.
(5)Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center,
University of Utah, Salt Lake City, Utah.
(6)Ophthalmology Department, Emory University School of Medicine, Atlanta,
Georgia.
(7)Department of Science and Mathematics, Husson University, Bangor, Maine.
(8)Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of
Pharmacy, Chapel Hill, North Carolina; Cecil G. Sheps Center for Health Services
Research, University of North Carolina at Chapel Hill, Chapel Hill, North
Carolina.
PURPOSE: Glaucoma medications can improve clinical outcomes when patients adhere
to their medication regimen. Providers often ask patients with glaucoma to
self-report their adherence, but the accuracy of self-reporting has received
little scientific attention. The purpose of this article was to compare a
self-reported medication adherence measure with adherence data collected from
Medication Event Monitoring Systems (MEMS) electronic monitors. An additional
goal was to identify which patient characteristics were associated with
overreporting adherence on the self-reported measure.
METHODS: English-speaking adult patients with glaucoma were recruited from 6
ophthalmology practices for this observational cohort study. Patients were
interviewed after their initial visit and were given MEMS contains, which
recorded adherence over a 60-day period. MEMS percent adherence measured the
percentage of the prescribed number of doses taken. MEMS-measured timing
adherence assessed the percent doses taken on time. Patients self-reported
adherence to their glaucoma medications on a visual analog scale (VAS) ~60 days
after the baseline visit. Bivariate analyses and logistic regressions were used
to analyze the data. Self-reported medication adherence on the VAS was plotted
against MEMS adherence to illustrate the discrepancy between self-reported and
electronically monitored adherence.
FINDINGS: The analyses included 240 patients who returned their MEMS containers
and self-reported medication adherence at the 60-day follow-up visit. Compared
with MEMS-measured percent adherence, 31% of patients (n = 75) overestimated
their adherence on the VAS. Compared with MEMS-measured timing adherence, 74% (n
= 177) of patients overestimated their adherence. For the MEMS-measured percent
adherence, logistic regression revealed that patients who were newly prescribed
glaucoma medications were significantly more likely to overreport adherence on
the VAS (odds ratio, 3.07 [95% CI, 1.22-7.75]). For the MEMS-measured timing
adherence, being male (χ(2) test, 6.78; P = 0.009) and being prescribed glaucoma
medications dosed multiple times daily (χ(2) test, 4.02; P = 0.045) were
significantly associated with patients overreporting adherence. However, only
male sex remained a significant predictor of overreporting adherence in the
logistic regression (odds ratio, 4.05 [95% CI, 1.73-9.47]).
IMPLICATIONS: Many patients with glaucoma, especially those newly diagnosed,
overestimated their medication adherence. Because patients were likely to
overreport the percent doses taken and timing adherence, providers may want to
ask patients additional questions about when they take their glaucoma medications
to potentially detect issues with taking these medications on time.
DOI: 10.1016/j.clinthera.2015.06.008
PMCID: PMC4568126
PMID: 26164785 [Indexed for MEDLINE]
Langdon KJ(1), Fox AB(2), King LA(3), King DW(4), Eisen S(5), Vogt D(6).
Author information:
(1)National Center for PTSD, Women's Health Sciences Division, VA Boston
Healthcare System, United States; Department of Psychiatry, Boston University
School of Medicine, United States. Electronic address: kirstenjlangdon@gmail.com.
(2)National Center for PTSD, Women's Health Sciences Division, VA Boston
Healthcare System, United States.
(3)National Center for PTSD, Women's Health Sciences Division, VA Boston
Healthcare System, United States; Department of Psychiatry, Boston University
School of Medicine, United States; Department of Psychology, Boston University
School of Medicine, United States.
(4)Department of Psychiatry, Boston University School of Medicine, United States;
Department of Psychology, Boston University School of Medicine, United States;
National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare
System, United States.
(5)Center for Healthcare Organization and Implementation Research, Edith Nourse
Rogers Memorial Veterans Hospital, United States; Department of Health Policy and
Management, Boston University School of Public Health, United States.
(6)National Center for PTSD, Women's Health Sciences Division, VA Boston
Healthcare System, United States; Department of Psychiatry, Boston University
School of Medicine, United States.
DOI: 10.1016/j.jad.2016.02.048
PMCID: PMC4808402
PMID: 26938966 [Indexed for MEDLINE]
760. Patient. 2016 Apr;9(2):171-80. doi: 10.1007/s40271-015-0136-x.
Poulos C(1), Kinter E(2), Yang JC(3), Bridges JF(4), Posner J(5), Reder AT(6).
Author information:
(1)RTI Health Solutions, 200 Park Offices Drive, Research Triangle Park, PO Box
12194, Durham, NC, 27709, USA. cpoulos@rti.org.
(2)Biogen, Cambridge, MA, USA.
(3)Pacific Economic Research, LLC, Bellevue, WA, USA.
(4)Johns Hopkins University, Baltimore, MD, USA.
(5)RTI Health Solutions, 200 Park Offices Drive, Research Triangle Park, PO Box
12194, Durham, NC, 27709, USA.
(6)University of Chicago Medicine, Chicago, IL, USA.
DOI: 10.1007/s40271-015-0136-x
PMCID: PMC4796329
PMID: 26259849 [Indexed for MEDLINE]
Author information:
(1)Royal District Nursing Service, 31 Alma Rd, St Kilda, Victoria 3182,
Australia. dgoeman@rdns.com.au.
PMCID: PMC5396255
PMID: 26265487 [Indexed for MEDLINE]
Author information:
(1)University of Utah.
(2)College of Nursing, University of Utah.
(3)Seattle Children's Hospital.
(4)Mary Bridge Children's Hospital and Health Center/MultiCare Health System.
DOI: 10.1188/18.ONF.69-76
PMCID: PMC5927589
PMID: 29251285 [Indexed for MEDLINE]
763. Ann Med Health Sci Res. 2014 Nov;4(6):922-7. doi: 10.4103/2141-9248.144914.
Kamran A(1), Sadeghieh Ahari S(2), Biria M(2), Malepour A(2), Heydari H(3).
Author information:
(1)Department of Public Health, School of Health, Ardabil University of Medical
Sciences, Ardabil, Iran.
(2)Department of Community Medicine, School of Medicine, Ardabil University of
Medical Sciences, Ardabil, Iran.
(3)Department of Community Health, School of Nursing and Midwifery, Tehran
University of Medical Sciences, Tehran, Iran.
764. BMJ Open Diabetes Res Care. 2016 May 9;4(1):e000201. doi:
10.1136/bmjdrc-2016-000201. eCollection 2016.
Integrative health coaching: a behavior skills approach that improves HbA1c and
pharmacy claims-derived medication adherence.
Author information:
(1)Department of Physical Medicine and Rehabilitation, Osher Center for
Integrative Medicine, Vanderbilt Schools of Medicine & Nursing, Nashville,
Tennessee, USA; Duke Integrative Medicine, Duke University School of Medicine,
Durham, North Carolina, USA.
(2)Duke Integrative Medicine , Duke University School of Medicine , Durham, North
Carolina , USA.
DOI: 10.1136/bmjdrc-2016-000201
PMCID: PMC4873948
PMID: 27239318
Author information:
(1)Department of Psychiatry and Psychotherapy, University Clinic,
Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, 91054,
Erlangen, Germany. Christian.Mueller@uk-erlangen.de.
(2)Department of Psychiatry and Psychotherapy, University Clinic,
Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, 91054,
Erlangen, Germany.
(3)Bruker Daltonik GmbH, Bremen, Germany.
(4)Institute of Human Genetics, Friedrich-Alexander-Universität
Erlangen-Nürnberg, Erlangen, Germany.
(5)Chair of Toxicology, Faculty of Pharmacy, Jagiellonian University Medical
College, Krakow, Poland.
(6)Institute of Pharmacology, Polish Academy of Sciences, Laboratory of Drug
Addiction Pharmacology, 12 Smetna, Krakow, 31-343, Poland.
(7)Institute of Biochemistry, Friedrich-Alexander-University of
Erlangen-Nuremberg, 91054, Erlangen, Germany.
(8)Department of Molecular Biology, University of Duisburg-Essen, Essen, Germany.
(9)Department of Surgery, College of Medicine, University of Cincinnati, 231
Albert Sabin Way, Cincinnati, OH, 45267-0558, USA.
(10)Division of Child Health, Obstetrics and Gynaecology, School of Medicine,
University of Nottingham, Nottingham, NG7 2UH, UK.
(11)Department of Nephrology and Hypertension, Friedrich-Alexander-University
Erlangen-Nuremberg, Schwabachanlage 12, 91054, Erlangen, Germany.
Alcohol is a widely consumed drug that can lead to addiction and severe brain
damage. However, alcohol is also used as self-medication for psychiatric
problems, such as depression, frequently resulting in depression-alcoholism
comorbidity. Here, we identify the first molecular mechanism for alcohol use with
the goal to self-medicate and ameliorate the behavioral symptoms of a genetically
induced innate depression. An induced over-expression of acid sphingomyelinase
(ASM), as was observed in depressed patients, enhanced the consumption of alcohol
in a mouse model of depression. ASM hyperactivity facilitates the establishment
of the conditioned behavioral effects of alcohol, and thus drug memories.
Opposite effects on drinking and alcohol reward learning were observed in animals
with reduced ASM function. Importantly, free-choice alcohol drinking-but not
forced alcohol exposure-reduces depression-like behavior selectively in depressed
animals through the normalization of brain ASM activity. No such effects were
observed in normal mice. ASM hyperactivity caused sphingolipid and subsequent
monoamine transmitter hypo-activity in the brain. Free-choice alcohol drinking
restores nucleus accumbens sphingolipid- and monoamine homeostasis selectively in
depressed mice. A gene expression analysis suggested strong control of ASM on the
expression of genes related to the regulation of pH, ion transmembrane transport,
behavioral fear response, neuroprotection and neuropeptide signaling pathways.
These findings suggest that the paradoxical antidepressant effects of alcohol in
depressed organisms are mediated by ASM and its control of sphingolipid
homeostasis. Both emerge as a new treatment target specifically for
depression-induced alcoholism.
DOI: 10.1007/s00401-016-1658-6
PMCID: PMC5325869
PMID: 28000031 [Indexed for MEDLINE]
766. Int J Clin Pharm. 2019 Feb;41(1):113-121. doi: 10.1007/s11096-018-0756-z. Epub
2018 Nov 26.
Author information:
(1)Aston Pharmacy School, Aston University, Birmingham, UK. jeff.aston@nhs.net.
(2)Pharmacy Department, Birmingham Women's and Children's NHS Foundation Trust,
Birmingham, UK. jeff.aston@nhs.net.
(3)Aston Pharmacy School, Aston University, Birmingham, UK.
Background Taking regular medication has been shown to have an impact on the
daily lives of patients and their families. Objective To explore the
medication-related experiences of patients and their families when a child or
young person is prescribed regular medication. Setting A specialist U.K.
paediatric hospital. Method Semi-structured face-to-face interviews of 24
parents/carers, children or young people, who had been taking two or more
medications for 6 weeks or longer. The themes explored included the medication
regimen, formulation, supplies, social aspects and adverse effects. The data was
analysed using NVIVO version 11. Main outcome measure The experiences of
patients, and their parents/carers, when a child/young person takes regular
medication. Results Participants described a range of experiences associated with
taking regular medication. Medication-related challenges were experienced around
the timing of administration which was managed over 24 h rather than waking
hours. Updating medication doses for administration at school was often delayed.
Unintended nonadherence was cited as the biggest challenge with a range of
strategies employed to manage this. The internet was commonly used as a source of
additional information accessed for reassurance and adverse effects but there
were varying experiences of using patient forums/help groups. Other challenges
included the adequacy of information, travelling with medication, formulation
issues, arranging supplies and adverse effects. Conclusion Patients and parents
experience many challenges with children's medication. Individualised treatment
options should be considered. Further research is required to determine how these
experiences may be managed including the role of paediatric medication review.
DOI: 10.1007/s11096-018-0756-z
PMCID: PMC6394506
PMID: 30478490 [Indexed for MEDLINE]
Author information:
(1)Emory University School of Medicine, 1364 Clifton Rd NE, Atlanta, GA 30322.
E-mail: arun.mohan@emory.edu.
Asthma and Asthma Medication Are Common among Recreational Athletes Participating
in Endurance Sport Competitions.
Näsman A(1), Irewall T(1), Hållmarker U(2), Lindberg A(3), Stenfors N(1).
Author information:
(1)Department of Public Health and Clinical Medicine, Unit of Medicine-Östersund,
Umeå University, 90187 Umeå, Sweden.
(2)Department of Internal Medicine, Mora Hospital, 79285 Mora, Sweden.
(3)Department of Public Health and Clinical Medicine, Unit of Medicine-Sunderbyn,
Umeå University, 90187 Umeå, Sweden.
Background: Asthma prevalence is high among elite endurance athletes, but little
is known about its prevalence among competitive recreational athletes. The aim of
this study was to determine the prevalence of self-reported asthma and asthma
medication use among competitive recreational endurance athletes and their
association with training.
Methods: A web survey on asthma and medication was conducted among 38,603 adult
participants of three Swedish endurance competitions (cross-country running,
cross-country skiing, and swimming).
Results: The overall response rate was 29%. The prevalence of self-reported
asthma (physician-diagnosed asthma and use of asthma medication in the last 12
months) was 12%. Among those reporting asthma, 23% used inhaled corticosteroids
and long-acting beta-agonists daily. We found no association between training
volume and daily use of asthma medication, except a trend in relation to
short-acting beta-agonists. Independent predictors of self-reported asthma were
female sex, allergic rhinitis, previous eczema, family history of asthma,
cycling, and training for >5 h 50 min/week.
Conclusions: The prevalence of self-reported asthma among Swedish competitive
recreational endurance athletes appears to be higher than that in the general
Swedish population. A large proportion of recreational athletes were reported
with asthma use medications, indicating an association between high physical
activity and self-reported asthma among competitive recreational athletes.
DOI: 10.1155/2018/3238546
PMCID: PMC6032657
PMID: 30034562 [Indexed for MEDLINE]
Krauskopf K(1), Federman AD, Kale MS, Sigel KM, Martynenko M, O'Conor R, Wolf MS,
Leventhal H, Wisnivesky JP.
Author information:
(1)1Division of General Internal Medicine, Icahn School of Medicine at Mount
Sinai , New York, NY , USA.
Almost half of patients with COPD do not adhere to their medications. Illness and
medication beliefs are important determinants of adherence in other chronic
diseases. Using the framework of the Common Sense Model of Self-Regulation (CSM),
we determined associations between potentially modifiable beliefs and adherence
to COPD medications in a cohort of English- and Spanish-speaking adults with COPD
from New York and Chicago. Medication adherence was assessed using the Medication
Adherence Report Scale. Illness and medication beliefs along CSM domains were
evaluated using the Brief Illness Perception Questionnaire (B-IPQ) and the
Beliefs about Medications Questionnaire (BMQ). Unadjusted analysis (with Cohen's
d effect sizes) and multiple logistic regression were used to assess the
relationship between illness and medication beliefs with adherence. The study
included 188 participants (47% Black, 13% Hispanics); 109 (58%) were
non-adherent. Non-adherent participants were younger (p < 0.001), more likely to
be Black or Hispanic (p = 0.001), to have reported low income (p = 0.02), and had
fewer years of formal education (p = 0.002). In unadjusted comparisons,
non-adherent participants reported being more concerned about their COPD (p =
0.011; Cohen's d = 0.43), more emotionally affected by the disease (p = 0.001;
Cohen's d = 0.54), and had greater concerns about COPD medications (p < 0.001,
Cohen's d = 0.81). In adjusted analyses, concerns about COPD medications
independently predicted non-adherence (odds ratio: 0.52, 95% confidence interval:
0.36-0.75). In this cohort of urban minority adults, concerns about medications
were associated with non-adherence. Future work should explore interventions to
influence patient adherence by addressing concerns about the safety profile and
long-term effects of COPD medications.
DOI: 10.3109/15412555.2014.922067
PMCID: PMC4305045
PMID: 24960306 [Indexed for MEDLINE]
Author information:
(1)Department of Health Economics, University of Szeged, Szeged, Hungary,
buzas.norbert@med.u-szeged.hu.
(2)Department of Psychology, University of Szeged, Szeged, Hungary.
(3)1st Department of Internal Medicine, University of Szeged, Szeged, Hungary.
DOI: 10.2147/PPA.S187080
PMCID: PMC6422420
PMID: 30936685
Flickinger TE(1), Saha S(2), Roter D(3), Korthuis PT(4), Sharp V(5), Cohn J(6),
Eggly S(6), Moore RD(3), Beach MC(3).
Author information:
(1)University of Virginia School of Medicine, Charlottesville, VA, USA.
Electronic address: TES3J@hscmail.mcc.virginia.edu.
(2)Portland VA Medical Center, Portland, OR, USA; Oregon Health and Science
University, Portland, OR, USA.
(3)Johns Hopkins University, Baltimore, MD, USA.
(4)Oregon Health and Science University, Portland, OR, USA.
(5)St Luke's Roosevelt, New York, NY, USA.
(6)Wayne State University, Detroit, MI, USA.
Comment in
Patient Educ Couns. 2016 Feb;99(2):171-2.
DOI: 10.1016/j.pec.2015.09.001
PMCID: PMC5610904
PMID: 26395313 [Indexed for MEDLINE]
Savitz ST(1), Stearns SC, Zhou L, Thudium E, Alburikan KA, Tran R, Rodgers JE.
Author information:
(1)*Department of Health Policy & Management †Cecil G. Sheps Center for Health
Services Research, The University of North Carolina at Chapel Hill ‡UNC Eshelman
School of Pharmacy, Chapel Hill, NC §College of Pharmacy, King Saud University,
Riyadh, Kingdom of Saudi Arabia.
OBJECTIVE: Medicare Part D claims indicate medication purchased, but people who
are not fully adherent may extend prescription use beyond the interval
prescribed. This study assessed concordance between Part D claims and medication
possession at a study visit in relation to self-reported medication adherence.
MATERIALS AND METHODS: We matched Part D claims for 6 common medications to
medications brought to a study visit in 2011-2013 for the Atherosclerosis Risk in
Communities study. The combined data consisted of 3027 medication events (claims,
medications possessed, or both) for 2099 Atherosclerosis Risk in Communities
study participants. Multinomial logistic regression estimated the association of
concordance (visit only, Part D only, or both) with self-reported medication
adherence while controlling for sociodemographic characteristics, veteran status,
and availability under Generic Drug Discount Programs.
RESULTS: Relative to participants with high adherence, medication events for
participants with low adherence were approximately 25 percentage points less
likely to match and more likely to be visit only (P<0.001). The results were
similar but smaller in magnitude (approximately 2-3 percentage points) for
participants with medium adherence. Compared with females, medication events for
male veterans were approximately 11 percentage points less likely to match and
more likely to be visit only. Events for medications available through Generic
Drug Discount Programs were 3 percentage points more likely to be visit only.
CONCLUSIONS: Part D claims were substantially less likely to be concordant with
medications possessed at study visit for participants with low self-reported
adherence. This result supports the construction of adherence proxies such as
proportion days covered using Part D claims.
DOI: 10.1097/MLR.0000000000000701
PMCID: PMC5391286
PMID: 28221276 [Indexed for MEDLINE]
Author information:
(1)Institute of Health and Care Sciences, Sahlgrenska Academy, University of
Gothenburg , Sweden.
DOI: 10.3109/08037051.2014.901009
PMCID: PMC4196575
PMID: 24786778 [Indexed for MEDLINE]
774. BMJ Open. 2015 Nov 9;5(11):e009490. doi: 10.1136/bmjopen-2015-009490.
Fujita M(1), Sato Y(2), Nagashima K(2), Takahashi S(3), Hata A(1).
Author information:
(1)Department of Public Health, Chiba University, Chiba, Japan.
(2)Department of Global Clinical Research, Chiba University, Chiba, Japan Chiba
University Hospital, Clinical Research Center, Chiba, Japan.
(3)Chiba University Hospital, Clinical Research Center, Chiba, Japan.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://www.bmj.com/company/products-services/rights-and-licensing/
DOI: 10.1136/bmjopen-2015-009490
PMCID: PMC4654279
PMID: 26553839 [Indexed for MEDLINE]
DOI: 10.1016/j.atherosclerosis.2015.08.026
PMCID: PMC4575898
PMID: 26342332 [Indexed for MEDLINE]
Feehan M(1)(2), Morrison MA(2), Tak C(1), Morisky DE(3), DeAngelis MM(2), Munger
MA(1).
Author information:
(1)The Department of Pharmacotherapy, College of Pharmacy, University of Utah,
Salt Lake City, Utah, USA.
(2)The Moran Eye Center, Department of Ophthalmology and Visual Sciences, Moran
Eye Centre, University of Utah School of Medicine, Salt Lake City, Utah, USA.
(3)Department of Community Health Sciences, UCLA Fielding School of Public
Health, Los Angeles, California, USA.
Erratum in
BMJ Open. 2017 Sep 1;7(8):e014435corr1.
OBJECTIVES: The study objective was to determine the level and correlates of
self-reported medication low adherence in the US general population.
SETTING: A 30 min cross-sectional online survey was conducted with a national
sample of adults.
PARTICIPANTS: 9202 adults (aged 18+) who had filled at least three or more
prescriptions at a community pharmacy in the past 12 months.
PRIMARY AND SECONDARY OUTCOME MEASURES: Self-reported medication adherence was
measured with the 8-item Morisky Medication Adherence Scale.
RESULTS: Low adherence was reported by 42.0%, 29.4% had medium adherence and
28.6% had high adherence. Low adherence was significantly associated with: lower
age, being of Hispanic origin or African-American, having difficulty with
healthcare, medication or transportation costs, needing the support of others to
access primary care, health limiting activity, using multiple providers,
infrequent visits to primary care providers and visiting an emergency department
>3 times in last 12 months.
CONCLUSIONS: A very high level of low medication adherence is seen in the general
population, particularly for ethnic minorities, those who use multiple healthcare
providers and those who experience barriers to access for regular primary care.
As clinical, patient education and counselling, and healthcare policy initiatives
are directed to tracking the problem of low medication adherence, these should be
priority populations for research and interventions.
© Article author(s) (or their employer(s) unless otherwise stated in the text of
the article) 2017. All rights reserved. No commercial use is permitted unless
otherwise expressly granted.
DOI: 10.1136/bmjopen-2016-014435
PMCID: PMC5623408
PMID: 28645958 [Indexed for MEDLINE]
Dokbua S(1), Dilokthornsakul P(2), Chaiyakunapruk N(3), Saini B(4), Krass I(4),
Dhippayom T(1).
Author information:
(1)1 Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok,
Thailand.
(2)2 Center of Pharmaceutical Outcomes Research, Department of Pharmacy Practice,
Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.
(3)3 Center of Pharmaceutical Outcomes Research, Department of Pharmacy Practice,
Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand;
School of Pharmacy, Monash University Malaysia, Selangor, Malaysia; School of
Pharmacy, University of Wisconsin, Madison; and Asian Centre for Evidence
Synthesis in Population, Implementation and Clinical Outcomes, Health and
Well-being Cluster, Global Asia in the 21st Century Platform, Monash University
Malaysia, Selangor.
(4)4 Faculty of Pharmacy, the University of Sydney, Australia.
BACKGROUND: Current evidence of the effects of pharmacy services on asthma
outcomes are not conclusive, since most pharmacy services comprise a variety of
interventions.
OBJECTIVE: To assess the effect of a service containing self-management support
delivered by community pharmacists to patients with asthma.
METHODS: A systematic search was performed in the following databases from
inception to January 2017: PubMed, Embase, Cochrane Library's Central Register of
Controlled Trials, CINAHL (Cumulative Index to Nursing and Allied Health
Literature) Plus, International Pharmaceutical Abstracts, and PsycInfo. Original
studies were selected if they met the following criteria: (a) provided by
community pharmacists; (b) the intervention service included the essential
components of asthma self-management; (c) included a usual care group; and (d)
measured control/severity of asthma symptoms, health-related quality of life
(HRQOL), or medication adherence.
RESULTS: Of the 639 articles screened, 12 studies involving 2,121 asthma patients
were included. Six studies were randomized trials, and the other 6 were
nonrandomized trials. Patients with asthma who received a self-management support
service by community pharmacists had better symptom control/lower severity
compared with those receiving usual care (standardized mean difference [SMD] =
0.46; 95% CI = 0.09-0.82) with high heterogeneity (I2=82.6%; P = 0.000). The
overall improvement in HRQOL and medication adherence among patients in the
asthma self-management support group was greater than for those in the usual care
group with SMD of 0.23 (95% CI = 0.12-0.34) and 0.44 (95% CI = 0.27-0.61),
respectively. Evidence of heterogeneity was not observed in these 2 outcomes.
CONCLUSIONS: Self-management support service provided by community pharmacists
can help improve symptom control, quality of life, and medication adherence in
patients with asthma.
DISCLOSURES: This study received financial support from Naresuan University's
Faculty of Pharmaceutical Sciences Research Fund. Two authors, Saini and Krass,
have studies that were included in this review. However, they were not involved
in the processes that could bias outcomes of the present study, that is, quality
assessment and meta-analysis. The remaining authors have declared no conflicts of
interest.
DOI: 10.18553/jmcp.2018.24.11.1184
PMID: 30362920 [Indexed for MEDLINE]
Author information:
(1)Michigan State University.
DOI: 10.1188/18.ONF.508-526
PMID: 29947359 [Indexed for MEDLINE]
Tricarico C(1), Peters R(1), Som A(1)(2), Javaherian K(1), Ross W(1).
Author information:
(1)Washington University in St. Louis School of Medicine, St. Louis, MO, United
States.
(2)Epharmix Research Center, St. Louis, MO, United States.
DOI: 10.2196/resprot.7223
PMCID: PMC5447823
PMID: 28506954
Krousel-Wood M(1), Holt E, Joyce C, Ruiz R, Dornelles A, Webber LS, Morisky DE,
Frohlich ED, Re RN, He J, Whelton PK, Muntner P.
Author information:
(1)aDepartment of Medicine, Tulane University School of Medicine bCenter for
Health Research, Ochsner Clinic Foundation cDepartment of Epidemiology, Tulane
University School of Public Health and Tropical Medicine dDepartment of
Biostatistics and Bioinformatics, Tulane University School of Public Health and
Tropical Medicine eOffice of Medical Education, Tulane University School of
Medicine, New Orleans, Louisiana (work done while at the Center for Health
Research, Ochsner Clinic Foundation) fDepartment of Community Health Sciences,
UCLA Fielding School of Public Health, Los Angeles, California gDepartment of
Cardiology-Hypertension Section, Ochsner Clinic Foundation, New Orleans,
Louisiana hDepartment of Epidemiology, University of Alabama at Birmingham,
Birmingham, Alabama, USA.
Bremer L(1), Goletzke J(2), Wiessner C(3), Pagenkemper M(4), Gehbauer C(5),
Becher H(6), Tolosa E(7), Hecher K(8), Arck PC(9), Diemert A(10), Tiegs G(11).
Author information:
(1)Institute of Experimental Immunology and Hepatology, University Medical Center
Hamburg Eppendorf, Martinistrasse 52, Hamburg 20246, Germany. Electronic address:
La.Bremer@uke.de.
(2)Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg
Eppendorf, Martinistrasse 52, Hamburg 20246, Germany. Electronic address:
J.Goletzke@uke.de.
(3)Institute of Medical Biometry and Epidemiology, University Medical Center
Hamburg Eppendorf, Martinistrasse 52, Hamburg 20246, Germany. Electronic address:
C.Wiessner@uke.de.
(4)Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg
Eppendorf, Martinistrasse 52, Hamburg 20246, Germany. Electronic address:
M.Pagenkemper@uke.de.
(5)Department of Immunology, University Medical Center Hamburg Eppendorf,
Martinistrasse 52, Hamburg 20246, Germany. Electronic address: C.Gehbauer@uke.de.
(6)Institute of Medical Biometry and Epidemiology, University Medical Center
Hamburg Eppendorf, Martinistrasse 52, Hamburg 20246, Germany. Electronic address:
H.Becher@uke.de.
(7)Department of Immunology, University Medical Center Hamburg Eppendorf,
Martinistrasse 52, Hamburg 20246, Germany. Electronic address: E.Tolosa@uke.de.
(8)Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg
Eppendorf, Martinistrasse 52, Hamburg 20246, Germany. Electronic address:
K.Hecher@uke.de.
(9)Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg
Eppendorf, Martinistrasse 52, Hamburg 20246, Germany. Electronic address:
P.Arck@uke.de.
(10)Department of Obstetrics and Fetal Medicine, University Medical Center
Hamburg Eppendorf, Martinistrasse 52, Hamburg 20246, Germany. Electronic address:
A.Diemert@uke.de.
(11)Institute of Experimental Immunology and Hepatology, University Medical
Center Hamburg Eppendorf, Martinistrasse 52, Hamburg 20246, Germany. Electronic
address: G.Tiegs@uke.de.
Copyright © 2017 The Author(s). Published by Elsevier B.V. All rights reserved.
DOI: 10.1016/j.ebiom.2017.10.023
PMCID: PMC5832562
PMID: 29129700 [Indexed for MEDLINE]
782. Drug Discov Ther. 2019 Jul 22;13(3):150-156. doi: 10.5582/ddt.2019.01035. Epub
2019 Jun 28.
Generic selection criteria for safety and patient benefit [VIII]: Comparing the
physicochemical and pharmaceutical properties of brand-name and generic
diclofenac sodium tapes.
Nozawa M(1), Goto M(1), Wada Y(2), Yotsukura K(3), Gannichida A(3), Ishii F(2),
Shimokawa KI(3).
Author information:
(1)Triad Japan Co. Ltd.
(2)Department of Self-medication and Health Care Sciences, Meiji Pharmaceutical
University.
(3)Department of Pharmaceutical Sciences, Meiji Pharmaceutical University.
Author information:
(1)Department of Pharmacology and Therapeutics, j.lemay@hsc.edu.kw.
(2)Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University,
Safat, Kuwait.
DOI: 10.2147/PPA.S169236
PMCID: PMC6130270
PMID: 30233149
Hsu KL(1), Fink JC(2), Ginsberg JS(1), Yoffe M(1), Zhan M(3), Fink W(1), Woods
CM(4), Diamantidis CJ(5).
Author information:
(1)Department of Medicine, University of Maryland School of Medicine, Baltimore,
MD.
(2)Department of Medicine, University of Maryland School of Medicine, Baltimore,
MD; Department of Epidemiology and Public Health, University of Maryland School
of Medicine, Baltimore, MD; Department of Medicine, Veterans Affairs Maryland
Health Care System, Baltimore, MD.
(3)Department of Epidemiology and Public Health, University of Maryland School of
Medicine, Baltimore, MD.
(4)University of Maryland School of Pharmacy, Baltimore, MD.
(5)Department of Medicine, Duke University School of Medicine, Durham, NC;
Department of Medicine, Durham Veterans Affairs Medical Center, Durham, NC.
Electronic address: clarissa.diamantidis@duke.edu.
Copyright © 2015 National Kidney Foundation, Inc. Published by Elsevier Inc. All
rights reserved.
DOI: 10.1053/j.ajkd.2015.03.026
PMCID: PMC4586079
PMID: 25979348 [Indexed for MEDLINE]
Author information:
(1)Department of Pulmonary Medicine, Hvidovre Hospital, Hvidovre, Denmark.
DOI: 10.1159/000447244
PMID: 27348313 [Indexed for MEDLINE]
786. BMC Health Serv Res. 2017 Jul 6;17(1):464. doi: 10.1186/s12913-017-2418-6.
Author information:
(1)Dutch Health Care Inspectorate (IGZ), Department Nursing and Long-Term Care,
Utrecht, the Netherlands. ja.vermeulen@igz.nl.
(2)Dutch Health Care Inspectorate (IGZ), PO Box 2518, 6401, DA, Heerlen, the
Netherlands. ja.vermeulen@igz.nl.
(3)Dutch Health Care Inspectorate (IGZ), Department Risk Identification and
Development, Utrecht, the Netherlands.
(4)Dutch Health Care Inspectorate (IGZ), Department Nursing and Long-Term Care,
Utrecht, the Netherlands.
(5)Radboud University Medical Center, Radboud Institute for Health Sciences, IQ
Healthcare, Nijmegen, the Netherlands.
BACKGROUND: In 2009, the Dutch Health Care Inspectorate (IGZ) observed several
serious risks to safety involving medication within elderly care facilities.
However, by 2011, high risks had been reduced in almost all the organisations we
visited. And yet the IGZ analysed too the alarming increase in the number of
incidents arising in the self-reported national indicator of medication safety
between 2009 and 2010. The aim of this study was to understand the factors that
can explain this contradiction between the increase in self-reported medication
incidents and the observation of the IGZ in reducing the risks to medication
safety through supervision.
METHODS: We interviewed health care professionals of ten care facilities, visited
by the IGZ, who were involved in, or responsible for, the improvement of
medication safety in their institutions. As outcome measures we used the rate of
medication safety risk per facility; the perceptions of the participant with
regard to the reports of medication incidents; the level of medication safety of
the facility; the measures used to improve medication safety; and the supervision
of medication safety. This was a mixed methods study, qualitative in that we used
semi-structured interviews, and quantitative, by calculating risks for the
different organisations we visited. The findings from both study methods resulted
in a comprehensive view and an in-depth understanding of this contradiction.
RESULTS: The contradiction between the increase in self-reported medication
incidents and the observation of reduced risks was explained by three themes:
activities designed to improve medication safety, the reporting of medication
incidents, and, lastly, the impact of supervision. The focus of the IGZ on issues
of medication safety stimulated most elderly care facilities to reduce medication
risks. Also, a change in the culture of reporting incidents caused an increase in
the number of reported incidents.
CONCLUSIONS: Supervision contributed to an improvement in actions geared towards
reducing the risks associated with the safety of medication. It also increased a
willingness to report such incidents. The more incidents reported are therefore
not necessarily a sign of an increase in the risks, but can also be considered as
a sign of a safer culture.
DOI: 10.1186/s12913-017-2418-6
PMCID: PMC5501537
PMID: 28683748 [Indexed for MEDLINE]
Dasappa H(1), Prasad S(2), Sirisha M(1), Ratna Prasanna SVN(1), Naik S(3).
Author information:
(1)Department of Family Medicine, St. Philomena Hospital, Bengaluru, Karnataka,
India.
(2)Medical Superintendent, St. Philomenas Hospital, Bengaluru, Karnataka, India.
(3)Lecturer, St. Philomena's Nursing College, Bengaluru, Karnataka, India.
DOI: 10.4103/2249-4863.220037
PMCID: PMC5749060
PMID: 29302521
Ociskova M(1), Prasko J(1), Vrbova K(1), Kasalova P(1), Holubova M(1), Grambal
A(1), Machu K(2).
Author information:
(1)Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky
University, University Hospital, Olomouc.
(2)Department of Psychology, Faculty of Arts, University of Ostrava, Ostrava, The
Czech Republic.
Goal: The goal of this study was to explore the impact of self-stigma on the
treatment outcomes in patients with anxiety disorders and to find possible
mediators of this relationship.
Method: Two hundred and nine patients with anxiety disorders, who were
hospitalized in a psychotherapeutic department, attended the study. The average
age was 39.2±12.4 years; two-thirds were women. Most of the patients used a
long-term medication. The participants underwent either cognitive behavioral
therapy (CBT) or short psychodynamic therapy. The selection to the psychotherapy
was not randomized. All individuals completed several scales - Beck Depression
Inventory, the second edition (BDI-II), Beck Anxiety Inventory (BAI),
Dissociative Experience Scale (DES), Sheehan Disability Scale (SDS), subjective
Clinical Global Impression (subjCGI), and The Internalized Stigma of Mental
Illness Scale (ISMI). A senior psychiatrist filled out the objective CGI
(objCGI).
Results: The patients significantly improved in the severity of anxiety (BAI),
depression (BDI-II), and overall severity of the mental disorder (objCGI). The
self-stigma predicted a lower change of the objCGI, but not a change of the
anxiety and depressive symptoms severity. Anxiety, depressive symptoms,
dissociation, and disability were assessed as possible mediators of the
relationship between the self-stigma and the treatment change. None of them were
significant.
Conclusion: Self-stigma lowers the effectiveness of the combined treatment of
anxiety disorders. Future research should explore other possible mediators
influencing this relationship.
DOI: 10.2147/NDT.S152208
PMCID: PMC5790087
PMID: 29416340
The Use and Effects of Electronic Health Tools for Patient Self-Monitoring and
Reporting of Outcomes Following Medication Use: Systematic Review.
Lancaster K(#)(1), Abuzour A(2), Khaira M(2)(3), Mathers A(2), Chan A(4), Bui
V(5), Lok A(6), Thabane L(4), Dolovich L(1)(2).
Author information:
(1)Department of Family Medicine, McMaster University, Hamilton, ON, Canada.
(2)Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.
(3)School of Pharmacy, University of Waterloo, Waterloo, ON, Canada.
(4)Department of Health Research Methods, Evidence, and Impact, McMaster
University, Hamilton, ON, Canada.
(5)Pharmacy Department, Sunnybrook Health Sciences, Toronto, ON, Canada.
(6)Michael G. DeGroote National Pain Centre, McMaster University, Hamilton, ON,
Canada.
(#)Contributed equally
©Karla Lancaster, Aseel Abuzour, Manmeet Khaira, Annalise Mathers, April Chan,
Vivian Bui, Annie Lok, Lehana Thabane, Lisa Dolovich. Originally published in the
Journal of Medical Internet Research (http://www.jmir.org), 18.12.2018.
DOI: 10.2196/jmir.9284
PMCID: PMC6315271
PMID: 30563822
Butler RK(1), Knapp DJ, Ulici V, Longobardi L, Loeser RF, Breese GR.
Author information:
(1)aBowles Center for Alcohol Studies, The University of North Carolina at Chapel
Hill, Chapel Hill, NC, USA bDepartment of Psychiatry, The University of North
Carolina at Chapel Hill, Chapel Hill, NC, USA cThurston Arthritis Research
Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
dDivision of Rheumatology, Allergy and Immunology, The University of North
Carolina at Chapel Hill, Chapel Hill, NC, USA, Department of Medicine eDepartment
of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill,
NC, USA fCurriculum in Neurobiology, The University of North Carolina at Chapel
Hill, Chapel Hill, NC, USA gThe UNC Neuroscience Center, The University of North
Carolina at Chapel Hill, Chapel Hill, NC, USA.
Chronic pain conditions are often comorbid with alcohol abuse. "Self-medication"
with alcohol introduces a host of problems associated with the abuse of alcohol
which over time has the potential of exacerbating the painful condition. Despite
the prevalence of chronic pain being associated with alcohol abuse, rodent models
which mimic the comorbid conditions are lacking. In this study, we model
osteoarthritis (OA) in C57BL/6J mice by surgically destabilizing the medial
meniscus (DMM). Sham-operated mice served as controls. Thirteen weeks after
surgery, DMM but not sham-operated mice exhibited pronounced incapacitance of the
surgically manipulated hind limb compared with the nonsurgically manipulated hind
limb. At this time, the mice were exposed to the 2-bottle ethanol choice,
beginning with 2.5% with a gradual increasing to 20%. Compared with sham
controls, DMM mice consumed more EtOH and preferred EtOH over water at the 20%
EtOH concentration. Histological analysis verified that the DMM mice exhibited
significant damage to the articular cartilage and osteophyte growth compared with
sham controls and these measures of the severity of OA correlated with the amount
of ethanol intake. Thus, the combination of the DMM model of OA with the enhanced
two-bottle ethanol choice is a potential preclinical approach in mice by which
the basis of the comorbid association of alcohol abuse and chronic pain
conditions can be explored.
DOI: 10.1097/j.pain.0000000000000780
PMCID: PMC5303149
PMID: 27918314 [Indexed for MEDLINE]
Johnson KB(1), Patterson BL(2), Ho YX(3), Chen Q(4), Nian H(5), Davison CL(3),
Slagle J(6), Mulvaney SA(7).
Author information:
(1)Department of Biomedical Informatics at Vanderbilt University School of
Medicine, Nashville, TN, USA Department of Pediatrics at Vanderbilt University
School of Medicine, Nashville, TN, USA kevin.johnson@vanderbilt.edu.
(2)Department of Pediatrics at Vanderbilt University School of Medicine,
Nashville, TN, USA.
(3)Department of Biomedical Informatics at Vanderbilt University School of
Medicine, Nashville, TN, USA.
(4)Department of Biomedical Informatics at Vanderbilt University School of
Medicine, Nashville, TN, USA Department of Biostatistics at Vanderbilt University
School of Medicine, Nashville, TN, USA.
(5)Department of Biostatistics at Vanderbilt University School of Medicine,
Nashville, TN, USA.
(6)Department of Anesthesiology at Vanderbilt University School of Medicine,
Nashville, TN, USA.
(7)Department of Biomedical Informatics at Vanderbilt University School of
Medicine, Nashville, TN, USA School of Nursing at Vanderbilt University School of
Medicine, Nashville, TN, USA.
OBJECTIVE: Personal health applications have the potential to help patients with
chronic disease by improving medication adherence, self-efficacy, and quality of
life. The goal of this study was to assess the impact of MyMediHealth (MMH) - a
website and a short messaging service (SMS)-based reminder system - on medication
adherence and perceived self-efficacy in adolescents with asthma.
METHODS: We conducted a block-randomized controlled study in academic pediatric
outpatient settings. There were 98 adolescents enrolled. Subjects who were
randomized to use MMH were asked to create a medication schedule and receive SMS
reminders at designated medication administration times for 3 weeks. Control
subjects received action lists as a part of their usual care. Primary outcome
measures included MMH usage patterns and self-reports of system usability,
medication adherence, asthma control, self-efficacy, and quality of life.
RESULTS: Eighty-nine subjects completed the study, of whom 46 were randomized to
the intervention arm. Compared to controls, we found improvements in
self-reported medication adherence (P = .011), quality of life (P = .037), and
self-efficacy (P = .016). Subjects reported high satisfaction with MMH; however,
the level of system usage varied widely, with lower use among African American
patients.
CONCLUSIONS: MMH was associated with improved medication adherence, perceived
quality of life, and self-efficacy.Trial Registration This project was registered
under http://clinicaltrials.gov/ identifier NCT01730235.
© The Author 2015. Published by Oxford University Press on behalf of the American
Medical Informatics Association. All rights reserved. For Permissions, please
email: journals.permissions@oup.com.
DOI: 10.1093/jamia/ocv158
PMCID: PMC4901375
PMID: 26661717 [Indexed for MEDLINE]
Association Between Self-Reported Adherence and HIV Viral Load Suppression Among
Older Children and Adolescents.
Author information:
(1)*Biomedical Research and Training Institute, Harare, Zimbabwe †London School
of Hygiene and Tropical Medicine, London, United Kingdom.
DOI: 10.1097/QAI.0000000000001501
PMCID: PMC5638017
PMID: 28708812 [Indexed for MEDLINE]
Author information:
(1)Department of Community and Preventive Medicine, School Of Medicine, Hamadan
University of Medical Sciences, Hamadan, Iran. pirdehghan93@gmail.com.
(2)Department of Community and Preventive Medicine, School Of Medicine,
University of Shahid Sadoughi, Yazd, Iran.
van der Laan DM(1), Elders PJM(2), Boons CCLM(1), Nijpels G(2), van Dijk L(3),
Hugtenburg JG(1).
Author information:
(1)Department of Clinical Pharmacology and Pharmacy and the Amsterdam Public
Health Research Institute, VU University Medical Center, Amsterdam, Netherlands.
(2)Department of General Practice and Elderly Care Medicine and the Amsterdam
Public Health Research Institute, VU University Medical Center, Amsterdam,
Netherlands.
(3)Netherlands Institute for Health Services Research, Utrecht, Netherlands.
DOI: 10.3389/fphar.2018.01057
PMCID: PMC6169131
PMID: 30319409
795. Drug Discov Ther. 2018 Mar 19;12(1):16-20. doi: 10.5582/ddt.2017.01073. Epub
2018
Feb 25.
Generic selection criteria for safety and patient benefit [VII]: Comparing the
physicochemical and pharmaceutical properties of brand-name and generic
terbinafine hydrochloride cream.
Nozawa M(1), Goto M(1), Wada Y(2), Kumazawa M(3), Shimokawa KI(4), Ishii F(2).
Author information:
(1)Triad Japan Co., Ltd.
(2)Department of Self-medication and Health Care Sciences, Meiji Pharmaceutical
University.
(3)Department of Mathematical Science, Meiji Pharmaceutical University.
(4)Department of Pharmaceutical Sciences, Meiji Pharmaceutical University.
We measured and compared the physicochemical properties (pH, yield value, and
squeeze force) of a drug for dermatomycosis, terbinafine hydrochloride-containing
cream (brand-name product), and 12 generic products to clarify the
characteristics of each product. On pH measurement, the pH value of the
brand-name product, Lamisil, was 4.8, and those of the generic products ranged
from 4.3 to 5.5, showing no marked difference. Furthermore, the yield value of
Lamisil, as an index of cream ductility, was 122.2 dyn/cm2, and those of the
generic products ranged from 42.1 to 1,621.5 dyn/cm2. In particular, the value of
a generic product, Taiyo (42.1 dyn/cm2), was significantly lower, whereas that of
another one, Viras (1,621.0 dyn/cm2), was significantly higher. In addition, the
squeeze force was measured by attaching a HapLog® to the thumb and second finger.
The value of Lamisil was 12.9 N, and those of the generic products ranged from
8.0 to 15.4 N. The values of generic products, Mylan (8.6 N), Tebinaceil (9.0 N),
and Kelger (8.0 N), were significantly lower, whereas that of another one, Viras
(15.4 N), was significantly higher. These results showed that there were marked
differences in the pharmaceutical properties between the generic and brand-name
products. The above pharmaceutical characteristics of drugs facilitated the
presentation of reasons for differences in the sense of use, which characterizes
external preparations, suggesting that products appropriate for individual
patients can be recommended.
DOI: 10.5582/ddt.2017.01073
PMID: 29479048 [Indexed for MEDLINE]
Author information:
(1)Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
DOI: 10.1016/j.htct.2017.11.009
PMCID: PMC6098173
PMID: 30128428
Author information:
(1)New York University College of Nursing, New York, NY (V.V.D.).
(2)University of North Carolina School of Nursing, Chapel Hill, NC (G.J.K.).
(3)Heart FailureTransplant Program, University of Pennsylvania, Philadelphia, PA
(J.W.).
(4)University of Pennsylvania School of Nursing, Philadelphia, PA (B.R.).
BACKGROUND: In the United States, the highest prevalence of heart failure (HF) is
in blacks followed by whites. Compared with whites, blacks have a higher risk of
HF-related morbidity and mortality and HF-related hospitalization. Little
research has focused on explaining the reasons for these disparities. The purpose
of this study was to examine racial differences in demographic and clinical
characteristics in blacks and whites with HF and to determine if these
characteristics influenced treatment, or together with treatment, influenced
self-care behaviors.
METHODS AND RESULTS: This was a secondary analysis of existing data collected
from adults (n=272) with chronic HF enrolled from outpatient sites in the
northeastern United States and followed for 6 months. After adjusting for
sociodemographic and clinical characteristics within reduced (HFrEF) and
preserved ejection fraction (HFpEF) groups, there were 2 significant racial
differences in clinical treatment. Blacks with HFrEF were prescribed ACE
inhibitors and hydralazine and isosorbide dinitrate (H-ISDN) more often than
whites. In the HFpEF group, blacks were taking more medications and were
prescribed digoxin and a diuretic when symptomatic. Deficits in HF knowledge and
decreased medication adherence, objectively measured, were more prominent in
blacks. These racial differences were not explained by sociodemographic or
clinical characteristics or clinical treatment variables. Premorbid intellect and
the quality of support received contributed to clinical treatment and self-care.
CONCLUSION: Although few differences in clinical treatment could be attributed
solely to race, knowledge about HF and medication adherence is lower in blacks
than whites. Further research is needed to explain these observations, which may
be targets for future intervention research.
© 2015 The Authors. Published on behalf of the American Heart Association, Inc.,
by Wiley Blackwell.
DOI: 10.1161/JAHA.114.001561
PMCID: PMC4579928
PMID: 25870187 [Indexed for MEDLINE]
798. Ther Adv Drug Saf. 2018 Mar;9(3):179-192. doi: 10.1177/2042098617746053. Epub
2017 Dec 22.
Rishoej RM(1), Hallas J(2), Juel Kjeldsen L(3), Thybo Christesen H(4),
Almarsdóttir AB(5).
Author information:
(1)Clinical Pharmacology and Pharmacy, Department of Public Health, University of
Southern Denmark, J. B. Winsløws Vej 19, 2., 5000 Odense C, Denmark.
(2)Clinical Pharmacology and Pharmacy, Department of Public Health, University of
Southern Denmark, Odense, Denmark.
(3)Amgros I/S, Copenhagen, Denmark.
(4)Hans Christian Andersen Children's Hospital, Odense University Hospital,
Odense, Denmark Department of Clinical Research, University of Southern Denmark,
Odense, Denmark.
(5)Social and Clinical Pharmacy, Department of Pharmacy, University of
Copenhagen, Copenhagen, Denmark.
DOI: 10.1177/2042098617746053
PMCID: PMC5810853
PMID: 29492247
799. Neurourol Urodyn. 2016 Aug;35(6):738-42. doi: 10.1002/nau.22798. Epub 2015 May
20.
Andy UU, Arya LA(1), Smith AL(2), Propert KJ(3), Bogner HR(4), Colavita K(1),
Harvie HS(1).
Author information:
(1)Division of Urogynecology, Department of Obstetrics and Gynecology, University
of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
(2)Division of Urology, Department of Surgery, University of Pennsylvania School
of Medicine, Philadelphia, Pennsylvania.
(3)Department of Biostatistics and Epidemiology, University of Pennsylvania
School of Medicine, Philadelphia, Pennsylvania.
(4)Department of Family Medicine and Community Health, University of Pennsylvania
School of Medicine, Philadelphia, Pennsylvania.
Comment in
Neurourol Urodyn. 2016 Sep;35(7):856.
J Urol. 2017 Jun;197(6):1525-1526.
DOI: 10.1002/nau.22798
PMCID: PMC4654718
PMID: 25995132 [Indexed for MEDLINE]
800. J Pharm Health Care Sci. 2018 Jul 3;4:16. doi: 10.1186/s40780-018-0112-4.
eCollection 2018.
Tominaga Y(1), Aomori T(2), Hayakawa T(2), Kijima N(3), Morisky DE(4), Takahashi
K(5), Mochizuki M(1)(2).
Author information:
(1)1Division of Hospital Pharmacy Science, Graduate School of Pharmaceutical
Sciences, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512 Japan.
(2)2Division of Hospital Pharmacy Science, Faculty of Pharmacy, Keio University,
1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512 Japan.
(3)3Psychological Laboratory, Keio University, 4-1-1 Hiyoshi, Kohoku-ku,
Yokohama, 223-8521 Japan.
(4)4Department of Community Health Sciences, UCLA Fielding School of Public
Health, 650 Charles E. Young Drive South, Los Angeles, CA 90095-1772 USA.
(5)5Department of Clinical Epidemiology and Biostatistics, Graduate School of
Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550 Japan.
DOI: 10.1186/s40780-018-0112-4
PMCID: PMC6029079
PMID: 29988655
Conflict of interest statement: The Ethics and Research Board of the Faculty of
Pharmacy, Keio University, approved this study protocol (approval nos. 161215–1
and 170120–1). The study objective and methods were explained to the participants
using written documents to obtain their signed consent after confirming their
sufficient understanding and agreement.DEM is the developer/owner of the
copyrighted MMAS diagnosed adherence assessment instrument and receives
royalities. He was not involved in the data analysis. The other authors declare
that they have no competing interests.Springer Nature remains neutral with regard
to jurisdictional claims in published maps and institutional affiliations.
Vissenberg C(1), Nierkens V(1), van Valkengoed I(1), Nijpels G(2), Uitewaal P(3),
Middelkoop B(4), Stronks K(1).
Author information:
(1)1 Department of Public Health, Academic Medical Centre, University of
Amsterdam, Amsterdam, The Netherlands.
(2)4 VU University Medical Centre, Amsterdam, The Netherlands.
(3)2 The Hague's Public Health Department, The Hague, The Netherlands.
(4)3 Leiden University Medical Centre, Leiden, The Netherlands.
AIMS: This paper aims to explore the effect of the social network based
intervention Powerful Together with Diabetes on diabetes self-management among
socioeconomically deprived patients. This 10-month group intervention targeting
patients and significant others aimed to improve self-management by stimulating
social support and diminishing social influences that hinder self-management.
METHODS: This intervention was evaluated in a quasi-experimental study using a
mixed methods approach. Of 131 socioeconomically deprived patients with
suboptimal glycaemic control, 69 were assigned to the intervention group and 62
to the control group (standard diabetes education). 27 qualitative in-depth
interviews with the participants and 24 with their group leaders were held to
study the subjective impact of the intervention. Further, self-management
behaviours (medication adherence, diet and physical activity) were assessed at
baseline, 10 and 16 months. Data were analysed using framework analyses and a
linear mixture model.
RESULTS: Qualitative data showed that the intervention group had a better
understanding of the way self-management influences diabetes. The intervention
group showed more complex self-management behaviours, such as planning ahead,
seeking adequate food and physical activity alternatives, and consistently taking
their diabetes into consideration when making choices. In participants with
complete follow-up data, we found a significant increase in physical activity in
the intervention group (3.78 vs. 4.83 days) and no changes in medication
adherence and diet.
CONCLUSIONS: This study indicates that an intensive support group and
simultaneously involving significant others might improve diabetes
self-management behaviours among socioeconomically deprived patients. More
studies are needed to justify further implementation of the intervention. This
study is registered in the Dutch Trial Register NTR1886.
http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1886.
DOI: 10.1177/1403494817701565
PMCID: PMC5544123
PMID: 28707567 [Indexed for MEDLINE]
Pegha Moukandja I(1)(2), Biteghe Bi Essone JC(1)(2), Sagara I(3), Kassa Kassa
RF(1), Ondzaga J(1), Lékana Douki JB(1)(2)(4), Bouyou Akotet M(4), Nkoghe Mba
D(1), Touré Ndouo FS(1).
Author information:
(1)Centre International de Recherches Médicales de Franceville (CIRMF) B.P. 769
Franceville, Gabon.
(2)Ecole Doctorale Régionale (EDR) en Infectiologie Tropicale, BP: 876
Franceville, Gabon.
(3)Département d'Epidémiologie et des Affections Parasitaires, MRTC, Faculté de
Médecine et d'Odontostomatologie, Université de Bamako, BP 1805 Bamako, Mali.
(4)Département de Parasitologie-Mycologie Médecine Tropicale, Faculté de
Médecine, Université des Sciences de la Santé, B.P. 4009 Libreville, Gabon.
DOI: 10.1371/journal.pone.0153899
PMCID: PMC4881998
PMID: 27228058 [Indexed for MEDLINE]
803. Trop Med Health. 2017 Dec 4;45:31. doi: 10.1186/s41182-017-0070-9. eCollection
2017.
Awareness of malaria and treatment-seeking behaviour among persons with acute
undifferentiated fever in the endemic regions of Myanmar.
Naing PA(1), Maung TM(1), Tripathy JP(2), Oo T(1), Wai KT(1), Thi A(3).
Author information:
(1)Department of Medical Research, Ministry of Health and Sports, No. 5, Ziwaka
Road Dagon Township, Yangon, 11191 Myanmar.
(2)International Union Against Tuberculosis and Lung Disease, The Union
South-East Asia Regional Office, New Delhi, India.
(3)National Malaria Control Program, Ministry of Health and Sports, Naypyitaw,
Myanmar.
Background: Myanmar has a high burden of malaria with two-third of the population
at risk of malaria. One of the basic elements of the Roll Back Malaria Initiative
to fight against malaria is early diagnosis and treatment within 24 h of fever.
Public awareness about malaria is a key factor in malaria prevention and control
and in improving treatment-seeking behaviour.
Methods: A large community-based survey was carried out in 27 townships of
malaria endemic regions in Myanmar in 2015 which reported on the knowledge,
behaviour and practices around malaria in the general population. We used the
data already collected in this survey to assess (i) general public awareness of
malaria and (ii) treatment-seeking behaviour and associated factors among persons
with acute undifferentiated fever.
Results: A total of 6597 respondents from 6625 households were interviewed
(response rate of 99.5%). About 85% of the respondents were aware that mosquito
bite was the mode of transmission of malaria and 90% mentioned that malaria was
preventable. However, only 16% of the respondents knew about anti-malaria drug
resistance. There were certain misconceptions about the transmission of malaria
such as dirty water, same blood group, sharing shelter, sleeping/eating together
and poor hygiene. Health facility staff were the most common source of
information about malaria (80%). Nearly one-fourth (23%) of the respondents with
fever resorted to self-medication. Around 28% of the respondents with fever
underwent blood testing, less than half of whom (44%) were tested within 24 h.
Elderly age group, females, those with poor knowledge about malaria and those
residing in non-Regional Artemisinin Resistance Initiative townships were
associated with poor treatment-seeking behaviour in case of fever.
Conclusion: Although there is fair knowledge on mosquito bite as a mode of
transmission and prevention of malaria, there are some misconceptions about
transmission of malaria. Those having poor knowledge about malaria have poor
treatment-seeking behaviour. A considerable number of respondents seek care from
informal care providers and seek care late. Thus, there is a need to promote
awareness about the role of early diagnosis and appropriate treatment and address
misconceptions about transmission of malaria.
DOI: 10.1186/s41182-017-0070-9
PMCID: PMC5713003
PMID: 29213208
Linn AJ(1), Vandeberg L(1), Wennekers AM(2), Vervloet M(3), van Dijk L(3), van
den Bemt BJ(4).
Author information:
(1)Amsterdam School of Communication Research, University of Amsterdam Amsterdam,
Netherlands.
(2)Amsterdam School of Communication Research, University of AmsterdamAmsterdam,
Netherlands; The Netherlands Institute for Social ResearchDen Haag, Netherlands.
(3)Netherlands Institute for Health Services Research Utrecht, Netherlands.
(4)Department of Pharmacy and Department of Rheumatology, Sint
MaartenskliniekNijmegen, Netherlands; Department of Pharmacy, Radboud University
Medical CenterNijmegen, Netherlands.
Medication non-adherence is a major public health problem that has been termed an
'invisible epidemic.' Non-adherence is not only associated with negative clinical
consequences but can also result in substantial healthcare costs. Up to now,
effective adherence interventions are scarce and a more comprehensive model of
adherence determinants is required to target the determinants for not taking the
medication as prescribed. Current approaches only included explicit attitudes
such as self-reported evaluations of medication as determinants, neglecting the
role of associative processes that shape implicit attitudes. Implicit processes
can predict daily behavior more accurately than explicit attitudes. Our aim is to
assess explicit and implicit attitudes toward medication and explore the relation
with beliefs, adherence and clinical (laboratory) outcomes in chronically ill
patients. Fifty two Rheumatic Arthritis (RA) patients' attitudes toward
Methotrexate (MTX) were explicitly (self-reported) and implicitly
(Single-Category Implicit Association Test) assessed and related to the Beliefs
about Medicine Questionnaire, the Compliance Questionnaire on Rheumatology and
laboratory parameters [Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein
(CRP)]. Results show that explicit attitudes were positive and health-related.
Implicit attitudes were, however, negative and sickness-related. Half of the
patients displayed explicitly positive but implicitly negative attitudes.
Explicit attitudes were positively related to ESR. A positive relationship
between implicit attitudes and disease duration was observed. In this study, we
have obtained evidence suggesting that the measurement of implicit attitudes and
associations provides different information than explicit, self-reported
attitudes toward medication. Since patients' implicit attitudes deviated from
explicit attitudes, we can conclude that the relationship between implicit
attitudes and medication adherence is worthwhile to be further explored. With
this information we can improve our understanding of the subconscious, automatic
processes underlying adherence and we can develop interventions that target these
implicit attitudes.
DOI: 10.3389/fphar.2016.00233
PMCID: PMC4978711
PMID: 27559311
Otsu Y(1)(2), Kai M(1), Suematsu Y(3), Kiyomi F(4), Saku K(3), Kamimura H(1)(2),
Miura SI(3).
Author information:
(1)Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences.
(2)Division of Pharmacy.
(3)Department of Cardiology, Faculty of Medicine.
(4)Academia, Industry and Government Collaborative Research Institute of
Translational Medicine for Life Innovation, Fukuoka University, Fukuoka, Japan.
DOI: 10.1097/MD.0000000000015188
PMCID: PMC6504264
PMID: 31045761 [Indexed for MEDLINE]
Kahwati L(1), Viswanathan M(2), Golin CE(3), Kane H(2), Lewis M(2), Jacobs S(2).
Author information:
(1)RTI International, Research Triangle Park, NC, USA. lkahwati@rti.org.
(2)RTI International, Research Triangle Park, NC, USA.
(3)Departments of Medicine and Health Behavior, University of North Carolina,
Chapel Hill, NC, USA.
DOI: 10.1186/s13643-016-0255-z
PMCID: PMC4875709
PMID: 27209092 [Indexed for MEDLINE]
Eakin MN(1), Chung SE(2), Hoehn J(3), Borrelli B(4), Rand-Giovannetti D(5),
Riekert KA(2).
Author information:
(1)Division of Pulmonary and Critical Care Medicine, Johns Hopkins University,
Baltimore, MD, United States. Electronic address: Meakin1@jhmi.edu.
(2)Division of Pulmonary and Critical Care Medicine, Johns Hopkins University,
Baltimore, MD, United States.
(3)Department of Psychology, University of Maryland, Baltimore County, Baltimore,
MD, United States.
(4)Boston University, Henry M Goldman School of Dental Medicine, Boston, MA,
United States.
(5)Department of Psychology, University of Hawai'i at Mānoa, Honolulu, HI, United
States.
BACKGROUND: Beliefs about medication have been associated with adherence in other
diseases but there are no existing disease-specific medication beliefs
questionnaires for CF. This mixed-methods validated the Cystic Fibrosis
Medication Belief Questionnaire (CF-MBQ), based on social cognitive theory.
METHODS: Based on previous research, items were developed for five domains:
motivation, self-efficacy, perceived importance, and decisional balance to take
or miss medications. Cognitive interviews were conducted with 15 adult patients
with CF to refine item development. 128 patients with CF completed an online
survey and objective medication adherence was measured using pharmacy refill
data.
RESULTS: The five subscales demonstrated strong psychometric properties, with
adequate-to-good internal consistency scores. More importantly, each domain
demonstrated construct validity with adherence.
CONCLUSIONS: These theoretically-derived measures may be important for clinical
purposes to provide guidance on appropriate interventions to improve adherence
and for research to provide enhanced understanding on patient determinants of
medication adherence.
Copyright © 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All
rights reserved.
DOI: 10.1016/j.jcf.2017.05.001
PMCID: PMC5581993
PMID: 28549609 [Indexed for MEDLINE]
Alexander DS(1), Hogan SL(2), Jordan JM(3), DeVellis RF(3), Carpenter DM(1).
Author information:
(1)UNC Eshelman School of Pharmacy, Division of Pharmaceutical Outcomes and
Policy, Asheville.
(2)UNC Kidney Center.
(3)Thurston Arthritis Research Center, University of North Carolina, Chapel Hill,
NC, USA.
DOI: 10.2147/PPA.S115272
PMCID: PMC5238767
PMID: 28138225
Morrison VL(1), Holmes EA(2), Parveen S(1), Plumpton CO(2), Clyne W(3), De Geest
S(4), Dobbels F(4), Vrijens B(5), Kardas P(6), Hughes DA(7).
Author information:
(1)School of Psychology, Bangor University, Bangor, UK.
(2)Centre for Health Economics & Medicines Evaluation, Bangor University, Bangor,
UK.
(3)Keele University, Keele, Staffordshire, UK.
(4)University of Leuven, Leuven, Belgium.
(5)MWV Healthcare, Visé, Belgium.
(6)Medical University of Lodz, Lodz, Poland.
(7)Centre for Health Economics & Medicines Evaluation, Bangor University, Bangor,
UK. Electronic address: d.a.hughes@bangor.ac.uk.
DOI: 10.1016/j.jval.2014.12.013
PMID: 25773556 [Indexed for MEDLINE]
The association between hardship and self-rated health: does the choice of
indicator matter?
Author information:
(1)Assistant Professor, University of Washington, Tacoma, Social Work Program,
Tacoma, WA. Electronic address: geegee@uw.edu.
(2)Edward L. Schneider Assistant Professor of Gerontology, Leonard Davis School
of Gerontology, University of Southern California, Los Angeles, CA.
PURPOSE: The purpose of this study was to investigate the association between
four specific forms of hardship (difficulty paying bills, ongoing financial
stress, medication reduction due to cost, and food insecurity) and self-rated
health among older men and women.
METHODS: Cross-sectional logistic regression analysis was conducted using the
2010 wave of the Health and Retirement Study Leave-Behind Questionnaire (N =
7619) to determine the association between four hardship indicators and
self-rated health. Hardship indicators (difficulty paying bills, ongoing
financial stress, medication reduction due to cost, and food insecurity) were
dichotomized (0 = no hardship, 1 = yes hardship) for this analysis.
RESULTS: After adjusting for sociodemographic factors, participants reporting
difficulty paying bills had an 1.8 higher odds of reporting poor self-rated
health (95% confidence intervals [CI]: 1.57, 2.15) and those reporting taking
less medication due to cost had a 2.5 times higher odds of poor self-rated health
(95% CI: 1.97, 3.09) compared to those not reporting these hardships. When
stratified by gender, and adjusting for sociodemographic factors, men who took
less medication due to cost had a 1.93 higher odds of low self-rated health (95%
CI: 1.39, 2.67) and women who took less medications due to cost had a 2.9 higher
odds of reporting poor self-rated health (95% CI: 2.23, 2.70) compared to women
not reporting these hardships.
CONCLUSIONS: Research in this area can provide greater conceptual and measurement
clarity on the hardship experience and further elucidate the pathway between
specific hardships and poor health outcomes to inform intervention development.
DOI: 10.1016/j.annepidem.2018.03.013
PMCID: PMC5986601
PMID: 29656847 [Indexed for MEDLINE]
Prell T(1)(2), Schaller D(1), Perner C(1)(3), Franke GH(4), Witte OW(1)(2), Kunze
A(1), Grosskreutz J(1)(2).
Author information:
(1)Department of Neurology, Jena University Hospital, Jena, Germany,
tino.prell@med.uni-jena.de.
(2)Center for Healthy Aging, Jena University Hospital, Jena, Germany,
tino.prell@med.uni-jena.de.
(3)Center for Immunology and Inflammatory Diseases, Massachusetts General
Hospital, Harvard Medical School, Charlestown, MA, USA.
(4)University of Applied Sciences, Psychology of Rehabilitation, Stendal,
Germany.
DOI: 10.2147/PPA.S186732
PMCID: PMC6342145
PMID: 30697036
Bartlett Ellis RJ(1), Hill JH(#)(2)(3), Kerley KD(1), Sinha A(#)(4), Ganci
A(#)(5), Russell CL(6).
Author information:
(1)Science of Nursing Care Department, Indiana University School of Nursing,
Indianapolis, IN, United States.
(2)Department of Computer & Information Science, Purdue School of Science,
Indiana University-Purdue University, Indianapolis, IN, United States.
(3)Center for Software and Innovation, Purdue School of Science, Indiana
University-Purdue University, Indianapolis, IN, United States.
(4)Richard L Roudebush VA Medical Center, Division of Nephrology, Indiana
University, Indianapolis, IN, United States.
(5)Visual Communication Design, Herron School of Art and Design, Indiana
University-Purdue University Indianapolis, Indianapolis, IN, United States.
(6)School of Nursing and Health Studies, University of Missouri-Kansas City,
Kansas City, MO, United States.
(#)Contributed equally
©Rebecca J Bartlett Ellis, James H Hill, K Denise Kerley, Arjun Sinha, Aaron
Ganci, Cynthia L Russell. Originally published in JMIR Formative Research
(http://formative.jmir.org), 25.06.2019.
DOI: 10.2196/13558
PMCID: PMC6614996
PMID: 31237568
Turan B(1), Fazeli PL(2), Raper JL(3), Mugavero MJ(3), Johnson MO(4).
Author information:
(1)Department of Psychology.
(2)Family, Community and Health Systems Department.
(3)Department of Medicine.
(4)Department of Medicine, University of California.
DOI: 10.1037/hea0000356
PMCID: PMC5033657
PMID: 27089459 [Indexed for MEDLINE]
Author information:
(1)University Hospitals Birmingham NHS Foundation Trust, Edgbaston, Birmingham,
B15 2WB, United Kingdom.
(2)Primary Care Clinical Sciences, School of Health & Population Sciences,
University of Birmingham, Birmingham, B15 2TT, United Kingdom.
(3)University Hospitals Birmingham NHS Foundation Trust, Edgbaston, Birmingham,
B15 2WB, United Kingdom; School of Clinical and Experimental Medicine, College of
Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United
Kingdom.
DOI: 10.1371/journal.pone.0113912
PMCID: PMC4252074
PMID: 25463269 [Indexed for MEDLINE]
Wouters H(1)(2), Rhebergen D(3), Vervloet M(4), Egberts A(5)(6), Taxis K(7), van
Dijk L(7)(4), Gardarsdottir H(5)(6)(8).
Author information:
(1)Department of Pharmacotherapy, Pharmacoepidemiology and Pharmacoeconomics
(PTEE), Faculty of Science and Engineering, Groningen Research Institute of
Pharmacy, University of Groningen, Groningen, The Netherlands. j.wouters@umcg.nl.
(2)Department of General Practice and Elderly Care Medicine, University Medical
Center Groningen, University of Groningen, Oostersingel, Building 50, P.O. Box
196, 9700 AD, Groningen, The Netherlands. j.wouters@umcg.nl.
(3)Department of Old Age Psychiatry, InGeest Specialized Mental Health Care,
Amsterdam UMC location VU Medical Center, Amsterdam, The Netherlands.
(4)Nivel Netherlands Institute for Health Services Research, Utrecht, The
Netherlands.
(5)Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of
Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University,
Utrecht, The Netherlands.
(6)Department of Clinical Pharmacy, Division Laboratory and Pharmacy, University
Medical Center Utrecht, Utrecht, The Netherlands.
(7)Department of Pharmacotherapy, Pharmacoepidemiology and Pharmacoeconomics
(PTEE), Faculty of Science and Engineering, Groningen Research Institute of
Pharmacy, University of Groningen, Groningen, The Netherlands.
(8)Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavík, Iceland.
Author information:
(1)Erasmus MC, University Medical Center Rotterdam, Department of Hospital
Pharmacy, Rotterdam, The Netherlands.
(2)Erasmus MC, University Medical Center Rotterdam, Department Child and
Adolescent Psychiatry, Rotterdam, The Netherlands.
DOI: 10.2147/PPA.S200058
PMCID: PMC6660631
PMID: 31413546
Author information:
(1)GlaxoSmithKline, Philadelphia, Pennsylvania. Electronic address:
cvs2@cornell.edu.
(2)Harris Poll, Rochester, New York.
(3)GlaxoSmithKline, King of Prussia, Pennsylvania.
(4)GlaxoSmithKline, Uxbridge, United Kingdom.
PURPOSE: This study explored the barriers that adult Americans experience when
taking injectable medications for type 2 diabetes, from the time of filling the
initial prescription through the decision to discontinue the medication.
METHODS: An Internet-based survey was conducted in 2 waves among adult patients
(N = 2000) who had received a physician prescription for insulin, liraglutide, or
exenatide once weekly (QW), regardless of whether the prescription was filled by
a pharmacy. In wave 1, patients were surveyed on their medication history and
experience and, if relevant, the medication discontinuation process. Those still
taking their injectable medication at the time of wave 1 were contacted 6 months
later (wave 2, n = 585) to assess any changes in their medication experience.
FINDINGS: Among patients who delayed filling their prescription by ≥1 week, cost
was a common reason for delay for refilling of liraglutide (63%) and exenatide QW
(49%). The most commonly reported barrier to maintaining injectable medication
was injection concerns (42%) such as aversion to needles, pain, or needle size.
Lack of perceived need was the most common reason for discontinuation for basal
(47%) and prandial/premixed (44%) insulin. For liraglutide, the most common
reason for discontinuation was experiencing an adverse event (33%); for exenatide
QW, it was injection concerns (38%).
IMPLICATIONS: The diverse barriers we identified underscore the need for better
patient-prescriber communication to ensure that newly prescribed injectable
medications are consistent with a patient's ability or willingness to manage
them, to appropriately set expectations about medications, and to address new
barriers that arise during the course of treatment.
DOI: 10.1016/j.clinthera.2016.05.009
PMID: 27364806 [Indexed for MEDLINE]
Author information:
(1)a Department of Community Health Systems , University of California , San
Francisco , CA , USA.
(2)b Department of Family Health Care Nursing , University of California , San
Francisco , CA , USA.
DOI: 10.1080/09540121.2016.1146401
PMCID: PMC4917432
PMID: 26908228 [Indexed for MEDLINE]
A Medication Adherence App for Children With Sickle Cell Disease: Qualitative
Study.
Author information:
(1)Health Behaviour and Interventions Research, Faculty of Health and Life
Sciences, Coventry University, Coventry, United Kingdom.
(2)Public Health Warwickshire, Warwickshire County Council, Warwick, United
Kingdom.
(3)Klinik für Pädiatrie mS, Onkologie/Hämatologie, Charité-Universitätsmedizin
Berlin, Berlin, Germany.
(4)Division of Psychiatry, University College London, London, United Kingdom.
(5)Research and Development Department, North East London Foundation Trust,
Goodmayes Hospital, Essex, United Kingdom.
(6)Amsterdam Street Children's Hospital, Cologne, Germany.
BACKGROUND: Young people with sickle cell disease (SCD) often demonstrate low
medication adherence and low motivation for effectively self-managing their
condition. The growing sophistication of mobile phones and their popularity among
young people render them a promising platform for increasing medication
adherence. However, so far, few apps targeting SCD have been developed from
research with the target population and underpinned with theory and evidence.
OBJECTIVE: The aim of this study was to develop a theory-and-evidence-based
medication adherence app to support children and adolescents with SCD.
METHODS: The Behavior Change Wheel (BCW), a theoretically based intervention
development framework, along with a review of the literature, 10 interviews with
children and adolescents with SCD aged between 12 and 18 years, and consultation
with experts informed app development. Thematic analysis of interviews provided
relevant theoretical and evidence-based components to underpin the design and
development of the app.
RESULTS: Findings suggested that some patients had lapses in memory for taking
their medication (capability); variation in beliefs toward the effectiveness of
medication and confidence in self-managing their condition (motivation); a
limited time to take medication; and barriers and enablers within the changing
context of social support during the transition into adulthood (opportunity).
Steps were taken to select the appropriate behavioral change components
(involving behavior change techniques [BCTs] such as information on antecedents,
prompts/cues; self-monitoring of the behavior; and social support) and translate
them into app features designed to overcome these barriers to medication
adherence.
CONCLUSIONS: Patients with SCD have complex barriers to medication adherence
necessitating the need for comprehensive models of behavior change to analyze the
problem. Children and adolescents require an app that goes beyond simple
medication reminders and takes into account the patient's beliefs, emotions, and
environmental barriers to medication adherence.
DOI: 10.2196/mhealth.8130
PMCID: PMC6604509
PMID: 31215518
Yin T(1), Yin DL(1), Xiao F(1), Xin QQ(1), Li RL(1), Zheng XG(1), Yang HM(1),
Wang LH(1)(2), Ding XY(2), Chen BW(1)(2).
Author information:
(1)Department of Health Development, Capital Institute of Pediatrics.
(2)Community Health Association of China, Beijing, China.
The objective of this study was to examine the association between patient
satisfaction with community health service (CHS) and self-management behaviors in
patients with type 2 diabetes mellitus (T2DM).In all, 1691 patients with T2DM
from 8 community health centers in 5 provinces in China participated in the
present study. The dependent variables included 4 measures of self-management
behaviors: regular self-monitoring of blood glucose (SMBG), prescribed medication
adherence, recommended dietary changes, and regular exercise. The independent
variable was patient satisfaction with CHS. Multivariable logistic regression
models were performed to examine the association between patient satisfaction
with CHS and self-management behaviors.The mean satisfaction score in the
participants was 3.14 (out of a maximum of 5). After adjusting for covariates
including demographic factors, health status, health knowledge, and socioeconomic
status (SES), diabetic patients with high CHS satisfaction had better medication
adherence (odds ratio [OR] 1.25, 95% confidence interval [CI] 1.02-1.55),
increased exercise management (OR 1.19, 95% CI 1.06-1.35), and more SMBG (OR
1.16, 95% CI 1.03-1.32); all these associations varied across SES groups. The
association between satisfaction and medication adherence was significant among
participants younger than 65 years with lower education (OR 2.15, 95% CI
1.37-3.37), income (OR 1.62, 95% CI 1.13-2.32), and lower-status occupations (OR
1.69, 95% CI 1.16-2.47). Among participants younger than 65 years and had lower
education attainment, the association between satisfaction and diet management
was observed. There were positive associations between satisfaction and regular
exercise among subgroups of participants younger than 65 years, except for lower
education group. A significant association between satisfaction and SMBG among
participants ≥65 years old, who also had lower SES and higher-status occupations,
was also observed.The study findings suggested that T2DM patient satisfaction
with CHS was moderate. High satisfaction with CHS indicated better medication
adherence, exercise management, and SMBG, and these associations varied by SES.
DOI: 10.1097/MD.0000000000015849
PMID: 31145334 [Indexed for MEDLINE]
Kosse RC(1), Bouvy ML(1), de Vries TW(2), Kaptein AA(3), Geers HC(1), van Dijk
L(4), Koster ES(1).
Author information:
(1)Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute
for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht.
(2)Department of Paediatrics, Medical Center Leeuwarden, Leeuwarden.
(3)Medical Psychology, Leiden University Medical Center, Leiden.
(4)NIVEL, the Netherlands Institute for Health Services Research, Utrecht, the
Netherlands.
DOI: 10.2147/PPA.S124615
PMCID: PMC5360404
PMID: 28356720
Revisiting the internal consistency and factorial validity of the 8-item Morisky
Medication Adherence Scale.
Zongo A(1), Guénette L(1), Moisan J(1), Guillaumie L(2), Lauzier S(1), Grégoire
JP(1).
Author information:
(1)Faculty of Pharmacy, Laval University, Quebec City, QC, Canada; Population
Health and Optimal Health Practices Research Unit, CHU de Québec - Université
Laval Research Centre, Quebec City, QC, Canada; Chair on adherence to treatments,
Laval University, Quebec City, QC, Canada.
(2)Population Health and Optimal Health Practices Research Unit, CHU de Québec -
Université Laval Research Centre, Quebec City, QC, Canada; Chair on adherence to
treatments, Laval University, Quebec City, QC, Canada; Faculty of Nursing, Laval
University, Quebec City, QC, Canada.
DOI: 10.1177/2050312116674850
PMCID: PMC5117245
PMID: 27895914
Author information:
(1)Department of Internal Medicine, Mbarara University of Science and Technology,
Mbarara, Uganda.
(2)Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston,
Massachusetts, United States of America.
(3)Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts,
United States of America.
Erratum in
PLoS One. 2017 Oct 31;12 (10 ):e0187620.
DOI: 10.1371/journal.pone.0158499
PMCID: PMC4930194
PMID: 27367542 [Indexed for MEDLINE]
Author information:
(1)Purdue University College of Pharmacy, West Lafayette, Indiana.
(2)Editorial Board Member, American Journal of Pharmaceutical Education,
Arlington, Virginia.
(3)University of Michigan Hospital, Ann Arbor, Michigan.
Objective. To compare pharmacy students' perceptions with patients' reasons for
medication non-adherence. Methods. Pharmacy students completing an experiential
rotation recruited patients exhibiting medication non-adherence from community
pharmacies and asked them to respond to statements about reasons for their
medication non-adherence. Patient responses were ranked in order of prevalence
and compared to self-reported student perceptions on reasons for non-adherence.
Results. There was a significant difference between patients' and students'
rankings of reasons for medication non-adherence. Significant factors for
patients included medications that interfere with lifestyle, sexual health and
drinking alcohol; whereas, students believed that cognitive-related issues were
patients' primary reasons for non-adherence to their medications. Conclusion.
Educational opportunities to reflect on and discuss differing perspectives should
be provided in the pharmacy curriculum to better equip students to address
medication adherence issues and improve patient care.
DOI: 10.5688/ajpe6444
PMCID: PMC6291675
PMID: 30559498
Quit outcomes among clients ineligible for cessation medication through the state
quitline: a retrospective, observational study.
Lent AB(1), O'Connor PA(2), Reikowsky RC(3), Nair US(3), Bell ML(4).
Author information:
(1)Health Promotion Sciences, University of Arizona, Mel and Enid Zuckerman
College of Public Health, 1295 N Martin Ave, Tucson, AZ, 85724, USA.
adriennelent@email.arizona.edu.
(2)Biostatistics, University of Arizona, Mel and Enid Zuckerman College of Public
Health, 1295 N Martin Ave, Tucson, AZ, 85724, USA.
(3)Health Promotion Sciences, University of Arizona, Mel and Enid Zuckerman
College of Public Health, 1295 N Martin Ave, Tucson, AZ, 85724, USA.
(4)Epidemiology and Biostatistics, University of Arizona, Mel and Enid Zuckerman
College of Public Health, 1295 N Martin Ave, Tucson, AZ, 85724, USA.
DOI: 10.1186/s12889-018-5923-6
PMCID: PMC6086054
PMID: 30097065
Author information:
(1)Oulu University Hospital, Oulu, Finland; sari.hirsikangas@ppshp.fi.
(2)National Institute for Health and Welfare, Oulu, Finland.
(3)Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.
(4)Research Group of Nursing Science and Health Management, University of Oulu,
Oulu, Finland.
(5)Northern Ostrobothnia Hospital District, Finland.
OBJECTIVES: The aim of the study was to describe adherence to health regimens and
the factors associated with it among adult frequent attenders (FAs).
DESIGN: This was a cross-sectional study. The study sample consisted of 462
healthcare FAs in 7 municipal health centres in northern Finland. An FA is a
person who has had 8 or more outpatient visits to a GP (in a health centre) or 4
or more outpatient visits to a university hospital during 1 year. The main
outcome was self-reported adherence to health regimens.
RESULTS: Of the FAs, 82% adhered well to their health regimens. Carrying out
self-care, medical care and feeling responsible for self-care were the most
significant predictors to good adherence in all models. No significant
differences in adherence were found in male and female subjects, age groups or
educational levels. Support from healthcare providers and support from relatives
were not significant predictors of good adherence.
CONCLUSION: FAs in Finland adhere well to health regimens and exceptionally well
to medication. Variables that predict the best adherence of FAs to health
regimens are carrying out self-care, receiving medical care and feeling
responsible for self-care.
DOI: 10.3402/ijch.v75.30726
PMCID: PMC4800284
PMID: 26996780 [Indexed for MEDLINE]
Author information:
(1)Department of Psychiatry, Korea University Guro Hospital, Korea University
College of Medicine.
DOI: 10.9758/cpn.2019.17.2.288
PMCID: PMC6478086
PMID: 30905129
Author information:
(1)School of Social Service Administration, University of Chicago, Chicago,
Illinois; STI/HIV Intervention Network, University of Chicago, Chicago, Illinois;
Third Coast Center for AIDS Research, University of Chicago and Northwestern
University, Chicago, Illinois; Chicago Center for HIV Elimination, University of
Chicago, Chicago, Illinois. Electronic address: d-voisin@uchicago.edu.
(2)Center for AIDS Intervention Research, Department of Psychiatry and Behavioral
Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
(3)Department of Social Welfare, Chungwoon University, Hongseong, South Korea.
(4)Third Coast Center for AIDS Research, University of Chicago and Northwestern
University, Chicago, Illinois; Department of Medicine, University of Chicago,
Chicago, Illinois; Department of Public Health Sciences, University of Chicago,
Chicago, Illinois.
PURPOSE: Young black men who have sex with men (YBMSM) experience poorer
antiretroviral therapy (ART) medication adherence relative to their white
counterparts. However, few studies have longitudinally examined factors that may
correlate with various classifications of ART adherence among this population,
which was the primary aim of this study.
METHODS: Project nGage was a randomized controlled trial conducted across five
Chicago clinics from 2012 to 2015. Survey and medical records data were collected
at baseline and 3- and 12-month periods to assess whether psychological distress,
HIV stigma, substance use, family acceptance, social support, and self-efficacy
predicted ART medication adherence among 92 YBMSM ages 16-29 years.
RESULTS: Major results controlling for the potential effects of age, education
level, employment, and intervention condition indicated that participants with
high versus low medication adherence were less likely to report daily/weekly
alcohol or marijuana use, had higher family acceptance, and exhibited greater
self-efficacy.
CONCLUSIONS: These findings identity important factors that can be targeted in
clinical and program interventions to help improve ART medication adherence for
YBMSM.
DOI: 10.1016/j.jadohealth.2016.10.428
PMCID: PMC5366075
PMID: 28043754 [Indexed for MEDLINE]
Exploring medicines management by COPD patients and their social networks after
hospital discharge.
Author information:
(1)Division of Pharmacy and Optometry, School of Health Sciences, Faculty of
Biology, Medicine and Health, The University of Manchester, Manchester, UK.
ellen.schafheutle@manchester.ac.uk.
(2)Division of Pharmacy and Optometry, School of Health Sciences, Faculty of
Biology, Medicine and Health, The University of Manchester, Manchester, UK.
DOI: 10.1007/s11096-018-0688-7
PMCID: PMC6208597
PMID: 30056568 [Indexed for MEDLINE]
830. Headache. 2016 Jul;56(7):1137-46. doi: 10.1111/head.12836. Epub 2016 May 11.
Kroon Van Diest AM(1), Ramsey R(1), Aylward B(2)(3), Kroner JW(1), Sullivan
SM(1), Nause K(1), Allen JR(1), Chamberlin LA(1), Slater S(1)(4)(5), Hommel
K(1)(5), LeCates SL(6)(4), Kabbouche MA(6)(4)(5), O'Brien HL(6)(4)(5), Kacperski
J(6)(4)(5), Hershey AD(6)(4)(5), Powers SW(1)(4)(5).
Author information:
(1)Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's
Hospital Medical Center, Cincinnati, OH, USA.
(2)Department of Pediatrics, Emory University School of Medicine, Atlanta, GA,
USA.
(3)Sibley Heart Center Cardiology, Children's Healthcare of Atlanta, Atlanta, GA,
USA.
(4)Headache Center, Cincinnati Children's Hospital Medical Center, Cincinnati,
OH, USA.
(5)Department of Pediatrics, University of Cincinnati College of Medicine,
Cincinnati, OH, USA.
(6)Division of Neurology, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH, USA.
DOI: 10.1111/head.12836
PMCID: PMC4955694
PMID: 27167502 [Indexed for MEDLINE]
Author information:
(1)University of Colorado, Aurora, Colorado.
DOI: 10.5688/ajpe81236
PMCID: PMC5374925
PMID: 28381896 [Indexed for MEDLINE]
Amer FA(1), Mohamed MS(2), Elbur AI(3), Abdelaziz SI(4), Elrayah ZA(5).
Author information:
(1)Department of Clinical Pharmacy, Faculty of Pharmacy, University of Khartoum,
Khartoum, (Sudan). bakarelbu@yahoo.co.uk.
(2)Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum,
Khartoum, (Sudan). msmohammed@uofk.edu.
(3)Department of Pharmacy Practice, College of Clinical Pharmacy, Imam
Abdulrahman Bin Faisal University. Dammam (Saudi Arabia). aisaeed@iau.edu.sa.
(4)Department of medicine, Faculty of Medicine, University of Khartoum. Khartoum
(Sudan). sulafibrahim1@gmail.com.
(5)Jabir Abu Elizz Diabetes Centre. Khartoum (Sudan). znab12@gmail.com.
DOI: 10.18549/PharmPract.2018.04.1274
PMCID: PMC6322981
PMID: 30637026
Author information:
(1)Johns Hopkins University School of Medicine, Department of Psychiatry and
Behavioral Sciences, United States.
(2)Johns Hopkins University School of Medicine, Department of Psychiatry and
Behavioral Sciences, United States. Electronic address: rkbrooner@jhmi.edu.
DOI: 10.1016/j.drugalcdep.2016.01.016
PMCID: PMC4772726 [Available on 2017-03-01]
PMID: 26851987 [Indexed for MEDLINE]
834. Pharmacy (Basel). 2017 Jul 11;5(3). pii: E39. doi: 10.3390/pharmacy5030039.
Author information:
(1)Albany College of Pharmacy and Health Sciences, 106 New Scotland Avenue,
Albany, NY 12208, USA. wendy.parker@acphs.edu.
(2)Albany College of Pharmacy and Health Sciences, 106 New Scotland Avenue,
Albany, NY 12208, USA. Kirsten.donato@acphs.edu.
(3)Albany College of Pharmacy and Health Sciences, 106 New Scotland Avenue,
Albany, NY 12208, USA. katie.cardone@acphs.edu.
(4)Albany College of Pharmacy and Health Sciences, 106 New Scotland Avenue,
Albany, NY 12208, USA. cerullij@gmail.com.
To determine the impact of advanced pharmacy practice experiences (APPE) on
student self-confidence related to medication therapy management (MTM),
fourth-year pharmacy students were surveyed pre/post APPE to: identify exposure
to MTM learning opportunities, assess knowledge of the MTM core components, and
assess self-confidence performing MTM services. An anonymous electronic
questionnaire administered pre/post APPE captured demographics, factors predicted
to impact student self-confidence (Grade point average (GPA), work experience,
exposure to MTM learning opportunities), MTM knowledge and self-confidence
conducting MTM using a 5-point Likert scale (1 = Not at all Confident; 5 =
Extremely Confident). Sixty-two students (26% response rate) responded to the
pre-APPE questionnaire and n = 44 (18%) to the post-APPE. Over 90% demonstrated
MTM knowledge and 68.2% completed MTM learning activities. APPE experiences
significantly improved students' overall self-confidence (pre-APPE = 3.27 (0.85
SD), post-APPE = 4.02 (0.88), p < 0.001). Students engaging in MTM learning
opportunities had higher self-confidence post-APPE (4.20 (0.71)) vs. those not
reporting MTM learning opportunities (3.64 (1.08), p = 0.05). Post-APPE, fewer
students reported MTM was patient-centric or anticipated engaging in MTM
post-graduation. APPE learning opportunities increased student self-confidence to
provide MTM services. However, the reduction in anticipated engagement in MTM
post-graduation and reduction in sensing the patient-centric nature of MTM
practice, may reveal a gap between practice expectations and reality.
DOI: 10.3390/pharmacy5030039
PMCID: PMC5622351
PMID: 28970451
The Association of Health Literacy with Illness and Medication Beliefs among
Patients with Chronic Obstructive Pulmonary Disease.
Kale MS(1), Federman AD(1), Krauskopf K(1), Wolf M(2), O'Conor R(2), Martynenko
M(1), Leventhal H(3), Wisnivesky JP(4).
Author information:
(1)Division of General Internal Medicine, Icahn School of Medicine at Mount
Sinai, New York, New York, United States of America.
(2)Division of General Internal Medicine, Feinberg School of Medicine,
Northwestern University, Chicago, Illinois, United States of America.
(3)Institute for Health, Health Care Policy and Aging Research, Rutgers, The
State University of New Jersey, New Brunswick, New Jersey, United States of
America.
(4)Division of General Internal Medicine, Icahn School of Medicine at Mount
Sinai, New York, New York, United States of America; Division of Pulmonary,
Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New
York, New York, United States of America.
DOI: 10.1371/journal.pone.0123937
PMCID: PMC4411058
PMID: 25915420 [Indexed for MEDLINE]
Author information:
(1)Behavioral Medicine Department, Butler Hospital, Providence, RI 02906, United
States; Warren Alpert Medical School of Brown University, Providence, RI 02912,
United States. Electronic address: Shannon_Kenney@brown.edu.
(2)Warren Alpert Medical School of Brown University, Providence, RI 02912, United
States; Stanley Street Treatment and Resources, Inc., Fall River, MA 02720,
United States.
(3)Behavioral Medicine Department, Butler Hospital, Providence, RI 02906, United
States.
(4)Behavioral Medicine Department, Butler Hospital, Providence, RI 02906, United
States; Boston University School of Public Health, Boston, MA 02118, United
States.
DOI: 10.1016/j.addbeh.2017.05.009
PMCID: PMC5510548
PMID: 28505487 [Indexed for MEDLINE]
Author information:
(1)Division of Social and Administrative Sciences, School of Pharmacy, University
of Wisconsin-Madison, Madison, Wisconsin, USA.
(2)Department of Pharmaceutical Sciences, College of Pharmacy, Roseman University
of Health Sciences, Utah, USA.
DOI: 10.1136/bmjopen-2018-022803
PMCID: PMC6254403
PMID: 30478112
838. Health Psychol. 2015 May;34(5):496-504. doi: 10.1037/hea0000136. Epub 2014 Aug
11.
Hilliard ME(1), Eakin MN(1), Borrelli B(2), Green A(1), Riekert KA(1).
Author information:
(1)Johns Hopkins University School of Medicine, Johns Hopkins Adherence Research
Center, Division of Pulmonary and Critical Care Medicine.
(2)Warren Alpert School of Medicine at Brown University.
DOI: 10.1037/hea0000136
PMCID: PMC4537164
PMID: 25110847 [Indexed for MEDLINE]
839. BMC Res Notes. 2017 Mar 21;10(1):131. doi: 10.1186/s13104-017-2454-7.
Islam SM(1)(2)(3), Biswas T(4), Bhuiyan FA(4), Mustafa K(5)(6), Islam A(7)(8).
Author information:
(1)NCD Program, International Center for Diarrhoeal Disease Research, Bangladesh
(ICDDR,B), 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh.
shariful.islam@icddrb.org.
(2)Center for International Health, Ludwig-Maximilians Univetsitat, Munich,
Germany. shariful.islam@icddrb.org.
(3)The George Institute for Global Health, University of Sydney, Sydney,
Australia. shariful.islam@icddrb.org.
(4)NCD Program, International Center for Diarrhoeal Disease Research, Bangladesh
(ICDDR,B), 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh.
(5)Department of Public Health, The University of Southern Mississippi,
Hattiesburg, MS, USA.
(6)Bangladesh University of Health Science (BUHS), Dhaka, Bangladesh.
(7)Faculty of Health, School of Health Policy and Management, York University,
Toronto, Canada.
(8)Department of Public Health, North South University, Dhaka, Bangladesh.
DOI: 10.1186/s13104-017-2454-7
PMCID: PMC5361713
PMID: 28327202 [Indexed for MEDLINE]
840. Libyan J Med. 2015 Dec 28;10:29797. doi: 10.3402/ljm.v10.29797. eCollection
2015.
Ashur ST(1), Shah SA(2), Bosseri S(3), Morisky DE(4), Shamsuddin K(2).
Author information:
(1)Department of Community Health, Universiti Kebangsaan Malaysia Medical Centre,
Kuala Lumpur, Malaysia; drsana04@yahoo.com.
(2)Department of Community Health, Universiti Kebangsaan Malaysia Medical Centre,
Kuala Lumpur, Malaysia.
(3)National Centre for Diabetes and Endocrinology, Tripoli, Libya.
(4)Department of Community Health Sciences, UCLA Fielding School of Public
Health, Los Angeles, CA, USA.
DOI: 10.3402/ljm.v10.29797
PMCID: PMC4695620
PMID: 26714569 [Indexed for MEDLINE]
Psychosocial factors are strongly associated with insomnia in users and nonusers
of prescribed sleep medication: evidence from the HUNT3 study.
Andenæs R(1), Helseth S(1), Misvær N(1), Småstuen MC(1), Ribu L(1).
Author information:
(1)Faculty of Health Sciences, Department of Nursing and Health Promotion, Oslo
and Akershus University College of Applied Sciences, Oslo, Norway.
OBJECTIVE: The aim of this study was to examine how neuroticism, stressful life
events, self-rated health, life satisfaction, and selected lifestyle factors were
related to insomnia both by sex and among users and nonusers of prescribed sleep
medication (PSM).
DESIGN: Cross-sectional data from the Norwegian Nord-Trøndelag Health Study
(HUNT3, 2006-2008), a population-based health survey, were linked to individual
data from the Norwegian Prescription Database.
METHODS: Logistic regression analyses were used to investigate the associations
between the selected variables and insomnia in both males and females and among
subjects using and not using PSM. Individuals were considered to have a
presumptive diagnosis of insomnia disorder if they reported difficulty with sleep
initiation, sleep maintenance, or early morning awakening several days per week
for the last 3 months. PSMs were categorized as anxiolytics or hypnotics; the
dose was estimated according to defined daily dose (DDD).
RESULTS: Of the total 50,805 participants, 6,701 (13.2%) used PSM. The
proportions of PSM users were larger among elderly participants. Increased risk
of insomnia was strongly associated with poor self-rated health and higher level
of neuroticism. These associations were evident for both sexes and were similar
among both users and nonusers of PSM. Low satisfaction with life was strongly
related to insomnia, but only among nonusers of PSM. Increased doses of PSM were
not associated with reduced likelihood of insomnia.
CONCLUSION: Insomnia is a problem among both users and nonusers of PSM and is
associated with psychosocial factors. Our findings suggest that successful
treatment for sleep problems should take individual variation into account, such
as age, sex, personality traits, satisfaction with life, and health perception.
DOI: 10.2147/JMDH.S116462
PMCID: PMC5077243
PMID: 27799781
White RO(1), Eden S(2), Wallston KA(3), Kripalani S(4), Barto S(5), Shintani
A(2), Rothman RL(4).
Author information:
(1)Division of Community Internal Medicine, Mayo Clinic, Jacksonville, USA;
Department of Family Medicine, Mayo Clinic, Jacksonville, USA. Electronic
address: white.richard@mayo.edu.
(2)Department of Biostatistics, Vanderbilt University, Nashville, USA.
(3)School of Nursing, Vanderbilt University Medical Center, Nashville, USA.
(4)Department of Medicine, Vanderbilt University Medical Center, Nashville, USA;
Institute for Medicine and Public Health, Vanderbilt University, Nashville, USA.
(5)Institute for Medicine and Public Health, Vanderbilt University, Nashville,
USA.
DOI: 10.1016/j.pec.2014.10.019
PMCID: PMC4282939
PMID: 25468393 [Indexed for MEDLINE]
Glycaemic control status among type 2 diabetic patients and the role of their
diabetes coping behaviours: a clinic-based study in Tripoli, Libya.
Ashur ST(1), Shah SA(1), Bosseri S(2), Fah TS(3), Shamsuddin K(4).
Author information:
(1)Department of Community Health, Universiti Kebangsaan Malaysia Medical Centre,
Kuala Lumpur, Malaysia.
(2)National Centre for Diabetes and Endocrinology, Tripoli, Libya.
(3)Department of Family Medicine, Universiti Kebangsaan Malaysia Medical Centre,
Kuala Lumpur, Malaysia.
(4)Department of Community Health, Universiti Kebangsaan Malaysia Medical Centre,
Kuala Lumpur, Malaysia; Khadijah@ppukm.ukm.edu.my.
DOI: 10.3402/ljm.v11.31086
PMCID: PMC4803895
PMID: 27005896 [Indexed for MEDLINE]
de Castro ML(1), Sanromán L(2), Martín A(3), Figueira M(4), Martínez N(3),
Hernández V(2), Del Campo V(5), Pineda JR(2), Martínez-Cadilla J(2), Pereira
S(2), Rodríguez Prada JI(2).
Author information:
(1)Aparato Digestivo, Hospital Álvaro Cunqueiro, España.
(2)Aparato Digestivo, Hospital Álvaro Cunqueiro.Fundación Biomédica Galicia
Sur.Complexo Hospitalario Universitario de Vig, España.
(3)Farmacia Hospitalaria, Hospital Álvaro Cunqueiro.Fundación Biomédica Galicia
Sur.Complexo Hospitalario Universitario de Vig, España.
(4)Aparato Digestivo, Hospital Álvaro Cunqueiro.Fundación Biomédica Galicia
Sur.Complexo Hospitalario Universitario de Vig.
(5)Epidemiología y Medicina Preventiva, Hospital Álvaro Cunqueiro.Fundación
Biomédica Galicia Sur.Complexo Hospitalario Universitario de Vig, España.
Comment in
Rev Esp Enferm Dig. 2017 Aug;109 (8):539-541.
DOI: 10.17235/reed.2017.5137/2017
PMID: 28679280 [Indexed for MEDLINE]
'The problem here is that they want to solve everything with pills': medication
use and identity among Mainland Puerto Ricans.
Author information:
(1)Northeastern University, Boston, USA.
(2)University of Massachusetts Lowell, Lowell, USA.
Taking medications are complex symbolic acts, infused with diverse meanings
regarding body and identity. This article focuses on the meanings of medications
for older Puerto Ricans living on the United States mainland, a population
experiencing stark health disparities. We aim to gain an understanding of the way
multiple cultural and personal meanings of medications are related to and
integrated in identity, and to understand how they are situated within Puerto
Rican culture, history and circumstance on the US mainland. Data is drawn from
thirty qualitative interviews, transcribed and translated, with older Puerto
Ricans living on mainland United States. Thematic Analysis indicated four
prevalent themes: embodiment of medication use; medications redefining self
through the fabric of daily life; healthcare experience defined through
medication; and medicine dividing the island and the mainland. While identity is
impacted by experience of chronic illness, the experience of medication
prescription and consumption is further related to the construction of the sense
of self in distinct ways. For these individuals, medication use captures the
dilemma of immigration. While cultural belonging and well-being remains on the
island of Puerto Rico, the mainland hosts both easier access to and excess
reliance on medication.
DOI: 10.1111/1467-9566.12240
PMCID: PMC4521983
PMID: 25720591 [Indexed for MEDLINE]
Author information:
(1)Hollytree Surgery, Farnham, Surrey.
(2)Independent consultant in public health, Farnham, Surrey.
(3)Insight 2 implement Ltd, Elstead, Surrey.
BACKGROUND: Most people with diabetes are not attaining desirable levels of HbA1c
(glycated haemoglobin), or of blood pressure and cholesterol, leaving them at
risk of developing complications.
AIM: To identify ways of improving diabetes control by gaining insight into
patients' attitudes/beliefs.
DESIGN AND SETTING: Questionnaires were offered to patients attending for a
diabetes review in the 24 GP practices of North East Hampshire and Farnham
Clinical Commissioning Group.
METHOD: Infrequent attenders were contacted by post. Volunteers then participated
in focus groups.
RESULTS: Self-reported medication adherence was good with 83% (98/118) of
responders recording ≥9 on a 10-point scale. Patients generally accepted they
'needed' and 'could take' medication. A substantial minority reported 'not
liking' taking tablets. Focus groups confirmed this and revealed a reluctance to
change lifestyle, with medication reported as a way to evade it. A total of 68
out of 112 responders (60.7%) knew their HbA1c value. However, focus groups
identified little understanding of HbA1c, with responders perceiving it as
medical jargon. Phrases such as 'stuck-on-sugar' or 'sugarload' were suggested as
being semantically easier to understand. The questionnaire revealed trust in
clinicians. This was confirmed in focus groups but confounded by frequent reports
of healthcare providers giving inadequate/incorrect advice.
CONCLUSION: Investment in lifestyle change is needed. Participants were reluctant
to change and saw medication as a way of avoiding it. HbA1c needs to be better
explained. Intuitive phrases such as 'stuck-on-sugar' or 'sugarload' could be
adopted into common parlance. Inadequate/incorrect advice seems to be hampering
diabetes management and there appears to be a need for more diabetes-trained
clinicians.
DOI: 10.3399/bjgp16X687589
PMCID: PMC5198664
PMID: 27884918 [Indexed for MEDLINE]
847. BMC Health Serv Res. 2017 Mar 14;17(1):197. doi: 10.1186/s12913-017-2135-1.
Li L(1), Lake R(2), Raban MZ(2), Byrne M(3), Robinson M(3), Westbrook J(2),
Baysari MT(2)(4).
Author information:
(1)Centre for Health Systems and Safety Research, Australian Institute of Health
Innovation, Faculty of Medicine and Health Sciences, Level 6, 75 Talavera Road,
Macquarie University, Sydney, NSW, 2109, Australia. ling.li@mq.edu.au.
(2)Centre for Health Systems and Safety Research, Australian Institute of Health
Innovation, Faculty of Medicine and Health Sciences, Level 6, 75 Talavera Road,
Macquarie University, Sydney, NSW, 2109, Australia.
(3)Healthdirect Australia, Sydney, NSW, Australia.
(4)Department of Clinical Pharmacology & Toxicology, St Vincent's Hospital,
Sydney, Australia.
BACKGROUND: Telenursing triage and advice services are increasingly being used to
deliver health advice. Medication-related queries are common, however little
research has explored the medication-related calls made to these services. The
aim of this study was to examine the profile of medication-related calls to a
national telenursing triage and advice service and the medications involved.
METHODS: This was a retrospective cohort study of medication-related calls
received by Australia's national helpline (healthdirect helpline) in 2014, which
provides free advice from registered nurses. We examined the volume of
medication-related calls over time, user profiles for patients and callers, and
call characteristics and we also investigated medications involved in the calls
by their generic names and therapeutic classes.
RESULTS: Of 675,774 calls, 3.8% (n = 25,744) were medication-related, which was
the largest category of calls. The average call length was 10 min. Over half of
callers (55.4%) were advised to deliver self-care. Of 7,459 calls where the
callers reported they did not know what to do prior to calling, 56.8% were
advised to self-care and 3.5% were transferred to the Poisons Information Centre
immediately. Of 1,277 calls where callers reported that they had originally
intended to call an ambulance or attend an emergency department (ED), none were
advised to do so. Advice most frequently requested was about analgesics and
antipyretics, followed by non-steroidal anti-inflammatory agents.
CONCLUSION: The telenursing triage and advice helpline offered quick and easily
accessible advice, and provided reassurance to patients and callers with
medication-related queries. The service also potentially diverted some patients
from attending an ED unnecessarily.
DOI: 10.1186/s12913-017-2135-1
PMCID: PMC5348865
PMID: 28288619 [Indexed for MEDLINE]
848. BMC Health Serv Res. 2015 Apr 10;15:153. doi: 10.1186/s12913-015-0809-0.
Author information:
(1)Institut für Pharmakoökonomie und Arzneimittellogistik (IPAM), Hochschule
Wismar, Philipp-Müller-Straße 12, Wismar, 23966, Germany.
sabrina.mueller@ipam-wismar.de.
(2)Institut für Community Medicine, Universitätsmedizin Greifswald, Greifswald,
Germany. thomas.kohlmann@uni-greifswald.de.
(3)Institut für Pharmakoökonomie und Arzneimittellogistik (IPAM), Hochschule
Wismar, Philipp-Müller-Straße 12, Wismar, 23966, Germany.
thomas.wilke@ipam-wismar.de.
DOI: 10.1186/s12913-015-0809-0
PMCID: PMC4422301
PMID: 25884193 [Indexed for MEDLINE]
849. BMC Health Serv Res. 2019 Jul 16;19(1):495. doi: 10.1186/s12913-019-4194-y.
Author information:
(1)Department of Nursing, Pukyong National University, 599-1, Daeyeon 3 dong,
Namgu, Busan, 48513, South Korea.
(2)College of Medicine, Dong-A University Hospital, 26 Daesingongwon-ro, Seo-gu,
Busan, 49201, South Korea. bbp2000@dau.ac.kr.
Akeroyd JM(1), Chan WJ(1), Kamal AK(1), Palaniappan L(1), Virani SS(1).
Author information:
(1)Julia M Akeroyd, Winston J Chan, Salim S Virani, the Health Policy, Quality
and Informatics Program, Michael E DeBakey Veterans Affairs Medical Center,
Health Services Research and Development Center for Innovations, Houston, TX
77030, United States.
DOI: 10.4330/wjc.v7.i12.938
PMCID: PMC4691821
PMID: 26730300
OBJECTIVES: This study aimed to explore the perspectives of children and parents
regarding: 1) pediatric patients' knowledge and medication use experiences for
chronic conditions; 2) how they want to learn about medicines; and 3) perceptions
of community pharmacist-provided counseling.
DESIGN: Qualitative study using semistructured interviews and thematic analyses.
SETTING: Three community pharmacies in 2 eastern states: one in rural western
North Carolina, and 2 in an urban region of western Pennsylvania.
PARTICIPANTS: A total of 39 study participants: 20 children using medications for
chronic conditions and 19 parents interviewed July-December 2015.
MAIN OUTCOME MEASURES: Child and parent perspectives regarding pediatric
medication use, knowledge, experiences, and pharmacist-provided patient
counseling.
RESULTS: Children and parents had similar perspectives on pediatric medication
use and pharmacist counseling experiences. Six themes emerged: 1) child's
knowledge, self-management, and medication use experiences; 2) essential
medication information and sources; 3) child's frequent absence from the
pharmacy; 4) patient counseling needs and recommendations; 5) use of interactive
technologies to facilitate learning about medicines; and 6) perceptions of
pharmacists. Participants reported that children were independently managing
their medications, although they had minimal knowledge about medicines. Children
and parents stated that the child's absence during medication pick-up at
pharmacies was a barrier to receiving counseling by pharmacists. Children were
comfortable and receptive to pharmacists educating them about their medicines,
particularly how medications affect the human body, how they were manufactured,
and research studies on their medications. Parents and children recommended the
use of interactive and educational technologies for pediatric counseling.
CONCLUSION: Children are frequently not present at pharmacies during prescription
pick-up; however, children and parents are comfortable with and receptive to
pediatric medication counseling by pharmacists. Interactive and educational
technologies need to be developed and used by pharmacists to facilitate
counseling and educate children about the effective and safe use of medicines.
DOI: 10.1016/j.japh.2016.08.019
PMID: 27843107 [Indexed for MEDLINE]
Author information:
(1)VA Boston Healthcare System, 150 S. Huntington Ave, Boston, MA 02130. E-mail:
amy.linsky@va.gov.
OBJECTIVES: Primary care providers (PCPs) and clinical pharmacists have concerns
about the adverse consequences of using medications inappropriately and generally
support the notion of reducing unnecessary drugs. Despite this attitude, many
factors impede clinicians' ability to discontinue medication in clinical
settings. We sought to develop a survey instrument that assesses PCPs' and
pharmacists' experiences, attitudes, and beliefs toward medication
discontinuation.
STUDY DESIGN: Survey development and psychometric assessment.
METHODS: Based on a conceptual framework, we developed a questionnaire and
surveyed a national sample of Department of Veterans Affairs PCPs with
prescribing privileges, including physicians, nurse practitioners, physician
assistants, and clinical pharmacy specialists. We randomly divided respondents
into derivation and validation samples and used iterations of multi-trait
analysis to assess the psychometric properties of the proposed measures.
Multivariable regression models identified factors associated with the outcome of
self-rated comfort with medication discontinuation.
RESULTS: Using established criteria for scale development, we identified 5
scales: Medication Characteristics, Current Patient Clinical Factors, Predictions
of Future Health States, Patients' Resources to Manage Their Own Health, and
Education and Experience. Three of these dimensions predicted providers'
self-rated comfort with making decisions to discontinue medication (Current
Patient Clinical Factors, Predictions of Future Health States, and Education and
Experience).
CONCLUSIONS: We developed a psychometrically sound instrument to measure
prescribers' attitudes toward, and experiences with, medication discontinuation.
This survey will enable identification of perceived barriers to, and facilitators
of, proactive discontinuation-an important step toward developing interventions
that improve the quality and safety of care in medication use.
Rogliani P(1), Ora J(2), Puxeddu E(1), Matera MG(3), Cazzola M(4).
Author information:
(1)Chair of Respiratory Medicine, Department of Systems Medicine, University of
Rome Tor Vergata, Rome, Italy; Division of Respiratory Medicine, Department of
Internal Medicine, University Hospital Tor Vergata, Rome, Italy.
(2)Division of Respiratory Medicine, Department of Internal Medicine, University
Hospital Tor Vergata, Rome, Italy.
(3)Chair of Pharmacology, Department of Experimental Medicine, University of
Campania "Luigi Vanvitelli", Naples, Italy.
(4)Chair of Respiratory Medicine, Department of Systems Medicine, University of
Rome Tor Vergata, Rome, Italy. Electronic address: mario.cazzola@uniroma2.it.
DOI: 10.1016/j.rmed.2017.06.007
PMID: 28732818 [Indexed for MEDLINE]
854. Respir Care. 2016 May;61(5):571-6. doi: 10.4187/respcare.04493. Epub 2016 Feb
9.
Burnett DM(1), Burns S(2), Merritt S(2), Wick J(3), Sharpe M(3).
Author information:
(1)University of Kansas Medical Center, Kansas City, Kansas. dburnett@kumc.edu.
(2)University of Central Missouri, Warrensburg, Missouri.
(3)University of Kansas Medical Center, Kansas City, Kansas.
Comment in
Respir Care. 2016 May;61(5):713.
DOI: 10.4187/respcare.04493
PMID: 26860398 [Indexed for MEDLINE]
Examining Adherence Among Challenging Patients in Public and Private HIV Care in
Argentina.
Author information:
(1)Department of Psychiatry & Behavioral Sciences, University of Miami Miller
School of Medicine, 1400 NW 10th Ave., Miami, FL, 33136, USA,
djones@med.miami.edu.
Treatment engagement, retention and adherence to care are required for optimal
HIV outcomes. Yet, patients may fall below the treatment recommendations for
achieving undetectable viral load or not be retained in care. This study examined
the most challenging patients in Buenos Aires, Argentina, those non-adherent to
HIV care. Men (n = 61) and women (n = 59) prescribed antiretrovirals (ARVs) and
non-adherent to treatment in the prior 3-6 months were enrolled and assessed
regarding adherence, knowledge, motivation and attitudes regarding treatment.
Private clinic patients had lower viral load and higher self-reported adherence
than public clinic patients. Motivations to be adherent and positive beliefs
regarding ARVs were associated with increased adherence in public clinic
participants. Increased self-efficacy was associated with increased adherence
among participants from both clinics. Results support patient and provider
interventions that strengthen the characteristics supporting adherence,
engagement and retention in public and private clinic settings.
DOI: 10.1007/s10461-015-1037-7
PMCID: PMC4553072
PMID: 25777507 [Indexed for MEDLINE]
Author information:
(1)College of Pharmacy, The University of Arizona, Tucson, Arizona USA.
DOI: 10.1186/s40545-016-0066-6
PMCID: PMC4839112
PMID: 27103997
Sevilla-Cazes J(1), Finkleman BS(2), Chen J(3), Brensinger CM(3), Epstein AE(4),
Streiff MB(5), Kimmel SE(6).
Author information:
(1)Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
(2)Perelman School of Medicine at the University of Pennsylvania, Philadelphia;
Center for Clinical Epidemiology and Biostatistics, Philadelphia, Penn; Center
for Therapeutic Effectiveness Research, Philadelphia, Penn.
(3)Perelman School of Medicine at the University of Pennsylvania, Philadelphia;
Center for Clinical Epidemiology and Biostatistics, Philadelphia, Penn.
(4)Perelman School of Medicine at the University of Pennsylvania, Philadelphia;
Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Penn.
(5)Johns Hopkins University School of Medicine, Baltimore, Md.
(6)Perelman School of Medicine at the University of Pennsylvania, Philadelphia;
Center for Clinical Epidemiology and Biostatistics, Philadelphia, Penn; Center
for Therapeutic Effectiveness Research, Philadelphia, Penn. Electronic address:
stevek@mail.med.upenn.edu.
DOI: 10.1016/j.amjmed.2017.03.038
PMCID: PMC5572106
PMID: 28454906 [Indexed for MEDLINE]
Zarcone J(1), Hagopian L(1), Ninci J(1), McKay C(1), Bonner A(1), Dillon C(1),
Hausman N(1).
Author information:
(1)Kennedy Krieger Institute and Johns Hopkins School of Medicine.
OBJECTIVES: The goal of this study was to develop and evaluate a tool to measure
the complexity and intensity of psychotropic medication interventions, behavioral
interventions, and issues related to crisis management for challenging behavior
using a standardized rating form.
METHOD: The Treatment Intensity Rating Form (TIRF) is a 10-item scale with three
categories: pharmacological interventions, behavior supports, and protective
equipment. In a retrospective review we examined the final treatment
recommendations for 74 individuals with self-injurious behavior (SIB) based on
psychiatric and behavioral notes and reports. We also compared whether TIRF
scores differed across individuals for whom SIB was maintained by social
reinforcement (e.g., to access attention or toys/activities, or escape from
tasks) versus those for whom SIB was maintained by automatic reinforcement (e.g.,
occurs independent of social variables, and is presumed to be maintained by
sensory reinforcement).
RESULTS: The TIRF was demonstrated to have strong inter-rater reliability (98%)
and appears to have good face validity. As hypothesized, individuals with SIB
maintained by automatic reinforcement had significantly more medication trials
(p=0.0005) and required more protective equipment than individuals with SIB
maintained by social reinforcement (p=0.0002). Antidepressant medication was used
more often with individuals with automatically reinforced SIB, although
antipsychotics and anticonvulsants were also commonly used across both groups.
CONCLUSION: Findings provide initial support for the TIRF's reliability, and face
validity as a measure the level of complexity of medical and behavioral treatment
plans - although additional research is needed to fully evaluate its psychometric
properties.
DOI: 10.1080/20473869.2016.1173316
PMCID: PMC5127402
PMID: 27917287
Adults with Attention Deficit Hyperactivity Disorder Report High Symptom Levels
of Troubled Sleep, Restless Legs, and Cataplexy.
Author information:
(1)Department of Global Public Health and Primary Care, University of
BergenBergen, Norway.
(2)Norwegian Competence Center for Sleep Disorders, Haukeland University
HospitalBergen, Norway.
(3)Division of Psychiatry, Haukeland University HospitalBergen, Norway.
(4)Department of Biomedicine, K.G. Jebsen Centre for Neuropsychiatric Disorders,
University of BergenBergen, Norway.
(5)Department of Biological and Medical Psychology, University of BergenBergen,
Norway.
DOI: 10.3389/fpsyg.2017.01621
PMCID: PMC5611698
PMID: 28979226
860. MMWR Morb Mortal Wkly Rep. 2018 Feb 23;67(7):219-224. doi:
10.15585/mmwr.mm6707a4.
Author information:
(1)Division for Heart Disease and Stroke Prevention, National Center for Chronic
Disease Prevention and Health Promotion, CDC.
Hypertension, which affects nearly one third of adults in the United States, is a
major risk factor for heart disease and stroke (1), and only approximately half
of those with hypertension have their hypertension under control (2). The
prevalence of hypertension is highest among non-Hispanic blacks, whereas the
prevalence of antihypertensive medication use is lowest among Hispanics (1).
Geographic variations have also been identified: a recent report indicated that
the Southern region of the United States had the highest prevalence of
hypertension as well as the highest prevalence of medication use (3). Using data
from the Behavioral Risk Factor Surveillance System (BRFSS), this study found
minimal change in state-level prevalence of hypertension awareness and treatment
among U.S. adults during the first half of the current decade. From 2011 to 2015,
the age-standardized prevalence of self-reported hypertension decreased slightly,
from 30.1% to 29.8% (p = 0.031); among those with hypertension, the
age-standardized prevalence of medication use also decreased slightly, from 63.0%
to 61.8% (p<0.001). Persistent differences were observed by age, sex,
race/ethnicity, level of education, and state of residence. Increasing
hypertension awareness, as well as increasing hypertension control through
lifestyle changes and consistent antihypertensive medication use, requires
diverse clinical and public health intervention.
DOI: 10.15585/mmwr.mm6707a4
PMCID: PMC5858041
PMID: 29470459 [Indexed for MEDLINE]
Author information:
(1)Health Equity and Rural Outreach Innovation Center (HEROIC), Charleston VA
HSR&D COIN, Ralph H. Johnson VAMC, Charleston, SC; Center for Health Disparities
Research, Medical University of South Carolina, Charleston, SC; Department of
Health Science and Research, Medical University of South Carolina, Charleston,
SC.
(2)Health Equity and Rural Outreach Innovation Center (HEROIC), Charleston VA
HSR&D COIN, Ralph H. Johnson VAMC, Charleston, SC; Division of Public Health
Sciences, Department of Medicine, Medical University of South Carolina,
Charleston, SC.
(3)Department of Health Science and Research, Medical University of South
Carolina, Charleston, SC; Department of Otolaryngology-Head and Neck Surgery,
Medical University of South Carolina, Charleston, SC.
(4)Health Equity and Rural Outreach Innovation Center (HEROIC), Charleston VA
HSR&D COIN, Ralph H. Johnson VAMC, Charleston, SC; Center for Health Disparities
Research, Medical University of South Carolina, Charleston, SC; Division of
General Internal Medicine and Geriatrics, Department of Medicine, Medical
University of South Carolina, Charleston, SC. Electronic address:
egedel@musc.edu.
OBJECTIVE: The purpose of this study was to investigate the independent effects
of socioeconomic and psychological social determinants of health on diabetes
knowledge, self-care, diabetes outcomes and quality of life.
RESEARCH DESIGN AND METHODS: Cross-sectional sample of 615 adults from two adult
primary care clinics in the southeastern United States. Primary outcome variables
were diabetes knowledge, self-care behaviors (diet, exercise, medication
adherence, blood sugar testing, foot care) and diabetes outcomes (HbA1c,
low-density lipoprotein, blood pressure, physical component summary score of SF12
quality of life, mental component summary score of SF12 quality of life).
Covariates included age, sex, race/ethnicity, marital status, health literacy and
comorbidity. Linear regression models were used to assess independent
associations controlling for covariates.
RESULTS: In final adjusted models, significant associations for HbA1c included
education [β = -0.72, 95% confidence interval (CI): -1.36 to -0.08], income (β =
-0.66, CI: -1.30 to -0.16), self-efficacy (β = -0.12, CI: -0.15 to -0.08) and
diabetes distress (β = 0.43, CI: 0.14 to 0.72). Significant associations for
self-care included medication adherence with diabetes distress (β = -0.58, CI:
-0.91 to -0.25) and perceived stress (β = -0.12, CI: -0.18 to -0.05) and exercise
with depression (β = -0.06, CI: -0.10 to -0.01) and self-efficacy (β = 0.06, CI:
0.01 to 0.10). Significant associations for quality of life included depression
(β = -0.08, CI: -0.12 to -0.03), serious psychological distress (β = -0.09, CI:
-0.12 to -0.05), social support (β = 0.01, CI: 0.001 to 0.02) and perceived
stress (β = -0.12, CI: -0.19 to -0.06).
CONCLUSIONS: Social determinants of health were significantly associated with
diabetes self-care and outcomes with socioeconomic factors being most often
associated with diabetes outcomes and psychological factors, specifically
self-efficacy and perceived stress being most often associated with self-care and
quality of life.
DOI: 10.1016/j.genhosppsych.2014.06.011
PMCID: PMC4254055
PMID: 25103544 [Indexed for MEDLINE]
Gomes ALA(1), Lima KF(1), Mendes ERDR(1), Joventino ES(2), Martins MC(1), Almeida
PC(3), Ximenes LB(1).
Author information:
(1)Universidade Federal do Ceará, Fortaleza, CE, Brazil.
(2)Universidade da Integração Internacional da Lusofonia Afro-Brasileira,
Redenção, CE, Brazil.
(3)Universidade Estadual do Ceará, Fortaleza, CE, Brazil.
DOI: 10.1590/s1980-220x2017008003282
PMID: 29562048 [Indexed for MEDLINE]
Suh YS(1), Cheon YH(1), Kim HO(1), Kim RB(2), Park KS(2), Kim SH(3), Lee SG(4),
Park EK(4), Hur J(5), Lee SI(1).
Author information:
(1)Department of Internal Medicine and Health Science Institute, Gyeongsang
National University Hospital, Jinju, Korea.
(2)Department of Preventive Medicine, Gyeongsang National University Hospital,
Jinju, Korea.
(3)Department of Internal Medicine, Keimyung University Dongsan Medical Center,
Daegu, Korea.
(4)Department of Internal Medicine, Pusan National University School of Medicine,
Busan, Korea.
(5)Department of Internal Medicine, Yeungnam University Medical Center, Daegu,
Korea.
Comment in
Korean J Intern Med. 2018 Nov;33(6):1252-1253.
Korean J Intern Med. 2018 Nov;33(6):1254.
DOI: 10.3904/kjim.2015.383
PMCID: PMC5768535
PMID: 28859470 [Indexed for MEDLINE]
Morrison CF(1), Martsolf DM(2), Wehrkamp N(2), Tehan R(2), Pai ALH(3).
Author information:
(1)Center for the Promotion of Adherence and Self-Management, Division of
Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital
Medical Center, Cincinnati, Ohio. Electronic address:
caroline.morrison@cchmc.org.
(2)College of Nursing, University of Cincinnati, Cincinnati, Ohio.
(3)Center for the Promotion of Adherence and Self-Management, Division of
Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital
Medical Center, Cincinnati, Ohio; Patient and Family Wellness Center, Cancer and
Blood Diseases Institute, Cincinnati Children's Hospital Medical Center,
Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati School of
Medicine, Cincinnati, Ohio.
Adherence to oral medications has been repeatedly shown to fall below the
recommended 80% to 95% in pediatric and adult cancer populations. The purpose of
this review is to report the state of the science about oral medication adherence
during the acute phase of hematopoietic stem cell transplantation across the
lifespan. An exhaustive search of the literature yielded 5 records for inclusion
in the review. Two studies examined adherence in pediatrics, 2 in adults, and 1
included both pediatric and adult patients. Three studies were descriptive and 2
were interventional in design. The rate of adherence to oral medications ranged
from 33% to 94.7%. Adherence decreased over time in all studies except in 1
pharmacist-led intervention study. Different methods were used to measure
adherence, but most relied on self-report. Further research is needed in
medication adherence in hematopoietic stem cell transplantation to better
understand facilitators, barriers, and relationships to health outcomes.
Copyright © 2017 The American Society for Blood and Marrow Transplantation.
Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.bbmt.2017.01.008
PMID: 28087458 [Indexed for MEDLINE]
Author information:
(1)Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia.
(2)Department of Endocrinology, St. Vincent Hospital, Sydney, NSW, Australia.
DOI: 10.1371/journal.pone.0118296
PMCID: PMC4339210
PMID: 25710465 [Indexed for MEDLINE]
Author information:
(1)Center for Health Organization and Implementation Research (CHOIR), eHealth
Quality Enhancement Research Initiative (QUERI), Edith Nourse Rogers Memorial
Veterans Hospital, Bedford, MA, United States.
(2)Department of Health Sciences and Research, College of Health Professions,
Medical University of South Carolina, Charleston, SC, United States.
(3)Department of Healthcare Leadership and Management, College of Health
Professions, Medical University of South Carolina, Charleston, SC, United States.
(4)Center for Health Disparities Research, Medical University of South Carolina,
Charleston, SC, United States; Division of General Internal Medicine and
Geriatrics, Department of Medicien, Medical University of South Carolina,
Charleston, SC, United States; Health Equity and Rural Research Innovation Center
(HEROIC), Charleston VA HSR&D COIN, Charleston, SC, United States. Electronic
address: egedel@musc.edu.
OBJECTIVE: The objective of this study was to identify latent variables for
neighborhood factors and diabetes self-care and examine the effect of
neighborhood factors on diabetes self-care in adults with type 2 diabetes.
RESEARCH DESIGN AND METHODS: 615 subjects were recruited from an academic medical
center and a Veterans affairs medical center in the southeastern United States.
Validated scales were used to assess neighborhood factors and diabetes-related
self-care. Confirmatory factor analysis (CFA) was used to determine the latent
constructs. Structural equation modeling (SEM) was then used to assess the
relationship between neighborhood factors and diabetes self-care.
RESULTS: Based on a theoretical framework, CFA yielded four latent variables for
neighborhood factors (neighborhood violence, access to healthy food, social
support, and neighborhood esthetics) and one latent variable diabetes self-care
(including diet, exercise, foot care, blood sugar testing and medication
adherence). SEM showed that social support (r=0.28, p<0.001) and access to
healthy foods (r=-0.16, p=0.003) were significantly associated with self-care
behaviors, while neighborhood violence (r=-0.06, p<0.001) and esthetics (r=-0.07,
p=0.278) were not χ(2) (180, N=611)=192, p=0.26, RMSEA=0.01, CFI=0.999). In the
final trimmed model, social support (r=0.31, p<0.001) and access to healthy foods
(r=-0.20, p<0.001) remained significantly associated with self-care behaviors
χ(2) (76, N=611)=60, p=0.91, RMSEA=0.00, CFI=1.0).
CONCLUSION: This study developed latent factors for neighborhood characteristics
and diabetes self-care and found that social support and access to healthy foods
were significantly associated with diabetes self-care and should be considered as
targets for future interventions.
DOI: 10.1016/j.diabres.2014.09.029
PMCID: PMC4275065
PMID: 25451904 [Indexed for MEDLINE]
Drug holidays: the most frequent type of noncompliance with calcium plus vitamin
D supplementation in persistent patients with osteoporosis.
Touskova T(1), Vytrisalova M(1), Palicka V(2), Hendrychova T(1), Fuksa L(1),
Holcova R(1), Konopacova J(1), Kubena AA(1).
Author information:
(1)Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec
Kralove, Charles University in Prague, Hradec Kralove, Czech Republic.
(2)Osteocentre, Institute of Clinical Biochemistry and Diagnostics, Charles
University in Prague, Faculty of Medicine and University Hospital in Hradec
Kralove, Hradec Kralove, Czech Republic.
DOI: 10.2147/PPA.S88630
PMCID: PMC4689262
PMID: 26719680
Author information:
(1)Dilchora Hospital, Diredawa, East Ethiopia.
(2)Department of Epidemiology, College of Health Sciences, Jimma University,
Jimma, Ethiopia. hailushepi@gmail.com.
(3)Discipline of Public Health, Faculty of Medicine, Nursing and Health Sciences,
Flinders University, Adelaide, Australia. hailushepi@gmail.com.
(4)Discipline of Public Health, Faculty of Medicine, Nursing and Health Sciences,
Flinders University, Adelaide, Australia.
(5)Department of Clinical Pharmacy, College of Health Sciences, Jimma University,
Jimma, Ethiopia.
DOI: 10.1186/s12902-016-0114-x
PMCID: PMC4933997
PMID: 27381349 [Indexed for MEDLINE]
Hu Y(1), Zhong XN(2), Peng B(1), Zhang Y(1), Liang H(3), Dai JH(4), Zhang JY(5),
Huang AL(6).
Author information:
(1)Department of Health Statistics and Information Management, School of Public
Health and Management, Chongqing Medical University, Chongqing, China.
(2)Department of Health Statistics and Information Management, School of Public
Health and Management, Chongqing Medical University, Chongqing, China.
zxn133cq@sina.com.
(3)Department of Epidemiology and Medical Statistics, School of Public Health,
Guangxi Medical University, Nanning, China.
(4)Department of Epidemiology and Health Statistics, School of Public Health,
Xinjiang Medical University, Xinjiang, China.
(5)Department of Epidemiology and Medical Statistics, School of Public Health,
Sichuan University, Sichuan, China.
(6)Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of
Education, Chongqing Medical University, Chongqing, China.
DOI: 10.1186/s12879-018-3497-7
PMCID: PMC6238290
PMID: 30442106 [Indexed for MEDLINE]
Kuria N(1), Reid A(2), Owiti P(3)(4), Tweya H(5), Kibet CK(6), Mbau L(1), Manzi
M(2), Murunga V(1), Namusonge T(1), Kibachio J(7)(8).
Author information:
(1)Amref Health Africa in Kenya, Nairobi, Kenya.
(2)Operational Research Unit, Operational Centre Brussels, Medécins Sans
Frontières, Luxembourg, Luxembourg.
(3)Academic Model Providing Access to Healthcare, Eldoret, Kenya.
(4)International Union against Tuberculosis and Lung Disease, Paris, France.
(5)Lighthouse Trust, Lilongwe, Malawi.
(6)Computer Science Department, Rhodes University, Rhodes, South Africa.
(7)Division of Noncommunicable Diseases, Ministry of Health, Nairobi, Kenya.
(8)The National Public Health Institute, Nairobi, Kenya.
OBJECTIVE: To determine and compare, among three models of care, compliance with
scheduled clinic appointments and adherence to antihypertensive medication of
patients in an informal settlement of Kibera, Kenya.
METHODS: Routinely collected patient data were used from three health facilities,
six walkway clinics and one weekend/church clinic. Patients were eligible if they
had received hypertension care for more than 6 months. Compliance with clinic
appointments and self-reported adherence to medication were determined from
clinic records and compared using the chi-square test. Univariate and
multivariate logistic regression models estimated the odds of overall adherence
to medication.
RESULTS: A total of 785 patients received hypertension treatment eligible for
analysis, of whom two-thirds were women. Between them, there were 5879 clinic
visits with an overall compliance with appointments of 63%. Compliance was high
in the health facilities and walkway clinics, but men were more likely to attend
the weekend/church clinics. Self-reported adherence to medication by those
complying with scheduled clinic visits was 94%. Patients in the walkway clinics
were two times more likely to adhere to antihypertensive medication than patients
at the health facility (OR 1.97, 95% CI 1.25-3.10).
CONCLUSION: Walkway clinics outperformed health facilities and weekend clinics.
The use of multiple sites for the management of hypertensive patients led to good
compliance with scheduled clinic visits and very good self-reported adherence to
medication in a low-resource setting.
© 2018 The Authors. Tropical Medicine & International Health Published by John
Wiley & Sons Ltd.
DOI: 10.1111/tmi.13078
PMID: 29779264 [Indexed for MEDLINE]
871. Res Social Adm Pharm. 2019 Aug 13. pii: S1551-7411(19)30192-5. doi:
10.1016/j.sapharm.2019.08.004. [Epub ahead of print]
How are medication related problems managed in primary care? An exploratory study
in patients with diabetes and primary care providers.
van Eikenhorst L(1), Taxis K(2), Rademakers J(3), Zullig LL(4), de Gier H(5), van
Dijk L(6).
Author information:
(1)University of Groningen, Groningen Research Institute of Pharmacy,
PharmacoTherapy, -Epidemiology & -Economics, P.O. Box 196, 9700 AD, Groningen,
the Netherlands. Electronic address: l.van.eikenhorst@rug.nl.
(2)University of Groningen, Groningen Research Institute of Pharmacy,
PharmacoTherapy, -Epidemiology & -Economics, P.O. Box 196, 9700 AD, Groningen,
the Netherlands. Electronic address: k.taxis@rug.nl.
(3)Nivel, Netherlands Institute for Health Services Research, Otterstraat 118,
3513 CR, Utrecht, the Netherlands; Department of Family Medicine, Care and Public
Health Research Institute (CAPHRI), Maastricht University, 6200 MD, Maastricht,
the Netherlands. Electronic address: j.rademakers@nivel.nl.
(4)Department of Population Health Sciences, Duke University, 215 Morris Street,
Durham, NC, 27701, USA; Center to Accelerate Discovery and Practice
Transformation (ADAPT), Durham Veterans Affairs Health Care System, 411 West
Chapel Hill Street, Suite 600, Durham, NC, 27701, USA. Electronic address:
leah.zullig@duke.edu.
(5)University of Groningen, Groningen Research Institute of Pharmacy,
PharmacoTherapy, -Epidemiology & -Economics, P.O. Box 196, 9700 AD, Groningen,
the Netherlands. Electronic address: degiercs@wxs.nl.
(6)University of Groningen, Groningen Research Institute of Pharmacy,
PharmacoTherapy, -Epidemiology & -Economics, P.O. Box 196, 9700 AD, Groningen,
the Netherlands; Nivel, Netherlands Institute for Health Services Research,
Otterstraat 118, 3513 CR, Utrecht, the Netherlands. Electronic address:
l.vandijk@nivel.nl.
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.sapharm.2019.08.004
PMID: 31427177
Snyder ME(1), Pater KS(2), Frail CK(3), Hudmon KS(4), Doebbeling BN(5), Smith
RB(2).
Author information:
(1)Purdue University College of Pharmacy, 640 Eskenazi Ave., Indianapolis, IN
46202, USA. Electronic address: snyderme@purdue.edu.
(2)University of Pittsburgh School of Pharmacy, 3501 Terrace St., Pittsburgh, PA
15261, USA.
(3)University of Minnesota College of Pharmacy, 7-174 Weaver-Densford Hall, 308
Harvard St., SE, Minneapolis, MN 55455, USA.
(4)Purdue University College of Pharmacy, 640 Eskenazi Ave., Indianapolis, IN
46202, USA.
(5)Department of Biohealth Informatics, Indiana University and Purdue University
Indianapolis, School of Informatics & Computing, 719 Indiana Ave, WK 303,
Indianapolis, IN 46202, USA.
DOI: 10.1016/j.sapharm.2014.08.005
PMCID: PMC4329268
PMID: 25443640 [Indexed for MEDLINE]
Wykes T(1), Evans J(2), Paton C(3), Barnes TRE(4), Taylor D(5), Bentall R(6),
Dalton B(7), Ruffell T(8), Rose D(8), Vitoratou S(8).
Author information:
(1)Psychology Department,Institute of Psychiatry, Psychology, and Neuroscience,
King's College London,London,UK.
(2)NIHR Biomedical Research Centre, South London and Maudsley NHS Foundation
Trust and Institute of Psychiatry, Psychology, and Neuroscience, King's College
London,London,UK.
(3)Chief Pharmacist,Oxleas NHS Foundation Trust,Dartford,UK.
(4)Centre for Psychiatry, Imperial College London,London,UK.
(5)Pharmacy and Pathology,South London and Maudsley NHS Foundation
Trust,London,UK.
(6)Department of Psychological Sciences,University of Liverpool,UK.
(7)Department for Psychological Medicine,Institute of Psychiatry, Psychology, and
Neuroscience, King's College London,London,UK.
(8)Health Service & Population Research,Centre for Implementation
Science,Institute of Psychiatry, Psychology, and Neuroscience, King's College
London,London,UK.
DOI: 10.1017/S0033291717000903
PMCID: PMC5820531
PMID: 28420450 [Indexed for MEDLINE]
874. Nicotine Tob Res. 2016 May;18(5):1202-5. doi: 10.1093/ntr/ntv179. Epub 2015
Nov
13.
Leischow SJ(1), Muramoto ML(2), Matthews E(2), Floden LL(2), Grana RA(3).
Author information:
(1)Department of Research, Mayo Clinic Arizona, Scottsdale, AZ;
leischow.scott@mayo.edu.
(2)Department of Family and Community Medicine, University of Arizona, Tucson,
AZ;
(3)Tobacco Control Research Branch, National Cancer Institute, Bethesda, MD.
© The Author 2015. Published by Oxford University Press on behalf of the Society
for Research on Nicotine and Tobacco. All rights reserved. For permissions,
please e-mail: journals.permissions@oup.com.
DOI: 10.1093/ntr/ntv179
PMCID: PMC5896821
PMID: 26567274 [Indexed for MEDLINE]
Granger BB(1), Ekman I(2), Hernandez AF(3), Sawyer T(4), Bowers MT(5), DeWald
TA(4), Zhao Y(6), Levy J(7), Bosworth HB(8).
Author information:
(1)Duke University School of Nursing, Durham, NC; Duke University Health Systems,
Durham, NC. Electronic address: bradi.granger@dm.duke.edu.
(2)Institute of Health and Care Sciences, Centre for Person-Centred Care,
University of Gothenburg, Göteborg, Sweden.
(3)Duke Clinical Research Institute, Duke Medicine, Durham, NC.
(4)Duke University Health Systems, Durham, NC.
(5)Duke University School of Nursing, Durham, NC; Duke University Health Systems,
Durham, NC.
(6)SAS Institute, Cary, NC.
(7)Duke University School of Nursing, Durham, NC.
(8)Center for Health Services Research in Primary Care, VA Medical Center,
Durham, NC.
DOI: 10.1016/j.ahj.2015.01.006
PMCID: PMC5058442
PMID: 25819861 [Indexed for MEDLINE]
Author information:
(1)Health Outcomes and Pharmacy Practice Division, The University of Texas at
Austin College of Pharmacy, Austin, Texas, United States.
(2)Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy,
University of Lagos, Lagos, Nigeria.
BACKGROUND: Through several initiatives, there are increasingly more people who
have access to anti-retroviral therapy. Adherence to therapy is, however,
necessary for successful management of disease.
OBJECTIVES: The objectives of this study were to describe adherence rates and
determine what patient-related factors are related to adherence to
anti-retroviral therapy among adult patients in an HIV clinic located in Lagos,
Nigeria.
METHODS: Adherence was measured using the two-week self-recall method. Barriers,
satisfaction with therapy, and socio-demographic and clinical variables served as
independent variables. Data were collected via self-administered surveys.
RESULTS: Most of the patients (79.5%) reported 100% adherence. The significant
(p<0.05) barriers to adherence were forgetfulness, running out of medication,
alcohol use, and medication side effects. For every unit increase in the number
of barriers, patients were 60.8% less likely to be 100% adherent (p <0.05, odds
ratio, OR = 0.392, 95% CI = 0.295-0.523).
CONCLUSION: Interventions should target helping patients cope with forgetfulness,
specifically employing strategies to overcome busyness in schedules, being away
from home, and tiredness.
DOI: 10.4314/ahs.v17i3.16
PMCID: PMC5656197
PMID: 29085401 [Indexed for MEDLINE]
Author information:
(1)Addis Continental Institute of Public Health, Addis Ababa, Ethiopia.
DOI: 10.1371/journal.pone.0169062
PMCID: PMC5207399
PMID: 28045992 [Indexed for MEDLINE]
Knowledge of Inhaled Therapy and Responsibility for Asthma Management Among Young
Teens With Uncontrolled Persistent Asthma.
Frey SM(1), Jones MR(2), Goldstein N(2), Riekert K(3), Fagnano M(2), Halterman
JS(2).
Author information:
(1)University of Rochester School of Medicine and Dentistry, Rochester, NY.
Electronic address: Sean_Frey@urmc.rochester.edu.
(2)University of Rochester School of Medicine and Dentistry, Rochester, NY.
(3)Johns Hopkins School of Medicine, Baltimore, Md.
DOI: 10.1016/j.acap.2018.01.006
PMCID: PMC5903444
PMID: 29369804 [Indexed for MEDLINE]
879. AMIA Annu Symp Proc. 2014 Nov 14;2014:1728-37. eCollection 2014.
Author information:
(1)School of Information, University of Michigan, Ann Arbor, MI.
(2)School of Information, University of Michigan, Ann Arbor, MI ; School of
Public Health, University of Michigan, Ann Arbor, MI.
For those with high blood pressure, diabetes, or high cholesterol, adherence to a
home medication regimen is important for health. Reductions in the number of
daily medication-taking events or daily pill burden improve adherence. A novel
advice-giving computer application was developed using the SMART platform to
generate advice on how to potentially simplify home medication regimens.
MedMinify generated advice for 41.3% of 1,500 home medication regimens for adults
age 60 years and older with chronic medical conditions. If the advice given by
MedMinify were implemented, 320 regimen changes would have reduced daily
medication-taking events while an additional 295 changes would have decreased the
daily pill burden. The application identified four serious drug-drug interactions
and so advised against taking two pairs of medications simultaneously. MedMinify
can give advice to change home medication regimens that could result in simpler
home medication-taking schedules.
PMCID: PMC4420013
PMID: 25954445 [Indexed for MEDLINE]
Ong SW(1), Jassal SV(2), Miller JA(3), Porter EC(4), Cafazzo JA(5), Seto E(6),
Thorpe KE(7), Logan AG(8).
Author information:
(1)Departments of Pharmacy, Nephrology.
(2)Medicine, Nephrology, Institute of Health Policy, Management and Evaluation,
Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;
(3)Medicine, Nephrology, Faculty of Medicine, University of Toronto, Toronto,
Ontario, Canada;
(4)Nursing, and Nephrology.
(5)Lunenfeld-Tanenbaum Research Institute and Department of Medicine, Mount Sinai
Hospital, Toronto, Ontario, Canada; Techna Institute, University Health Network,
Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation,
Institute of Biomaterials and Biomedical Engineering.
(6)Institute of Health Policy, Management and Evaluation, Centre for Global
eHealth Innovation, and Techna Institute, University Health Network, Toronto,
Ontario, Canada;
(7)Dalla Lana School of Public Health, University of Toronto, and Applied Health
Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital,
Toronto, Ontario, Canada.
(8)Medicine, Nephrology, Lunenfeld-Tanenbaum Research Institute and Department of
Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada; Faculty of Medicine,
University of Toronto, Toronto, Ontario, Canada; logan@lunenfeld.ca.
Comment in
Clin J Am Soc Nephrol. 2016 Jun 6;11(6):935-7.
DOI: 10.2215/CJN.10681015
PMCID: PMC4891756
PMID: 27173169 [Indexed for MEDLINE]
Author information:
(1)University of Missouri School of Nursing, Columbia, MO, USA conn@missouri.edu.
(2)University of Missouri School of Nursing, Columbia, MO, USA.
DOI: 10.5993/AJHB.40.2.1
PMCID: PMC4879970 [Available on 2017-03-01]
PMID: 26931748 [Indexed for MEDLINE]
Author information:
(1)Drug Safety Center and Dept. of Clinical Pharmacy, Leipzig University,
Brüderstraße 22, 04103 Leipzig, Germany.
(2)University Hospital for Children and Adolescents, Centre of Paediatric
Research, Liebigstraße 20a, 04103, Leipzig, Germany.
(3)University Hospital for Children and Adolescents, Centre of Paediatric
Research, Liebigstraße 20a, 04103, Leipzig, Germany. Electronic address:
Astrid.Bertsche@medizin.uni-leipzig.de.
PURPOSE: Prolonged seizures can cause severe harm and even death. For seizures
lasting longer than 5min, an administration of rescue medication is therefore
recommended. Caregivers such as preschool teachers should be able to administer
correctly anticonvulsive rescue medication to children.
METHODS: A training concept for preschool teachers on seizure management
focussing on practical skills was developed. To assess the success of the
training, a structured interview on attitudes relating to rescue medication
administration was conducted. The number of committed errors during
administration of a rectal/buccal rescue medication to dummy dolls was compared
before and after training.
RESULTS: 210 teachers from 115 preschools participated while all teachers from
303 preschools had been invited. The self-reported level of confidence in their
own skills to administer anticonvulsive rescue medication increased from 5 to 8
on a scale from 1 to 10 (p<0.001). The number of participants who agreed to
administer rescue medication rose from 195/210 (92.8%) before training to 209/210
(99.5%, p<0.001) after training for the rectal route, and from 173/210 (82.4%) to
209/210 (99.5%, p<0.001) for the buccal route. For teachers who administered
rescue medication before and after training, the number of administrations
without any administration errors rose from 1/195 (0.5%) to 117/195 (60.0%,
p<0.001) for the rectal route, and from 13/173 (7.5%) to 95/173 (54.9%, p<0.001)
for the buccal route.
CONCLUSION: A training for preschool teachers boosted the level of
self-confidence relating to administration of anticonvulsive rescue medication.
Teachers also committed fewer errors when administering rescue medication to
dummy dolls.
DOI: 10.1016/j.seizure.2017.06.001
PMID: 28605661 [Indexed for MEDLINE]
Kosilov KV(1)(2), Loparev SA(3), Kuzina IG(4), Shakirova OV(5), Gainullina YI(1),
Kosilova LV(6), Prokofyeva AS(7).
Author information:
(1)Department of Social Sciences, School of Humanities, Far Eastern Federal
University, Vladivostok, Primorsky Region, Russian Federation.
(2)Department of Public Helth, Pacific Medical State University, Vladivostok,
Russian Federation.
(3)Department of Urology, City Polyclinic № 3, Vladivostok, Russian Federation.
(4)Department of Social Science, Far Eastern Federal University, Vladivostok,
Primorsky Region, Russian Federation.
(5)Department of Theory and Methods of Adaptive Physical Education, Far Eastern
Federal University, Vladivostok, Primorsky Region, Russian Federation.
(6)Department of Functional Methods of Examination, Med. Association № 2 of
Vladivostok City, Vladivostok, Russian Federation.
(7)Department Social Science, Far Eastern Federal University, Vladivostok,
Primorsky Region, Russian Federation.
DOI: 10.1016/j.aju.2017.10.007
PMCID: PMC5717450
PMID: 29234543
884. Alcohol Clin Exp Res. 2016 Jul;40(7):1425-9. doi: 10.1111/acer.13095. Epub
2016
May 24.
Arout CA(1), Perrino AC Jr(2), Ralevski E(1), Acampora G(3), Koretski J(1),
Limoncelli D(1), Newcomb J(1), Petrakis IL(1).
Author information:
(1)Department of Psychiatry, Center for Translational Neuroscience of Alcoholism
and VA Alcohol Research Center, Yale University School of Medicine, West Haven,
Connecticut.
(2)Department of Anesthesiology, VA Connecticut Healthcare System, Yale
University School of Medicine, West Haven, Connecticut.
(3)Department of Psychiatry, Massachusetts General Hospital, Harvard Center for
Addiction Medicine, Boston, Massachusetts.
BACKGROUND: The objective of this study was to assess ethanol's (EtOH's) effects
on capsaicin-induced hyperalgesia in healthy participants. Specifically, we
investigated the change in area of capsaicin-induced hyperalgesia following 3
interventions: intravenous EtOH at 2 targeted breath alcohol concentrations
(BrAC), or placebo.
METHODS: Eighteen participants participated in 3 test days in a randomized order.
Each test day, participants received an intradermal capsaicin injection on the
volar surface of the forearm, followed by either infusion of high concentration
EtOH (targeted BrAC = 0.100 g/dl), low concentration EtOH (targeted
BrAC = 0.040 g/dl), or placebo. The area of hyperalgesia was determined by von
Frey technique at 2 time points, prior to EtOH infusion, and again when target
BrAC was reached. The primary outcome was the percent change in the area of
capsaicin-induced hyperalgesia. Additional outcome measures included the visual
analogue scale of mood states (VAS), which was administered at each time point.
RESULTS: There was a marked 30% reduction in the area of capsaicin-induced
hyperalgesia with infusion of a high concentration of EtOH (p < 0.05). Low
concentration EtOH produced a 10% reduction in hyperalgesia area, although this
finding did not reach significance. Further, participants reported significant
feelings of euphoria and drowsiness at high concentrations of EtOH (p < 0.05), as
measured by the VAS.
CONCLUSIONS: In a human model examining pain phenomena related to central
sensitization, this study is the first to demonstrate that capsaicin-induced
hyperalgesia is markedly attenuated by EtOH. The capsaicin experimental pain
paradigm employed provides a novel approach to evaluate EtOH's effects on pain
processing. The antihyperalgesic effects of EtOH observed have important clinical
implications for the converging fields of substance abuse and pain medicine and
may inform why patients with chronic pain often report alcohol use as a form of
self-medication.
DOI: 10.1111/acer.13095
PMCID: PMC4930397
PMID: 27218476 [Indexed for MEDLINE]
Author information:
(1)Department of Physical Medicine and Rehabilitation, University of Michigan,
Ann Arbor, MI.
DOI: 10.1097/AJP.0000000000000550
PMCID: PMC5835158
PMID: 28877136 [Indexed for MEDLINE]
Burnett DM(1), Vardiman JP(2), Deckert JA(2), Ward JL(2), Sharpe MR(3).
Author information:
(1)University of Kansas Medical Center, Kansas City, Kansas. dburnett@kumc.edu.
(2)University of Kansas, Lawrence, Kansas.
(3)University of Kansas Medical Center, Kansas City, Kansas.
Comment in
Respir Care. 2016 Jul;61(7):994-5.
Luedke MW, Blalock DV, Lewinski AA, Shapiro A, Drake C, Lewis JD, Goldstein KM,
Husain AM, Gierisch JM, Sinha SR, Tran TT, Gordon AM, Kosinski AS, Bosworth HB,
Van Noord M, Williams, Jr. JW.
Washington (DC): Department of Veterans Affairs (US); 2019.
VA Evidence-based Synthesis Program Reports.
PMID: 31361424
Author information:
(1)Social Determinants of Health research center, Isfahan University of Medical
Sciences, Isfahan, Iran.
(2)Health Information Technology Research Center, Isfahan University of Medical
Sciences, Isfahan, Iran.
(3)Department of Health Information Technology and Management, School of
Management and Medical Information Sciences, Isfahan University of Medical
Sciences, Isfahan, Iran.
DOI: 10.5455/aim.2017.25.108-111
PMCID: PMC5544449
PMID: 28883675
Author information:
(1)Ferkauf Graduate School of Psychology.
(2)Department of Pediatrics, Stanford University School of Medicine.
(3)Joslin Diabetes Center.
DOI: 10.1037/a0040388
PMCID: PMC5792162
PMID: 27690483 [Indexed for MEDLINE]
Author information:
(1)The University of Michigan, Ann Arbor, Michigan, United States of America.
(2)Instituto Nacional de Salud, Lima, Perú.
(3)Innovación Por la Salud Y Desarrollo (IPSYD), Asociación Benéfica PRISMA,
Lima, Perú.
(4)Innovation for Health and Development (IFHAD), Laboratory of Research and
Development, Universidad Peruana Cayetano Heredia, Lima, Perú.
(5)Infectious Diseases & Immunity, Imperial College London, and Wellcome Trust
Imperial College Centre for Global Health Research, London, United Kingdom.
(6)Department of Health Policy and Management, University of North Carolina
Gillings School of Global Public Health, Chapel Hill, North Carolina, United
States of America.
DOI: 10.1371/journal.pone.0185018
PMCID: PMC5612650
PMID: 28945782 [Indexed for MEDLINE]
Current knowledge, attitude and behaviour of hand and food hygiene in a developed
residential community of Singapore: a cross-sectional survey.
Author information:
(1)Centre for Infectious Disease Epidemiology and Research, Saw Swee Hock School
of Public Health, National University of Singapore, Singapore, Singapore.
Junxiong_Pang@nuhs.edu.sg.
(2)Centre for Infectious Disease Epidemiology and Research, Saw Swee Hock School
of Public Health, National University of Singapore, Singapore, Singapore.
jonathan_lumen@nuhs.edu.sg.
(3)Centre for Infectious Disease Epidemiology and Research, Saw Swee Hock School
of Public Health, National University of Singapore, Singapore, Singapore.
hsuliyang@gmail.com.
(4)Department of Medicine, Yong Loo Lin School of Medicine, National University
of Singapore, Singapore, Singapore. hsuliyang@gmail.com.
BACKGROUND: Diarrhoea incidence has been increasing progressively over the past
years in developed countries, including Singapore, despite the accessibility and
availability to clean water, well-established sanitation infrastructures and
regular hygiene promotion. The aim of this study is to determine the current
knowledge, attitude and behaviour of hand and food hygiene, and the potential
risk factors of diarrhoea in a residential community of Singapore.
METHODS: A cross-sectional study was conducted within a residential area in the
west of Singapore from June to August 2013. A total of 1,156 household units were
randomly sampled and invited to participate in an interviewer-assisted survey
using standardised questionnaires. Descriptive, univariate and multivariate
analyses were performed using descriptive statistics, Fisher's Exact test and
multivariate logistic regression modelling, respectively. R program was used for
all statistical analysis. All tests were conducted at 5% level of significance
with 95% confidence intervals (CI) reported where applicable.
RESULTS: A total of 240 units (20.8%) consented and responded to the survey
invitation. About 77% of the expected knowledge and attitude were observed in at
least 80% of the participants, compared to only about 31% of the expected
behaviours and practises. Being single [adjusted odds ratio (AOR) = 2.29; 95%
CI = 1.16-4.48], having flu in the past six month (AOR = 3.24; 95%
CI = 1.74-6.06), preferred self-medication (AOR = 2.07; 95% CI = 1.06-4.12) were
risk factors of diarrhoea. Washing hands with water before attending to children
or sick persons (AOR = 0.30; 95% CI = 0.11-0.82), washing hands with water
(AOR = 0.16; 95% CI = 0.05-0.45) and water with soap (AOR = 0.29; 95%
CI = 0.12-0.72) after attending to children or sick persons, and hand washing
between 30 s to a minute (AOR = 0.44; 95% CI = 0.20-0.90) were protective factors
against diarrhoea.
CONCLUSIONS: Good knowledge and attitude of the participants did not positively
translate into high compliance and motivation to perform good hygiene practices.
This observation may have resulted in a significant extent on the increasing
diarrhoea incidences. Current interventions may be improved with more active
community partnership among the residents, schools and the relevant social
organizations, to raise awareness on the importance of compliance to good hygiene
practices, and the risk factors of diarrhoea. A large case-control study would be
required to validate these findings in future.
DOI: 10.1186/s12889-015-1910-3
PMCID: PMC4475322
PMID: 26093582 [Indexed for MEDLINE]
Author information:
(1)Department of Medical Laboratory Science, College of Medicine and Health
Sciences, Wollo University, P.O. Box 1145, Dessie, Ethiopia.
nebat_abdurae2003@yahoo.com.
(2)Department of Medical Laboratory Science, College of Medicine and Health
Sciences, Wollo University, P.O. Box 1145, Dessie, Ethiopia.
DOI: 10.1186/s12889-018-5823-9
PMCID: PMC6064094
PMID: 30055593
Khowaja AR(1), Mitton C(2), Qureshi R(3), Bryan S(4), Magee LA(5), von Dadelszen
P(5), Bhutta ZA(6).
Author information:
(1)Department of Obstetrics and Gynaecology,and British Columbia Children's
Hospital,University of British Columbia,Centre for Clinical Epidemiology and
Evaluation,Vancouver Coastal Health Research Institute,Division of Women & Child
Health,Aga Khan University.
(2)Centre for Clinical Epidemiology and Evaluation,Vancouver Coastal Health
Research Institute,School of Population and Public Health,University of British
Columbia,craig.mitton@ubc.ca.
(3)Division of Women & Child Health,Aga Khan University.
(4)Centre for Clinical Epidemiology and Evaluation,Vancouver Coastal Health
Research Institute,School of Population and Public Health,University of British
Columbia.
(5)Molecular and Clinical Sciences Research Institute,St George's,University of
London,Department of Obstetrics and Gynaecology,St George's University Hospitals
NHS Foundation Trust.
(6)Division of Women & Child Health,Aga Khan University,Program for Global
Pediatric Research,Hospital For Sick Children,Toronto.
DOI: 10.1017/S0266462317000320
PMCID: PMC5934709
PMID: 28587686 [Indexed for MEDLINE]
Gage SH(1)(2), Jones HJ(1)(3), Taylor AE(1)(2), Burgess S(1)(4), Zammit S(3)(5),
Munafò MR(1)(2).
Author information:
(1)MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol,
UK.
(2)UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology,
University of Bristol, Bristol, UK.
(3)School of Social and Community Medicine, University of Bristol, Bristol, UK.
(4)Department of Public Health and Primary Care, University of Cambridge,
Cambridge, UK.
(5)MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University,
Cardiff, UK.
DOI: 10.1038/srep40653
PMCID: PMC5244403
PMID: 28102331 [Indexed for MEDLINE]
Crabbe JC(1), Schlumbohm JP(2), Hack W(2), Barkley-Levenson AM(2), Metten P(2),
Lattal KM(3).
Author information:
(1)Portland Alcohol Research Center, VA Portland Health Care System, Portland, OR
97239, USA; Department of Behavioral Neuroscience, Oregon Health & Science
University, Portland, OR 97239, USA. Electronic address: crabbe@ohsu.edu.
(2)Portland Alcohol Research Center, VA Portland Health Care System, Portland, OR
97239, USA; Department of Behavioral Neuroscience, Oregon Health & Science
University, Portland, OR 97239, USA.
(3)Department of Behavioral Neuroscience, Oregon Health & Science University,
Portland, OR 97239, USA.
DOI: 10.1016/j.alcohol.2016.01.004
PMCID: PMC4855306
PMID: 27139234 [Indexed for MEDLINE]
896. J Adv Nurs. 2015 Dec;71(12):2965-76. doi: 10.1111/jan.12714. Epub 2015 Jun 23.
Spoelstra SL(1), Given CW(2), Sikorskii A(3), Coursaris CK(4), Majumder A(3),
DeKoekkoek T(1), Schueller M(1), Given BA(1).
Author information:
(1)College of Nursing, Michigan State University, East Lansing, Michigan, USA.
(2)Institute for Health Care Studies, Michigan State University, East Lansing,
Michigan, USA.
(3)Department of Statistics and Probability, Michigan State University, East
Lansing, Michigan, USA.
(4)Department of Telecommunication, Information Studies (Dr. Coursaris), Michigan
State University, East Lansing, Michigan, USA.
AIM: The aim of this study was to report a study protocol that examines
feasibility, preliminary efficacy and satisfaction of a text message intervention
on the outcome of medication adherence in adult patients prescribed oral
anti-cancer agents.
BACKGROUND: Administration of oral anti-cancer agents occurs in the home setting,
requiring patients to self-manage the regimen as prescribed. However, many
barriers to medication adherence exist: regimens are often complex, with cycling
of two or more medications; side effects of treatment; most cancer patients are
older with comorbid conditions and competing demands; and cognitive decline and
forgetfulness may occur. Research indicates patients miss nearly one-third of the
prescribed oral anti-cancer agent dosages. Text message interventions have been
shown to improve medication adherence in chronic conditions other than cancer.
However, a majority of those patients were less than 50 years of age and most
cancer patients are diagnosed later in life.
DESIGN: A two-group randomized controlled trial with repeated measures.
METHODS: Seventy-five adult patients newly prescribed an oral anti-cancer agent
will be recruited (project funded in April 2013) from community cancer centres
and a specialty pharmacy. Participants will be randomized to either a control
group (n = 25; usual care) or an intervention group (n = 50; usual care plus text
messages timed to medication regimen). Outcome measures include: medication
adherence, feasibility and satisfaction with the intervention. Data will be
collected over 8 weeks: baseline, weekly and exit.
DISCUSSION: Standardized text message intervention protocol and detailed study
procedures have been developed in this study to improve medication adherence.
DOI: 10.1111/jan.12714
PMCID: PMC4689681
PMID: 26100719 [Indexed for MEDLINE]
897. BMJ Open Diabetes Res Care. 2016 Jun 29;4(1):e000182. doi:
10.1136/bmjdrc-2015-000182. eCollection 2016.
Kelly K(1), Grau-Sepulveda MV(2), Goldstein BA(2), Spratt SE(3), Wolfley A(2),
Hatfield V(4), Murphy M(5), Jones E(6), Granger BB(7).
Author information:
(1)Department of Advanced Clinical Practice , Duke University Health System ,
Durham, North Carolina , USA.
(2)Duke Clinical Research Institute , Durham, North Carolina , USA.
(3)Department of Medicine , Duke University School of Medicine , Durham, North
Carolina , USA.
(4)Williamson Memorial Hospital Diabetes Management Clinic , Williamson, West
Virginia , USA.
(5)Department of Community Health , Cabarrus Health Alliance , Kannapolis, North
Carolina , USA.
(6)University of Mississippi Medical Center, School of Health Related Professions
, Jackson, Mississippi , USA.
(7)Duke University Health System, School of Nursing , Durham, North Carolina ,
USA.
DOI: 10.1136/bmjdrc-2015-000182
PMCID: PMC4932248
PMID: 27403322
Author information:
(1)University of Florida College of Pharmacy, Gainesville, Florida.
(2)University of Florida Colleges of Dentistry & Education, Gainesville, Florida.
(3)Amplify, Brooklyn, New York.
DOI: 10.5688/ajpe6995
PMCID: PMC6630849
PMID: 31333264
Hayward KL(1)(2), Martin JH(3), Cottrell WN(4), Karmakar A(1), Horsfall LU(5)(6),
Patel PJ(5)(6), Smith DD(7), Irvine KM(5), Powell EE(5)(6), Valery PC(8).
Author information:
(1)School of Medicine, The University of Queensland, Brisbane, QLD, Australia.
(2)Pharmacy Department, Princess Alexandra Hospital, Brisbane, QLD, Australia.
(3)School of Medicine and Public Health, The University of Newcastle, Newcastle,
NSW, Australia.
(4)School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia.
(5)The Centre for Liver Disease Research, Translational Research Institute, The
University of Queensland, Brisbane, QLD, Australia.
(6)Department of Gastroenterology and Hepatology, Princess Alexandra Hospital,
Brisbane, QLD, Australia.
(7)Statistics Unit, QIMR Berghofer Medical Research Institute, Brisbane, QLD,
Australia.
(8)Cancer and Chronic Disease Research Group, Level 4, Central, QIMR Berghofer
Medical Research Institute, 300 Herston Rd, Brisbane, QLD, 4006, Australia.
patricia.valery@qimrberghofer.edu.au.
BACKGROUND: People with decompensated cirrhosis require complex medical care and
are often prescribed an intricate and frequently changing medication and
lifestyle regimen. However, many patients mismanage their medications or have
poor comprehension of their disease and self-management tasks. This can lead to
harm, hospitalization, and death.
METHODS/DESIGN: A patient-oriented education and medication management
intervention has been developed for implementation at a tertiary hospital
hepatology outpatient center in Queensland, Australia. Consenting patients with
decompensated cirrhosis will be randomly allocated to education intervention or
usual care treatment arms when they attend routine follow-up appointments. In the
usual care arm, participants will be reviewed by their hepatologist according to
the current model of care in the hepatology clinic. In the intervention arm,
participants will be reviewed by a clinical pharmacist to receive the education
and medication management intervention at baseline in addition to review by their
hepatologist. Intervention participants will also receive three further
educational contacts from the clinical pharmacist within the following 6-month
period, in addition to routine hepatologist review that is scheduled within this
time frame. All participants will be surveyed at baseline and follow-up
(approximately 6 months post-enrollment). Validated questionnaire tools will be
used to determine participant adherence, medication beliefs, illness perceptions,
and quality of life. Patients' knowledge of dietary and lifestyle modifications,
their current medications, and other clinical data will be obtained from the
survey, patient interview, and medical records. Patient outcome data will be
collected at 52 weeks.
DISCUSSION: The intervention described within this protocol is ready to adapt and
implement in hepatology ambulatory care centers globally. Investigation of
potentially modifiable variables that may impact medication management, in
addition to the effect of a clinical pharmacist-driven education and medication
management intervention on modifying these variables, will provide valuable
information for future management of these patients.
TRIAL REGISTRATION: Australian and New Zealand Clinical Trial Registry
identifier: ACTRN12616000780459 . Registered on 15 June 2016.
DOI: 10.1186/s13063-017-2075-4
PMCID: PMC5520368
PMID: 28728560 [Indexed for MEDLINE]
Sulosaari V(1), Huupponen R(2), Hupli M(3), Puukka P(4), Torniainen K(5),
Leino-Kilpi H(6).
Author information:
(1)Department of Nursing Science, University of Turku, FI-20014, Turku, Finland.
virsul@utu.fi.
(2)Clinical Pharmacology Unit, Department of Pharmacology, Drug Development and
Therapeutics, University of Turku, FI-20014, Turku, Finland.
risto.huupponen@utu.fi.
(3)Department of Nursing Science, University of Turku, FI-20014, Turku, Finland.
maija.hupli@utu.fi.
(4)National Institute for Health and Welfare, PL 57, FI-20521, Turku, Finland.
pauli.puukka@thl.fi.
(5)Hospital Pharmacy Hospital Pharmacy, Turku University Hospital, PO Box 52,
FI-20521, Turku, Finland. kirsti.torniainen@tyks.fi.
(6)Department of Nursing Science, University of Turku, FI-20014, Turku, Finland.
helena.leino-kilpi@utu.fi.
DOI: 10.1186/s12909-015-0513-0
PMCID: PMC4683869
PMID: 26683623 [Indexed for MEDLINE]
Author information:
(1)Cerner Research Consulting, 600 Corporate Pointe, Ste. 320, Culver City, CA
90230. Kat.Aguilar@cerner.com.
DOI: 10.18553/jmcp.2015.21.8.670
PMID: 26233539 [Indexed for MEDLINE]
Author information:
(1)Department for Learning, Informatics, Management and Ethics, Karolinska
Institutet, Stockholm, Sweden.
DOI: 10.3233/JPD-181314
PMCID: PMC6130409
PMID: 30124453
903. Neuropsychiatr Dis Treat. 2017 Mar 7;13:733-736. doi: 10.2147/NDT.S132355.
eCollection 2017.
Author information:
(1)Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki
University, Hirosaki, Japan.
DOI: 10.2147/NDT.S132355
PMCID: PMC5349503
PMID: 28331323
Author information:
(1)University of California-San Diego, San Diego, California.
DOI: 10.5688/ajpe80586
PMCID: PMC4937981
PMID: 27402989 [Indexed for MEDLINE]
Author information:
(1)Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul
Aziz, Kuala Lumpur, Malaysia; Pharmacy Division, Ministry of Health, Jalan
Universiti, Petaling Jaya, Malaysia.
(2)Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul
Aziz, Kuala Lumpur, Malaysia.
DOI: 10.2147/PPA.S103057
PMCID: PMC4874730
PMID: 27313448
Mehat P(1), Atiquzzaman M(1), Esdaile JM(1), AviÑa-Zubieta A(1), De Vera MA(1).
Author information:
(1)University of British Columbia, Vancouver, and Arthritis Research Centre of
Canada, Richmond, British Columbia, Canada.
DOI: 10.1002/acr.23191
PMID: 28086003 [Indexed for MEDLINE]
Author information:
(1)Department of Clinical Pharmacy, School of Pharmacy, College of Health
Sciences, Mekelle University, Mekelle, Tigray, Ethiopia.
(2)Clinical Pharmacy and Pharmacy Practice Unit, Department of Pharmacy, College
of Health Sciences, Aksum University, Aksum, Tigray, Ethiopia.
DOI: 10.1371/journal.pone.0218947
PMCID: PMC6594646
PMID: 31242265
"The More I Do, the Better I'll Be": The Treatment Preferences of Type 2 Diabetes
Among African American Men.
Author information:
(1)1 Texas A&M University, College Station, TX, USA.
To gain better insight to the preferred methods of managing and treating type 2
diabetes among African American men (AA men). Participants ( n = 19) were AA men
aged 35 to 69 years, who were diagnosed with type 2 diabetes. Participants were
recruited via community outreach efforts, including barbershops and churches
located in predominantly African American communities in Southeast United States.
On consent, individual interviews were conducted, audio recorded, and
subsequently transcribed. Transcripts were analyzed using a phenomenological
approach, and focused on identifying common themes among the descriptions of AA
men's experiences specific to type 2 diabetes. Participants' statements indicated
three main commonalities regarding treatment preferences which were medication,
dietary changes, and increase in exercise. Some participants from the study
stated that they preferred taking oral medication primarily out of convenience,
lack of pain, and how well the medicine makes them feel. Others stated educating
themselves and having a consistent relationship with the diabetes physician has
assisted them the most. Other participants shared preferences of being dedicated
to proper diet and exercise without any medication (pill or injection), as well
as maintaining the mental motivation needed to sustain management. Some
participants preferred to not take an oral pill, while some did not mind taking
pills at all. For some of the participants, it appears that it is easier for them
to manage their diabetes by prescription medication than by lifestyle changes
such as diet and exercise. Future studies are needed to investigate how social
support system also assists these men in managing their diabetes.
DOI: 10.1177/1557988316642274
PMCID: PMC6131424
PMID: 27256886 [Indexed for MEDLINE]
Mishra S.
DOI: 10.1016/j.ihj.2017.03.004
PMCID: PMC5415115
PMID: 28460757 [Indexed for MEDLINE]
Author information:
(1)Department of Psychiatry and Human Behavior, Warren Alpert Medical School,
Brown University, 196 Richmond Street, Providence, RI, 02903, USA.
carly_goldstein@brown.edu.
(2)The Weight Control and Diabetes Research Center, The Miriam Hospital,
Providence, RI, 02903, USA. carly_goldstein@brown.edu.
(3)Department of Psychiatry and Human Behavior, Warren Alpert Medical School,
Brown University, 196 Richmond Street, Providence, RI, 02903, USA.
(4)Department of Psychological Sciences, Kent State University, Kent, OH, 44242,
USA.
(5)School of Nursing, Case Western Reserve University, Cleveland, OH, 44106, USA.
(6)Summa Cardiovascular Institute, Akron City Hospital, Summa Health System,
Akron, OH, 44307, USA.
(7)School of Medicine, Case Western Reserve University, Cleveland, OH, 44106,
USA.
(8)Harrington Heart and Vascular Institute, University Hospitals, Cleveland, OH,
44106, USA.
Patients with heart failure (HF) take many medications to manage their HF and
comorbidities, and 20-50% experience depression. Depressed individuals with more
complex medication regimens may be at greater risk for poor adherence. The aim of
this study was to assess depressive symptoms as a moderator of the relationship
between medication regimen complexity and medication adherence in an
observational study of patients with HF. In hierarchical linear regression with
the final sample of 299, the interaction of medication regimen complexity and
depressive symptoms predicted medication adherence, p < .05. For individuals with
higher levels of depressive symptoms [1 standard deviation (SD) above the mean],
more regimen complexity was associated with lower adherence. For individuals with
low (1 SD below the mean) or average levels of depressive symptoms, regimen
complexity was unrelated to medication adherence. Care management strategies,
including pillboxes and caregiver involvement, may be valuable in HF patients
with depression.
DOI: 10.1007/s10865-017-9829-z
PMCID: PMC5873320
PMID: 28190133 [Indexed for MEDLINE]
Pauly A(1), Wolf C(1), Mayr A(2), Lenz B(3), Kornhuber J(3), Friedland K(1).
Author information:
(1)Molecular & Clinical Pharmacy, Friedrich-Alexander University
Erlangen-Nürnberg (FAU), Erlangen, Germany.
(2)Department of Medical Informatics, Biometry and Epidemiology,
Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
(3)Department of Psychiatry and Psychotherapy, Friedrich-Alexander University
Erlangen-Nürnberg (FAU), Erlangen, Germany.
DOI: 10.1371/journal.pone.0139302
PMCID: PMC4593549
PMID: 26437449 [Indexed for MEDLINE]
912. Neurourol Urodyn. 2015 Jun;34(5):424-8. doi: 10.1002/nau.22605. Epub 2014 Apr
9.
Andy UU(1), Harvie HS(1), Smith AL(2), Propert KJ(3), Bogner HR(4), Arya LA(1).
Author information:
(1)Division of Urogynecology, Department of Obstetrics and Gynecology, University
of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
(2)Division of Urology, Department of Surgery, University of Pennsylvania School
of Medicine, Philadelphia, Pennsylvania.
(3)Department of Biostatistics and Epidemiology, University of Pennsylvania
School of Medicine, Philadelphia, Pennsylvania.
(4)Department of Family Medicine and Community Health, University of Pennsylvania
School of Medicine, Philadelphia, Pennsylvania.
DOI: 10.1002/nau.22605
PMCID: PMC4420725
PMID: 24719232 [Indexed for MEDLINE]
Thomson K(1), Brouwers C(#)(2), Damman OC(2), de Bruijne MC(2), Timmermans DR(2),
Melles M(1).
Author information:
(1)Faculty of Industrial Design Engineering, Delft University of Technology,
Delft, Netherlands.
(2)Department of Public and Occupational Health and Amsterdam Public Health
Research Institute, VU University Medical Center, Amsterdam, Netherlands.
(#)Contributed equally
DOI: 10.2196/humanfactors.8948
PMCID: PMC5840481
PMID: 29463494
Author information:
(1)Department of Family Medicine, University of Michigan, Ann Arbor, MI, USA.
Electronic address: aikensj@umich.edu.
(2)Division of General Internal Medicine, University of Michigan, Ann Arbor, MI,
USA; VA Ann Arbor Center for Clinical Management Research, Ann Arbor, MI, USA.
(3)VA Ann Arbor Center for Clinical Management Research, Ann Arbor, MI, USA;
Department of Health Behavior and Health Education, School of Public Health,
University of Michigan, Ann Arbor, MI, USA.
Copyright © 2014 Primary Care Diabetes Europe. Published by Elsevier Ltd. All
rights reserved.
DOI: 10.1016/j.pcd.2014.06.003
PMCID: PMC4303563
PMID: 25065270 [Indexed for MEDLINE]
King-Shier K(1)(2), Quan H(2), Mather C(3), Chong E(4), LeBlanc P(1), Khan N(5).
Author information:
(1)Faculty of Nursing, University of Calgary, Calgary, Canada, kingk@ucalgary.ca.
(2)Department of Community Health Sciences, Cumming School of Medicine,
University of Calgary, Calgary, Canada, kingk@ucalgary.ca.
(3)Department of Anthropology, Faculty of Arts, University of Calgary, Calgary,
Canada.
(4)Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver,
Canada.
(5)Division of General Internal Medicine, Faculty of Medicine, University of
British Columbia, Vancouver, Canada.
DOI: 10.2147/PPA.S169167
PMCID: PMC6135069
PMID: 30233153
Author information:
(1)Department of Medicine, University of Miami Miller School of Medicine, Miami,
FL, USA, APalacio2@med.miami.edu.
DOI: 10.1007/s11606-014-3139-8
PMCID: PMC4370989
PMID: 25500787 [Indexed for MEDLINE]
Letter to Editor. New assessment of the validity of the Brief Measure to Assess
Perception of Self-Influence on the Disease Course: A Version for Schizophrenia.
DOI: 10.12740/PP/43441
PMID: 26276930 [Indexed for MEDLINE]
Author information:
(1)Department of Dermatology, Beijing Friendship Hospital, Capital Medical
University, Beijing 100050, China.
(2)Department of Dermatology, Capital Institute of Pediatrics, Beijing 100020,
China.
DOI: 10.4103/0366-6999.187858
PMCID: PMC4989423
PMID: 27503017 [Indexed for MEDLINE]
919. AMIA Annu Symp Proc. 2017 Feb 10;2016:1959-1966. eCollection 2016.
Author information:
(1)Division of Clinical Informatics, Beth Israel Deaconess Medical Center,
Boston, MA; Harvard Medical School, Boston, MA.
PMCID: PMC5333345
PMID: 28269955 [Indexed for MEDLINE]
Author information:
(1)La Revuelta, Neuquén, Patagonia, Argentina. Electronic address:
ruthlibertaria@gmail.com.
(2)Ibis Reproductive Health, 1330 Broadway Street, Suite 1100, Oakland, CA 94612,
USA. Electronic address: bkeefeoates@ibisreproductivehealth.org.
(3)Ibis Reproductive Health, 1330 Broadway Street, Suite 1100, Oakland, CA 94612,
USA. Electronic address: cgerdts@ibisreproductivehealth.org.
OBJECTIVE: Legal restrictions on abortion access impact the safety and timing of
abortion. Women affected by these laws face barriers to safe care that often
result in abortion being delayed. Second-trimester abortion affects vulnerable
groups of women disproportionately and is often more difficult to access. In
Argentina, where abortion is legally restricted except in cases of rape or threat
to the health of the woman, the Socorristas en Red, a feminist network, offers a
model of accompaniment wherein they provide information and support to women
seeking second-trimester abortions. This qualitative analysis aimed to understand
Socorristas' experiences supporting women who have second-trimester medication
abortion outside the formal health care system.
STUDY DESIGN: We conducted 2 focus groups with 16 Socorristas in total to
understand experiences accompanying women having second-trimester medication
abortion who were at 14-24 weeks' gestational age. We performed a thematic
analysis of the data and present key themes in this article.
RESULTS: The Socorristas strived to ensure that women had the power of choice in
every step of their abortion. These cases required more attention and logistical,
legal and medical risks than first-trimester care. The Socorristas learned how to
help women manage the possibility of these risks and were comfortable providing
this support. They understood their work as activism through which they aim to
destigmatize abortion and advocate against patriarchal systems denying the right
to abortion.
CONCLUSION: Socorrista groups have shown that they can provide supportive,
women-centered accompaniment during second-trimester medication abortions outside
the formal health care system in a setting where abortion access is legally
restricted.
IMPLICATIONS: Second-trimester self-use of medication abortion outside of the
formal health system supported by feminist activist groups could provide an
alternative model for second-trimester care worldwide. More research is needed to
document the safety and effectiveness of this accompaniment service-provision
model.
Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.contraception.2017.07.170
PMID: 28801052 [Indexed for MEDLINE]
Cook PF(1), Schmiege SJ(1), Mansberger SL(2), Sheppler C(2), Kammer J(3),
Fitzgerald T(4), Kahook MY(5).
Author information:
(1)a College of Nursing , University of Colorado , Aurora , CO , USA.
(2)b Devers Eye Institute, Legacy Health , Portland , OR , USA.
(3)c Vanderbilt Eye Institute , Vanderbilt University , Nashville , TN , USA.
(4)d Global Health Outcomes , Merck & Co. Inc. , White Horse Station , NJ , USA.
(5)e School of Medicine , University of Colorado , Aurora , CO , USA.
DOI: 10.1080/08870446.2016.1244537
PMCID: PMC5560586
PMID: 27701902 [Indexed for MEDLINE]
Author information:
(1)Indiana University School of Nursing, International Center for Intercultural
Communication, Indiana University, Indianapolis, IN, USA.
(2)Indiana University School of Liberal Arts, International Center for
Intercultural Communication, Indiana University, Indianapolis, IN, USA.
DOI: 10.2147/PPA.S69291
PMCID: PMC4199751
PMID: 25336928
Author information:
(1)Department of Medicine, Vanderbilt University Medical Center, Nashville,
Tennessee, USA. Electronic address: lindsay.mayberry@vanderbilt.edu.
(2)Department of Medicine, Vanderbilt University Medical Center, Nashville,
Tennessee, USA; Department of Biomedical Informatics, Vanderbilt University
Medical Center, Nashville, Tennessee, USA; Center for Health Behavior and Health
Education, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
DOI: 10.1016/j.pec.2014.09.011
PMCID: PMC4254324
PMID: 25282327 [Indexed for MEDLINE]
924. Br J Gen Pract. 2015 Nov;65(640):e776-83. doi: 10.3399/bjgp15X687433.
Author information:
(1)Primary Care Clinical Sciences, University of Birmingham, Birmingham.
(2)Department of Psychology, School of Science and Technology, Middlesex
University London, London.
(3)Nuffield Department of Primary Care Health Sciences, NIHR School for Primary
Care Research, University of Oxford, Oxford.
DOI: 10.3399/bjgp15X687433
PMCID: PMC4617273
PMID: 26500326 [Indexed for MEDLINE]
Zhang L(1), Li X(1)(2), Lin Z(1)(3), Jacques-Tiura AJ(1), Xu J(4), Zhou Y(5),
Qiao S(1)(2), Shen Z(5), Stanton B(1).
Author information:
(1)a The Carman and Ann Adams Department of Pediatrics , Wayne State University
School of Medicine , Detroit , MI , USA.
(2)b Arnold School of Public Health , University of South Carolina , Columbia ,
SC , USA.
(3)c Center for Health Policy Research , Nanjing Medical University , Nanjing ,
People's Republic of China.
(4)d Department of Family Medicine and Public Health Sciences , Wayne State
University School of Medicine , Detroit , MI , USA.
(5)e Guangxi Center for Disease Control and Prevention , Nanning , People's
Republic of China.
DOI: 10.1080/09540121.2015.1124984
PMCID: PMC6065505
PMID: 27010870 [Indexed for MEDLINE]
Author information:
(1)Professor of Psychiatry, Department of Internal Medicine, Dermatology and
Psychiatry, University of La Laguna, Canary Islands, Spain.
cdelascuevas@gmail.com.
(2)Red de Investigación en Servicios de Salud en Enfermedades Crónicas
(REDISSEC), Tenerife, Spain. cdelascuevas@gmail.com.
(3)Professor of Psychology, Department of Personality, Assessment and
Psychological Treatments, University of La Laguna, Canary Islands, Spain.
wpenate@ull.es.
(4)Professor of Clinical Pharmacology, Department of Physical Medicine and
Pharmacology, University of La Laguna, Canary Islands, Spain. ejsanz@gmail.com.
Comment in
Evid Based Nurs. 2015 Oct;18(4):113.
BACKGROUND: Although non-adherence to antidepressant medications is a significant
barrier to the successful treatment of depression in clinical practice, few
potentially modifiable predictors of poor adherence to antidepressant treatment
are known. The aim of this study was to examine the relationship of psychological
reactance, health locus of control and the sense of self-efficacy on adherence to
treatment regimen among psychiatric outpatients with depression.
METHODS: One hundred and forty-five consecutive psychiatric outpatients suffering
from depressive disorders were invited to participate in a cross-sectional study
and 119 accepted. Patients completed a series of self-reported questionnaires
assessing psychological reactance, health locus of control, self-efficacy, and
adherence to prescribed medication in addition to socio-demographic and clinical
variables. Logistic regression analyses were performed to determine which factors
better correlate to treatment adherence.
RESULTS: Age was found to be the best correlate of adherence to prescribed
treatment. As regards psychological dimension studied, medication adherence was
negatively associated with both cognitive and affective psychological reactance;
patients with higher psychological reactance were more likely to be noncompliant
than patients showing a low level of psychological reactance. Regarding health
locus of control, only the external dimension of doctor-attributed health locus
of control was positively associated with medications adherence. No effect on
adherence was observed for the self-efficacy scale.
CONCLUSIONS: Psychological reactance is an important correlate of adherence to
treatment in patients with depressive disorders and this needs to be considered
when giving clinical advice in order to avoid inducing reactance and thus
non-adherence to prescribed treatments. Mental health professionals need to learn
about communication techniques and counseling skills that enable them to deal
with the psychological reactance of their patients.
DOI: 10.1186/s12888-014-0324-6
PMCID: PMC4243370
PMID: 25412702 [Indexed for MEDLINE]
Bollmeier SG, Seaton TL, Prosser TR, Chou YT, Reckenberg K, Hahn B, Stanford RH,
Ray R.
DOI: 10.1016/j.japh.2019.04.017
PMID: 31126830
Author information:
(1)Department of Physical Therapy, Faculty of Medicine, University of British
Columbia, 212 Friedman Building, 2177 Wesbrook Mall, Vancouver, BC, V6T 1Z3,
Canada.
(2)Faculty of Health Sciences, Simon Fraser University, c/o Healthy Heart
Program, St. Paul's Hospital 180 - 1081 Burrard Street, Vancouver, BC, V6Z 1Y6,
Canada.
(3)Rehabilitation Research Program, GF Strong Rehabilitation Research Lab,
Vancouver Coastal Health Research Institute, 4255 Laurel Street, Vancouver, BC,
V5Z 2G9, Canada.
(4)Department of Physical Therapy, Faculty of Medicine, University of British
Columbia, 212 Friedman Building, 2177 Wesbrook Mall, Vancouver, BC, V6T 1Z3,
Canada. janice.eng@ubc.ca.
(5)Rehabilitation Research Program, GF Strong Rehabilitation Research Lab,
Vancouver Coastal Health Research Institute, 4255 Laurel Street, Vancouver, BC,
V5Z 2G9, Canada. janice.eng@ubc.ca.
DOI: 10.1007/s12529-016-9582-7
PMCID: PMC5762183
PMID: 27469998 [Indexed for MEDLINE]
929. Pharmacy (Basel). 2017 Apr 6;5(2). pii: E20. doi: 10.3390/pharmacy5020020.
Harlow C(1), Hanna C(2), Eckmann L(3), Gokun Y(4), Zanjani F(5), Blumenschein
K(6), Divine H(7).
Author information:
(1)St. Matthews Community Pharmacy, Louisville, KY 40207, USA.
cpharlow@gmail.com.
(2)American Pharmacy Services Corporation, Frankfort, KY 40601, USA.
channa@apscnet.com.
(3)Wheeler Pharmacy, Home Connection, Lexington, KY 40507, USA. eckmann8@aol.com.
(4)General Dynamics Information Technology, Little Rock, AR 72205, USA.
jane.gokun@gdit.com.
(5)Department of Behavioral and Community Health, University of Maryland School
of Public Health, College Park, MD 20742, USA. fzanjani@umd.edu.
(6)Department of Pharmacy Practice and Science, University of Kentucky College of
Pharmacy Lexington, KY 40536, USA. KBLUM1@uky.edu.
(7)Department of Pharmacy Practice and Science, University of Kentucky College of
Pharmacy Lexington, KY 40536, USA. holly.divine@uky.edu.
This study sought to understand the medication adherence and quality of life
(QOL) of recipients of a pharmacist-based medication management program among
independently living older adults. Using a cross-sectional, quasi-experimental
study design, we compared older adults enrolled in the program to older adults
not enrolled in the program. Data were collected via face-to-face interviews in
independent-living facilities and in participants' homes. Independently living
older adults who were enrolled in the medication management program (n = 38) were
compared to older adults not enrolled in the program (control group (n = 41)).
All participants were asked to complete questionnaires on health-related quality
of life (QOL, using the SF-36) and medication adherence (using the four-item
Morisky scale). The medication management program recipients reported
significantly more prescribed medications (p < 0.0001) and were more likely to
report living alone (p = 0.01) than the control group. The medication management
program recipients had a significantly lower SF-36 physical functioning score (p
= 0.03) compared to the control group, although other SF-36 domains and
self-reported medication adherence were similar between the groups. Despite
taking more medications and more commonly living alone, independent living older
adults enrolled in a pharmacist-based medication management program had similar
QOL and self-reported medication adherence when compared to older adults not
enrolled in the program. This study provides initial evidence for the
characteristics of older adults receiving a pharmacist-based medication
management program, which may contribute to prolonged independent living and
positive health outcomes.
DOI: 10.3390/pharmacy5020020
PMCID: PMC5597145
PMID: 28970432
Bidwell JT(1), Higgins MK(2), Reilly CM(3), Clark PC(4), Dunbar SB(5).
Author information:
(1)Emory University, Nell Hodgson Woodruff School of Nursing, 1520 Clifton Road,
Atlanta, GA, 30322, United States. Electronic address: jtbidwe@emory.edu.
(2)Emory University, Nell Hodgson Woodruff School of Nursing, 1520 Clifton Road,
Atlanta, GA, 30322, United States. Electronic address: mkhiggi@emory.edu.
(3)Emory University, Nell Hodgson Woodruff School of Nursing, 1520 Clifton Road,
Atlanta, GA, 30322, United States. Electronic address: cmill02@emory.edu.
(4)Georgia State University, Byrdine F. Lewis College of Nursing and Health
Professions, P.O. Box 3995, Atlanta, GA, 30302, United States. Electronic
address: pclark@gsu.edu.
(5)Emory University, Nell Hodgson Woodruff School of Nursing, 1520 Clifton Road,
Atlanta, GA, 30322, United States. Electronic address: sbdunba@emory.edu.
DOI: 10.1016/j.hrtlng.2017.11.001
PMCID: PMC5722704
PMID: 29153759 [Indexed for MEDLINE]
Author information:
(1)Department of Health Behavior, University of North Carolina at Chapel Hill,
312 Rosenau Hall, CB#7440, Chapel Hill, NC, 27599-7440, USA. cleos@email.unc.edu.
(2)Thurston Arthritis Research Center, University of North Carolina at Chapel
Hill, Chapel Hill, NC, USA.
(3)Department of Health Behavior, University of North Carolina at Chapel Hill,
312 Rosenau Hall, CB#7440, Chapel Hill, NC, 27599-7440, USA.
(4)Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel
Hill, Chapel Hill, NC, USA.
DOI: 10.1007/s10865-015-9698-2
PMCID: PMC4801749
PMID: 26646840 [Indexed for MEDLINE]
932. Diabetes Technol Ther. 2014 Oct;16(10):653-60. doi: 10.1089/dia.2014.0045.
Epub
2014 Jul 3.
The Utah Remote Monitoring Project: improving health care one patient at a time.
Author information:
(1)1 Department of Pharmacotherapy, University of Utah College of Pharmacy , Salt
Lake City, Utah.
DOI: 10.1089/dia.2014.0045
PMCID: PMC4183896
PMID: 24991923 [Indexed for MEDLINE]
Persell SD(1)(2), Karmali KN(3), Lazar D(4), Friesema EM(1)(2)(5), Lee JY(1),
Rademaker A(6), Kaiser D(7), Eder M(4)(8), French DD(9), Brown T(1), Wolf MS(1).
Author information:
(1)Division of General Internal Medicine and Geriatrics, Department of Medicine,
Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
(2)Center for Primary Care Innovation, Institute for Public Health and Medicine,
Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
(3)Division of Cardiology, Department of Medicine, Feinberg School of Medicine,
Northwestern University, Chicago, Illinois.
(4)Access Community Health Network and the Access Center for Discovery and
Learning, Chicago, Illinois.
(5)Carlson School of Management, University of Minnesota, Minneapolis.
(6)Department of Preventive Medicine, Feinberg School of Medicine, Northwestern
University, Chicago, Illinois.
(7)Information Services, Northwestern Memorial Healthcare, Chicago, Illinois.
(8)Center for Excellence in Primary Care, Department of Family Medicine and
Community Health, Medical School, University of Minnesota, Minneapolis.
(9)Department of Ophthalmology and Center for Healthcare Studies, Feinberg School
of Medicine, Northwestern University, Chicago, Illinois.
Comment in
JAMA Intern Med. 2018 Nov 1;178(11):1562-1563.
JAMA Intern Med. 2018 Nov 1;178(11):1563.
DOI: 10.1001/jamainternmed.2018.2372
PMCID: PMC6143105
PMID: 29987324
van Eikenhorst L(1), Taxis K(1), van Dijk L(2), de Gier H(1).
Author information:
(1)Unit of PharmacoTherapy, -Epidemiology and -Economics, Groningen Research
Institute of Pharmacy, University of Groningen, Groningen, Netherlands.
(2)Pharmaceutical Care, NIVEL, Netherlands Institute for Health Services
Research, Utrecht, Netherlands.
DOI: 10.3389/fphar.2017.00891
PMCID: PMC5735079
PMID: 29311916
Côté J(1)(2)(3), Fortin MC(3)(4), Auger P(1)(3), Rouleau G(1)(3), Dubois S(2),
Boudreau N(4), Vaillant I(4), Gélinas-Lemay É(4).
Author information:
(1)Research Chair in Innovative Nursing Practices, Montreal, QC, Canada.
(2)Faculty of Nursing, Université de Montréal, Montreal, QC, Canada.
(3)Research Centre of the Centre Hospitalier de l'Université de Montréal,
Montreal, QC, Canada.
(4)Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
DOI: 10.2196/formative.9707
PMCID: PMC6334708
PMID: 30684400
936. BMC Health Serv Res. 2018 Jul 31;18(1):592. doi: 10.1186/s12913-018-3380-7.
Reliability and validity of a 12-item medication adherence scale for patients
with chronic disease in Japan.
Ueno H(1), Yamazaki Y(2), Yonekura Y(3), Park MJ(4), Ishikawa H(5)(6), Kiuchi
T(5).
Author information:
(1)Department of Health Communication, Graduate School of Medicine, The
University of Tokyo, Tokyo, Japan. uenoh-tky@umin.ac.jp.
(2)Faculty of Social Welfare, Nihon Fukushi University, Mihama, Japan.
(3)Graduate School of Nursing Science, St. Luke's International University,
Tokyo, Japan.
(4)College of Nursing, Konyang University, Daejeon, South Korea.
(5)Department of Health Communication, Graduate School of Medicine, The
University of Tokyo, Tokyo, Japan.
(6)Graduate School of Public Health, Teikyo University, Tokyo, Japan.
DOI: 10.1186/s12913-018-3380-7
PMCID: PMC6069892
PMID: 30064422 [Indexed for MEDLINE]
Bosworth HB(1), Brown JN, Danus S, Sanders LL, McCant F, Zullig LL, Olsen MK.
Author information:
(1)Durham Veterans Affairs Medical Center, 411 W Chapel Hill St, Ste 600, Durham,
NC 27701. E-mail: boswo001@mc.duke.edu.
Mobile Health Technology for Improving Symptom Management in Low Income Persons
Living with HIV.
Schnall R(1), Cho H(2), Mangone A(2), Pichon A(2), Jia H(2).
Author information:
(1)Columbia University School of Nursing, New York, NY, 10032, USA.
rb897@columbia.edu.
(2)Columbia University School of Nursing, New York, NY, 10032, USA.
Persons living with HIV (PLWH) are living longer but experiencing more adverse
symptoms associated with the disease and its treatment. This study aimed to
examine the impact of a mHealth application (app) comprised of evidence-based
self-care strategies on the symptom experience of PLWH. We conducted a 12-week
feasibility study with 80 PLWH who were randomized (1:1) to a mHealth app, mobile
Video Information Provider (mVIP), with self-care strategies for improving 13
commonly experienced symptoms in PLWH or to a control app. Intervention group
participants showed a significantly greater improvement than the control group in
5 symptoms: anxiety (p = 0.001), depression (p = 0.001), neuropathy (p = 0.002),
fever/chills/sweat (p = 0.037), and weight loss/wasting (p = 0.020). Participants
in the intervention group showed greater improvement in adherence to their
antiretroviral medications (p = 0.017) as compared to those in the control group.
In this 12-week trial, mVIP was associated with improved symptom burden and
increased medication adherence in PLWH.
DOI: 10.1007/s10461-017-2014-0
PMCID: PMC6034982
PMID: 29299790 [Indexed for MEDLINE]
Holcomb LS(1).
Author information:
(1)College of Nursing and Health Professions, Valparaiso University, Valparaiso,
IN, USA Linda.Holcomb@valpo.edu.
DOI: 10.1177/1932296815585132
PMCID: PMC4667321
PMID: 25934517 [Indexed for MEDLINE]
Author information:
(1)Family Medicine Department, Faculty of Medicine, Suez Canal University,
Ismailia, Egypt.
DOI: 10.11604/pamj.2015.20.177.4025
PMCID: PMC4469448
PMID: 26113919 [Indexed for MEDLINE]
Salgado TM(1), Fedrigon A(2), Riccio Omichinski D(3), Meade MA(3), Farris KB(4).
Author information:
(1)Department of Pharmacotherapy & Outcomes Science, School of Pharmacy, Virginia
Commonwealth University, Richmond, VA, United States.
(2)College of Pharmacy, University of Michigan, Ann Arbor, MI, United States.
(3)Department of Physical Medicine & Rehabilitation, University of Michigan
Rehabilitation Engineering Research Center, University of Michigan, Ann Arbor,
MI, United States.
(4)Department of Clinical Pharmacy, College of Pharmacy, University of Michigan,
Ann Arbor, MI, United States.
DOI: 10.2196/mhealth.9527
PMCID: PMC5990856
PMID: 29792292
942. Biomed Res Int. 2015;2015:217047. doi: 10.1155/2015/217047. Epub 2015 Oct 11.
Author information:
(1)UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK.
(2)Department of Drug Sciences, Laboratory of Pharmacology, Faculty of Pharmacy,
University of Porto, Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
WHO reported that adherence among patients with chronic diseases averages only
50% in developed countries. This is recognized as a significant public health
issue, since medication nonadherence leads to poor health outcomes and increased
healthcare costs. Improving medication adherence is, therefore, crucial and
revealed on many studies, suggesting interventions can improve medication
adherence. One significant aspect of the strategies to improve medication
adherence is to understand its magnitude. However, there is a lack of general
guidance for researchers and healthcare professionals to choose the appropriate
tools that can explore the extent of medication adherence and the reasons behind
this problem in order to orchestrate subsequent interventions. This paper reviews
both subjective and objective medication adherence measures, including direct
measures, those involving secondary database analysis, electronic medication
packaging (EMP) devices, pill count, and clinician assessments and self-report.
Subjective measures generally provide explanations for patient's nonadherence
whereas objective measures contribute to a more precise record of patient's
medication-taking behavior. While choosing a suitable approach, researchers and
healthcare professionals should balance the reliability and practicality,
especially cost effectiveness, for their purpose. Meanwhile, because a perfect
measure does not exist, a multimeasure approach seems to be the best solution
currently.
DOI: 10.1155/2015/217047
PMCID: PMC4619779
PMID: 26539470 [Indexed for MEDLINE]
Author information:
(1)Department of Social and Preventive Medicine, Faculty of Medicine, University
of Malaya, Jalan Universiti, Wilayah Persekutuan, Kuala Lumpur, Malaysia.
DOI: 10.1371/journal.pone.0175096
PMCID: PMC5376339
PMID: 28362861 [Indexed for MEDLINE]
Author information:
(1)1Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
(2)2Research Center for Rational Use of Drugs, Tehran University of Medical
Sciences, 4th floor, No 92, Karimkhan Zand Ave., Hafte Tir Sq., Tehran, Iran.
(3)3Department of Epidemiology and Biostatistics, Faculty of Health, Tehran
University of Medical Sciences, Tehran, Iran.
(4)4Department of Community Health Sciences UCLA Fielding School of Public
Health, Los Angeles, CA USA.
DOI: 10.1007/s40200-018-0356-4
PMCID: PMC6405390 [Available on 2019-10-25]
PMID: 30918851
Author information:
(1)Centre de Recherche, Institut Universitaire de Gériatrie de Montréal,
Montréal, Quebec, Canada.
(2)Faculté de Pharmacie, Université de Montréal, Montréal, Quebec, Canada.
(3)Faculté de Médicine, Université de Montréal, Montréal, Quebec, Canada.
© 2017 The Authors. Journal of the American Geriatrics Society published by Wiley
Periodicals, Inc. on behalf of The American Geriatrics Society.
DOI: 10.1111/jgs.15079
PMCID: PMC5763385
PMID: 28913911 [Indexed for MEDLINE]
Use of Complementary Health Approaches Among Diverse Primary Care Patients with
Type 2 Diabetes and Association with Cardiometabolic Outcomes: From the SF Bay
Collaborative Research Network (SF Bay CRN).
Handley MA(1), Quan J(2), Chao MT(2), Ratanawongsa N(2), Sarkar U(2), Emmons-Bell
S(2), Schillinger D(2).
Author information:
(1)From General Internal Medicine and UCSF Center for Vulnerable Populations at
San Francisco Zuckerberg General Hospital and Trauma Center, University of
California, San Francisco, CA (MAH, JQ, MTC, NR, US, DS); the Department of
Epidemiology and Biostatistics, Division of Preventive Medicine and Public
Health, University of California, San Francisco (MAH, SE); and Osher Center for
Integrative Medicine, University of California, San Francisco (MTC).
margaret.handley@ucsf.edu.
(2)From General Internal Medicine and UCSF Center for Vulnerable Populations at
San Francisco Zuckerberg General Hospital and Trauma Center, University of
California, San Francisco, CA (MAH, JQ, MTC, NR, US, DS); the Department of
Epidemiology and Biostatistics, Division of Preventive Medicine and Public
Health, University of California, San Francisco (MAH, SE); and Osher Center for
Integrative Medicine, University of California, San Francisco (MTC).
DOI: 10.3122/jabfm.2017.05.170030
PMID: 28923815 [Indexed for MEDLINE]
Musich S(1), Cheng Y, Wang SS, Hommer CE, Hawkins K, Yeh CS.
Author information:
(1)Advanced Analytics, Optum, 315 E. Eisenhower Parkway, Suite 305, Ann Arbor,
MI, 48108, USA, shirley.musich@optum.com.
Comment in
J Gen Intern Med. 2015 Aug;30(8):1045-6.
DOI: 10.1007/s11606-015-3196-7
PMCID: PMC4510208
PMID: 25666213 [Indexed for MEDLINE]
948. Int J Environ Res Public Health. 2017 Dec 6;14(12). pii: E1522. doi:
10.3390/ijerph14121522.
Gu L(1), Wu S(2), Zhao S(3), Zhou H(4), Zhang S(5), Gao M(6), Qu Z(7), Zhang
W(8), Tian D(9).
Author information:
(1)China Institute of Health, School of Social Development and Public Policy,
Beijing Normal University, 19 Xinjiekou Wai Street, Haidian District, Beijing
100875, China. gulinni@hotmail.com.
(2)China Institute of Health, School of Social Development and Public Policy,
Beijing Normal University, 19 Xinjiekou Wai Street, Haidian District, Beijing
100875, China. wushaominsd@163.com.
(3)School of Public administration, Shandong Technology and Business University,
191 Binhaizhong Road, Yantai 264000, China. pingyuanzhaosan@163.com.
(4)China Institute of Health, School of Social Development and Public Policy,
Beijing Normal University, 19 Xinjiekou Wai Street, Haidian District, Beijing
100875, China. chouhuixuan@live.cn.
(5)China Institute of Health, School of Social Development and Public Policy,
Beijing Normal University, 19 Xinjiekou Wai Street, Haidian District, Beijing
100875, China. zhangshengfa1988@sina.com.
(6)China Institute of Health, School of Social Development and Public Policy,
Beijing Normal University, 19 Xinjiekou Wai Street, Haidian District, Beijing
100875, China. vivianhbs@126.com.
(7)China Institute of Health, School of Social Development and Public Policy,
Beijing Normal University, 19 Xinjiekou Wai Street, Haidian District, Beijing
100875, China. qzy@bnu.edu.cn.
(8)China Institute of Health, School of Social Development and Public Policy,
Beijing Normal University, 19 Xinjiekou Wai Street, Haidian District, Beijing
100875, China. zwj@bnu.edu.cn.
(9)China Institute of Health, School of Social Development and Public Policy,
Beijing Normal University, 19 Xinjiekou Wai Street, Haidian District, Beijing
100875, China. tian65216@hotmail.com.
DOI: 10.3390/ijerph14121522
PMCID: PMC5750940
PMID: 29211039 [Indexed for MEDLINE]
Author information:
(1)1 Division of Pediatric Rheumatology, Monroe Carell Jr. Children's Hospital at
Vanderbilt, Nashville, TN, USA.
(2)2 Vanderbilt University Medical Center, Nashville, TN, USA.
(3)3 Department of Biostatistics, Vanderbilt University, Nashville, TN, USA.
(4)4 Vanderbilt University School of Medicine, Nashville, TN, USA.
(5)5 Department of Health Policy, Vanderbilt University School of Medicine,
Nashville, TN, USA.
DOI: 10.1177/0961203318779710
PMCID: PMC6084794
PMID: 29954282 [Indexed for MEDLINE]
Fu N(1), Jacobson K(1), Round A(1), Evans K(1), Qian H(1), Bressler B(1).
Author information:
(1)Nancy Fu, Brian Bressler, Division of Gastroenterology, Department of
Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
DOI: 10.3748/wjg.v23.i29.5405
PMCID: PMC5550790
PMID: 28839441 [Indexed for MEDLINE]
Author information:
(1)Department of Pediatrics, Medical University of Warsaw, Warsaw.
(2)Clinical Pediatric Hospital, Warsaw.
INTRODUCTION: The way parents manage diabetes of their small children and
environmental influence are crucial for maintaining glycemic control. The aim of
the study was to assess environmental factors affecting metabolic control of
young children with T1D treated with insulin pumps.
MATERIAL AND METHODS: Parents of children with T1D under the age of 10 years
completed: General Self-Efficacy Scale, Parental Diabetes Quality of Life
Questionnaire, Beck Depression Inventory and a questionnaire on socioeconomic
factors.
RESULTS: There were analyzed 165 questionnaires. 66% of children achieved HbA1c
<7.5% (<58mmol/mol). Factors associated with HbA1c≥7.5% (≥58mmol/mol) in the
multiple logistic regression: single-parent families (p=0.003), low income
<250EURO (p=0.017), parental education (p<0.05), snacking without parents'
permission (p=0.0006) and in parents of children ≥6 year of age - quality of life
(p=0.037). In families of children <6 year of age, parents had higher
self-efficacy than parents of children ≥6 year of age (p=0.046).
CONCLUSIONS: Parents of young children are not homogeneous group and face
different challenges. Young children of parents withlower education level and
living in single-parent families are at high risk of poor diabetes management.
More attention should be paid to the problem of young children snacking without
parents' permission.
ABBREVIATIONS: BDI - Beck Depression Inventory, CI-Confidence Intervals, GSES -
General Self-Efficacy Scale, HbA1c - glycated hemoglobin, OR- Odds Ratio, PDQOLQ
- Parental Diabetes Quality of Life Questionnaire, T1D - type 1 diabetes.
DOI: 10.18544/PEDM-23.01.0070
PMID: 29073304 [Indexed for MEDLINE]
Author information:
(1)Associate Professor of Practice, Department of Pharmacy Practice, North Dakota
State University, Fargo, North Dakota, amy.werremeyer@ndsu.edu.
(2)Assistant Professor, Department of Sociology, North Dakota State University,
Fargo, North Dakota.
(3)Associate Professor of Practice, Department of Pharmacy Practice, North Dakota
State University, Fargo, North Dakota.
DOI: 10.9740/mhc.2016.05.142
PMCID: PMC6007651
PMID: 29955462
Author information:
(1)Centre for Psychiatry South-Wuerttemberg, Ravensburg, Germany.
(2)Centre for Psychiatry South-Wuerttemberg, Ravensburg, Germany ; Ulm
University, Department Psychiatry I, Ravensburg, Germany.
DOI: 10.2147/PPA.S75616
PMCID: PMC4386772
PMID: 25848233
Utilizing the common sense model to explore African Americans' perception of type
2 diabetes: A qualitative study.
Author information:
(1)Division of Social and Administrative Sciences, University of
Wisconsin-Madison, Madison, WI, United States of America.
(2)Department of Nursing, University of Wisconsin-Madison, Madison, WI, United
States of America.
(3)Division of Health Outcomes and Pharmacy Practice, University of Texas-Austin,
Austin, TX, United States of America.
DOI: 10.1371/journal.pone.0207692
PMCID: PMC6248983
PMID: 30462704 [Indexed for MEDLINE]
955. Eur J Cancer Care (Engl). 2017 Jan;26(1). doi: 10.1111/ecc.12348. Epub 2015
Aug
4.
Author information:
(1)Ergonomics and Aerosol Technology, Department of Design Sciences, Faculty of
Engineering, Lund University, Lund, Sweden.
(2)Ternova Lund, Blentarp, Sweden.
A better understanding of why medication errors (MEs) occur will mean that we can
work proactively to minimise them. This study developed a proactive tool to
identify general failure types (GFTs) in the process of managing cytotoxic drugs
in healthcare. The tool is based on Reason's Tripod Delta tool. The GFTs and
active failures were identified in 60 cases of MEs reported to the Swedish
national authorities. The most frequently encountered GFTs were defences,
procedures, organisation and design. Working conditions were often the common
denominator underlying the MEs. Among the active failures identified, a majority
were classified as slips, one-third as mistakes, and for a few no active failure
or error could be determined. It was found that the tool facilitated the
qualitative understanding of how the organisational weaknesses and local
characteristics influence the risks. It is recommended that the tool be used
regularly. We propose further development of the GFT tool. We also propose a tool
to be further developed into a proactive self-evaluation tool that would work as
a complement to already incident reporting and event and risk analyses.
© 2015 The Authors. European Journal of Cancer Care Published by John Wiley &
Sons Ltd.
DOI: 10.1111/ecc.12348
PMCID: PMC5298025
PMID: 26239427 [Indexed for MEDLINE]
Do We Have a Clue: The Treatment Burden for the Patient With Cancer?
Author information:
(1)Author Affiliations: Department of Family Medicine, College of Human Medicine
(Dr C. W. Given), and College of Nursing (Drs B. A. Given and Hershey and Mr
Vachon), Michigan State University, East Lansing.
DOI: 10.1097/NCC.0000000000000408
PMCID: PMC4994973
PMID: 27542146 [Indexed for MEDLINE]
Moore DB(1), Neustein RF(2), Jones SK(1), Robin AL(3), Muir KW(4).
Author information:
(1)Duke Eye Center, Duke University Medical Center, Durham, NC, USA.
(2)Emory School of Medicine, Atlanta, GA, USA.
(3)Department of Ophthalmology, Johns Hopkins School of Medicine and
International Health, Bloomberg School of Public Health, Baltimore, MD, USA.
(4)Duke Eye Center, Duke University Medical Center, Durham, NC, USA ; Health
Services Research & Development, Durham VA Medical Center, Durham, NC, USA.
As they grow older, most children with glaucoma must eventually face the
transition to self-administering medications. We previously reported factors
associated with better or worse medication adherence in children with glaucoma,
using an objective, electronic monitor. Utilizing the same data set, the purpose
of the current study was to determine whose report (the caregiver's or the
child's) corresponded better with electronically monitored adherence. Of the 46
participants (22 girls), the mean age of children primarily responsible, and
caregiver primarily responsible for medication administration was 15±2 and 10±2
years, respectively. For the children whose caregiver regularly administered the
eyedrops, the caregiver's assessment of drop adherence was associated with
measured adherence (P=0.012), but the child's was not (P=0.476). For the children
who self-administered eyedrops, neither the child's (P=0.218) nor the caregiver's
(P=0.395) assessment was associated with measured percent adherence. This study
highlights potential errors when relying on self-reporting of compliance in
patients and caregivers with pediatric glaucoma, particularly when the child is
responsible for administering their own eyedrops. Frank discussions about the
importance of medication adherence and how to improve compliance may help both
the child and caregiver better communicate with the treating provider.
DOI: 10.2147/OPTH.S93038
PMCID: PMC4664503
PMID: 26648687
Author information:
(1)Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical
University, Wroclaw, Poland.
(2)Department of Internal Medicine, Occupational Diseases, Hypertension and
Clinical Oncology, Wroclaw Medical University, Wroclaw, Poland. Email:
aszyman@mp.pl.
DOI: 10.5830/CVJA-2018-050
PMID: 30720844
Author information:
(1)Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul
National University, Seoul, Korea.
DOI: 10.2147/PPA.S137263
PMCID: PMC5505608
PMID: 28740366
Author information:
(1)School of Psychology, Faculty of Medicine and Health, University of Leeds,
Leeds, United Kingdom.
DOI: 10.2196/jmir.4963
PMCID: PMC4923591
PMID: 27298211 [Indexed for MEDLINE]
Author information:
(1)The Sterling Research Group and University of Cincinnati, Cincinnati, Ohio.
Electronic address: eroth@sterlingresearch.org.
(2)Sanofi, Paris, France.
(3)Regeneron Pharmaceuticals, Inc, Tarrytown, New York.
(4)Department of Endocrinology, l'Institut du Thorax, Nantes University Hospital,
Nantes, France.
Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.clinthera.2015.07.008
PMID: 26278513 [Indexed for MEDLINE]
Author information:
(1)Institute of Health and Care Science, Sahlgrenska Academy, University of
Gothenburg , Sweden.
DOI: 10.3109/08037051.2014.883203
PMCID: PMC4196574
PMID: 24564289 [Indexed for MEDLINE]
963. Int J Environ Res Public Health. 2019 Apr 6;16(7). pii: E1226. doi:
10.3390/ijerph16071226.
Chandler J(1), Sox L(2), Kellam K(3), Feder L(4), Nemeth L(5), Treiber F(6).
Author information:
(1)College of Nursing, Medical University of South Carolina, Charleston, SC
29425, USA. chandlje@musc.edu.
(2)College of Nursing, Medical University of South Carolina, Charleston, SC
29425, USA. soxl@musc.edu.
(3)College of Nursing, Medical University of South Carolina, Charleston, SC
29425, USA. kellam@musc.edu.
(4)College of Nursing, Medical University of South Carolina, Charleston, SC
29425, USA. feder@musc.edu.
(5)College of Nursing, Medical University of South Carolina, Charleston, SC
29425, USA. nemethl@musc.edu.
(6)College of Nursing, Medical University of South Carolina, Charleston, SC
29425, USA. treiberf@musc.edu.
DOI: 10.3390/ijerph16071226
PMCID: PMC6479738
PMID: 30959858 [Indexed for MEDLINE]
"I did not want to take that medicine": African-Americans' reasons for diabetes
medication nonadherence and perceived solutions for enhancing adherence.
Author information:
(1)Division of Social and Administrative Sciences, School of Pharmacy, University
of Wisconsin-Madison, Madison, WI, USA.
(2)Division of Health Outcomes and Pharmacy Practice, College of Pharmacy,
University of Texas at Austin, Austin, TX, USA.
(3)School of Nursing, University of Wisconsin-Madison, Madison, WI, USA.
DOI: 10.2147/PPA.S152146
PMCID: PMC5865580
PMID: 29593383
Rashid MA(1), Llanwarne N(2), Heyns N(2), Walter F(2), Mant J(2).
Author information:
(1)UCL Medical School, Royal Free Hospital, Hampstead, London, United Kingdom.
(2)Primary Care Unit, Department of Public Health & Primary Care, University of
Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom.
DOI: 10.1371/journal.pone.0195076
PMCID: PMC5955529
PMID: 29768417 [Indexed for MEDLINE]
Author information:
(1)Systems Biomedical Informatics Research Center, College of Nursing, Seoul
National University, Seoul, Republic Of Korea.
BACKGROUND: Hypertension is a chronic and lifestyle-related disease that requires
continuous preventive care. Although there are many evidence-based clinical
practice guidelines (CPGs) for hypertension management, applying them to daily
management can be difficult for patients with hypertension. A mobile app, based
on CPGs, could help patients with hypertension manage their disease.
OBJECTIVE: To develop a mobile app for hypertension management based on CPGs and
evaluate its effectiveness in patients with hypertension with respect to
perceived usefulness, user satisfaction, and medication adherence.
METHODS: The hypertension management app (HMA) was developed according to the
Web-Roadmap methodology, which includes planning, analysis, design,
implementation, and evaluation phases. The HMA was provided to individuals (N=38)
with hypertension. Medication adherence was measured before and after using the
HMA for 4 weeks. The perceived usefulness and user satisfaction were surveyed in
the patients who completed the medication adherence survey.
RESULTS: Of the 38 study participants, 29 (76%) participated in medical adherence
assessment. Medication adherence, as measured by the Modified Morisky Scale, was
significantly improved in these patients after they had used the HMA (P=.001).
The perceived usefulness score was 3.7 out of 5. The user satisfaction scores,
with respect to using the HMA for blood pressure recording, medication recording,
data sending, alerting, recommending, and educating about medication were 4.3,
3.8, 3.1, 3.2, 3.4, and 3.8 out of 5, respectively, in the 19 patients.
CONCLUSIONS: This study showed that a mobile app for hypertension management
based on CPGs is effective at improving medication adherence.
DOI: 10.2196/mhealth.4966
PMCID: PMC4756253
PMID: 26839283
967. Dig Dis Sci. 2017 Feb;62(2):543-549. doi: 10.1007/s10620-016-4391-z. Epub 2016
Dec 8.
Author information:
(1)Division of Gastroenterology/Hepatology, Department of Medicine, University of
California, San Francisco, 513 Parnassus Ave, Med Sci, San Francisco, CA, 94143,
USA.
(2)Division of Gastroenterology/Hepatology, Department of Medicine, University of
California, San Francisco, 513 Parnassus Ave, Med Sci, San Francisco, CA, 94143,
USA. Jennifer.lai@ucsf.edu.
DOI: 10.1007/s10620-016-4391-z
PMCID: PMC5263169
PMID: 27933471 [Indexed for MEDLINE]
Author information:
(1)Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of
Medical Sciences, Tehran, Iran;
(2)Department of Cardiology, Shariati Hospital, Tehran University of Medical
Sciences, Tehran, Iran;
(3)Research Center for Rational Use of Drugs, Tehran University of Medical
Sciences, Tehran, Iran;
(4)Department of Health Management and Economics, School of Public Health, Tehran
University of Medical Sciences, Tehran, Iran; Knowledge Utilization Research
Center, Tehran University of Medical Sciences, Tehran, Iran.
(5)Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of
Medical Sciences, Tehran, Iran; Research Center for Rational Use of Drugs, Tehran
University of Medical Sciences, Tehran, Iran;
(6)Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of
Medical Sciences, Tehran, Iran; Research Center for Rational Use of Drugs, Tehran
University of Medical Sciences, Tehran, Iran; khgholami@tums.ac.ir.
DOI: 10.1093/ajh/hpu062
PMCID: PMC4263942
PMID: 24771706 [Indexed for MEDLINE]
Identifying Brief Message Content for Interventions Delivered via Mobile Devices
to Improve Medication Adherence in People With Type 2 Diabetes Mellitus: A Rapid
Systematic Review.
Author information:
(1)Manchester Centre for Health Psychology, School of Health Sciences, University
of Manchester, Manchester, United Kingdom.
(2)Nuffield Department of Primary Care Health Sciences, University of Oxford,
Oxford, United Kingdom.
DOI: 10.2196/10421
PMCID: PMC6329430
PMID: 30626562
970. Int J Clin Pract. 2019 Jan;73(1):e13260. doi: 10.1111/ijcp.13260. Epub 2018
Sep
21.
Establishing US norms for the Adult ADHD Self-Report Scale (ASRS-v1.1) and
characterising symptom burden among adults with self-reported ADHD.
Adler LA(1), Faraone SV(2), Sarocco P(3), Atkins N(3), Khachatryan A(3).
Author information:
(1)Departments of Psychiatry and Child and Adolescent Psychiatry, NYU School of
Medicine, New York City, New York.
(2)Department of Psychiatry, SUNY Upstate Medical University, Syracuse, New York.
(3)Global Health Economics and Outcomes Research, Shire, LLC, Cambridge,
Massachusetts.
DOI: 10.1111/ijcp.13260
PMCID: PMC6585602
PMID: 30239073 [Indexed for MEDLINE]
Lucke T(1)(2), Herrera R(1)(3), Wacker M(4), Holle R(4), Biertz F(5), Nowak
D(1)(2), Huber RM(2)(6), Söhler S(7), Vogelmeier C(7), Ficker JH(8)(9), Mückter
H(10), Jörres RA(1)(2); COSYCONET-Consortium.
Author information:
(1)Institute and Outpatient Clinic for Occupational, Social and Environmental
Medicine, University Hospital LMU Munich, München, Germany.
(2)Comprehensive Pneumology Center Munich, DZL, German Center for Lung Research,
München, Germany.
(3)Center for International Health, Ludwig-Maximilian University Munich, München,
Germany.
(4)German Research Center for Environmental Health, Institute of Health Economics
and Health Care Management, Member of the German Center for Lung Research,
Comprehensive Pneumology Center Munich (CPC-M), Neuherberg, Germany.
(5)Institute for Biostatistics, Hannover Medical School, Hannover, Germany.
(6)Thoracic Oncology Center Munich (TOM), University Hospital LMU Munich,
München, Germany.
(7)Pulmonary and Critical Care Medicine, Department of Medicine, University
Medical Centre Giessen and Marburg, Philipps-University, Marburg, Germany.
(8)Department of Respiratory Medicine, Allergology and Sleep Medicine, Klinikum
Nuremberg, Nürnberg, Germany.
(9)Paracelsus Medical University Nuremberg, Nürnberg, Germany.
(10)Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilian
University Munich, München, Germany.
DOI: 10.1371/journal.pone.0163408
PMCID: PMC5085029
PMID: 27792735 [Indexed for MEDLINE]
Kidney transplant recipients' attitudes about using mobile health technology for
managing and monitoring medication therapy.
DOI: 10.1016/j.japh.2016.03.017
PMCID: PMC4968877
PMID: 27450140 [Indexed for MEDLINE]
Author information:
(1)1 Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta,
Edmonton, Alberta, Canada.
(2)2 Grey Nuns Community Hospital, Edmonton, Alberta, Canada.
DOI: 10.18553/jmcp.2017.23.5.566
PMID: 28448775 [Indexed for MEDLINE]
Author information:
(1)Partners Healthcare Center for Connected Health, Boston, MA, United States.
sagboola@partners.org.
BACKGROUND: The widespread and increasing use of oral anti-cancer medications has
been ushered in by a rapidly increasing understanding of cancer pathophysiology.
Furthermore, their popular ease of administration and potential cost savings has
highlighted their central position in the health care system as a whole. These
facts have heightened appreciation of the unique challenges associated with the
use of oral anti-cancer medications; especially in the long-term use of these
medications and the associated side effects that may impede optimal adherence to
their use. Therefore, we developed ChemOtheRapy Assistant, CORA, a personalized
mobile phone-based self-management application to help cancer patients on oral
anti-cancer medications.
OBJECTIVE: Our objective is to evaluate the effect of CORA on adherence to oral
anti-cancer medications and other clinically relevant outcomes in the management
of patients with renal and prostate cancer.
METHODS: The study will be implemented as a 2-parallel group randomized
controlled trial in 104 patients with renal or prostate cancer on oral
anti-cancer medications over a 3-month study period. The intervention group will
use CORA in addition to usual care for self-management while the control group
will continue care as usual. Medication adherence will be measured objectively by
a Medication Event Monitoring System device and is defined as the percentage of
prescribed doses taken. We will also assess the effect of the intervention on
cancer-related symptoms measured by the MD Anderson Symptom Inventory and
unplanned hospital utilizations. Other outcomes that will be measured at study
start, midpoint, and endpoint are health-related quality of life, cancer-related
fatigue, and anxiety. Group differences in medication adherence will be examined
by t tests or by non-parametric Mann-Whitney tests if the data are not normally
distributed. Logistic regression will be used to identify potential predictors of
adherence.
RESULTS: We expect to have results for this study before the end of 2016.
CONCLUSIONS: This novel mobile phone-enabled, multimodal self-management and
educational intervention could lead to improvements in clinical outcomes and
serve as a foundation for future mHealth research in improving outcomes for
patients on oral anti-cancer medications.
DOI: 10.2196/resprot.4041
PMCID: PMC4296099
PMID: 25537463
Author information:
(1)Clinical BioPharmaceutics Research Group (CBRG), Faculty of Pharmacy,
Universiti Teknologi MARA , Puncak Alam Campus, 42300 Bandar Puncak Alam,
Selangor, Malaysia .
(2)Faculty of Pharmacy, Level 9, Pharmacy Building, MAHSA University , Jalan SP2,
Bandar Saujana Putra, 42610 Jenjarom, Kuala Langat, Selangor, Malaysia .
(3)Endocrine Unit, Medical Department, Hospital Kuala Lumpur , 50586 Jalan
Pahang, Kuala Lumpur, Malaysia .
INTRODUCTION: The Diabetes Mellitus (DM) is a common silent epidemic disease with
frequent morbidity and mortality. The psychological and psychosocial health
factors are negatively influencing the glycaemic control in diabetic patients.
Therefore, various questionnaires were developed to address the psychological and
psychosocial well-being of the diabetic patients. Most of these questionnaires
were first developed in English and then translated into different languages to
make them useful for the local communities.
AIM: The main aim of this study was to translate and validate the Malaysian
versions of Perceived Diabetes Self-Management Scale (PDSMS), Medication
Understanding and Use Self-Efficacy Scale (MUSE), and to revalidate 8-Morisky
Medication Adherence Scale (MMAS-8) by Partial Credit Rasch Model (Modern Test
Theory).
MATERIALS AND METHODS: Permission was obtained from respective authors to
translate the English versions of PDSMS, MUSE and MMAS-8 into Malay language
according to established standard international translation guidelines. In this
cross-sectional study, 62 adult DM patients were recruited from Hospital Kuala
Lumpur by purposive sampling method. The data were extracted from the
self-administered questionnaires and entered manually in the Ministeps (Winsteps)
software for Partial Credit Rasch Model. The item and person reliability,
infit/outfit Z-Standard (ZSTD), infit/outfit Mean Square (MNSQ) and point measure
correlation (PTMEA Corr) values were analysed for the reliability analyses and
construct validation.
RESULTS: The Malay version of PDSMS, MUSE and MMAS-8 found to be valid and
reliable instrument for the Malaysian diabetic adults. The instrument showed good
overall reliability value of 0.76 and 0.93 for item and person reliability,
respectively. The values of infit/outfit ZSTD, infit/outfit MNSQ, and PTMEA Corr
were also within the stipulated range of the Rasch Model proving the valid item
constructs of the questionnaire.
CONCLUSION: The translated Malay version of PDSMS, MUSE and MMAS-8 was found to
be a highly reliable and valid questionnaire by Partial Credit Model. The Malay
version was conceptually equivalent to original version, easy to understand and
can be used for the Malaysian adult diabetic patients for future studies.
DOI: 10.7860/JCDR/2016/15079.8845
PMCID: PMC5198358
PMID: 28050405
Author information:
(1)Department of Psychiatry, Far Eastern Memorial Hospital, New Taipei City,
Taiwan; College of Public Health, National Taiwan University, Taipei, Taiwan;
Department of Psychiatry, National Taiwan University Hospital and College of
Medicine, National Taiwan University, Taipei, Taiwan.
(2)College of Public Health, National Taiwan University, Taipei, Taiwan.
(3)College of Public Health, National Taiwan University, Taipei, Taiwan;
Department of Psychiatry, National Taiwan University Hospital and College of
Medicine, National Taiwan University, Taipei, Taiwan.
(4)Center of Neuropsychiatric Research, National Health Research Institutes,
Zhunan, Taiwan.
(5)Division of Biostatistics and Bioinformatics, Institute of Population Health
Sciences, National Health Research Institutes, Zhunan, Taiwan; Department of
Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung,
Taiwan; Department of Pediatrics, Feinberg School of Medicine, Northwestern
University, Chicago, Illinois, United States of America.
PURPOSE: The aim of this study was to evaluate the concordance between claims
records in the National Health Insurance Research Database and patient
self-reports on clinical diagnoses, medication use, and health system
utilization.
METHODS: In this study, we used the data of 15,574 participants collected from
the 2005 Taiwan National Health Interview Survey. We assessed positive agreement,
negative agreement, and Cohen's kappa statistics to examine the concordance
between claims records and patient self-reports.
RESULTS: Kappa values were 0.43, 0.64, and 0.61 for clinical diagnoses,
medication use, and health system utilization, respectively. Using a strict
algorithm to identify the clinical diagnoses recorded in claims records could
improve the negative agreement; however, the effect on positive agreement and
kappa was diverse across various conditions.
CONCLUSION: We found that the overall concordance between claims records in the
National Health Insurance Research Database and patient self-reports in the
Taiwan National Health Interview Survey was moderate for clinical diagnosis and
substantial for both medication use and health system utilization.
DOI: 10.1371/journal.pone.0112257
PMCID: PMC4251897
PMID: 25464005 [Indexed for MEDLINE]
Author information:
(1)Final Year Student, Department of Ophthalmology, Glaucoma Service, Government
Medical College and Hospital, Chandigarh, India.
(2)Assistant Professor, Department of Ophthalmology, Glaucoma Service, Government
Medical College and Hospital, Chandigarh, India.
(3)Associate Professor, Department of Ophthalmology, Glaucoma Service, Government
Medical College and Hospital, Chandigarh, India.
DOI: 10.5005/jp-journals-10008-1181
PMCID: PMC4750024
PMID: 26997832
978. Pediatr Rheumatol Online J. 2016 Oct 19;14(1):57.
McDonagh JE(1), Shaw KL(2), Prescott J(3), Smith FJ(4), Roberts R(5), Gray NJ(6).
Author information:
(1)Centre for Musculoskeletal Research, Stopford Building, University of
Manchester, Oxford Rd, Manchester, England, M13 9PT, UK.
janet.mcdonagh@manchester.ac.uk.
(2)NIHR CLAHRC West Midlands, University of Birmingham, Birmingham, UK.
(3)School of Education and Psychology, University of Bolton, Bolton, England, UK.
(4)UCL School of Pharmacy, London, England, UK.
(5)Pharmacy Research UK, London, England, UK.
(6)Green Line Consulting Limited, Manchester, England, UK.
DOI: 10.1186/s12969-016-0117-1
PMCID: PMC5070126
PMID: 27756328 [Indexed for MEDLINE]
Chang AC, Lincoln J, Lantaff WM, Gernant SA, Jaynes HA, Doucette W, Snyder ME.
Erratum in
J Am Pharm Assoc (2003). 2018 Mar 29;:.
DOI: 10.1016/j.japh.2017.09.059
PMCID: PMC5748350
PMID: 29129668 [Indexed for MEDLINE]
980. Can J Hosp Pharm. 2017 Jul-Aug;70(4):263-269. Epub 2017 Aug 31.
MacDonald N(1), Manuel L(2), Brennan H(3), Musgrave E(4), Wanbon R(5), Stoica
G(6).
Author information:
(1), BSc(Pharm), ACPR, is with the Health Sciences Centre, Eastern Health, St
John's, Newfoundland and Labrador.
(2), BSc(Chem), BSc(Pharm), PharmD, ACPR, is with Horizon Health Network - The
Moncton Hospital, Moncton, New Brunswick.
(3), BSc(Pharm), ACPR, is with Horizon Health Network - The Moncton Hospital,
Moncton, New Brunswick.
(4), MN, RN, ENC(C), is with Horizon Health Network - The Moncton Hospital,
Moncton, New Brunswick.
(5), BSc(Pharm), ACPR, PharmD, is with Vancouver Island Health Authority - Royal
Jubilee Hospital, Victoria, British Columbia.
(6), PhD (Statistics), PhD (Mathematics), is with Horizon Health Network - Saint
John Regional Hospital, Saint John, New Brunswick.
BACKGROUND: Accreditation standards have outlined the need for staff in emergency
departments to initiate the medication reconciliation process for patients who
are at risk of adverse drug events. The authors hypothesized that a guided form
could be used by non-admitted patients in the emergency department to assist with
completion of a best possible medication history (BPMH).
OBJECTIVE: To determine the percentage of patients in the non-acute care area of
the emergency department who could complete a guided BPMH form with no clinically
significant discrepancies (defined as no major discrepancies and no more than 1
moderate discrepancy).
METHODS: This prospective exploratory study was conducted over 4 weeks in
February and March 2016. Data were collected using the self-administered BPMH
form, patient interviews, and a data collection form. After completion of the
guided BPMH form, patients were randomly selected for interview by a pharmacy
team member to ensure their self-completed BPMH forms were complete and accurate.
Eligible patients were those with non-acute needs who had undergone triage to the
waiting room. Patients who were already admitted and those with immediate triage
to the acute care or trauma area of the emergency department were excluded.
RESULTS: Of the 160 patients who were interviewed, 146 (91.3%) completed the form
with no more than 1 moderate discrepancy (but some number of minor
discrepancies). There were no discrepancies in 31 (19.4%) of the BPMH forms, and
101 (63.1%) of the forms had only minor discrepancies.
CONCLUSIONS: Most of the patients interviewed by the pharmacy team were able to
complete the BPMH form with no clinically significant discrepancies. The
self-administered BPMH form would be a useful tool to initiate medication
reconciliation in the emergency department for this patient population, but used
on its own, it would not be a reliable source of BPMH information, given the
relatively low number of patients who completed the form with no discrepancies.
Publisher: Les normes d’agrément ont souligné la nécessité pour le personnel des
services des urgences d’amorcer le processus de bilan comparatif des médicaments
chez les patients à risque d’événements indésirables liés aux médicaments. Les
auteurs ont avancé que des patients au service des urgences ne requérant pas une
hospitalisation pourraient remplir un formulaire dirigé et ainsi aider à établir
leur meilleur schéma thérapeutique possible (MSTP).Déterminer le pourcentage de
patients dans l’aire de soins non urgents du service des urgences qui sont en
mesure de remplir un formulaire dirigé de MSTP sans divergence cliniquement
significative (c’est-à-dire aucune divergence majeure et pas plus d’une
divergence modérée).La présente étude préliminaire prospective a été menée sur
une période de quatre semaines en février et en mars 2016. Les données ont été
recueillies à l’aide d’un formulaire autoadministré de MSTP, d’entrevue avec les
patients et d’un formulaire de collecte de données. Une fois les formulaires
dirigés de MSTP remplis, des patients ont été sélectionnés aléatoirement et
interrogés par un des membres de l’équipe de pharmacie afin de s’assurer de
l’exhaustivité et de l’exactitude des renseignements fournis de soi-même. Les
patients admissibles à l’étude étaient ceux ne nécessitant pas de soins urgents
et ayant passé au triage dans la salle d’attente. Les patients déjà hospitalisés
et ceux dirigés immédiatement après le triage dans l’aire de soins urgents ou de
trauma du service des urgences ont été exclus.Parmi les 160 patients interrogés,
146 (91,3 %) avaient rempli le formulaire avec au plus une divergence modérée
(mais un certain nombre de divergences mineures). Dans 31 (19,4 %) des
formulaires de MSTP, il n’y avait aucune divergence et, dans 101 (63,1 %) des
formulaires, il n’y avait que des divergences mineures.La plupart des patients
interrogés par l’équipe de pharmacie étaient en mesure de remplir le formulaire
de MSTP sans qu’apparaisse de divergence cliniquement significative. Le
formulaire autoadministré de MSTP serait un outil pratique pour établir un bilan
comparatif des médicaments dans le service des urgences pour cette population de
patients, mais employé seul, il ne représenterait pas une source fiable
d’information sur le MSTP, compte tenu du nombre relativement restreint de
patients ayant rempli le formulaire sans qu’apparaisse de divergence.
DOI: 10.4212/cjhp.v70i4.1675
PMCID: PMC5587038
PMID: 28894309
Author information:
(1)Department of Medicine, University of California, UCSF Box 0886, 50 Beale St.,
Suite 1300, San Francisco, CA, 94105, USA, parya.saberi@ucsf.edu.
DOI: 10.1007/s10461-014-0806-z
PMCID: PMC4250439
PMID: 24879628 [Indexed for MEDLINE]
Bouwman L(1), Eeltink CM(2)(3), Visser O(1), Janssen JJWM(1), Maaskant JM(4)(5).
Author information:
(1)Department of Hematology, VU University Medical Center, Amsterdam, the
Netherlands.
(2)Department of Hematology, VU University Medical Center, Amsterdam, the
Netherlands. c.eeltink@vumc.nl.
(3)Cancer Center Amsterdam, VU University Medical Center, De Boelelaan 1117,
1081, HV, Amsterdam, The Netherlands. c.eeltink@vumc.nl.
(4)Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands.
(5)Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Medical
Faculty, Academic Medical Center and University of Amsterdam, Amsterdam, the
Netherlands.
DOI: 10.1186/s12885-017-3735-1
PMCID: PMC5679497
PMID: 29121889 [Indexed for MEDLINE]
Hein KT(1), Maung TM(2), Htet KKK(2), Shewade HD(3)(4), Tripathy JP(3)(4), Oo
SM(5), Lin Z(6), Thi A(7).
Author information:
(1)Department of Medical Research, Ministry of Health and Sports, Yangon,
Myanmar. hein.z.ze@gmail.com.
(2)Department of Medical Research, Ministry of Health and Sports, Yangon,
Myanmar.
(3)International Union Against Tuberculosis and Lung Disease (The Union),
South-East Asia Office, New Delhi, India.
(4)International Union Against Tuberculosis and Lung Disease (The Union), Paris,
France.
(5)Population Services International, Yangon, Myanmar.
(6)Vector Borne Disease Control Program, Ministry of Health and Sports, Nay Pyi
Taw, Myanmar.
(7)National Malaria Control Program, Ministry of Health and Sports, Nay Pyi Taw,
Myanmar.
DOI: 10.1186/s12936-018-2546-4
PMCID: PMC6206677
PMID: 30373591 [Indexed for MEDLINE]
Tuberculosis treatment delays and associated factors within the Zimbabwe national
tuberculosis programme.
Author information:
(1)AIDS and TB Department, Zimbabwe Ministry of Health and Child Care, P. O Box
CY 1122, Causeway, Harare, Zimbabwe. ktakarinda@theunion.org.
(2)International Union Against Tuberculosis and Lung Disease, Paris, France.
ktakarinda@theunion.org.
(3)International Union Against Tuberculosis and Lung Disease, Paris, France.
adharries@theunion.org.
(4)Department of Clinical Research, London School of Hygiene and Tropical
Medicine, London, UK. adharries@theunion.org.
(5)TB CARE Project, International Union Against Tuberculosis and Lung Disease,
Harare, Zimbabwe. bnyathi@mweb.co.zw.
(6)AIDS and TB Department, Zimbabwe Ministry of Health and Child Care, P. O Box
CY 1122, Causeway, Harare, Zimbabwe. mkhongwenya@gmail.com.
(7)AIDS and TB Department, Zimbabwe Ministry of Health and Child Care, P. O Box
CY 1122, Causeway, Harare, Zimbabwe. tsitsiapollo@gmail.com.
(8)AIDS and TB Department, Zimbabwe Ministry of Health and Child Care, P. O Box
CY 1122, Causeway, Harare, Zimbabwe. dr.c.sandy@gmail.com.
DOI: 10.1186/s12889-015-1437-7
PMCID: PMC4314739
PMID: 25631667 [Indexed for MEDLINE]
Author information:
(1)Department of Psychology, Università Cattolica del Sacro Cuore, Milan, Italy.
(2)Department of Statistical Sciences, Università Cattolica del Sacro Cuore,
Milan, Italy.
DOI: 10.1371/journal.pone.0179865
PMCID: PMC5487073
PMID: 28654686 [Indexed for MEDLINE]
Holstad MM(1), Spangler S(2), Higgins M(2), Dalmida SG(2), Sharma S(3).
Author information:
(1)Nell Hodgson Woodruff School of Nursing, Emory University, 1520 Clifton Road,
Atlanta, GA, USA. nurmmcd@emory.edu.
(2)Nell Hodgson Woodruff School of Nursing, Emory University, 1520 Clifton Road,
Atlanta, GA, USA.
(3)School of Medicine, Emory University, 1520 Clifton Road, Atlanta, GA, USA.
DOI: 10.1007/s10461-015-1209-5
PMCID: PMC4826632
PMID: 26452670 [Indexed for MEDLINE]
987. Respir Care. 2015 May;60(5):744-8. doi: 10.4187/respcare.04088. Epub 2015 Apr
14.
Deakins KM(1).
Author information:
(1)Pediatric Respiratory Care Department, University Hospitals Rainbow Babies and
Children's Hospital, Cleveland, Ohio. kathleen.deakins@uhhospitals.org.
DOI: 10.4187/respcare.04088
PMID: 25873743 [Indexed for MEDLINE]
Author information:
(1)School of Pharmacy, University of Queensland, Brisbane, Queensland, Australia.
(2)Pharmacy Department, Princess Alexandra Hospital, Brisbane, Queensland,
Australia.
(3)School of Pharmacy and Medical Sciences, University of South Australia,
Adelaide, South Australia, Australia.
(4)DATIS, Southern Adelaide Local Health Network, Flinders Medical Centre,
Adelaide, South Australia, Australia.
(5)Norwich Medical School, University of East Anglia, Norwich, UK.
DOI: 10.1136/bmjopen-2018-022225
PMCID: PMC6119418
PMID: 30166304
Mefford M(1), Safford MM(2), Muntner P(1), Durant RW(3), Brown TM(4), Levitan
EB(5).
Author information:
(1)Department of Epidemiology, University of Alabama at Birmingham, Birmingham,
AL, USA.
(2)Department of Internal Medicine, Weill Cornell Medicine, Cornell University,
New York, NY, USA.
(3)Division of Preventive Medicine, School of Medicine, University of Alabama at
Birmingham, Birmingham, AL, USA.
(4)Division of Cardiovascular Disease, School of Medicine, University of Alabama
at Birmingham, Birmingham, AL, USA.
(5)Department of Epidemiology, University of Alabama at Birmingham, Birmingham,
AL, USA. Electronic address: elevitan@uab.edu.
DOI: 10.1016/j.ijcard.2017.02.105
PMCID: PMC5411175
PMID: 28259549 [Indexed for MEDLINE]
Win AYN(1)(2), Maung TM(3), Wai KT(4), Oo T(4), Thi A(5), Tipmontree R(6),
Soonthornworasiri N(1), Kengganpanich M(7), Kaewkungwal J(8).
Author information:
(1)Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol
University, Bangkok, Thailand.
(2)Epidemiology Research Division, Department of Medical Research, No. 5 Ziwaka
Road, Yangon, Myanmar.
(3)Medical Statistics Division, Department of Medical Research, No. 5 Ziwaka
Road, Yangon, Myanmar.
(4)Department of Medical Research, No. 5 Ziwaka Road, Yangon, Myanmar.
(5)National Malaria Control Programme, Department of Public Health, NayPyiTaw,
Myanmar.
(6)Bureau of Vector Borne Diseases, Department of Disease Control, Ministry of
Public Health, Bangkok, Thailand.
(7)Department of Health Education and Behavior Sciences, Faculty of Public
Health, Mahidol University, Bangkok, Thailand.
(8)Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol
University, Bangkok, Thailand. jaranitk@biophics.org.
DOI: 10.1186/s12936-017-2113-4
PMCID: PMC5683526
PMID: 29132373 [Indexed for MEDLINE]
Prescription medicine use by pedestrians and the risk of injurious road traffic
crashes: A case-crossover study.
Née M(1)(2), Avalos M(1)(3), Luxcey A(1)(2), Contrand B(1)(2), Salmi LR(1)(2)(4),
Fourrier-Réglat A(5)(6)(7), Gadegbeku B(8)(9)(10), Lagarde E(1)(2), Orriols
L(1)(2).
Author information:
(1)Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED),
Université de Bordeaux, Bordeaux, France.
(2)Team IETO, Bordeaux Population Health Research Center, UMR U1219, INSERM,
Université de Bordeaux, Bordeaux, France.
(3)Team Biostatistique, Bordeaux Population Health Research Center, UMR U1219,
INSERM, Université Bordeaux, Bordeaux, France.
(4)Service d'Information Médicale, Pôle de Santé Publique, Centre Hospitalier
Universitaire de Bordeaux, Bordeaux, France.
(5)Team Pharmacoepidemiology, Bordeaux Population Health Research Center, UMR
U1219, INSERM, Université Bordeaux, Bordeaux, France.
(6)Pharmacologie Medicale, Pôle de Santé Publique, Centre Hospitalier
Universitaire de Bordeaux, Bordeaux, France.
(7)Centre d'Investigation Clinique Bordeaux, INSERM CIC 1401, Centre Hospitalier
Universitaire de Bordeaux, Bordeaux, France.
(8)Université de Lyon, Lyon, France.
(9)UMRESTTE, UMR T9405, l'Institut Français des Sciences et Technologies des
Transports, de l'Aménagement et des Réseaux (IFSTTAR), Bron, France.
(10)UMRESTTE, Université Lyon 1, Lyon, France.
BACKGROUND: While some medicinal drugs have been found to affect driving ability,
no study has investigated whether a relationship exists between these medicines
and crashes involving pedestrians. The aim of this study was to explore the
association between the use of medicinal drugs and the risk of being involved in
a road traffic crash as a pedestrian.
METHODS AND FINDINGS: Data from 3 French nationwide databases were matched. We
used the case-crossover design to control for time-invariant factors by using
each case as its own control. To perform multivariable analysis and limit
false-positive results, we implemented a bootstrap version of Lasso. To avoid the
effect of unmeasured time-varying factors, we varied the length of the washout
period from 30 to 119 days before the crash. The matching procedure led to the
inclusion of 16,458 pedestrians involved in an injurious road traffic crash from
1 July 2005 to 31 December 2011. We found 48 medicine classes with a positive
association with the risk of crash, with median odds ratios ranging from 1.12 to
2.98. Among these, benzodiazepines and benzodiazepine-related drugs,
antihistamines, and anti-inflammatory and antirheumatic drugs were among the 10
medicines most consumed by the 16,458 pedestrians. Study limitations included
slight overrepresentation of pedestrians injured in more severe crashes, lack of
information about self-medication and the use of over-the-counter drugs, and lack
of data on amount of walking.
CONCLUSIONS: Therapeutic classes already identified as impacting the ability to
drive, such as benzodiazepines and antihistamines, are also associated with an
increased risk of pedestrians being involved in a road traffic crash. This study
on pedestrians highlights the necessity of improving awareness of the effect of
these medicines on this category of road user.
DOI: 10.1371/journal.pmed.1002347
PMCID: PMC5515401
PMID: 28719606 [Indexed for MEDLINE]
Using the Medication Adherence Reasons Scale (MAR-Scale) to identify the reasons
for non-adherence across multiple disease conditions.
Author information:
(1)College of Pharmacy, Roseman University of Health Sciences, South Jordan, UT,
USA.
(2)Kantar Health , New York, NY, USA.
Purpose: With more than 50% of the individuals on chronic conditions not taking
medicines as prescribed, it is essential for health care providers to understand
the reasons, so that adherence-related conversations can be initiated and focused
appropriately. Measuring medication non-adherence is complex, because patients
are often on multiple medications and take them via various modes of
administration such as orally, by injection, or topically, and at various
frequencies such as daily or weekly. The Medication Adherence Reasons Scale
(MAR-Scale) is a twenty-item, self-reported, comprehensive scale developed to
measure two aspects of medication non-adherence: the extent or frequency of
non-adherence and reasons for non-adherence. The objective of this study was to
identify the top reasons, in 17 distinct chronic disease conditions, reported by
patients for being non-adherent across various modes and frequencies of the
corresponding medications. Internal reliability of the MAR-Scale was also
assessed in each condition. Patients and methods: Results were derived from
Kantar Health's US 2017 National Health and Wellness Survey (NHWS), a
self-administered, annual, Internet-based cross-sectional survey of 75,000 adults
(≥18 years). The survey sample was drawn from an Internet panel and was
stratified according to age, gender, and ethnicity in order to represent the US
adult population based on the US Census Bureau. Respondents to the 2017 NHWS who
self-reported taking prescription medication(s) to treat one of the 17 conditions
were invited to complete the MAR-Scale in a follow-up online survey, reporting on
reasons for non-adherence in the past 7 days (daily medications) or four weeks
(weekly), with non-adherence defined as any reported non-adherence in the
corresponding timeframe for medicines taken orally, by injection, and topically.
Results: MAR-Scale data were obtained from 15,672 respondents in one or more
conditions, modes, and frequencies. MAR-Scale reliability ranged from Cronbach's
alpha of 0.861 in multiple sclerosis to 0.973 in psoriasis. For daily orals,
non-adherence ranged from 25.2% in diabetes to 63.7% in eczema. The most common
reasons across conditions were "simply missed it," "side effects," and "concern
about long-term effects." Conclusion: The MAR-Scale demonstrates acceptable
reliability in multiple chronic disease conditions and across modes and
frequencies of administration.
DOI: 10.2147/PPA.S205359
PMCID: PMC6612984
PMID: 31308635
Conflict of interest statement: At the time of the study, Amir Goren and
Nikoletta Sternbach were employees of Kantar Health, which provided funding and
support for fielding the current version of the MAR-Scale. The authors report no
other conflicts of interest in this work.
Basu S(1), Garg S(2), Sharma N(2), Singh MM(2), Garg S(3).
Author information:
(1)Department of Community Medicine, Maulana Azad Medical College, New Delhi
110002, India. saurav.basu.mph@gmail.com.
(2)Department of Community Medicine, Maulana Azad Medical College, New Delhi
110002, India.
(3)Department of Medicine, Maulana Azad Medical College, New Delhi 110002, India.
DOI: 10.4239/wjd.v9.i5.72
PMCID: PMC6033702
PMID: 29988911
994. Clin Exp Rheumatol. 2015 Mar-Apr;33(2 Suppl 89):S-185-6. Epub 2015 May 26.
The relationship between peer support, medication adherence, and quality of life
among patients with vasculitis.
Alexander DS(1), Hogan SL(2), Jordan JM(3), DeVellis RF(3), Carpenter DM(1).
Author information:
(1)University of North Carolina at Chapel Hill, UNC Eshelman School of Pharmacy,
Division of Pharmaceutical Outcomes and Policy, Asheville, NC, USA.
(2)UNC Kidney Center, University of North Carolina, Chapel Hill, NC, USA.
(3)Thurston Arthritis Research Center, University of North Carolina, Chapel Hill,
NC, USA.
PMCID: PMC4879819
PMID: 26016771 [Indexed for MEDLINE]
Author information:
(1)West China School of Nursing and Department of Nursing, West China Hospital,
Sichuan University, Chengdu, China, 1366109878@qq.com.
Purpose: The aim of this study was to determine the prevalence and predictors of
medication nonadherence among patients with systemic lupus erythematosus (SLE) in
Sichuan.
Patients and methods: A cross-sectional investigation was performed. Participants
were recruited by consecutive sampling from the Rheumatic Clinic of a university
hospital between June and September 2016. Patients' self-reported medication
adherence was assessed by the eight-item Morisky Medication Adherence Scale.
Additional surveys included patients' demographics, and clinical and treatment
characteristics. Logistic regression analysis was used to identify the predictors
of medication nonadherence.
Results: A total of 140 patients were included in analysis. The percentage of
patients classified as nonadherent to medication was 75%. Low education, rural
residency, childlessness, limited comprehension of medication instructions, side
effects experienced, dissatisfaction with treatment and better physical health
were associated with an increased risk of nonadherence.
Conclusion: This study demonstrated a high prevalence of medication nonadherence
among SLE patients in Sichuan, and factors associated with the nonadherence are
multifaceted. Interventions for these factors, such as appropriate adjustment of
the service resources for patients with rheumatic disease in rural communities
and improved communication between the health care providers and the patients,
may contribute to improve the medication adherence of this cohort.
DOI: 10.2147/PPA.S169776
PMCID: PMC6112788
PMID: 30197502
Author information:
(1)Department of Alice Lee Centre for Nursing Studies, Yong Loo Lin School of
Medicine, National University of Singapore, Singapore.
(2)Faculty of Social Sciences and Humanities, the University of Macau, Macau
Special Administration Region, China.
Erratum in
PLoS One. 2018 Sep 17;13(9):e0204440.
DOI: 10.1371/journal.pone.0196774
PMCID: PMC5967800
PMID: 29795563 [Indexed for MEDLINE]
Author information:
(1)Faculty of Professional Studies, University of Nordland, Campus Helgeland,
Postboks 614, N-8607 Mo i Rana, Norway. Johanne.Alteren@uin.no.
(2)Faculty of Professional Studies, University of Nordland, Campus Helgeland,
Postboks 614, N-8607 Mo i Rana, Norway. Lisbeth.Nerdal@uin.no.
DOI: 10.3390/healthcare3020351
PMCID: PMC4939530
PMID: 27417767
Author information:
(1)McCoy College of Business Administration, Department of Computer Information
Systems and Quantitative Methods, Texas State University, San Marcos, TX, United
States. jl38@txstate.edu.
DOI: 10.2196/ijmr.5462
PMCID: PMC4904823
PMID: 27185210
999. LGBT Health. 2017 Jun;4(3):181-187. doi: 10.1089/lgbt.2017.0003. Epub 2017 May
12.
Author information:
(1)Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention ,
Atlanta, Georgia .
PURPOSE: We examined factors associated with antiretroviral therapy (ART)
adherence among transgender women living with HIV (TWLWH).
METHODS: We used combined data from the 2009 to 2013 cycles of Medical Monitoring
Project, an HIV surveillance system designed to produce nationally representative
estimates of the characteristics of HIV-infected adults receiving HIV medical
care in the United States. Rao-Scott chi-square tests and multivariable logistic
regression were used to identify factors associated with dose adherence (defined
as taking 100% of prescribed ART doses in the past 3 days).
RESULTS: Among TWLWH who reported current ART use, an estimated 80.5%
self-reported dose adherence. Multivariable factors independently associated with
lower (<100%) dose adherence were younger age (30-39 vs. 40 and over), not having
health insurance coverage, depression, lower self-efficacy to take medication as
prescribed, and having greater than one daily ART dose.
CONCLUSION: Our findings suggest several ways to potentially improve ART
adherence of TWLWH including tailoring efforts to address the needs of TWLWH
under age 40, increasing access to health insurance coverage, addressing mental
health morbidities, building skills to improve medication adherence
self-efficacy, and simplifying ART regimens when possible.
DOI: 10.1089/lgbt.2017.0003
PMCID: PMC6711391
PMID: 28498011 [Indexed for MEDLINE]
Author information:
(1)Department of Infectious Diseases and Clinical Virology, Karolinska University
Hospital, Stockholm, Sweden.
(2)Department of Public Health Sciences, Karolinska Institutet, Solna, Sweden.
(3)Clinic of Infectious Diseases, South Älvsborg Hospital, Borås, Sweden.
(4)Department of Learning, Informatics, Management and Ethics, Karolinska
Institutet, Solna, Sweden.
(5)Department of Infectious Diseases, Karolinska University Hospital, Stockholm,
Sweden.
(6)School of Health Sciences, City University London, London, United Kingdom.
(7)Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska
Institutet, Stockholm, Sweden.
DOI: 10.1371/journal.pone.0156916
PMCID: PMC4911158
PMID: 27310201 [Indexed for MEDLINE]
DOI: 10.1353/hpu.2017.0036
PMCID: PMC5492520
PMID: 28239015 [Indexed for MEDLINE]
Author information:
(1)Department of Immunology, Children's Hospital Research Institute of Manitoba,
University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada; and.
(2)Department of Immunology, Children's Hospital Research Institute of Manitoba,
University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada; and Department of
Pediatrics and Child Health, Children's Hospital Research Institute of Manitoba,
University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada.
(3)Department of Immunology, Children's Hospital Research Institute of Manitoba,
University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada; and Department of
Pediatrics and Child Health, Children's Hospital Research Institute of Manitoba,
University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada
kent.hayglass@umanitoba.ca.
DOI: 10.4049/jimmunol.1500460
PMID: 26895836 [Indexed for MEDLINE]
Author information:
(1)a Center for Clinical Epidemiology & Biostatistics (CCEB), Perelman School of
Medicine , University of Pennsylvania , Philadelphia , PA , USA.
DOI: 10.1080/09540121.2014.969676
PMCID: PMC4305494
PMID: 25338010 [Indexed for MEDLINE]
Author information:
(1)Sainte-Anne Hospital (SHU), Paris V-Descartes University, Paris, France.
(2)Hôpital Charles Perrens, Pôle de Psychiatrie Adulte, Bordeaux University,
Bordeaux, France ; CNRS UMR 5287-INCIA, Bordeaux University, Bordeaux, France.
(3)Janssen-Cilag France, Issy Les Moulineaux, Paris, France.
DOI: 10.2147/PPA.S89748
PMCID: PMC4577258
PMID: 26396505
1005. PLoS One. 2016 Oct 17;11(10):e0164704. doi: 10.1371/journal.pone.0164704.
eCollection 2016.
Quality of Diabetes Care in Germany Improved from 2000 to 2007 to 2014, but
Improvements Diminished since 2007. Evidence from the Population-Based KORA
Studies.
Laxy M(1)(2), Knoll G(1)(3), Schunk M(1), Meisinger C(2)(4), Huth C(2)(4), Holle
R(1)(2).
Author information:
(1)Institute of Health Economics and Health Care Management, Helmholtz Zentrum
München, Neuherberg, Germany.
(2)German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
(3)Institute for Medical Informatics, Biometrics and Epidemiology,
Ludwig-Maximilians- Universität München, Munich, Germany.
(4)Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany.
OBJECTIVE: Little is known about the development of the quality of diabetes care
in Germany. The aim of this study is to analyze time trends in patient
self-management, physician-delivered care, medication, risk factor control,
complications and quality of life from 2000 to 2014.
METHODS: Analyses are based on data from individuals with type 2 diabetes of the
population-based KORA S4 (1999-2001, n = 150), F4 (2006-2008, n = 203), FF4
(2013/14, n = 212) cohort study. Information on patient self-management,
physician-delivered care, medication, risk factor control and quality of life
were assessed in standardized questionnaires and examinations. The 10-year
coronary heart disease (CHD) risk was calculated using the UKPDS risk engine.
Time trends were analyzed using multivariable linear and logistic regression
models adjusted for age, sex, education, diabetes duration, and history of
cardiovascular disease.
RESULTS: From 2000 to 2014 the proportion of participants with type 2 diabetes
receiving oral antidiabetic/cardio-protective medication and of those reaching
treatment goals for glycemic control (HbA1c<7%, 60% to 71%, p = 0.09), blood
pressure (<140/80 mmHg, 25% to 69%, p<0.001) and LDL cholesterol (<2.6 mmol/l,
13% to 27%, p<0.001) increased significantly. However, improvements were
generally smaller from 2007 to 2014 than from 2000 to 2007. Modeled 10-year CHD
risk decreased from 30% in 2000 to 24% in 2007 to 19% in 2014 (p<0.01). From 2007
to 2014, the prevalence of microvascular complications decreased and quality of
life increased, but no improvements were observed for the majority of indicators
of self-management.
CONCLUSION: Despite improvements, medication and risk factor control has remained
suboptimal. The flattening of improvements and deteriorations in quality of
(self-) care since 2007 indicate that more effort is needed to improve quality of
care and patient self-management. Due to selection or lead time bias an
overestimation of quality of care improvements cannot be ruled out.
DOI: 10.1371/journal.pone.0164704
PMCID: PMC5066975
PMID: 27749939 [Indexed for MEDLINE]
Nagae M(1), Nakane H(2), Honda S(3), Ozawa H(4), Hanada H(1).
Author information:
(1)Department of Nursing, Nagasaki University Graduate School of Biomedical
Sciences, Nagasaki, Japan.
(2)Department of Psychiatric Rehabilitation Sciences, Nagasaki University
Graduate School of Biomedical Sciences, Nagasaki, Japan.
(3)Department of Community-Based Rehabilitation Sciences, Nagasaki University
Graduate School of Biomedical Sciences, Nagasaki, Japan.
(4)Department of Neuropsychiatry, Nagasaki University Graduate School of
Biomedical Sciences, Nagasaki, Japan.
DOI: 10.1111/jcap.12113
PMCID: PMC6088225
PMID: 25989262 [Indexed for MEDLINE]
1007. J Rural Med. 2015;10(2):79-83. doi: 10.2185/jrm.2900. Epub 2015 Dec 23.
Hirakawa Y(1), Hilawe EH(1), Chiang C(1), Kawazoe N(1), Aoyama A(1).
Author information:
(1)Department of Public Health and Health Systems, Nagoya University Graduate
School of Medicine, Japan.
DOI: 10.2185/jrm.2900
PMCID: PMC4689736
PMID: 26705432
DOI: 10.1176/appi.ps.201300092
PMCID: PMC4183704
PMID: 24932755 [Indexed for MEDLINE]
Hypoglycemia prediction using machine learning models for patients with type 2
diabetes.
Author information:
(1)WellDoc, Inc, Baltimore, MD, USA.
(2)WellDoc, Inc, Baltimore, MD, USA mshomali@welldocinc.com.
DOI: 10.1177/1932296814554260
PMCID: PMC4495530
PMID: 25316712 [Indexed for MEDLINE]
Author information:
(1)Department of Medicine, Mylan, Madrid.
(2)Department of Endocrinology and Nutrition, Doctor Peset University Hospital,
Valencia.
(3)Department of Medicine, University of Valencia, Valencia.
(4)Department for Primary Health Care, Centro de Salud Sillería, Toledo.
(5)Outcomes'10, Castellon.
(6)Department of Biochemistry and Molecular Biology, Faculty of Pharmacy,
University of Granada, Granada, Spain.
OBJECTIVE: A good relationship between diabetes patients and their health care
team is crucial to ensure patients' medication adherence and self-management. To
this end, we aimed to identify and compare the views of type 2 diabetes mellitus
(T2DM) patients, physicians and pharmacists concerning the factors and strategies
that may be associated with, or could improve, medication adherence and
persistence.
METHODS: An observational, cross-sectional study was conducted using an
electronic self-administered questionnaire comprising 11 questions (5-point
Likert scale) concerning factors and strategies related to medication adherence.
The survey was designed for T2DM patients and Spanish National Health System
professionals.
RESULTS: A total of 963 T2DM patients, 998 physicians and 419 pharmacists
participated in the study. Overall, a lower proportion of pharmacists considered
the proposed factors associated with medication adherence important as compared
to patients and physicians. It should be noted that a higher percentage of
physicians in comparison to pharmacists perceived that "complexity of medication"
(97% vs 76.6%, respectively) and "adverse events" (97.5% vs 72.2%, respectively)
were important medication-related factors affecting adherence. In addition, both
patients (80.8%) and physicians (80.8%) agreed on the importance of "cost and
co-payment" for adherence, whereas only 48.6% of pharmacists considered this
factor important. It is also noteworthy that nearly half of patients (43%) agreed
that "to adjust medication to activities of daily living" was the best strategy
to reduce therapeutic complexity, whereas physicians believed that "reducing the
frequency of administration" (47.9%) followed by "reducing the number of tablets"
(28.5%) was the most effective strategy to improve patients' adherence.
CONCLUSION: Our results highlight the need for pharmacists to build a stronger
relationship with physicians in order to improve patients monitoring and
adherence rates. Additionally, these findings may help to incorporate greater
patient-centeredness when developing management strategies, focusing on adjusting
medication regimens to patients' daily lives.
DOI: 10.2147/PPA.S122556
PMCID: PMC5388272
PMID: 28435229
1011. Res Nurs Health. 2015 Aug;38(4):289-300. doi: 10.1002/nur.21663. Epub 2015
May
11.
Predictors of medication nonadherence differ among black and white patients with
heart failure.
Author information:
(1)Assistant Professor College of Nursing, New York University, 433 First Avenue,
#742, New York, NY, 10010.
(2)Professor School of Nursing, University of North Carolina, Chapel Hill, NC.
(3)Professor and Edith Clemmer Steinbright Chair of Gerontology School of
Nursing, University of Pennsylvania, Philadelphia, PA.
Heart failure (HF) is a global public health problem, and outcomes remain poor,
especially among ethnic minority populations. Medication adherence can improve
heart failure outcomes but is notoriously low. The purpose of this secondary
analysis of data from a prospective cohort comparison study of adults with heart
failure was to explore differences in predictors of medication nonadherence by
racial group (Black vs. White) in 212 adults with heart failure. Adaptive
modeling analytic methods were used to model HF patient medication nonadherence
separately for Black (31.7%) and White (68.3%) participants in order to
investigate differences between these two racial groups. Of the 63 Black
participants, 33.3% had low medication adherence, compared to 27.5% of the 149
White participants. Among Blacks, 16 risk factors were related to adherence in
bivariate analyses; four of these (more comorbidities, lower serum sodium, higher
systolic blood pressure, and use of fewer activities compensating for
forgetfulness) jointly predicted nonadherence. In the multiple risk factor model,
the number of risk factors in Black patients ranged from 0 to 4, and 76.2% had at
least one risk factor. The estimated odds ratio for medication nonadherence was
increased 9.34 times with each additional risk factor. Among White participants,
five risk factors were related to adherence in bivariate analyses; one of these
(older age) explained the individual effects of the other four. Because Blacks
with HF have different and more risk factors than Whites for low medication
adherence, interventions are needed that address unique risk factors among Black
patients with HF.
DOI: 10.1002/nur.21663
PMCID: PMC4503510
PMID: 25962474 [Indexed for MEDLINE]
Author information:
(1)Department of Internal Nursing, School of Health Sciences, Medical University
of Silesia, Katowice, Poland, mlynarska83@gmail.com.
(2)Department of Electrocardiology, Upper Silesian Heart Centre, Katowice,
Poland, mlynarska83@gmail.com.
(3)Department of Electrocardiology and Heart Failure, School of Health Sciences,
Medical University of Silesia, Katowice, Poland.
DOI: 10.2147/CIA.S178393
PMCID: PMC6183697
PMID: 30349210 [Indexed for MEDLINE]
1013. Pharmacy (Basel). 2017 Sep 8;5(3). pii: E52. doi: 10.3390/pharmacy5030052.
Validating the Modified Drug Adherence Work-Up (M-DRAW) Tool to Identify and
Address Barriers to Medication Adherence.
Author information:
(1)College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766,
USA. slee22@westernu.edu.
(2)School of Pharmacy, University of Southern California, Los Angeles, CA 90089,
USA. jaehee616@gmail.com.
(3)College of Pharmacy, Ohio State University, Columbus, OH 43210, USA.
worley.18@osu.edu.
(4)College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766,
USA. alaw@westernu.edu.
DOI: 10.3390/pharmacy5030052
PMCID: PMC5622364
PMID: 28970464
Kolmodin MacDonell K(1), Naar S(2), Gibson-Scipio W(3), Lam P(4), Secord E(2).
Author information:
(1)Department of Family Medicine and Public Health Sciences, Wayne State
University School of Medicine, Detroit, Michigan. Electronic address:
kkolmodin@med.wayne.edu.
(2)Department of Family Medicine and Public Health Sciences, Wayne State
University School of Medicine, Detroit, Michigan.
(3)College of Nursing, Wayne State University, Detroit, Michigan.
(4)University of Windsor, Faculty of Arts, Humanities, and Social Sciences,
Windsor, Ontario, Canada.
DOI: 10.1016/j.jadohealth.2016.05.016
PMCID: PMC5035614
PMID: 27475032 [Indexed for MEDLINE]
Alsulami SL(1), Sardidi HO, Almuzaini RS, Alsaif MA, Almuzaini HS, Moukaddem AK,
Kharal MS.
Author information:
(1)College of Medicine, King Saud bin Abdulaziz University for Health Sciences,
Riyadh, Kingdom of Saudi Arabia. E-mail:. alsulamisalma994@gmail.com.
OBJECTIVES: To assess knowledge, attitudes and practices towards the reporting of
medication errors among health practitioners at King Abdulaziz Medical city in
Riyadh, Kingdom of Saudi Arabia. Methods: A cross-sectional study using a
self-administered questionnaire was conducted in a convenient sample of 62
physicians and 303 nurses, between June and September 2017 at King Abdulaziz
Medical City, Riyadh, Kingdom of Saudi Arabia. Results: The sample consisted of
365 subjects, with a response rate of 73%. Approximately 97% had
sufficient knowledge and a favorable attitude (90%) towards medication error
reporting. With regard to reporting practices, some participants (21.6%)
preferred to educate those who made a medication error, rather than reporting it.
Approximately 44.8% had not reported medication errors during their work
experience. Conclusion: Study participants demonstrated a sufficient knowledge
base with regard to medication error reporting. Despite sufficient knowledge and
favorable attitudes towards medication error reporting, there is still an
under-reporting of medication errors when it comes to practice. We recommend the
establishment of frequent medication safety courses as a prerequisite for all
health care providers. We also advocate the application of error detecting alarms
such as digital programs to minimize medication errors.
DOI: 10.15537/smj.2019.3.23960
PMCID: PMC6468206
PMID: 30834419 [Indexed for MEDLINE]
Author information:
(1)National Institute of Psychology, Center of Excellence, Quaid-i-Azam
University, Islamabad, Pakistan.
(2)Professor of Psychology, Director of Clinical Training, University of Miami,
Coral Gables, USA.
Onturk ZK(1), Ugur E(1), Kocatepe V(1), Ates E(1), Ocaktan N(1), Unver V(1),
Karabacak U(1).
Author information:
(1)Acibadem Mehmet Ali Aydinlar University, Faculty of Health Sciences, Nursing
Department, Turkey.
PMID: 30804583
1018. Addict Biol. 2017 Nov;22(6):1515-1527. doi: 10.1111/adb.12425. Epub 2016 Jul
14.
Author information:
(1)Campbell Family Mental Health Research Institute, Centre for Addiction and
Mental Health, Canada.
(2)Department of Psychiatry, University of Toronto, Canada.
(3)Department of Psychology, University of Toronto, Canada.
(4)Institute for Mental Health Policy Research, Centre for Addiction and Mental
Health, Canada.
(5)Institute for Medical Sciences, University of Toronto, Canada.
(6)Dalla Lana School of Public Health, University of Toronto, Canada.
(7)Technische Universität, Germany.
DOI: 10.1111/adb.12425
PMCID: PMC6139429
PMID: 27411969 [Indexed for MEDLINE]
Bernhard G(1), Mahler C(1), Seidling HM(2)(3), Stützle M(2)(3), Ose D(1)(4),
Baudendistel I(1), Wensing M(1), Szecsenyi J(1).
Author information:
(1)Department of General Practice and Health Services Research, Heidelberg
University Hospital, Heidelberg, Germany.
(2)Cooperation Unit Clinical Pharmacy, Heidelberg University Hospital,
Heidelberg, Germany.
(3)Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg
University Hospital, Heidelberg, Germany.
(4)Division of Cancer Population Sciences, Department of Population Health
Sciences, University of Utah, Salt Lake City, UT, United States.
©Gerda Bernhard, Cornelia Mahler, Hanna Marita Seidling, Marion Stützle, Dominik
Ose, Ines Baudendistel, Michel Wensing, Joachim Szecsenyi. Originally published
in the Journal of Medical Internet Research (http://www.jmir.org), 27.03.2018.
DOI: 10.2196/jmir.8666
PMCID: PMC5893891
PMID: 29588269 [Indexed for MEDLINE]
DOI: 10.1310/hpj5204-308
PMCID: PMC5424837
PMID: 28515512
Author information:
(1)Department of Health Education and Health Promotion, Bushehr University of
Medical Sciences, Bushehr, Iran.
(2)Department of Biostatistics, Bushehr University of Medical Sciences, Bushehr,
Iran.
The aim of this study was to determine the factors influencing adherence to
self-care behaviors among low health literacy hypertensive patients based on
health belief model. A cross-sectional study was conducted among 152 hypertensive
patients with low health literacy. Patients with limited health literacy were
identified by S-TOFHLA. The data were collected using H-scale for assessing
self-care behaviors and, HK-LS for assessing knowledge of hypertension. A
researcher-made questionnaire was applied for collecting data of health belief
model constructs. Data were analyzed by SPSS version 22 with using multiple
logistic regression analyses. Perceived self-efficacy was associated with all
self-care behaviors except medication regimens. There was a significant
association between perceived susceptibility and adherence to both low-salt diet
(OR = 3.47) and nonsmoking behavior (OR = 1.10). Individuals who had more
perceived severity (OR = 1.82) had significantly greater adherence to their
medication regimens. Perceived benefits and barriers were not significantly
associated with either type of hypertension self-care behaviors. It seems that
designing and implementation of educational programs to increase self-efficacy of
patients and promote their beliefs about perceived susceptibility and severity of
complications may improve self-care behaviors among low health literacy
hypertensive patients.
DOI: 10.1155/2018/9752736
PMCID: PMC5893004
PMID: 29780639
Erratum for
PLoS One. 2016 Jul 01;11(7):e0158499.
Author information:
(1)Pharmacy Department, Wollega University, Nekemte, Ethiopia.
bushagemechu1@gmail.com.
(2)Department of Epidemiology, Jimma University, Jimma, Ethiopia.
(3)Pharmacy Department, Wollega University, Nekemte, Ethiopia.
(4)Pharmacy Department, Jimma University, Jimma, Ethiopia.
DOI: 10.1186/s13104-019-4125-3
PMCID: PMC6376695
PMID: 30764868 [Indexed for MEDLINE]
Umeukeje EM(1)(2), Merighi JR(3), Browne T(4), Wild M(1)(2), Alsmaan H(5),
Umanath K(5), Lewis JB(1)(2), Wallston KA(6), Cavanaugh KL(7)(8).
Author information:
(1)Division of Nephrology and Hypertension, Vanderbilt University Medical Center,
1161 21st Avenue MCN S-3223, Nashville, TN, 37232, USA.
(2)Vanderbilt Center for Kidney Disease, Nashville, TN, USA.
(3)School of Social Work, University of Minnesota, Saint Paul, MN, USA.
(4)College of Social Work, University of South Carolina, Columbia, SC, USA.
(5)Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, MI,
USA.
(6)Vanderbilt University School of Nursing, Nashville, TN, USA.
(7)Division of Nephrology and Hypertension, Vanderbilt University Medical Center,
1161 21st Avenue MCN S-3223, Nashville, TN, 37232, USA.
kerri.cavanaugh@vanderbilt.edu.
(8)Vanderbilt Center for Kidney Disease, Nashville, TN, USA.
kerri.cavanaugh@vanderbilt.edu.
Erratum in
J Behav Med. 2019 Jan 8;:.
This study was designed to assess dialysis subjects' perceived autonomy support
association with phosphate binder medication adherence, race and gender. A
multi-site cross-sectional study was conducted among 377 dialysis subjects. The
Health Care Climate (HCC) Questionnaire assessed subjects' perception of their
providers' autonomy support for phosphate binder use, and adherence was assessed
by the self-reported Morisky Medication Adherence Scale. Serum phosphorus was
obtained from the medical record. Regression models were used to examine
independent factors of medication adherence, serum phosphorus, and differences by
race and gender. Non-white HCC scores were consistently lower compared with white
subjects' scores. No differences were observed by gender. Reported phosphate
binder adherence was associated with HCC score, and also with phosphorus control.
No significant association was found between HCC score and serum phosphorus.
Autonomy support, especially in non-white end stage renal disease subjects, may
be an appropriate target for culturally informed strategies to optimize mineral
bone health.
DOI: 10.1007/s10865-016-9745-7
PMCID: PMC5512866
PMID: 27167227 [Indexed for MEDLINE]
1025. Diabet Med. 2014 Oct;31(10):1237-44. doi: 10.1111/dme.12453. Epub 2014 Apr
18.
Author information:
(1)Department of Sociology, Loyola University Maryland, Baltimore, MD, USA.
AIMS: To develop and validate a short form of the 54-item Diabetes Medication
System Rating Questionnaire that maintains the domains and performance
characteristics of the long-form questionnaire.
METHODS: Data from the Diabetes Medication System Rating Questionnaire validation
study were analysed to select items representing the nine scales (convenience,
negative events, interference, self-monitoring of blood glucose burden, efficacy,
social burden, psychological well-being, treatment satisfaction and treatment
preference). The resulting 20-item Diabetes Medication System Rating
Questionnaire Short-Form was administered online, with validated criterion
measures of treatment satisfaction and medication adherence, with a retest within
2 weeks. Participants were US adults (N = 413) with Type 2 diabetes using oral
agents alone; insulin by syringe and/or pen with or without oral agents; or
glucagon-like peptide-1 agents. Most participants (82%) completed the retest.
RESULTS: The median inter-item agreement of scales was 0.76 and the total
composite (mean of all items except treatment preference) was 0.88. The median
test-retest reliability of scales was 0.86, and of the total composite was 0.95.
All statistically significant correlations between Diabetes Medication System
Rating Questionnaire Short-Form scales and criterion measures of treatment
satisfaction and adherence were in the expected direction. The median correlation
of the Diabetes Medication System Rating Questionnaire Short-Form with
corresponding criterion measures of treatment satisfaction was 0.59; the mean
correlation of the same Diabetes Medication System Rating Questionnaire
Short-Form measures with adherence was 0.42. The Diabetes Medication System
Rating Questionnaire Short-Form scales were more powerful predictors of adherence
than were the criterion measures of treatment satisfaction. The Diabetes
Medication System Rating Questionnaire Short-Form scales differentiated between
those taking different medications and between those using different insulin
delivery devices.
CONCLUSIONS: This study suggests that the Diabetes Medication System Rating
Questionnaire Short-Form provides a comprehensive set of measures with acceptable
reliability and validity and a reduced burden of administration.
© 2014 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on
behalf of Diabetes UK.
DOI: 10.1111/dme.12453
PMCID: PMC4232890
PMID: 24673614 [Indexed for MEDLINE]
Author information:
(1)Department of Psychology, Virginia Commonwealth University, P.O. Box 842018,
Richmond, VA 23284-2018, United States. Electronic address: apborschuk@vcu.edu.
(2)Department of Psychology, Virginia Commonwealth University, P.O. Box 842018,
Richmond, VA 23284-2018, United States. Electronic address: reverhart@vcu.edu.
(3)Division of Pulmonary and Critical Care Medicine, Johns Hopkins Adherence
Research Center, Johns Hopkins School of Medicine, United States. Electronic
address: meakin1@jhmi.edu.
(4)Division of Pulmonary and Critical Care Medicine, Johns Hopkins Adherence
Research Center, Johns Hopkins School of Medicine, United States. Electronic
address: drandgio@gmail.com.
(5)Department of Health Policy & Health Services Research, Boston University, 560
Harrison Avenue, Boston, MA 02118, United States. Electronic address:
belindab@bu.edu.
(6)Division of Pulmonary and Critical Care Medicine, Johns Hopkins Adherence
Research Center, Johns Hopkins School of Medicine, United States. Electronic
address: riekert@jhmi.edu.
BACKGROUND: This study aimed to quantify cystic fibrosis (CF) disclosure and
examine associations between disclosure and psychosocial and health outcomes.
METHODS: Participants completed measures assessing disease disclosure and
psychosocial outcomes. Data from chart reviews and pharmacy records were
obtained.
RESULTS: Participants (N=128; ages 16-63) were more likely to disclose to
romantic partners (97%) and close friends (94%) than to casual friends (79%),
bosses (71%), or co-workers (53%). Participants reported more comfort discussing
CF with and doing treatments in front of romantic partners and close friends than
other groups. Disclosure was associated with higher social support, social
functioning, and medication adherence self-efficacy. Lower lung-function was
associated with disclosure to bosses and co-workers.
CONCLUSIONS: Clinicians should consider discussing disclosure with patients, as
limited disclosure may have a negative impact on psychosocial outcomes.
Copyright © 2016 European Cystic Fibrosis Society. Published by Elsevier B.V. All
rights reserved.
DOI: 10.1016/j.jcf.2016.02.011
PMCID: PMC6512333
PMID: 26996270 [Indexed for MEDLINE]
Author information:
(1)Department of Pharmacology, Sri Siddhartha Medical College, Tumakuru,
Karnataka, India.
(2)Division of Clinical Pharmacology, St. John's Medical College and Hospital,
Bengaluru, Karnataka, India.
(3)Department of Psychiatry, St. John's Medical College and Hospital, Bengaluru,
Karnataka, India.
DOI: 10.4103/0976-500X.184770
PMCID: PMC4936082
PMID: 27440951
1028. Diabetes Technol Ther. 2015 Feb;17(2):80-7. doi: 10.1089/dia.2014.0166. Epub
2014
Oct 31.
Author information:
(1)1 Health Equity and Rural Outreach Innovation Center, Charleston Veterans
Affairs Health Services Research and Development Service Center of Innovation,
Ralph H. Johnson Veterans Administration Medical Center , Charleston, South
Carolina.
BACKGROUND: The aim of this study was to investigate if self-care is the pathway
through which social determinants of health impact diabetes outcomes by analyzing
the direct and indirect effects of socioeconomic and psychosocial factors on
self-care and glycemic control.
SUBJECTS AND METHODS: Six hundred fifteen adults were recruited from two primary
care clinics in the southeastern United States. A series of confirmatory factor
analyses identified the latent factors underlying social status, psychosocial
determinants (psychological distress, self-efficacy, and social support), and
self-care (diet, exercise, foot care, glucose testing, and medication adherence).
Structured equation modeling investigated the relationship among social
determinants, self-care and glycemic control.
RESULTS: Latent variables were created for diabetes self-care, psychological
distress, self-efficacy, social support, and social status. The final model
[χ(2)(275)=450.07, P<0.001, R(2)=99, root mean square error of
approximation=0.03, comparative fit index=0.98] showed lower psychological
distress (r=-0.13, P=0.012), higher social support (r=0.14, P=0.01), and higher
self-efficacy (r=0.47, P<0.001) were significantly related to diabetes self-care.
Lower psychological distress (r=0.10, P=0.03), lower social support (r=0.10,
P=0.02), and higher self-efficacy (r=-0.37, P<0.001) were significantly related
to lower glycemic control. When social determinants of health variables were
included in the model, self-care was no longer significantly associated with
glycemic control (r=0.01, P=0.83).
CONCLUSIONS: This study suggests a direct relationship between psychosocial
determinants of health and glycemic control. Although associated with self-care,
the relationship between social determinants of health and glycemic control is
not mediated by self-care. Development of interventions should take psychosocial
factors into account as independent influences on diabetes outcomes, rather than
as indirect influences via self-care behavior.
DOI: 10.1089/dia.2014.0166
PMCID: PMC4322090
PMID: 25361382 [Indexed for MEDLINE]
DOI: 10.1016/j.japh.2016.01.005
PMID: 27053077 [Indexed for MEDLINE]
Author information:
(1)University of British Columbia Vancouver, and Arthritis Research Centre of
Canada, Richmond, British Columbia, Canada.
DOI: 10.1002/acr.22336
PMID: 24692321 [Indexed for MEDLINE]
Author information:
(1)Ulster University, Jordanstown Campus, Shore Road, Newtownabbey, County
Antrim, BT37 0QB, United Kingdom. Electronic address: l.lawther@qub.ac.uk.
(2)Ulster University, Jordanstown Campus, Shore Road, Newtownabbey, County
Antrim, BT37 0QB, United Kingdom.
(3)Belfast Health and Social Care Trust, Royal Victoria Hospital, 274 Grosvenor
Road, Belfast, BT12 6BA, United Kingdom.
DOI: 10.1016/j.seizure.2018.05.003
PMID: 29778017 [Indexed for MEDLINE]
1032. NPJ Prim Care Respir Med. 2017 Jul 20;27(1):46. doi: 10.1038/s41533-017-0046-
6.
Author information:
(1)Public Health, Solihull Metropolitan Borough Council, Solihull, B91 3QB, UK.
(2)Institute of Applied Health Research, University of Birmingham, Birmingham,
B15 2TT, UK. a.p.dickens@bham.ac.uk.
(3)Institute of Applied Health Research, University of Birmingham, Birmingham,
B15 2TT, UK.
DOI: 10.1038/s41533-017-0046-6
PMCID: PMC5519687
PMID: 28729620 [Indexed for MEDLINE]
Bosmans JE(1), van der Laan DM(2), Yang Y(2), Elders PJM(3), Boons CCLM(2),
Nijpels G(3), Hugtenburg JG(2).
Author information:
(1)Department of Health Sciences, Faculty of Science, Amsterdam Public Health
Research Institute, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
(2)Department of Clinical Pharmacology and Pharmacy, Amsterdam Public Health
Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam,
Netherlands.
(3)Department of General Practice & Elderly Care Medicine, Amsterdam Public
Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam,
Amsterdam, Netherlands.
Psychotropic Medication and Substance Use during Pregnancy by Women with Severe
Mental Illness.
Brameld KJ(1), Jablensky A(2), Griffith J(3), Dean J(3), Morgan VA(2).
Author information:
(1)Neuropsychiatric Epidemiology Research Unit, School of Psychiatry and Clinical
Neurosciences, The University of Western Australia, Crawley, WA, Australia;
Centre for Population Health Research, Faculty of Health Sciences, Curtin
University, Perth, WA, Australia.
(2)Neuropsychiatric Epidemiology Research Unit, School of Psychiatry and Clinical
Neurosciences, The University of Western Australia, Crawley, WA, Australia;
Centre for Clinical Research in Neuropsychiatry, School of Psychiatry and
Clinical Neurosciences, The University of Western Australia, Crawley, WA,
Australia.
(3)Neuropsychiatric Epidemiology Research Unit, School of Psychiatry and Clinical
Neurosciences, The University of Western Australia , Crawley, WA , Australia.
Erratum for
BMJ Open. 2017 Jun 23;7(6):e014435.
DOI: 10.1136/bmjopen-2016-014435corr1
PMCID: PMC5624126
PMID: 28864490
DOI: 10.1016/j.japh.2018.03.005
PMCID: PMC6035879
PMID: 29691197
Author information:
(1)Department of Psychology, Simon Fraser University, 8888 University Drive,
Burnaby, BC V5A 1S6, Canada.
(2)Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
DOI: 10.1093/ckj/sfw076
PMCID: PMC5162408
PMID: 27994867
Author information:
(1)School of Pharmacy, Virginia Commonwealth University, 410 North 12th Street,
PO Box 980533, Richmond, VA 23298-0533, United States. Electronic address:
abcoe@vcu.edu.
(2)School of Pharmacy, Virginia Commonwealth University, 410 North 12th Street,
PO Box 980533, Richmond, VA 23298-0533, United States.
(3)Daily Planet, Richmond, Virginia, United States.
DOI: 10.1016/j.sapharm.2012.11.004
PMCID: PMC3733792
PMID: 23218849 [Indexed for MEDLINE]
Hayward KL(1), Valery PC(2), Martin JH(3), Karmakar A(4), Patel PJ(5), Horsfall
LU(5), Tallis CJ(6), Stuart KA(6), Wright PL(6), Smith DD(7), Irvine KM(5),
Powell EE(5), Cottrell WN(8).
Author information:
(1)Pharmacy Department, Princess Alexandra Hospital, The Centre for Liver Disease
Research, Translational Research Institute, The University of Queensland,
Woolloongabba, Queensland 4102, Australia.
(2)Cancer and Chronic Disease Research Group, QIMR Berghofer Medical Research
Institute, Herston, Queensland 4006, Australia.
(3)School of Medicine and Public Health, The University of Newcastle, Callaghan,
New South Wales 2308, Australia.
(4)The Centre for Liver Disease Research, Translational Research Institute, The
University of Queensland, Woolloongabba, Queensland 4102, Australia.
(5)Department of Gastroenterology and Hepatology, Princess Alexandra Hospital,
The Centre for Liver Disease Research, Translational Research Institute, The
University of Queensland, Woolloongabba, Queensland 4102, Australia.
(6)Department of Gastroenterology and Hepatology, Princess Alexandra Hospital,
Woolloongabba, Queensland 4102, Australia.
(7)Statistics Unit, QIMR Berghofer Medical Research Institute, Herston,
Queensland 4006, Australia.
(8)School of Pharmacy, The University of Queensland, Woolloongabba, Queensland
4102, Australia. n.cottrell@uq.edu.au.
DOI: 10.3748/wjg.v23.i40.7321
PMCID: PMC5677197
PMID: 29142479 [Indexed for MEDLINE]
Czoty PW(1), Blough BE(2), Fennell TR(2), Snyder RW(2), Nader MA(3).
Author information:
(1)Department of Physiology and Pharmacology, Wake Forest School of Medicine,
Winston-Salem, NC 27157, United States. Electronic address:
pczoty@wakehealth.edu.
(2)Discovery Sciences, Research Triangle Institute, Research Triangle Park, NC
27709, United States.
(3)Department of Physiology and Pharmacology, Wake Forest School of Medicine,
Winston-Salem, NC 27157, United States; Department of Radiology, Wake Forest
School of Medicine, Winston-Salem, NC 27157, United States.
Chronic treatment with the monoamine releaser d-amphetamine has been consistently
shown to decrease cocaine self-administration in laboratory studies and clinical
trials. However, the abuse potential of d-amphetamine is an obstacle to
widespread clinical use. Approaches are needed that exploit the efficacy of the
agonist approach but avoid the abuse potential associated with dopamine
releasers. The present study assessed the effectiveness of chronic oral
administration of phendimetrazine (PDM), a pro-drug for the monoamine releaser
phenmetrazine (PM), to decrease cocaine self-administration in four rhesus
monkeys. Each day, monkeys pressed a lever to receive food pellets under a
50-response fixed-ratio (FR) schedule of reinforcement and self-administered
cocaine (0.003-0.56 mg/kg per injection, i.v.) under a progressive-ratio (PR)
schedule in the evening. After completing a cocaine self-administration
dose-response curve, sessions were suspended and PDM was administered (1.0-9.0
mg/kg, p.o., b.i.d.). Cocaine self-administration was assessed using the PR
schedule once every 7 days while food-maintained responding was studied daily.
When a persistent decrease in self-administration was observed, the cocaine
dose-effect curve was re-determined. Daily PDM treatment decreased cocaine
self-administration by 30-90% across monkeys for at least 4 weeks. In two
monkeys, effects were completely selective for cocaine. Tolerance developed to
initial decreases in food-maintained responding in the third monkey and in the
fourth subject, fluctuations were observed that were lower in magnitude than
effects on cocaine self-administration. Cocaine dose-effect curves were shifted
down and/or rightward in three monkeys. These data provide further support for
the use of agonist medications for cocaine abuse, and indicate that the promising
effects of d-amphetamine extend to a more clinically viable pharmacotherapy.
DOI: 10.1016/j.neuroscience.2016.03.002
PMCID: PMC4838503
PMID: 26964683 [Indexed for MEDLINE]
Morgan C(1), McBeth J(2), Cordingley L(3), Watson K(1), Hyrich KL(4), Symmons
DP(4), Bruce IN(5).
Author information:
(1)Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal
Research, Institute of Inflammation and Repair, University of Manchester,
Manchester Academic Health Science Centre, Manchester.
(2)Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal
Research, Institute of Inflammation and Repair, University of Manchester,
Manchester Academic Health Science Centre, Manchester, Research Institute for
Primary Care & Health Sciences, Keele University, Keele.
(3)Institute of Inflammation & Repair, University of Manchester, Manchester
Academic Health Science Centre and.
(4)Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal
Research, Institute of Inflammation and Repair, University of Manchester,
Manchester Academic Health Science Centre, Manchester, NIHR Manchester
Musculoskeletal Biomedical Research Unit, Central Manchester University Hospital
NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
(5)Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal
Research, Institute of Inflammation and Repair, University of Manchester,
Manchester Academic Health Science Centre, Manchester, NIHR Manchester
Musculoskeletal Biomedical Research Unit, Central Manchester University Hospital
NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
Ian.bruce@manchester.ac.uk.
© The Author 2015. Published by Oxford University Press on behalf of the British
Society for Rheumatology.
DOI: 10.1093/rheumatology/kev105
PMCID: PMC4571488
PMID: 25972390 [Indexed for MEDLINE]
1042. Adv Biomed Res. 2015 Sep 28;4:204. doi: 10.4103/2277-9175.166140. eCollection
2015.
Effect of self-care education on lifestyle modification, medication adherence and
blood pressure in hypertensive adults: Randomized controlled clinical trial.
Author information:
(1)Isfahan Cardiovascular Research Center, Cardiovascular Research Institute,
Isfahan University of Medical Sciences, Isfahan, Iran.
(2)Cardiac Rehabilitation Research Center, Cardiovascular Research Institute,
Isfahan University of Medical Sciences, Isfahan, Iran.
(3)Hypertension Research Center, Cardiovascular Research Institute, Isfahan
University of Medical Sciences, Isfahan, Iran.
(4)Heart Failure Research Centre, Cardiovascular Research Institute, Isfahan
University of Medical Sciences, Isfahan, Iran.
DOI: 10.4103/2277-9175.166140
PMCID: PMC4620611
PMID: 26601092
Author information:
(1)Department of Psychiatry and Behavioral Sciences, Duke University School of
Medicine, Durham, NC.
(2)Department of Medicine, Division of General Medicine, Duke University School
of Medicine, Durham, NC.
(3)Center for Health Services Research in Primary Care, Durham VAMC, Durham, NC.
Introduction: Efficacious pharmacological interventions for smoking cessation are
available, but poor adherence to these treatments may limit these interventions
overall impact. To improve adherence to smoking cessation interventions, it is
first necessary to identify and understand smoker-level characteristics that
drive nonadherence (ie, nonconformance with a provider's recommendation of
timing, dosage, or frequency of medication-taking during the prescribed length of
time).
Methods: We present a literature review of studies examining correlates of, or
self-reported reasons for, nonadherence to smoking cessation pharmacotherapies.
Studies were identified through PubMed-using MeSH terms, Embase-using Emtree
terms, and ISI Web of Science.
Results and Conclusions: This literature review included 50 studies that examined
nonpreventable (eg, sociodemographics) and preventable (eg, forgetfulness)
factors associated with adherence to smoking cessation medication and suggestions
for overcoming some of the identified barriers. Systematic study of this topic
would be facilitated by consistent reporting of adherence and correlates thereof
in the literature, development of consistent definitions of medication adherence
across studies, utilization of more objective measures of adherence (eg, blood
plasma levels vs. self-report) in addition to reliance on self-reported
adherence.
Implications: This article provides the most comprehensive review to date on
correlates of adherence to pharmacological smoking cessation interventions.
Challenges and specific gaps in the literature that should be a priority for
future research are discussed. Future priorities include additional research,
particularly among vulnerable populations of smokers, developing standardized
definitions of adherence and methods for measuring adherence, regular assessment
of cessation pharmacotherapy adherence in the context of research and clinical
practice, and development of novel treatments aimed at preventable barriers to
medication adherence.
DOI: 10.1093/ntr/ntx210
PMCID: PMC6121917
PMID: 29059394
Author information:
(1)2nd Medical Division, Rheumatology, Kaiser Franz Josef Hospital, SMZ-Süd,
Kundratstrasse 3, 1100 Vienna, Karl Landsteiner Society of Autoimmunology and
Rheumatism, Austria.
(2)Institute of Social Medicine, Centre for Public Health, Medical University of
Vienna, Kinderspitalgasse 15/1, 1090 Vienna, Austria.
Objectives: The aim of this study was to determine if strategies for coping with
illnesses, demographic factors, and clinical factors were associated with
medication adherence among patients with rheumatoid arthritis (RA).
Methods: This cross-sectional study was conducted at a Viennese rheumatology
outpatient clinic on RA patients. Medication adherence was assessed using the
Medication Adherence Report Scale. Strategies for coping with illness were
assessed using the Freiburg Questionnaire for Coping with Illness.
Results: Half (N=63, 52.5%) of the 120 patients included in the study were
considered completely medication adherent. Female sex (odds ratio [OR]: 4.57, 95%
confidence interval [CI]: 1.14 - 18.42), older age (54-65 yr vs. <45 yr OR: 9.2,
CI:2.0-40.70; >65 yr vs. <45 yr OR 6.93, CI:1,17 - 40.87), middle average income
(middle average income vs. lowest income class OR= 0.06, CI= 0.01-0.43), and
shorter disease duration (5-10 yr vs. >10 yr OR= 3.53, CI= 1.04-11.95; 1-4 yr vs.
>10 yr OR=3.71, CI= 1.02-13.52) were associated with higher medication adherence.
Levels of active coping (15.57 vs. 13.47, p=0.01) or diversion and
self-encouragement (16.10 vs. 14.37, p=0.04) were significantly higher among
adherent as opposed to less adherent participants. However, in multivariate
regression models, coping strategies were not significantly associated with
adherence.
Conclusions: Age, sex, monthly net income, and disease duration were found to be
associated with an increased risk for medication nonadherence among patients with
RA. Coping strategies such as active coping, diversion, and self-encouragement
were associated with adherence in univariate models, but not when adjusted for
demographic and clinical factors.
DOI: 10.1155/2019/4709645
PMCID: PMC6425297
PMID: 30949207
Krawczyk N(1)(2), Negron T(1), Nieto M(1), Agus D(1)(2), Fingerhood MI(1)(3).
Author information:
(1)a Department of Mental Health , Johns Hopkins Bloomberg School of Public
Health , Baltimore , Maryland , USA.
(2)b Behavioral Health Leadership Institute , Baltimore , Maryland , USA.
(3)c Johns Hopkins University School of Medicine , Baltimore , Maryland , USA.
1046. BMC Health Serv Res. 2015 Apr 19;15:168. doi: 10.1186/s12913-015-0820-5.
Author information:
(1)Department of Health Policy, Planning and Management, School of Public Health,
Makerere University College of Health Sciences, Kampala, Uganda.
jbagonza@musph.ac.ug.
(2)Department of Health Policy, Planning and Management, School of Public Health,
Makerere University College of Health Sciences, Kampala, Uganda.
ellie@musph.ac.ug.
(3)Department of Disease Control and Environmental Health, School of Public
Health, Makerere University College of Health Sciences, Kampala, Uganda.
wbazeyo@musph.ac.ug.
DOI: 10.1186/s12913-015-0820-5
PMCID: PMC4405852
PMID: 25898973 [Indexed for MEDLINE]
DOI: 10.1002/oby.21600
PMCID: PMC6467537
PMID: 27601085 [Indexed for MEDLINE]
Wilson IB, Fowler FJ Jr, Cosenza CA, Michaud J, Bentkover J, Rana A, Kogelman L,
Rogers WH.
DOI: 10.1007/s10461-013-0610-1
PMCID: PMC4000749
PMID: 24077970 [Indexed for MEDLINE]
Author information:
(1)Belmont University College of Pharmacy, Nashville, Tennessee.
DOI: 10.5688/ajpe80470
PMCID: PMC4891868
PMID: 27293237 [Indexed for MEDLINE]
Author information:
(1)Department of Psychiatry, Myongi Hospital, Hanyang University College of
Medicine.
(2)Department of Psychiatry, Yonsei University College of Medicine.
(3)Department of Psychiatry, Hallym University College of Medicine.
(4)Institute of Behavioral Science in Medicine.
DOI: 10.9758/cpn.2019.17.2.273
PMCID: PMC6478080
PMID: 30905127
Wiecha JM(1), Adams WG(2), Rybin D(3), Rizzodepaoli M(4), Keller J(5), Clay
JM(6).
Author information:
(1)Boston University School of Medicine, 72 East Concord St., B2900, Boston, MA,
02118-2518, USA. john383@bu.edu.
(2)Department of Pediatrics, Boston Medical Center, 1 BMC Place, Boston, MA,
02118, USA. Bill.Adams@bmc.org.
(3)Boston University School of Public Health, 715 Albany St, Boston, MA, 02118,
USA. Rybin@Bu.edu.
(4)Department of Family Medicine, Boston Medical Center, 1 BMC Place, Boston, MA,
02118, USA. Maria.Rizzodepaoli@Bmc.org.
(5)Windsor Street Health Center/Cambridge Health Alliance, 119 Windsor Street,
Cambridge, MA, 02139, USA. jeremyikeller@gmail.com.
(6)Department of Obstetrics and Gynecology, Indiana University School of
Medicine, 340 W 10th St #6200, Indianapolis, IN, 46202, USA. jmurlidh@iu.edu.
DOI: 10.1186/s12890-015-0007-1
PMCID: PMC4355974
PMID: 25885418 [Indexed for MEDLINE]
Corless IB(1), Hoyt AJ(1), Tyer-Viola L(2), Sefcik E(3), Kemppainen J(4),
Holzemer WL(5), Eller LS(5), Nokes K(6), Phillips JC(7), Dawson-Rose C(8),
Rivero-Mendez M(9), Iipinge S(10), Chaiphibalsarisdi P(11), Portillo CJ(8), Chen
WT(12), Webel AR(13), Brion J(14), Johnson MO(15), Voss J(13), Hamilton MJ(16),
Sullivan KM(17), Kirksey KM(18), Nicholas PK(1).
Author information:
(1)1 MGH Institute of Health Professions School of Nursing , Boston,
Massachusetts.
(2)2 Texas Children's Pavillion for Women , Houston, Texas.
(3)3 Texas A&M University-Corpus Christi , Corpus Christi, Texas.
(4)4 University of North Carolina-Wilmington School of Nursing , Wilmington,
North Carolina.
(5)5 Rutgers College of Nursing , Newark, New Jersey.
(6)6 Hunter-Bellevue School of Nursing , CUNY, New York, New York.
(7)7 University of Ottawa , Ottawa, Canada .
(8)8 UCSF School of Nursing , San Francisco, California.
(9)9 University of Puerto Rico , San Juan, Puerto Rico .
(10)10 University of Namibia , Windhoek, Namibia .
(11)11 Faculty of Nursing, Saint Louis College , Bangkok, Thailand .
(12)12 School of Nursing, Yale University , New Haven, Connecticut.
(13)13 Bolton School of Nursing, Case Western University , Cleveland, Ohio.
(14)14 College of Nursing, The Ohio State University , Columbus, Ohio.
(15)15 UCSF , San Francisco, California.
(16)16 Texas A&M University-Corpus Christi , Corpus Christi, Texas.
(17)17 University of Hawaii School of Nursing , Honolulu, Hawaii.
(18)18 Harris Health System , Houston, Texas.
DOI: 10.1089/apc.2017.0009
PMCID: PMC5446604
PMID: 28514193 [Indexed for MEDLINE]
Author information:
(1)Center for Healthcare Delivery Sciences (C4HDS) and Division of
Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and
Women's Hospital and Harvard Medical School, Boston, Massachusetts.
(2)Department of Internal Medicine, Atrius Health, Boston, Massachusetts.
(3)Evidation Health, San Mateo, California.
Erratum in
JAMA Intern Med. 2018 Jun 1;178(6):876.
Comment in
JAMA Intern Med. 2018 Jun 1;178(6):809-811.
DOI: 10.1001/jamainternmed.2018.0447
PMCID: PMC6145760
PMID: 29710289 [Indexed for MEDLINE]
Author information:
(1)Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical
School, Hannover, Germany.
(2)Project Kidney Transplantation 360° (NTX 360°), Hannover Medical School,
Hannover, Germany.
(3)Department of Sports Medicine, Hannover Medical School, Hannover, Germany.
(4)Department of Nephrology and Hypertension, Hannover Medical School, Hannover,
Germany.
(5)Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical
School, Hannover, Germany.
(6)Department of Nephrology and Hypertension, University Hospital Erlangen,
Erlangen, Germany.
Background: Worldwide clinical guidelines for the care of kidney transplant (KT)
recipients recognize the importance of health care providers imparting
appropriate immunosuppressive medication (ISM) information for the facilitation
of safe medication self-management. The extent of medication information made
available is, however, not necessarily what patients require to know about their
prescribed medicines. A useful indicator for determining the quality of
prescription practice is to what degree the provided information meets the
personal needs of patients. No previous studies have focused on the ISM
information needs of KT patients. This study aims to investigate how satisfied KT
patients are with the provided ISM information and to examine the association
between satisfaction levels and socio-demographic, psychosocial, and
transplant-related variables. Materials and Methods: KT patients (n = 440) were
asked to complete a series of self-report questionnaires to evaluate the
variables adherence, ISM experience, perceived social support, symptoms of
anxiety, and depression, and transplant-related information (e.g., donation
type). ISM information needs were assessed with the Satisfaction with Information
about Medicines Scale (SIMS-D). Results: On average, 35.9% of the answers to the
SIMS-D items indicated dissatisfaction with the received information;
dissatisfaction was more prevalent for the SIMS-D subscale "potential problems"
(46.1%) than the SIMS-D subscale "action and usage" (26.7%). On an individual
item level, the dissatisfaction with information concerning ISM side effects on
drowsiness (57.1%) and sex life (56.3%) was most notable. Higher satisfaction
with ISM information was correlated with higher age, better adherence, higher
perceived social support, and lower anxiety levels. Multiple linear regression
analyses revealed that adherence, perceived social support, and age were
independently associated with ISM information satisfaction. No associations were
found with sex, educational level, partnership status, symptoms of depression,
experience of side effects, and transplant-related variables. Discussion: The
data indicate that a substantial proportion of KT patients have unmet ISM
information needs, especially with regard to potential problems of ISM.
Dissatisfaction with ISM information is a potential amendable risk factor for KT
patients engaging in non-adherent behavior, thus justifying further research in
this area. ISM information should be tailored to meet the individual needs of KT
patients in order to promote optimal medication self-management and adherence
behavior.
DOI: 10.3389/fpsyt.2019.00444
PMCID: PMC6609567
PMID: 31316406
1055. Biomed Res Int. 2015;2015:874067. doi: 10.1155/2015/874067. Epub 2015 Oct 11.
Medication Lists and Brown Bag Reviews: Potential Positive and Negative Impacts
on Patients Beliefs about Their Medicine.
Jäger C(1), Steinhaeuser J(2), Freund T(1), Szecsenyi J(1), Goetz K(1).
Author information:
(1)Department of General Practice and Health Services Research, University
Hospital Heidelberg, Voßstraße 2, Geb. 37, 69115 Heidelberg, Germany.
(2)Institute of Family Medicine, University Hospital Schleswig-Holstein, Campus
Lübeck, Ratzeburger Allee 160, Haus 50, 23538 Lübeck, Germany.
DOI: 10.1155/2015/874067
PMCID: PMC4619852
PMID: 26539533 [Indexed for MEDLINE]
Antiretroviral therapy adherence and self-efficacy among people living with HIV
and a history of drug use in Vietnam.
Li L(1), Lin C(1), Lee SJ(1), Tuan LA(2), Feng N(1), Tuan NA(2).
Author information:
(1)1 Semel Institute for Neuroscience and Human Behavior, Center for Community
Health, University of California, Los Angeles, CA, USA.
(2)2 National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
People living with HIV with a history of drug use face additional psychosocial
challenges that could compromise their adherence to antiretroviral therapy (ART).
This study examined ART treatment adherence and adherence self-efficacy among
people living with HIV with a history of drug use in Vietnam. We used
cross-sectional baseline data collected between October 2014 and February 2015
from a randomized controlled trial in Vietnam. Of the 900 persons with a history
of drug use in the trial, a sample of 109 people living with HIV currently on ART
were included in the study. The vast majority (92%) of the participants reported
not missing any medications in the past 30 days. Multiple regression results
indicated that social support was positively associated with adherence
self-efficacy (β = 0.420, P < 0.001) and general adherence to ART (β = 0.201,
P = 0.0368). General adherence to ART was negatively associated with depressive
symptoms (β = -0.188, P = 0.046) and current heroin use (β = -0.196, P = 0.042).
These findings underscore the importance of addressing mental health and social
challenges facing people living with HIV with a history of drug use to promote
ART treatment adherence. Clinical management of HIV should identify and address
concurrent substance use behaviors to maximize adherence and treatment outcomes.
DOI: 10.1177/0956462417696431
PMCID: PMC5494003
PMID: 28632477 [Indexed for MEDLINE]
DOI: 10.1136/openhrt-2018-000877
PMCID: PMC6307606
PMID: 30613409
Oliveira-Filho AD(1), Morisky DE(2), Costa FA(3), Pacheco ST(1), Neves SF(1),
Lyra DP Jr(4).
Author information:
(1)Universidade Federal de Alagoas, Maceió, AL, Brazil.
(2)University of California Los Angeles, Los Angeles, EUA.
(3)Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, AL, Brazil.
(4)Universidade Federal de Sergipe, Aracaju, SE, Brazil.
Comment in
Arq Bras Cardiol. 2015 Jan;104(1):3-4.
DOI: 10.5935/abc.20140151
PMCID: PMC4290741
PMID: 25590930 [Indexed for MEDLINE]
Michetti P(1), Weinman J(2), Mrowietz U(3), Smolen J(4)(5), Peyrin-Biroulet L(6),
Louis E(7), Schremmer D(8), Tundia N(9), Nurwakagari P(10), Selenko-Gebauer
N(11).
Author information:
(1)Crohn and Colitis Centre, Gastro-entérologie La Source-Beaulieu and Division
of Gastroenterology, Centre Hospitalier Universitaire Vaudois, 1004, Lausanne,
Switzerland. pmichetti@gesb.ch.
(2)Institute of Pharmaceutical Sciences, King's College London, London, UK.
(3)Psoriasis-Center at the Department of Dermatology, Venereology and
Allergology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel,
Germany.
(4)Division of Rheumatology, Department of Medicine 3, Medical University of
Vienna, Vienna, Austria.
(5)2nd Department of Medicine, Center for Rheumatic Diseases, Hietzing Hospital,
Vienna, Austria.
(6)Inserm U954 and Department of Gastroenterology, Université de Lorraine,
Vandoeuvre-les-Nancy, France.
(7)CHU de Liège et Université de Liège, Liège, Belgium.
(8)GKM Gesellschaft für Therapieforschung mbH, Munich, Germany.
(9)AbbVie Inc., North Chicago, IL, USA.
(10)Medical Department, AbbVie Deutschland GmbH & Co. KG, Wiesbaden, Germany.
(11)Global Medical Affairs, AbbVie Inc., North Chicago, IL, USA.
Comment in
Adv Ther. 2017 Sep;34(9):2173-2176.
DOI: 10.1007/s12325-016-0441-3
PMCID: PMC5216107
PMID: 27854054 [Indexed for MEDLINE]
Turner AN(1), Maierhofer C(1), Funderburg NT(2), Snyder B(1), Small K(1), Clark
J(1), Bazan JA(1), Kwiek NC(3), Kwiek JJ(4)(5).
Author information:
(1)a Division of Infectious Diseases , College of Medicine, the Ohio State
University , Columbus , OH , USA.
(2)b Division of Medical Laboratory Science , School of Health and Rehabilitation
Sciences, the Ohio State University , Columbus , OH , USA.
(3)c Division of Pharmacology , College of Pharmacy, the Ohio State University ,
Columbus , OH , USA.
(4)d Department of Microbial Infection and Immunity , College of Medicine ,
Columbus , OH , USA.
(5)e Department of Microbiology , College of Arts and Sciences, the Ohio State
University , Columbus , OH , USA.
DOI: 10.1080/09540121.2016.1198746
PMCID: PMC5137247
PMID: 27320493 [Indexed for MEDLINE]
Author information:
(1)Centro de Salud de Nazaret, Departamento de Salud de Valencia Clínic-La
Malvarrosa, Valencia, Spain. sanfelix_jos@gva.es.
(2)Health Services Research Unit, FISABIO, Valencia, Spain. sanfelix_jos@gva.es.
(3)Spanish Network of Chronic Care and Health Services Research (REDISSEC),
Valencia, Spain. sanfelix_jos@gva.es.
(4)Health Research Institute (INCLIVA), Valencia, Spain. sanfelix_jos@gva.es.
(5)Health Services Research Unit, FISABIO, Valencia, Spain.
(6)Spanish Network of Chronic Care and Health Services Research (REDISSEC),
Valencia, Spain.
(7)Health Research Institute (INCLIVA), Valencia, Spain.
DOI: 10.1186/s12875-018-0846-y
PMCID: PMC6154875
PMID: 30249203
Author information:
(1)From the Divisions of General Medicine and Geriatrics and.
(2)Rheumatology, Department of Medicine, Emory University, Atlanta, GA.
OBJECTIVE: African American (AA) people with systemic lupus erythematosus (SLE)
are at high morbidity and mortality risk, and they often require multiple
medications. Low medication adherence is a highly prevalent, multidimensional
problem associated with poor outcomes in people with SLE. Depression, a predictor
of low adherence in people with chronic conditions, has been described in over
35% of AAs with SLE. We hypothesized that depressive symptoms would be
increasingly associated with low adherence in this population.
METHODS: Research subjects predominantly belong to the Georgians Organized
Against Lupus cohort, a population-based cohort of predominantly AA individuals
with SLE in the Atlanta metropolitan area. Medication adherence and severity of
depressive symptoms were measured using validated self-reported tools: the 8-item
Morisky Medication Adherence Scale and the 9-item Patient Health Questionnaire,
respectively. We used univariate and multivariate logistic regression to examine
the odds ratios of low medication adherence across individuals with increasing
severity of depressive symptoms.
RESULTS: Among 632 AA SLE participants, 336 (54%) reported low medication
adherence and 217 (34.6%) reported "moderate" or "severe" depressive symptoms. In
univariate logistic regression, significant risk factors for low adherence were
depressive symptoms, low self-efficacy, poor satisfaction with care, female sex,
younger age, hurried patient-physician communication, poorer shared
decision-making, less compassionate physician communication style, poor/fair
health, and higher disease activity score. In multivariate regression, younger
age, female sex, and more severe depressive symptoms were associated with low
medication adherence.
CONCLUSIONS: This is the first study to examine factors associated with low
medication adherence among a population-based cohort of AA individuals with SLE.
Depression was a strong correlate of low medication adherence. Mental health
interventions aiming to address and treat depression may increase medication
adherence.
DOI: 10.1097/RHU.0000000000000794
PMCID: PMC6487191
PMID: 29912774 [Indexed for MEDLINE]
Thompson D(1), Mackay T(2), Matthews M(2), Edwards J(2), Peters NS(3), Connolly
SB(3).
Author information:
(1)International Centre for Circulatory Health, National Heart and Lung
Institute, Imperial College London, London, United Kingdom.
(2)Imperial College Healthcare NHS Trust, London, United Kingdom.
(3)National Heart and Lung Institute, Imperial College London, London, United
Kingdom.
Erratum in
JMIR Mhealth Uhealth. 2018 Apr 27;6(4):e13.
©David Thompson, Teresa Mackay, Maria Matthews, Judith Edwards, Nicholas Peters,
Susan B Connolly. Originally published in JMIR Mhealth and Uhealth
(http://mhealth.jmir.org), 12.06.2017.
DOI: 10.2196/mhealth.6998
PMCID: PMC5484791
PMID: 28606895
Hong SH(1)(2).
Author information:
(1)Social and Administrative Pharmacy, College of Pharmacy, Seoul National
University, Seoul, Korea.
(2)Research Institute of Pharmaceutical Sciences, Seoul National University,
Seoul, Korea.
Older adults suffering from hypertension form firm medication beliefs through
lifetime medication management, which significantly affect their medication
adherence and treatment outcomes. Understanding whether the patient-physician
communication has the potential to change medication beliefs will help design an
effective communication strategy to foster favorable medication beliefs. This
study aims to determine whether the patient-physician communication is associated
with medication beliefs among older adults with hypertension and controls
socio-demographics and clinical characteristics. Further, it examines how the
association varies with two different types of medication beliefs (medication
overuse and harm) for each domain of communication (informative and
interpersonal). A self-administered cross-sectional survey was conducted for
members of seven senior centers in a metropolitan area of the United States
between August and December of 2013. A total of 211 senior members suffering from
hypertension completed the questionnaire, which included the Primary Care
Assessment Survey (PCAS) and the Beliefs about Medicines Questionnaire (BMQ). The
former had two domains of patient-physician communication-informative and
interpersonal-while the latter measured medication harm and overuse beliefs.
Interpersonal patient-physician communication significantly explained the
medication overuse beliefs (β = -0.28, p < 0.05), whereas neither interpersonal
nor informative communication significantly explained the medication harm
beliefs. Females (β = 1.29, p < 0.01) and participants with higher education (β =
2.66, p = 0.02) more strongly believed that medications are overprescribed.
However, participants with low income more strongly believed that medications are
harmful. Patient-physician communication, if it touches upon interpersonal
aspects, has the potential to change medication overuse beliefs among older
adults with hypertension. Identification of the significant factors which affect
medication beliefs, will inform the design of a patient-centric communication
program that fosters favorable medication beliefs among geriatric hypertensive
patients.
DOI: 10.1371/journal.pone.0210169
PMCID: PMC6322726
PMID: 30615656
Nelson HN(1), Borrero S(2), Lehman E(3), Velott DL(3), Chuang CH(4).
Author information:
(1)Penn State College of Medicine. Electronic address:
hnelson1@pennstatehealth.psu.edu.
(2)Division of General Internal Medicine, University of Pittsburgh; Center for
Health Equity Research and Promotion, VA Pittsburgh Healthcare System.
(3)Department of Public Health Sciences, Penn State College of Medicine.
(4)Division of General Internal Medicine, Penn State College of Medicine;
Department of Public Health Sciences, Penn State College of Medicine.
DOI: 10.1016/j.contraception.2017.08.013
PMCID: PMC6540974
PMID: 28882679 [Indexed for MEDLINE]
The association of tanning behavior with psycho-tropic medication use among young
adult women.
Heckman CJ(1), Munshi T(1), Darlow S(1), Kloss JD(2), Manne SL(3), Perlis C(4),
Oslin D(5).
Author information:
(1)a Cancer Prevention and Control Program , Fox Chase Cancer Center ,
Philadelphia , PA , USA.
(2)b Department of Psychology , Drexel University , 3141 Chestnut St,
Philadelphia , PA 19104 , USA.
(3)c Cancer Prevention and Control Program , Rutgers Cancer Institute of New
Jersey , New Brunswick , NJ , USA.
(4)d Department of Dermatology , Fox Chase Cancer Center , Philadelphia , PA ,
USA.
(5)e Department of Psychiatry , University of Pennsylvania School of Medicine ,
Philadelphia , PA , USA.
Despite its known association with skin cancer, tanning remains popular among
young adult women. Indoor tanning behavior has been found to be associated with
affective and addictive disorders. To better understand potential psychological
and biological mechanisms of tanning behavior, we investigated associations
between tanning and medication (psychotropic and other) use among young women.
Two hundred and fifty-three women age 18-29 years old were recruited from two
northeastern university campus communities. Women self-reported tanning frequency
and chronic medication use. In both univariate and multivariate analyses, indoor
tanning ≥12 times last year was significantly associated with use of psychotropic
medication and anti-depressants in particular. Sunbathing was not associated with
medication use. Potential reasons for associations between tanning and
psychotropic medication use are discussed. Indoor tanners should be warned that
some psychotropic medications are photosensitizing, thus increasing risk for
burns and other skin damage from indoor tanning.
DOI: 10.1080/13548506.2015.1051060
PMCID: PMC4469946
PMID: 26068581 [Indexed for MEDLINE]
Sit JW(1), Chair SY(1), Choi KC(1), Chan CW(1), Lee DT(1), Chan AW(1), Cheung
JL(1), Tang SW(2), Chan PS(2), Taylor-Piliae RE(3).
Author information:
(1)The Nethersole School of Nursing, The Chinese University of Hong Kong, Shatin,
New Territories.
(2)Department of Medicine and Rehabilitation, Tung Wah Eastern Hospital, Hong
Kong Hospital Authority, Causeway Bay, Hong Kong, People's Republic of China.
(3)College of Nursing, The University of Arizona, Tucson, AZ, USA.
DOI: 10.2147/CIA.S109560
PMCID: PMC5072569
PMID: 27789938 [Indexed for MEDLINE]
Eva JJ(1), Kassab YW(2), Neoh CF(1)(3), Ming LC(4)(5), Wong YY(6), Abdul Hameed
M(1), Hong YH(7), Sarker MMR(8).
Author information:
(1)Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Malaysia.
(2)Faculty of Pharmacy, Cyberjaya University College of Medical Sciences,
Cyberjaya, Malaysia.
(3)Collaborative Drug Discovery Research Group, Pharmaceutical and Life Sciences
Community of Research, Universiti Teknologi MARA, Shah Alam, Malaysia.
(4)School of Pharmacy, KPJ Healthcare University College, Negeri Sembilan,
Malaysia.
(5)Pharmacy, School of Medicine, University of Tasmania, Hobart, TAS, Australia.
(6)Faculty of Pharmacy, Universiti Teknologi MARA, Bertam, Malaysia.
(7)Department of Physiology, Faculty of Medicine, University of Malaya, Kuala
Lumpur, Malaysia.
(8)Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh.
DOI: 10.3389/fendo.2018.00489
PMCID: PMC6232899
PMID: 30459707
Nagasawa H(1)(2), Tachi T(2), Sugita I(2), Esaki H(2), Yoshida A(2), Kanematsu
Y(2), Noguchi Y(2), Kobayashi Y(3), Ichikawa E(4), Tsuchiya T(2)(5), Teramachi
H(2)(6).
Author information:
(1)Department of Pharmacy, Secomedic Hospital, Funabashi, Japan.
(2)Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Gifu, Japan.
(3)Department of Pharmacy, Chiba Central Medical Center, Chiba, Japan.
(4)Department of Pharmacy, Chuno Kosei Hospital, Gifu, Japan.
(5)Community Health Support and Research Center, Gifu, Japan.
(6)Laboratory of Community Healthcare Pharmacy, Gifu Pharmaceutical University,
Gifu, Japan.
Dialysis treatment is known to lead to reduced quality of life (QOL) among
patients. This decreased QOL is believed to influence medication compliance,
although this effect has not yet been clarified. In this study, we investigated
whether decreased QOL due to dialysis treatment does in fact influence medication
compliance. Participants were 92 patients who self-managed their medication and
were receiving dialysis treatment at Secomedic Hospital or Chiba Central Medical
Center. We surveyed their age, sex, dialysis period, and medication management
situation, and administered the EQ-5D and Kidney Disease Quality of Life
Instrument-Short Form. A multiple logistic regression analysis with medication
compliance as the dependent variable and QOL as the independent variable was
conducted. The recovery rate and effective response rate were both 100%. The
results indicated that patients with good sleep QOL (mean or above) had higher
odds of medication compliance (odds ratio, 3.36; 95% confidence interval,
1.26-8.96; P = 0.016). Therefore, improving the quality of sleep of dialysis
patients might help to improve their medication compliance.
DOI: 10.3389/fphar.2018.00488
PMCID: PMC6008555
PMID: 29950988
Author information:
(1)University of Auckland, Auckland, New Zealand.
DOI: 10.2337/diaspect.28.4.252
PMCID: PMC4647176
PMID: 26600726
Foster JM(1), Reddel HK(2), Usherwood T(3), Sawyer SM(4), Smith L(5).
Author information:
(1)Woolcock Institute of Medical Research, University of Sydney, Sydney,
Australia. Electronic address: j.m.foster@woolcock.org.au.
(2)Woolcock Institute of Medical Research, University of Sydney, Sydney,
Australia. Electronic address: helen.reddel@sydney.edu.au.
(3)Department of General Practice, Sydney Medical School - Westmead, University
of Sydney, Sydney, Australia; George Institute for Global Health, Sydney,
Australia. Electronic address: tim.usherwood@sydney.edu.au.
(4)Centre for Adolescent Health, Royal Children's Hospital Melbourne, Melbourne,
Australia; Department of Paediatrics, The University of Melbourne, Melbourne,
Australia; Murdoch Childrens Research Institute, Melbourne, Australia. Electronic
address: susan.sawyer@rch.org.au.
(5)Faculty of Pharmacy, University of Sydney, Sydney, Australia. Electronic
address: lorraine.smith@sydney.edu.au.
DOI: 10.1016/j.rmed.2017.05.013
PMID: 28732834 [Indexed for MEDLINE]
Borba AKOT(1), Marques APO(1), Ramos VP(1), Leal MCC(1), Arruda IKG(1), Ramos
RSPDS(1).
Author information:
(1)Programa de Pós-Graduação em Enfermagem, Centro de Ciências da Saúde,
Universidade Federal de Pernambuco. Campus Universitário, Cidade Universitária.
50670-901 Recife PE Brasil. anninhatito@gmail.com.
This study aimed to investigate factors associated with the treatment adherence
of 150 elderly diabetics assisted in gerontogeriatric outpatient service in
northeastern Brazil. Full adherence to therapy was self-reported by 27.3% of the
elderly. In the bivariate analysis, adherence was associated with self-perceived
health, beliefs in the use of medication, understanding explanations about
diabetes and professional responsible for treatment guidance. After analysis
adjustment, only beliefs in medicine were significant when comparing
non-adherence with full adherence (OR = 9.65; CI95% 1.6; 56.6) and non-adherence
with partial adherence (OR = 18.15; CI95% 3.5;95.4). It can be concluded that
full adherence to diabetes treatment is low and is associated with beliefs in
medications for disease control. It is necessary to develop additional studies to
better define the role of health beliefs and practices of care among elderly
assisted in primary health care.
Author information:
(1)Department of Pharmacology, College of Medicine and Health Sciences,
University of Gondar, Gondar, Ethiopia.
(2)Department of Clinical Pharmacy, College of Medicine and Health Sciences,
University of Gondar, Gondar, Ethiopia.
DOI: 10.1155/2017/4530183
PMCID: PMC5368397
PMID: 28393101 [Indexed for MEDLINE]
Author information:
(1)Department of Psychiatry, Ahmadu Bello University Teaching Hospital, Zaria,
Nigeria.
DOI: 10.4103/1119-3077.151753
PMID: 25772921 [Indexed for MEDLINE]
Martel MO(1), Finan PH, Dolman AJ, Subramanian S, Edwards RR, Wasan AD, Jamison
RN.
Author information:
(1)aDepartment of Anesthesiology, Harvard Medical School, Brigham and Women's
Hospital Pain Management Center, Chestnut Hill, MA, USA bDepartment of Psychiatry
and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore,
MD, USA cDepartment of Social and Behavioral Sciences, Harvard School of Public
Health, Boston, MA, USA dUPMC Pain Medicine, Departments of Anesthesiology and
Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
The primary purpose of this study was to examine the association between
self-reports of medication side effects and pain-related activity interference in
patients with chronic pain. The potential moderators of the association between
reports of side effects and pain-related activity interference were also
examined. A total of 111 patients with chronic musculoskeletal pain were asked to
provide, once a month for a period of 6 months, self-reports of medication use
and the presence of any perceived side effects (eg, nausea, dizziness, headaches)
associated with their medications. At each of these time points, patients were
also asked to provide self-reports of pain intensity, negative affect, and
pain-related activity interference. Multilevel modeling analyses revealed that
month-to-month increases in perceived medication side effects were associated
with heightened pain-related activity interference (P < 0.05). Importantly,
multilevel models revealed that perceived medication side effects were associated
with heightened pain-related activity interference even after controlling for the
influence of patient demographics, pain intensity, and negative affect. This
study provides preliminary evidence that reports of medication side effects are
associated with heightened pain-related activity interference in patients with
chronic pain beyond the influence of other pain-relevant variables. The
implications of our findings for clinical practice and the management of patients
with chronic pain conditions are discussed.
DOI: 10.1097/j.pain.0000000000000154
PMCID: PMC4431924
PMID: 25782367 [Indexed for MEDLINE]
1076. Eur J Pain. 2018 Jan;22(1):28-38. doi: 10.1002/ejp.1068. Epub 2017 Aug 14.
Weiser T(1), Richter E(2), Hegewisch A(3), Muse DD(4), Lange R(5).
Author information:
(1)Medical Affairs Consumer Health Care, Medical and Regulatory Affairs Germany,
Boehringer Ingelheim Pharma GmbH & Co. KG, Germany.
(2)Corporate Division Medicine, Global Department Biostatistics and Data
Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Germany.
(3)Marketing Self-Medication, Global Department Consumer Health Care Division
Medical and Regulatory Affairs, Boehringer Ingelheim, Promeco S.A. de C.V,
Germany.
(4)Jean Brown Research, Salt Lake City, USA.
(5)Consumer Health Care Development, Medical and Regulatory Affairs, Boehringer
Ingelheim Pharma GmbH & Co. KG, Germany.
BACKGROUND: Ibuprofen is an effective analgesic treatment with a ceiling effect
at doses above 400 mg. This study compared the combination of ibuprofen 400 mg
and caffeine 100 mg with ibuprofen 400 mg monotherapy, caffeine and placebo in
the analgesic treatment of moderate to severe acute dental pain following third
molar extraction.
METHODS: Phase III, active-/placebo-controlled, double-blind, single-centre,
two-stage, parallel-group study in adult patients with at least moderate baseline
pain intensity. Primary endpoint was defined as the time-weighted sum of pain
relief and pain intensity difference over 8 h (SPRID0-8 h), secondary endpoints
included duration of pain relief, time to meaningful pain relief and more.
RESULTS: N = 748 patients were enrolled and N = 562 treated. Mean baseline pain
intensity was 7.7 on a 0-10 numerical rating scale. Analysis of SPRID0-8 h
demonstrated superior analgesic effects for a single dose of ibuprofen/caffeine
versus ibuprofen, caffeine and placebo over 8 h, rescue medication in this stage
was requested by more patients on ibuprofen (32.5%) than on ibuprofen/caffeine
(16.0%). Median time to meaningful pain relief was shorter for ibuprofen/caffeine
(1.13 h) compared with ibuprofen (1.78 h; p = 0.0001). More patients on
ibuprofen/caffeine than on ibuprofen reported meaningful pain relief. Adverse
events were infrequent and mostly mild or moderate across treatment groups.
Tolerability was rated as 'very good' or 'excellent' by most patients in both
treatment groups.
CONCLUSION: This study demonstrated clinically relevant superiority of
ibuprofen/caffeine over monotherapy with ibuprofen in patients with acute dental
pain. All treatments were well tolerated.
SIGNIFICANCE: This trial showed superior efficacy of 400/100 mg
ibuprofen/caffeine, compared to 400 mg ibuprofen alone, for treating acute pain,
reflecting that caffeine is an effective analgesic adjuvant. Data on efficacy of
400 mg ibuprofen combined with caffeine for the treatment of acute pain were not
available yet.
© 2017 The Authors. European Journal of Pain published by John Wiley & Sons Ltd
on behalf of European Pain Federation - EFIC®.
DOI: 10.1002/ejp.1068
PMCID: PMC5763370
PMID: 28805281 [Indexed for MEDLINE]
Molugulu N(1), Gubbiyappa KS(2), Vasudeva Murthy CR(3), Lumae L(4), Mruthyunjaya
AT(5).
Author information:
(1)Department of Pharmaceutical Technology, School of Pharmacy, Bukit Jalil,
Kuala Lumpur 57000, Malaysia.
(2)Department of Life Sciences, School of Pharmacy, International Medical
University, Bukit Jalil, Kuala Lumpur 57000, Malaysia.
(3)Department of Pathology, School of Medicine, International Medical University,
Bukit Jalil, Kuala Lumpur 57000, Malaysia.
(4)Department of Pharmaceutics, Faculty of Pharmacy, Asia Metropolitan
University, 43200 Cheras, Selangor, Malaysia.
(5)Department of Pharmacy Practice, School of Pharmacy, International Medical
University, Bukit Jalil, Kuala Lumpur 57000, Malaysia.
INTRODUCTION: Reports on medication adherence and its associated factors in
patients with epilepsy in South East Asian countries are lacking. The primary
purpose of this study was to assess the degree of medication adherence and its
relationship with patient's satisfaction, psychosocial factors, quality of life
and mental health in a sample of Malaysian epilepsy patients.
METHODOLOGY: It is a cross-sectional study and was carried out in the outpatient
Neurology Department of Hospital Kuala Lumpur, Malaysia (n=272). Data was
collected by administering the structured questionnaire.
RESULTS AND DISCUSSION: Results showed that 49.3% of the epilepsy patients were
non-adherent to their prescribed regimen. Univariate analysis showed significant
associations between medication adherence and the following factors: race,
seizure frequency, overall patient satisfaction, medication taste and smell,
medication cost and physical appearance, medication effectiveness, complexity of
medication regimen, patient barrier, patient understanding, patient role
functioning, patient positivity, vitality and general interest. Multiple
regression analysis indicated that factors that are influencing medication
adherence are seizure frequency (P = 0.048), overall patient satisfaction (P =
0.043) and patient understanding about their illness (P = 0.001). The model
chosen for testing the relationship between medication adherence and its
associated factors give an R2 value of 25.2% with an adjusted R2 of 21.4%. The F
value was also significant (P = 0.000). Based on the research findings, the
researchers recommends that clinicians need to play a vital role in educating the
patients on their disease conditions. By educating the patients on nature of
epilepsy, different modalities of treatment and benefits of adherence to
treatment will help in the better adherence and management.
DOI: 10.4103/0976-0105.189430
PMCID: PMC5153886
PMID: 27999469
1078. BMC Health Serv Res. 2017 Mar 16;17(1):213. doi: 10.1186/s12913-017-2142-2.
Author information:
(1)Public Health and Primary Care Department, Leiden Universitair Medisch Centrum
(LUMC), P.O. Box 9600, Leiden, 2300 RC, The Netherlands. e.talboom@saltro.nl.
(2)Saltro Diagnostic Centre, P.O. Box 9300, Utrecht, 3506 GH, The Netherlands.
e.talboom@saltro.nl.
(3)Public Health and Primary Care Department, Leiden Universitair Medisch Centrum
(LUMC), P.O. Box 9600, Leiden, 2300 RC, The Netherlands.
(4)Saltro Diagnostic Centre, P.O. Box 9300, Utrecht, 3506 GH, The Netherlands.
(5)Foundation Zorgdraad, Wijnand van Arnhemweg 54, Oosterbeek, 6862XN, The
Netherlands.
DOI: 10.1186/s12913-017-2142-2
PMCID: PMC5356357
PMID: 28302116 [Indexed for MEDLINE]
Karmakar M(1), Pinto SL(2), Jordan TR(1), Mohamed I(3), Holiday-Goodman M(2).
Author information:
(1)School of Population Health, University of Toledo, Toledo, Ohio, USA.
(2)Department of Pharmacy Practice, University of Toledo, Toledo, Ohio, USA.
(3)Department of Medicine, University of Toledo, Toledo, Ohio, USA.
DOI: 10.1177/1178223417694520
PMCID: PMC5391055
PMID: 28469437
Holistic care program for elderly patients to integrate spiritual needs, social
activity, and self-care into disease management in primary care (HoPES3): study
protocol for a cluster-randomized trial.
Author information:
(1)Department of General Practice and Health Services Research, University
Hospital Heidelberg, Im Neuenheimer Feld 130.3, 69120, Heidelberg, Germany.
cornelia.strassner@med.uni-heidelberg.de.
(2)Department of Psychosomatic Medicine and Psychotherapy, Research Center
Spiritual Care, Technical University of Munich, Langerstr. 3, 81675, München,
Germany.
(3)Department of General Practice and Health Services Research, University
Hospital Heidelberg, Im Neuenheimer Feld 130.3, 69120, Heidelberg, Germany.
(4)Department for Medical Biometry, Institute for Medical Biometry and
Informatics, University Hospital Heidelberg, Im Neuenheimer Feld 130.3, 69120,
Heidelberg, Germany.
(5)Institute of General Practice and Interprofessional Care, University Hospital
Tübingen, Osianderstr. 5, 72076, Tübingen, Germany.
DOI: 10.1186/s13063-019-3435-z
PMCID: PMC6582494
PMID: 31215468
Chang J(1), Lizer A(2), Patel I(3), Bhatia D(4), Tan X(5), Balkrishnan R(6).
Author information:
(1)Humana - Comprehensive Health Insights, Louisville, USA.
(2)Bernard J. Dunn School of Pharmacy, Shenandoah University, Winchester, USA.
(3)Department of Biopharmaceutical Sciences, Shenandoah University, Winchester,
USA.
(4)Department of Pharmacogenomics, Shenandoah University, Ashburn, USA.
(5)Department of Pharmaceutical Systems and Policy, West Virginia University,
Morgantown, USA.
(6)Department of Public Health Sciences, University of Virginia, Charlottsville,
USA.
As the role of the pharmacist becomes more patient and counseling-centered, the
healthcare market is changing to keep pace with more modern needs, such as
self-treatment. Self-treatment provides patients the ability to diagnose their
own condition and pick an appropriate medication from the pharmacy to treat their
symptoms. This process allows a certain freedom for consumers to actively engage
in their own health. In order for patients to self-treat, access to
over-the-counter (OTC) medication is of prime importance. Many medications that
are available as OTC today were previously labeled as prescription medications.
As more safety studies and trials are conducted for different drugs, they can be
deemed appropriate for use without a prescription. This review study discusses
the process of switching of prescription medications to OTC medications in the
United States and the implications of switching on patients, practitioners, drug
makers, and insurers.
DOI: 10.4103/2279-042X.185706
PMCID: PMC4966231
PMID: 27512703
Pellowski JA, Kalichman SC, White D, Amaral CM, Hoyt G, Kalichman MO.
DOI: 10.1016/j.jana.2014.06.002
PMCID: PMC4194222
PMID: 25043931 [Indexed for MEDLINE]
Knowledge and practice assessment, and self reported barriers to guideline based
asthma management among doctors in Nigeria.
Ozoh OB(1), Ndukwu CI(2), Desalu OO(3), Adeyeye OO(4), Adeniyi B(5).
Author information:
(1)Department of Medicine, College of Medicine, University of Lagos, Lagos State,
Nigeria.
(2)Department of Paediatrics, Faculty of Medicine, Nnamdi Azikiwe University,
Awka, Nigeria.
(3)Department of Medicine, College of Medicine, University of Ilorin, Kwara
State, Nigeria.
(4)Department of Medicine, Lagos State University College of Medicine, Lagos
State, Nigeria.
(5)Department of Medicine, Federal Medical Center, Owo, Osun State, Nigeria.
DOI: 10.4103/njcp.njcp_569_18
PMID: 31089025 [Indexed for MEDLINE]
Living under treatment for Systemic Hypertension and Diabetes Mellitus: Feelings
and behaviors.
Author information:
(1)Prefeitura de Matozinhos. Matozinhos, Minas Gerais, Brazil.
(2)Universidade Federal de São João Del-Rei. Divinópolis, Minas Gerais, Brazil.
OBJECTIVE: To understand the feelings and behaviors of people being treated for
Systemic Hypertension (SH) and Diabetes Mellitus (DM).
METHOD: A qualitative study based on Grounded Theory and Symbolic Interactionism,
with 27 participants in treatment for SH and DM followed up by the Family Health
Strategy team. Open, axial and selective coding was performed, giving rise to
three theoretical categories and the central category.
RESULTS: The daily life is explicit in the (lack of)care of the self with the
chronic disease and feelings of sadness and anxiety are expressed as reasons for
the lack of control of the disease. It points out that people take care of
themselves because of fear of complications, reinforced the need for guidance on
the use of medication and the empowerment of the chronic patient for self-care
and care for the other.
FINAL CONSIDERATIONS: Knowing behaviors and feelings of people with SH and/or DM
allows a professional performance beyond the chronic condition.
DOI: 10.1590/0034-7167-2016-0500
PMID: 30916274 [Indexed for MEDLINE]
Bailey SC(1), Annis IE(1), Reuland DS(2), Locklear AD(1), Sleath BL(1), Wolf
MS(3).
Author information:
(1)Division of Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy,
University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
(2)Department of Medicine, Division of General Internal Medicine and Clinical
Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
(3)Health Literacy and Learning Program, Division of General Internal Medicine,
Feinberg School of Medicine at Northwestern University, Chicago, IL, USA.
BACKGROUND: Current adherence scales often fail to assess the full spectrum of
behaviors associated with safe and appropriate drug use and may be unsuitable for
patients with limited health literacy. We sought to develop and evaluate a
comprehensive yet brief Measure of Drug Self-Management (MeDS) for use in
research and clinical settings among diverse patient groups.
METHODS: Expert opinion, literature reviews, and interviews with patients and
providers were utilized to create and revise potential items. Item performance
testing was then conducted among 193 adult English-speaking patients with
hypertension and diabetes. Factor analysis was used to inform item selection.
Reliability was assessed via calculations of internal consistency. To assess
construct and predictive validity, MeDS scores were compared with scores from the
8-item Morisky Medication Adherence Scale and relevant clinical measures (HbA1c,
blood pressure, and low-density lipoprotein cholesterol).
RESULTS: The MeDS demonstrated adequate internal consistency with a Cronbach's α
of 0.72. The MeDS was significantly correlated with the Morisky Medication
Adherence Scale (r= -0.62; P<0.001). The MeDS was also associated with clinical
measures, with statistically significant correlations found between MeDS scores
and low-density lipoprotein cholesterol (r= -0.27, P≤0.001) and diastolic blood
pressure (r= -0.18, P=0.01).
CONCLUSION: The MeDS seems to be a valid and reliable tool that can be used to
assess medication self-management skills among diverse patients, including those
with limited literacy skills. Future studies are needed to test the tool in
actual use and explore clinical applications.
DOI: 10.2147/PPA.S85411
PMCID: PMC4527367
PMID: 26257515
Author information:
(1)Department of Geriatric Medicine, Division of Population Medicine, Cardiff
University, Cardiff, UK Institute of Cardiovascular and Medical Sciences, College
of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
(2)Institute of Cardiovascular and Medical Sciences, College of Medical,
Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://www.bmj.com/company/products-services/rights-and-licensing/
DOI: 10.1136/bmjopen-2015-009161
PMCID: PMC4809076
PMID: 27006341 [Indexed for MEDLINE]
1087. Psychiatr Serv. 2016 Jul 1;67(7):803-6. doi: 10.1176/appi.ps.201400568. Epub
2016
Feb 14.
Author information:
(1)Dr. Leggett, Dr. Zivin, and Dr. Valenstein are with the Department of
Psychiatry, University of Michigan Medical School, Ann Arbor (e-mail:
leggetta@med.umich.edu ). Dr. Zivin and Dr. Valenstein are also with the Center
for Clinical Management Research, U.S. Department of Veterans Affairs, Ann Arbor,
Michigan, where Ms. Ganoczy is affiliated.
DOI: 10.1176/appi.ps.201400568
PMCID: PMC5796766
PMID: 26876656 [Indexed for MEDLINE]
Butler MJ(1), Tanner RM(2), Muntner P(2), Shimbo D(3), Bress AP(4), Shallcross
AJ(5), Sims M(6), Ogedegbe G(5), Spruill TM(5).
Author information:
(1)Department of Population Health, NYU School of Medicine, New York, NY, USA.
Electronic address: mark.butler@nyumc.org.
(2)Department of Epidemiology, University of Alabama at Birmingham, Birmingham,
AL, USA.
(3)Department of Medicine, Columbia University Medical Center, New York, NY, USA.
(4)Department of Population Health Sciences, University of Utah, Salt Lake City,
UT, USA.
(5)Department of Population Health, NYU School of Medicine, New York, NY, USA.
(6)Department of Medicine, University of Mississippi Medical Center, Jackson, MS,
USA.
The purpose of this study was to test the association between a self-report
measure of 24-hour adherence to antihypertensive medication and blood pressure
(BP) among African Americans. The primary analysis included 3558 Jackson Heart
Study participants taking antihypertensive medication who had adherence data for
at least one study examination. Nonadherence was defined by self-report of not
taking one or more prescribed antihypertensive medications, identified during
pill bottle review, in the past 24 hours. Nonadherence and clinic BP were
assessed at Exam 1 (2000-2004), Exam 2 (2005-2008), and Exam 3 (2009-2013).
Associations of nonadherence with clinic BP and uncontrolled BP (systolic
BP ≥ 140 mm Hg or diastolic BP ≥ 90 mm Hg) were evaluated using unadjusted and
adjusted linear and Poisson repeated measures regression models. The prevalence
of nonadherence to antihypertensive medications was 25.4% at Exam 1, 28.7% at
Exam 2, and 28.5% at Exam 3. Nonadherence was associated with higher systolic BP
(3.38 mm Hg) and diastolic BP (1.47 mm Hg) in fully adjusted repeated measures
analysis. Nonadherence was also associated with uncontrolled BP (prevalence
ratio = 1.26; 95% confidence interval = 1.16-1.37). This new self-report measure
may be useful for identifying nonadherence to antihypertensive medication in
future epidemiologic studies.
DOI: 10.1016/j.jash.2017.06.011
PMCID: PMC5603252
PMID: 28895842 [Indexed for MEDLINE]
1089. J Gen Fam Med. 2018 Nov 20;20(1):19-24. doi: 10.1002/jgf2.219. eCollection
2019
Jan.
Author information:
(1)Matsumura Clinic Tokyo Japan.
(2)Department of Clinical Epidemiology National Hospital Organization Tokyo
Medical Center Tokyo Japan.
(3)Center for Education & Research on Clinical Pharmacy Showa Pharmaceutical
University Tokyo Japan.
(4)Department of Healthcare Epidemiology , Graduate School of Medicine and Public
Health Kyoto University Kyoto Japan.
Background: The aim of this study was to examine whether or not the type of
physician is associated with the knowledge of and adherence to hypertensive
medication among patients.
Methods: The study was a self-administered questionnaire survey among patients
who submitted their prescriptions for antihypertensive drugs to 13 pharmacies in
Japan in 2006. We compared patients' knowledge of their medications and the
self-reported adherence according to the type of physician.
Results: A total of 736 patients were surveyed, and 687 (362 from clinics and 325
from hospitals) were analyzed. In total, 51.8% of the patients correctly named
their antihypertensive medicine, with no significant differences observed between
clinics and hospitals (51.4% in clinics vs 52.3% in hospitals; P = 0.81, adjusted
odds ratio (OR) to the hospital: 0.736, 95% confidence interval [CI]: 0.50-1.08).
Significant differences were not observed in the knowledge of the frequency with
which hypertensive medication was supposed to be taken (47.2% in clinics vs 46.5%
in hospitals; P = 0.84, adjusted OR: 0.80, 95% CI: 0.55-1.16), nor observed in
the knowledge of the side effects of the medication (53.2% in clinics vs 51.0% in
hospitals; P = 0.57, adjusted OR: 1.14, 95% CI: 0.78-1.68). No significant
difference was observed in self-reported adherence (75.1% in clinics vs 77.7% in
hospitals; P = 0.42, adjusted OR: 0.73, 95% CI: 0.46-1.16).
Conclusions: About 75% answered that they were taking their medication as
instructed. No significant differences were observed in responses based on the
physician's affiliation. Further studies are needed to achieve better patient's
adherence and pharmaceutical knowledge.
DOI: 10.1002/jgf2.219
PMCID: PMC6321828
PMID: 30631655
1090. Pharmacy (Basel). 2019 Jun 17;7(2). pii: E66. doi: 10.3390/pharmacy7020066.
Author information:
(1)Apple Discount Drugs, Salisbury, MD 21804, USA. geoff@appledrugs.com.
(2)School of Pharmacy, University of Maryland Eastern Shore, Princess Anne, MD
21853, USA. tdavid@umes.edu.
(3)School of Pharmacy, University of Maryland Eastern Shore, Princess Anne, MD
21853, USA. jtaylor4@umes.edu.
For years many pharmacists have been performing 'brown bag' medication reviews
for patients. While most pharmacists and student pharmacists are familiar with
this process, it is important to determine the value patients receive from this
service. Over the course of this study the authors attempted to modernize the
medication reconciliation process and collect data on patient prescription drug
and over-the-counter drug use, along with quantifying the types of interventions
the pharmacy's clinical staff performed for patients during this process. The
pharmacy partnered with a Quality Improvement Organization to trial their Blue
Bag Intervention (BBI) program. The BBI program offered several additional
services to the traditional brown bag review. The BBI was instituted as a
follow-up tool in the pharmacy's diabetes self-management education/training
clinic to aid in patient follow-up and help the clinical staff identify
medication-related events such as medication adherence issues and drug-drug
interactions. The clinical staff identified approximately 2.2 events per patient
with over 50% being issues that affected patient safety.
DOI: 10.3390/pharmacy7020066
PMCID: PMC6631051
PMID: 31212922
DOI: 10.1186/s12978-017-0374-6
PMCID: PMC5585984
PMID: 28874178 [Indexed for MEDLINE]
Author information:
(1)Laval University Faculty of Pharmacy, Québec, QC, Canada.
DOI: 10.1016/j.jval.2014.08.079
PMID: 27202609
1093. Rev Bras Enferm. 2018 Nov-Dec;71(6):3006-3012. doi: 10.1590/0034-7167-2018-
0087.
Author information:
(1)Universidade Federal do Ceará. Fortaleza, Ceará, Brazil.
DOI: 10.1590/0034-7167-2018-0087
PMID: 30517405 [Indexed for MEDLINE]
Author information:
(1)Pharmaceutical Care Research Group, Department of Pharmaceutical Sciences,
University of Basel, Basel, Switzerland.
(2)Institute of Hospital Pharmacy, Solothurner Spitäler, Olten, Switzerland.
(#)Contributed equally
© Article author(s) (or their employer(s) unless otherwise stated in the text of
the article) 2018. All rights reserved. No commercial use is permitted unless
otherwise expressly granted.
DOI: 10.1136/bmjopen-2017-016610
PMCID: PMC5855403
PMID: 29523558 [Indexed for MEDLINE]
How do mobile phone diabetes programs drive behavior change? Evidence from a
mixed methods observational cohort study.
Nundy S(1)(2), Mishra A(1), Hogan P(1), Lee SM(3), Solomon MC(4), Peek
ME(3)(5)(6).
Author information:
(1)Department of Medicine, University of Chicago Medical Center, Chicago,
Illinois (Dr Nundy, Ms Mishra, Mr Hogan, Dr Peek)
(2)Chicago Center for Diabetes Translation Research, Chicago, Illinois (Dr Nundy,
Dr Peek)
(3)Department of Health Studies, University of Chicago, Chicago, Illinois (Dr
Lee)
(4)Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois
(Ms Solomon)
(5)Center for Health and Social Sciences, University of Chicago, Chicago,
Illinois (Dr Peek)
(6)Center for the Study of Race, Politics and Culture, University of Chicago,
Chicago, Illinois (Dr Peek)
PURPOSE: The purpose of this study was to investigate the behavioral effects of a
theory-driven, mobile phone-based intervention that combines automated text
messaging and remote nursing, using an automated, interactive text messaging
system.
METHODS: This was a mixed methods observational cohort study. Study participants
were members of the University of Chicago Health Plan (UCHP) who largely reside
in a working-class, urban African American community. Surveys were conducted at
baseline, 3 months (mid-intervention), and 6 months (postintervention) to test
the hypothesis that the intervention would be associated with improvements in
self-efficacy, social support, health beliefs, and self-care. In addition,
in-depth individual interviews were conducted with 14 participants and then
analyzed using the constant comparative method to identify new behavioral
constructs affected by the intervention.
RESULTS: The intervention was associated with improvements in 5 of 6 domains of
self-care (medication taking, glucose monitoring, foot care, exercise, and
healthy eating) and improvements in 1 or more measures of self-efficacy, social
support, and health beliefs (perceived control). Qualitatively, participants
reported that knowledge, attitudes, and ownership were also affected by the
program. Together these findings were used to construct a new behavioral model.
CONCLUSIONS: This study's findings challenge the prevailing assumption that
mobile phones largely affect behavior change through reminders and support the
idea that behaviorally driven mobile health interventions can address multiple
behavioral pathways associated with sustained behavior change.
DOI: 10.1177/0145721714551992
PMCID: PMC4492449
PMID: 25278512 [Indexed for MEDLINE]
Medication History Lab and Assessment using the Medication Mysteries Infinite
Case Tool.
Author information:
(1)Clinical Assistant Professor, Department of Pharmacotherapy and Translational
Research, University of Florida College of Pharmacy.
(2)Assistant Professor, Department of Pharmacy Practice, Philadelphia College of
Osteopathic Medicine.
(3)Laboratory Facilitator, Department of Pharmacotherapy and Translational
Research, University of Florida College of Pharmacy.
DOI: 10.15766/mep_2374-8265.10519
PMCID: PMC6440429
PMID: 30984861
Relationship Between Patients' Perceptions of Care Quality and Health Care Errors
in 11 Countries: A Secondary Data Analysis.
Author information:
(1)James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati,
Ohio (Drs Hincapie and MacKinnon); and College of Pharmacy, University of
Arizona, Tucson (Drs Slack, Malone, and Warholak).
Patients may be the most reliable reporters of some aspects of the health care
process; their perspectives should be considered when pursuing changes to improve
patient safety. The authors evaluated the association between patients' perceived
health care quality and self-reported medical, medication, and laboratory errors
in a multinational sample. The analysis was conducted using the 2010 Commonwealth
Fund International Health Policy Survey, a multinational consumer survey
conducted in 11 countries. Quality of care was measured by a multifaceted
construct developed using Rasch techniques. After adjusting for potentially
important confounding variables, an increase in respondents' perceptions of care
coordination decreased the odds of self-reporting medical errors, medication
errors, and laboratory errors (P < .001). As health care stakeholders continue to
search for initiatives that improve care experiences and outcomes, this study's
results emphasize the importance of guaranteeing integrated care.
DOI: 10.1097/QMH.0000000000000079
PMCID: PMC4721215
PMID: 26783863 [Indexed for MEDLINE]
1098. Iran Red Crescent Med J. 2016 Apr 30;18(5):e25183. doi: 10.5812/ircmj.25183.
eCollection 2016 May.
Author information:
(1)Health Information Management Department, School of Management and Medical
Information Sciences, Iran University of Medical Sciences, Tehran, IR Iran.
(2)Medical Informatics Research Center, Institute of Futures Studies in Health,
Kerman University of Medical Sciences, Kerman, IR Iran.
DOI: 10.5812/ircmj.25183
PMCID: PMC4939231
PMID: 27437126
Author information:
(1)Department of Clinical Nursing, Faculty of Health Sciences, Wroclaw Medical
University, Wroclaw, Poland.
(2)Cardiology Department, Centre for Heart Diseases, Military Hospital, Wroclaw,
Poland.
(3)Department of Community Health Sciences, UCLA Fielding School of Public
Health, Los Angeles, CA, United States.
Background: The aim of this systematic review and meta-analysis was to estimate
medication adherence in hypertensive patients aged ≥60 years and to explore
potential determinants of adherence with antihypertensive treatment in this age
group. Methods: A systematic search of the PubMed, Scopus, and Google Scholar
using the Cochrane guidelines was performed. The analysis included articles
published between 1 January 2000 and 30 June 2018. The patients were considered
adherent if they scored ≥6 pts. on the Morisky Medication Adherence Scale
(MMAS-8) or ≥3 pts. on the Morisky Green Levine Medication Adherence Scale (MGL).
If available, also odds ratios (OR) with 95% confidence intervals (95% CI) for
determinants of medication adherence were recorded. Results: Thirteen studies
including a total of 5,247 patients were available for the meta-analysis. The
pooled percentage of adherence was 68.86% (95% CI: 57.80-79.92%). Subgroup
analysis did not demonstrate a significant difference in the adherence measured
with the MMAS-8 and the MGL (68.31 vs. 70.39%, P = 0.773). The adherence of
patients from Western countries (Europe, United States) turned out to be
significantly higher than in other patients (83.87 vs. 54.30%, P = 0.004). The
significant determinants of better adherence identified in more than one study
were older age, retirement/unemployment, duration of hypertension >10 years, and
a lower number of prescribed drugs. Conclusion: Medication adherence in the
oldest old hypertensive patients seems to be higher than in younger persons.
Adherence in older persons was associated with age, socioeconomic status, and
therapy-related factors.
DOI: 10.3389/fphar.2019.00168
PMCID: PMC6425867
PMID: 30930769
Author information:
(1)Addis Ababa University, School of Public Health, Department of Preventive
Medicine, Addis Ababa, Ethiopia.
(2)Management Sciences for Health (MSH), Addis Ababa, Ethiopia.
Abdel-Latif MM(1).
Author information:
(1)Department of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah
University, Al-Madinah Al-Munawwarah, Saudi Arabia, Egypt; Department of Clinical
Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
CONTEXT: Medication errors are the most common types of medical errors in
hospitals and leading cause of morbidity and mortality among patients.
AIMS: The aim of the present study was to assess the knowledge of healthcare
professionals about medication errors in hospitals.
SETTINGS AND DESIGN: A self-administered questionnaire was distributed to
randomly selected healthcare professionals in eight hospitals in Madinah, Saudi
Arabia.
SUBJECTS AND METHODS: An 18-item survey was designed and comprised questions on
demographic data, knowledge of medication errors, availability of reporting
systems in hospitals, attitudes toward error reporting, causes of medication
errors.
STATISTICAL ANALYSIS USED: Data were analyzed with Statistical Package for the
Social Sciences software Version 17.
RESULTS: A total of 323 of healthcare professionals completed the questionnaire
with 64.6% response rate of 138 (42.72%) physicians, 34 (10.53%) pharmacists, and
151 (46.75%) nurses. A majority of the participants had a good knowledge about
medication errors concept and their dangers on patients. Only 68.7% of them were
aware of reporting systems in hospitals. Healthcare professionals revealed that
there was no clear mechanism available for reporting of errors in most hospitals.
Prescribing (46.5%) and administration (29%) errors were the main causes of
errors. The most frequently encountered medication errors were
anti-hypertensives, antidiabetics, antibiotics, digoxin, and insulin.
CONCLUSIONS: This study revealed differences in the awareness among healthcare
professionals toward medication errors in hospitals. The poor knowledge about
medication errors emphasized the urgent necessity to adopt appropriate measures
to raise awareness about medication errors in Saudi hospitals.
DOI: 10.4103/0976-0105.183264
PMCID: PMC4910473
PMID: 27330261
Tanda G(1).
Author information:
(1)Medication Development Program, Molecular Targets and Medication Discovery
Branch, Intramural Research Program, National Institute on Drug Abuse, National
Institutes of Health, Department of Health and Human Services, 333 Cassell Drive,
Triad Bldg., NIDA suite 3301, Baltimore, MD, 21224, USA. gtanda@mail.nih.gov.
RATIONALE: The reinforcing effects of most abused drugs have been consistently
demonstrated and studied in animal models, although those of marijuana were not,
until the demonstration 15 years ago that delta-9-tetrahydrocannabinol (THC)
could serve as a reinforcer in self-administration (SA) procedures in squirrel
monkeys. Until then, those effects were inferred using indirect assessments.
OBJECTIVES: The aim of this manuscript is to review the primary preclinical
procedures used to indirectly and directly infer reinforcing effects of
cannabinoid drugs.
METHODS: Results will be reviewed from studies of cannabinoid discrimination,
intracranial self-stimulation (ICSS), conditioned place preference (CPP), as well
as change in levels of dopamine assessed in brain areas related to reinforcement,
and finally from self-administration procedures. For each procedure, an
evaluation will be made of the predictive validity in detecting the potential
abuse liability of cannabinoids based on seminal papers, with the addition of
selected reports from more recent years especially those from Dr. Goldberg's
research group.
RESULTS AND CONCLUSIONS: ICSS and CPP do not provide consistent results for the
assessment of potential for abuse of cannabinoids. However, drug discrimination
and neurochemistry procedures appear to detect potential for abuse of
cannabinoids, as well as several novel "designer cannabinoid drugs." Though after
15 years transfer of the self-administration model of marijuana abuse from
squirrel monkeys to other species remains somewhat problematic, studies with the
former species have substantially advanced the field, and several reports have
been published with consistent self-administration of cannabinoid agonists in
rodents.
DOI: 10.1007/s00213-016-4244-7
PMCID: PMC5073892
PMID: 27026633 [Indexed for MEDLINE]
Cook PF(1), Schmiege SJ, Mansberger SL, Kammer J, Fitzgerald T, Kahook MY.
Author information:
(1)University of Colorado College of Nursing, University of Colorado, Campus Box
C288-04, Aurora, CO, 80045, USA, paul.cook@ucdenver.edu.
Comment in
Ann Behav Med. 2015 Feb;49(1):5-6.
DOI: 10.1007/s12160-014-9641-8
PMCID: PMC4336606
PMID: 25248302 [Indexed for MEDLINE]
Pai ALH(1), Rausch J(2), Drake S(3), Morrison CF(3), Lee JL(4), Nelson A(5),
Tackett A(4), Berger S(5), Szulczewski L(6), Mara C(7), Davies S(8).
Author information:
(1)Patient and Family Wellness Center, Cancer and Blood Diseases Institute,
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Center for the
Promotion of Adherence and Self-Management, Division of Behavioral Medicine and
Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati,
Ohio; Department of Pediatrics, University of Cincinnati School of Medicine,
Cincinnati, Ohio. Electronic address: ahna.pai@cchmc.org.
(2)Center for Biobehavioral Health, Nationwide Children's Hospital, Cincinnati,
Ohio.
(3)Patient and Family Wellness Center, Cancer and Blood Diseases Institute,
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Center for the
Promotion of Adherence and Self-Management, Division of Behavioral Medicine and
Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati,
Ohio.
(4)Center for the Promotion of Adherence and Self-Management, Division of
Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital
Medical Center, Cincinnati, Ohio.
(5)Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and
Blood Diseases Institute, Cincinnati Children's Hospital Medical Center,
Cincinnati, Ohio.
(6)Patient and Family Wellness Center, Cancer and Blood Diseases Institute,
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Center for the
Promotion of Adherence and Self-Management, Division of Behavioral Medicine and
Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati,
Ohio; Department of Pediatrics, University of Cincinnati School of Medicine,
Cincinnati, Ohio.
(7)Department of Pediatrics, University of Cincinnati School of Medicine,
Cincinnati, Ohio.
(8)Department of Pediatrics, University of Cincinnati School of Medicine,
Cincinnati, Ohio; Division of Bone Marrow Transplantation and Immune Deficiency,
Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical
Center, Cincinnati, Ohio.
Copyright © 2017 The American Society for Blood and Marrow Transplantation.
Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.bbmt.2017.10.033
PMID: 29102720 [Indexed for MEDLINE]
Author information:
(1)Pharmaceutical Fund and Supply Agency, Addis Ababa, Ethiopia.
(2)Department of Pharmacy, College of Public Health and Medical Sciences, Jimma
University, Jimma, Ethiopia.
DOI: 10.4103/0975-7406.171696
PMCID: PMC4832902
PMID: 27134464
1106. Iran Red Crescent Med J. 2016 May 10;18(6):e35805. doi: 10.5812/ircmj.35805.
eCollection 2016 Jun.
Author information:
(1)Social Determinants of Health Research Center, Yasuj University of Medical
Sciences, Yasuj, IR Iran.
(2)Department of Community Medicine, School of Medicine, Yasuj University of
Medical Sciences, Yasuj, IR Iran.
(3)Department of Biostatistics and Epidemiology, Kermanshah University of Medical
Sciences, Kermanshah, IR Iran.
(4)Department of Health Education and Promotion, School of Health, Isfahan
University of Medical Sciences, Isfahan, IR Iran.
DOI: 10.5812/ircmj.35805
PMCID: PMC5004506
PMID: 27621938
1107. PLoS One. 2015 Apr 24;10(4):e0124247. doi: 10.1371/journal.pone.0124247.
eCollection 2015.
Poole SG(1), Bell JS(2), Jokanovic N(1), Kirkpatrick CM(2), Dooley MJ(1).
Author information:
(1)Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical
Sciences, Monash University, Melbourne, Victoria, Australia; Pharmacy Department,
Alfred Health, Melbourne, Victoria, Australia.
(2)Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical
Sciences, Monash University, Melbourne, Victoria, Australia.
DOI: 10.1371/journal.pone.0124247
PMCID: PMC4409061
PMID: 25909191 [Indexed for MEDLINE]
1108. J Hum Hypertens. 2016 Jan;30(1):73-8. doi: 10.1038/jhh.2015.26. Epub 2015 Apr
2.
Hong K(1), Muntner P(2), Kronish I(3), Shilane D(4), Chang TI(5).
Author information:
(1)Stanford University School of Medicine, Stanford, CA, USA.
(2)Departments of Medicine and Epidemiology, University of Alabama at Birmingham,
Birmingham, AL, USA.
(3)Center for Behavioral Cardiovascular Health, Department of Medicine, Columbia
University College of Physician & Surgeons, New York, NY, USA.
(4)Department of Health Research and Policy, Stanford University School of
Medicine, Stanford, CA, USA.
(5)Division of Nephrology, Department of Medicine, Stanford University School of
Medicine, Palo Alto, CA, USA.
DOI: 10.1038/jhh.2015.26
PMCID: PMC4592365
PMID: 25833706 [Indexed for MEDLINE]
Van den Houte K(1), Carbone F(1), Pannemans J(1), Corsetti M(1), Fischler B(1),
Piessevaux H(1), Tack J(1).
Author information:
(1)Department of Chronic Diseases, Metabolism and Ageing, University of Leuven,
Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven,
Belgium.
Background and aims: The symptom-based diagnostic criteria for irritable bowel
syndrome (IBS) have recently been revised in the Rome IV consensus. On the other
hand, with rising public awareness of IBS, self-diagnosis and self-management is
also increasing. We compared the prevalence and impact of Rome IV-based IBS vs
self-diagnosed IBS in the general population.
Methods: An internet panel filled out an online survey on bowel symptoms and
their impact on health care utilization and daily activities.
Results: A representative internet panel of 1012 individuals completed the online
survey. Bowel symptoms were present in 68.6% of the population. Of these, 21%
consulted a physician for these symptoms in the last year and 42% earlier. Rome
IV IBS criteria were fulfilled by 5.5%, and these were younger and more likely to
be female. In this subset, 37% had consulted a physician for IBS symptoms in the
preceding year and 29% had done so earlier. A colonoscopy had been performed in
22%. Based on a brief description, 17.6% of the population self-identified as
suffering from IBS (p < 0.001 compared to Rome IV IBS prevalence), and these were
more likely to be female. Concordance with the Rome IV criteria was only 25%, but
except for a lower reporting of pain, the symptom pattern, severity, impact on
daily life, inability to work and health care utilization were similar to the
Rome IV group. A total of 134 days of absence from work were attributed to bowel
symptoms in those self-reporting with IBS.
Conclusion: In the general population, bowel symptoms are highly prevalent, and
the self-reported "IBS" is three times more prevalent than according to Rome IV
criteria. Self-reported IBS is associated with a similar impact on health care
utilization and quality of life but a higher impact on absence from work.
DOI: 10.1177/2050640618821804
PMCID: PMC6498809
PMID: 31080615
Maddison R(1), Stewart R(2), Doughty R(3), Scott T(4), Kerr A(5), Benatar J(2),
Whittaker R(6), Rawstorn JC(7), Rolleston A(8), Jiang Y(6), Estabrooks P(9),
Sullivan RK(10), Bartley H(6), Pfaeffli Dale L(11).
Author information:
(1)Institute for Physical Activity and Nutrition, Deakin University, Geelong,
VIC, Australia. ralph.maddison@deakin.edu.au.
(2)Department of Cardiology, Auckland District Health Board, Auckland, New
Zealand.
(3)Heart Health Research Group, Department of Medicine, University of Auckland,
Auckland, New Zealand.
(4)Department of Cardiology, Waitemata District Health Board, Auckland, New
Zealand.
(5)Epidemiology and Biostatistics, University of Auckland, Auckland, New Zealand.
(6)National Institute for Health Innovation, School of Population Health,
University of Auckland, Auckland, New Zealand.
(7)Institute for Physical Activity and Nutrition, Deakin University, Geelong,
VIC, Australia.
(8)The Centre for Health, Tauranga, New Zealand.
(9)Department of Health Promotion, Social and Behavioral Health, University of
Nebraska Medical Centre, Omaha, NE, USA.
(10)Department of Exercise Sciences, Faculty of Science, University of Auckland,
Auckland, New Zealand.
(11)School of Kinesiology, University of British Columbia, Vancouver, BC, Canada.
DOI: 10.1186/s13063-018-2468-z
PMCID: PMC5785898
PMID: 29370829 [Indexed for MEDLINE]
Newman-Casey PA(1), Robin AL(2), Blachley T(3), Farris K(4), Heisler M(5),
Resnicow K(6), Lee PP(3).
Author information:
(1)Department of Ophthalmology & Visual Sciences, University of Michigan Medical
School, Ann Arbor, Michigan. Electronic address: panewman@med.umich.edu.
(2)Department of Ophthalmology & Visual Sciences, University of Michigan Medical
School, Ann Arbor, Michigan; Department of Ophthalmology & International Health,
Johns Hopkins University, Baltimore, Maryland.
(3)Department of Ophthalmology & Visual Sciences, University of Michigan Medical
School, Ann Arbor, Michigan.
(4)School of Pharmacy, University of Michigan, Ann Arbor, Michigan.
(5)School of Public Health, University of Michigan, Ann Arbor, Michigan;
Department of Internal Medicine, University of Michigan Medical School, Ann
Arbor, Michigan.
(6)School of Public Health, University of Michigan, Ann Arbor, Michigan.
Comment in
Ophthalmology. 2015 Jul;122(7):1280-2.
DOI: 10.1016/j.ophtha.2015.03.026
PMCID: PMC4485580
PMID: 25912144 [Indexed for MEDLINE]
Berry DL(1), Blonquist TM(2), Hong F(3), Halpenny B(4), Partridge AH(5).
Author information:
(1)Phyllis F Cantor Center, Dana-Farber Cancer Institute, Boston, MA, USA ;
Medical Oncology, Department of Medicine, Dana-Farber Cancer Institute, Boston,
MA, USA ; Department of Medicine, Harvard Medical School, Boston, MA, USA.
(2)Department of Biostatistics and Computational Biology, Dana-Farber Cancer
Institute, Boston, MA, USA.
(3)Department of Biostatistics and Computational Biology, Dana-Farber Cancer
Institute, Boston, MA, USA ; Department of Biostatistics, Harvard School of
Public Health, Boston, MA, USA.
(4)Phyllis F Cantor Center, Dana-Farber Cancer Institute, Boston, MA, USA.
(5)Medical Oncology, Department of Medicine, Dana-Farber Cancer Institute,
Boston, MA, USA ; Department of Medicine, Harvard Medical School, Boston, MA,
USA.
DOI: 10.2147/PPA.S91534
PMCID: PMC4639537
PMID: 26604712
Wilcox L(1), Woollen J(2), Prey J(2), Restaino S(3), Bakken S(2), Feiner S(4),
Sackeim A(3), Vawdrey DK(5).
Author information:
(1)School of Interactive Computing, Georgia Institute of Technology, Atlanta, GA,
USA Department of Computer Science, Columbia University, New York, NY, USA
wilcox@cc.gatech.edu.
(2)Department of Biomedical Informatics, Columbia University, New York, NY, USA.
(3)College of Physicians and Surgeons, Columbia University Medical Center, New
York, NY, USA.
(4)Department of Computer Science, Columbia University, New York, NY, USA.
(5)Department of Biomedical Informatics, Columbia University, New York, NY, USA
New York-Presbyterian Hospital, New York, NY, USA.
© The Author 2016. Published by Oxford University Press on behalf of the American
Medical Informatics Association. All rights reserved. For Permissions, please
email: journals.permissions@oup.com.
DOI: 10.1093/jamia/ocv160
PMCID: PMC5009934
PMID: 26744489 [Indexed for MEDLINE]
Reading SR(1), Black MH(1), Singer DE(2), Go AS(3)(4), Fang MC(5), Udaltsova
N(3), Harrison TN(1), Wei RX(1), Liu IA(1), Reynolds K(6); ATRIA-CVRN
Investigators.
Author information:
(1)Department of Research and Evaluation, Kaiser Permanente Southern California,
100 S. Los Robles Ave., 2nd floor, Pasadena, CA, 91101, USA.
(2)Department of General Internal Medicine, Massachusetts General Hospital,
Boston, MA, USA.
(3)Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
(4)Departments of Epidemiology, Biostatistics and Medicine, University of
California San Francisco, San Francisco, CA, USA.
(5)Division of Hospital Medicine, University of California San Francisco, San
Francisco, CA, USA.
(6)Department of Research and Evaluation, Kaiser Permanente Southern California,
100 S. Los Robles Ave., 2nd floor, Pasadena, CA, 91101, USA.
kristi.reynolds@kp.org.
DOI: 10.1186/s12872-019-1019-1
PMCID: PMC6371431
PMID: 30744554
Garvie PA(1), Brummel SS, Allison SM, Malee KM, Mellins CA, Wilkins ML, Harris
LL, Patton ED, Chernoff MC, Rutstein RM, Paul ME, Nichols SL; Pediatric HIV/AIDS
Cohort Study.
Author information:
(1)From the *Research Department, Children's Diagnostic & Treatment Center, Fort
Lauderdale, Florida; †Center for Biostatistics in AIDS Research, Harvard T.H.
Chan School of Public Health, Boston, Massachusetts; ‡Division of AIDS Research,
National Institute of Mental Health, Bethesda, Maryland; §Department of
Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of
Medicine, Chicago, Illinois; ¶Department of Psychiatry and Sociomedical Sciences,
HIV Center for Clinical and Behavioral Studies, New York State Psychiatric
Institute and Columbia University, New York, New York; ‖Department of Infectious
Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee; **Department
of Pediatrics, Baylor College of Medicine, Houston, Texas; ††Private Practice,
Fort Lauderdale, Florida; ‡‡Division of General Pediatrics, Children's Hospital
of Philadelphia, Philadelphia, Pennsylvania; §§Department of Pediatrics, Texas
Children's Hospital, Houston, Texas; and ¶¶Department of Neurosciences,
University of California, La Jolla, San Diego, California.
DOI: 10.1097/INF.0000000000001573
PMCID: PMC5512435
PMID: 28709161 [Indexed for MEDLINE]
Author information:
(1)1 Department of Psychology, Hunter College of the City University of New York
(CUNY) , New York, New York.
(2)2 Health Psychology and Clinical Science Doctoral Program, Graduate Center,
City University of New York (CUNY) , New York, New York.
(3)3 Center for HIV/AIDS Educational Studies and Training (CHEST) , New York, New
York.
(4)4 Department of Psychology, Muhlenberg College , Allentown, Pennsylvania.
Although rates of crystal methamphetamine use in the United States have fallen
from their peak in the mid-2000s, use remains a major public health concern,
which disproportionately affects gay and bisexual men (GBM). It poses a
particular challenge for HIV-positive men, for whom it has been linked to
medication adherence problems as well as compromised immune function. Although
the information, motivation, and behavioral skills (IMB) model has been widely
used to conceptualize health behavior, little is known about GBM's initial levels
of information, motivation, and behavioral self-efficacy to improve HIV
medication adherence and to reduce crystal methamphetamine use at the outset of
treatment. The present study identified profiles of IMB factors related to HIV
medication adherence and crystal methamphetamine use in a sample of 210
HIV-positive GBM who consented to participate in an intervention study. Results
indicated three distinct patterns of IMB factors. The largest group was ready to
change both adherence and methamphetamine use (n = 104). This group also had
depression scores that were significantly lower than other groups. A second group
appeared ready to change medication adherence, but was ambivalent about changing
methamphetamine use (n = 60). This group reported significantly more symptoms of
methamphetamine dependence than the other groups. A third group was characterized
by global IMB barriers to change (n = 46). Results are discussed in the context
of tailoring psychoeducation, motivational interviewing, and cognitive behavioral
interventions to match these preintervention patterns of IMB factors.
DOI: 10.1089/apc.2016.0196
PMCID: PMC5312573
PMID: 28092450 [Indexed for MEDLINE]
Raymond JF(1)(2), Bucek A(1)(2), Dolezal C(1)(2), Warne P(1)(2), Benson S(1)(2),
Abrams EJ(3), Elkington KS(1)(2), Kalichman S(4), Kalichman M(4), Mellins
CA(1)(2).
Author information:
(1)HIV Center for Clinical and Behavioral Studies, New York State Psychiatric
Institute.
(2)Columbia University.
(3)ICAP, Columbia University Mailman School of Public Health.
(4)University of Connecticut.
© The Author 2017. Published by Oxford University Press on behalf of the Society
of Pediatric Psychology. All rights reserved. For permissions, please e-mail:
journals.permissions@oup.com
DOI: 10.1093/jpepsy/jsx064
PMCID: PMC5896628
PMID: 28369465 [Indexed for MEDLINE]
Gordon E(1), Rush AJ(2), Palmer DM(3), Braund TA(4), Rekshan W(1).
Author information:
(1)Brain Resource, San Francisco, CA, USA.
(2)Duke-NUS, Singapore.
(3)Brain Resource, Sydney, NSW, Australia ; Brain Dynamics Center, Sydney Medical
School - Westmead and Westmead Millennium Institute, The University of Sydney,
Sydney, NSW, Australia.
(4)Brain Resource, Sydney, NSW, Australia.
DOI: 10.2147/NDT.S75975
PMCID: PMC4348126
PMID: 25750532
Fatalism, faith and fear: A case study of self-care practice among adults with
Type 2 diabetes in urban Malaysia.
Author information:
(1)Kulliyyah of Nursing, International Islamic University Malaysia, Kuantan
Pahang, Malaysia.
(2)School of Healthcare, University of Leeds, Leeds, UK.
(3)Division of Nursing, Midwifery and Social Work, School of Health Sciences,
University of Manchester, Manchester, UK.
AIMS AND OBJECTIVES: To explore self-care and self-care support in patients with
Type 2 diabetes in urban Malaysia.
BACKGROUND: The prevalence of Type 2 diabetes in Malaysia and associated
long-term and life-changing complications is increasing. With effective self-care
and self-care support, severe complications of the condition can be avoided or
reduced. Prior to this study, no evidence existed about Malaysian patients'
management of the condition or support for self-care from the healthcare system.
DESIGN: A single embedded qualitative case study.
METHODS: Semistructured interviews with 18 patients with Type 2 diabetes aged
28-69 years, healthcare professionals (n = 19), observations (n = 13) of clinic
appointments from two urban settings in Malaysia and a documentary analysis.
Recordings were transcribed verbatim, field notes were made during observations
and the data analysed and synthesised within and across case using Framework
analysis.
FINDINGS: Three main themes explained self-care and self-care support in
Malaysia: fatalism, faith and fear. Patients were fatalistic about developing
diabetes-they perceived it as inevitable because it is so common in Malaysia.
However, faith in God, coupled with fear of the consequences of diabetes,
motivated them to engage in self-care practices. The fear was largely induced by
diabetes healthcare professionals working in overcrowded clinics, and stretched
thinly across the service, who used a direct and uncompromising approach to
instil the importance of self-care to avoid severe long-term complications.
CONCLUSION: This study provided important insight on how people in Malaysia
developed diabetes, their responses to the disease and the approach of healthcare
professionals in supporting them to engage with self-care.
RELEVANCE TO CLINICAL PRACTICE: Any future development of self-care programmes in
Malaysia needs to recognise the factors that motivate patients to self-care and
include components that build self-efficacy.
DOI: 10.1111/jocn.14559
PMID: 29893043 [Indexed for MEDLINE]
1120. Gerontol Geriatr Med. 2019 Jun 27;5:2333721419855662. doi:
10.1177/2333721419855662. eCollection 2019 Jan-Dec.
Pagan-Ortiz ME(1), Goulet P(2), Kogelman L(3), Levkoff SE(1)(4), Weitzman PF(1).
Author information:
(1)Environment and Health Group, Cambridge, MA, USA.
(2)Boston Medical Center, MA, USA.
(3)Tufts Medical Center, Boston, MA, USA.
(4)University of South Carolina, Columbia, USA.
Antiretroviral therapy (ART) is the primary treatment for HIV, and adherence to
it is crucial to addressing health disparities. Approximately half of individuals
in the United States living with HIV are African Americans, and those over 45
years of age are more likely to die early from HIV/AIDS than their White
counterparts. This mixed-method pilot study evaluated the feasibility of a
text-based mobile phone intervention designed to improve ART adherence among
older African Americans with HIV. Feasibility was assessed via implementation,
participant adherence, acceptability, and satisfaction, as well as short-term
impact on medication adherence, adherence-related self-efficacy, and positive
affect. The intervention utilized pill reminder, motivational, and health
educational texts. Participants (N = 21) ranged in age from 50 to 68 years.
Outcomes were evaluated via quantitative results from self-report measures and
qualitative data from four focus groups. Attrition to the study was 100%. After 8
weeks, participants reported statistically significant improvements in medication
adherence, but not in self-efficacy or affect scores. Qualitative findings
highlight the psychologically supportive potential of the intervention,
challenges to adherence, as well as suggestions for improvement. The study
demonstrates that a text messaging intervention may be feasible for older African
Americans with HIV, and helpful in supporting ART adherence.
DOI: 10.1177/2333721419855662
PMCID: PMC6598320
PMID: 31276016
Sajatovic M(1)(2)(3), Levin JB(1)(2), Sams J(1)(2), Cassidy KA(1), Akagi K(1),
Aebi ME(2), Ramirez LF(1), Safren SA(4), Tatsuoka C(2)(3).
Author information:
(1)Department of Psychiatry, Case Western Reserve University School of Medicine,
Cleveland, OH, USA.
(2)University Hospitals Case Medical Center, Neurological and Behavioral Outcomes
Center, Cleveland, OH, USA.
(3)Department of Neurology, Case Western Reserve University School of Medicine,
Cleveland, OH, USA.
(4)Department of Psychiatry, Harvard Medical School/Massachusetts General
Hospital, Boston, MA, USA.
OBJECTIVES: This analysis of screening and baseline data from an ongoing trial
examined self-report versus automated adherence monitoring and assessed the
relationship between bipolar disorder (BD) symptoms and adherence in 104 poorly
adherent individuals.
METHODS: Adherence was measured with the Tablets Routine Questionnaire (TRQ) and
the Medication Event Monitoring System (MEMS). Symptoms were measured with the
Montgomery-Åsberg Depression Rating Scale (MADRS), the Young Mania Rating Scale
(YMRS), and the Brief Psychiatric Rating Scale (BPRS).
RESULTS: The mean age of the sample was 46.3 years [standard deviation (SD) =
9.41 years], with 72% (n = 75) women and 71% (n = 74) African American subjects.
Adherence improved from screening to baseline, with a mean missed drug proportion
measured by TRQ of 61.43% (SD = 26.48%) versus a baseline mean of 46.61% (SD =
30.55%). The mean proportion of missed medication using MEMS at baseline was
66.43% (SD = 30.40%). The correlation between TRQ and MEMS was 0.47. The
correlation between a single index drug and all BD medications was 0.95. Symptoms
were generally positively correlated with TRQ (worse adherence = more severe
symptoms), but in most instances was only at a trend level (p > 0.05), with the
exception of the correlations between baseline TRQ and MADRS and BPRS, which were
positive (r = 0.20 and r = 0.21, respectively) and significant (p ≤ 0.05).
CONCLUSIONS: In patients with BD, monitoring increased adherence by 15%. MEMS
identified 20% more non-adherence than self-report. Using a standard procedure to
identify a single index drug for adherence monitoring may be one way to assess
global adherence in patients with BD receiving polypharmacy treatment. Greater BD
symptom severity may be a clinical indicator to assess for adherence problems.
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
DOI: 10.1111/bdi.12326
PMCID: PMC4632982
PMID: 26529124 [Indexed for MEDLINE]
van der Laan DM(1), Langendoen-Gort M(2), Nijpels G(2), Boons CCLM(3), Elders
PJM(2), Hugtenburg JG(3).
Author information:
(1)Department of Clinical Pharmacology and Pharmacy, Amsterdam Public Health
Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan
1117, Amsterdam, The Netherlands. d.vanderlaan1@vumc.nl.
(2)Department of General Practice and Elderly Care Medicine, Amsterdam Public
Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, De
Boelelaan 1117, Amsterdam, The Netherlands.
(3)Department of Clinical Pharmacology and Pharmacy, Amsterdam Public Health
Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan
1117, Amsterdam, The Netherlands.
DOI: 10.1007/s11096-019-00845-z
PMCID: PMC6677874
PMID: 31093942
Ruan Y(1), Xiao X(2), Chen J(2), Li X(2), Williams AB(3), Wang H(2).
Author information:
(1)Nursing Department, Second Xiangya Hospital.
(2)Xiangya School of Nursing, Central South University, Changsha, Hunan, People's
Republic of China.
(3)School of Nursing, Yale University, West Haven, CT, USA.
AIM: The aim of this study was to examine the acceptability and efficacy of
interactive short message service (SMS) in improving medication adherence in
antiretroviral treatment (ART)-naïve individuals living with HIV/AIDS in
Hengyang, Hunan, China.
BACKGROUND: SMS via mobile phone has emerged as a potential tool for improving
ART adherence. However, most studies used SMS only as a medication reminder, with
few studies exploring the effect of comprehensive, interactive SMS.
PATIENTS AND METHODS: In a randomized controlled trial, 100 HIV-positive patients
on ART for <3 months were randomized into control or intervention arm.
Participants in the control group received routine standard instruction for ART
medication in the HIV clinics, while the intervention group received 6 months of
an SMS intervention in addition to the standard care. A total of 124 text
messages within 6 modules were edited, preinstalled, and sent to participants
according to personalized schedules. Knowledge (of HIV and HIV medications),
self-reported antiretroviral adherence (Visual Analog Scale [VAS] and Community
Programs for Clinical Research on AIDS [CPCRA] Antiretroviral Medication
Self-Report), and CD4 count were assessed at baseline and immediate
post-intervention. Intervention participants were interviewed after completion of
the study about their satisfaction with and acceptability of the SMS
intervention.
RESULTS: Baseline assessments were comparable between arms. Repeated-measures
analysis showed that both HIV-related and ART medication knowledge of the
intervention group showed better improvement over time than those of the control
group after the intervention (P<0.0001). For the adherence measures, compared
with the control group, participants in the intervention group had significantly
higher VAS mean score (Z=2.735, P=0.006) and lower suboptimal adherence rate
(Z=2.208, P=0.027) at the end of the study. The intervention had no effect on CD4
cell count. Almost all (96%) intervention participants reported satisfaction or
high satisfaction with the SMS intervention, with 74% desiring to continue to
receive the SMS intervention. The preferred frequency of messages was 1-2
messages per week.
CONCLUSION: An interactive SMS intervention with comprehensive content shows
promising efficacy in promoting medication adherence in ART-naïve individuals.
Future work might further refine its ability to optimally tailor the intervention
for individual preferences.
DOI: 10.2147/PPA.S120003
PMCID: PMC5312688
PMID: 28228652
Author information:
(1)Aston University, Aston Triangle, Birmingham, B4 7ET, UK. medha288@gmail.com.
(2)Aston University, Aston Triangle, Birmingham, B4 7ET, UK.
(3)Sussex Partnership NHS Foundation Trust, Brighton, West Sussex, BN13 3EP, UK.
(4)University of Huddersfield, Huddersfield, West Yorkshire, HD1 3DH, UK.
DOI: 10.1007/s11096-015-0236-7
PMCID: PMC4828472
PMID: 26739128 [Indexed for MEDLINE]
Author information:
(1)General Internal Medicine and Geriatrics, Northwestern University, Chicago,
Illinois, USA r-oconor@northwestern.edu.
(2)School of Public Health, University of Illinois at Chicago, Chicago, Illinois,
USA.
(3)Department of Preventive Medicine, Northwestern University, Chicago, Illinois,
USA.
(4)College of Nursing, University of Illinois at Chicago, Chicago, Illinois, USA.
(5)Denver Health and Hospital Authority, Denver, Colorado, USA.
(6)Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
(7)Department of General Internal Medicine, Northwestern University, Chicago,
Illinois, USA.
DOI: 10.1136/bmjopen-2018-027430
PMID: 31462464
Thom DH(1), Willard-Grace R(2), Hessler D(2), DeVore D(2), Prado C(2),
Bodenheimer T(2), Chen E(2).
Author information:
(1)From the Department of Family and Community Medicine, University of
California, San Francisco, School of Medicine; San Francisco (DHT, RW-G, DH, DD,
CP, TB, EC); and the Silver Avenue Health Center, San Francisco, CA (EC).
dthom@fcm.ucsdf.edu.
(2)From the Department of Family and Community Medicine, University of
California, San Francisco, School of Medicine; San Francisco (DHT, RW-G, DH, DD,
CP, TB, EC); and the Silver Avenue Health Center, San Francisco, CA (EC).
DOI: 10.3122/jabfm.2015.01.140123
PMID: 25567821 [Indexed for MEDLINE]
Author information:
(1)Health Equity and Rural Outreach Innovation Center (HEROIC), Charleston VA
HSR&D COIN, Ralph H. Johnson VAMC, Charleston, SC, USA; Center for Health
Disparities Research, Medical University of South Carolina, Charleston, SC, USA.
(2)Center for Surgery and Public Health, Brigham and Women's Hospital, Boston,
MA, USA.
(3)Health Equity and Rural Outreach Innovation Center (HEROIC), Charleston VA
HSR&D COIN, Ralph H. Johnson VAMC, Charleston, SC, USA; Center for Health
Disparities Research, Medical University of South Carolina, Charleston, SC, USA;
Division of General Internal Medicine and Geriatrics, Department of Medicine,
Medical University of South Carolina, Charleston, SC, USA. Electronic address:
egedel@musc.edu.
DOI: 10.1016/j.diabres.2015.09.007
PMCID: PMC4681588
PMID: 26411692 [Indexed for MEDLINE]
1128. Shanghai Arch Psychiatry. 2014 Dec;26(6):347-56. doi:
10.11919/j.issn.1002-0829.214101.
Hocaoglu C(1), Celik FH(1), Kandemir G(1), Guveli H(2), Bahceci B(1).
Author information:
(1)Department of Psychiatry,Recep Tayyip Erdogan University, Rize, Turkey.
(2)Istanbul University Oncology Enstitude, Department of Psychiatry, Istanbul,
Turkey.
Publisher:
性功能障碍是影响患者对抗精神病药物服药依从性的因素之一,但尚不清楚这个问题的严重程度。比较服用抗精
神病药物且临床症状稳定的精神分裂症患者和健康对照者自我报告的性功
能状况。评估工具采用土耳其语版的 5 个条目的亚利桑那性体验量表(Arizona Sexual Experience Scale
,ASEX)。该量表的效度已在土耳其得到验证。量表评估性欲、性唤起、阴道润滑/阴茎勃起、达到高潮的能力
以及对高潮的满意度等 5 个方面的性功能。采用阳性症状量表、阴性
症状量表和 ASEX 分别对 101 例临床症状稳定的门诊精神分裂症患者(女性 38 例、男性 63 例)进行评估。对 89
例无精神疾病史的对照者(女性 41 名、男性 48 名)也进行了
ASEX 量表评估。如果 ASEX 总分(范围 5-30)>18,或者任一条目得分(范围 1-6)≥5,或者至少有 3 个条目
得分都大于 4,则被视为存在性功能障碍。自我报告有性
功能障碍的男性精神分裂症患者多于健康对照者(46%对 8%)。虽然女性患者性功能障碍的患病率显著高于男
性患者(68%对 46%),但是对照组中健康女性的性功能障碍患病
率也非常高(68%),因而女性患者的性功能障碍不能归咎于她们的疾病或是正在服用的药物。患者组中,阳性
症状和阴性症状的严重程度与性功能障碍无相关性,服用第一代抗精神
病药的患者与服用第二代抗精神病药的患者之间的性功能障碍严重程度无明显差异。在土耳其,不同性别的精神
分裂症患者性功能状况的研究结果不同,这凸显了在评估精神障碍和药物
对性功能的影响时制定特定区域、特定性别的性行为社会规范的重要性。今后需要采用前瞻性研究来区分文化规
范、精神疾病以及使用的抗精神病药物在精神分裂症患者性功能障碍的病
因和病程中的相对作用。
DOI: 10.11919/j.issn.1002-0829.214101
PMCID: PMC4311108
PMID: 25642109
Tailakh AK(1), Evangelista LS(2), Morisky DE(3), Mentes JC(3), Pike NA(3),
Phillips LR(3).
Author information:
(1)California State University, Los Angeles, CA, USA
ayman.tailakh@calstatela.edu.
(2)University of California, Irvine, CA, USA.
(3)University of California, Los Angeles, CA, USA.
PURPOSE: The aim of this study was to examine the relationship between
acculturation, medication adherence, lifestyle behaviors (e.g., physical
activity, nutrition, weight control), and blood pressure control among
hypertensive Arab Americans.
DESIGN: The study utilized a cross-sectional descriptive design. A convenience
sample of 126 participants completed questionnaires and had measures of blood
pressure, weight, and height. Forty-six participants were hypertensive and were
included in the analysis.
RESULTS: Only 29.2% of participants reported high medication adherence. High
medication adherence was associated with lower diastolic blood pressure, eating a
healthy diet, and following lifestyle modifications. Acculturation was
significantly associated with physical activity and body mass index.
CONCLUSION: Our study found that acculturated participants were more adherent to
medications and physical activity and had better blood pressure control. Further
studies are needed to explore how acculturation improves adherence and what
factors contribute to better adherence in order to design culturally sensitive
interventions.
DOI: 10.1177/1043659614526456
PMCID: PMC4446252
PMID: 24848347 [Indexed for MEDLINE]
1130. ESC Heart Fail. 2019 Feb;6(1):164-173. doi: 10.1002/ehf2.12380. Epub 2018 Nov
27.
Author information:
(1)Department of Cardiology, West China Hospital, Sichuan University, No. 37 Guo
Xue Xiang, Chengdu, China.
(2)Department of Cardiovascular Surgery, West China Hospital, Sichuan University,
Chengdu, China.
© 2018 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on
behalf of the European Society of Cardiology.
DOI: 10.1002/ehf2.12380
PMCID: PMC6352960
PMID: 30478888 [Indexed for MEDLINE]
Nachar VR(1)(2), Farris K(2)(3), Beekman K(4), Griggs J(1)(3), Hough S(1)(3),
Mackler E(3).
Author information:
(1)University of Michigan, Ann Arbor, MI.
(2)University of Michigan College of Pharmacy, Ann Arbor, MI.
(3)Michigan Oncology Quality Consortium, Ann Arbor, MI.
(4)IHA Hematology Oncology Consultants, Ypsilanti, MI.
DOI: 10.1200/CCI.18.00128
PMID: 31100014
1132. Afr J Prim Health Care Fam Med. 2016 Jul 28;8(1):e1-5. doi:
10.4102/phcfm.v8i1.900.
Author information:
(1)Department of Family Medicine & Primary Health Care, University of Limpopo.
rhinorth@mweb.co.za.
DOI: 10.4102/phcfm.v8i1.900
PMCID: PMC4992187
PMID: 27543285 [Indexed for MEDLINE]
Author information:
(1)1 Department of Psychological Medicine, University of Auckland , New Zealand .
Erratum in
AIDS Patient Care STDS. 2015 Jan;29(1):52.
DOI: 10.1089/apc.2014.0156
PMCID: PMC4216527
PMID: 25290556 [Indexed for MEDLINE]
1134. Patient Prefer Adherence. 2015 Oct 14;9:1431-41. doi: 10.2147/PPA.S88357.
eCollection 2015.
Längst G(1), Seidling HM(2), Stützle M(2), Ose D(1), Baudendistel I(1), Szecsenyi
J(1), Wensing M(3), Mahler C(1).
Author information:
(1)Department of General Practice and Health Services Research, University
Hospital of Heidelberg, Heidelberg, Germany.
(2)Cooperation Unit Clinical Pharmacy, University of Heidelberg, Heidelberg,
Germany ; Department of Clinical Pharmacology and Pharmacoepidemiology,
University of Heidelberg, Heidelberg, Germany.
(3)Department of General Practice and Health Services Research, University
Hospital of Heidelberg, Heidelberg, Germany ; Radboud University Nijmegen Medical
Centre, Scientific Institute for Quality of Healthcare, Nijmegen, the
Netherlands.
PURPOSE: This qualitative study in patients with type 2 diabetes and health care
professionals (HCPs) aimed to investigate which factors they perceive to enhance
or impede medication information provision in primary care. Similarities and
differences in perspectives were explored.
METHODS: Eight semistructured focus groups were conducted, four with type 2
diabetes patients (n=25) and four with both general practitioners (n=13) and
health care assistants (n=10). Sessions were audio and video recorded,
transcribed verbatim, and subjected to computer-aided qualitative content
analysis.
RESULTS: Diabetes patients and HCPs broadly highlighted similar factors as
enablers for satisfactory medication information delivery. Perceptions
substantially differed regarding impeding factors. Both patients and HCPs
perceived it to be essential to deliver tailored information, to have a trustful
and continuous patient-provider relationship, to regularly reconcile medications,
and to provide tools for medication management. However, substantial differences
in perceptions related to impeding factors included the causes of inadequate
information, the detail required for risk-related information, and barriers to
medication reconciliation. Medication self-management was a prevalent topic among
patients, whereas HCPs' focus was on fulfilling therapy and medication management
responsibilities.
CONCLUSION: The findings suggest a noteworthy gap in perceptions between
information provision and patients' needs regarding medication-related
communication. Medication safety and adherence may be improved if HCPs
collaborate more closely with diabetes patients in managing their medication, in
particular by incorporating the patients' perspective. Health care systems need
to be structured in a way that supports this process.
DOI: 10.2147/PPA.S88357
PMCID: PMC4612137
PMID: 26508840
Author information:
(1)Pharmacy Practice Department, University of the Pacific, Stockton, CA, USA.
(2)Thomas J Long School of Pharmacy and Health Sciences, University of the
Pacific, Stockton, CA, USA.
DOI: 10.2147/PPA.S64825
PMCID: PMC4172241
PMID: 25258521
1136. J Phys Ther Sci. 2015 Nov;27(11):3493-7. doi: 10.1589/jpts.27.3493. Epub 2015
Nov
30.
Author information:
(1)College of Public Health Sciences, Chulalongkorn University, Thailand ; School
of Health Science, Mae Fah Luang University, Thailand.
(2)College of Public Health Sciences, Chulalongkorn University, Thailand.
(3)Research Center in Back, Neck, and Other Joint Pain, and Human Performance,
Khon Kaen University, Thailand.
(4)Lat Lum Kaew Hospital, Thailand.
[Purpose] The aim of this study was to examine the effects of traditional Thai
self-massage using a Wilai massage stick(TM) versus ibuprofen on reducing upper
back pain associated with myofascial trigger points. [Subjects and Methods] Sixty
patients who were diagnosed as having upper back pain associated with myofascial
trigger points were randomly allocated to either a massage group using a Wilai
massage stick(TM) or a medication group taking ibuprofen for 5 days. Both groups
were advised to perform the same daily stretching exercise program. Pain
intensity, pressure pain threshold, tissue hardness, and cervical range of motion
were assessed at baseline, immediately after the first treatment session, and on
the fifth day after the last treatment session. [Results] The massage group had
significant improvement in all parameters at all assessment time points. Similar
changes were observed in the medication group except for the pressure pain
threshold and tissue hardness. The adjusted post-test mean values for each
assessment time point were significantly better in the massage group than in the
medication group. [Conclusion] Tradition Thai self-massage using a Wilai massage
stick(TM) provides better results than taking ibuprofen for patients who have
upper back pain associated with myofascial trigger points. It could be an
alternative treatment for this patient population.
DOI: 10.1589/jpts.27.3493
PMCID: PMC4681931
PMID: 26696724
Author information:
(1)National Institute of Cardiovascular Disease, Karachi, Pakistan.
Author information:
(1)Vanderbilt School of Nursing, Vanderbilt University, Nashville, TN, USA; The
Center for Research and Innovation in Systems Safety (CRISS), Vanderbilt
University Medical Center, Nashville, TN, USA.
(2)School of Information Studies, Syracuse University, Syracuse, NY, USA.
(3)Department of BioHealth Informatics, Indiana University School of Informatics
and Computing, Indianapolis, IN, USA.
OBJECTIVE: To use a human factors perspective to examine how older adult patients
with heart failure use cognitive artifacts for medication management.
METHODS: We performed a secondary analysis of data collected from 30 patients and
14 informal caregivers enrolled in a larger study of heart failure self-care.
Data included photographs, observation notes, interviews, video recordings,
medical record data, and surveys. These data were analyzed using an iterative
content analysis.
RESULTS: Findings revealed that medication management was complex, inseparable
from other patient activities, distributed across people, time, and place, and
complicated by knowledge gaps. We identified fifteen types of cognitive artifacts
including medical devices, pillboxes, medication lists, and electronic personal
health records used for: 1) measurement/evaluation; 2) tracking/communication; 3)
organization/administration; and 4) information/sensemaking. These artifacts were
characterized by fit and misfit with the patient's sociotechnical system and
demonstrated both advantages and disadvantages. We found that patients often
modified or "finished the design" of existing artifacts and relied on
"assemblages" of artifacts, routines, and actors to accomplish their self-care
goals.
CONCLUSIONS: Cognitive artifacts are useful but sometimes are poorly designed or
are not used optimally. If appropriately designed for usability and acceptance,
paper-based and computer-based information technologies can improve medication
management for individuals living with chronic illness. These technologies can be
designed for use by patients, caregivers, and clinicians; should support
collaboration and communication between these individuals; can be coupled with
home-based and wearable sensor technology; and must fit their users' needs,
limitations, abilities, tasks, routines, and contexts of use.
DOI: 10.1016/j.hlpt.2015.08.009
PMCID: PMC4741110
PMID: 26855882
1139. Patient Relat Outcome Meas. 2017 Nov 9;8:143-156. doi: 10.2147/PROM.S140851.
eCollection 2017.
Validating the Patient Experience with Treatment and Self-Management (PETS), a
patient-reported measure of treatment burden, in people with diabetes.
Rogers EA(1)(2), Yost KJ(3), Rosedahl JK(3), Linzer M(4), Boehm DH(5), Thakur
A(5), Poplau S(5), Anderson RT(6), Eton DT(3).
Author information:
(1)Department of Medicine, University of Minnesota Medical School, Minneapolis,
MN, USA.
(2)Department of Pediatrics, University of Minnesota Medical School, Minneapolis,
MN, USA.
(3)Department of Health Services Research, Mayo Clinic, Rochester, MN, USA.
(4)Department of Medicine, Hennepin County Medical Center, Minneapolis, MN, USA.
(5)Minneapolis Medical Research Foundation, Minneapolis, MN, USA.
(6)University of Virginia School of Medicine, Charlottesville, VA, USA.
DOI: 10.2147/PROM.S140851
PMCID: PMC5687778
PMID: 29184456
1140. Can J Hosp Pharm. 2016 Jul-Aug;69(4):286-93. Epub 2016 Aug 31.
Author information:
(1), PharmD, is with the Children's Hospital of Eastern Ontario, Ottawa, Ontario.
(2), PhD, is with the Children's Hospital of Eastern Ontario, Ottawa, Ontario.
(3), RN, is with the Institute for Safe Medication Practices Canada (ISMP
Canada), Toronto, Ontario.
(4), BScPhm, MHSc, is with the Institute for Safe Medication Practices Canada
(ISMP Canada), Toronto, Ontario.
(5), BSc, is with the Children's Hospital of Eastern Ontario, Ottawa, Ontario.
BACKGROUND: Inherent risks are associated with the preparation and administration
of medications. As such, a key aspect of medication safety is to ensure safe
medication management practices.
OBJECTIVE: To identify key medication safety issues and high-alert drug classes
that might benefit from implementation of pictograms, for use by health care
providers, to enhance medication administration safety. This study was the first
step in the development of such pictograms.
METHODS: Self-identified medication management experts participated in a modified
Delphi process to achieve consensus on situations where safety pictograms are
required for labelling to optimize safe medication management. The study was
divided into 3 phases: issue generation, issue reduction, and issue selection.
Issues achieving at least 80% consensus and deemed most essential were selected
for future studies. Retained issues were subjected to semiotic analysis, and
preliminary pictograms were developed.
RESULTS: Of the 87 health care professionals (pharmacists, pharmacy technicians,
nurses, and physicians) invited to participate in the Delphi process, 30
participated in all 3 phases. A total of 55 situations that could potentially
benefit from safety pictograms were generated initially. Through the Delphi
process, these were narrowed down to 10 situations where medication safety might
be increased with the use of safety pictograms. For most of the retained issues,
between 3 and 6 pictograms were designed, based on the results of the semiotic
analysis.
CONCLUSIONS: The pharmacists, pharmacy technicians, nurses, and physicians
participating in this study reached consensus and identified 10 medication
administration safety issues that might benefit from the development and
implementation of safety pictograms. Pictograms were developed for a total of 9
issues. In follow-up studies, these pictograms will be validated for
comprehension and evaluated for effectiveness.
Author information:
(1)Cardiovascular Division, The George Institute for Global Health, Sydney,
Australia.
(2)Sydney Medical School, University of Sydney, Sydney, Australia.
(3)Department of Cardiology, Westmead Hospital, Sydney, Australia.
(4)Cardio-respiratory Division, Westmead Institute for Medical Research, Sydney,
Australia.
(5)Statistics Division, The George Institute for Global Health, Sydney,
Australia.
(6)Professorial Unit, The George Institute for Global Health, Sydney, Australia.
© Article author(s) (or their employer(s) unless otherwise stated in the text of
the article) 2017. All rights reserved. No commercial use is permitted unless
otherwise expressly granted.
DOI: 10.1136/bmjopen-2017-017540
PMCID: PMC5640083
PMID: 28993388 [Indexed for MEDLINE]
1142. Rev Lat Am Enfermagem. 2016 Jun 7;24. pii: S0104-11692016000100334. doi:
10.1590/1518-8345.0745.2705.
Liberato AC(1), Rodrigues RC(2), São-João TM(3), Alexandre NM(2), Gallani MC(4).
Author information:
(1)Doctoral student, University of Washington, Seattle, USA., University of
Washington, University of Washington, Seattle , USA.
(2)Associate Professor, Faculdade de Enfermagem, Universidade Estadual de
Campinas, Campinas, SP, Brazil., Universidade Estadual de Campinas, Faculdade de
Enfermagem, Universidade Estadual de Campinas, Campinas SP , Brazil.
(3)Professor, Faculdade de Enfermagem, Universidade Estadual de Campinas,
Campinas, SP, Brazil., Universidade Estadual de Campinas, Faculdade de
Enfermagem, Universidade Estadual de Campinas, Campinas SP , Brazil.
(4)Full Professor, Faculty of Nursing, Laval University, Quebec, Canada., Faculty
of Nursing, Laval University, Quebec , Canada.
Doucette WR(1), Pendergast JF, Zhang Y, Brown G, Chrischilles EA, Farris KB,
Frank J.
Author information:
(1)University of Iowa College of Pharmacy, 115 S Grand Ave, 518 PHAR, Iowa City,
IA 52242-1112. E-mail: william-doucette@uiowa.edu.
Chen PT(1), Wang TJ(2), Hsieh MH(3), Liu JC(4), Liu CY(5), Wang KY(6), Laio
WC(7).
Author information:
(1)Nursing, Cardinal Tien Junior College of Healthcare and Management, Taipei,
Taiwan.
(2)Nursing, National Taipei University of Nursing and Health Sciences, Taipei,
Taiwan tsaejyy@ntunhs.edu.tw.
(3)Cardiology, Taipei Medical University, Taipei, Taiwan.
(4)Internal Medicine, Taipei Medical University Shuang Ho Hospital, New Taipei
City, Taiwan.
(5)Speech Language Pathology and Audiology, National Taipei University of Nursing
and Health Sciences, Taipei, Taiwan.
(6)Nursing, National Defense Medical Center, Taipei, Taiwan.
(7)Nursing, China Medical University, Taichung, Taiwan.
DOI: 10.1136/bmjopen-2019-029974
PMID: 31481562
1145. BMC Health Serv Res. 2014 Nov 26;14:586. doi: 10.1186/s12913-014-0586-1.
Islam SM(1)(2), Lechner A(3), Ferrari U(4), Froeschl G(5), Alam DS(6), Holle
R(7), Seissler J(8), Niessen LW(9).
Author information:
(1)Center for Control of Chronic Diseases, International Center for Diarrhoeal
Diseases Research, Bangladesh (ICDDR,B), 68, Shaheed Tajuddin Ahmed Sarani,
Mohakhali, Dhaka, 1212, Bangladesh. shariful.islam@icddrb.org.
(2)Center for International Health (CIH), Ludwig-Maximilians-Universität (LMU),
Leopoldstrasse 7, 80802, Munich, Germany. shariful.islam@icddrb.org.
(3)Diabetes Center, Diabetes Research Group, Medizinische Klinik und Poliklinik
IV, Ludwig-Maximilians-Universität, Ziemssenstr. 1, 80336, Munich, Germany.
andreas.lechner@med.uni-muenchen.de.
(4)Diabetes Center, Diabetes Research Group, Medizinische Klinik und Poliklinik
IV, Ludwig-Maximilians-Universität, Ziemssenstr. 1, 80336, Munich, Germany.
uta.ferrari@med.uni-muenchen.de.
(5)Center for International Health (CIH), Ludwig-Maximilians-Universität (LMU),
Leopoldstrasse 7, 80802, Munich, Germany. Froeschl@lrz.uni-muenchen.de.
(6)Center for Control of Chronic Diseases, International Center for Diarrhoeal
Diseases Research, Bangladesh (ICDDR,B), 68, Shaheed Tajuddin Ahmed Sarani,
Mohakhali, Dhaka, 1212, Bangladesh. dsalam@icddrb.org.
(7)Economic Evaluations, Helmholtz Zentrum München (GmbH), German Research Center
for Environmental Health, Munich, Germany. holle@helmholtz-muenchen.de.
(8)Diabetes Center, Diabetes Research Group, Medizinische Klinik und Poliklinik
IV, Ludwig-Maximilians-Universität, Ziemssenstr. 1, 80336, Munich, Germany.
jochen.seissler@med.uni-muenchen.de.
(9)Centre for Applied Health Research and Delivery, Liverpool School of Tropical
Medicine, Pembroke Place, Liverpool, L3 5QA, UK. Louis.Niessen@liverpool.ac.uk.
BACKGROUND: Mobile phone technologies including SMS (short message service) have
been used to improve the delivery of health services in many countries. However,
data on the effects of mobile health technology on patient outcomes in
resource-limited settings are limited. The aim of this study therefore is to
measure the impact of a mobile phone SMS service on treatment success of newly
diagnosed type 2 diabetes in an urban area of Bangladesh.
METHODS/DESIGN: This is a single-centred randomized controlled intervention trial
(prospective) comparing standard-of-care with standard-of-care plus a mobile
phone-based SMS intervention for 6 months. A total of 216 participants with newly
diagnosed type 2 diabetes will be recruited. Data will be collected at the
outpatient department of Bangladesh Institute of Health Science (BIHS) hospital
at baseline and after 6 months. The primary outcome measure will be change in
HbA1c between baseline and 6 months. The secondary outcome measures are
self-reported medication adherence, clinic attendance, self-reported adoption of
healthy behaviours, diabetes knowledge, quality of life and cost effectiveness of
the SMS intervention. The inclusion criteria will be as follows: diagnosed as
patients with type 2 diabetes by the BIHS physician, using oral medication
therapy, living in Dhaka city, registered with the BIHS hospital, using a mobile
phone, willing to return for follow up after 6 months and providing written
informed consent. Participants will be allocated to control and intervention arms
after recruitment using a randomization software. Data will be collected on
socio-demographic and economic information, mobile phone use and habits,
knowledge of prevention, management and complications of diabetes, self-perceived
quality of life assessment, self-reported diseases, medical history, family
history of diseases, medication history, medication adherence, health seeking
behaviour, tobacco use, physical activity, diet, mental health status, life
events and disability, anthropometric measurements of weight, height, blood
pressure and blood tests for HbA1c.
DISCUSSION: Mobile phone SMS services have the potential to communicate with
diabetes patients and to build awareness about the disease, improve
self-management and avoid complications also in resource-limited setting. If this
intervention proves to be efficient and cost-effective in the current trial,
large-scale implementation could be undertaken.
TRIAL REGISTRATION: DRKS00005188 .
DOI: 10.1186/s12913-014-0586-1
PMCID: PMC4247872
PMID: 25424425 [Indexed for MEDLINE]
Nazar H(1), Nazar Z(2), Simpson J(3), Yeung A(4), Whittlesea C(1).
Author information:
(1)School of Medicine, Pharmacy and Health, Durham University, Stockton-On-Tees,
UK.
(2)School of Pharmacy and Biomedical Sciences, University of Portsmouth,
Portsmouth, UK.
(3)Clinical Strategy, NHS England North-Cumbria and the North East, Durham, UK.
(4)Senior Specialist Pharmacist Advisor, Northumberland, Tyne and Wear Local
Pharmacy Network, Northumberland, UK.
Erratum in
BMJ Open. 2016 May 20;6(5):e009736corr1.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://www.bmj.com/company/products-services/rights-and-licensing/
DOI: 10.1136/bmjopen-2015-009736
PMCID: PMC4735177
PMID: 26787252 [Indexed for MEDLINE]
Ford JH(1), Foster SA(1), Stauffer VL(1), Ruff DD(1), Aurora SK(1), Versijpt
J(2).
Author information:
(1)Eli Lilly and Company, Indianapolis, IN 46225, USA, ford_janet@lilly.com.
(2)Department of Neurology - Headache and Facial Pain Clinic, Vrije Universiteit
Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), 1090 Brussels,
Belgium.
DOI: 10.2147/PPA.S182563
PMCID: PMC6239121
PMID: 30519007
Conflict of interest statement: Disclosure JHF, SAF, VLS, DDR, and SKA are
full-time employees of Eli Lilly and Company and/or one of its subsidiaries and
may hold company stocks. JV received personal fees and nonfinancial support from
Teva, personal fees from Novartis, and grants and nonfinancial support from
Allergan. The authors report no other conflicts of interest in this work.
Association between anxious symptoms and sleeping medication use among US older
adults.
Author information:
(1)Center for Gerontology and Healthcare Research, School of Public Health, Brown
University, Providence, RI, USA.
(2)Alpert School of Medicine, Brown University, Providence, RI, USA.
(3)Butler Hospital, Providence, RI, USA.
(4)U.S. Department of Veterans Affairs Medical Center, Providence, RI, USA.
OBJECTIVE: To investigate the relationship between anxiety symptoms and sleeping
medication use among a nationally representative sample of US older adults.
DESIGN: Cross-sectional design using data from the 2011 National Health and Aging
Trends Study to examine the relationship between anxiety symptoms as rated by the
Generalized Anxiety Disorder-2 and self-reported sleeping medication use. Survey
weights were applied to account for complex survey design. Logistic regression
was used to measure the association between anxiety symptoms and sleeping
medication use after adjusting for sociodemographic factors, physical health, and
other sleep-related issues.
RESULTS: In 2011, 13.1% of respondents experienced high anxiety symptoms and
29.0% reported taking a sleeping medication at least once a week during the last
30 days. Results estimate that approximately 4 million US older adults have
clinically significant anxiety symptoms and approximately 10 million US older
adults used a sleeping medication in the last 30 days. Adjusted results revealed
that high anxiety symptoms are significantly associated with sleeping medication
use compared to low anxiety symptoms (AOR = 1.57; 95% CI, 1.29-1.91). Depression
symptoms were also associated with sleeping medication (AOR = 1.29; 95% CI,
1.08-1.55).
CONCLUSIONS: Results demonstrated that anxiety symptoms are significantly
associated with sleeping medication use among US older adults. We also found that
depressive symptoms, chronic conditions, and worse self-rated health are
associated with sleeping medication use. As sleeping medications are associated
with adverse health events, these results have clinical implications for treating
anxiety symptoms among older patients.
DOI: 10.1002/gps.4795
PMCID: PMC5773373
PMID: 28960462 [Indexed for MEDLINE]
Torre C(1)(2), Guerreiro J(1), Longo P(1), Raposo JF(3)(4), Leufkens H(5),
Martins AP(2)(6).
Author information:
(1)Centre for Health Evaluation & Research (CEFAR), National Association of
Pharmacies, Lisboa, Portugal, carla.torre@campus.ul.pt.
(2)Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy,
University of Lisbon, Lisboa, Portugal, carla.torre@campus.ul.pt.
(3)Nova Medical School, New University of Lisbon, Lisboa, Portugal.
(4)Portuguese Diabetes Association (APDP), Lisboa, Portugal.
(5)Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute
for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.
(6)Faculty of Pharmacy, University of Lisbon, Lisboa, Portugal.
DOI: 10.2147/PPA.S170134
PMCID: PMC6103301
PMID: 30147305
Author information:
(1)Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen,
40002, Thailand.
BACKGROUND: Previous Thai surveys of asthma care have shown suboptimal management
and poor control. Since then several editions of the Thailand National Asthma
Guidelines have been distributed to help improve asthma control. A new survey was
undertaken to see if any improvement in care had occurred. It examined patients'
insights, attitudes and perceptions about their asthma and its treatment.
METHODS: Asthma patients (>12 years) were randomly selected and participated in
face-to-face interviews. Patients answered 53 questions exploring general health,
diagnosis, symptoms, exacerbations, patient burden, disease management, treatment
and attitudes. The Global Initiative for Asthma guidelines were used to assess
asthma control.
RESULTS: Data were obtained from 400 asthma patients from 8,177 screened
households. This showed that 36% had had exacerbations in the previous year, 17%
had been hospitalized and 35% had had an unscheduled emergency visit to hospital
or a doctor's office or clinic. Work or school was missed by 44% due to asthma
while a similar number had had an asthma episode that made them feel their life
was in danger. Only 8% had good asthma control. Patients had low expectations
with respect to asthma treatment and their understanding of how to use therapies
was poor. Forty-four percent of participants reported day-time symptoms and about
one-third (34%) of adults and adolescents in the survey reported night-time
symptoms at least once a week in the previous 4 weeks. Asthma patients in
Thailand rated their average productivity when asthma was at its worst at 48%, on
a scale of 0 to 100%, which equates to a 36% decline in productivity. Rescue
medication during the previous four weeks had been used by 44% of asthma patients
while 54% had used a controller medication. Pill controller medication is the
most used form among those reporting controller medication use (67%), whereas 57%
reported taking an inhaler. Oral steroids had been used in the previous 12 months
by 40% of patients with the average number for 3 day or longer at 24 times, while
the median was about 4 times.
CONCLUSIONS: Asthma had a profound impact on patients' wellbeing, despite the
availability of effective treatments and evidence-based management guidelines. A
large proportion of asthma patients overestimate their asthma control and have
inappropriate concepts about asthma treatment. Gaining better insight into
patient's attitudes about self-care is critical to improve asthma management.
DOI: 10.12932/AP0473.33.1.2015
PMID: 25840629 [Indexed for MEDLINE]
Author information:
(1)Department of Occupational and Environmental Health, Xiangya School of Public
Health, Central South University, Changsha, Hunan Province, 410078, China.
(2)Department of Nutrition and Food Hygiene, Xiangya School of Public Health,
Central South University, Changsha, Hunan Province, 410078, China.
renguofeng@csu.edu.cn.
(3)Department of Occupational and Environmental Health, Xiangya School of Public
Health, Central South University, Changsha, Hunan Province, 410078, China.
huja_xy@126.com.
DOI: 10.1186/s13063-017-1996-2
PMCID: PMC5496390
PMID: 28673323 [Indexed for MEDLINE]
Author information:
(1)Health Equity and Rural Outreach Innovation Center (HEROIC), Charleston VA
HSR&D COIN, Ralph H. Johnson VAMC, Charleston, SC, USA; Center for Health
Disparities Research, Medical University of South Carolina, Charleston, SC, USA;
Department of Health Science and Research, Medical University of South Carolina,
Charleston, SC, USA.
(2)Health Equity and Rural Outreach Innovation Center (HEROIC), Charleston VA
HSR&D COIN, Ralph H. Johnson VAMC, Charleston, SC, USA; Division of Public Health
Sciences, Department of Medicine, Medical University of South Carolina,
Charleston, SC, USA.
(3)Department of Health Science and Research, Medical University of South
Carolina, Charleston, SC, USA; Department of Otolaryngology-Head and Neck
Surgery, Medical University of South Carolina, Charleston, SC, USA.
(4)Health Equity and Rural Outreach Innovation Center (HEROIC), Charleston VA
HSR&D COIN, Ralph H. Johnson VAMC, Charleston, SC, USA; Center for Health
Disparities Research, Medical University of South Carolina, Charleston, SC, USA;
Division of General Internal Medicine and Geriatrics, Department of Medicine,
Medical University of South Carolina, Charleston, SC, USA. Electronic address:
egedel@musc.edu.
OBJECTIVE: To develop and test latent variables of the social determinants of
health that influence diabetes self-care.
METHODS: 615 adults with type 2 diabetes were recruited from two adult primary
care clinics in the southeastern United States. Confirmatory factor analyses
(CFA) identified the latent factors underlying socioeconomic determinants,
psychosocial determinants, and self-care (diet, exercise, foot care, glucose
testing, and medication adherence). Structured equation modeling (SEM)
investigated the relationship between determinants and self-care.
RESULTS: Latent variables were created for diabetes self-care, psychological
distress, self-efficacy, social support and social status. The initial model
(chi2(254) = 388.04, p < 0.001, RMSEA = 0.03, CFI = 0.98) showed that lower
psychological distress (r = -0.13, p = 0.019), higher social support (r = 0.15, p
= 0.008), and higher self-efficacy (r = 0.47, p < 0.001) were significantly
related to diabetes self-care. Social status was not significantly related to
self-care (r = 0.003, p = 0.952). In the trimmed model (chi2(189) = 211.40, p =
0.126, RMSEA = 0.01, CFI = 0.99) lower psychological distress (r = -0.13, p =
0.016), higher social support (r = 0.15, p = 0.007), and higher self-efficacy (r
= 0.47, p < 0.001) remained significantly related to diabetes self-care.
CONCLUSION: Based on theoretical relationships, three latent factors that measure
social determinants of health (psychological distress, social support and
self-efficacy) are strongly associated with diabetes self-care.
PRACTICE IMPLICATIONS: This suggests that social determinants should be taken
into account when developing patient self-care goals.
DOI: 10.1016/j.pec.2014.10.002
PMCID: PMC4314329
PMID: 25455793 [Indexed for MEDLINE]
Kazemi Shishavan M(1), Asghari Jafarabadi M(2)(3), Aminisani N(3), Shahbazi M(4),
Alizadeh M(5).
Author information:
(1)Department of Community and Family Medicine, Tabriz University of Medical
Sciences, Tabriz, Iran.
(2)Road Traffic Injury Research Center, Tabriz University of Medical Sciences,
Tabriz, Iran.
(3)Department of Statistics and Epidemiology, Tabriz University of Medical
Sciences, Tabriz, Iran.
(4)School of Public Health, Professor Jackson State University, Jackson,
Mississippi, USA.
(5)Social Determinants of Health Research Center, Department of Community and
Family Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
DOI: 10.15171/hpp.2018.18
PMCID: PMC5935818
PMID: 29744310
Yan BD(1), Meng SS(1)(2), Ren J(1), Lv Z(3), Zhang QH(1), Yu JY(1), Gao R(1), Shi
CM(4), Wu CF(5), Liu CL(6), Zhang J(1), Ma ZS(1), Liu J(7).
Author information:
(1)The Department of Respiratory Medicine, The Second Hospital of Jilin
University, Changchun, China.
(2)Department of Critical Care Medicine, Zhongda Hospital, School of Medicine,
Southeast University, Nanjing, China.
(3)The Tumor Centre, The First Hospital of Jilin University, Changchun, China.
(4)The Department of Respiratory Medicine, China-Japan Union Hospital of Jilin
University, Changchun, China.
(5)The Department of Respiratory Medicine, The People's Hospital of Jilin
Province, Changchun, China.
(6)The Department of Respiratory Medicine, The 208th Hospital of the Chinese
People's Liberation Army, Changchun, China.
(7)The Department of Respiratory Medicine, The Second Hospital of Jilin
University, Changchun, China. liujing020901@163.com.
DOI: 10.1186/s12890-016-0292-3
PMCID: PMC5006269
PMID: 27577233 [Indexed for MEDLINE]
Author information:
(1)Department of Psychiatry, St. John's Medical College, Bengaluru, Karnataka,
India.
(2)Department of Endocrinology, St. John's Medical College, Bengaluru, Karnataka,
India.
DOI: 10.4103/IJPSYM.IJPSYM_455_18
PMCID: PMC6657474
PMID: 31391669
Thach AV, Brown CM, Herrera V, Sasane R, Barner JC, Ford KC, Lawson KA.
DOI: 10.7224/1537-2073.2017-031
PMCID: PMC6295882
PMID: 30568562
Lee YC(1), Ward McIntosh C(2), Winston F(3), Power T(2), Huang P(2), Ontañón
S(4), Gonzalez A(5).
Author information:
(1)George Mason University, USA.
(2)Children's Hospital of Philadelphia, USA.
(3)Children's Hospital of Philadelphia and University of Pennsylvania, USA.
(4)Drexel University, USA.
(5)University of Central Florida, USA.
The diagnosis of ADHD among teens and young adults has been associated with a
higher likelihood of motor vehicle crashes. Some studies suggest a beneficial
effect of ADHD medication but the exact efficacy is still being debated. Further,
medication adherence, which is low in this age group, can further reduce
effectiveness. Our long-term objective is to reduce unsafe driving among drivers
with ADHD by detecting medication non-adherence through driver behavior modeling
and monitoring. As a first step, we developed the described lab study protocol to
obtain reliable driver behavior data that will then be used to design and train
behavior models built through machine learning. This experimental study protocol
was developed to systematically compare driving behaviors under two medication
conditions (before and after intake of medication) among young adults with ADHD
and a control group of non-ADHD. A driving simulator was used to examine driving
behaviors and interactions with traffic. The primary outcome was speed management
for two comparisons (ADHD vs. non-ADHD and before vs. after medication), and
secondary objectives involved understanding differences among the participants
utilizing self-reported surveys about ADHD symptoms, drivers' knowledge, and
perception about safety. The study protocol was designed to maximize participant
safety and efficiency of data collection, as multiple measures were collected
over two 2-h study visits. The sampled ADHD drivers were demographically and
psychosocially similar but clinically different from the non-ADHD group. Overall,
this protocol was effective in participant recruitment and retention, allowed
staggered data collection, and can be incorporated in a subsequent clinical trial
that examines the efficacy of a machine-learning based driver monitoring
intervention.
DOI: 10.1016/j.conctc.2018.07.007
PMCID: PMC6082792
PMID: 30101205
Arentsen TJ(1), Panos S(2)(3), Thames AD(3), Arbid JN(4), Castellon SA(2)(3),
Hinkin CH(2)(3).
Author information:
(1)Memphis Veterans Affairs Medical Center, Memphis, TN.
(2)VA Greater Los Angeles Healthcare System, Los Angeles CA.
(3)University of California, Los Angeles, Psychiatry and Biobehavioral Sciences,
Los Angeles CA.
(4)University of Massachusetts Boston, Boston MA.
DOI: 10.1080/15381501.2016.1228309
PMCID: PMC5509354
PMID: 28713226
Author information:
(1)School of Health & Biomedical Sciences, RMIT University, Bundoora, Victoria
3083, Australia.
DOI: 10.2147/PPA.S212046
PMCID: PMC6611718
PMID: 31303749
Concurrent alcohol and medication poisoning hospital admissions among older rural
and urban residents.
Zanjani F(1), Smith R(2), Slavova S(3), Charnigo R(3), Schoenberg N(4), Martin
C(5), Clayton R(6).
Author information:
(1)a Behavioral and Community Health, School of Public Health , University of
Maryland , College Park , MD , USA.
(2)b Epidemiology , University of Kentucky , Lexington , KY , USA.
(3)c Biostatistics , University of Kentucky , Lexington , KY , USA.
(4)d Behavioral Science , University of Kentucky , Lexington , KY , USA.
(5)e Psychiatry , University of Kentucky , Lexington , KY , USA.
(6)f Health Behavior , University of Kentucky , Lexington , KY , USA.
DOI: 10.3109/00952990.2016.1154966
PMCID: PMC4998842
PMID: 27184414 [Indexed for MEDLINE]
1161. Ther Adv Drug Saf. 2016 Aug;7(4):159-64. doi: 10.1177/2042098616651198. Epub
2016
May 20.
Making rational choices about how best to support consumers' use of medicines: a
perspective review.
Author information:
(1)Centre for Health Communication and Participation, School of Psychology and
Public Health, College of Science, Health and Engineering, La Trobe University,
Victoria 3086, Australia.
(2)Centre for Health Communication and Participation, School of Psychology and
Public Health, College of Science, Health and Engineering, La Trobe University,
Victoria, Australia.
DOI: 10.1177/2042098616651198
PMCID: PMC4959633
PMID: 27493719
Zhang Y(#)(1), Li X(#)(1), Mao L(1), Zhang M(1), Li K(1), Zheng Y(1), Cui W(1),
Yin H(1), He Y(1), Jing M(1).
Author information:
(1)Department of Public Health, Shihezi University School of Medicine, Shihezi,
Xinjiang, China.
(#)Contributed equally
DOI: 10.2147/PPA.S158662
PMCID: PMC5955046
PMID: 29785095
Author information:
(1)Department of Social and Preventive Medicine, University of Malaya, Kuala
Lumpur, Malaysia ; Ministry of Health Malaysia, Putrajaya, Malaysia.
(2)Department of Social and Preventive Medicine, University of Malaya, Kuala
Lumpur, Malaysia ; Centre for Population Health, Faculty of Medicine, University
of Malaya, Kuala Lumpur, Malaysia.
PURPOSE: The aim of this study was to explore patients' experiences with their
illnesses and the reasons which influenced them in not following hypertensive
care recommendations (antihypertensive medication intake, physical activity, and
diet changes) in primary health clinic settings.
PATIENTS AND METHODS: A qualitative methodology was applied. The data were
gathered from in-depth interviews with 25 hypertensive patients attending
follow-up in nine government primary health clinics in two districts (Hulu Langat
and Klang) in the state of Selangor, Malaysia. The transcribed data were analyzed
using thematic analysis.
RESULTS: There was evidence of lack of patient self-empowerment and community
support in Malaysian society. Most of the participants did not take their
antihypertensive medication or change their physical activity and diet after
diagnosis. There was an agreement between the patients and the health care
professionals before starting the treatment recommendation, but there lacked
further counseling and monitoring. Most of the reasons given for not taking
antihypertensive medication, not doing physical activity and not following diet
recommendations were due to side effects or fear of the side effects of
antihypertensive medication, patients' attitudes, lack of information from health
care professionals and insufficient social support from their surrounding
environment. We also observed the differences on these reasons for nonadherence
among the three ethnic groups.
CONCLUSION: Health care professionals should move toward supporting adherence in
the management of hypertensive patients by maintaining a dialogue. Patients need
to be given time to enable them to overcome their inhibition of asking questions
and to accept the recommendations. A self-management approach must be responsive
to the needs of individuals, ethnicities, and communities.
DOI: 10.2147/PPA.S69680
PMCID: PMC4240212
PMID: 25484577
Author information:
(1)Department of Clinical Pharmacy, School of Pharmacy, College of Health
Sciences, Mekelle University, Mekelle, Tigray, Ethiopia.
(2)Clinical Pharmacy and Pharmacy Practice Unit, Departments of Pharmacy, College
of Health Sciences, Aksum University, Aksum, Tigray, Ethiopia.
Background: Medication adherence and belief are crucial to achieving the desired
goal of therapy in epileptic patients. However, there is a lack of study
regarding medication adherence and belief in our setting. Therefore, the purpose
of this study was to investigate medication adherence and belief and associated
factors among ambulatory patients with epilepsy.
Method: A cross-sectional study was conducted on randomly selected epileptic
patients at the neurologic clinic of Ayder Comprehensive Specialized Hospital,
Ethiopia. Medication adherence and belief were assessed using self-reported
questionnaires which were developed based on the review of different literatures.
Data were analyzed using binary logistic regression analysis.
Result: We included a total of 292 patients. Almost two-thirds (65.4%) of the
patients were nonadherent to their medications. The most common cause of
nonadherence was forgetfulness (48.7%) followed by inability to get medicine
(28.8) and safety concern (23.5%). The majority (78.4%) of the patients had high
medication necessity belief while 44.1% had high concern belief about the
potential adverse effect of their medications. Overall, 39.4% of the patients had
a negative belief toward their medications. Comorbidity (AOR: 3.51, 95% CI:
1.20-10.31), seizure encounter within the last 3 months (AOR: 5.45, 95% CI:
2.48-12.00), low medication necessity belief (AOR: 3.38, 95% CI: 1.14-10.00),
high medication concern belief (AOR: 4.23, 95% CI: 2.07-8.63), and negative
medication belief (AOR: 4.17, 95% CI: 1.74-10.02) were predictors of medication
nonadherence.
Conclusion: Majority of the epileptic patients were nonadherent to their
medications, and more than one-third of the patients had a negative medication
belief. Low medication necessity belief, high medication concern belief, negative
medication belief, comorbidity, and seizure encounter were predictors of
medication nonadherence. Therefore, healthcare providers should design
educational programs to enhance the patients' believe about their medication in
order to improve medication adherence and overall treatment outcome.
DOI: 10.1155/2019/2806341
PMCID: PMC6507244
PMID: 31178940
1165. Int J Ther Massage Bodywork. 2016 Sep 9;9(3):27-30. eCollection 2016 Sep.
Case Study: The Use of Massage Therapy to Relieve Chronic Low-Back Pain.
Allen L.
PMCID: PMC5017818
PMID: 27648110
Author information:
(1)School of Nursing and Midwifery. Department of Medical-Surgical Nursing,
Mazandaran Pediatric Infectious Disease Research Center (MPIDRC), Mazandaran
University of Medical Sciences, Sari, Iran.
(2)Nasibeh School of Nursing and Midwifery, Mazandaran University of Medical
Sciences. Sari, Iran.
BACKGROUND AND OBJECTIVES: The dangerous events caused by medication errors are
one of the main challenges faced in critical care units. The present study was
conducted to determine the frequency of intravenous medication administration
errors and their causes in cardiac critical care units in Iran.
MATERIALS AND METHODS: The present descriptive study was conducted in the
critical care units (CCUs and cardiac surgery intensive care units) of 12
teaching hospitals. Of the total of 240 nurses working in these departments, 190
participated in the present study. The data collection tools used in this study
included the "nurses' demographic data questionnaire", the "patients' medical and
demographic data questionnaire" and the "nurses' self-reporting questionnaire
about the frequency of intravenous medication administration errors and their
causes". The data obtained were analyzed in SPSS-20 using descriptive statistics
such as the absolute and relative frequency.
FINDINGS: During the 2 months in which this study was being conducted, 2542
patients were admitted to these departments and 20240 doses of intravenous
medications were administered to these patients. The nurses reported 262
intravenous medication administration errors. The most common intravenous
medication error pertained to administering the wrong medication (n=71 and
27.1%). As for the causes of intravenous medication administration errors, 51.5%
of the errors were associated with work conditions, 24% with packaging, 13.4%
with communication, 9.9% with transcription and 1.2% with pharmacies.
DISCUSSION AND CONCLUSION: According to the results, strategies are recommended
to be adopted for reducing or limiting medication errors, such as building a
stronger pharmacology knowledge base in nurses and nursing students, improving
work conditions and improving communication between the nurses and physicians.
DOI: 10.5455/msm.2015.27.442-446
PMCID: PMC4733547
PMID: 26889108
Uludag A(1), Sahin EM(1), Agaoglu H(1), Gungor S(1), Ertekin YH(1), Tekin M(1).
Author information:
(1)Department of Family Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart
University, Çanakkale, Turkey.
DOI: 10.4103/1119-3077.180060
PMID: 27251960 [Indexed for MEDLINE]
Menditto E(1), Guerriero F(1), Orlando V(1), Crola C(2), Di Somma C(3), Illario
M(2), Morisky DE(4), Colao A(5).
Author information:
(1)Center of Pharmacoeconomics (CIRFF), Federico II University, 80131 Naples,
Italy.
(2)Research and Development Board, Federico II University Hospital, 80131 Naples,
Italy ; Translational Medical Sciences (DISMET), Federico II University, 80131
Naples, Italy.
(3)IRCCS SDN, 80131 Naples, Italy.
(4)Department of Community Health Sciences, UCLA Fielding School of Public
Health, Los Angeles, CA 90095-1772, USA.
(5)Department of Clinical Medicine and Surgery, Federico II University, 80131
Naples, Italy.
Objectives. The aim of the study was to assess self-reported medication adherence
measure in patients selected during a health education and health promotion
focused event held in the Campania region. The study also assessed
sociodemographic determinants of adherence. Methods. An interviewer assisted
survey was conducted to assess adherence using the Italian version of the 8-item
Morisky Medication Adherence Scale (MMAS-8). Participants older than 18 years
were interviewed by pharmacists while waiting for free-medical checkup. Results.
A total of 312 participants were interviewed during the Health Campus event. A
total of 187 (59.9%) had low adherence to medications. Pearson's bivariate
correlation showed positive association between the MMAS-8 score and gender,
educational level and smoking (P < 0.05). A multivariable analysis showed that
the level of education and smoking were independent predictors of adherence.
Individuals with an average level of education (odds ratio (OR), 2.21, 95%
confidence interval (CI), 1.08-4.52) and nonsmoker (odds ratio (OR) 1.87, 95%
confidence interval (CI), 1.04-3.35) were found to be more adherent to medication
than those with a lower level of education and smoking. Conclusion. The analysis
showed very low prescription adherence levels in the interviewed population. The
level of education was a relevant predictor associated with that result.
DOI: 10.1155/2015/682503
PMCID: PMC4541012
PMID: 26346487
Palumbo R(1).
Author information:
(1)Department of Management and Information Technology, University of Salerno,
Salerno, Italy.
DOI: 10.15171/ijhpm.2015.95
PMCID: PMC4493582
PMID: 26188806 [Indexed for MEDLINE]
Author information:
(1)School of Pharmacy, University of Nizwa, Nizwa, Oman.
(2)Department of General Medicine, Nizwa Hospital, Nizwa, Oman.
DOI: 10.5001/omj.2019.64
PMCID: PMC6642718
PMID: 31360322
1171. Int J Clin Health Psychol. 2015 May-Aug;15(2):121-129. doi:
10.1016/j.ijchp.2014.11.003. Epub 2014 Dec 25.
Author information:
(1)Universidad de La Laguna, Spain.
Author information:
(1)Division of Behavioral Medicine and Clinical Psychology.
(2)Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital
Medical Center.
© The Author 2017. Published by Oxford University Press on behalf of the Society
of Pediatric Psychology. All rights reserved. For permissions, please e-mail:
journals.permissions@oup.com
DOI: 10.1093/jpepsy/jsx090
PMCID: PMC5896586
PMID: 29049791
Kim CY(1), Park KH(2), Ahn J(3), Ahn MD(4), Cha SC(5), Kim HS(6), Kim JM(7), Kim
MJ(8), Kim TW(9), Kim YY(10), Lee JW(11), Park SW(12), Sohn YH(13), Sung KR(14),
Yoo C(15), Cha J(16), Kim YJ(16).
Author information:
(1)Institute of Vision Research, Department of Ophthalmology, Yonsei University
College of Medicine, Seoul, Republic of Korea.
(2)Department of Ophthalmology, Seoul National University Hospital, Seoul,
Republic of Korea.
(3)Ajou University School of Medicine, Suwon, Republic of Korea.
(4)Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic
of Korea.
(5)Department of Ophthalmology, Yeungnam University College of Medicine, Daegu,
Republic of Korea.
(6)Sungmo Eye Hospital, Busan, Republic of Korea.
(7)Department of Ophthalmology, Sungkyunkwan University School of Medicine,
Kangbuk Samsung Hospital, Seoul, Republic of Korea.
(8)Kong Eye Clinic, Seoul, Republic of Korea.
(9)Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.
(10)Korea University Guro Hospital, Seoul, Republic of Korea.
(11)Pusan National University Hospital, Busan, Republic of Korea.
(12)Chonnam National University Medical School & Hospital, Gwangju, Republic of
Korea.
(13)Kim's Eye Hospital, Seoul, Republic of Korea.
(14)Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic
of Korea.
(15)Korea University Anam Hospital, Seoul, Republic of Korea.
(16)Pfizer Pharmaceutical Korea Limited, Seoul, Republic of Korea.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://www.bmj.com/company/products-services/rights-and-licensing/.
DOI: 10.1136/bjophthalmol-2016-308505
PMCID: PMC5583683
PMID: 28270490 [Indexed for MEDLINE]
Marek KD(1), Stetzer F, Adams SJ, Bub LD, Schlidt A, Colorafi KJ.
Author information:
(1)College of Nursing and Health Innovation, Arizona State University, Phoenix,
Arizona.
Comment in
J Am Geriatr Soc. 2014 Dec;62(12):2433-5.
DOI: 10.1111/jgs.13162
PMCID: PMC4383646
PMID: 25482242 [Indexed for MEDLINE]
Author information:
(1)Winkle College of Pharmacy, University of Cincinnati, 3225 Eden Ave.,
Cincinnati, OH, 45267. Ana.Hincapie@uc.edu.
DOI: 10.18553/jmcp.2015.21.5.391
PMID: 25943000 [Indexed for MEDLINE]
Lind KB(1), Soerensen CA(2), Salamon SA(3), Jensen TM(1), Kirkegaard H(4), Lisby
M(4).
Author information:
(1)Emergency Department, Randers Regional Hospital, Randers, Denmark.
(2)Randers Department, Hospital Pharmacy Central Denmark Region, Randers,
Denmark.
(3)Department of Emergency Medicine, Aalborg University Hospital, Aalborg,
Denmark.
(4)Research Center for Emergency Medicine, Aarhus University Hospital, Aarhus,
Denmark.
DOI: 10.1136/ejhpharm-2015-000767
PMCID: PMC6451522
PMID: 31156841
Bautista RED(1).
Author information:
(1)Comprehensive Epilepsy Program, Department of Neurology, University of Florida
Health Sciences Center/Jacksonville, United States. Electronic address:
ramon.bautista@jax.ufl.edu.
DOI: 10.1016/j.yebeh.2016.11.022
PMID: 28219044 [Indexed for MEDLINE]
Author information:
(1)Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of
Science and Technology, Irbid 22110, Jordan.
(2)Faculty of Pharmacy, Al-Quds University, Palestinian Territories, Israel.
DOI: 10.1016/j.jsps.2018.01.013
PMCID: PMC5856954
PMID: 29556120
1179. J Clin Med Res. 2015 Oct;7(10):791-4. doi: 10.14740/jocmr2284w. Epub 2015 Aug
23.
Maternal Uncontrolled Anxiety Disorders Are Associated With the Increased Risk of
Hypertensive Disorders in Japanese Pregnant Women.
Author information:
(1)Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika
Maternity Hospital, Tokyo, Japan.
DOI: 10.14740/jocmr2284w
PMCID: PMC4554219
PMID: 26346308
McGillicuddy J(1), Chandler J(2), Sox L(2), Mueller M(2), Nemeth L(2), Baliga
P(1), Treiber F(2).
Author information:
(1)College of Medicine, Medical University of South Carolina, Charleston, SC,
United States.
(2)College of Nursing, Medical University of South Carolina, Charleston, SC,
United States.
©John McGillicuddy, Jessica Chandler, Luke Sox, Martina Mueller, Lynne Nemeth,
Prabhakar Baliga, Frank Treiber. Originally published in JMIR Research Protocols
(http://www.researchprotocols.org), 21.06.2019.
DOI: 10.2196/13351
PMCID: PMC6611329
PMID: 31228175
Author information:
(1)Biomedical Research and Innovation Incubation Center, MacKay Memorial
Hospital, Taipei, Taiwan.
(2)Department of Emergency, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical
Foundation, Chiayi, Taiwan.
(3)School of Medicine, Tzu Chi University, Hualien, Taiwan.
(4)Department of Medicine, MacKay Medical College, New Taipei City, Taiwan.
(5)Department of Emergency, MacKay Memorial Hospital, Taipei, Taiwan.
(#)Contributed equally
BACKGROUND: Mobile health (mHealth) apps have recently demonstrated the potential
to engage and empower people to improve their own health. Although the
availability of health-related apps is increasing, their adoption rate in Taiwan
is exceptionally low mainly due to the preponderance of Western culture-based app
designs that are challenging for non-English-speaking individuals. To our
knowledge, no mHealth app is available in Taiwan that is culturally tailored for
Chinese-speaking users and that applies a patient-centered approach to
self-manage medication and health.
OBJECTIVE: The purpose of this study was to design and deploy a culturally
tailored mHealth system that could be easily integrated into current clinical
practice and to evaluate how this mHealth system could support the continuity of
patient care in Taiwan.
METHODS: An mHealth information system and a mobile app were designed. To promote
the best patient experience, a Quick Response (QR) code system was developed to
enable efficient registration of personal medication information through the
mobile app. The app also supported notifications for drug utilization, refills,
and symptom checks. Patients were encouraged to record medication use, symptoms,
and self-assessments in the app during their treatment period. Evaluation of the
novel mHealth system was conducted from August 1, 2016 to December 31, 2016 at
MacKay Memorial Hospital, Taipei, Taiwan. Population data and app usage
statistics were analyzed.
RESULTS: During the 5-month implementation period, a total of 25,909 users
downloaded the app with an overall 7-day retention rate of 15.4% (SD 3.9). Young
male adults (range 25-44 years) were the predominant user population. Patients'
feedback on app usability and design, QR code system as drug input method,
medication reminders, and linking family or friends into care networks was
generally positive. Physicians showed great interest in utilizing
patient-generated data in their care process, and the positive medication
adherence rate was the most highly valued component of this system.
CONCLUSIONS: This pilot study demonstrated the value of a novel mHealth approach
for individualized medication and health management in Taiwan. The mHealth system
shows the potential to optimize personalized care into existing clinical services
and may help hospitals and health authorities perform continuous quality
improvement and policy development.
DOI: 10.2196/mhealth.9987
PMCID: PMC6053609
PMID: 29970356
Ueno H(1), Ishikawa H(1)(2), Suzuki R(3)(4), Izumida Y(3), Ohashi Y(5), Yamauchi
T(3), Kadowaki T(3)(6)(7), Kiuchi T(1).
Author information:
(1)Department of Health Communication, School of Public Health, Graduate School
of Medicine, The University of Tokyo, Tokyo, Japan.
(2)Graduate School of Public Health, Teikyo University, Tokyo, Japan.
(3)Department of Diabetes and Metabolic Diseases, Graduate School of Medicine,
The University of Tokyo, Tokyo, Japan.
(4)Division of Diabetes, Metabolism, Endocrinology, Rheumatology and Collagen
Diseases Tokyo Medical University, Tokyo, Japan.
(5)Nursing Department, The University of Tokyo Hospital, Tokyo, Japan.
(6)Department of Prevention of Diabetes and Life-style Related Diseases, Graduate
School of Medicine, The University of Tokyo, Tokyo, Japan.
(7)Department of Metabolism and Nutrition, Mizonokuchi Hospital, Teikyo
University, Kawasaki, Kanagawa, Japan.
Objectives: The aim of this study is to empirically examine a full pathway model
of health literacy, and health and well-being outcomes among patients with type 2
diabetes.
Methods: A three-wave longitudinal survey was administered to 148 patients with
diabetes. Covariance structure analysis was conducted to create a path diagram,
with health literacy and burden of medical expenses included as independent
variables and with psychosocial factors, behaviors, and health and well-being
outcomes included as dependent variables.
Results: The model fit indices showed a comparative fit index of 0.985 at
baseline, 0.959 after 3 months, and 0.948 after 6 months, with a root mean square
error of approximation of 0.040 at baseline, 0.079 after 3 months, and 0.085
after 6 months. There were 14 significant paths across the three time points
between health literacy and understanding of diabetes care, self-efficacy,
communication with doctors, and medication adherence.
Conclusion: The model fitness index showed an adequate result. Health literacy
was significantly positively associated with understanding of diabetes care,
self-efficacy, communication with doctors, and medication adherence. Health
literacy had a direct positive influence on medication adherence and possibly an
indirect positive influence on exercise/diet via self-efficacy. The results were
generally consistent across the three time points, suggesting good reliability of
the models. Improving health literacy may lead to better self-management of
diabetes and favorable health outcomes.
DOI: 10.1177/2050312119865647
PMCID: PMC6651654
PMID: 31384463
Author information:
(1)Department for Endocrinology, Diabetes and Metabolic Diseases, Avicenne
Hospital, APHP, Bobigny, France, gerard.reach@aphp.fr.
(2)EA 3412, Health Education and Practices Laboratory (LEPS), Paris 13
University, Sorbonne Paris Cité, Bobigny, France, gerard.reach@aphp.fr.
(3)Clinical Research Unit and Clinical Research Center, Avicenne Hospital, APHP,
Bobigny, France.
(4)INSERM UMR 1153 (Centre of Research in Epidemiology and Statistics, Sorbonne
Paris Cité), ECSTRRA team (Epidemiology and Clinical Statistics for Tumor,
Respiratory, and Ressuscitation Assessments), Hôpital Saint Louis, Paris, France.
DOI: 10.2147/PPA.S180280
PMCID: PMC6234996
PMID: 30519002
Author information:
(1)Department of Medicine, Department of Biomedical Informatics, Center for
Health and Health Education, Vanderbilt University Medical Center, 2525 West End
Ave. Suite 370, Nashville, TN, 37203, USA. chandra.osborn@vanderbilt.edu.
(2)Ferkauf Graduate School of Psychology, Yeshiva University, New York, NY, USA.
(3)Diabetes Research Center, Albert Einstein College of Medicine, New York, NY,
USA.
Erratum in
J Behav Med. 2016 Aug;39(4):733.
DOI: 10.1007/s10865-016-9741-y
PMCID: PMC4945416
PMID: 27062271 [Indexed for MEDLINE]
1185. BMC Health Serv Res. 2017 Aug 9;17(1):547. doi: 10.1186/s12913-017-2462-2.
Author information:
(1)Centre for Medication Safety and Service Quality, Imperial College Healthcare
NHS Trust, London, UK. seetal.jheeta@nhs.net.
(2)Centre for Medication Safety and Service Quality, Imperial College Healthcare
NHS Trust, London, UK.
(3)Research Department of Practice and Policy, UCL School of Pharmacy, London,
UK.
BACKGROUND: The aim of the study was to explore the impact of the implementation
of an electronic prescribing and medication administration system (ePA) on the
safety of medication administration in an inpatient hospital setting. Objectives
were to compare the prevalence and types of: 1) medication administration errors,
and 2) documentation discrepancies, between a paper and an ePA system.
Additionally, we wanted to describe any observed changes to medication
administration practices.
METHODS: The study was based on an elderly medicine ward in an English hospital.
From December 2014 to June 2015, nurses' medication administration rounds were
observed every 5 days before and after ePA implementation using an interrupted
time-series approach. Medication administration error and documentation
discrepancy rates pre- versus post-ePA were analysed descriptively and
chi-squared tests used to test for any difference; segmented regression analysis
was used to determine changes in longitudinal trend.
RESULTS: Observations were made at 15 pre- and 15 post-ePA implementation
time-points. Pre-ePA on paper, there were 18 medication administration errors in
428 opportunities for error (4.2%; 95% confidence interval 2.3-6.1%), and with
ePA there were 18 in 528 (3.4%; 95% confidence interval 1.9-5.0%; p = 0.64).
Regarding documentation, pre-ePA on paper there were 5 discrepancies in 460
observed documentations (1.1%; 95% confidence interval 0.1-2.0%); with ePA there
were 18 in 557 (3.2%; 95% confidence interval 1.8-4.7%; p = 0.04). The most
common electronic documentation discrepancy was documentation that a dose had
been administered when it had not. Segmented regression analysis was unable to
detect any significant longitudinal changes. Changes to working practices
post-ePA were observed, such as nurses demonstrating less-consistent
self-checking when preparing and administering medications.
CONCLUSIONS: Findings suggest no change in medication error rate, although ePA
encourages certain types of errors and mitigates others. There was a
statistically significant increase in documentation discrepancies which is likely
to be due to adoption of new working practices with ePA.
DOI: 10.1186/s12913-017-2462-2
PMCID: PMC5549345
PMID: 28793906 [Indexed for MEDLINE]
Hommel KA(1), Gray WN(2), Hente E(3), Loreaux K(3), Ittenbach RF(4), Maddux M(5),
Baldassano R(6), Sylvester F(7), Crandall W(8), Doarn C(9), Heyman MB(10), Keljo
D(11), Denson LA(4).
Author information:
(1)Cincinnati Children's Hospital Medical Center, United States; University of
Cincinnati College of Medicine, United States. Electronic address:
kevin.hommel@cchmc.org.
(2)Auburn University, United States.
(3)Cincinnati Children's Hospital Medical Center, United States.
(4)Cincinnati Children's Hospital Medical Center, United States; University of
Cincinnati College of Medicine, United States.
(5)Children's Mercy Hospitals and Clinics, United States; University of Missouri
Kansas City School of Medicine, United States.
(6)Children's Hospital of Philadelphia, United States; University of Pennsylvania
School of Medicine, United States.
(7)University of North Carolina, United States.
(8)Nationwide Children's Hospital, United States; Ohio State University College
of Medicine, United States.
(9)University of Cincinnati, United States.
(10)UCSF Benioff Children's Hospital, United States; University of California,
San Francisco, United States.
(11)Children's Hospital of Pittsburgh, United States; University of Pittsburgh
School of Medicine, United States.
DOI: 10.1016/j.cct.2015.05.013
PMCID: PMC4522393
PMID: 26003436 [Indexed for MEDLINE]
Author information:
(1)Department of Psychology, Royal Holloway, University of London, Egham, Surrey,
TW20 0EX, UK.
(2)Center for Children's Healthy Lifestyles and Nutrition, Children's Mercy
Kansas City, Kansas City, USA.
(3)Department of Pediatrics, University of Missouri - Kansas City, Kansas City,
USA.
(4)Health Services and Outcomes Research, Children's Mercy Kansas City, Kansas
City, USA.
(5)Schools of Medicine and Pharmacy, University of Missouri - Kansas City, Kansas
City, USA.
(6)Department of Psychology, Royal Holloway, University of London, Egham, Surrey,
TW20 0EX, UK. michael.evangeli@rhul.ac.uk.
DOI: 10.1007/s12529-018-09766-z
PMCID: PMC6440936
PMID: 30673961 [Indexed for MEDLINE]
Fishman J(1), Cohen G(2), Josephson C(3), Collier AM(4), Bharatham S(5), Zhang
Y(6), Wild I(7).
Author information:
(1)UCB Pharma, 1950 Lake Park Drive SE, Smyrna, GA 30080, USA. Electronic
address: jesse.fishman@ucb.com.
(2)UCB Pharma, 1950 Lake Park Drive SE, Smyrna, GA 30080, USA. Electronic
address: gregory.cohen@ucb.com.
(3)Department of Clinical Neurosciences, University of Calgary, Cummings School
of Medicine, Foothills Medical Center, 1403 29th St NW, Calgary, Alberta T2N 2T9,
Canada. Electronic address: cbjoseph@ucalgary.ca.
(4)St Mary's Hospital, 750 Wellington Ave, Grand Junction, CO 81501, USA.
Electronic address: marietxmd@gmail.com.
(5)UCB Pharma, 1950 Lake Park Drive SE, Smyrna, GA 30080, USA. Electronic
address: srikanth.bharatham@ucb.com.
(6)UCB Pharma, 1950 Lake Park Drive SE, Smyrna, GA 30080, USA. Electronic
address: ying.zhang5@ucb.com.
(7)UCB Pharma, 1950 Lake Park Drive SE, Smyrna, GA 30080, USA. Electronic
address: imane.wild@ucb.com.
OBJECTIVE: To investigate the impact of antiepileptic drug (AED) change and dose
titration on the emotional well-being of patients with epilepsy.
METHODS: Members of an online epilepsy community were invited to voluntarily
participate in an online survey. The cross-sectional anonymous survey consisted
of 31 multiple choice questions balanced in terms of variety and
positivity/negativity of emotions concerning participants' most recent AED
change. To substantiate survey results, spontaneous comments from
epilepsy-related online forums and social media websites that mentioned
participants' experiences with AED medication changes (termed passive listening
statements) were analyzed and categorized by theme.
RESULTS: All 345 survey participants (270 [78.3%] female; 172 [49.9%] were
26-45years old) self-reported an epilepsy/seizure diagnosis and were currently
taking seizure medication; 263 (76.2%) were taking ≥2 AEDs and 301 (87.2%) had ≥1
seizure in the previous 18months. All participants reported a medication change
within the previous 12months (dose increased [153 participants (44.3%)],
medication added [105 (30.4%)], dose decreased [49 (14.2%)], medication removed
[38 (11.0%)]). Improving seizure control (247 [71.6%]) and adverse events (109
[31.6%]) were the most common reasons for medication change. Primary emotions
most associated (≥10% of participants) with an AED regimen change were (before
medication change; during/after medication change) hopefulness (50 [14.5%]; 43
[12.5%]), uncertainty (50 [14.5%]; 69 [20.0%]), and anxiety (35 [10.1%]; 45
[13.0%]), and were largely due to concerns whether the change would work (212/345
[61.4%]; 180/345 [52.2%]). In the text analysis segment aimed at validating the
survey, 230 participants' passive listening statements about medication titration
were analyzed; additional seizure activity during dose titration (93 [40.4%]),
adverse events during titration (71 [30.9%]), higher medication dosages (33
[14.3%]), and drug costs (25 [10.9%]) were the most commonly noted concerns.
CONCLUSION: Although the emotional well-being of patients with epilepsy is
complex, our study results suggest that participants report their emotional
well-being as negatively affected by changes in AED regimen, with most patients
reporting uncertainty regarding the outcome of such a change. Future research is
warranted to explore approaches to alleviate patient concerns associated with AED
medication changes.
Copyright © 2017 Ellen Carey, UCB Brussels, Belgium. Published by Elsevier Inc.
All rights reserved.
DOI: 10.1016/j.yebeh.2017.01.032
PMID: 28222341 [Indexed for MEDLINE]
Singh JA(1), Herbey I(2), Bharat A(2), Dinnella JE(3), Pullman-Mooar S(3), Eisen
S(4), Ivankova N(2).
Author information:
(1)VA Medical Center and University of Alabama at Birmingham, and Mayo Clinic
College of Medicine, Rochester, Minnesota.
(2)University of Alabama at Birmingham.
(3)Philadelphia VA Medical Center and University of Pennsylvania, Philadelphia,
Pennsylvania.
(4)Washington University School of Medicine and St. Louis VA Medical Center, St.
Louis, Missouri.
DOI: 10.1002/acr.23202
PMID: 28118526 [Indexed for MEDLINE]
Basu S(1).
Author information:
(1)Department of Community Medicine, Maulana Azad Medical College, New Delhi,
India.
DOI: 10.4103/jfmpc.jfmpc_345_17
PMCID: PMC6069655
PMID: 30112326
Author information:
(1)Department of Population Health Sciences, Duke University, Durham, North
Carolina.
(2)411 West Chapel Hill St, Ste 600, Durham, NC 27701. Email:
Christiana.oshotse@duke.edu.
(3)Center for Health Services Research in Primary Care, Durham Veterans Affairs
Health Care System, Durham, North Carolina.
(4)Departments of Psychiatry and School of Nursing, Duke University, Durham,
North Carolina.
(5)Duke University Policy and Organizational Management Program, Durham, North
Carolina.
DOI: 10.5888/pcd15.180218
PMCID: PMC6198676
PMID: 30339772 [Indexed for MEDLINE]
1192. Medicine (Baltimore). 2019 Feb;98(6):e14291. doi:
10.1097/MD.0000000000014291.
Author information:
(1)Department of Medical Informatics, Faculty of Medicine.
(2)Neurogenic Inflammation Research Center.
(3)Targeted Drug Delivery Research Center.
(4)Kidney Transplantation Complications Research Center.
(5)Department of Nephrology, Faculty of Medicine.
(6)Complementary Medicine Research Center, Faculty of Traditional Medicine.
(7)Department of Emergency Medicine, Doctor Shariati Hospital.
(8)Pharmaceutical Research Center, Mashhad University of Medical Sciences,
Mashhad, Iran.
(9)Department of Medical Informatics, University of Amsterdam, Amsterdam, The
Netherlands.
DOI: 10.1097/MD.0000000000014291
PMCID: PMC6380874
PMID: 30732143 [Indexed for MEDLINE]
Author information:
(1)Department of Psychology, Child and Adolescent Psychology, Philipps-University
Marburg Marburg, Germany.
(2)Department of Psychology, Clinical Psychology, Philipps-University Marburg
Marburg, Germany.
DOI: 10.3389/fnhum.2014.00943
PMCID: PMC4244863
PMID: 25505396
1194. Rural Remote Health. 2019 May;19(2):5270. doi: 10.22605/RRH5270. Epub 2019
May
22.
Cui X(1), Zhou X(2), Ma LL(3), Sun TW(4), Bishop L(5), Gardiner FW(6), Wang L(7).
Author information:
(1)Department of Cardiology, Liaocheng People's Hospital, Liaocheng, Shandong,
252000, China cuixiaoning06@163.com.
(2)Department of Cardiology, Liaocheng People's Hospital, Liaocheng, Shandong,
252000, China lwayne450@gmail.com.
(3)Department of Cardiology, Liaocheng People's Hospital, Liaocheng, Shandong,
252000, China maldongchang@126.com.
(4)Department of General ICU, the First Affiliated Hospital of Zhengzhou
University, Henan Key Laboratory of Critical Care Medicine, Zhengzhou 450052,
Henan, China suntongwen@163.com.
(5)Royal Flying Doctor Service; and The Australian National University, Canberra,
ACT 2600, Australia lara.bishop@rfds.org.au.
(6)Royal Flying Doctor Service; and The Australian National University, Canberra,
ACT 2600, Australia gus_gardiner@hotmail.com.
(7)Department of Cardiology, Liaocheng People's Hospital, Liaocheng, Shandong,
252000, China; and School of Biomedical Sciences, Charles Sturt University, Wagga
Wagga, NSW 2650, Australia lwang@csu.edu.au.
DOI: 10.22605/RRH5270
PMID: 31113205
Orimo H(1), Sato M(2), Kimura S(2), Wada K(3), Chen X(3), Yoshida S(3), Crawford
B(3).
Author information:
(1)Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo,
Japan.
(2)Eli Lilly Japan K.K., Kobe, Japan.
(3)QuintilesIMS, Tokyo, Japan.
Objectives: This study aimed to identify factors associated with initiation and
adherence of osteoporosis medication from a patient perspective.
Methods: A web-based survey was developed based on health behavior theories.
Descriptive analyses were conducted for all survey items. Analyses in a
structural equation modeling framework were conducted to identify factors
associated with treatment initiation and adherence.
Results: Five hundred forty-five women completed the questionnaire. A majority
were currently receiving medications for osteoporosis (n = 376, 69.0%) and 25.0%
of these patients (n = 94) were considered adherent to their treatment. Knowledge
was strongly associated with osteoporosis treatment initiation (standard error
[SE], 0.58). Greater knowledge of disease was associated with increased
likelihood of initiating medication. Medication complexity (SE, 0.49) and
perceived susceptibility to fracture and loss of independence (SE, -0.37) were
also associated with initiation. Perceived barriers (SE, -0.85) such as
inconvenience, lack of efficacy and financial burden were observed to be the
greatest obstacle to adherence. The greater the perceived barriers, the less
likely patients were to adhere to medication. Patients' perception of
self-efficacy (SE, 0.37) also affected adherence. The greater the patient
perception of ability to independently manage their medication, the more likely
they were to adhere to the medication.
Conclusions: Different factors were found to be associated with initiation and
adherence of osteoporosis medication. Patient knowledge of their disease and the
perception of barriers were found to be the most influential. Empowering patients
with the knowledge to better understand their disease and decreasing the
perception of barriers through education initiatives may be effective in
improving patient outcomes.
DOI: 10.1016/j.afos.2017.10.002
PMCID: PMC6372844
PMID: 30775527
Emren SV(1), Şenöz O(2), Bilgin M(3), Beton O(4), Aslan A(5), Taşkin U(6),
Açiksari G(7), Asarcikli LD(3), Çakir H(8), Bekar L(9), Bolat İ(10), Yayla Ç(11),
Çelebi B(12), Dalgiç O(13), Çelik O(14), Şafak Ö(15), Akyel S(16), Güngör H(17),
Düzel B(18), Zoghi M(19).
Author information:
(1)1 Department of Cardiology, Afyonkarahisar State Hospital, Afyonkarahisar,
Turkey.
(2)2 Department of Cardiology, Artvin State Hospital, Artvin, Turkey.
(3)3 Department of Cardiology, Ankara Dışkapı Research and Education Hospital,
Ankara, Turkey.
(4)4 Department of Cardiology, Sivas Cumhuriyet University, Sivas, Turkey.
(5)5 Department of Cardiology, Dokuz Eylül University, Izmir, Turkey.
(6)6 Department of Cardiology, Akşehir State Hospital, Konya, Turkey.
(7)7 Department of Cardiology, Istanbul İstinye State Hospital, Istanbul, Turkey.
(8)8 Department of Cardiology, Darıca Farabi State Hospital, Kocaeli, Turkey.
(9)9 Department of Cardiology, Hitit University, Çorum, Turkey.
(10)10 Department of Cardiology, Fethiye State Hospital, Muğla, Turkey.
(11)11 Department of Cardiology, Ankara Yüksek İhtisas Research and Education
Hospital, Ankara, Turkey.
(12)12 Department of Cardiology, Silifke State Hospital, Mersin, Turkey.
(13)13 Department of Cardiology, Karşıyaka State Hospital, İzmir, Turkey.
(14)14 Department of Cardiology, School of Medicine, Hitit University, Çorum,
Turkey.
(15)15 Department of Cardiology, Burdur State Hospital, Burdur, Turkey.
(16)16 Department of Cardiology, Münif İslamoğlu State Hospital, Kastamonu,
Turkey.
(17)17 Department of Cardiology, Aydın University School of Medicine, Aydın,
Turkey.
(18)18 Department of Cardiology, Mersin State Hospital, Mersin, Turkey.
(19)19 Department of Cardiology, Ege University, Izmir, Turkey.
DOI: 10.1177/1076029617693940
PMCID: PMC6714660
PMID: 28301907 [Indexed for MEDLINE]
1197. Nicotine Tob Res. 2015 Jun;17(6):710-8. doi: 10.1093/ntr/ntu216. Epub 2014
Oct
21.
Klesges RC(1), Krukowski RA(2), Klosky JL(3), Liu W(4), Srivastava DK(4), Boyett
JM(4), Lanctot JQ(5), Hudson MM(6), Folsom C(5), Robison LL(5).
Author information:
(1)Department of Epidemiology and Cancer Control, St. Jude Children's Research
Hospital, Memphis, TN; Department of Preventive Medicine, University of Tennessee
Health Science Center, Memphis, TN; rklesges@uthsc.edu.
(2)Department of Preventive Medicine, University of Tennessee Health Science
Center, Memphis, TN;
(3)Department of Psychology, St. Jude Children's Research Hospital, Memphis, TN;
(4)Department of Biostatistics, St. Jude Children's Research Hospital, Memphis,
TN;
(5)Department of Epidemiology and Cancer Control, St. Jude Children's Research
Hospital, Memphis, TN;
(6)Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN.
© The Author 2014. Published by Oxford University Press on behalf of the Society
for Research on Nicotine and Tobacco. All rights reserved. For permissions,
please e-mail: journals.permissions@oup.com.
DOI: 10.1093/ntr/ntu216
PMCID: PMC4838048
PMID: 25335944 [Indexed for MEDLINE]
Author information:
(1)Pediatric Pulmonology, Michigan Medicine, Ann Arbor, Michigan.
(2)Department of Biostatistics, University of Michigan School of Public Health,
Ann Arbor, Michigan.
DOI: 10.1002/ppul.23950
PMID: 29457700 [Indexed for MEDLINE]
Access and adherence to medications for the primary and secondary prevention of
atherosclerotic cardiovascular disease in Singapore: a qualitative study.
Koh JJK(1), Cheng RX(2), Yap Y(2), Haldane V(1), Tan YG(2), Teo KWQ(2),
Srivastava A(1), Ong PS(2), Perel P(3), Legido-Quigley H(1)(3).
Author information:
(1)Saw Swee Hock School of Public Health, National University of Singapore,
Singapore, helena.legido-quigley@lshtm.ac.uk.
(2)Department of Pharmacy, National University of Singapore, Singapore.
(3)London School of Hygiene and Tropical Medicine, London, UK,
helena.legido-quigley@lshtm.ac.uk.
DOI: 10.2147/PPA.S176256
PMCID: PMC6255116
PMID: 30538432
Author information:
(1)Department of General Medicine Sengkang General Hospital 110 Sengkang East Way
Singapore 544886, Singapore.
(2)National University of Singapore, Singapore.
(3)Singapore General Hospital, Singapore.
Background: We evaluated the outcome for fasting Muslims with diabetes prepared
with pre-Ramadan optimization through education and medication adjustment,
tele-support and intervention up to post-Ramadan.
Methods: Muslims with diabetes planning to fast were recruited into a focused
diabetes program for Ramadan fasting.It consisted of (a) a pre-Ramadan assessment
and test fasting to optimize glycemic control, (b) education on diabetes
management during fasting, (c) tele-monitoring from pre-Ramadan and (d) a
post-Ramadan review. Their metabolic profiles and diaries for meals, activities
and glucose monitoring were evaluated.
Results: Twenty-nine participants were enrolled, with mean age 58.4 ± 9.2 years,
75.9% female, 79.3% Malays and 93.1% type 2 diabetes. A total of 92% needed
medication adjustment and 93% fasted for at least 14 days. Glycated hemoglobin
(HbA1c) and weight decreased from 8.8 ± 1.8% (72.7 mmol/mol) pre-Ramadan to 8.5 ±
1.7% (69.4 mmol/mol) post-Ramadan and 76.6 ± 20.3 kg pre-Ramadan to 75.9 ± 21.3
kg post-Ramadan, respectively. There were decreased complications of hypoglycemia
from 13.8% to 10.3% and several-fold improvement in hyperglycemia from 31.0% to
3.5% during Ramadan fasting when compared with pre-Ramadan.
Conclusions: Muslims with diabetes were able to self-manage when fasting using
tele-monitoring support and intervention, with decreased complications during
Ramadan compared with pre-Ramadan.
DOI: 10.1177/2042018818781669
PMCID: PMC6116763
PMID: 30181849
Author information:
(1)Department of Psychology, Simon Fraser University, Burnaby, BC, Canada.
(2)Faculty of Medicine, The University of British Columbia, Vancouver, Canada.
Brittain K(1)(2), Asafu-Agyei NA(3)(4), Hoare J(5), Bekker LG(6), Rabie H(7),
Nuttall J(3), Roux P(3), Stein DJ(5), Zar HJ(3)(4), Myer L(8)(9).
Author information:
(1)Division of Epidemiology & Biostatistics, School of Public Health & Family
Medicine, University of Cape Town, Cape Town, South Africa.
kirsty.brittain@uct.ac.za.
(2)Centre for Infectious Disease Epidemiology & Research, School of Public Health
& Family Medicine, University of Cape Town, Cape Town, South Africa.
kirsty.brittain@uct.ac.za.
(3)Department of Paediatrics & Child Health, University of Cape Town, Cape Town,
South Africa.
(4)Medical Research Council Unit on Child & Adolescent Health, Cape Town, South
Africa.
(5)Department of Psychiatry & Mental Health, University of Cape Town, Cape Town,
South Africa.
(6)Desmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular
Medicine, University of Cape Town, Cape Town, South Africa.
(7)Department of Paediatrics & Child Health, Tygerberg Academic Hospital &
Stellenbosch University, Cape Town, South Africa.
(8)Division of Epidemiology & Biostatistics, School of Public Health & Family
Medicine, University of Cape Town, Cape Town, South Africa.
(9)Centre for Infectious Disease Epidemiology & Research, School of Public Health
& Family Medicine, University of Cape Town, Cape Town, South Africa.
Author information:
(1)Department of Clinical Sciences in Malmö, Lund University , Malmö , Sweden.
DOI: 10.3109/02813432.2014.972062
PMCID: PMC4278387
PMID: 25347723 [Indexed for MEDLINE]
Author information:
(1)Clinical Pharmacy Group, Division of Pharmacology and Pharmacotherapy, Faculty
of Pharmacy, University of Helsinki, Finland.
(2)General Practice, School of Medicine, University of Western Australia,
Crawley, Western Australia, Australia.
(3)Department of General Practice and Primary Health Care, Helsinki University
Central Hospital, University of Helsinki, Finland.
BACKGROUND: General practitioners (GPs) manage the drug therapies of people with
chronic diseases, and poor adherence to medication remains a major challenge.
OBJECTIVE: This qualitative study examined GPs' insights into non-adherence and
ways of overcoming this problem.
METHODS: We ran four focus groups comprising 16 GPs at the Kirkkonummi Health
Centre (Southern Finland). Interviews were audiotaped, transcribed verbatim and
analysed by inductive content analysis.
MAIN RESULTS: The two main themes in the discussions with the GPs were
non-adherence in the care of chronic disease and increased need for medicine
information. The medication management challenges identified were related to:
patient-specific factors, the healthcare system, characteristics of drug
therapies and the function and role of healthcare professionals as a team. To
improve the situation, the GPs offered a number of solutions: improved
coordination of care, better patient education and IT systems as well as enhanced
interprofessional involvement in the follow-up of patients.
DISCUSSION AND CONCLUSIONS: With an ageing population, the GPs were increasingly
confronted with non-adherence in the care of chronic diseases. They had mostly a
positive attitude towards organising care in a more interprofessional manner. To
support medication adherence and self-management, the GPs appreciated
pharmacists' assistance especially with patients with polypharmacy and chronic
diseases.
© Article author(s) (or their employer(s) unless otherwise stated in the text of
the article) 2018. All rights reserved. No commercial use is permitted unless
otherwise expressly granted.
DOI: 10.1136/bmjopen-2016-015332
PMCID: PMC5786122
PMID: 29362241 [Indexed for MEDLINE]
Author information:
(1)PhD Student, Department of Biomedicine and Prevention, University of Rome Tor
Vergata, Italy - Department of Public Health and Infectious Diseases, Sapienza
University of Rome, Italy.
(2)University Campus Bio-Medico, Rome, Italy.
(3)Department of Public Health and Infectious Diseases, Sapienza University of
Rome, Italy.
AIM: Medication errors are dangerous for the patients in an intensive care unit
(ICU). Little is known about knowledge, attitudes and professional behaviour of
nurses towards prevention of errors and clinical risk management can reduce
errors during the preparation and administration phases of intravenous drugs. In
this study we have evaluated the reliability and validity of the questionnaire to
examine knowledge, attitudes and professional behaviour of ICU nurses.
METHODS: Reliability analysis was tested and content validity evaluated using
Cronbach's alpha to check internal consistency with the intention to obtain no
misunderstanding with the results. The questionnaire composed of seven sections
for a total of 36 items, was administrated among ICU nurses working in a
university hospital in Rome, Italy. Data were collected in October 2015.
Statistical analysis was performed with the statistical software for Windows
SPSS, version 22.0.
RESULTS: The questionnaire was administered to 30 ICU nurses' in anonymous,
voluntary and self-administered form with close-ended type of questions, except
for the socio-demographic characteristics. The highest value of Cronbach's alpha
resulted on 19 items (alpha= 0,776) meaning that the questionnaire has a
satisfactory internal validity. The study highlights that nurses (80%) are aware
that appropriate knowledge on the calculation of medication's dose is essential
to reduce medication errors during the phase of drugs'preparation.
CONCLUSION: This study demonstrated that a short version of the questionnaire has
very good reliability properties in the study and this needs to be taken into
account for future studies.
DOI: 10.7416/ai.2016.2090
PMID: 27071322 [Indexed for MEDLINE]
Author information:
(1)Department of Clinical Nutrition, Hikone Municipal Hospital, Hikone, Shiga,
Japan.
(2)Department of Diabetes and Metabolism, Hikone Municipal Hospital, Hikone,
Shiga, Japan.
DOI: 10.1111/jdi.12571
PMCID: PMC5334309
PMID: 27565735 [Indexed for MEDLINE]
Given BA(1), Given CW(2), Sikorskii A(3), Vachon E(1), Banik A(4).
Author information:
(1)College of Nursing, Michigan State University, East Lansing, MI, USA.
(2)Department of Family Medicine, College of Human Medicine, Michigan State
University, East Lansing, MI, USA.
(3)College of Nursing, University of Arizona, Tucson, AZ, USA.
(4)Department of Statistics and Probability, College of Natural Science, Michigan
State University, East Lansing, MI, USA.
OBJECTIVE: With the changes in healthcare, patients with cancer now have to
assume greater responsibility for their own care. Oral cancer medications with
complex regimens are now a part of cancer treatment. Patients have to manage
these along with the management of medications for their other chronic illnesses.
This results in medication burden as patients assume the self-management.
METHODS: This paper describes the treatment burdens that patients endured in a
randomized, clinical trial examining adherence for patients on oral cancer
medications. There were four categories of oral agents reported. Most of the
diagnoses of the patients were solid tumors with breast, colorectal, renal, and
gastrointestinal.
RESULTS: Patients had 1-4 pills/day for oral cancer medications as well as a
number for comorbidity conditions (>3), for which they also took medications
(10-11). In addition, patients had 3.7-5.9 symptoms and side effects. Patients on
all categories except those on sex hormones had 49%-57% drug interruptions
necessitating further medication burden.
CONCLUSIONS: This study points out that patients taking oral agents have multiple
medications for cancer and other comorbid conditions. The number of pills, times
per day, and interruptions adds to the medication burden that patients'
experience. Further study is needed to determine strategies to assist the
patients on oral cancer medications to reduce their medication burden.
DOI: 10.4103/apjon.apjon_7_17
PMCID: PMC5559936
PMID: 28966954
1208. J Investig Allergol Clin Immunol. 2019 Feb 11:0. doi: 10.18176/jiaci.0387.
[Epub
ahead of print]
Urrutia I(1), Delgado J(2), Domínguez-Ortega J(3), Mascarós E(4), Pérez M(5),
Resler G(5), Plaza V(6); on behalf on the MISTRAL Investigators Group.
Author information:
(1)Respiratory Department, Galdakao Hospital, OSI Barrualde-Galdakao, Biscay,
Spain.
(2)Allergy Department, Hospital Virgen Macarena, Sevilla, Spain.
(3)Department of Allergy, Healthcare Research Institute IdiPAZ, CIBER de
Enfermedades Respiratorias, CIBERES, Hospital Universitario La Paz, Madrid,
Spain.
(4)Medicina de Familia y Comunitaria, Centro de Salud Fuente de San Luis,
Valencia, Spain, Spain.
(5)Medical Department AstraZeneca. Barcelona. Spain.
(6)Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau,
Institut d´Investigació Biomédica Sant Pau (IIB Sant Pau), Barcelona, Spain.
BACKGROUND AND OBJECTIVE: Our aim was to evaluate the relationship between asthma
clinical factors and use of relief medication.
METHODS: This was an observational cross-sectional study conducted in Spain. The
study recruited patients ≥ 12 years of age diagnosed with persistent asthma
according to the GINA criteria and receiving maintenance treatment for at least
12 months. Use of relief medication was dichotomized: low use of rescue
medication (LURM) (≤ twice/week) or high use of rescue medication (HURM) (≥ three
times/week). A variety of clinical variables and patient reported outcomes (PROs)
such as the Asthma Control Questionnaire-5 (ACQ-5) and Test of Adherence to
Inhalers (TAI) were recorded.
RESULTS: A total of 406 patients were recruited, mean (SD) age 44.3(17.9) years
and 64% women. In 76.1% rescue medication was used ≤ twice/week. Bivariate
analysis showed HURM was related to smoking habit, unscheduled emergency room
visits, hospital admissions, increased inhaled corticosteroid doses, therapeutic
upgrading and night awakenings in the last four weeks (p<0.001). The multivariate
analysis showed a higher risk of using relief medication in smokers and former
smokers, when the number of night awakenings increased, in cases of
self-perception of partially controlled or uncontrolled asthma, or when asthma is
uncontrolled according to ACQ-5.
CONCLUSIONS: Our study identifies the potential of using abuse of rescue
medication in the last week as an alarm signal for disease parameters such as
exacerbations, poor asthma control and disease severity.
DOI: 10.18176/jiaci.0387
PMID: 30741637
Conn VS(1), Ruppar TM, Chan KC, Dunbar-Jacob J, Pepper GA, De Geest S.
Author information:
(1)University of Missouri , Columbia, MO , USA.
OBJECTIVE: Inadequate medication adherence is a widespread problem that
contributes to increased chronic disease complications and health care
expenditures. Packaging interventions using pill boxes and blister packs have
been widely recommended to address the medication adherence issue. This
meta-analysis review determined the overall effect of packaging interventions on
medication adherence and health outcomes. In addition, we tested whether effects
vary depending on intervention, sample, and design characteristics.
RESEARCH DESIGN AND METHODS: Extensive literature search strategies included
examination of 13 computerized databases and 19 research registries, hand
searches of 57 journals, and author and ancestry searches. Eligible studies
included either pill boxes or blister packaging interventions to increase
medication adherence. Primary study characteristics and outcomes were reliably
coded. Random-effects analyses were used to calculate overall effect sizes and
conduct moderator analyses.
RESULTS: Data were synthesized across 22,858 subjects from 52 reports. The
overall mean weighted standardized difference effect size for two-group
comparisons was 0.593 (favoring treatment over control), which is consistent with
the mean of 71% adherence for treatment subjects compared to 63% among control
subjects. We found using moderator analyses that interventions were most
effective when they used blister packs and were delivered in pharmacies, while
interventions were less effective when studies included older subjects and those
with cognitive impairment. Methodological moderator analyses revealed
significantly larger effect sizes in studies reporting continuous data outcomes
instead of dichotomous results and in studies using pharmacy refill medication
adherence measures compared with studies with self-report measures.
CONCLUSIONS: Overall, meta-analysis findings support the use of packaging
interventions to effectively increase medication adherence. Limitations of the
study include the exclusion of packaging interventions other than pill boxes and
blister packs, evidence of publication bias, and primary study sparse reporting
of health outcomes and potentially interesting moderating variables such as the
number of prescribed medications.
DOI: 10.1185/03007995.2014.978939
PMCID: PMC4562676
PMID: 25333709 [Indexed for MEDLINE]
1210. Bipolar Disord. 2015 Feb;17(1):106-12. doi: 10.1111/bdi.12226. Epub 2014 Jun
26.
Author information:
(1)Mandel School of Applied Social Sciences, Case Western Reserve University,
Cleveland, OH, USA.
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
DOI: 10.1111/bdi.12226
PMCID: PMC4277504
PMID: 24974829 [Indexed for MEDLINE]
Author information:
(1)School of Nursing, Western Carolina University, Cullowhee, NC, United States.
(2)College of Nursing, Medical University of South Carolina, Charleston, SC,
United States.
(#)Contributed equally
DOI: 10.2196/diabetes.8030
PMCID: PMC6238839
PMID: 30291093
Alencar RA(1), Parenti ABH(1), Lopes CC(1), Ramos FT(1), Ciosak SI(2).
Author information:
(1)Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu,
SP, Brazil.
(2)Universidade de São Paulo, Escola de Enfermagem, São Paulo, SP, Brazil.
DOI: 10.1590/1518-8345.2746.3112
PMCID: PMC6432987
PMID: 30916226 [Indexed for MEDLINE]
Author information:
(1)Pharmaceutical Care Research Group, Department of Pharmaceutical Sciences,
University of Basel Basel, Switzerland.
BACKGROUND: Multidrug punch cards are frame cards with 28 plastic cavities filled
with a patient's oral solid medication. They are used in primary care to
facilitate medication management and to enhance adherence. Main criticism
concerned handling difficulties and fading knowledge about medication of patients
using them. This study aimed at exploring daily use, preferences, and adherence
of primary care patients using multidrug punch cards.
METHODS: Community pharmacies in Switzerland recruited primary care patients
using multidrug punch cards. A mixed methods approach was applied with
quantitative interviews performed by telephone and qualitative interviews
face-to-face.
RESULTS: Of 149 eligible patients from 21 community pharmacies, 22 participated
2011 in the quantitative and 11 participated 2013/14 in the qualitative
interview. Patients were very satisfied with the multidrug punch cards and stated
increased medication safety. All considered adherence as very important.
Self-reported adherence was 10 (median) on a visual analog scale (0 = no intake,
10 = perfect adherence). The absence of package inserts and predefined handling
difficulties e.g., tablets spiking at removal were not perceived as problems.
CONCLUSIONS: Patients are satisfied with the multidrug punch cards, feel safe,
mostly have no handling problems and adhere to their treatment. Trust in
health-care professionals and patients' experiences emerged as key variables for
initiating multidrug punch card use and for medication adherence. This mixed
methods study invalidates previous concerns about disadvantages of multidrug
punch cards. Health-care professionals should actively recommend them for primary
care patients with polypharmacy and poor adherence.
DOI: 10.3389/fphar.2014.00220
PMCID: PMC4181287
PMID: 25324777
Nikulina V(1), Guarino H, Acosta MC, Marsch LA, Syckes C, Moore SK, Portenoy RK,
Cruciani RA, Turk DC, Rosenblum A.
Author information:
(1)aDepartment of Psychology, Queens College, CUNY, Flushing, NY, USA bNational
Development and Research Institutes, Inc, New York, NY, USA cDartmouth Center for
Technology and Behavioral Health, Lebanon, NH, USA dMJHS Institute for Innovation
in Palliative Care, New York, NY, USA eCapital Health, Pennington, NJ, USA
fUniversity of Washington, Seattle, WA, USA.
During long-term opioid therapy for chronic noncancer pain, monitoring medication
adherence of patients with a history of aberrant opioid medication-taking
behaviors (AMTB) is an essential practice. There is limited research, however,
into the concordance among existing monitoring tools of self-report, physician
report, and biofluid screening. This study examined associations among patient
and provider assessments of AMTB and urine drug screening using data from a
randomized trial of a cognitive-behavioral intervention designed to improve
medication adherence and pain-related outcomes among 110 opioid-treated patients
with chronic pain who screened positive for AMTB and were enrolled in a pain
program. Providers completed the Aberrant Behavior Checklist (ABC) and patients
completed the Current Opioid Misuse Measure (COMM) and the Chemical Coping
Inventory (CCI). In multivariate analyses, ABC scores were compared with COMM and
CCI scores, while controlling for demographics and established risk factors for
AMTB, such as pain severity. Based on clinical cutoffs, 84% of patients reported
clinically significant levels of AMTB and providers rated 36% of patients at
elevated levels. Provider reports of AMTB were not correlated with COMM or CCI
scores. However, the ABC ratings of experienced providers (nurse
practitioners/attending physicians) were higher than those of less experienced
providers (fellows) and were correlated with CCI scores and risk factors for
AMTB. Associations between patient- and provider-reported AMTB and urine drug
screening results were low and largely nonsignificant. In conclusion, concordance
between patient and provider reports of AMTB among patients with chronic pain
prescribed opioid medication varied by provider level of training.
DOI: 10.1097/j.pain.0000000000000583
PMCID: PMC4949142
PMID: 27082008 [Indexed for MEDLINE]
Serper M(1), Patzer RE, Reese PP, Przytula K, Koval R, Ladner DP, Levitsky J,
Abecassis MM, Wolf MS.
Author information:
(1)Division of Gastroenterology and Hepatology.
DOI: 10.1002/lt.24023
PMCID: PMC5831120
PMID: 25312406 [Indexed for MEDLINE]
Author information:
(1)Institute of Health and Care Sciences, University of Gothenburg, Gothenburg,
Sweden.
(2)Department of Medical and Health Sciences, Linköping University, Linköping,
Sweden.
(3)Centre for Person-Centred Care (GPCC), University of Gothenburg, Gothenburg,
Sweden.
(4)Department of Applied Information Technology, University of Gothenburg,
Gothenburg, Sweden.
DOI: 10.2147/PPA.S157658
PMCID: PMC5885974
PMID: 29643739
Author information:
(1)Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental
Health Disorders, Innlandet Hospital Trust, P.O. Box 104, 2381 Brumunddal, Hamar,
Norway. j.g.bramness@medisin.uio.no.
(2)Institute of Clinical Medicine, University of Tromsø - The Arctic University
of Norway, Tromsø, Norway. j.g.bramness@medisin.uio.no.
(3)Department of Psychology, University of Oslo, Oslo, Norway.
(4)Norwegian Social Research, OsloMet - Oslo Metropolitan University, Oslo,
Norway.
BACKGROUND: A small number of studies have shown that the use of cannabis
increases the risk of bronchial asthma. There is, however, a paucity of
longitudinal studies which are able to control for known risk factors of
bronchial asthma.
METHODS: Survey data from a population-based longitudinal study encompassing 2602
young adults followed for 13 years were coupled with individual prescription data
on asthma medication (β2-adrenergic receptor agonists and glucocorticoids for
inhalation) from the Norwegian national prescription database, which covers the
entire Norwegian population. Current cannabis use, gender, age, years of
education, body mass index (BMI; kg/m2) and current smoking were measured.
RESULTS: Prescription of asthma medication was associated with female gender,
self-reported earlier asthma and allergies, daily tobacco smoking and current
cannabis use. In a model adjusting for gender, age, years of education, BMI,
earlier self-reported asthma and allergies and current tobacco smoking the odds
ratio for a current cannabis user to fill prescriptions for asthma medication was
1.71 (95% CI: 1.06-2.77; p = 0.028).
CONCLUSIONS: This suggests that cannabis is a risk factor for bronchial asthma or
use of asthma medication even when known risk factors are taken into
consideration. Intake of cannabis through smoking should be avoided in persons at
risk.
DOI: 10.1186/s12890-019-0814-x
PMCID: PMC6390535
PMID: 30808319 [Indexed for MEDLINE]
Zwikker HE(1), van Dulmen S(2), den Broeder AA(1), van den Bemt BJ(3), van den
Ende CH(1).
Author information:
(1)Department of Rheumatology, Sint Maartenskliniek, Nijmegen, the Netherlands ;
Department of Pharmacy, Sint Maartenskliniek, Nijmegen, the Netherlands.
(2)Department of Primary and Community Care, Radboud University Medical Centre,
Nijmegen, the Netherlands ; NIVEL (Netherlands Institute for Health Services
Research), Utrecht, the Netherlands ; Department of Health Science, Buskerud and
Vestfold University College, Drammen, Norway.
(3)Department of Rheumatology, Sint Maartenskliniek, Nijmegen, the Netherlands ;
Department of Pharmacy, Sint Maartenskliniek, Nijmegen, the Netherlands ;
Department of Pharmacy, Radboud University Medical Centre, Nijmegen, the
Netherlands.
DOI: 10.2147/PPA.S66849
PMCID: PMC4270192
PMID: 25525340
Daily Communal Coping in Couples With Type 2 Diabetes: Links to Mood and
Self-Care.
Zajdel M(1), Helgeson VS(1), Seltman HJ(1), Korytkowski MT(2), Hausmann LRM(3).
Author information:
(1)Carnegie Mellon University, Pittsburgh, PA.
(2)University of Pittsburgh Medical Center, Pittsburgh, PA.
(3)VA Pittsburgh Healthcare System, Pittsburgh, PA.
DOI: 10.1093/abm/kax047
PMCID: PMC5855113 [Available on 2019-02-17]
PMID: 29538665
Suzuki T(1), Shiga T(2), Omori H(3), Tatsumi F(4), Nishimura K(5), Hagiwara N(1).
Author information:
(1)Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
(2)Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
Electronic address: mshiga@hij.twmu.ac.jp.
(3)Department of Medicine, Tokyo Women's Medical University Medical Center East,
Tokyo, Japan.
(4)Department of Cardiology, Tokyo Women's Medical University Aoyama Hospital,
Tokyo, Japan.
(5)Department of Psychiatry, Tokyo Women's Medical University, Tokyo, Japan.
DOI: 10.1016/j.jjcc.2016.11.009
PMID: 28007412 [Indexed for MEDLINE]
1221. Health Serv Res Manag Epidemiol. 2015 Jun 4;2:2333392815589094. doi:
10.1177/2333392815589094. eCollection 2015 Jan-Dec.
Health Literacy and Medication Adherence Among Patients Treated in a Free Health
Clinic: A Pilot Study.
Sawkin MT(1)(2), Deppe SJ(3), Thelen J(4)(5), Stoner SC(1), Dietz CA(2), Rasu
RS(5).
Author information:
(1)Department of Pharmacy Practice and Administration, University of Missouri -
Kansas City School of Pharmacy, Kansas City, Missouri, USA.
(2)Kansas City CARE Clinic, formerly known as Kansas City Free Health Clinic,
Kansas City, Missouri, USA.
(3)Medical Science Liaison, Medical Affairs - Virology, Janssen Pharmaceutical of
Johnson & Johnson, Kansas City, Missouri, USA.
(4)Department of Psychology, University of Missouri - Kansas City, Kansas City,
Missouri, USA.
(5)Department of Pharmacy Practice, School of Pharmacy, University of Kansas,
Lawrence, Kansas, USA.
DOI: 10.1177/2333392815589094
PMCID: PMC5266426
PMID: 28462257
1222. Med Princ Pract. 2017;26(1):35-40. doi: 10.1159/000450644. Epub 2016 Sep 7.
Author information:
(1)Public Authority for Applied Education and Training, Safat, Kuwait.
DOI: 10.1159/000450644
PMCID: PMC5588393
PMID: 27607329 [Indexed for MEDLINE]
Conn VS(1), Ruppar TM(2), Chase JA(3), Enriquez M(4), Cooper PS(5).
Author information:
(1)School of Nursing, University of Missouri, S317 Sinclair Building, Columbia,
MO, 65211, USA. conn@missouri.edu.
(2)School of Nursing, University of Missouri, S423 Sinclair Building, Columbia,
MO, 65211, USA.
(3)School of Nursing, University of Missouri, S343 Sinclair Building, Columbia,
MO, 65211, USA.
(4)School of Nursing, University of Missouri, S327 Sinclair Building, Columbia,
MO, 65211, USA.
(5)School of Nursing, University of Missouri, S318 Sinclair Building, Columbia,
MO, 65211, USA.
DOI: 10.1007/s11906-015-0606-5
PMCID: PMC5662945
PMID: 26560139 [Indexed for MEDLINE]
Why do some people with type 2 diabetes who are using insulin have poor glycaemic
control? A qualitative study.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://group.bmj.com/group/rights-licensing/permissions.
DOI: 10.1136/bmjopen-2014-006407
PMCID: PMC4316456
PMID: 25633285 [Indexed for MEDLINE]
Author information:
(1)School of Nursing, China Medical University, Shenyang City, Liaoning Province,
People's Republic of China.
(2)Department of Community-Public Health, Johns Hopkins University School of
Nursing, Baltimore, MD, USA.
(3)Endocrinology Department, Peking Union Medical College Hospital, Beijing,
People's Republic of China.
(4)Department of Community-Public Health, Johns Hopkins University School of
Nursing, Baltimore, MD, USA hhan3@jhu.edu.
DOI: 10.1177/0163278715588927
PMCID: PMC4792777
PMID: 26130465 [Indexed for MEDLINE]
Umeukeje EM(1), Merighi JR(2), Browne T(3), Victoroff JN(4), Umanath K(5), Lewis
JB(1), Ikizler TA(1), Wallston KA(6), Cavanaugh K(7).
Author information:
(1)Division of Nephrology and Hypertension, Vanderbilt University, Nashville,
Tennessee; Vanderbilt Center for Kidney Disease, Nashville, Tennessee.
(2)School of Social Work, University of Minnesota, Saint Paul, Minnesota.
(3)College of Social Work, University of South Carolina, Columbia, South
Carolina.
(4)School of Medicine, University of Washington, Seattle, Washington.
(5)Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit,
Michigan.
(6)Vanderbilt University School of Nursing, Nashville, Tennessee.
(7)Division of Nephrology and Hypertension, Vanderbilt University, Nashville,
Tennessee; Vanderbilt Center for Kidney Disease, Nashville, Tennessee. Electronic
address: kerri.cavanaugh@vanderbilt.edu.
Erratum in
J Ren Nutr. 2019 Aug 13;:.
DOI: 10.1053/j.jrn.2015.03.001
PMCID: PMC4546917
PMID: 25912398 [Indexed for MEDLINE]
1227. Pediatr Blood Cancer. 2017 Dec;64(12). doi: 10.1002/pbc.26689. Epub 2017 Jun
23.
Green NS(1), Manwani D(2), Matos S(3), Hicks A(3), Soto L(4), Castillo Y(4),
Ireland K(2), Stennett Y(4), Findley S(5), Jia H(6), Smaldone A(6).
Author information:
(1)Department of Pediatrics, Columbia University Medical Center, New York, New
York.
(2)Department of Pediatrics, Albert Einstein College of Medicine, New York, New
York.
(3)Community Health Worker Network of New York City, New York, New York.
(4)Community League of the Heights, New York, New York.
(5)Mailman School of Public Health, Columbia University, New York, New York.
(6)Columbia University School of Nursing, New York, New York.
INTRODUCTION: The main therapeutic intervention for sickle cell disease (SCD) is
hydroxyurea (HU). The effect of HU is largely through dose-dependent induction of
fetal hemoglobin (HbF). Poor HU adherence is common among adolescents.
METHODS: Our 6-month, two-site pilot intervention trial, "HABIT," was led by
culturally aligned community health workers (CHWs). CHWs performed support
primarily through home visits, augmented by tailored text message reminders.
Dyads of youth with SCD ages 10-18 years and a parent were enrolled. A customized
HbF biomarker, the percentage decrease from each patients' highest historical
HU-induced HbF, "Personal best," was used to qualify for enrollment and assess HU
adherence. Two primary outcomes were as follows: (1) intervention feasibility and
acceptability and (2) HU adherence measured in three ways: monthly percentage
improvement toward HbF Personal best, proportion of days covered (PDC) by HU, and
self-report.
RESULTS: Twenty-eight dyads were enrolled, of which 89% were retained.
Feasibility and acceptability were excellent. Controlling for group assignment
and month of intervention, the intervention group improved percentage decrease
from Personal best by 2.3% per month during months 0-4 (P = 0.30), with similar
improvement in adherence demonstrated using pharmacy records. Self-reported
adherence did not correlate. Dyads viewed CHWs as supportive for learning about
SCD and HU, living with SCD and making progress in coordinated self-management
responsibility to support a daily HU habit. Most parents and youth appreciated
text message HU reminders.
CONCLUSIONS: The HABIT pilot intervention demonstrated feasibility and
acceptability with promising effect toward improved medication adherence. Testing
in a larger multisite intervention trial is warranted.
DOI: 10.1002/pbc.26689
PMCID: PMC6538388
PMID: 28643377 [Indexed for MEDLINE]
Amblee A(1).
Author information:
(1)Department of Internal Medicine, Division of Endocrinology, John Stroger
Hospital of Cook County, Chicago, IL, USA; Rush University Medical Center,
Chicago, IL, USA.
DOI: 10.2147/PPA.S82866
PMCID: PMC4898439
PMID: 27330280
Asthma Home Management in the Inner-City: What can the Children Teach us?
Bellin MH, Newsome A, Land C, Kub J, Mudd SS, Bollinger ME, Butz AM.
DOI: 10.1016/j.pedhc.2016.11.002
PMCID: PMC6407130
PMID: 27955875 [Indexed for MEDLINE]
Author information:
(1)Swiss Tropical and Public Health Institute, Basel, Switzerland; University of
Basel, Switzerland.
(2)Service of Infectious Diseases, Lausanne University Hospital, Switzerland.
DOI: 10.4414/smw.2014.14016
PMID: 25275364 [Indexed for MEDLINE]
Author information:
(1)Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann
Arbor, MI, USA, jpiette@umich.edu.
BACKGROUND: Mobile health (mHealth) services cannot easily adapt to users' unique
needs.
PURPOSE: We used simulations of text messaging (SMS) for improving medication
adherence to demonstrate benefits of interventions using reinforcement learning
(RL).
METHODS: We used Monte Carlo simulations to estimate the relative impact of an
intervention using RL to adapt SMS adherence support messages in order to more
effectively address each non-adherent patient's adherence barriers, e.g.,
forgetfulness versus side effect concerns. SMS messages were assumed to improve
adherence only when they matched the barriers for that patient. Baseline
adherence and the impact of matching messages were estimated from literature
review. RL-SMS was compared in common scenarios to simple reminders, random
messages, and standard tailoring.
RESULTS: RL could produce a 5-14% absolute improvement in adherence compared to
current approaches. When adherence barriers are not accurately reported, RL can
recognize which barriers are relevant for which patients. When barriers change,
RL can adjust message targeting. RL can detect when messages are sent too
frequently causing burnout.
CONCLUSIONS: RL systems could make mHealth services more effective.
DOI: 10.1007/s12160-014-9634-7
PMCID: PMC4335096
PMID: 25082177 [Indexed for MEDLINE]
Treatment outcomes and factors affecting unsuccessful outcome among new pulmonary
smear positive and negative tuberculosis patients in Anqing, China: a
retrospective study.
Wen Y(1), Zhang Z(2), Li X(2), Xia D(3), Ma J(3), Dong Y(3), Zhang X(3).
Author information:
(1)School of Laboratory Medicine, Wannan Medical College, 22 West Wenchang Road,
Wuhu, Anhui Province, 241002, People's Republic of China. wyf@wnmc.edu.cn.
(2)Tuberculosis Prevention and Control Department, Anqing Center for Disease
Control and Prevention, Anqing City, Anhui Province, 246003, People's Republic of
China.
(3)School of Laboratory Medicine, Wannan Medical College, 22 West Wenchang Road,
Wuhu, Anhui Province, 241002, People's Republic of China.
DOI: 10.1186/s12879-018-3019-7
PMCID: PMC5836329
PMID: 29506480 [Indexed for MEDLINE]
A Systematic Review of Health Literacy Interventions for People Living with HIV.
Author information:
(1)Frances Payne Bolton School of Nursing, Case Western Reserve University, 2120
Cornell Road, Cleveland, OH, USA. jdp118@case.edu.
(2)School of Nursing, Rutgers University, Newark, NJ, USA.
(3)Frances Payne Bolton School of Nursing, Case Western Reserve University, 2120
Cornell Road, Cleveland, OH, USA.
DOI: 10.1007/s10461-016-1329-6
PMCID: PMC5484044
PMID: 26864691 [Indexed for MEDLINE]
Author information:
(1)School of Pharmacy, Curtin University, Perth, Western Australia, Australia.
(2)Faculty of Medicine, Pharmacy Department, University of Prishtina, Prishtina,
Kosovo.
DOI: 10.1371/journal.pone.0154992
PMCID: PMC4865180
PMID: 27170997 [Indexed for MEDLINE]
Author information:
(1)Manchester University College of Pharmacy, Natural and Health Sciences, Fort
Wayne, Indiana.
(2)Dupont Hospital, Fort Wayne, Indiana.
Objective. To describe the redesigned assessment plan for a patient safety and
informatics course and assess student pharmacist performance and perceptions.
Methods. The final examination of a patient safety course was redesigned from
traditional multiple choice and short answer to team-based, open-ended, and
case-based. Faculty for each class session developed higher level activities,
focused on developing key skills or attitudes deemed essential for practice, for
a progressive patient case consisting of nine activities. Student performance and
perceptions were analyzed with pre- and post-surveys using 5-point scales.
Results. Mean performance on the examination was 93.6%; median scores for each
assessed course outcome ranged from 90% to 100%. Eighty-five percent of students
completed both surveys. Confidence performing skills and demonstrating attitudes
improved for each item on post-survey compared with pre-survey. Eighty-one
percent of students indicated the experience of taking the examination was
beneficial for their professional development. Conclusion. A team, case-based
examination was associated with high student performance and improved
self-confidence in performing medication safety-related skills.
DOI: 10.5688/ajpe816117
PMCID: PMC5607727
PMID: 28970618 [Indexed for MEDLINE]
Author information:
(1)Department of Dermatology, Wake Forest School of Medicine, Winston-Salem,
North Carolina. spencerhawkins@gmail.com.
PURPOSE: Patients report wanting more information about psoriasis and clear
expectations from the onset of therapy. Dermatologists do not think patients
receive or internalize adequate information. There isa need for further
explanation of treatment regimens to increase knowledge, compliance, and patient
satisfaction. Recent advancements in web technology have the potential to improve
these psoriasis outcomes.
METHODS: A web based application was created to educate psoriasis patients using
video, graphics, and textual information. An investigator blinded, randomized,
controlled study evaluated the website's efficacy in 50 psoriasis patients at
Wake Forest Baptist Health Dermatology. Patients were randomized into two groups:
Group 1 received a link to the educational web app and a survey following their
visit; Group 2 received a link to the survey with no educational web app. The
survey assessed patient knowledge, self reported adherence to medication, and
adequacy of addressing concerns. Twenty two patients completed the study.
RESULTS: Patients in the web app group scored an average of 11/14 on the
psoriasis knowledge quiz, whereas patients in the control group scored an average
of 9/14 for an improvement of roughly 18% (p=0.008, n=22).
CONCLUSION: Web app based education via DermPatientEd.Com is an efficient way to
improve knowledge, but we did not demonstrate improvements in self-reported
medication adherence or the ability to address concerns of psoriasis patients.
Author information:
(1)Savannakhet Provincial Health Department, Phonsavangnuea village,
Kaysone-Phomvihan district, Savannakhet, Lao PDR.
(2)SATREPS Project for Parasitic Diseases, Vientiane Capital, Lao PDR.
(3)3Department of Global Health, School of Health Sciences, University of the
Ryukyus, 207 Uehara, Nishihara-cho, Okinawa, 903-0215 Japan.
(4)4Department of Tropical Medicine and Malaria, Research Institute, National
Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo,
162-8655 Japan.
(5)5Institut Pasteur du Laos, Ministry of Health, Sisattanak district, Vientiane
Capital, Lao PDR.
(6)6National Center for Laboratory and Epidemiology, Ministry of Health,
Sisattanak district, Vientiane Capital, Lao PDR.
(7)7Graduate School of International Health Development, Nagasaki University,
1-12-4 Sakamoto, Nagasaki-shi, Nagasaki, 852-8523 Japan.
(8)8Center of Malariology, Parasitology and Entomology, Ministry of Health,
Sisattanak district, Vientiane Capital, Lao PDR.
DOI: 10.1186/s41182-019-0140-2
PMCID: PMC6346530
PMID: 30700969
Conflict of interest statement: The protocol for the present study was approved
by the National Ethics Committee for Health Research, Ministry of Health, Lao PDR
(No. 003/2015). Prior to the survey, surveyors explained to the participants the
details of this study, such as its purpose, that participation was voluntary, the
information that would be collected, and how data would be kept and managed.
Written informed consent was obtained from each respondent.Not applicable.The
authors declare that they have no competing interests.Springer Nature remains
neutral with regard to jurisdictional claims in published maps and institutional
affiliations.
Author information:
(1)Department of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen
University, 123 Mitraparb Road, Amphur Muang, Khon Kaen, Thailand, 40002.
(2)Medical Library, Faculty of Medicine, Khon Kaen University, 123 Mittraparp
Highway, Khon Kaen, Thailand, 40002.
DOI: 10.1002/14651858.CD009957.pub2
PMCID: PMC6464760
PMID: 28109160 [Indexed for MEDLINE]
Abraham NS(1), Naik AD(2), Street RL Jr(3), Castillo DL(4), Deswal A(5),
Richardson PA(2), Hartman CM(4), Shelton G Jr(2), Fraenkel L(6).
Author information:
(1)Division of Gastroenterology, Mayo Clinic, Scottsdale, AZ, USA ; Divison of
Healthcare Policy and Research, Department of Health Services Research,
Rochester, MN, USA.
(2)Center for Innovations in Quality, Effectiveness, and Safety at the Michael E
DeBakey VA Medical Center, Houston, TX, USA ; Department of Medicine, Baylor
College of Medicine, Houston, TX, USA.
(3)Center for Innovations in Quality, Effectiveness, and Safety at the Michael E
DeBakey VA Medical Center, Houston, TX, USA ; Department of Medicine, Baylor
College of Medicine, Houston, TX, USA ; Department of Communication, Texas A&M
University, College Station, TX, USA.
(4)Center for Innovations in Quality, Effectiveness, and Safety at the Michael E
DeBakey VA Medical Center, Houston, TX, USA.
(5)Cardiology, Michael E DeBakey VAMC, Houston, TX, USA.
(6)Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA ;
Department of Medicine, Yale University, New Haven, CT, USA.
PURPOSE: For years, older patients have been prescribed multiple blood-thinning
medications (complex antithrombotic therapy [CAT]) to decrease their risk of
cardiovascular events. These therapies, however, increase risk of adverse
bleeding events. We assessed patient-reported trade-offs between cardioprotective
benefit, gastrointestinal bleeding risk, and burden of self-management using
adaptive conjoint analysis (ACA). As ACA could be a clinically useful tool to
obtain patient preferences and guide future patient-centered care, we examined
the clinical application of ACA to obtain patient preferences and the impact of
ACA on medication adherence.
PATIENTS AND METHODS: An electronic ACA survey led 201 respondents through
medication risk-benefit trade-offs, revealing patients' preferences for the CAT
risk/benefit profile they valued most. The post-ACA prescription regimen was
categorized as concordant or discordant with elicited preferences. Adherence was
measured using VA pharmacy refill data to measure persistence of use prior to and
1 year following preference-elicitation. Additionally, we analyzed qualitative
interviews of 56 respondents regarding their perception of the ACA and the
preference elicitation experience.
RESULTS: Participants prioritized 5-year cardiovascular benefit over preventing
adverse events. Medication side effects, medication-associated activity
restrictions, and regimen complexity were less important than bleeding risk and
cardioprotective benefit. One year after the ACA survey, a 15% increase in
adherence was observed in patients prescribed a preference-concordant CAT
strategy. An increase of only 6% was noted in patients prescribed a
preference-discordant strategy. Qualitative interviews showed that the ACA
exercise contributed to increase inpatient activation, patient awareness of
preferences, and patient engagement with clinicians about treatment decisions.
CONCLUSION: By working through trade-offs, patients actively clarified their
preferences, learning about CAT risks, benefits, and self-management. Patients
with medication regimens concordant with their preferences had increased
medication adherence at 1 year compared to those with discordant medication
regimens. The ACA task improved adherence through enhanced patient engagement
regarding treatment preferences.
DOI: 10.2147/PPA.S91553
PMCID: PMC4657793
PMID: 26640372
Author information:
(1)Division of Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy,
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Cecil
G. Sheps Center for Health Services Research, University of North Carolina at
Chapel Hill, Chapel Hill, North Carolina. Electronic address:
betsy_sleath@unc.edu.
(2)Division of Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy,
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
(3)Department of Ophthalmology, School of Medicine, Duke University, and Durham
VA Medical Center, Health Services Research and Development, Durham, North
Carolina.
(4)Glaucoma Service, Kittner Eye Center, University of North Carolina at Chapel
Hill, Chapel Hill, North Carolina.
(5)Department of Ophthalmology, Emory University School of Medicine, Atlanta,
Georgia.
(6)Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center,
University of Utah, Salt Lake City, Utah.
(7)Department of Science and Mathematics, Husson University, Bangor, Maine.
(8)Department of Ophthalmology, University of Maryland, Baltimore, Maryland;
Department of Ophthalmology, University of Michigan, Ann Arbor, Michigan;
Department of International Health, Bloomberg School of Public Health, and
Department of Ophthalmology, School of Medicine, Johns Hopkins University,
Baltimore, Maryland.
DOI: 10.1016/j.ophtha.2014.11.001
PMCID: PMC4994530
PMID: 25542521 [Indexed for MEDLINE]
Author information:
(1)College of Nursing, Gachon University, 191 Hambakmeo-ro, Yeonsu-gu, Incheon,
21936, South Korea.
(2)College of Nursing, Gachon University, 191 Hambakmeo-ro, Yeonsu-gu, Incheon,
21936, South Korea. yulhamin@gmail.com.
DOI: 10.1186/s12905-018-0522-3
PMCID: PMC5858147
PMID: 29551094 [Indexed for MEDLINE]
Garofalo R(1)(2), Kuhns LM(3)(4), Hotton A(5), Johnson A(3)(6), Muldoon A(3),
Rice D(3).
Author information:
(1)Division of Adolescent Medicine, Ann & Robert H. Lurie Children's Hospital,
225 E. Chicago Avenue, Box 161, Chicago, IL, 60611, USA.
rgarofalo@luriechildrens.org.
(2)Department of Pediatrics, Northwestern University, Feinberg School of
Medicine, Chicago, IL, USA. rgarofalo@luriechildrens.org.
(3)Division of Adolescent Medicine, Ann & Robert H. Lurie Children's Hospital,
225 E. Chicago Avenue, Box 161, Chicago, IL, 60611, USA.
(4)Department of Pediatrics, Northwestern University, Feinberg School of
Medicine, Chicago, IL, USA.
(5)Division of Infectious Diseases, John H. Stroger Hospital of Cook County,
Chicago, IL, USA.
(6)AIDS Foundation of Chicago, Chicago, IL, USA.
DOI: 10.1007/s10461-015-1192-x
PMCID: PMC4788595
PMID: 26362167 [Indexed for MEDLINE]
Author information:
(1)*Carman and Ann Adams Department of Pediatrics, Wayne State University,
Detroit, MI; †Department of Psychiatry, Medical University of South Carolina,
Charleston, SC.
DOI: 10.1097/DBP.0000000000000093
PMCID: PMC4180784
PMID: 25186121 [Indexed for MEDLINE]
Hennein R(1)(2), Hwang SJ(1)(2), Au R(3)(4)(5), Levy D(1)(2), Muntner P(6), Fox
CS(1)(2)(7), Ma J(1)(2).
Author information:
(1)Framingham Heart Study, Framingham, Massachusetts, USA.
(2)Population Sciences Branch, Division of Intramural Research, National Heart,
Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland,
USA.
(3)Department of Neurology, Boston University School of Medicine, Boston,
Massachusetts, USA.
(4)Department of Anatomy and Neurobiology, Boston University School of Medicine,
Boston, Massachusetts, USA.
(5)Department of Epidemiology, Boston University School of Public Health, Boston,
Massachusetts, USA.
(6)Department of Epidemiology, University of Alabama at Birmingham, Birmingham,
Alabama, USA.
(7)Department of Genetics and Pharmacogenomics, Merck Research Labs, Boston,
Massachusetts, USA.
DOI: 10.1111/imj.13687
PMCID: PMC5889324
PMID: 29193523 [Indexed for MEDLINE]
1245. BMC Health Serv Res. 2015 Aug 17;15:332. doi: 10.1186/s12913-015-0998-6.
The effects of patient education programs on medication use among asthma and COPD
patients: a propensity score matching with a difference-in-difference regression
approach.
Author information:
(1)Department of Economics, University of Saskatchewan, S7N5A5, Saskatoon, SK,
Canada. Nazmi.Sari@usask.ca.
(2)Saskatchewan Health Quality Council, Saskatoon, Canada. mosman@hqc.sk.ca.
Kawano Y(1)(2)(3), Shiroyama M(1), Kanazawa K(4), Suzuki YA(4), Ohtsu I(5)(6)(7).
Author information:
(1)Graduate School of Life and Environmental Sciences, University of Tsukuba,
Tsukuba, Japan.
(2)Microbiology Research Center for Sustainability, University of Tsukuba,
Tsukuba, Japan.
(3)Euglena Co., Ltd, Tokyo, Japan.
(4)Biochemical Laboratory, Saraya Co. Ltd, Kashiwara, Japan.
(5)Graduate School of Life and Environmental Sciences, University of Tsukuba,
Tsukuba, Japan. ohtsu.iwao.fm@u.tsukuba.ac.jp.
(6)Microbiology Research Center for Sustainability, University of Tsukuba,
Tsukuba, Japan. ohtsu.iwao.fm@u.tsukuba.ac.jp.
(7)Euglena Co., Ltd, Tokyo, Japan. ohtsu.iwao.fm@u.tsukuba.ac.jp.
DOI: 10.1186/s13568-019-0817-2
PMCID: PMC6588663
PMID: 31227937
Author information:
(1)Duke University, Durham, NC, USA. molly.copeland@duke.edu.
(2)Duke University, Durham, NC, USA.
(3)King Abdulaziz University, Jeddah, Saudi Arabia.
(4)The Pennsylvania State University, University Park, PA, 16801, USA.
Social isolation is broadly associated with poor mental health and risky
behaviors in adolescence, a time when peers are critical for healthy development.
However, expectations for isolates' substance use remain unclear. Isolation in
adolescence may signal deviant attitudes or spur self-medication, resulting in
higher substance use. Conversely, isolates may lack access to substances, leading
to lower use. Although treated as a homogeneous social condition for teens in
much research, isolation represents a multifaceted experience with structurally
distinct network components that present different risks for substance use. This
study decomposes isolation into conceptually distinct dimensions that are then
interacted to create a systematic typology of isolation subtypes representing
different positions in the social space of the school. Each isolated position's
association with cigarette, alcohol, and marijuana use is tested among 9th grade
students (n = 10,310, 59% female, 83% white) using cross-sectional data from the
PROSPER study. Different dimensions of isolation relate to substance use in
distinct ways: unliked isolation is associated with lower alcohol use, whereas
disengagement and outside orientation are linked to higher use of all three
substances. Specifically, disengagement presents risks for cigarette and
marijuana use among boys, and outside orientation is associated with cigarette
use for girls. Overall, the adolescents disengaged from their school network who
also identify close friends outside their grade are at greatest risk for
substance use. This study indicates the importance of considering the distinct
social positions of isolation to understand risks for both substance use and
social isolation in adolescence.
DOI: 10.1007/s10964-018-0860-3
PMCID: PMC6045973
PMID: 29774451 [Indexed for MEDLINE]
Directions of the relationship between substance use and depressive symptoms from
adolescence to young adulthood.
Author information:
(1)Carolina Population Center, University of North Carolina at Chapel Hill, 206
West Franklin St., Room 208, Chapel Hill, NC 27516, United States; Department of
Maternal and Child Health, Gillings School of Global Public Health, University of
North Carolina at Chapel Hill, 401 Rosenau Hall, CB #7445, Chapel Hill, NC
27599-7445, United States. Electronic address: wilkina@live.unc.edu.
(2)Carolina Population Center, University of North Carolina at Chapel Hill, 206
West Franklin St., Room 208, Chapel Hill, NC 27516, United States; Department of
Maternal and Child Health, Gillings School of Global Public Health, University of
North Carolina at Chapel Hill, 401 Rosenau Hall, CB #7445, Chapel Hill, NC
27599-7445, United States.
(3)Carolina Population Center, University of North Carolina at Chapel Hill, 206
West Franklin St., Room 208, Chapel Hill, NC 27516, United States; Department of
Biostatistics, Gillings School of Global Public Health, University of North
Carolina at Chapel Hill, 135 Dauer Drive, CB #7420, Chapel Hill, NC 27599-7420,
United States.
PURPOSE: Both substance use and depression are common in adolescence and often
comorbid. Past research has produced conflicting results on whether there is a
temporal relationship and if so, in which direction it operates and how it may
vary by sex. The purpose of this paper is to explore the longitudinal,
potentially bidirectional, relationships between high-frequency substance use and
depressive symptoms from adolescence into young adulthood for males and females.
METHODS: Using data from the National Longitudinal Study of Adolescent to Adult
Health we investigated longitudinal associations between high frequency substance
use (alcohol, cigarettes, and marijuana) and depressive symptoms. The linear
mixed effects models were stratified by sex and used a lagged measure of the
dependent variable to test temporal relationships. A random intercept was used
for respondent ID.
RESULTS: Increases in depressive symptoms were significantly associated with a
later increase of about a half day in marijuana use frequency for males and
nearly a two day increase in smoking frequency for females. Conversely, increases
in smoking frequency were significantly associated with approximately a 0.6-point
increase for females and 0.4-point increase for males in depressive symptoms at a
later wave.
CONCLUSIONS: Results indicate a bidirectional relationship between smoking and
depressive symptoms for females. For males, there was evidence supporting
self-medication with marijuana and for smoking being associated with later
increases in depressive symptoms. Results inform how substance use and depression
screening, prevention and treatment efforts should be paired and targeted for
males and females.
DOI: 10.1016/j.addbeh.2016.03.036
PMCID: PMC4884464
PMID: 27100470 [Indexed for MEDLINE]
Author information:
(1)Department of Nursing, University of Gondar College of Medicine and Health
Science, P. O. Box: 196, Gondar, Ethiopia.
(2)Department of Epidemiology and Biostatistics, Institute of Public Health,
University of Gondar College of Medicine and Health Science, P. O. Box: 196,
Gondar, Ethiopia.
DOI: 10.1186/s12912-016-0165-3
PMCID: PMC4949890
PMID: 27436991
Canino G(1), Shrout PE(2), Vila D(1), Ramírez R(1), Rand C(3).
Author information:
(1)a Behavioral Sciences Institute, University of Puerto Rico, Medical Sciences
Campus , San Juan , Puerto Rico .
(2)b Department of Psychology , New York University , New York , NY , USA , and.
(3)c The Johns Hopkins School of Medicine , Baltimore , MD , USA.
DOI: 10.3109/02770903.2015.1057846
PMCID: PMC4811660
PMID: 26786240 [Indexed for MEDLINE]
Jarbøl DE(1), Larsen PV(2), Gyrd-Hansen D(3), Søndergaard J(1), Brandt C(1),
Leppin A(4), Barfoed BL(1), Nielsen JB(1).
Author information:
(1)Research Unit of General Practice, Department of Public Health, University of
Southern Denmark, J.B. Winsløws Vej 9, DK-5000 Odense C, Denmark.
(2)Research Unit of Epidemiology, Biostatistics and Biodemography, Department of
Public Health, University of Southern Denmark, J.B. Winsløws Vej 9, DK-5000
Odense C, Denmark.
(3)COHERE, Department of Public Health & Department of Business and Economics,
University of Southern Denmark, J.B. Winsløws Vej 9, DK-5000 Odense C, Denmark.
(4)Unit for Health Promotion Research, Department of Public Health, University of
Southern Denmark, Niels Bohrs Vej 9, DK-6700 Esbjerg, Denmark.
Author information:
(1)1 Department of Psychiatry, John H. Stroger Hospital of Cook County , Chicago,
Illinois.
(2)2 Department of Psychology, Loyola University Chicago , Illinois.
(3)3 Nova Southeastern University , Fort Lauderdale, Florida.
DOI: 10.1089/apc.2015.0351
PMCID: PMC4948258
PMID: 27410496 [Indexed for MEDLINE]
Purcell C(1), Cameron S(2), Lawton J(3), Glasier A(4), Harden J(3).
Author information:
(1)MRC/CSO Social and Public Health Sciences Unit, University of Glasgow,
Glasgow, UK.
(2)Chalmers Centre for Sexual and Reproductive Health (NHS Lothian), Edinburgh,
UK.
(3)Usher Institute of Population Health Sciences and Informatics, University of
Edinburgh, Edinburgh, UK.
(4)Obstetrics and Gynaecology, Queen's Medical Research Institute, University of
Edinburgh, Edinburgh, UK.
DOI: 10.1111/1471-0528.14690
PMCID: PMC5724679
PMID: 28421651 [Indexed for MEDLINE]
DiBenedetti DB(1), Zhou X(2), Reynolds M(2), Ogale S(3), Best JH(3).
Author information:
(1)RTI Health Solutions, Research Triangle Park, NC, USA. ddibenedetti@rti.org.
(2)RTI Health Solutions, Research Triangle Park, NC, USA.
(3)Genentech, Inc., South San Francisco, CA, USA.
DOI: 10.1007/s40744-015-0011-1
PMCID: PMC4883252
PMID: 27747496
Author information:
(1)National University of Ireland, Galway, Ireland.
PMCID: PMC4577014
PMID: 26389860 [Indexed for MEDLINE]
1256. BMC Health Serv Res. 2016 Apr 23;16:145. doi: 10.1186/s12913-016-1384-8.
Author information:
(1)Pharmaceutical Care Research Group, Department of Pharmaceutical Sciences,
University of Basel, Basel, Switzerland. markus.messerli@unibas.ch.
(2)Division of General Practice, Department of Medicine, University Medical
Centre Freiburg, Freiburg, Germany.
(3)Division of Clinical Psychology and Psychiatry, Department of Psychology,
University of Basel, Basel, Switzerland.
(4)Pharmaceutical Care Research Group, Department of Pharmaceutical Sciences,
University of Basel, Basel, Switzerland.
DOI: 10.1186/s12913-016-1384-8
PMCID: PMC4842295
PMID: 27108410 [Indexed for MEDLINE]
Poor medication adherence and risk of relapse associated with continued cannabis
use in patients with first-episode psychosis: a prospective analysis.
Schoeler T(1), Petros N(1), Di Forti M(1), Klamerus E(1), Foglia E(1), Murray
R(1), Bhattacharyya S(2).
Author information:
(1)Department of Psychosis Studies, Institute of Psychiatry, Psychology &
Neuroscience, King's College London, London, UK.
(2)Department of Psychosis Studies, Institute of Psychiatry, Psychology &
Neuroscience, King's College London, London, UK. Electronic address:
sagnik.2.bhattacharyya@kcl.ac.uk.
Comment in
Lancet Psychiatry. 2017 Aug;4(8):578-579.
BACKGROUND: Cannabis use following the onset of first-episode psychosis has been
linked to both increased risk of relapse and non-adherence with antipsychotic
medication. Whether poor outcome associated with cannabis use is mediated through
an adverse effect of cannabis on medication adherence is unclear.
METHODS: In a prospective analysis of data acquired from four different adult
inpatient and outpatient units of the South London and Maudsley Mental Health
National Health Service Foundation Trust in London, UK, 245 patients were
followed up for 2 years from the onset of first-episode psychosis. Cannabis use
after onset of psychosis was assessed by self-reports in face-to-face follow-up
interviews. Relapse data were collected from clinical notes using the WHO Life
Chart Schedule. This measure was also used to assess medication adherence on the
basis of both face-to-face interviews and clinical notes. Patients were included
if they had a diagnosis of first-episode non-organic or affective psychosis
according to ICD-10 criteria, and were aged between 18 and 65 years when referred
to local psychiatric services. We used structural equation modelling analysis to
estimate whether medication adherence partly mediated the effects of continued
cannabis use on risk of relapse. The primary outcome variable was relapse,
defined as admission to a psychiatric inpatient unit after exacerbation of
symptoms within 2 years of first presentation to psychiatric services.
Information on cannabis use over the first 2 years after onset of psychosis was
investigated as a predictor variable for relapse. Medication adherence was
assessed as a mediator variable on the basis of clinical records and self-report
data. Study researchers (TS, NP, EK, and EF) rated the adherence.
FINDINGS: 397 patients who presented with their first episode of psychosis
between April 12, 2002, and July 26, 2013 had a follow-up assessment until
September, 2015. Of the 397 patients approached for followed up, 133 refused to
take part in this study and 19 could not be included because of missing data. 91
(37%) of 245 patients with first-episode psychosis had a relapse over the 2 years
of follow-up. Continued cannabis use predicted poor outcome, including risk of
relapse, number of relapses, length of relapse, and care intensity at follow-up.
In controlled structural equation modelling analyses, medication adherence partly
mediated the effect of continued cannabis use on outcome, including risk of
relapse (proportion mediated=26%, βindirect effects=0·08, 95% CI 0·004 to 0·16),
number of relapses (36%, βindirect effects=0·07, 0·003 to 0·14), time until
relapse (28%, βindirect effects=-0·26, -0·53 to 0·001) and care intensity (20%,
βindirect effects=0·06, 0·004 to 0·11) but not length of relapse (6%, βindirect
effects=0·03, -0·03 to 0·09). The adjusted models explained moderate amounts of
variance for outcomes defined as risk of relapse (R2=0·25), number of relapses
(R2=0·21), length of relapse (R2=0·07), time until relapse (R2=0·08), and care
intensity index (R2=0·15).
INTERPRETATION: Between 20% and 36% of the adverse effects of continued cannabis
use on outcome in psychosis might be mediated through the effects of cannabis use
on medication adherence. Interventions directed at medication adherence could
partly help mitigate the harm from cannabis use in psychosis.
FUNDING: This study is funded by the National Institute of Health Research (NIHR)
Clinician Scientist award.
Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access
article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights
reserved.
DOI: 10.1016/S2215-0366(17)30233-X
PMCID: PMC5522816
PMID: 28705600 [Indexed for MEDLINE]
Author information:
(1)UCL Interaction Centre, University College London, UK.
(2)Faculty of Engineering, Universidad Autónoma Baja California, Mexicali,
Mexico.
DOI: 10.1177/2055207616678707
PMCID: PMC6001179
PMID: 29942574
Dedefo MG(1), Ejeta BM(2), Wakjira GB(3), Mekonen GF(3), Labata BG(3).
Author information:
(1)Clinical Pharmacy Unit, Department of Pharmacy, College of Health Sciences,
Wollega University, Nekemte, Oromia, Ethiopia. mohamedg@wollegauniversity.edu.et.
(2)Pharmaceutics Unit, Department of Pharmacy, College of Health Sciences,
Wollega University, Nekemte, Oromia, Ethiopia.
(3)Clinical Pharmacy Unit, Department of Pharmacy, College of Health Sciences,
Wollega University, Nekemte, Oromia, Ethiopia.
DOI: 10.1186/s13104-019-4258-4
PMCID: PMC6454742
PMID: 30961663 [Indexed for MEDLINE]
DOI: 10.2147/PPA.S156043
PMCID: PMC5995298
PMID: 29922042
Groat D(1), Grando MA(1)(2), Soni H(1), Thompson B(2), Boyle M(2), Bailey M(2),
Cook CB(1)(2).
Author information:
(1)1 Arizona State University Department of Biomedical Informatics, Scottsdale,
AZ, USA.
(2)2 Mayo Clinic Arizona Division of Endocrinology, Scottsdale, AZ, USA.
DOI: 10.1177/1932296816666538
PMCID: PMC5478025
PMID: 27587370 [Indexed for MEDLINE]
Author information:
(1)Rosetown Pharmasave (Currie), Rosetown.
(2)College of Pharmacy and Nutrition (Evans, Mansell, Perepelkin, Jorgenson),
University of Saskatchewan, Saskatoon, Saskatchewan.
DOI: 10.1177/1715163519827980
PMCID: PMC6512182
PMID: 31156733
PMID: 27252999
1264. BMC Nurs. 2018 Mar 12;17:9. doi: 10.1186/s12912-018-0280-4. eCollection 2018.
Jember A(1), Hailu M(1), Messele A(2), Demeke T(3), Hassen M(1).
Author information:
(1)1Department of Medical Nursing, School of Nursing, College of Medicine and
Health Sciences, University of Gondar, Gondar, Ethiopia.
(2)2Unit of Community Health Nursing, School of Nursing, College of Medicine and
Health Sciences, University of Gondar, Gondar, Ethiopia.
(3)3Department of Pediatric and Child Health Nursing, School of Nursing, College
of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Background: A medication error (ME) is any preventable event that may cause or
lead to inappropriate medication use or patient harm. Voluntary reporting has a
principal role in appreciating the extent and impact of medication errors. Thus,
exploration of the proportion of medication error reporting and associated
factors among nurses is important to inform service providers and program
implementers so as to improve the quality of the healthcare services.
Methods: Institution based quantitative cross-sectional study was conducted among
397 nurses from March 6 to May 10, 2015. Stratified sampling followed by simple
random sampling technique was used to select the study participants. The data
were collected using structured self-administered questionnaire which was adopted
from studies conducted in Australia and Jordan. A pilot study was carried out to
validate the questionnaire before data collection for this study. Bivariate and
multivariate logistic regression models were fitted to identify factors
associated with the proportion of medication error reporting among nurses. An
adjusted odds ratio with 95% confidence interval was computed to determine the
level of significance.
Result: The proportion of medication error reporting among nurses was found to be
57.4%. Regression analysis showed that sex, marital status, having made a
medication error and medication error experience were significantly associated
with medication error reporting.
Conclusion: The proportion of medication error reporting among nurses in this
study was found to be higher than other studies.
DOI: 10.1186/s12912-018-0280-4
PMCID: PMC5848571
PMID: 29563855
Conflict of interest statement: Ethical clearance and approval was obtained from
Ethical Review Committee of School of Nursing, College of Medicine and Health
Sciences, University of Gondar and permission was obtained from the Ethical
Review Committees of each respective hospital. Consent form was put as a first
page of each questionnaire, and included the name of the researcher, the purpose
of the study, and a number of ethically based instructions. Participants were
assured that their involvement in the study was after having been informed about
the study without undue influence and could withdraw from the study at any time
without the need to give reason. The privacy of the participants was maintained
while they fill the questionnaire and confidentiality of the participants was
maintained by keeping anonymity and keeping the data only accessible by the
investigator. Although there may not be immediate and direct benefits for the
participants, nurses were informed of the benefits from the nursing knowledge
gained through the process. The participants were informed that there were no
financial benefits for participating in the research, no potential harms that
impact on employment, or social status, the utilization of the gathered data to
be used only for the intended research, and the publication of the results of the
study in a reputable journal with no identifiable information that links to the
participants.Not applicable.The authors declare that they have no competing
interests.Springer Nature remains neutral with regard to jurisdictional claims in
published maps and institutional affiliations.
Author information:
(1)Department of Psychiatry, Massachusetts General Hospital/Harvard Medical
School, One Bowdoin Square, 7th Floor, Boston, MA, 02114, USA,
jmagidson@partners.org.
DOI: 10.1007/s10461-014-0802-3
PMCID: PMC4247996
PMID: 24874725 [Indexed for MEDLINE]
1266. JMIR Cardio. 2017 Jul-Dec;1(2):e7. doi: 10.2196/cardio.8543. Epub 2017 Dec
12.
Author information:
(1)Division of Cardiology, Department of Medicine, UPMC Heart and Vascular
Institute, University of Pittsburgh, Pittsburgh, PA, United States.
(2)Center for Behavioral Health Smart Technology, Department of Medicine,
University of Pittsburgh, Pittsburgh, PA, United States.
(3)College of Computer and Information Science, Northeastern University, Boston,
MA, United States.
(4)Section of General Internal Medicine, Department of Medicine, Boston
University, Boston, MA, United States.
DOI: 10.2196/cardio.8543
PMCID: PMC5818980
PMID: 29473644
1267. Diabetes Metab Syndr Obes. 2019 May 24;12:789-800. doi: 10.2147/DMSO.S208324.
eCollection 2019.
Author information:
(1)College of Medicine and Dentistry, James Cook University, Townsville, QLD
4811, Australia.
(2)College of Public Health, Medical and Veterinary Sciences, James Cook
University, Townsville, QLD 4811, Australia.
DOI: 10.2147/DMSO.S208324
PMCID: PMC6538012
PMID: 31213866
1268. Diabetes Metab Res Rev. 2019 Mar;35(3):e3112. doi: 10.1002/dmrr.3112. Epub
2018
Dec 21.
Ji H(1), Chen R(1), Huang Y(1), Li W(1), Shi C(1), Zhou J(1).
Author information:
(1)Department of Endocrinology, Danyang People's Hospital of Jiangsu Province,
Danyang, China.
BACKGROUND: The aim of the study was to investigate whether simulation education
(SE) and case management had any effect on glycemic control in type 2 diabetes
(T2DM) patients.
METHODS: In this single center pilot trial, 100 T2DM patients who received
medication and basic diabetes self-management education (DSME) were randomly
divided into a control group (n = 50) and an experimental group (n = 50), who
received SE and a case management program. Evaluation of biochemical indices was
conducted at baseline and after 6 months. DSME consisted of 2-hour group
trainings weekly for 2 consecutive weeks followed by 2 × 30 minute education
sessions after 3 and 6 months. The SE program comprised additional 50-minute
video sessions 3 times in the first week and twice in the second week. The
experimental group was supervised by a nurse case manager, who followed up
participants at least once a month, and who conducted group sessions once every
3 months, focusing on realistic aspects of physical activity and nutrition, with
open discussions about setting goals and strategies to overcome barriers.
RESULTS: After 6 months, HbA1c, fasting plasma glucose, and postprandial blood
glucose level improvements were superior in the experimental group compared with
the control group (P < 0.05). Self-care behavior adherence scores of healthy diet
(P = 0.001), physical activity (P = 0.043), self-monitoring of blood glucose
(P < 0.001), and reducing risks (P < 0.001) were significantly increased in the
experimental group compared with the control group.
CONCLUSIONS: Simulation education and case management added to routine DSME
effectively improved glycemic control in T2DM patients.
DOI: 10.1002/dmrr.3112
PMCID: PMC6590464
PMID: 30520255 [Indexed for MEDLINE]
Author information:
(1)aCenter for Behavioral Cardiovascular Health, Department of Medicine, Columbia
University Medical Center, New York, New York bDepartment of Epidemiology,
University of Alabama at Birmingham, Birmingham, Alabama cDivision of General
Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York,
USA.
DOI: 10.1097/HJH.0000000000000503
PMCID: PMC4500106
PMID: 25909704 [Indexed for MEDLINE]
1270. Seizure. 2015 Nov;32:37-42. doi: 10.1016/j.seizure.2015.07.012. Epub 2015 Jul
29.
Gaus V(1), Kiep H(2), Holtkamp M(2), Burkert S(3), Kendel F(3).
Author information:
(1)Epilepsy-Center Berlin-Brandenburg, Department of Neurology,
Charité-Universitaetsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin,
Germany. Electronic address: verena.gaus@charite.de.
(2)Epilepsy-Center Berlin-Brandenburg, Department of Neurology,
Charité-Universitaetsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin,
Germany.
(3)Institute of Medical Psychology, Charité-Universitaetsmedizin Berlin,
Luisenstr. 57, 10117 Berlin, Germany.
DOI: 10.1016/j.seizure.2015.07.012
PMID: 26552559 [Indexed for MEDLINE]
Author information:
(1)Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
(2)Center for Neuropsychiatric Schizophrenia Research and Center for Clinical
Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Centre
Glostrup, University of Copenhagen, Copenhagen, Denmark.
(3)Faculty of Health and Medical Sciences, Department of Clinical Medicine,
University of Copenhagen, Copenhagen, Denmark.
(4)Department of Child and Adolescent Psychiatry, Institute of Psychiatry,
Psychology & Neuroscience, King's College, London, United Kingdom.
(5)Child and Adolescent Mental Health Center, Mental Health Services, Copenhagen,
Denmark.
DOI: 10.1093/ijnp/pyy070
PMCID: PMC6209856
PMID: 30124878 [Indexed for MEDLINE]
Evaluating the Usability and Usefulness of a Mobile App for Atrial Fibrillation
Using Qualitative Methods: Exploratory Pilot Study.
Author information:
(1)Partners Connected Health, Partners Healthcare, Boston, MA, United States.
(2)Heart Center, Massachusetts General Hospital, Boston, MA, United States.
(3)Harvard Medical School, Cambridge, MA, United States.
(4)Massachusetts General Hospital, Boston, MA, United States.
(#)Contributed equally
©Jaclyn Hirschey, Sunetra Bane, Moussa Mansour, Jodi Sperber, Stephen Agboola,
Joseph Kvedar, Kamal Jethwani. Originally published in JMIR Human Factors
(http://humanfactors.jmir.org), 15.03.2018.
DOI: 10.2196/humanfactors.8004
PMCID: PMC5876493
PMID: 29549073
1273. BMC Health Serv Res. 2015 Oct 1;15:445. doi: 10.1186/s12913-015-1086-7.
Author information:
(1)Center for Surgery and Public Health, Brigham and Women's Hospital, 1620
Tremont Street, Suite 4-020, Boston, MA, 02120, USA. Bsmalls@partners.org.
(2)Center for Surgery and Public Health, Brigham and Women's Hospital, 1620
Tremont Street, Suite 4-020, Boston, MA, 02120, USA. Gregoryc@musc.edu.
(3)Center for Surgery and Public Health, Brigham and Women's Hospital, 1620
Tremont Street, Suite 4-020, Boston, MA, 02120, USA. zollerjs@musc.edu.
(4)Department of Healthcare Leadership and Management, College of Health
Professions, Medical University of South Carolina, 151-B Rutledge Ave, MSC 962,
Charleston, SC, 29425, USA. zollerjs@musc.edu.
(5)Center for Health Disparities Research, Medical University of South Carolina,
135 Rutledge Ave, Room 280, MSC 593, Charleston, SC, 29425, USA. egedel@musc.edu.
(6)Division of General Internal Medicine and Geriatrics, Department of Medicine,
Medical University of South Carolina, 135 Rutledge Ave, RT 12th Floor, P.O. Box
250591, Charleston, SC, 29425, USA. egedel@musc.edu.
DOI: 10.1186/s12913-015-1086-7
PMCID: PMC4589943
PMID: 26428459 [Indexed for MEDLINE]
Association between Social Support and Self-Care Behaviors in Adults with Chronic
Obstructive Pulmonary Disease.
Chen Z(1), Fan VS(2)(3), Belza B(1), Pike K(1), Nguyen HQ(1)(4).
Author information:
(1)1 School of Nursing and.
(2)3 Division of Pulmonary and Critical Care Medicine, University of Washington,
Seattle, Washington.
(3)2 Veterans Affairs Puget Sound Health Care System, Seattle, Washington; and.
(4)4 Kaiser Permanente Southern California, Pasadena, California.
Comment in
Ann Am Thorac Soc. 2017 Sep;14(9):1385-1386.
RATIONALE: Higher social support is associated with a better quality of life and
functioning in adults with chronic obstructive pulmonary disease (COPD).
OBJECTIVES: To determine the association between structural and functional social
support and self-care behaviors in adults with COPD.
METHODS: This was a longitudinal study using data from the CASCADE (COPD
Activity: Serotonin Transporter, Cytokines, and Depression) study, which was
focused on depression and functioning in COPD. Physical activity was measured
with a validated accelerometer at baseline, year 1, and year 2. Additional
self-care behaviors included pulmonary rehabilitation attendance, smoking status,
receipt of influenza and/or pneumococcal vaccinations, and medication adherence.
Structural social support indicators included living status, being partnered,
number of close friends/relatives, and presence of a family caregiver. Functional
social support was measured with the Medical Outcomes Social Support Survey
(MOSSS). Mixed-effects and logistic regression models were used.
RESULTS: A total of 282 participants with Global Initiative for Chronic
Obstructive Lung Disease stage II to IV COPD were included (age, 68 ± 9 yr; 80%
men; FEV1% predicted, 45 ± 16). For physical activity, participants who lived
with others accrued 903 more steps per day than those who lived alone (95%
confidence interval [CI], 373-1,433; P = 0.001); increases in the MOSSS total
score were associated with more steps per day (β = 10; 95% CI, 2-18; P = 0.02).
The odds of pulmonary rehabilitation participation were more than 11 times higher
if an individual had a spouse or partner caregiver compared with not having a
caregiver (odds ratio [OR], 11.03; 95% CI, 1.93-62.97; P < 0.01). Higher
functional social support (MOSSS total score) was associated with marginally
lower odds of smoking (OR, 0.99; 95% CI, 0.98-1.00; P = 0.03) and higher odds of
pneumococcal vaccination (OR, 1.02; 95% CI, 1.00-1.03; P = 0.02). Social support
was not associated with influenza vaccination or medication adherence.
CONCLUSIONS: Structural social support, which was measured by reports of living
with others and having a caregiver, was respectively associated with higher
levels of physical activity and greater participation in pulmonary rehabilitation
in adults with COPD. Our findings reinforce the critical importance of the social
environment in shaping patients' success with self-care. Clinical Trial
registered with clinicaltrials.gov (NCT01074515).
DOI: 10.1513/AnnalsATS.201701-026OC
PMCID: PMC5711401
PMID: 28719225 [Indexed for MEDLINE]
Home medication support for childhood cancer: family-centered design and testing.
Walsh KE(1), Biggins C(2), Blasko D(2), Christiansen SM(2), Fischer SH(2), Keuker
C(2), Klugman R(2), Mazor KM(2).
Author information:
(1)Cincinnati Children's Hospital, Cincinnati, OH; The Meyers Primary Care
Institute; University of Massachusetts; Reliant Medical Group, Worcester; Beth
Israel Deaconess Medical Center, Boston; Kindred Healthcare, North Andover, MA;
and InterVision Media, Eugene, OR Kathleen.walsh@cchmc.org.
(2)Cincinnati Children's Hospital, Cincinnati, OH; The Meyers Primary Care
Institute; University of Massachusetts; Reliant Medical Group, Worcester; Beth
Israel Deaconess Medical Center, Boston; Kindred Healthcare, North Andover, MA;
and InterVision Media, Eugene, OR.
Comment in
J Oncol Pract. 2014 Nov;10(6):377-9.
PURPOSE: Errors in the use of medications at home by children with cancer are
common, and interventions to support correct use are needed. We sought to (1)
engage stakeholders in the design and development of an intervention to prevent
errors in home medication use, and (2) evaluate the acceptability and usefulness
of the intervention.
METHODS: We convened a multidisciplinary team of parents, clinicians, technology
experts, and researchers to develop an intervention using a two-step
user-centered design process. First, parents and oncologists provided input on
the design. Second, a parent panel and two oncology nurses refined draft
materials. In a feasibility study, we used questionnaires to assess usefulness
and acceptability. Medication error rates were assessed via monthly telephone
interviews with parents.
RESULTS: We successfully partnered with parents, clinicians, and IT experts to
develop Home Medication Support (HoMeS), a family-centered Web-based
intervention. HoMeS includes a medication calendar with decision support, a
communication tool, adverse effect information, a metric conversion chart, and
other information. The 15 families in the feasibility study gave HoMeS high
ratings for acceptability and usefulness. Half recorded information on the
calendar to indicate to other caregivers that doses were given; 34% brought it to
the clinic to communicate with their clinician about home medication use. There
was no change in the rate of medication errors in this feasibility study.
CONCLUSION: We created and tested a stakeholder-designed, Web-based intervention
to support home chemotherapy use, which parents rated highly. This tool may
prevent serious medication errors in a larger study.
DOI: 10.1200/JOP.2014.001482
PMCID: PMC4223710
PMID: 25336081 [Indexed for MEDLINE]
1276. Eur Respir J. 2017 Mar 8;49(3). pii: 1600987. doi: 10.1183/13993003.00987-
2016.
Print 2017 Mar.
White H(1)(2), Shaw N(2), Denman S(2), Pollard K(2), Wynne S(2), Peckham
DG(2)(3).
Author information:
(1)Nutrition and Dietetic Group, School of Clinical and Applied Science, Leeds
Beckett University, Leeds, UK H.White@leedsbeckett.ac.uk.
(2)Adult Cystic Fibrosis Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
(3)Leeds Institute of Biomedical and Clinical Sciences, Faculty of Medicine and
Health, University of Leeds, Leeds, UK.
The aim of this study was to characterise adherence in an adult population with
cystic fibrosis (CF) and to investigate if variation in lung function was a
predictor of adherence to treatment.The adherence of patients aged ≥16 years from
an adult CF centre was measured by medication possession ratio (MPR) and
self-report. Patients were assigned to one of three adherence categories (<50%,
50 to <80%, ≥80%) by their composite score (MPR). Ordinal regression was used to
identify predictors of adherence, including coefficient variation measures for
forced expiratory volume in 1 s (FEV1), weight and C-reactive protein
concentration, measured from 6 months and 12 months before baseline.MPR data for
106 of 249 patients (mean age 29.8±9.2 years) was retrieved, indicating a mean
adherence of 63%. The coefficient of variation for FEV1 was inversely related to
adherence and was a univariate predictor of adherence (6 months: OR 0.92, 95% CI
0.87-0.98, p=0.005; 12 months: OR 0.94, 95% CI 0.93-0.99, p=0.03) and remained
significant in the final models. The coefficient of variation of weight and
C-reactive protein were not predictive of adherence.The coefficient of variation
of FEV1 was identified as an objective predictor of adherence. Further evaluation
of this potential marker of adherence is now required.
DOI: 10.1183/13993003.00987-2016
PMID: 28275171 [Indexed for MEDLINE]
Author information:
(1)School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland.
(2)Department of General Practice, HRB Centre for Primary Care Research, Royal
College of Surgeons in Ireland, Dublin, Ireland.
OBJECTIVE: Growing evidence suggests that older adults are at an increased risk
of injurious falls when initiating antihypertensive medication, while the
evidence regarding long-term use of antihypertensive medication and the risk of
falling is mixed. However, long-term users who stop and start these medications
may have a similar risk of falling to initial users of antihypertensive
medication. Our aim was to evaluate the association between gaps in
antihypertensive medication adherence and injurious falls in older (≥65 years)
community-dwelling, long-term (≥≥1 year) antihypertensive users.
DESIGN: Prospective cohort study.
SETTING: Irish Community Pharmacy.
PARTICIPANTS: Consecutive participants presenting a prescription for
antihypertensive medication to 106 community pharmacies nationwide,
community-dwelling, ≥65 years, with no evidence of cognitive impairment, taking
antihypertensive medication for ≥1 year (n=938).
MEASURES: Gaps in antihypertensive medication adherence were evaluated from
linked dispensing records as the number of 5-day gaps between sequential supplies
over the 12-month period prior to baseline. Injurious falls during follow-up were
recorded via questionnaire during structured telephone interviews at 12 months.
RESULTS: At 12 months, 8.1% (n=76) of participants reported an injurious fall
requiring medical attention. The mean number of 5-day gaps in medication refill
behaviour was 1.47 (SD 1.58). In adjusted, modified Poisson models, 5-day
medication refill gaps at baseline were associated with a higher risk of an
injurious fall during follow-up (aRR 1.18, 95% CI 1.02 to 1.37, p=0.024).
CONCLUSION: Each 5-day gap in antihypertensive refill adherence increased the
risk of self-reported injurious falls by 18%. Gaps in antihypertensive adherence
may be a marker for increased risk of injurious falls. It is unknown whether
adherence-interventions will reduce subsequent risk. This finding is hypothesis
generating and should be replicated in similar populations.
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No
commercial re-use. See rights and permissions. Published by BMJ.
DOI: 10.1136/bmjopen-2018-022927
PMCID: PMC6429731
PMID: 30837246
Author information:
(1)Medicines Use Research Group, Department of Clinical Pharmacology and
Therapeutics, University of Malta, Msida, Malta.
DOI: 10.1177/2333794X19848670
PMCID: PMC6506913
PMID: 31106250
Factors related to poor asthma control in Latvian asthma patients between 2013
and 2015.
Smits D(1), Brigis G(1), Pavare J(2), Maurina B(3), Barengo NC(4).
Author information:
(1)a Faculty of Public Health and Social Welfare , Riga Stradins University ,
Riga , Latvia.
(2)b Faculty of Medicine , Riga Stradins University , Riga , Latvia.
(3)c Faculty of Pharmacy , Riga Stradins University , Riga , Latvia.
(4)d Herbert Wertheim College of Medicine , Florida International University ,
Miami , Florida , USA.
DOI: 10.1080/02813432.2017.1333302
PMCID: PMC5499319
PMID: 28585881 [Indexed for MEDLINE]
1280. Health Expect. 2016 Oct;19(5):1002-14. doi: 10.1111/hex.12392. Epub 2015 Aug
10.
Author information:
(1)Division of Psychiatry, UCL, London. n.morant@ucl.ac.uk.
(2)Department of Psychology, Anglia Ruskin University, Cambridge, UK.
(3)Department of Education and Social Care, Anglia Ruskin University, Cambridge,
UK.
BACKGROUND: Mental health care has lagged behind other health-care domains in
developing and applying shared decision making (SDM) for treatment decisions.
This is despite compatibilities with ideals of modern mental health care such as
self-management and recovery-oriented practice, and growing policy-level
interest. Psychiatric medication is a mainstay of mental health treatment, but
there are known problems with prescribing practices, and service users report
feeling uninvolved in medication decisions and concerned about adverse effects.
SDM has potential to produce better tailoring of psychiatric medication to
individuals' needs.
OBJECTIVES: This conceptual review argues that several aspects of mental health
care that differ from other health-care contexts (e.g. forms of coercion,
questions about service users' insight and disempowerment) may impact on
processes and possibilities for SDM. It is therefore problematic to uncritically
import models of SDM developed in other health-care contexts. We argue that
decision making for psychiatric medication is better understood in a broader way
that moves beyond the micro-social focus of a medical consultation.
Contextualizing specific medication-related consultations within longer term
relationships, and broader service systems enables recognition of the multiple
processes, actors and agendas that shape how psychiatric medication is
prescribed, managed and used, and which may facilitate or impede SDM.
CONCLUSION: A broad conceptualization of decision making for psychiatric
medication that moves beyond the micro-social can account for why SDM in this
domain remains a rarity. It has both conceptual and practical utility for
evaluating research evidence, identifying future research priorities and
highlighting fruitful ways of developing and implementing SDM in mental health
care.
© 2015 The Authors Health Expectations Published by John Wiley & Sons Ltd.
DOI: 10.1111/hex.12392
PMCID: PMC5053275
PMID: 26260361 [Indexed for MEDLINE]
Kimura M(1), Nakashima K(1), Usami E(1), Iwai M(1), Nakao T(1), Yoshimura T(1),
Mori H(1), Teramachi H(2).
Author information:
(1)Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Gifu 503-8502, Japan.
(2)Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Ogaki, Gifu
501-1196, Japan.
The aim of the present study was to clarify the adherence and awareness of oral
anticancer agents by type and therapeutic purpose in outpatients prescribed with
tegafur/gimeracil/oteracil potassium (S-1) or capecitabine. Outpatients
undergoing treatment with the S-1 or capecitabine oral anticancer agents at Ogaki
Municipal Hospital (Ogaki, Japan) in June 2013 completed a questionnaire survey
and the survey findings were evaluated. No significant differences in medication
adherence were identified between the patients administered S-1 and the patients
administered capecitabine (P=0.4586). In addition, no significant differences
were identified in therapeutic purpose between adjuvant therapy, and advanced and
recurrent therapies. However, for S-1 and capecitabine, medication adherence was
significantly higher in those undergoing combination therapy compared with those
undergoing monotherapy (P=0.0046). In addition, for patients taking S-1, the
median age for good adherence was significantly lower than that for insufficient
adherence (66.1±10.5 vs. 72.1±7.9 years, respectively; P=0.0035). Furthermore, a
significant negative correlation was identified between the awareness score of
research regarding the medication and age (n=109; P=0.0045). In conclusion, for
patients treated with S-1 or capecitabine, the type and therapeutic purpose of
oral anticancer agents did not affect medication adherence. Elderly patients
expressed a low interest in medications and typically exhibited insufficient
medication adherence. Therefore, patient guidance by pharmacists is important, as
it may result in improved medication adherence and an improved understanding of
the treatment side-effects in patients self-administering prescribed drugs.
DOI: 10.3892/ol.2015.3027
PMCID: PMC4467346
PMID: 26137068
Razoki B(1).
Author information:
(1)Department of Psychology, Erasmus School of Social and Behavioural Sciences,
Erasmus University Rotterdam, Rotterdam, the Netherlands,
bashar.razoki@gmail.com.
DOI: 10.2147/NDT.S178839
PMCID: PMC6214599
PMID: 30464474
Conflict of interest statement: Disclosure The author reports no conflicts of
interest in this work.
1283. Pharmacy (Basel). 2019 May 29;7(2). pii: E51. doi: 10.3390/pharmacy7020051.
Author information:
(1)Division of Pharmacy Practice, St. Louis College of Pharmacy, St. Louis, MO
63110, USA. roxane.took@stlcop.edu.
(2)Division of Pharmacy Practice and Administration, School of Pharmacy,
University of Missouri-Kansas City, Kansas City, MO 64108, USA. liuyif@umkc.edu.
(3)Division of Pharmacy Practice and Administration, School of Pharmacy,
University of Missouri-Kansas City, Kansas City, MO 64108, USA. kuehlp@umkc.edu.
DOI: 10.3390/pharmacy7020051
PMCID: PMC6630417
PMID: 31146447
Author information:
(1)Vanderbilt School of Nursing, Vanderbilt University, The Center for Research
and Innovation in Systems Safety (CRISS), Vanderbilt University Medical Center,
Nashville, TN, United States.
DOI: 10.2196/humanfactors.6338
PMCID: PMC5081481
PMID: 27733331
1285. BMC Med Res Methodol. 2019 May 9;19(1):95. doi: 10.1186/s12874-019-0743-7.
Sieben A(1), Bredie SJH(2), Luijten JCHBM(3), van Laarhoven CJHM(3), van Dulmen
S(4)(5)(6), van Onzenoort HAW(7)(8).
Author information:
(1)Department of Surgery, Division of Vascular Surgery, Radboud university
medical center, Geert Grooteplein 10, Postbus 9101, 6500 HB, Nijmegen, the
Netherlands. angelien.sieben@radboudumc.nl.
(2)Department of General Internal Medicine, Division of Vascular Medicine,
Radboud university medical center, Nijmegen, the Netherlands.
(3)Department of General Surgery, Radboud university medical center, Nijmegen,
the Netherlands.
(4)Department of Primary and Community Care, Radboud university medical center,
Radboud Institute for Health Sciences, Nijmegen, the Netherlands.
(5)NIVEL (Netherlands institute for health services research), Utrecht, the
Netherlands.
(6)Faculty of Health and Social Sciences, University of South-Eastern Norway,
Drammen, Norway.
(7)Department of Clinical Pharmacy, Amphia Hospital, Breda, the Netherlands.
(8)Department of Clinical Pharmacy and Toxicology, Maastricht University Medical
Center+, Maastricht, the Netherlands.
DOI: 10.1186/s12874-019-0743-7
PMCID: PMC6506957
PMID: 31072304
Levin JB(1), Tatsuoka C(2), Cassidy KA(3), Aebi ME(3), Sajatovic M(4).
Author information:
(1)Department of Psychiatry, Case Western Reserve University School of Medicine,
Cleveland, OH 44106, USA; Neurological and Behavioral Outcomes Center, University
Hospitals Case Medical Center, Cleveland, OH, USA. Electronic address:
Jennifer.levin@uhhospitals.org.
(2)Neurological and Behavioral Outcomes Center, University Hospitals Case Medical
Center, Cleveland, OH, USA; Department of Neurology, Case Western Reserve
University School of Medicine, Cleveland, OH 44106, USA.
(3)Department of Psychiatry, Case Western Reserve University School of Medicine,
Cleveland, OH 44106, USA.
(4)Department of Psychiatry, Case Western Reserve University School of Medicine,
Cleveland, OH 44106, USA; Neurological and Behavioral Outcomes Center, University
Hospitals Case Medical Center, Cleveland, OH, USA.
DOI: 10.1016/j.comppsych.2014.11.023
PMCID: PMC4369431
PMID: 25617964 [Indexed for MEDLINE]
Kauppi P(1), Peura S(2), Salimäki J(2), Järvenpää S(3), Linna M(4), Haahtela
T(1).
Author information:
(1)Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki
00250, Finland.
(2)Association of Finnish Pharmacies, Helsinki 00500, Finland.
(3)MedCare Ltd., Äänekoski 44100, Finland.
(4)The Institute of Healthcare Engineering, Management and Architecture, Aalto
00076, Finland.
BACKGROUND: Asthma and allergies are common and cause substantial burden in
symptoms and suffering, hospitalizations and medication costs. However, despite
the high prevalence, asthma burden has already decreased in Finland in 2000s.
OBJECTIVE: We carried out an asthma barometer survey in all Finnish pharmacies to
study changes in asthma severity and control, and use of health care services
from 2001 to 2010.
METHODS: Asthma severity, comorbid allergic conditions, and use of medication and
health care services were assessed in subjects who purchased asthma or allergy
medication from the pharmacies all across the country during one week in 2001 and
again in 2010. In 2001, 3,062 patients (mean age, 49 years), and in 2010, 1,114
patients (mean age, 51 years) participated.
RESULTS: In 2001 90% and in 2010 73% of the respondents reported
physician-diagnosed asthma and were entitled to special reimbursement for their
drug costs, i.e., they needed regular maintenance treatment. In 2001, 10% of the
asthmatics regarded their disease as severe, compared with 4% in 2010, while the
figures for mild asthma were 45% and 62%, respectively (p < 0.001). The
proportion of patients needing emergency care during the last year decreased from
34% (2001) to 14% (2010) (p < 0.001) and the need for hospitalizations from 18%
to 6% (p < 0.001). Smoking reduced from 24% to 18% among asthmatics ( p = 0.002).
In 2010, risk factors for severe asthma were older age, comorbid atopic eczema,
and food allergy.
CONCLUSION: During ten years, self-reported asthma severity has reduced and
disease control improved in Finland.
DOI: 10.5415/apallergy.2015.5.1.32
PMCID: PMC4313758
PMID: 25653918
1288. J Clin Pharmacol. 2015 Jan;55(1):33-8. doi: 10.1002/jcph.368. Epub 2014 Jul
28.
Author information:
(1)University of Colorado Department of Emergency Medicine, Aurora, CO, USA;
Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado, USA;
Rocky Mountain Poison & Drug Center, Denver, Colorado, USA.
Author information:
(1)Department of General Practice, Western Gateway Building, University College
Cork, Cork, Ireland.
(2)Health Behaviour Change Research Group, School of Psychology, National
University of Ireland, Galway, Ireland.
DOI: 10.1186/s40814-017-0129-8
PMCID: PMC5357807
PMID: 28331631
1290. Front Pharmacol. 2019 Jul 5;10:721. doi: 10.3389/fphar.2019.00721.
eCollection
2019.
Blumenthal J(1), Pasipanodya EC(2), Jain S(3), Sun S(3), Ellorin E(1), Morris
S(1), Moore DJ(2).
Author information:
(1)Department of Medicine, University of California San Diego, La Jolla, CA,
United States.
(2)Department of Psychiatry, University of California San Diego, La Jolla, CA,
United States.
(3)Family Medicine and Public Health, University of California San Diego, La
Jolla, CA, United States.
DOI: 10.3389/fphar.2019.00721
PMCID: PMC6624646
PMID: 31333454
Author information:
(1)Group Health Research Institute, 1730 Minor Ave #1600, Seattle, WA, 98101,
USA, wu.582@osu.edu.
DOI: 10.1007/s12160-015-9702-7
PMCID: PMC4561195
PMID: 25837697 [Indexed for MEDLINE]
Tangled Up in Blue: Unraveling the Links Between Emotional Distress and Treatment
Adherence in Type 2 Diabetes.
Gonzalez JS(1)(2), Kane NS(3), Binko DH(3), Shapira A(3), Hoogendoorn CJ(3).
Author information:
(1)Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY
jeffrey.gonzalez@einstein.yu.edu.
(2)Departments of Medicine (Endocrinology) and Epidemiology & Population Health,
Albert Einstein College of Medicine, Bronx, NY.
(3)Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY.
DOI: 10.2337/dc16-1657
PMCID: PMC5127225
PMID: 27797932 [Indexed for MEDLINE]
Health Beliefs and Medication Adherence in Black Patients with Diabetes and Mild
Cognitive Impairment.
Author information:
(1)Department of Neurology, Sidney Kimmel Medical College of Thomas Jefferson
University, Philadelphia, PA; Department of Psychiatry, Sidney Kimmel Medical
College of Thomas Jefferson University, Philadelphia, PA; Department of
Ophthalmology, Sidney Kimmel Medical College of Thomas Jefferson University,
Philadelphia, PA. Electronic address: barry.rovner@jefferson.edu.
(2)Department of Psychiatry and Human Behavior, Sidney Kimmel Medical College of
Thomas Jefferson University, Philadelphia, PA.
Author information:
(1)Department of Practice and Policy, University College London School of
Pharmacy, London, UK ; Department of Pharmacy Practice, Faculty of Pharmacy,
Kuwait University, Kuwait City, Kuwait.
(2)Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University,
Kuwait City, Kuwait.
(3)Department of Practice and Policy, University College London School of
Pharmacy, London, UK.
(4)Department of Clinical Pharmacy, School of Pharmacy, University of California,
San Francisco, CA, USA.
DOI: 10.2147/PPA.S86719
PMCID: PMC4629974
PMID: 26604702
Characterization of Apps and Other e-Tools for Medication Use: Insights Into
Possible Benefits and Risks.
van Kerkhof LW(1), van der Laar CW, de Jong C, Weda M, Hegger I.
Author information:
(1)National Institute for Public Health and the Environment (RIVM), Centre for
Health Protection, Bilthoven, Netherlands. linda.van.kerkhof@rivm.nl.
DOI: 10.2196/mhealth.4149
PMCID: PMC4838755
PMID: 27052946
Author information:
(1)School of Public Health, Loma Linda University, Loma Linda, California, USA.
(2)Department of Public Health, Malamulo Adventist Hospital, Makwasa, Malawi.
(3)Promotores Academy, Institute for Community Partnerships, Loma Linda
University, Loma Linda, California, USA.
(4)Global Health Institute, Loma Linda University, Loma Linda, California, USA.
(5)Department of Family and Preventive Medicine, Loma Linda University Health,
Loma Linda, California, USA.
(6)Department of Medicine, Malamulo Adventist Hospital, Makwasa, Malawi.
BACKGROUND: The aim of this study was to understand the perceptions and
experiences of health education and self-management practices on Malamulo
Adventist Hospital type 2 diabetic patients.
METHODS: In this qualitative study, key informant interviews (KIIs; n=4) and
focus group discussions (3 FGDs; n=16) were conducted amongst type 2 diabetes
patients who had been treated at Malamulo Adventist Hospital in southern Malawi
at least once. Key informant interviews and focus group discussions were audio
recorded, transcribed verbatim and translated for analysis. Grounded theory
methods were used to identify line-by-line emerging codes and were categorized
and examined in Atlas.ti. The data was analyzed for emergent themes and supported
by critical quotes.
RESULTS: Content analysis revealed participants had a positive regard for the
diabetes education classes and had satisfactory health literacy. Participants
expressed their ability to integrate diabetes education, such as exercise into
their lifestyle. Due to financial constraints subjects experienced trouble
maintaining their medication regimen, and had difficulty adopting healthier
nutritional alternatives. Although patients expressed efficacy in controlling
their blood sugar they subsequently expressed having limited knowledge when
dealing with diabetes complications.
CONCLUSIONS: Diabetes self-management is comprised of a complex set of processes.
Patients with type 2 diabetes at Malamulo Adventist Hospital are deeply impacted
by these processes which includes their understanding of the disease process,
effects of medication, economic challenges to acquiring health care services and
medications, and one's unique life experience. For all patients with type 2
diabetes to successfully manage their condition, support from their family, the
medical community, and health policies must be readily available.
PMCID: PMC5610281
PMID: 28955418 [Indexed for MEDLINE]
Santos MA(1), Guimarães MDC(2), Helena ETS(3), Basso CR(1), Vale FC(1), Carvalho
WMDES(1), Alves AM(1), Rocha GM(4), Acurcio FA(2), Ceccato MDGB(2), do Prado RR,
Menezes PR(1), Nemes MIB(1).
Author information:
(1)Faculty of Medicine of University of Sao Paulo, Department of Preventive
Medicine, São Paulo, São Paulo.
(2)Federal University of Minas Gerais, Belo Horizonte, Minas Gerais.
(3)University of Blumenau, Blumenau, Santa Catarina.
(4)Federal University of São João Del-Rei, Divinópolis, Minas Gerais, Brazil.
DOI: 10.1097/MD.0000000000009015
PMCID: PMC5991539
PMID: 29912815 [Indexed for MEDLINE]
Author information:
(1)Department of Pharmacology, All India Institute of Medical Sciences, Bhopal,
Madhya Pradesh, India.
Modern medicine encompasses a holistic approach toward patient care that seeks to
integrate the social, psychological, and pathological aspects of a disease. In
line with this, the traditional model of improving treatment outcomes through
improved compliance or adherence has given way to the concept of "concordance"
that respects the integrity of the patient, autonomy, and self-determination. A
self-conscious patient actively and equally participating in her or his
comprehensive healthcare can bring a paradigm shift in the perceptions and
functioning of the healthcare sector. Medication concordance can be expected to
play a key role in improving patient well-being, clinical outcomes, and
healthcare delivery. However, it is fraught with numerous questions to be
addressed ranging from lack of clarity or standard protocol, medicolegal
intricacies, cultural-linguistic barriers, illiteracy, shortage of time,
infrastructure, and manpower. There are major challenges in the effective
implementation of this initiative which has definite potential to prove
beneficial in Indian healthcare settings. The success of this novel approach can
only be accomplished by coordinated, inclusive, and persistent efforts from all
participants of healthcare with fostering of a milieu of trust, belief, and
communication. A systematic literature search was conducted using key words from
relevant articles and MeSh terms on Google Scholar and PubMed. Data were
abstracted according to their relevance to subheadings of the review and
synthesis of concepts was done through multiple reviews by atleast two reviewers
for any subsection.
DOI: 10.4103/jfmpc.jfmpc_176_19
PMCID: PMC6510085
PMID: 31143713
Personalized behavior change program for glaucoma patients with poor adherence: a
pilot interventional cohort study with a pre-post design.
Newman-Casey PA(1), Niziol LM(1), Mackenzie CK(1), Resnicow K(2), Lee PP(1),
Musch DC(1)(3), Heisler M(4).
Author information:
(1)1Department of Ophthalmology and Visual Sciences, University of Michigan
Medical School, 1000 Wall Street, Ann Arbor, MI 48105 USA.
(2)2Department of Health Behavior and Health Education, University of Michigan
School of Public Health, Ann Arbor, MI 48105 USA.
(3)3Department of Epidemiology, University of Michigan School of Public Health,
Ann Arbor, MI 48105 USA.
(4)4Department of Internal Medicine, University of Michigan Medical School, Ann
Arbor, MI 48109 USA.
Background: About half of people with glaucoma do not adhere to their recommended
medications. Interventions for other chronic conditions have successfully
utilized reminder systems and motivational interviewing (MI)-based counseling.
This study was designed to pilot a personalized intervention that leverages these
strategies to assess their impact on medication adherence in glaucoma patients.
Methods: Glaucoma patients taking ≥ 1 medication will be pre-screened by
telephone survey for adherence to their medication(s). Those who self-report poor
adherence will be enrolled in a 3-month monitoring period to measure medication
adherence using electronic medication monitors. Participants who are non-adherent
(take </=80% of their medication doses) over the 3-month run in phase will be
eligible for the study. We plan to enroll 57 participants who are non-adherent to
their medications. Participants' adherence will then be continuously measured
with electronic medication monitors, by self-report, and via pharmacy refill data
over 2 years, during which two successively more resource-intensive components of
an intervention aimed to improve medication adherence will be administered. The
first component is a 3-month period of reminders (audio and/or visual) and text
message or automated phone call if a dose of medication is not taken within a
pre-specified time frame. The second component is a 6-month MI-based counseling
program with a trained glaucoma counselor. This component uses the eyeGuide, a
computer-based personalized behavior change program that enables
para-professional staff to provide personalized education and counseling for
glaucoma. The primary outcome is change in medication adherence. The secondary
outcomes include changes in clinical outcomes (intraocular pressure, IOP, and IOP
fluctuation) and psychosocial mediators of adherence (e.g., competence, energy
for change and satisfaction). Participants will undergo semi-structured
interviews at 12 months to give feedback about the counseling program in order to
improve it.
Discussion: This pilot study will provide insight into ways to deliver more
personalized health care to non-adherent glaucoma patients in order to better
support them in managing their chronic disease.
Trial registration: Retrospectively registered with ClinicalTrials.gov
(NCT03159247).
DOI: 10.1186/s40814-018-0320-6
PMCID: PMC6055343
PMID: 30062043
Author information:
(1)Secretaría de Salud, Instituto Nacional de Ciencias Médicas y Nutrición
"Salvador Zubirán", Clínica de Enfermedad Inflamatoria Intestinal. Ciudad de
México, México.
(2)Secretaría de Salud, Instituto Nacional de Psiquiatría "Ramón de la Fuente
Muñiz", Subdirección de Investigaciones Clínicas. Ciudad de México, México.
DOI: 10.24875/GMM.18004417
PMID: 31056588
1301. Child Adolesc Psychiatry Ment Health. 2017 Dec 29;11:68. doi:
10.1186/s13034-017-0207-y. eCollection 2017.
Author information:
(1)Regional Centre for Child and Youth Mental Health and Child Welfare, Faculty
of Medicine, NTNU, Trondheim, Norway.
(2)Department of Child and Adolescent Psychiatry, St. Olavs Hospital, Trondheim
University Hospital, Trondheim, Norway.
(3)Queen Maud University College, Trondheim, Norway.
DOI: 10.1186/s13034-017-0207-y
PMCID: PMC5747942
PMID: 29299058
Author information:
(1)School of Medicine, Psychology, University of Tasmania, Hobart, Australia.
(2)University of Tasmania, Hobart, Australia.
DOI: 10.2196/mhealth.7168
PMCID: PMC5434254
PMID: 28465281
Author information:
(1)Unidade de Diabetes, Serviço de Endocrinologia e Metabologia, Hospital das
Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São
Paulo, SP/Brazil.
DOI: 10.6061/clinics/2015(02)06
PMCID: PMC4351311
PMID: 25789518 [Indexed for MEDLINE]
Author information:
(1)Department of Community Medicine, Sri Manakula Vinayagar Medical College and
Hospital, Puducherry, India, Iran.
Context: A module-based training program for medical interns using World Health
Organization guide for good prescription along with the individual feedback on
their prescription was developed and implemented.
Objective: The objective of the study was to obtain the medical interns'
reactions to newly developed skill-based training program on rational treatment.
Study Setting: This study was conducted at the Department of Community Medicine.
Participants: A total of 96 medical interns were included in the study.
Study Design: A cross-sectional study consisting of retro-prefeedback and
open-ended questions about self-assessment of perceived skill on rational
treatment.
Analysis: Collected data were entered in Epi Info (3.5.4) and analyzed.
Results: After training, there was a significant increase in self-perceived
posttest scores of setting up the therapeutic objective for the treatment
(2.9-4.9), ability to select the correct drug (2.8-5.1), ability to select right
dose, schedule, and duration of drugs (2.5-4.9). and overall prescription skill
(2.9-4.9). There is a significant decrease in self-perceived scores in the skill
of practicing polypharmacy (4.1-2.5).
Conclusions: Overall, the training program was taken well and interns perceived
their skill on rational treatment was improved as shown by the feedback.
DOI: 10.4103/jfmpc.jfmpc_172_17
PMCID: PMC5848407
PMID: 29564272
van der Laan DM(1), Elders PJ(2), Boons CC(3), Bosmans JE(4), Nijpels G(2),
Hugtenburg JG(5).
Author information:
(1)Department of Clinical Pharmacology and Pharmacy and the Amsterdam Public
Health Research Institute, VU University Medical Center, Amsterdam, The
Netherlands. d.vanderlaan1@vumc.nl.
(2)Department of General Practice and Elderly Care Medicine and the Amsterdam
Public Health Research Institute, VU University Medical Center, Amsterdam, The
Netherlands.
(3)Department of Clinical Pharmacology and Pharmacy, VU University Medical
Center, Amsterdam, The Netherlands.
(4)Department of Health Sciences and the Amsterdam Public Health Research
Institute, Faculty of Earth and Life Sciences, VU University, Amsterdam, The
Netherlands.
(5)Department of Clinical Pharmacology and Pharmacy and the Amsterdam Public
Health Research Institute, VU University Medical Center, Amsterdam, The
Netherlands.
DOI: 10.1186/s13063-016-1696-3
PMCID: PMC5244518
PMID: 28103948 [Indexed for MEDLINE]
Health beliefs and desire to improve cholesterol levels among patients with
hyperlipidemia.
Zullig LL(1), Sanders LL(2), Thomas S(3), Brown JN(4), Danus S(5), McCant F(5),
Bosworth HB(6).
Author information:
(1)Center of Excellence for Health Services Research in Primary Care, Durham
Veterans Affairs Medical Center, Durham, USA; Department of Medicine, Duke
University, Durham, USA.
(2)Department of Medicine, Duke University, Durham, USA.
(3)Department of Biostatistics and Bioinformatics, Duke University, Durham, USA.
(4)Investigational Drug Service, Durham Veterans Affairs Medical Center, Durham,
USA.
(5)Center of Excellence for Health Services Research in Primary Care, Durham
Veterans Affairs Medical Center, Durham, USA.
(6)Center of Excellence for Health Services Research in Primary Care, Durham
Veterans Affairs Medical Center, Durham, USA; Department of Medicine, Duke
University, Durham, USA; Departments of Psychiatry and School of Nursing, Duke
University, Durham, USA. Electronic address: boswo001@mc.duke.edu.
DOI: 10.1016/j.pec.2015.11.025
PMCID: PMC5007622
PMID: 26673107 [Indexed for MEDLINE]
Author information:
(1)Assistant Professor, Department of Pharmacology, Saveetha Medical College ,
Chennai, India .
(2)Professor, Department of Pharmacology, Saveetha Medical College , Chennai,
India .
DOI: 10.7860/JCDR/2016/18387.7396
PMCID: PMC4843274
PMID: 27134888
Barker M(1)(2), D'Angelo S(3), Ntani G(3), Lawrence W(3)(4), Baird J(3)(4),
Jarman M(5), Vogel C(3)(4), Inskip H(3)(4), Cooper C(3)(4)(6), Harvey NC(3)(4);
MAVIDOS Study Group.
Author information:
(1)MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of
Southampton, Southampton, SO16 6YD, UK. meb@mrc.soton.ac.uk.
(2)NIHR Southampton Biomedical Research Centre, University Hospital Southampton
NHS Foundation Trust, University of Southampton, Southampton, UK.
meb@mrc.soton.ac.uk.
(3)MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of
Southampton, Southampton, SO16 6YD, UK.
(4)NIHR Southampton Biomedical Research Centre, University Hospital Southampton
NHS Foundation Trust, University of Southampton, Southampton, UK.
(5)Li Ka Shing Centre for Health Research Innovation, Department of Agriculture,
Food and Nutritional Science, University of Alberta, Edmonton, Canada.
(6)NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of
Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Botnar Research
Centre, University of Oxford, Oxford, UK.
DOI: 10.1007/s00198-016-3721-5
PMCID: PMC5404713
PMID: 27549309 [Indexed for MEDLINE]
Bragazzi NL(1), Ratto G(2), Luche ND(3), Canfori T(4), Proietti C(4), Del Puente
G(5).
Author information:
(1)Department of Health Sciences, School of Public Health, University of Genoa.
(2)Giacomo Puccini Conservatory of Music, La Spezia; Carlo Soliva School of
Music, Casale Monferrato.
(3)La Scala Theatre , Milan.
(4)Niccolò Paganini Conservatory of Music , Genoa.
(5)Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal
and Child Health, Section of Psychiatry, University of Genoa , Italy.
DOI: 10.4081/hpr.2015.1545
PMCID: PMC4768526
PMID: 26973965
Ligons FM(1), Mello-Thoms C(2), Handler SM(3), Romagnoli KM(1), Hochheiser H(4).
Author information:
(1)Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh,
PA, United States; Geriatric Pharmaceutical Outcomes and Geroinformatics Research
& Training Program, University of Pittsburgh, Pittsburgh, PA, United States.
(2)Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh,
PA, United States; Medical Radiation Sciences, The University of Sydney, Sydney,
NSW, Australia.
(3)Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh,
PA, United States; Geriatric Pharmaceutical Outcomes and Geroinformatics Research
& Training Program, University of Pittsburgh, Pittsburgh, PA, United States;
Division of Geriatric Medicine, University of Pittsburgh School of Medicine,
United States.
(4)Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh,
PA, United States; Geriatric Pharmaceutical Outcomes and Geroinformatics Research
& Training Program, University of Pittsburgh, Pittsburgh, PA, United States;
Intelligent Systems Program, University of Pittsburgh, Pittsburgh, PA, United
States. Electronic address: harryh@pitt.edu.
PURPOSE: To examine the relationship between cognitive status and the usability
of an integrated medication delivery unit (MDU) in older adults who reside in an
Assisted Living Facility (ALF).
METHODS: Subjects were recruited from a single ALF in Pittsburgh, PA. Usability
testing sessions required subjects to execute tasks essential to using EMMA(®)
(Electronic Medication Management Assistant), a Class II Federal Drug
Administration (FDA) approved integrated MDU. Video coding allowed for
quantification of usability errors observed during the testing sessions. Each
subject's cognitive status was assessed using the Mini Mental State Exam
(MMSE(®)) with scores <24 indicating cognitive impairment. Functional status was
assessed using the Lawton Instrumental Activities of Daily Living (IADL)
questionnaire, and a global assessment of subjective usability was assessed by
completing the System Usability Scale (SUS). Non-parametric statistics and
correlation analysis were used to determine whether significant differences
existed between cognitively impaired and non-impaired subjects.
RESULTS: Nineteen subjects were recruited and completed the protocol. The subject
pool was primarily white, female, 80+ and in possession of above average
education. There was a significant relationship between MMSE(®) scores and the
percentage of task success (z=-2.03, p=0.04). Subjects with MMSE(®) scores of 24+
(no cognitive impairment) successfully completed an average of 69.0% of tasks vs.
the 34.7% performance for those in the cognitively impaired group (<24). Six of
the unimpaired group also succeeded at meeting the 85% (6 out of 7 correct)
threshold. No subject with cognitive impairments (<24 MMSE(®)) completed more
than 5/7 (71.4%) of their tasks. Two of the impaired subjects failed all of the
tasks. Three of the MMSE(®)'s subsections (Date, Location and Spell 'world'
backwards) were found to be significantly related (p<0.05) to the percentage of
task success. Tasks success rates were related with IADL scores (z=-3.826,
p<0.0001), and SUS scores (r=0.467, p=0.0429).
CONCLUSIONS: Medication delivery units like EMMA(®) have the potential to improve
medication management by combining reminder systems with telemedical monitoring
and control capabilities. However, subjects judged to be "cognitively impaired"
(<24 MMSE(®)) scored a significantly smaller percentage of task success than the
"unimpaired" (>=24), suggesting that cognitive screening of patients prior to the
use of EMMA(®) may be advisable. Further studies are needed to test the use of
EMMA(®) amongst ALF residents without cognitive impairment to see if this
technology can improve medication adherence.
DOI: 10.1016/j.ijmedinf.2014.07.004
PMCID: PMC4268135
PMID: 25153770 [Indexed for MEDLINE]
Author information:
(1)New York University, New York, NY, USA.
Comment in
J Gen Intern Med. 2014 Nov;29(11):1531.
BACKGROUND: Older adults with asthma have low levels of adherence to their
prescribed inhaled corticosteroids (ICS). While prior research has identified
demographic and cognitive factors associated with ICS adherence among elderly
asthmatics, little is known about the strategies that older adults use to achieve
daily use of their medications. Identifying such strategies could provide
clinicians with useful advice for patients when counseling their patients about
ICS adherence.
OBJECTIVE: To identify medication use strategies associated with good ICS
adherence in older adults.
PARTICIPANTS: English-speaking and Spanish-speaking adults ages 60 years and
older with moderate or severe asthma were recruited from primary care and
pulmonary practices in New York City, NY, and Chicago, IL. Patients with chronic
obstructive pulmonary disease, other chronic lung diseases or a smoking history
of greater than 10 pack-years were excluded.
MAIN MEASURES: Medication adherence was assessed with the Medication Adherence
Rating Scale (MARS). Medication use strategies were assessed via open-ended
questioning. "Good adherence" was defined as a mean MARS score of 4.5 or greater.
KEY RESULTS: The rate of good adherence to ICS was 37 %. We identified six
general categories of medication adherence strategies: keeping the medication in
a usual location (44.2 %), integrating medication use with a daily routine (32.6
%), taking the medication at a specific time (21.7 %), taking the medication with
other medications (13.4 %), using the medication only when needed (13.4 %), and
using other reminders (11.9 %). The good adherence rate was greater among
individuals who kept their ICS medication in the bathroom (adjusted odds ration
[AOR] 3.05, 95 % CI 1.03-9.02, p = 0.04) or integrated its use into a daily
routine (AOR 3.77, 95 % CI: 1.62-8.77, p = 0.002).
CONCLUSIONS: Keeping ICS medications in the bathroom and integrating them into
daily routines are strategies associated with good ICS adherence. Clinicians
concerned with adherence should consider recommending these strategies to their
older asthmatic patients, although additional research is needed to determine
whether such advice would improve adherence behaviors.
DOI: 10.1007/s11606-014-2940-8
PMCID: PMC4238202
PMID: 25092003 [Indexed for MEDLINE]
Dong X(1).
Author information:
(1)Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL,
USA.
Elder self-neglect is a global public health and human rights issue that
threatens older people's health and safety. It commonly refers to refusal or
failure to provide oneself with care and protection in areas of food, water,
clothing, hygiene, medication, living environments, and safety precautions. While
prevalent, the status of self-neglecting individuals remains largely unclear, in
particular within community-dwelling populations. By reviewing the epidemiology
of elder self-neglect (definition, prevalence, risk factors, and consequences) to
date, the present paper identifies key research gaps such as methodological
inconsistency in case identification and measurement, and study designs that are
inadequate to determine risk factors of self-neglect. More importantly, in light
of the rapidly growing older population, relevant stakeholders (researchers,
healthcare providers, social service providers, legal professionals, community
organizations, and policymakers) must be prepared for an expected increasing
number of self-neglect cases and enlarging scope of the problem. Hence, in this
article, I present an overview regarding the management issues of elderly
self-neglect related to the detection, assessment, reporting and referral, and
decision-making capacity. Based on the current literature, the paper is aimed to
explore the present knowledge and challenges, and how they can pave the way for
solutions to self-neglect research, practice, and policy.
DOI: 10.2147/CIA.S103359
PMCID: PMC5472408
PMID: 28652717 [Indexed for MEDLINE]
McElfish PA(1), Bridges MD(1), Hudson JS(1), Purvis RS(1), Bursac Z(2), Kohler
PO(1), Goulden PA(3).
Author information:
(1)University of Arkansas for Medical Sciences Northwest, Fayetteville, Arkansas
(Dr McElfish, Dr Bridges, Prof Hudson, Dr Purvis, Dr Kohler)
(2)Division of Biostatistics and the Center for Population Sciences, Department
of Preventive Medicine for the College of Medicine at the University of Tennessee
Health Science Center, Memphis, Tennessee (Dr Bursac)
(3)Department of Medicine, Division of Endocrinology and Metabolism at the
University of Arkansas for Medical Sciences, Little Rock, Arkansas (Dr Goulden)
DOI: 10.1177/0145721715606806
PMCID: PMC5286927
PMID: 26363041 [Indexed for MEDLINE]
Author information:
(1)Program Coordinator. School of Pharmacy, KPJ International College. Penang
(Malaysia). chingsiang9@hotmail.com.
(2)Professor of Social and Administrative Pharmacy. School of Pharmaceutical
Sciences, Universiti Sains Malaysia. Penang (Malaysia). azmihassali@gmail.com.
(3)Faculty of Pharmacy, Universiti Teknologi MARA. Selangor (Malaysia).
chinfenneoh@gmail.com.
(4)Associate Professor. Faculty of pharmacy & Health Sciences, University of
Balochistan. Quetta (Pakistan). fahaduob@gmail.com.
DOI: 10.18549/PharmPract.2017.04.1074
PMCID: PMC5742001
PMID: 29317924
Blake Helms C(1), Turan JM(2), Atkins G(1), Kempf MC(3), Clay OJ(1), Raper JL(4),
Mugavero MJ(4), Turan B(5).
Author information:
(1)The Department of Psychology, University of Alabama at Birmingham, 415
Campbell Hall, Birmingham, AL, 35294-1170, USA.
(2)Department of Health Care Organization and Policy, University of Alabama at
Birmingham, Birmingham, AL, USA.
(3)Department of Family, Community and Health Systems and Department of Health
Behavior, University of Alabama at Birmingham, Birmingham, AL, USA.
(4)The Department of Medicine, University of Alabama at Birmingham, Birmingham,
AL, USA.
(5)The Department of Psychology, University of Alabama at Birmingham, 415
Campbell Hall, Birmingham, AL, 35294-1170, USA. bturanb@gmail.com.
Previous research suggests that people living with HIV (PLWH) sometimes
internalize HIV-related stigma existing in the community and experience feelings
of inferiority and shame due to their HIV status, which can have negative
consequences for treatment adherence. PLWH's interpersonal concerns about how
their HIV status may affect the security of their existing relationships may help
explain how internalized stigma affects adherence behaviors. In a cross-sectional
study conducted between March 2013 and January 2015 in Birmingham, AL, 180 PLWH
recruited from an outpatient HIV clinic completed previously validated measures
of internalized stigma, attachment styles, and concern about being seen while
taking HIV medication. Participants also self-reported their HIV medication
adherence. Higher levels of HIV-related internalized stigma, attachment-related
anxiety (i.e., fear of abandonment by relationship partners), and concerns about
being seen by others while taking HIV medication were all associated with worse
medication adherence. The effect of HIV-related internalized stigma on medication
adherence was mediated by attachment-related anxiety and by concerns about being
seen by others while taking HIV medication. Given that medication adherence is
vitally important for PLWH to achieve long-term positive health outcomes,
understanding interpersonal factors affecting medication adherence is crucial.
Interventions aimed at improving HIV treatment adherence should address
interpersonal factors as well as intrapersonal factors.
DOI: 10.1007/s10461-016-1320-2
PMCID: PMC4980279
PMID: 26864692 [Indexed for MEDLINE]
Cornelius T(1)(2), Jones M(1), Merly C(2), Welles B(2), Kalichman MO(2),
Kalichman SC(1)(2).
Author information:
(1)a Department of Psychological Sciences , University of Connecticut , Storrs ,
CT , USA.
(2)b Institute for Collaboration on Health, Intervention, and Policy, University
of Connecticut , Storrs , CT , USA.
DOI: 10.1080/09540121.2016.1258451
PMCID: PMC5291788
PMID: 27846730 [Indexed for MEDLINE]
1317. BMC Health Serv Res. 2018 Aug 8;18(1):623. doi: 10.1186/s12913-018-3440-z.
Wuyts J(1), Maesschalck J(2), De Wulf I(2), Foubert K(3), Boussery K(3), De
Lepeleire J(4), Foulon V(5).
Author information:
(1)Department of Pharmaceutical and Pharmacological Sciences, KU Leuven,
Herestraat 49 O&N2, Box 521, 3000, Leuven, Belgium. Joke.wuyts@kuleuven.be.
(2)Association of Belgian Pharmacies (APB), Archimedesstraat 11, 1000, Brussels,
Belgium.
(3)Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent
University, Ghent, Belgium.
(4)Department Public Health and Primary Care, ACHG, KU Leuven, Leuven, Belgium.
(5)Department of Pharmaceutical and Pharmacological Sciences, KU Leuven,
Herestraat 49 O&N2, Box 521, 3000, Leuven, Belgium.
BACKGROUND: Aged polymedicated patients are particularly vulnerable for
drug-related problems. A medication review aims to optimize the medication use of
patients and improve health outcomes. In this study, the effect of a
pharmacist-led medication use review is investigated for polymedicated ambulatory
older patients with the aim of implementing this pharmaceutical care intervention
across Belgium.
METHODS: This article describes the study protocol of the SIMENON study and
reports the results of the feasibility study, which aimed to test and optimize
this study protocol. In the SIMENON intervention study, 75 Belgian community
pharmacies each recruit 12 patients for a medication use review. For each
patient, the identified drug-related problems and subsequent interventions are
registered using the PharmDISC classification. In a subset of Dutch speaking
patients, a pretest-posttest single group design is used to measure the impact of
this review on patient related outcomes using questionnaires. The main outcome of
the study is the type and number of drug-related problems and related
interventions. A second outcome is the impact of the medication use review on
adherence, objectively measured with dispensing data. Evolution in medication
related quality of life is another outcome, measured with the Living with
Medicines Questionnaire version 3. Other patient reported outcomes include
adherence, self-management, patient satisfaction, fall incidents and use of
emergency healthcare services.
DISCUSSION: The findings of this study can provide data on the effectiveness of a
medication use review in the Belgian primary care setting. Furthermore, it will
provide insights in which patients benefit most of this intervention and
therefore facilitate the implementation of medication review in Belgium.
TRIAL REGISTRATION: ClinicalTrials.gov NCT03179722 . Retrospectively registered 7
June 2017.
DOI: 10.1186/s12913-018-3440-z
PMCID: PMC6083518
PMID: 30089523 [Indexed for MEDLINE]
Brandstetter S(1), Finger T(1), Fischer W(1), Brandl M(1), Böhmer M(2), Pfeifer
M(3), Apfelbacher C(1).
Author information:
(1)Medical Sociology, Institute of Epidemiology and Preventive Medicine,
University of Regensburg, Dr.-Gessler-Str. 17, 93051 Regensburg, Germany.
(2)Department of Public Health Microbiology and Infectious Disease Epidemiology,
Bavarian Health and Food Safety Authority, Oberschleissheim, Germany.
(3)Department of Pneumology, Klinik Donaustauf, Donaustauf, Germany.
DOI: 10.1186/s13601-017-0175-6
PMCID: PMC5680826
PMID: 29152167
Litwic AE(1), Compston JE(2), Wyman A(3), Siris ES(4), Gehlbach SH(3), Adachi
JD(5), Chapurlat R(6), Díez-Pérez A(7), LaCroix AZ(8), Nieves JW(9), Netelenbos
JC(10), Pfeilschifter J(11), Rossini M(12), Roux C(13), Saag KG(14), Silverman
S(15), Watts NB(16), Greenspan SL(17), March L(18), Gregson CL(1)(19), Cooper
C(1)(20), Dennison EM(21); Global Longitudinal Study of Osteoporosis in Women
(GLOW) Investigators.
Author information:
(1)MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton
General Hospital, Southampton, SO16 6YD, UK.
(2)Cambridge Biomedical Centre, Cambridge, UK.
(3)Center for Outcomes Research, University of Massachusetts Medical School,
Worcester, MA, USA.
(4)Department of Medicine, Columbia University Medical Center, New York, NY, USA.
(5)St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada.
(6)INSERM U831, Division of Rheumatology, Hôpital E. Herriot, Université de Lyon,
Lyon, France.
(7)Hospital del Mar-IMIM-Autonomous, University of Barcelona, Barcelona, Spain.
(8)Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
(9)Helen Hayes Hospital and Columbia University, West Haverstraw, NY, USA.
(10)Department of Endocrinology, VU University Medical Center, Amsterdam, The
Netherlands.
(11)Department of Internal Medicine III, Alfried Krupp Krankenhaus, Essen,
Germany.
(12)Department of Rheumatology, University of Verona, Verona, Italy.
(13)Cochin Hospital, Paris Descartes University, Paris, France.
(14)University of Alabama-Birmingham, Birmingham, AL, USA.
(15)Department of Rheumatology, Cedars-Sinai/UCLA, Los Angeles, CA, USA.
(16)Bone Health and Osteoporosis Center, University of Cincinnati, Cincinnati,
OH, USA.
(17)University of Pittsburgh, Pittsburgh, PA, USA.
(18)Faculty of Medicine and Department of Public Health, University of Sydney,
Sydney, Australia.
(19)Musculoskeletal Research Unit, Learning and Research Building, Southmead
Hospital, University of Bristol, Bristol, UK.
(20)Institute of Musculoskeletal Sciences, University of Oxford, Oxford, UK.
(21)MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton
General Hospital, Southampton, SO16 6YD, UK. emd@mrc.soton.ac.uk.
DOI: 10.1007/s00198-017-4200-3
PMCID: PMC5759929
PMID: 28861636 [Indexed for MEDLINE]
Reliability and known-group validity of the Arabic version of the 8-item Morisky
Medication Adherence Scale among type 2 diabetes mellitus patients.
Ashur ST(1), Shamsuddin K(1), Shah SA(1), Bosseri S(2), Morisky DE(3).
Author information:
(1)Department of Community Health, Universiti Kebangsaan Malaysia Medical Centre,
Kuala Lumpur, Malaysia.
(2)National Centre for Diabetes and Endocrinology, Tripoli, Libya.
(3)Department of Community Health Sciences, UCLA Fielding School of Public
Health, Los Angles, California, United States of America.
No validation study has previously been made for the Arabic version of the 8-item
Morisky Medication Adherence Scale (MMAS-8(©)) as a measure for medication
adherence in diabetes. This study in 2013 tested the reliability and validity of
the Arabic MMAS-8 for type 2 diabetes mellitus patients attending a referral
centre in Tripoli, Libya. A convenience sample of 103 patients self-completed the
questionnaire. Reliability was tested using Cronbach alpha, average inter-item
correlation and Spearman-Brown coefficient. Known-group validity was tested by
comparing MMAS-8 scores of patients grouped by glycaemic control. The Arabic
version showed adequate internal consistency (α = 0.70) and moderate split-half
reliability (r = 0.65). Known-group validity was supported as a significant
association was found between medication adherence and glycaemic control, with a
moderate effect size (ϕc = 0.34). The Arabic version displayed good psychometric
properties and could support diabetes research and practice in Arab countries.
Author information:
(1)Department of Ophthalmology, Friedrich-Alexander University, Erlangen,
Germany.
(2)Department of Ophthalmology, University of Cologne, Cologne, Germany.
(3)Department of Ophthalmology, Ludwig Maximilian University, Munich, Germany.
PURPOSE: The goal of this study was to determine the adherence of glaucoma
patients to their topical glaucoma medication. Furthermore, the relationships
between the adherence behavior and the patients' demographic data, clinical
characteristics, and their knowledge about glaucoma were evaluated.
METHODS: This was a prospective study of 123 patients with primary open-angle
glaucoma who were given two standardized questionnaires. The first questionnaire
at time point T1 comprised a knowledge assessment and the self-reported adherence
measures Adherence to Refills and Medication Scale 2 (ARMS2), visual analogue
scale for adherence (VAS-AD), and missed doses in the past 14 days. Two months
later at time point T2, a second questionnaire reevaluated the adherence measures
ARMS2, VAS-AD, and missed doses in the past 14 days.
RESULTS: There was a good correlation among all the three adherence measures at
T1 and T2. The mean values of ARMS2 were in the lower range, with 3.38 at T1 and
2.8 at T2. The VAS-AD detected that 18.5% of patients always took their eye drops
correctly, and 77.9% of patients reported not to have missed a single dose in the
past 14 days. There was no significant correlation between the patients'
demographic data or knowledge about glaucoma and the adherence measures ARMS2 or
VAS-AD. Among the clinical characteristics, only single-eye blindness showed a
significant correlation with VAS-AD.
CONCLUSION: In this study, no general relationships were found between medication
adherence and the patients' demographic data, clinical characteristics, or
knowledge about glaucoma. It may be assumed that more individualized strategies
are required to optimize adherence behavior.
DOI: 10.2147/PPA.S69943
PMCID: PMC4274150
PMID: 25565780
1322. Pharm Pract (Granada). 2015 Jan-Mar;13(1):533. Epub 2015 Mar 15.
Author information:
(1)Clinical Pharmacist, Pharmacy Department, Korle Bu Teaching Hospital. Accra (
Ghana ). suliben@yahoo.com.
(2)Principal Clinical Pharmacist, Emergency Department, Korle Bu Teaching
Hospital. Accra ( Ghana ). franklinach@hotmail.co.uk.
(3)Lecturer, School of Pharmacy, University of Ghana . Legon, Accra ( Ghana ).
iakretchy@yahoo.com.
PMCID: PMC4384271
PMID: 25883693
Author information:
(1)Interactive Research and Development, Karachi, Pakistan.
(2)Abdul Latif Jameel Poverty Action Lab, Massachusetts Institute of Technology,
Cambridge, MA, United States of America.
IMPORTANCE: The rapid uptake of mobile phones in low and middle-income countries
over the past decade has provided public health programs unprecedented access to
patients. While programs have used text messages to improve medication adherence,
there have been no high-powered trials evaluating their impact on tuberculosis
treatment outcomes.
OBJECTIVE: To measure the impact of Zindagi SMS, a two-way SMS reminder system,
on treatment success of people with drug-sensitive tuberculosis.
DESIGN: We conducted a two-arm, parallel design, effectiveness randomized
controlled trial in Karachi, Pakistan. Individual participants were randomized to
either Zindagi SMS or the control group. Zindagi SMS sent daily SMS reminders to
participants and asked them to respond through SMS or missed (unbilled) calls
after taking their medication. Non-respondents were sent up to three reminders a
day.
SETTING: Public and private sector tuberculosis clinics in Karachi, Pakistan.
PARTICIPANTS: Newly-diagnosed patients with smear or bacteriologically positive
pulmonary tuberculosis who were on treatment for less than two weeks; 15 years of
age or older; reported having access to a mobile phone; and intended to live in
Karachi throughout treatment were eligible to participate. We enrolled 2,207
participants, with 1,110 randomized to Zindagi SMS and 1,097 to the control
group.
MAIN OUTCOME: The primary outcome was clinically recorded treatment success based
upon intention-to-treat.
RESULTS: We found no significant difference between the Zindagi SMS or control
groups for treatment success (719 or 83% vs. 903 or 83%, respectively, p =
0·782). There was no significant program effect on self-reported medication
adherence reported during unannounced visits during treatment.
CONCLUSION: In this large-scale randomized controlled effectiveness trial of SMS
medication reminders for tuberculosis treatment, we found no significant impact.
TRIAL REGISTRATION: The trial was registered with ClinicalTrials.gov,
NCT01690754.
DOI: 10.1371/journal.pone.0162944
PMCID: PMC5089745
PMID: 27802283 [Indexed for MEDLINE]
Author information:
(1)Senior Scientist, Alcohol Research Group at the Public Health Institute, 6475
Christie Avenue, Suite 400, Emeryville CA 94608-1010; and Adjunct Associate
Professor, School of Public Health, University of California Berkeley.
(2)Senior Research Associate, Alcohol Research Group at the Public Health
Institute, 6475 Christie Avenue, Emeryville CA 94608-1010; and Lecturer,
California State University, East Bay.
This paper addresses the assumption that pathways to recovery from substance
abuse and dependence, and the language used to define one's relationship to
substances, translate to actual beliefs and behaviors in terms of substance use.
We draw on social representation theory, and use data from a large web-based
study (n=9,341) whose goal was to understand how individuals in recovery define
what recovery means to them. We often hear people say that they are "in
recovery," and present findings now provide empirical evidence of the prevalent
meanings of this ubiquitous expression. The belief that recovery is abstinence
was broadly held in our sample, especially among those exposed to treatment and
12-step self-help groups and who define themselves as in recovery-and most (but
not all) of such individuals are complete abstainers (no alcohol or drugs). In
contrast, among the "self-changers" who did not attend treatment or self-help
groups, the most common self-definition was used to have an alcohol or drug
problem but don't any more, half of whom believe that recovery is abstinence
while half do not, and only one-third are abstainers. Findings are of public
health relevance, as it is estimated that among American adults alone, 10% report
having had alcohol or drug problems but no longer do (The New York State Office
of Alcoholism and Substance Abuse Services (OASAS), 2012). In line with the
central concepts of social representation theory, people's pathways to recovery
have a strong effect on how they define themselves and their behaviors and
beliefs, but it is not universal.
DOI: 10.1177/2158244015574938
PMCID: PMC4566927
PMID: 26366325
Author information:
(1)uMotif Ltd, London, UK. rashmi@umotif.com.
DOI: 10.1186/1745-6215-15-374
PMCID: PMC4283131
PMID: 25257518 [Indexed for MEDLINE]
Author information:
(1)Pharmaceutical Care Research Group, Department of Pharmaceutical Sciences,
University of Basel, Basel, Switzerland.
(2)Division of Clinical Psychology, Department of Psychology, University of
Basel, Basel, Switzerland.
Background: Since 2010, Swiss pharmacists have been offering their patients a
Polymedication Check (PMC), a new cognitive pharmacy service in the form of a
medication review for patients taking ≥4 prescribed medicines for a period >3
months. While a first publication of this project reported on the impact of the
PMC on patients' adherence, the present paper focuses on humanistic outcomes.
Methods: This randomized controlled trial was conducted in 54 Swiss community
pharmacies. After recruitment, the intervention group underwent a PMC in the
pharmacy (T-0) and 28 weeks after T-0 (T-28), while the control group did not
receive the PMC until 28 weeks after the study started (T-28). A clinical
psychologist, blinded to the intervention, interviewed the patients 2 weeks (T-2)
and 16 weeks (T-16) after T-0. Interviewer and patient both rated patient's
knowledge of own medicines use. Furthermore, patients reported satisfaction with
their pharmacy and appraisal of their medicines use. The availability of a
written medication plan was assessed at T-16. Acceptance of the service was
measured using a patient's self-report questionnaire at T-28.
Results: General linear model analysis for knowledge about medicines revealed a
significant effect on the factor "group" (P=5.86, p=0.016), indicating that the
intervention group had higher ratings for knowledge about their medication at T-2
and T-16 compared to controls. The majority (83%) of patients judged the
counseling by the pharmacist as being helpful for their daily medication
management. Availability of a written medication plan was comparable in both
groups (52.5% vs 52.7%, p>0.05).
Conclusion: For the first time, the benefits of a complex pharmacist-led
intervention were evaluated in Swiss primary care with a randomized controlled
trial. The PMC increased patients' subjective knowledge of their medicines
compared to no medication review. The effect remained sustainable over time.
Recommendations resulting from the pharmacist-led service were highly appreciated
by the patients.
DOI: 10.2147/PPA.S160789
PMCID: PMC6016257
PMID: 29950820
Author information:
(1)Department of Neurology, University of British Columbia, Vancouver, Canada.
vdev@shaw.ca.
(2)Department of Psychiatry, Sunnybrook Health Sciences Centre, University of
Toronto, Toronto, Canada. antfeinstein@aol.com.
(3)A division of EMD Inc., EMD Serono, 2695 North Sheridan Way, Suite 200,
Mississauga, ON, L5K 2N6, Canada. Patrick.moriarty@emdserono.com.
Author information:
(1)Department of Applied Health Research, University College London, London,
United Kingdom.
(2)Department of Psychology, University of Cyprus, Nicosia, Cyprus.
(3)Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
(4)Private Practice, Athens, Greece.
(5)School of Pharmacy, University College London, London, United Kingdom.
DOI: 10.3389/fpsyg.2017.01769
PMCID: PMC5641822
PMID: 29075216
1329. BMC Med Res Methodol. 2017 Aug 3;17(1):118. doi: 10.1186/s12874-017-0394-5.
Chew BH(1)(2), Vos RC(3), Heijmans M(4), Shariff-Ghazali S(5), Fernandez A(6),
Rutten GEHM(3).
Author information:
(1)Department of Family Medicine, Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
chewboonhow@gmail.com.
(2)Julius Center for Health Sciences and Primary Care, Department of General
Practice, University Medical Center Utrecht, Huispost Str.6.131, P.O. Box 85500,
3508, GA, Utrecht, The Netherlands. chewboonhow@gmail.com.
(3)Julius Center for Health Sciences and Primary Care, Department of General
Practice, University Medical Center Utrecht, Huispost Str.6.131, P.O. Box 85500,
3508, GA, Utrecht, The Netherlands.
(4)NIVEL, Netherlands Institute for Health Services Research, Utrecht,
Netherlands.
(5)Department of Family Medicine, Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
(6)Department of Psychiatry, Faculty of Medicine and Health Sciences, Universiti
Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
BACKGROUND: Illness perceptions involve the personal beliefs that patients have
about their illness and may influence health behaviours considerably. Since an
instrument to measure these perceptions for Malay population in Malaysia is
lacking, we translated and examined the psychometric properties of the Malay
version of the Brief Illness Perception Questionnaire (MBIPQ) in adult patients
with type 2 diabetes mellitus.
METHODS: The MBIPQ has nine items, all use a 0-10 response scale, except the
ninth item about causal factors, which is an open-ended item. A standard
procedure was used to translate and adapt the English BIPQ into Malay language.
Construct validity was examined comparing item scores and scores on the Diabetes
Management Self-Efficacy Scale, the Morisky Medication Adherence Scale, the World
Health Organization Quality of Life-brief, the 9-item Patient Health
Questionnaire, the 17-item Diabetes Distress Scale, HbA1c and the presence of
complications. In addition, 2-week and 4-week test-retest reliability were
studied.
RESULTS: A total of 312 patients completed the MBIPQ. Out of this, 97 and 215
patients completed the 2- or 4-weeks test-retest reliability questionnaire,
respectively. Moderate inter-items correlations were observed between illness
perception dimensions (r = -0.31 to 0.53). MBIPQ items showed the expected
correlations with self-efficacy (r = 0.35), medication adherence (r = 0.29),
quality of life (r = -0.17 to 0.31) and depressive symptoms (r = -0.18 to 0.21).
People with severe diabetes-related distress also were more concern
(t-test = 4.01, p < 0.001) and experienced lower personal control (t-test = 2.07,
p = 0.031). People with any diabetes-related complication perceived the
consequences as more serious (t-test = 2.04, p = 0.044). The 2-week and 4-week
test-retest reliabilities varied between ICCagreement 0.39 to 0.70 and 0.58 to
0.78, respectively.
CONCLUSIONS: The psychometric properties of items in the MBIPQ are moderate. The
MBIPQ showed good cross-cultural validity and moderate construct validity.
Test-retest reliability was moderate. Despite the moderate psychometric
properties, the MBIPQ may be useful in clinical practice as it is a useful
instrument to elicit and communicate on patient's personal thoughts and feelings.
Future research is needed to establish its responsiveness and predictive
validity.
TRIAL REGISTRATION: ClinicalTrials.gov NCT02730754 registered on March 29, 2016;
NCT02730078 registered on March 29, 2016.
DOI: 10.1186/s12874-017-0394-5
PMCID: PMC5543429
PMID: 28774271 [Indexed for MEDLINE]
Author information:
(1)Ministry of Health, Medina, Saudi Arabia.
(2)Curtin University of Technology, School of Nursing and Midwifery, Perth,
Western Australia, Australia.
Publisher: الذين يراجعون مراكز2 ممارسات العاج الذاتي لدى مرضى السكري من النمط
خالد الجهني.الرعاية الصحية الولية في المدينة المنورة بالمملكة العربية السعودية،
لقد كان الغرض من هذه الدراسة تقدير تواتر أنشطة العاج. بول سنايدر،جارث كيندل
فتم استخدام النسخة. في المملكة العربية السعودية2 الذاتي لدى مرضى السكري من النمط
للتعرف عى ممارسات،العربية للستبيان الخاص بملخص أنشطة العناية الذاتية بالسكري
فكان مستوى جلوكوز الدم لدى.2 مريضا ا مصابا ا بالسكري من النمط210 العاج الذاتي لدى
15% 7 > فقط من المشاركين يدل عى ضبط جيد لسكر الدم )الهيموجلن الجليكوزولتي
لكن كثيرين، وأفاد معظمهم بأنهم أخذوا أدويتهم عى النحو الموصوف لهم.(لر/مليمول
منهم أظهروا مستويات منخفضة من اللتزام بممارسات العاج الذاتي الخرى )المتوسط
وكان الذكور وذوو الدخل المنخفض أقل ميا ا إلى ممارسة.( أيام في السبوع3.7 العام
وكان معظمهم قد تلقوا النصائح الساسية الخاصة بالضطاع.أنشطة العناية الذاتية
هناك فرص متاحة. لكن بعضهم فقط تلقوا معلومات أكثر تفصيا ا،بأنشطة العناية الذاتية
في المملكة العربية السعودية ولزيادة2 لتحسن ممارسات العاج الذاتي للسكري من النمط
نسبة المرضى الذين يحققون ضبطا ا جيدا ا لسكر الدم.Publisher: Pratiques d’auto-prise
en charge chez des patients atteints de diabète de type 2 fréquentant des centres
de soins de santé primaires à Médine (Arabie saoudite).L’objectif de la présente
étude était d’estimer la fréquence des activités d’auto-prise en charge chez des
personnes atteintes de diabète de type 2 en Arabie saoudite. La version en langue
arabe du questionnaire Summary of Diabetes Self-care Activities a été utilisée
pour identifier les pratiques d’auto-prise en charge chez 210 patients atteints
de diabète sucré de type 2. Seuls 15 % des participants présentaient un taux
glycémique révélateur d'un bon contrôle de leur glycémie (hémoglobine glycosylée
≤ 7 mmol/L). La plupart indiquaient avoir pris leur traitement comme prescrit,
mais ils étaient nombreux à présenter des taux d’observance faibles pour d'autres
pratiques d’auto-prise en charge (moyenne d’observance globale hebdomadaire : 3,7
jours sur sept). Les hommes et les personnes ayant des revenus plus faibles
étaient moins susceptibles de pratiquer des activités d’autosoins. Pour la
majorité, ils avaient reçu des conseils élémentaires pour réaliser des activités
d’autosoins, mais seule une minorité d'entre eux avait eu des informations plus
détaillées. Des opportunités existent pour améliorer les pratiques d’auto-prise
en charge du diabète de type 2 en Arabie saoudite et augmenter le pourcentage de
patients qui parviennent à un bon contrôle du taux de glycémie.
Wenzel SL(1), Rhoades H(1), Harris T(1), Winetrobe H(1), Rice E(1), Henwood B(1).
Author information:
(1)a USC School of Social Work , Los Angeles , CA , USA.
DOI: 10.1080/09540121.2016.1234690
PMCID: PMC6232079
PMID: 27654072 [Indexed for MEDLINE]
Blashill AJ(1), Bedoya CA, Mayer KH, O'Cleirigh C, Pinkston MM, Remmert JE,
Mimiaga MJ, Safren SA.
Author information:
(1)Massachusetts General Hospital, Boston, MA, USA, Ablashill@mgh.harvard.edu.
DOI: 10.1007/s10461-014-0925-6
PMCID: PMC4405426
PMID: 25331267 [Indexed for MEDLINE]
van Heuckelum M(1)(2), Linn AJ(3), Vandeberg L(3)(4), Hebing RCF(5), van Dijk
L(6)(7), Vervloet M(6), Flendrie M(1), Nurmohamed MT(5)(8), van Dulmen
S(6)(9)(10), van den Bemt BJF(2)(11)(12), van den Ende CHM(1)(13).
Author information:
(1)Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands.
(2)Department of Pharmacy, Sint Maartenskliniek, Nijmegen, The Netherlands.
(3)Amsterdam School of Communication Research, University of Amsterdam,
Amsterdam, The Netherlands.
(4)Centre for Language Studies, Radboud University, Nijmegen, The Netherlands.
(5)Department of Rheumatology, Amsterdam Rheumatology and Immunology Center,
Reade, Amsterdam, The Netherlands.
(6)Nivel (Netherlands Institute for Health Services Research), Utrecht, The
Netherlands.
(7)Department of PharmacoTherapy, -Epidemiology, & -Economics (PTEE), Groningen
Research Institute of Pharmacy, Faculty of Mathematics and Natural Sciences,
University of Groningen, Groningen, The Netherlands.
(8)Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, VU
University Medical Center, Amsterdam, The Netherlands.
(9)Radboud University Medical Center, Radboud Institute for Health Sciences,
Department of Primary and Community Care, Nijmegen, The Netherlands.
(10)Faculty of Health and Social Sciences, University of South-Eastern Norway,
Drammen, Norway.
(11)Department of Pharmacy, Radboud University Medical Center, Nijmegen, The
Netherlands.
(12)Department of Clinical Pharmacy and Toxicology, Maastricht University Medical
Centre+, Maastricht, The Netherlands.
(13)Department of Rheumatology, Radboud University Medical Center, Nijmegen, The
Netherlands.
OBJECTIVE: This study aims to explore the contribution of implicit attitudes and
associations towards conventional disease-modifying antirheumatic drugs
(cDMARDs), alongside explicit measures, on medication-taking behaviour and
clinical outcomes in adult patients with rheumatoid arthritis (RA).
METHODS: In this observational study, implicit attitudes (positive-negative) and
health-related associations (health-sickness) were measured with Single Category
Implicit Association Tests, whereas explicit outcomes were measured with a
bipolar evaluative adjective scale and the Beliefs about Medicines Questionnaire
Specific. The primary outcome of this study was medication-taking behaviour
subjectively measured by self-report (i.e. validated Compliance Questionnaire on
Rheumatology) and objectively measured with electronic drug monitors over a 3
month period. Spearman rank correlations were used to describe correlations
between implicit and explicit outcomes. Nested linear regression models were used
to assess the additional value of implicit measures over explicit measures and
patient-, clinical-, and treatment-related characteristics.
RESULTS: Of the 1659 initially-invited patients, 254 patients with RA agreed to
participate in this study. Implicit attitudes correlated significantly with
necessity-concerns differential (NCD) scores (ρ = 0.13, P = 0.05) and disease
activity scores (ρ = -0.17, P = 0.04), whereas implicit health-related
associations correlated significantly with mean scores for explicitly reported
health-related associations (ρ = 0.18, P = 0.004). Significant differences in
age, number of DMARDs, biologic DMARD use, NCD-scores, and self-reported correct
dosing were found between the four attitudinal profiles. Nested linear regression
models revealed no additional value of implicit measures in explaining
self-reported medication-taking behaviour and clinical outcomes, over and above
all other variables.
CONCLUSION: Implicit attitudes and associations had no additional value in
explaining medication-taking behaviour and clinical outcomes over and above often
used explicitly measured characteristics, attitudes and outcomes in the studied
population. Only age and NCD scores contributed significantly when the dependent
variable was correct dosing measured with self-report.
DOI: 10.1371/journal.pone.0221290
PMID: 31469852
Author information:
(1)Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute
for Pharmaceutical Sciences, University Utrecht, Utrecht, The Netherlands.
b.mertens@apotheekstevenshof.nl.
(2)SIR Institute for Pharmacy Practice and Policy, Theda Mansholtstraat 5b, 2331
JE, Leiden, The Netherlands. b.mertens@apotheekstevenshof.nl.
(3)SIR Institute for Pharmacy Practice and Policy, Theda Mansholtstraat 5b, 2331
JE, Leiden, The Netherlands.
(4)Geriatric Department, Jeroen Bosch Hospital, 's-Hertogenbosch, The
Netherlands.
(5)Department of General Practice and Elderly Care Medicine, EMGO Institute for
Health and Care Research, VU University Medical Center, Amsterdam, The
Netherlands.
(6)Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute
for Pharmaceutical Sciences, University Utrecht, Utrecht, The Netherlands.
DOI: 10.1007/s11096-018-0749-y
PMCID: PMC6394512
PMID: 30478494 [Indexed for MEDLINE]
Author information:
(1)Department of Psychiatry and Behavioral Medicine, Medical College of
Wisconsin, Center for AIDS Intervention Research (CAIR), 2071 North Summit
Avenue, Milwaukee, WI, 53202, USA. yuri@mcw.edu.
(2)Botkin Hospital for Infectious Diseases, Interdisciplinary Center for AIDS
Research and Training (ICART), St. Petersburg, Russia. yuri@mcw.edu.
(3)Department of Psychiatry and Behavioral Medicine, Medical College of
Wisconsin, Center for AIDS Intervention Research (CAIR), 2071 North Summit
Avenue, Milwaukee, WI, 53202, USA.
(4)Botkin Hospital for Infectious Diseases, Interdisciplinary Center for AIDS
Research and Training (ICART), St. Petersburg, Russia.
Over 1 million HIV infections have been diagnosed in Russia, and HIV care uptake
and viral suppression are very low. 241 HIV-positive individuals in St.
Petersburg were enrolled through social networks, provided blood for viral load
testing, and completed measures of medication-taking adherence, readiness, and
self-efficacy; psychosocial well-being; and substance use. Outcomes included
attending an HIV care appointment in the past 6 months, >90% ART adherence, and
undetectable viral load. 26% of participants had no recent care appointment, 18%
had suboptimal adherence, and 56% had detectable viral load. Alcohol use
consistently predicted all adverse health outcomes. Having no recent care visit
was additionally associated with being single and greater past-month drug
injection frequency. Poor adherence was additionally predicted by lower
medication-taking self-efficacy and lower anxiety. Detectable viral load was
additionally related to younger age. Comprehensive interventions to improve HIV
care in Russia must address substance abuse, anxiety, and medication-taking
self-efficacy.
DOI: 10.1007/s10461-016-1638-9
PMCID: PMC5476511
PMID: 27990579 [Indexed for MEDLINE]
Author information:
(1)1 Department of Clinical Pharmacy, Near East University Faculty of Pharmacy,
Nicosia, Northern Cyprus.
(2)2 Department of Clinical Pharmacy, Marmara University Faculty of Pharmacy,
Istanbul, Turkey.
(3)3 Department of Clinical Pharmacy, Hacettepe University Faculty of Pharmacy,
Ankara, Turkey.
DOI: 10.18553/jmcp.2017.23.5.573
PMID: 28448779 [Indexed for MEDLINE]
Medication use during pregnancy, gestational age and date of delivery: agreement
between maternal self-reports and health database information in a cohort.
Pisa FE(1)(2), Casetta A(3), Clagnan E(4), Michelesio E(5), Vecchi Brumatti L(6),
Barbone F(7)(8)(9).
Author information:
(1)Institute of Hygiene and Clinical Epidemiology, University Hospital of Udine,
Via Colugna 50, 33100, Udine, Italy. federica.pisa@uniud.it.
(2)Department of Medical and Biological Sciences, University of Udine, Udine,
Italy. federica.pisa@uniud.it.
(3)Department of Medical and Biological Sciences, University of Udine, Udine,
Italy. anica.casetta@uniud.it.
(4)Direzione Centrale Salute, Integrazione Socio Sanitaria e Politiche Sociali,
Regione Friuli Venezia Giulia, Udine, Italy. elena.clagnan@regione.fvg.it.
(5)INSIEL SpA, Udine, Italy. elisa.michelesio@insiel.it.
(6)Scientific Direction, Institute for Maternal and Child Health - IRCCS "Burlo
Garofolo", Trieste, Italy. vecchi@burlo.trieste.it.
(7)Institute of Hygiene and Clinical Epidemiology, University Hospital of Udine,
Via Colugna 50, 33100, Udine, Italy. fabio.barbone@uniud.it.
(8)Department of Medical and Biological Sciences, University of Udine, Udine,
Italy. fabio.barbone@uniud.it.
(9)Department of Medicine, University of Trieste, Trieste, Italy.
fabio.barbone@uniud.it.
BACKGROUND: Health databases are a promising resource for epidemiological studies
on medications safety during pregnancy. The reliability of information on
medications exposure and pregnancy timing is a key methodological issue. This
study (a) compared maternal self-reports and database information on medication
use, gestational age, date of delivery; (b) quantified the degree of agreement
between sources; (c) assessed predictors of agreement.
METHODS: Pregnant women recruited in a prenatal clinic in Friuli Venezia Giulia
(FVG) region, Italy, from 2007 to 2009, completed a questionnaire inquiring on
medication use during pregnancy, gestational age and date of delivery. Redeemed
prescriptions and birth certificate records were extracted from regional
databases through record linkage. Percent agreement, Kappa coefficient,
prevalence and bias-adjusted Kappa (PABAK) were calculated. Odds Ratio (OR), with
95% confidence interval (95% CI), of ≥ 1 agreement was calculated through
unconditional logistic regression.
RESULTS: The cohort included 767 women, 39.8% reported medication use, and 70.5%
were dispensed at least one medication. Kappa and PABAK indicated almost perfect
to substantial agreement for antihypertensive medications (Kappa 0.86, PABAK
0.99), thyroid hormones (0.88, 0.98), antiepileptic medications (1.00, 1.00),
antithrombotic agents (0.70, 0.96). PABAK value was greater than Kappa for
medications such as insulin (Kappa 0.50, PABAK 0.99), antihistamines for systemic
use (0.50, 0.99), progestogens (0.28, 0.79), and antibiotics (0.12, 0.63).
Adjusted OR was 0.48 (95% CI 0.26; 0.90) in ex- vs. never smokers, 0.64 (0.38;
1.08) in < high school vs. university, 1.55 (1.01; 2.37) in women with
comorbidities, 2.25 (1.19; 4.26) in those aged 40+ vs. 30-34 years. Gestational
age matched exactly in 85.2% and date of delivery in 99.5%.
CONCLUSIONS: For selected medications used for chronic conditions, the agreement
between self-reports and dispensing data was high. For medications with low to
very low prevalence of use, PABAK provides a more reliable measure of agreement.
Maternal reports and dispensing data are complementary to each other to increase
the reliability of information on the use of medications during pregnancy. Birth
certificates provide reliable data on the timing of pregnancy. FVG health
databases are a valuable source of data for pregnancy research.
DOI: 10.1186/s12884-015-0745-3
PMCID: PMC4660837
PMID: 26608022 [Indexed for MEDLINE]
Stämpfli D(1), Boeni F(1)(2), Gerber A(3), Bättig VAD(1), Weidmann R(4),
Hersberger KE(1), Lampert ML(1)(2).
Author information:
(1)Department of Pharmaceutical Sciences, University of Basel, Basel,
Switzerland.
(2)Clinical Pharmacy, Solothurner Spitaler AG, Olten, Switzerland.
(3)Gerontopharmakologie, Felix Platter-Hospital, Basel, Switzerland.
(4)Department of Psychology, University of Basel, Basel, Switzerland.
© Article author(s) (or their employer(s) unless otherwise stated in the text of
the article) 2018. All rights reserved. No commercial use is permitted unless
otherwise expressly granted.
DOI: 10.1136/bmjopen-2017-021284
PMCID: PMC6042600
PMID: 29950469
Sivanandy P(1), Maharajan MK(1), Rajiah K(1), Wei TT(2), Loon TW(2), Yee LC(2).
Author information:
(1)Department of Pharmacy Practice, School of Pharmacy.
(2)School of Pharmacy, International Medical University, Wilayah Persekutuan
Kuala Lumpur, Malaysia.
BACKGROUND: Patient safety is a major public health issue, and the knowledge,
skills, and experience of health professionals are very much essential for
improving patient safety. Patient safety and medication error are very much
associated. Pharmacists play a significant role in patient safety. The function
of pharmacists in the medication use process is very different from medical and
nursing colleagues. Medication dispensing accuracy is a vital element to ensure
the safety and quality of medication use.
OBJECTIVE: To evaluate the attitude and perception of the pharmacist toward
patient safety in retail pharmacies setup in Malaysia.
METHODS: A Pharmacy Survey on Patient Safety Culture questionnaire was used to
assess patient safety culture, developed by the Agency for Healthcare Research
and Quality, and the convenience sampling method was adopted.
RESULTS: The overall positive response rate ranged from 31.20% to 87.43%, and the
average positive response rate was found to be 67%. Among all the eleven domains
pertaining to patient safety culture, the scores of "staff training and skills"
were less. Communication openness, and patient counseling are common, but not
practiced regularly in the Malaysian retail pharmacy setup compared with those in
USA. The overall perception of patient safety of an acceptable level in the
current retail pharmacy setup.
CONCLUSION: The study revealed that staff training, skills, communication in
patient counseling, and communication across shifts and about mistakes are less
in current retail pharmacy setup. The overall perception of patient safety should
be improved by educating the pharmacists about the significance and essential of
patient safety.
DOI: 10.2147/PPA.S111537
PMCID: PMC4966676
PMID: 27524887
Blalock SJ(1), DeVellis BM, DeVellis RF, Chewning B, Jonas BL, Sleath BL.
Author information:
(1)Eshelman School of Pharmacy, University of North Carolina, Chapel Hill.
STACKing the odds for adolescent survival: health service factors associated with
full retention in care and adherence amongst adolescents living with HIV in South
Africa.
Cluver L(1)(2), Pantelic M(1)(3), Toska E(4)(5), Orkin M(6), Casale M(1)(7),
Bungane N(8), Sherr L(9).
Author information:
(1)Department of Social Policy and Intervention, University of Oxford, Oxford,
United Kingdom.
(2)Department of Psychiatry and Mental Health, University of Cape Town, Cape
Town, South Africa.
(3)Secretariat, International HIV/AIDS Alliance, Brighton, United Kingdom.
(4)AIDS and Society Research Unit, University of Cape Town, Cape Town, South
Africa.
(5)Department of Sociology, University of Cape Town, Cape Town, South Africa.
(6)MRC/Wits Developmental Pathways for Health Research Unit, School of Clinical
Medicine, University of the Witwatersrand, Johannesburg, South Africa.
(7)School of Public Health, University of the Western Cape, Cape Town, South
Africa.
(8)Department of Nursing, Fort Hare University, Alice, South Africa.
(9)Research Department of Global Health, University College London, London,
United Kingdom.
DOI: 10.1002/jia2.25176
PMCID: PMC6149366
PMID: 30240121 [Indexed for MEDLINE]
Author information:
(1)Pennington Biomedical Research Center,6400 Perkins Road,Baton Rouge,LA
70808,USA.
DOI: 10.1017/S0007114516003524
PMCID: PMC5282970
PMID: 27753427 [Indexed for MEDLINE]
Franssen M(1), Farmer A(1), Grant S(2), Greenfield S(2), Heneghan C(1), Hobbs
R(1), Hodgkinson J(2), Jowett S(2), Mant J(3), Martin U(2), Milner S(2), Monahan
M(2), Ogburn E(1), Perera-Salazar R(1), Schwartz C(1), Yu LM(1), McManus RJ(4).
Author information:
(1)Nuffield Department of Primary Care, Oxford University, Oxford, UK.
(2)Primary Care Clinical Sciences, University of Birmingham, Birmingham, UK.
(3)Department of Public Health and Primary Care, University of Cambridge,
Cambridge, UK.
(4)Nuffield Department of Primary Care, Oxford University, Oxford, UK.
richard.mcmanus@phc.ox.ac.uk.
DOI: 10.1186/s12872-017-0494-5
PMCID: PMC5307789
PMID: 28193176 [Indexed for MEDLINE]
Author information:
(1)Key Laboratory of Health Technology Assessment, Ministry of Health (Fudan
University), 130, DongAn Road, 200032, Shanghai, China. jyhuang@shmu.edu.cn.
(2)Department of Public Health Sciences, Clemson University, 525 Edwards Hall,
Clemson, SC, 29634-0745, USA.
DOI: 10.1186/s13063-016-1335-z
PMCID: PMC4840971
PMID: 27101823 [Indexed for MEDLINE]
Author information:
(1)Sheffield Hallam University,UK.
(2)University of Sheffield,UK.
(3)University of North Carolina at Chapel Hill,USA.
DOI: 10.1017/S1352465815000041
PMID: 25697236 [Indexed for MEDLINE]
Author information:
(1)Department of Anaesthesiology, Mahatma Gandhi Medical College and Research
Institute, Sri Balaji Vidyapeeth (Deemed to Be University), Puducherry, India.
(2)Department of Anaesthesiology, Sri Lakshmi Narayana Institute of Medical
Sciences, Puducherry, India.
DOI: 10.4103/joacp.JOACP_178_18
PMCID: PMC6598581
PMID: 31303712
Morrissey EC(1), Durand H(2), Nieuwlaat R(3), Navarro T(3), Haynes RB(3), Walsh
JC(2), Molloy GJ(2).
Author information:
(1)School of Psychology, National University of Ireland, Galway, Ireland.
e.morrissey6@nuigalway.ie.
(2)School of Psychology, National University of Ireland, Galway, Ireland.
(3)Department of Clinical Epidemiology and Biostatistics, McMaster University,
Hamilton, Ontario, Canada.
Erratum in
Syst Rev. 2017 Feb 17;6(1):30.
DOI: 10.1186/s13643-016-0278-5
PMCID: PMC4897948
PMID: 27267901 [Indexed for MEDLINE]
Author information:
(1)Affiliated Bayi Brain Hospital, Bayi Clinical College, Southern Medical
University, Beijing, China.
DOI: 10.1684/epd.2014.0722
PMID: 25644456 [Indexed for MEDLINE]
Ma X(#)(1), Zhang Y(#)(2), Zhang M(2), Li X(2), Yin H(2), Li K(3), Jing M(2).
Author information:
(1)China Center for Health Development Studies, Peking University, Beijing
100000, People's Republic of China.
(2)Department of Public Health, Shihezi University School of Medicine, Shihezi
832002, Xinjiang, People's Republic of China.
(3)Department of Orthopedics, The First Affiliated Hospital of the Medical
College, Shihezi University, Shihezi 832002, Xinjiang, People's Republic of
China.
(#)Contributed equally
DOI: 10.2147/PPA.S201707
PMCID: PMC6628968
PMID: 31371928
1350. Open Access Maced J Med Sci. 2018 Jun 17;6(6):1174-1179. doi:
10.3889/oamjms.2018.235. eCollection 2018 Jun 20.
Author information:
(1)Faculty of Pharmacy, Airlangga University, Gubeng, Surabaya, East Java,
Indonesia.
(2)Department of Neurology, Faculty of Medicine, Airlangga University, Surabaya,
Indonesia.
(3)Department of Clinical Pharmacy, Faculty of Pharmacy, Airlangga University,
Gubeng, Surabaya, East Java, Indonesia.
Anti-Epileptic Drugs (AEDs) are the main therapy for epilepsy to prevent
seizures. Non-adherence situation plays an important factor in the failure of
seizure control. Such a condition may generate several impacts on clinical,
social, and economic aspect. Several methods are used to measure adherence in
epilepsy patients, including direct and indirect measurement. The direct measure
involves measurement of drug levels in hair or body fluids such as blood and
saliva. Whereas, indirect measure involves the non-biological tools, for example,
a self-report measure, pill counts, appointment attendance, medication refills,
and seizure frequency. Numerous factors may affect adherence in epilepsy
patients, such as age, sex, and seizure aetiology, seizure sites, which are
categorised as irreversible factors and hardly to be improved. However, there are
factors that can be influenced to improve adherence such as patient knowledge,
medication, cultural, health care professionals, and national health policies,
which are related to treatment and education factor which is associated with
behaviour to be likely adherence.
DOI: 10.3889/oamjms.2018.235
PMCID: PMC6026415
PMID: 29983823
du Pon E(1)(2), El Azzati S(1), van Dooren A(1), Kleefstra N(3)(4), Heerdink
E(1)(5), van Dulmen S(6)(7)(8).
Author information:
(1)Research Group Process Innovations in Pharmaceutical Care, Utrecht University
of Applied Sciences, Utrecht, the Netherlands, esther.dupon@hu.nl.
(2)Diabetes Centre, Isala Clinics, Zwolle, the Netherlands, esther.dupon@hu.nl.
(3)Department of Internal Medicine, University Medical Center Groningen,
University of Groningen, Groningen, the Netherlands.
(4)Medical Research Group, Langerhans, Ommen, the Netherlands.
(5)Department of Pharmaceutical Sciences, Utrecht University, Utrecht, the
Netherlands.
(6)NIVEL (Netherlands Institute for Health Services Research), Department of
Communication in Healthcare, Utrecht, the Netherlands.
(7)Radboud University Medical Center, Radboud Institute for Health Sciences,
Department of Primary and Community care, Nijmegen, the Netherlands.
(8)Faculty of Health and Social Sciences, University of Southeast Norway,
Drammen, Norway.
Purpose: The present study aims to investigate the effect of the group-based
Proactive Interdisciplinary Self-Management (PRISMA) training program on
medication adherence in patients with type 2 diabetes (T2DM) treated in primary
care.
Patients and methods: The current study is a two-arm, parallel group, randomized,
open label trial (1:1) of 6-month duration with a 6-month extension period in
which both groups received the intervention (wait-list control). People 18 years
old or older who were diagnosed with T2DM were included. The intervention
consisted of two group meetings about T2DM guided by care providers. The control
group received usual care only (visits at the general practice). The primary
outcome was adherence based on pharmacy refill data and was measured using
medication possession ratio (MPR). The secondary outcomes were the number of drug
holidays and self-reported adherence, measured by the 5-item Medication Adherence
Rating Scale (MARS-5).
Results: Of the total sample (n=108), 66.6% were male. The mean age was 69.3
years (SD=9.1). In the 6-month period, patients were more adherent in the
intervention group (n=56) (median MPR =100.0 [51.1-100.0]) than in the control
group (n=52) (median MPR =97.7 [54.1-100.0]) (U=1,042, z=-2.783, P=0.005). The
intervention group had less drug holidays than the control group (relative risk
0.55, 95% CI, 0.37-0.80). The sum scores of the MARS did not differ between the
intervention group (median =23.98, SD=0.91) and the control group (median =24.00,
SD=1.54).
Conclusion: The PRISMA program resulted in a small improvement in MPR and fewer
drug holidays, while no improvement has been found in self-reported adherence.
However, health care providers and policy makers could take into account that
adherence might be influenced by PRISMA.
DOI: 10.2147/PPA.S188703
PMCID: PMC6512791
PMID: 31190757
Li X(1), Zhang S(2), Xu H(3), Tang X(2), Zhou H(2), Yuan J(2), Wang X(2), Qu
Z(2), Wang F(2), Zhu H(4), Guo S(2), Tian D(2), Zhang W(2).
Author information:
(1)Clinics of Cadre, Department of Outpatient, General Hospital of the People's
Liberation Army (301 Hospital), Beijing, China.
(2)School of Social Development and Public Policy, China Institute of Health,
Beijing Normal University, Beijing, China.
(3)Department of Public Health Sciences, University of Rochester School of
Medicine & Dentistry, Rochester, NY, United States of America.
(4)Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke
University Medical Center, Durham, NC, United States of America.
DOI: 10.1371/journal.pone.0146892
PMCID: PMC4760773
PMID: 26894925 [Indexed for MEDLINE]
Author information:
(1)Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University,
Kuwait. Email: amoneim@hsc.edu.kw.
(2)Department of Pharmacy Practice, Faculty of Pharmacy, Qassim University, Saudi
Arabia.
(3)Department of Clinical Pharmacy, Faculty of Pharmacy, National University,
Khartoum, Sudan.
DOI: 10.5830/CVJA-2017-016
PMCID: PMC5885049
PMID: 28345729 [Indexed for MEDLINE]
Author information:
(1)Center for Health Behavior and Health Education, Center for Diabetes
Translation Research, Division of General Internal Medicine and Public Health,
Vanderbilt University Medical Center, Nashville, TN, USA.
lindsay.mayberry@vanderbilt.edu.
(2), 2525 West End Ave. Suite 370, Nashville, TN, 37203, USA.
lindsay.mayberry@vanderbilt.edu.
(3)Center for Health Behavior and Health Education, Center for Diabetes
Translation Research, Division of General Internal Medicine and Public Health,
Vanderbilt University Medical Center, Nashville, TN, USA.
(4), 2525 West End Ave. Suite 370, Nashville, TN, 37203, USA.
(5), 1215 Twenty-First Ave South, Ste 6000, MCE North Tower, Nashville, TN,
37232-8300, USA.
Suboptimal glycemic control is more common among non-Hispanic Blacks (NHBs) and
Hispanics than non-Hispanic Whites (NHWs). Disparities in the performance of
self-care behaviors may contribute to this. To synthesize knowledge on current
self-care disparities, we reviewed studies from January 2011-March 2016 that
included NHWs, NHBs, and Hispanics with type 2 diabetes in the USA. Self-care
behaviors included diet, exercise, medications, self-monitoring of blood glucose
(SMBG), self-foot exams, and not smoking. Of 1241 articles identified in PubMed,
25 met our inclusion criteria. These studies report consistent disparities in
medication adherence. Surprisingly, we found consistent evidence of no
disparities in exercise and some evidence of reverse disparities: compared to
NHWs, Hispanics had healthier diets and NHBs had more regular SMBG. Consistent
use of validated measures could further inform disparities in diet and exercise.
Additional research is needed to test for disparities in self-foot exams, not
smoking, and diabetes-specific problem solving and coping.
DOI: 10.1007/s11892-016-0796-5
PMCID: PMC5096842
PMID: 27671320 [Indexed for MEDLINE]
Author information:
(1)Department of Psychiatry, Yale University School of Medicine.
(2)Department of Biostatistics, Yale University School of Public Health.
Erratum in
J Consult Clin Psychol. 2015 Aug;83(4):747.
DOI: 10.1037/a0038635
PMCID: PMC4380674
PMID: 25622201 [Indexed for MEDLINE]
1356. BMC Health Serv Res. 2017 Feb 7;17(1):119. doi: 10.1186/s12913-017-2020-y.
Author information:
(1)Division of Pharmacy and Optometry, Manchester Academic Health Sciences
Centre, University of Manchester, Manchester, M13 9PB, UK.
Rachael.Thorneloe@manchester.ac.uk.
(2)Centre for Dermatology Research, Manchester Academic Health Sciences Centre,
University of Manchester, Manchester, UK. Rachael.Thorneloe@manchester.ac.uk.
(3)Centre for Dermatology Research, Manchester Academic Health Sciences Centre,
University of Manchester, Manchester, UK.
(4)Salford Royal NHS Foundation Trust, Salford, UK.
(5)Centre for Pharmacoepidemiology and Drug Safety, Division of Pharmacy and
Optometry, Manchester Academic Health Sciences Centre, University of Manchester,
Manchester, UK.
(6)Division of Musculoskeletal and Dermatological Sciences, Manchester Academic
Health Sciences Centre, University of Manchester, Manchester, UK.
DOI: 10.1186/s12913-017-2020-y
PMCID: PMC5297180
PMID: 28173867 [Indexed for MEDLINE]
1357. J Pharm Health Care Sci. 2019 Jan 22;5:2. doi: 10.1186/s40780-019-0132-8.
eCollection 2019.
Hashimoto K(#)(1), Urata K(#)(1), Yoshida A(1), Horiuchi R(2), Yamaaki N(3), Yagi
K(4), Arai K(1).
Author information:
(1)1Faculty of Pharmacy, Institute of Medical, Pharmaceutical, and Health
Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192 Japan.
(2)Gran Pharma Inc., 1-5-2 Hon-machi, Kanazawa, 920-0853 Japan.
(3)3Department of Internal Medicine, Japan Community Healthcare Organization
Kanazawa Hospital, Ha-15 Oki-machi, Kanazawa, 920-8610 Japan.
(4)4Department of Internal Medicine, Graduate School of Medical Science, Kanazawa
University, 13-1 Takara-machi, Kanazawa, 920-8641 Japan.
(#)Contributed equally
DOI: 10.1186/s40780-019-0132-8
PMCID: PMC6341584
PMID: 30693091
Conflict of interest statement: The study was approved by the each institution’s
ethics committees of Kanazawa University, and Japan Community Healthcare
Organization (JCHO) Kanazawa Hospital.Not applicable.The authors declare that
they have no competing interests.Springer Nature remains neutral with regard to
jurisdictional claims in published maps and institutional affiliations.
Author information:
(1)School of Pharmacy, RCSI, St. Stephen's Green, Dublin 2, Ireland.
pauldillon@rcsi.com.
(2)Primary Care Medicine, Department of General Practice and HRB Centre for
Primary Care Research, RCSI, St. Stephen's Green, Dublin 2, Ireland.
(3)School of Pharmacy, RCSI, St. Stephen's Green, Dublin 2, Ireland.
DOI: 10.1186/s12889-018-6209-8
PMCID: PMC6247632
PMID: 30458754 [Indexed for MEDLINE]
Ryan TP(1), Morrison RD(1), Sutherland JJ(1), Milne SB(1), Ryan KA(1), Daniels
JS(1), Misra-Hebert A(2), Hicks JK(3), Vogan E(4), Teng K(3), Daly TM(5).
Author information:
(1)Sano Laboratories, Sano Informed Prescribing, Franklin, Tennessee, United
States of America.
(2)Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio, United
States of America.
(3)Medicines Department, Cleveland Clinic, Cleveland, Ohio, United States of
America.
(4)Reporting and Analytics, Cleveland Clinic, Cleveland, Ohio, United States of
America.
(5)Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland
Clinic, Cleveland, Ohio, United States of America.
Author information:
(1)Biostatistician, Cerner Population Health Services, Kansas City, MO.
(2)Scientist, Cerner Research Services, Culver City, CA.
(3)Director of Business Intelligence and Analytics, KaMMCO Health Solutions,
Topeka, KS, and Senior Financial Analyst II, Children's Mercy Hospital, Topeka,
KS.
(4)Medical Director, Population Health Services, Cerner Health Connections,
Culver City, CA.
Khayyat SM(1), Khayyat SM(2), Hyat Alhazmi RS(2), Mohamed MM(1)(3), Abdul Hadi
M(4).
Author information:
(1)Department of Clinical Pharmacy, Faculty of Pharmacy, Umm Al-Qura University,
Makkah, Saudi Arabia.
(2)Public Health Centers, Ministry of Health, Makkah, Saudi Arabia.
(3)Pharmaceutical Research Center, Deanship of Scientific Research, Umm Al-Qura
University, Makkah, Saudi Arabia.
(4)School of Healthcare, University of Leeds, Leeds, United Kingdom.
Erratum in
PLoS One. 2017 Oct 31;12 (10 ):e0187614.
DOI: 10.1371/journal.pone.0171255
PMCID: PMC5279800
PMID: 28135324 [Indexed for MEDLINE]
Baker Z(1), Javanbakht M(2), Mierzwa S(3), Pavel C(3), Lally M(4), Zimet G(5),
Gorbach P(2)(6).
Author information:
(1)Department of Epidemiology, University of California Los Angeles, Los Angeles,
CA, USA. zoebaker@ucla.edu.
(2)Department of Epidemiology, University of California Los Angeles, Los Angeles,
CA, USA.
(3)Population Council, New York, NY, USA.
(4)Department of Infectious Diseases, Brown University Warren Alpert Medical
School, Providence, RI, USA.
(5)Department of Pediatrics, Indiana University School of Medicine, Indianapolis,
IN, USA.
(6)Division of Infectious Diseases, David Geffen School of Medicine, University
of California Los Angeles, Los Angeles, CA, USA.
Young men who have sex with men (YMSM) face a disproportionately high burden of
HIV. Oral pre-exposure prophylaxis (PrEP) is effective in preventing HIV
acquisition, but adherence to PrEP among YMSM may be inadequate. Medication
adherence may be assessed via biomarkers, which are expensive and invasive, or
via self-report through Audio Computer Assisted Self-Interview (ACASI), which may
result in over-reporting of adherence. In this paper we assess the potential of a
new method of self-report, the Interactive Questionnaire System (iQS), in validly
estimating true adherence rates. PrEP adherence among 167 YMSM aged 15-23 was
measured via dried blood spot (DBS), ACASI, and iQS twice over a 24-week study
period. Both ACASI- and iQS-reported data revealed that over 40% of individuals
self-reporting adequate PrEP adherence had DBS-estimated drug levels indicating
inadequate adherence. Adjusted logistic repeated measures random intercept
regression analyses indicated that younger YMSM had higher odds of over-reporting
adherence than older YMSM-each 1 year increase in age was associated with 0.79
times the odds of over-reporting adherence (95% CI 0.63, 0.98; p value = 0.031),
and being African American was associated with 3.22 times greater odds of
over-reporting than non-African Americans (95% CI 1.51, 6.90; p-value = 0.0003).
These results suggest that ACASI and iQS methods of self-report significantly
overestimate true PrEP adherence rates among YMSM, and that the odds of
over-reporting adherence may be affected by both age and race.
DOI: 10.1007/s10461-017-1958-4
PMCID: PMC6038811
PMID: 29079950 [Indexed for MEDLINE]
Modi A(1), Sen S(2), Adachi JD(3), Adami S(4), Cortet B(5), Cooper AL(6), Geusens
P(7), Mellström D(8), Weaver JP(2), van den Bergh JP(7)(9), Keown P(10), Sajjan
S(2).
Author information:
(1)Center for Observational and Real-World Evidence (CORE), Merck & Co., Inc.,
600 Corporate Drive, Mailstop: CRB-205, Kenilworth, NJ, 07033, USA.
ankita.modi@merck.com.
(2)Center for Observational and Real-World Evidence (CORE), Merck & Co., Inc.,
600 Corporate Drive, Mailstop: CRB-205, Kenilworth, NJ, 07033, USA.
(3)St Joseph's Healthcare and McMaster University, Hamilton, ON, Canada.
(4)Department of Medicine, University of Verona, Verona, Italy.
(5)Department of Rheumatology, University Hospital of Lille, Lille Cedex, France.
(6)Bridge Medical Center, Crawley, West Sussex, UK.
(7)Department of Rheumatology, Maastricht University Medical Center, Maastricht,
The Netherlands.
(8)Department of Internal Medicine and Geriatrics, Gothenburg University,
Gothenburg, Sweden.
(9)Department of Internal Medicine, VieCuri Medical Center, Venlo, The
Netherlands.
(10)Syreon Corporation, Vancouver, Canada.
DOI: 10.1007/s00198-017-4271-1
PMCID: PMC5818582
PMID: 29110061 [Indexed for MEDLINE]
Author information:
(1)Clinical Pharmacy Department, Bisha Health Affairs, Ministry of Health, Bisha,
Saudi Arabia, abuayed.alq@gmail.com.
(2)Department of Pharmacy and Allied Sciences, Riyadh Elm University, Riyadh,
Saudi Arabia, abuayed.alq@gmail.com.
(3)Department of Rehabilitation Sciences, College of Applied Medical Sciences,
King Saud University, Riyadh, Saudi Arabia.
(4)Department of Physical Therapy, King Abdullah Hospital, Bisha Health Affairs,
Ministry of Health, Bisha, Saudi Arabia.
Erratum in
Patient Prefer Adherence. 2019 Feb 08;13:249.
DOI: 10.2147/PPA.S176355
PMCID: PMC6309134
PMID: 30636871
Degree of Planning of Sexual Intercourse Among Men From China, Japan, and Taiwan
Taking Medication for Erectile Dysfunction: Findings of an Observational,
Cross-Sectional Survey.
Jiann BP(1), Nakajima K(2), Dighe S(3), Harshman-Smith CD(4), Hassan TA(3).
Author information:
(1)Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung and
School of Medicine, National Yang-Ming Medical University, Taipei City, Taiwan.
Electronic address: bpjiann@gmail.com.
(2)Department of Urology, Faculty of Medicine, Toho University, Tokyo, Japan.
(3)Pfizer Inc, New York, NY, USA.
(4)ZS Associates, Inc (a strategic consulting partner to Pfizer), New York, NY,
USA.
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.esxm.2018.10.006
PMCID: PMC6377368
PMID: 30522975
Shallcross AJ(1), Becker DA(2), Singh A(2), Friedman D(2), Jurd R(2), French
JA(2), Devinsky O(2), Spruill TM(3).
Author information:
(1)Department of Population Health, New York University, School of Medicine, USA.
Electronic address: Amanda.shallcross@nyumc.org.
(2)Department of Neurology, New York University, School of Medicine, USA.
(3)Department of Population Health, New York University, School of Medicine, USA.
DOI: 10.1016/j.yebeh.2015.01.034
PMCID: PMC4701194
PMID: 25847430 [Indexed for MEDLINE]
Self-reported adherence and pharmacy refill adherence are both predictive for an
undetectable viral load among HIV-infected migrants receiving cART.
Been SK(1), Yildiz E(1)(2), Nieuwkerk PT(3), Pogány K(4), van de Vijver DAMC(5),
Verbon A(1)(2).
Author information:
(1)Department of Internal Medicine, division of Infectious Diseases, Erasmus
University Medical Center, Rotterdam, The Netherlands.
(2)Department of Medical Microbiology and Infectious Diseases, Erasmus University
Medical Center, Rotterdam, The Netherlands.
(3)Department of Medical Psychology, Academic Medical Center, Amsterdam, The
Netherlands.
(4)Department of Internal Medicine, Maasstad Hospital, Rotterdam, The
Netherlands.
(5)Viroscience department, Erasmus University Medical Center, Rotterdam, The
Netherlands.
HIV-infected migrants were shown to have poorer treatment outcomes than Dutch
HIV-infected patients, often due to worse treatment adherence. Self-reported
adherence would be an easy way to monitor adherence, but its validity relative to
pharmacy refill adherence has not been extensively evaluated in migrants. All
HIV-infected migrants older than 18 years and in care at the two Rotterdam
HIV-treatment centers were eligible. Refill data with leftover medication (PRL)
(residual pill count) were obtained from their pharmacies up to 15 months prior
to inclusion. Self-reported adherence to combination Antiretroviral Therapy was
assessed by four questions about adherence at inclusion. Additionally, risk
factors for pharmacy refill non-adherence were examined. In total, 299
HIV-infected migrants were included. Viral load (VL) was detectable in 11% of the
patients. Specificity of PRL was 53% for patients with an adherence of 100% and
decreased with lower cut-off values. Sensitivity and negative predictive value
(NPV) were 68% and 15% and increased with lower cut-off values. Positive
predictive value (PPV) was around 93% for all cut-off values. Using the
self-reported questions, 139 patients (47%) reported to be adherent. Sensitivity
was 49% and specificity was 72%. PPV and NPV were 95% and 13%. No risk factors
for pharmacy refill non-adherence were found in multivariable analyses. Both PRL
and self-reported adherence, can predict undetectable VL in HIV-infected
migrants. PPV and NPV are similar for both methods. This study shows that using
four self-reported items is sufficient to predict adherence which is crucial for
optimal clinical outcome in HIV-infected migrants.
DOI: 10.1371/journal.pone.0186912
PMCID: PMC5679639
PMID: 29121665 [Indexed for MEDLINE]
Salvatore AL(1), Ahn S(2)(3), Jiang L(4), Lorig K(5), Ory MG(3).
Author information:
(1)College of Public Health, University of Oklahoma Health Sciences Center,
Oklahoma City, OK, USA.
(2)Division of Health Systems Management and Policy, The University of Memphis,
School of Public Health, Memphis, TN, USA.
(3)Department of Health Promotion and Community Health Sciences, Texas A&M Health
Science Center, School of Rural Public Health, College Station, TX, USA.
(4)Department of Epidemiology, University of California Irvine, Irvine, CA, USA.
(5)Department of Medicine, Stanford University, Stanford, CA, USA.
OBJECTIVE: This study examined the applicability of the Stanford Chronic Disease
Self-Management Program (CDSMP) for cancer survivors and compared outcomes among
cancer survivors and participants with other chronic diseases (non-cancer
survivors).
METHODS: Participants were older adults (n = 1170) enrolled in the National Study
of CDSMP. Detailed information about physical and psychosocial health status and
health and healthcare behaviors was collected from participants (n = 116 cancer
survivors and n = 1054 non-cancer survivors) via self-report before CDSMP
participation and at 6-month and 12-month follow-ups. Linear and generalized
linear mixed models were used to assess baseline-to-6-month and
baseline-to-12-month changes.
RESULTS: Among cancer survivors, general health, depression, and sleep
significantly improved from baseline to 6 months. These significant changes were
sustained at 12 months. Communication with physician, medication compliance,
pain, days in poor physical health, days in poor mental health, and days kept
from usual activities and physical activity also improved significantly from
baseline to 12 months. Among non-cancer survivors, all outcomes except medication
compliance and stress improved significantly from baseline to 6 months. At 12
months, medication compliance also improved significantly.
CONCLUSIONS: Findings suggest that participation in CDSMP, an evidence-based
chronic disease self-management intervention not specifically tailored for cancer
survivorship, may significantly improve physical and psychosocial health status
and key health and healthcare behaviors among cancer survivors. Additional
research is needed to elucidate cancer survivors' unique needs and examine the
benefits of tailored versions of CDSMP. Nevertheless, CDSMP, available at scale
nationally and internationally, is a promising intervention for cancer survivors
and should be considered a valuable component of survivorship care.
DOI: 10.1002/pon.3783
PMID: 25871889 [Indexed for MEDLINE]
Author information:
(1)Student Research Center, School of Nursing and Midwifery, Isfahan University
of Medical Sciences, Isfahan, Iran.
(2)Department of Critical Care Nursing, Kidney Diseases Research Center, Faculty
of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
(3)Ulcer Repair Research Center, School of Nursing and Midwifery, Isfahan
University of Medical Sciences, Isfahan, Iran.
DOI: 10.4103/ijnmr.IJNMR_220_15
PMCID: PMC5443003
PMID: 28584545
Author information:
(1)Internal Medicine Department, Universidade Federal do Rio Grande do Sul, Rua
Ramiro Barcellos, 2350, Porto Alegre, CEP 90035-903 Brazil.
(2)Internal Medicine Department, Universidade Federal do Rio Grande do Sul, Rua
Ramiro Barcellos, 2350, Porto Alegre, CEP 90035-903 Brazil ; Endocrine Division,
Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
DOI: 10.1186/s13098-016-0162-4
PMCID: PMC4966590
PMID: 27478510
1371. Diabetes Technol Ther. 2016 Oct;18(10):644-649. Epub 2016 Aug 19.
Author information:
(1)1 Department of Medicine, Center for Health Disparities Research, Medical
University of South Carolina , Charleston, South Carolina.
(2)2 Division of General Internal Medicine and Geriatrics, Department of
Medicine, Medical University of South Carolina , Charleston, South Carolina.
(3)3 Health Equity and Rural Outreach Innovation Center (HEROIC), Ralph H.
Johnson Department of Veterans Affairs Medical Center , Charleston, South
Carolina.
(4)4 Center for Surgery and Public Health , Brigham and Women's Hospital, Boston,
Massachusetts.
DOI: 10.1089/dia.2016.0079
PMCID: PMC5069713
PMID: 27541872 [Indexed for MEDLINE]
Krack G(1)(2), Holle R(3), Kirchberger I(4)(5)(6), Kuch B(7), Amann U(4)(5)(6),
Seidl H(3).
Author information:
(1)Munich Center of Health Sciences (MC-Health), Institute for Health Economics
and Management, Ludwig-Maximilians-Universität München, Ludwigstr. 28 RG, 80539,
Munich, Germany. krack@bwl.lmu.de.
(2)Helmholtz Zentrum München, Institute of Health Economics and Health Care
Management, Neuherberg, Germany. krack@bwl.lmu.de.
(3)Helmholtz Zentrum München, Institute of Health Economics and Health Care
Management, Neuherberg, Germany.
(4)UNIKA-T Augsburg, Chair of Epidemiology, Ludwig-Maximilians Universität
München, Augsburg, Germany.
(5)Helmholtz Zentrum München, Institute of Epidemiology II, Neuherberg, Germany.
(6)Central Hospital of Augsburg, MONICA/KORA Myocardial Infarction Registry,
Augsburg, Germany.
(7)Hospital of Nördlingen, Department of Internal Medicine/Cardiology,
Nördlingen, Germany.
DOI: 10.1186/s12877-018-0827-y
PMCID: PMC6001009
PMID: 29898677 [Indexed for MEDLINE]
Kruger J(1)(2), O'Halloran A(3), Rosenthal AC(4), Babb SD(5), Fiore MC(6).
Author information:
(1)Office on Smoking and Health, Centers for Disease Control and Prevention,
National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA,
30341, USA. Ezk0@cdc.gov.
(2)Office on Smoking and Health, Centers for Disease Control and Prevention, 4770
Buford Highway, N.E., F-79, Atlanta, GA, 30341-3724, USA. Ezk0@cdc.gov.
(3)Contractor (NGIS) for Office on Smoking and Health, National Center for
Chronic Disease Prevention, Atlanta, GA, 30341, USA.
(4)Health Systems Consulting, Atlanta, GA, 30341, USA.
(5)Office on Smoking and Health, Centers for Disease Control and Prevention,
National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA,
30341, USA.
(6)Center for Tobacco Research and Intervention, University of Wisconsin School
of Medicine and Public Health, Madison, WI, 53711, USA.
DOI: 10.1186/s12889-016-2798-2
PMCID: PMC4751655
PMID: 26868930 [Indexed for MEDLINE]
Moreno G(1), Lin EH(2), Chang E(2), Johnson RL(2), Berthoud H(2), Solomon CC(3),
Morales LS(2)(4).
Author information:
(1)UCLA Department of Family Medicine, David Geffen School of Medicine at UCLA,
10880 Wilshire Blvd., Suite 1800, Los Angeles, CA, 90024, USA.
gemoreno@mednet.ucla.edu.
(2)Group Health Research Institute, Seattle, WA, USA.
(3)School of Social Work, University of Washington, Seattle, WA, USA.
(4)Center for Health Equity, Diversity and Inclusion, School of Medicine,
University of Washington School Medicine, Seattle, WA, USA.
Comment in
J Gen Intern Med. 2016 Mar;31(3):322.
DOI: 10.1007/s11606-015-3500-6
PMCID: PMC4762820 [Available on 2017-03-01]
PMID: 26311200 [Indexed for MEDLINE]
Author information:
(1)Indiana University School of Nursing, Indianapolis, IN, USA
hullmann@iupui.edu.
(2)University of Pennsylvania, Philadelphia, PA, USA.
(3)University of Pennsylvania, Philadelphia, PA, USA The Children's Hospital of
Philadelphia, Philadelphia, PA, USA.
The current study examined adherence to medication regimens among adolescents
with cancer by applying the Pediatric Self-Management Model. Adolescents and
their parents reported on adherence to medication, reasons for nonadherence, and
patient-, family-, and community-level psychosocial variables. Adolescent- and
parent-reported adherence were significantly correlated, with about half of the
sample reporting perfect adherence. The majority reported "just forgot" as the
most common reason for missed medication. Patient-, family-, and community-level
variables were examined as predictors of adherence. With regard to individual
factors, adolescents who endorsed perfect adherence reported a greater proportion
of future-orientated goals and spent fewer days in outpatient clinic visits. For
family factors, adolescents who endorsed perfect adherence reported greater
social support from their family and were more likely to have a second caregiver
who they perceived as overprotective. The community-level variable (social
support from friends) tested did not emerge as a predictor of adherence. The
results of this study provide direction for intervention efforts to target
adolescent goals and family support in order to increase adolescent adherence to
cancer treatment regimens.
DOI: 10.1177/1043454214553707
PMCID: PMC4410359
PMID: 25366574 [Indexed for MEDLINE]
Hunt CW(1).
Author information:
(1)Caralise W Hunt, School of Nursing, Auburn University, Auburn, AL 36849,
United States.
DOI: 10.4239/wjd.v6.i2.225
PMCID: PMC4360416
PMID: 25789104
Author information:
(1)Unidad de Alergia, Asma e Inmunología Clínica, Buenos Aires, Argentina.
E-mail: elomalbran@hotmail.com.
(2)Asociación Argentina de Pacientes con Angioedema Hereditario, Buenos Aires,
Argentina.
(3)Unidad de Alergia, Asma e Inmunología Clínica, Buenos Aires, Argentina.
The benefits of the worldwide approval of new drugs for the treatment of acute
C1-INH-HAE attacks may still not reach all patients. Identifying the current
barriers in the access to medication, as well as conducting a detailed assessment
of the progress in this area, is essential to achieve universal treatment. Two
hundred and twenty five patients registered in the Argentina Hereditary
Angioedema Patient Association (AHAEPA) were randomly selected and invited to
participate in a web based questionnaire on accessibility to icatibant and
pdC1-INH, self-treatment, delay to treatment, and coverage. The data retrieved
was compared to our previous reports in 2008 and 2013. We collected 156/225
answers. One hundred and eighteen (76%) patients have either pdC1-INH (n = 86),
icatibant (n = 10) or both (n = 22), while 38 (24%) do not have access to
treatment. In 2008, 26% had access while 82% had it in 2013. Thirty-two subjects
(22%) self-inject themselves, similar to 29% in 2013, even though between
studies, widespread self-injection training activities have taken place. However,
considering injections by proxy, home treatment reached 56%. Only half of the
patients decide to receive treatment early during the attack. Ninety-nine
patients (63%) have full coverage, thirty (19%) have no coverage at all and the
rest only obtain partial reimbursement. Twenty-nine families (31%) share a single
treatment dose of the medication, better than 36% in 2013. Argentina's C1-INH-HAE
patients had a sustained improvement in their access to medication. Efforts
should continue to further improve accessibility and optimal management of HAE
acute attacks to all patients in the country.
Corden ME(1), Koucky EM(1), Brenner C(1), Palac HL(1), Soren A(2), Begale M(1),
Ruo B(3), Kaiser SM(1), Duffecy J(4), Mohr DC(1).
Author information:
(1)Center for Behavioral Intervention Technologies, Department of Preventative
Medicine, Northwestern University, USA.
(2)Department of Design and Environmental Analysis, Cornell University, USA.
(3)Division of General Internal Medicine and Geriatrics, Department of Medicine,
Northwestern University, USA.
(4)Department of Psychiatry, University of Illinois, USA.
DOI: 10.1177/2055207616663069
PMCID: PMC6001228
PMID: 29942564
Inverse probability weighting and doubly robust methods in correcting the effects
of non-response in the reimbursed medication and self-reported turnout estimates
in the ATH survey.
Author information:
(1)Department of Health, Functional Capacity and Welfare National Institute for
Health and Welfare (THL), P,O, Box 30, FI-00271 Helsinki, Finland.
tommi.harkanen@thl.fi.
DOI: 10.1186/1471-2458-14-1150
PMCID: PMC4246429
PMID: 25373328 [Indexed for MEDLINE]
Author information:
(1)Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University
Hospital, Uppsala, Sweden.
(2)Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University
Hospital, Uppsala, Sweden. lisa.ekselius@neuro.uu.se.
There are very few studies on the long-term outcome in subjects diagnosed with
ADHD as adults. The objective of the present study was to assess this and relate
the outcome to whether there was current medication or not and to other potential
predictors of favourable outcome. A prospective clinical cohort of adults
diagnosed with ADHD according to DSM-IV criteria was followed-up on an average of
6 years after first evaluation (n = 124; mean age 42 years, 51% males). ADHD
symptom trajectories were assessed as well as medication, global functioning,
disability, health-related quality of life, and alcohol and drug consumption at
follow-up. Ninety percent of those diagnosed were initially treated
pharmacologically and half of them discontinued treatment. One-third reported
remission, defined as not fulfilling any ADHD subtype and a GAF-value last year
≥ 70, which was not affected by comorbidity at baseline. Current medication was
not associated with remission. Subjects evaluated and first diagnosed with ADHD
as adults are functionally improved at follow-up 6 years later despite a high
percentage of psychiatric comorbidity at baseline. Half dropped out of
medication, and there was no difference in ADHD remission between subjects with
on-going medication at follow-up or subjects without medication, although current
medication was related to a higher degree of self-reported global improvement.
DOI: 10.1007/s00406-017-0850-6
PMCID: PMC5956008
PMID: 29143159 [Indexed for MEDLINE]
Author information:
(1)Department of Social and Preventive Medicine, Faculty of Medicine, University
of Malaya, Malaysia ; Ministry of Health, Malaysia.
(2)Department of Social and Preventive Medicine, Faculty of Medicine, University
of Malaya, Malaysia ; Centre for Population Health, Faculty of Medicine,
University of Malaya, Malaysia.
INTRODUCTION: The aim of this study was to assess the reliability and validity of
a modified Malaysian version of the Medication Adherence Reasons Scale
(MAR-Scale).
METHODS: In this cross-sectional study, the 15-item MAR-Scale was administered to
665 patients with hypertension who attended one of the four government primary
healthcare clinics in the Hulu Langat and Klang districts of Selangor, Malaysia,
between early December 2012 and end-March 2013. The construct validity was
examined in two phases. Phase I consisted of translation of the MAR-Scale from
English to Malay, a content validity check by an expert panel, a face validity
check via a small preliminary test among patients with hypertension, and
exploratory factor analysis (EFA). Phase II involved internal consistency
reliability calculations and confirmatory factor analysis (CFA).
RESULTS: EFA verified five existing factors that were previously identified (i.e.
issues with medication management, multiple medications, belief in medication,
medication availability, and the patient's forgetfulness and convenience), while
CFA extracted four factors (medication availability issues were not extracted).
The final modified MAR-Scale model, which had 11 items and a four-factor
structure, provided good evidence of convergent and discriminant validities.
Cronbach's alpha coefficient was > 0.7, indicating good internal consistency of
the items in the construct. The results suggest that the modified MAR-Scale has
good internal consistencies and construct validity.
CONCLUSION: The validated modified MAR-Scale (Malaysian version) was found to be
suitable for use among patients with hypertension receiving treatment in primary
healthcare settings. However, the comprehensive measurement of other factors that
can also lead to non-adherence requires further exploration.
DOI: 10.11622/smedj.2015069
PMCID: PMC4545136
PMID: 25902719 [Indexed for MEDLINE]
1382. MMWR Morb Mortal Wkly Rep. 2018 Apr 20;67(15):437-442. doi:
10.15585/mmwr.mm6715a1.
Active Epilepsy and Seizure Control in Adults - United States, 2013 and 2015.
DOI: 10.15585/mmwr.mm6715a1
PMCID: PMC6191103
PMID: 29672474 [Indexed for MEDLINE]
Author information:
(1)University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin.
(2)University of Wisconsin-Madison, Madison, Wisconsin.
DOI: 10.5688/ajpe80116
PMCID: PMC4776294
PMID: 26941442 [Indexed for MEDLINE]
1384. Front Psychiatry. 2015 Nov 25;6:167. doi: 10.3389/fpsyt.2015.00167.
eCollection
2015.
Coelho LF(1), Barbosa DL(1), Rizzutti S(1), Muszkat M(1), Bueno OF(1), Miranda
MC(1).
Author information:
(1)Psychobiology Department, Universidade Federal de São Paulo , São Paulo ,
Brazil.
DOI: 10.3389/fpsyt.2015.00167
PMCID: PMC4659172
PMID: 26635642
Graumlich JF(1), Wang H(2), Madison A(3), Wolf MS(4), Kaiser D(5), Dahal K(6),
Morrow DG(7).
Author information:
(1)Department of Medicine, University of Illinois College of Medicine at Peoria,
530 Northeast Glen Oak Avenue, Peoria, IL 61637, USA.
(2)Department of Medicine, Division of Research Services, University of Illinois
College of Medicine at Peoria, One Illini Drive, Peoria, IL 61605, USA.
(3)Department of Psychology, University of Illinois at Urbana-Champaign, 603 E.
Daniel, Champaign, IL 61820, USA.
(4)Division of General Internal Medicine and Geriatrics, Department of Medicine,
Northwestern University Feinberg School of Medicine, 750 North Lake Shore Drive,
10th Floor, Chicago, IL 60611, USA.
(5)Northwestern Medical Faculty Foundation, 675 North Saint Clair Street,
Chicago, IL 60611, USA.
(6)Department of Medicine, University of Illinois College of Medicine at Peoria,
One Illini Drive, Peoria, IL 61605, USA.
(7)Department of Educational Psychology, University of Illinois at
Urbana-Champaign, Education Building, 1310 South 6th Street, Champaign, IL 61820,
USA.
DOI: 10.1155/2016/2129838
PMCID: PMC5028848
PMID: 27699179 [Indexed for MEDLINE]
Author information:
(1)Department of Psychology, Rosalind Franklin University of Medicine and
Science, North Chicago, IL.
(2)Department of Gastroenterology, Boston Children's Hospital, Harvard Medical
School, Boston, MA, USA.
DOI: 10.2147/CEG.S106302
PMCID: PMC5003515
PMID: 27601930
Migration, Health Care Behaviors, and Primary Care for Rural Latinos with
Diabetes.
Moreno G(1), Morales LS(2), Batts F(3), Noguera C(4), Isiordia M(5), Mangione
CM(6)(7).
Author information:
(1)Department of Family Medicine, David Geffen School of Medicine at UCLA, 10880
Wilshire Blvd, Suite 1800, Los Angeles, CA, 90024, USA. gemoreno@mednet.ucla.edu.
(2)School of Medicine, University of Washington, Seattle, WA, USA.
(3)Livingston Health Centers, Inc., Livingston, CA, USA.
(4)Community Health Centers, Inc., Stockton, CA, USA.
(5)University of California Davis, Davis, CA, USA.
(6)Division of Health Services Research and General Internal Medicine, David
Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
(7)Department of Health Policy and Management, UCLA Fielding School of Public
Health, Los Angeles, CA, USA.
Many US Latinos migrate or travel between the US and Mexico on a regular basis,
defined as circular migration. Latinos with diabetes (n = 250) were surveyed
about circular migration and their ability to use medications and perform
recommended diabetes self-care activities. A review of medical charts was
performed. Twenty-eight percent (n = 70) of patients traveled to Mexico during
the last 12 months. Older Latinos were more likely to report traveling to Mexico
and back into the US. Among those that traveled, 29 % reported use of less
medication than they wanted to or were prescribed because of travel and 20 % ran
out of medications. The rate of reported problem areas while traveling were 39 %
(27/70) for following a diabetic diet, 31 % (21/70) for taking medication, and
37 % (26/70) for glucose self-monitoring. The results suggest that the structure
of primary care and care coordination are important for this population to fully
engage in diabetes self-care.
DOI: 10.1007/s10903-015-0254-5
PMCID: PMC4721941
PMID: 26195289 [Indexed for MEDLINE]
Bourbeau J(1)(2), Farias R(1), Li PZ(1), Gauthier G(2), Battisti L(2)(3), Chabot
V(2), Beauchesne MF(4), Villeneuve D(2), Côté P(2), Boulet LP(5).
Author information:
(1)1 Respiratory Epidemiology and Clinical Research Unit (RECRU), Research
Institute of the McGill University Health Centre (RI-MUHC), Montreal, Québec,
Canada.
(2)2 Quebec Respiratory Health Education Network/Réseau Québécois d'Éducation en
Santé Respiratoire (QRHEN/RQESR), Québec, Canada.
(3)3 Hôpital St-François d'Assise, Québec, Canada.
(4)4 Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Québec, Canada.
(5)5 Institut Universitaire de Cardiologie et de Pneumologie de Québec,
Université Laval, Québec, Canada.
DOI: 10.1177/1479972317723237
PMCID: PMC5958467
PMID: 28750556 [Indexed for MEDLINE]
Carr MJ(1), Ashcroft DM(2), Kontopantelis E(3), While D(4), Awenat Y(5), Cooper
J(4), Chew-Graham C(6), Kapur N(7), Webb RT(4).
Author information:
(1)Centre for Mental Health and Safety, Institute of Brain, Behaviour and Mental
Health, University of Manchester, UK. Electronic address:
matthew.carr@manchester.ac.uk.
(2)Centre for Pharmacoepidemiology and Drug Safety, Manchester Pharmacy School,
University of Manchester, UK; NIHR Greater Manchester Primary Care Patient Safety
Translational Research Centre, UK.
(3)Centre for Health Informatics, Institute of Population Health, University of
Manchester, UK; NIHR School for Primary Care Research, University of Manchester,
UK.
(4)Centre for Mental Health and Safety, Institute of Brain, Behaviour and Mental
Health, University of Manchester, UK.
(5)School of Psychological Sciences, University of Manchester, UK.
(6)Research Institute of Primary Care and Health Sciences, Keele University, UK.
(7)Centre for Mental Health and Safety, Institute of Brain, Behaviour and Mental
Health, University of Manchester, UK; Manchester Mental Health and Social Care
Trust, UK.
DOI: 10.1016/j.jad.2016.03.013
PMCID: PMC4870375
PMID: 26994436 [Indexed for MEDLINE]
1390. NPJ Prim Care Respir Med. 2017 Nov 14;27(1):61. doi: 10.1038/s41533-017-0061-
7.
Chapman S(1), Dale P(2)(3), Svedsater H(2), Stynes G(2)(4), Vyas N(5), Price
D(6), Horne R(7).
Author information:
(1)University of Bath, Bath, UK.
(2)GSK, Brentford, UK.
(3)Peter Dale, HEOR Solutions Ltd, Marlow, UK.
(4)Gillian Stynes, Bristol-Myers Squibb, Uxbridge, UK.
(5)Healthcare Research Worldwide, Wallingford Oxon, UK.
(6)Observational and Pragmatic Research Institute, Singapore, Singapore.
(7)University College London, London, UK. r.horne@ucl.ac.uk.
People with asthma who do not adhere to their maintenance medication may
experience poorer asthma control and need more healthcare support than those who
adhere. People (N = 1010) aged 18-55 years with self-reported asthma, taking one
or more asthma maintenance medication(s), from five European countries,
participated in a survey using validated scales (Medication Adherence Report
Scale [MARS], Asthma Control Test™ [ACT], Beliefs about Medicine Questionnaire
[BMQ] and the Asthma Treatment Intrusiveness Questionnaire [ATIQ]). We performed
a post hoc evaluation of adherence to maintenance medication, asthma control,
beliefs about medication, preferences for once-daily vs. twice-daily asthma
maintenance medication and treatment intrusiveness, using structural equation
modelling to investigate the relationships between these factors. Most
participants reported potential problems with asthma control (ACT < 19: 76.8%
[n = 776]), low adherence (median MARS = 3.40) and preferred once-daily
medication (73.5% [n = 742/1010]). Non-adherence was associated with worse asthma
control (r = 0.262 [P < 0.001]) and a expressed preference for once-daily
medication over a "twice daily medication that works slightly better" (test
statistic [T] = 2.970 [P = 0.003]). Participants reporting
non-adherence/preferring once-daily medication had negative beliefs about their
treatment (BMQ necessity-concerns differential: r = 0.437 [P < 0.001]/T = 6.886
[P < 0.001]) and found medication intrusive (ATIQ: r = -0.422
[P < 0.001]/T = 2.689[P = 0.007]). Structural equation modelling showed complex
relationships between variables, including: (1) high concerns about treatment
associated with increased perceived treatment intrusiveness and reduced
adherence, which influenced asthma control; (2) high concerns about treatment and
healthcare seeking behaviour, which were predictive of preferring twice-daily
asthma medication. Concerns about medication and perceived treatment
intrusiveness were predictive of poor adherence, and were associated with
preference for once-daily asthma medication. Confirm the utility of the PAPA
model and NCF in explaining nonadherence linked to poor asthma control.
DOI: 10.1038/s41533-017-0061-7
PMCID: PMC5686129
PMID: 29138431 [Indexed for MEDLINE]
Ridsdale L(1), McKinlay A(1), Wojewodka G(1), Robinson EJ(2), Mosweu I(3), Feehan
SJ(1), Noble AJ(4), Morgan M(5), Taylor SJ(6), McCrone P(3), Landau S(2),
Richardson M(1), Baker G(7), Goldstein LH(8).
Author information:
(1)Department of Basic and Clinical Neurosciences, Institute of Psychiatry,
Psychology and Neuroscience, King's College London, London, UK.
(2)Department of Biostatistics and Health Informatics, Institute of Psychiatry,
Psychology and Neuroscience, King's College London, London, UK.
(3)King's Health Economics, Institute of Psychiatry, Psychology and Neuroscience,
King's College London, London, UK.
(4)Department of Psychological Sciences, Institute of Psychology, Health and
Society, University of Liverpool, Liverpool, UK.
(5)Institute of Pharmaceutical Science, King's College London, London, UK.
(6)Barts and The London School of Medicine and Dentistry, Queen Mary University
of London, Centre for Primary Care and Public Health, London, UK.
(7)Department of Molecular and Clinical Pharmacology, University of Liverpool,
Liverpool, UK.
(8)Department of Psychology, Institute of Psychiatry, Psychology and
Neuroscience, King's College London, London, UK.
DOI: 10.3310/hta22210
PMCID: PMC5949577
PMID: 29717699 [Indexed for MEDLINE]
Harper SL(1), Edge VL(2)(3), Ford J(4), Thomas MK(2)(5), Pearl D(2), Shirley
J(6); IHACC; RICG, McEwen SA(2).
Author information:
(1)Department of Population Medicine, University of Guelph, Guelph, Ontario,
Canada; harpers@uoguelph.ca.
(2)Department of Population Medicine, University of Guelph, Guelph, Ontario,
Canada.
(3)Office of Public Health Practice, Public Health Agency of Canada, Guelph,
Ontario, Canada.
(4)Department of Geography, McGill University, Montreal, Quebec, Canada.
(5)Centre for Food-borne, Environmental & Zoonotic Infectious Diseases, Public
Health Agency of Canada, Guelph, Ontario, Canada.
(6)Nunavut Research Institute, Iqaluit, Nunavut, Canada.
DOI: 10.3402/ijch.v74.26290
PMCID: PMC4441732
PMID: 26001982 [Indexed for MEDLINE]
Author information:
(1)Department of Family Medicine, University of Michigan, 1018 Fuller Street, Ann
Arbor, MI, 48104-1213, USA, aikensj@umich.edu.
DOI: 10.1007/s11606-015-3208-7
PMCID: PMC4441673
PMID: 25666218 [Indexed for MEDLINE]
Author information:
(1)Department of Drug Dependence Research, National Center of Neurology and
Psychiatry, Tokyo, Japan.
© 2014 The Authors. Psychiatry and Clinical Neurosciences © 2014 Japanese Society
of Psychiatry and Neurology.
DOI: 10.1111/pcn.12232
PMID: 25112197 [Indexed for MEDLINE]
1395. Public Health Res Pract. 2015 Mar 30;25(2):e2521518. doi:
10.17061/phrp2521518.
Gnjidic D(1), Pearson SA(2), Hilmer SN(3), Basilakis J(4), Schaffer AL(5), Blyth
FM(6), Banks E(7); High Risk Prescribing Investigators.
Author information:
(1)Faculty of Pharmacy, University of Sydney, NSW, Australia; Sydney Medical
School, University of Sydney, NSW, Australia danijela.gnjidic@sydney.edu.au.
(2)Faculty of Pharmacy, University of Sydney, NSW, Australia; Sydney School of
Public Health, University of Sydney, NSW, Australia.
(3)Sydney Medical School, University of Sydney, NSW, Australia; Royal North Shore
Hospital and Kolling Institute of Medical Research, Sydney, NSW, Australia.
(4)School of Computing, Engineering and Mathematics, University of Western
Sydney, NSW, Australia.
(5)Faculty of Pharmacy, University of Sydney, NSW, Australia.
(6)Sydney Medical School, University of Sydney, NSW, Australia; Centre for
Education and Research on Ageing (CERA), Concord Hospital, Sydney, NSW,
Australia; Sax Institute, Sydney, NSW, Australia.
(7)Sax Institute, Sydney, NSW, Australia; National Centre for Epidemiology and
Population Health, Australian National University, Canberra, ACT, on behalf of
the High Risk Prescribing Investigators.
DOI: 10.17061/phrp2521518
PMID: 25848736 [Indexed for MEDLINE]
Author information:
(1)Department of Public Health, University of Helsinki, Helsinki, Finland.
tiina.loponen@helsinki.fi.
(2)Department of Public Health, University of Helsinki, Helsinki, Finland.
tea.lallukka@ttl.fi.
(3)Centre of Expertise for Health and Work Ability & Disability Prevention
Research Centre, Finnish Institute of Occupational Health, Helsinki, Finland.
tea.lallukka@ttl.fi.
(4)Department of Public Health, University of Helsinki, Helsinki, Finland.
ansku.holstila@helsinki.fi.
(5)Department of Public Health, University of Helsinki, Helsinki, Finland.
jouni.mm.lahti@helsinki.fi.
BACKGROUND: Physical activity level and overweight have shown associations with
mental health problems but it is not known whether the risk of mental health
problems due to overweight varies by physical activity. We examined joint
association of physical activity and overweight with subsequent psychotropic
medication among 40-60-year-old employees.
METHODS: The questionnaire survey data were derived from Helsinki Health Study
baseline postal questionnaires in 2000-02 among employees of the City of Helsinki
aged 40-60 years (n = 8960, response rate 67%). Baseline survey data were linked
with prospective register data on prescribed psychotropic medication (ATC-codes
N05 and N06, except N06D) among those with written consent (74%) for such
linkage. The analyses included 6169 responders (78% women, corresponding to the
target population). We divided participants into six groups according to their
baseline self-reported body mass index and leisure-time physical activity using
physically highly active normal-weight participants as a reference group. We used
Cox regression analysis adjusted for age, gender, psychotropic medication prior
to baseline, and socioeconomic position, marital status, working conditions,
limiting long-standing illness, alcohol use, and smoking.
RESULTS: At baseline, 49% were overweight and 23% were physically inactive. After
adjusting for age and gender, inactive normal-weight (hazard ratio (HR) 1.3, 95%
CI 1.1-1.5), moderately active overweight (HR 1.3, 95% CI 1.1-1.5) and inactive
overweight (HR 1.4, 95% CI 1.2-1.6) had higher risk for any psychotropic
medication compared with group of highly active normal-weight. After adjusting
for prior medication, only the inactive overweight group had higher risk (HR 1.4,
95% CI 1.2-1.6). Other covariates made but a minor contribution to the examined
associations. For antidepressants the associations were somewhat stronger than
for sedatives.
CONCLUSIONS: Both normal-weight and physical activity help prevent psychotropic
medication but physical activity dominates the association over normal-weight.
DOI: 10.1186/s12889-015-2346-5
PMCID: PMC4592569
PMID: 26432784 [Indexed for MEDLINE]
DOI: 10.1007/s11926-018-0720-x
PMCID: PMC5842278
PMID: 29516200 [Indexed for MEDLINE]
Avant RA(1), Charchenko CM(1), Alom M(1), Westerman ME(1), Maldonado F(1), Miest
T(1), Trost L(1).
Author information:
(1)Department of Urology, Mayo Clinic, Rochester, MN, USA.
1399. Adolesc Health Med Ther. 2016 Oct 21;7:117-124. eCollection 2016.
Author information:
(1)Division of Respiratory Diseases, Boston Children's Hospital, Boston, MA, USA.
While development of new treatments for cystic fibrosis (CF) has led to a
significant improvement in survival age, routine daily treatment for CF is
complex, burdensome, and time intensive. Adolescence is a period of decline in
pulmonary function in CF, and is also a time when adherence to prescribed
treatment plans for CF tends to decrease. Challenges to adherence in adolescents
with CF include decreased parental involvement, time management and significant
treatment burden, and adolescent perceptions of the necessity and value of the
treatments prescribed. Studies of interventions to improve adherence are limited
and focus on education, without significant evidence of success. Smaller studies
on behavioral techniques do not focus on adolescents. Other challenges for
improving adherence in adolescents with CF include infection control practices
limiting in-person interactions. This review focuses on the existing evidence
base on adherence intervention in adolescents with CF. Future directions for
efforts to optimize treatment adherence in adolescents with CF include reducing
treatment burden, developing patient-driven technology to improve tracking,
communication, and online support, and rethinking the CF health services model to
include assessment of individualized adherence barriers.
DOI: 10.2147/AHMT.S95637
PMCID: PMC5085292
PMID: 27799838
Conflict of interest statement: Dr. Gregory Sawicki has served on advisory boards
for Genentech, Novartis, and Vertex Pharmaceuticals and receives research funding
from the Cystic Fibrosis Foundation. Dr. Lara Bishay has received unrelated
research funding from Vertex Pharmaceuticals. The authors report no other
conflicts of interest in this work.
Psaros C(1), Haberer JE, Boum Y 2nd, Tsai AC, Martin JN, Hunt PW, Bangsberg DR,
Safren SA.
Author information:
(1)Department of Psychiatry, Behavioral Medicine Service, Massachusetts General
Hospital, One Bowdoin Square, 7th Floor, Boston, MA, 02114, USA,
cpsaros@partners.org.
Depression is one of the most prevalent psychiatric comorbidities of HIV and one
of the greatest barriers to HIV self-care and adherence. Despite this, little
consensus exists on how to best measure depression among people living with
HIV/AIDS (PLWHA) in African settings. Measurement of depression among PLWHA may
be confounded by somatic symptoms. Some research recommends excluding these items
to enhance measurement validity; sensitivity may be lost with this approach. We
sought to characterize depression among a cohort (N = 453) of PLWHA initiating
antiretroviral therapy in Uganda via factor analysis of a widely used measure of
depression, the Hopkins Symptom Checklist (HSCLD). Common factor analysis was
performed, associations between HSCLD and the Mental Health subscale of the
Medical Outcomes Study HIV (MOS-HIV) estimated, and a Cronbach's alpha calculated
to examine validity. Factor analysis yielded two factors: (1) somatic-cognitive
symptoms and (2) behavioral disengagement. Persons with more versus less advanced
disease (CD4 cell count of ≤200 cells/mm(3)) showed no statistically significant
differences in depression scores (1.7 vs. 1.7, P ≥ 0.5). Both factors were
significantly associated with the MOS-HIV (P < .01). Factor one was highly
reliable (α = .81); factor two had only modest reliability (α = .65).
Somatic-cognitive symptoms of depression and disengagement from life's activities
appear to be distinct components of depression in this sample. Consideration of
somatic items may be valuable in identifying depression in this setting.
DOI: 10.1007/s10461-014-0796-x
PMCID: PMC4360967
PMID: 24854877 [Indexed for MEDLINE]
Frequency of Missed Insulin Boluses in Type 1 Diabetes and Its Impact on Diabetes
Control.
Author information:
(1)Department of Pediatrics, Vanderbilt University Medical Center , Nashville,
Tennessee.
DOI: 10.1089/dia.2016.0142
PMCID: PMC4932778
PMID: 27203694 [Indexed for MEDLINE]
Timmers L(1), Boons CC(2), Verbrugghe M(3), van den Bemt BJ(4)(5), Van Hecke
A(3), Hugtenburg JG(2)(6).
Author information:
(1)Department of Clinical Pharmacology and Pharmacy, VU University Medical
Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
l.timmers@vumc.nl.
(2)Department of Clinical Pharmacology and Pharmacy, VU University Medical
Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
(3)University Centre of Nursing and Midwifery, Department of Public Health, Ghent
University, Ghent, Belgium.
(4)Department of Pharmacy, Sint Maartenskliniek, Nijmegen, The Netherlands.
(5)Department of Pharmacy, Radboud University Medical Center, Nijmegen, The
Netherlands.
(6)The EMGO Institute for Health and Care Research, VU University Medical Center,
Amsterdam, The Netherlands.
DOI: 10.1186/s12885-017-3110-2
PMCID: PMC5303208
PMID: 28187759 [Indexed for MEDLINE]
Author information:
(1)Department of Endocrinology, Bharti Hospital, Karnal, India.
(2)Department of Endocrinology, Golden Hospital, Jalandhar, India.
Author information:
(1)Department of Psychology, School of Life and Health Sciences, Aston
University, Birmingham B4 7ET, UK. g.heath1@aston.ac.uk.
(2)Department of Psychology, School of Life and Health Sciences, Aston
University, Birmingham B4 7ET, UK. r.cooke@aston.ac.uk.
(3)Manchester Centre for Health Psychology, University of Manchester, Coupland 1
Building, Coupland Street, Manchester M13 9PL, UK.
elaine.cameron@manchester.ac.uk.
DOI: 10.3390/healthcare3041228
PMCID: PMC4934641
PMID: 27417822
Gagnon MD(1), Waltermaurer E(2), Martin A(2), Friedenson C(2), Gayle E(2), Hauser
DL(2).
Author information:
(1)From the Institute for Family Health, New York, NY (MDG, EG, DLH); the
Benjamin Center, State University of New York, New Paltz (EW); the Institute for
Advanced Medicine, Mount Sinai Health System, New York (AM); and the University
of Pennsylvania School of Veterinary Medicine, Philadelphia (CF).
mgagnon@institute.org.
(2)From the Institute for Family Health, New York, NY (MDG, EG, DLH); the
Benjamin Center, State University of New York, New Paltz (EW); the Institute for
Advanced Medicine, Mount Sinai Health System, New York (AM); and the University
of Pennsylvania School of Veterinary Medicine, Philadelphia (CF).
Comment in
J Am Board Fam Med. 2017 Nov-Dec;30(6):848.
DOI: 10.3122/jabfm.2017.03.160129
PMID: 28484065 [Indexed for MEDLINE]
Author information:
(1)Texas A&M AgriLife Extension Service and Texas A&M University, College of
Medicine, College Station, Texas (MDF).
(2)Department of Kinesiology and Health Science, Stephen F. Austin State
University, Nacogdoches, Texas (AA).
Giving patients insight, knowledge, and skills, although important, may not alone
be enough for behavior change maintenance. Rather, the health care provider (HCP)
has an important role in fostering behavior change and maintenance by asking,
"Why do people change?" and "What can I do to help?" This review highlights 4
evidence-based factors related to medication adherence, when lifestyle is the
medicine. (1) Autonomy is the belief that one is the origin of his or her own
actions, and must be supported by the HCP (eg, "My HCP listens to how I would
like to do things regarding my health"). (2) Competence and confidence ensure
that patients believe they can succeed. These are gained through mastery
experience, vicarious experience, and through positive and constructive feedback
on past performance (eg, "My HCP conveys confidence in my ability to make changes
regarding my health"). (3) Coping planning is being able to formulate a plan of
intention, with the awareness of barriers and emotional regulation that can
inhibit patient behavior (eg, "I feel able to share my feelings with my HCP").
(4) Personal values of the patients are used to understand how and why they cope
when there is a threat to these values (eg, "My HCP tries to understand how I see
my health before suggesting any changes").
DOI: 10.1177/1559827617697922
PMCID: PMC6124947
PMID: 30202361
Author information:
(1)Departamento Psicología de la Salud, Universidad Miguel Hernández, Elche,
Spain.
(#)Contributed equally
DOI: 10.2196/12505
PMCID: PMC6604503
PMID: 31215517
Factors associated with medication adherence among heart failure patients and
their caregivers.
Author information:
(1)Department of Medicine, Columbia University Medical Center/New
York-Presbyterian Hospital, New York, United States.
DOI: 10.5430/jnep.v5n3p22
PMCID: PMC4307014
PMID: 25635204
Mapping the Asthma Care Process: Implications for Research and Practice.
Author information:
(1)Amsterdam School of Communication Research ASCoR, University of Amsterdam,
Amsterdam, the Netherlands. Electronic address: a.dima@uva.nl.
(2)Amsterdam School of Communication Research ASCoR, University of Amsterdam,
Amsterdam, the Netherlands; Institute of Applied Health Sciences, University of
Aberdeen, Foresterhill, Aberdeen, Scotland.
(3)Lyon Pharmaco-Epidemiology Unit, Faculte d'Odontologie, Universite Claude
Bernard Lyon 1, Lyon, France; Respiratory Medicine, Croix-Rousse University
Hospital, Lyon, France.
BACKGROUND: Whether people with asthma gain and maintain control over their
condition depends not only on the availability of effective drugs, but also on
multiple patient and health care professional (HCP) behaviors. Research in asthma
rarely considers how these behaviors interact with each other and drug
effectiveness to determine health outcomes, which may limit real-life
applicability of findings.
OBJECTIVE: The objective of this study was to develop a logic process model
(Asthma Care Model; ACM) that explains how patient and HCP behaviors impact on
the asthma care process.
METHODS: Within a European research project on asthma (ASTRO-LAB), we reviewed
asthma care guidelines and empirical literature, and conducted qualitative
interviews with patients and HCPs. Findings were discussed with the project team
and respiratory care experts and integrated in a causal model.
RESULTS: The model outlines a causal sequence of treatment events, from diagnosis
and assessment to treatment prescription, drug exposure, and health outcomes. The
relationships between these components are moderated by patient behaviors
(medication adherence, symptom monitoring, managing triggers, and exacerbations)
and HCP behaviors (medical care and self-management support). Modifiable and
nonmodifiable behavioral determinants influence the behaviors of patients and
HCPs. The model is dynamic as it includes feedback loops of behavioral and
clinical outcomes, which influence future patient and HCP decision making. Key
evidence for each relationship is summarized to derive research priorities and
clinical recommendations.
CONCLUSIONS: The ACM model is of interest to both researchers and practitioners,
and intended as a first version (ACM-v1) of a common framework for generating and
translating research evidence in asthma care.
Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.jaip.2016.04.020
PMID: 27283052 [Indexed for MEDLINE]
Author information:
(1)Department of Neurosurgery, JCHO Kobe Central Hospital.
Carotid artery stenting (CAS) has become a common treatment for carotid artery
stenosis. However, complications, such as an ischemic event, can occur with CAS
during intra- and post-operative periods. Among these ischemic complications,
plaque protrusion into the stent and thrombus on the stent have occurred after
CAS. We retrospectively evaluated the temporal profile and treatment options for
these complications in 32 consecutive cases who underwent CAS at our hospital
between April 2009 and December 2011. The cases were evaluated pre-operatively
for risk factors, as well as the plaque morphology and characteristics using
computed tomographic angiography (CTA), ultrasound (US), and magnetic resonance
imaging (MRI). Post-operatively, lesions were examined by CTA and/or US within 1
week of CAS. As a result, among the 32 cases, 8 experienced plaque protrusions or
thrombus, which were treated with medication (anti-platelet and/or
anti-coagulation reinforcement). In 7 of these 8 cases, the plaque protrusion or
thrombus was stabilized with medication alone. However, the remaining case showed
growth and migration of the plaque protrusion or thrombus when treated with
medication alone, and therefore, required further endovascular treatment. We
identified that a history of symptomatic cerebral infarction and plaques with
ulceration were risk factors for plaque protrusion or thrombus formation after
CAS, and pre dilatation can decrease the risk of these complications. Medication
was effective in most cases of plaque protrusion or thrombus; however, further
endovascular treatment was required when medication alone was unsuccessful.
DOI: 10.2176/nmc.oa.2014-0105
PMCID: PMC4533408
PMID: 25746309 [Indexed for MEDLINE]
Ruppar TM(1), Cooper PS(2), Mehr DR(3), Delgado JM(2), Dunbar-Jacob JM(4).
Author information:
(1)Sinclair School of Nursing, University of Missouri, Columbia, MO
ruppart@missouri.edu.
(2)Sinclair School of Nursing, University of Missouri, Columbia, MO.
(3)Department of Family and Community Medicine, University of Missouri, Columbia,
MO.
(4)School of Nursing, University of Pittsburgh, PA.
Comment in
J Am Heart Assoc. 2016 Jun 17;5(6):.
© 2016 The Authors. Published on behalf of the American Heart Association, Inc.,
by Wiley Blackwell.
DOI: 10.1161/JAHA.115.002606
PMCID: PMC4937243
PMID: 27317347 [Indexed for MEDLINE]
Coverage by the public health services of medication and vaccines for the
population with diabetes mellitus.
Monteiro CN(1), Gianini RJ(1), Goldbaum M(1), Cesar CL(2), Barros MB(3).
Author information:
(1)Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de
São Paulo, São Paulo, SP, Brasil, camilamonteiro02@usp.br.
(2)Faculdade de Saúde Pública, USP.
(3)Faculdade de Ciências Médicas, Universidade de Campinas.
This study analyzed the coverage by the public health service of expenses with
medication and vaccines for the adult population of São Paulo with self-reported
diabetes mellitus in 2003 and the implications for access to medicines and
vaccination campaigns programs. Data were collected by the Multicenter Health
Survey of São Paulo. The Unified Health System (SUS) was widely used by the
population for vaccination against influenza and pneumonia and there was
significant private sector participation for coverage of expenses with
medication, with an estimated coverage of 38% by SUS. There were no significant
differences in the prevalence of use of public services for vaccination among the
categories of variables studied, suggesting a universal distribution of
vaccination by the public health service. Unlike vaccinations, in 2003 the
coverage of medication expenses by the public health service was recent in
Brazil, which may explain the low level of coverage. An analysis of coverage of
vaccination and medication expenses in diabetes mellitus population since 2003
may contribute to be the basis for policies to broaden access of the population
to health services.
DOI: 10.1590/1413-81232015202.02112014
PMID: 25715149 [Indexed for MEDLINE]
Svärd A(1), Lahti J(2), Rahkonen O(2), Lahelma E(2), Lallukka T(2)(3).
Author information:
(1)Department of Public Health, Faculty of Medicine, University of Helsinki,
Tukholmankatu 8B, P.O. Box 20, 00014, Helsinki, Finland. anna.svard@helsinki.fi.
(2)Department of Public Health, Faculty of Medicine, University of Helsinki,
Tukholmankatu 8B, P.O. Box 20, 00014, Helsinki, Finland.
(3)Finnish Institute of Occupational Health, Helsinki, Finland.
BACKGROUND: Both obesity and mental health are major public health issues. This
study aimed to examine whether overweight and obesity among midlife employees are
associated with subsequent psychotropic medication. A further aim was to examine
the potential effect of key covariates on the association.
METHODS: The Helsinki Health Study baseline survey was conducted in 2000-2002
among 40-60-year-old employees of the City of Helsinki, Finland (n = 8960). The
participants were classified as of normal weight (18.5-24.9 kg/m(2)), overweight
(25-29.9 kg/m(2)), obese (30-34.9 kg/m(2)) or severely obese (≥35 kg/m(2)) based
on self-reported body mass index. Data on psychotropic medication purchases from
baseline to 2009 were derived from registers of the Social Insurance Institution
of Finland. The final analysis included 4760 women and 1338 men. Antidepressants
and sedatives were examined separately. Covariates included socio-demographic
factors, workload, health behaviours, physical functioning, somatic ill-health
and psychotropic medication prior to baseline. Hazard ratios (HR) for the first
psychotropic medication purchase were calculated using Cox regression analysis.
RESULTS: Third of women and quarter of men made at least one psychotropic
medication purchase during the follow-up. Adjusting for age, obese (HR = 1.57;
95 % CI = 1.10-2.24) and severely obese (HR = 2.15; 95 % CI = 1.29-3.56) men were
at risk of having psychotropic medication compared to men of normal weight. These
associations disappeared after further adjustment. Severe obesity remained
associated with subsequent sedative medication among the men even after full
adjustment (HR = 2.12; 95 % CI = 1.17-3.84). No associations were found among the
women.
CONCLUSIONS: Obese and severely obese men, but not women, were at risk of
psychotropic medication. Further studies are needed to deepen understanding of
the relationship between obesity and mental ill-health, and the possible
protecting effects of age, employment, and living environment.
DOI: 10.1186/s12888-016-0889-3
PMCID: PMC4896028
PMID: 27267751 [Indexed for MEDLINE]
Author information:
(1)a Department of Psychiatry and Human Behavior , The Warren Alpert Medical
School of Brown University , Providence , RI , USA.
(2)b Department of Psychology , University of Connecticut , Storrs , CT , USA.
DOI: 10.1080/09540121.2016.1154134
PMCID: PMC4963817
PMID: 26964014 [Indexed for MEDLINE]
Author information:
(1)Department of Clinical Services, Federal Neuro-Psychiatric Hospital, Benin
City, Nigeria.
DOI: 10.1590/2237-6089-2017-0077
PMID: 29768528 [Indexed for MEDLINE]
1416. J Cardiovasc Nurs. 2017 Jul/Aug;32(4):E9-E23. doi:
10.1097/JCN.0000000000000392.
Palacios J(1), Lee GA, Duaso M, Clifton A, Norman IJ, Richards D, Barley EA.
Author information:
(1)Jorge Palacios, MD, MSc PhD Student, Florence Nightingale Faculty of Nursing &
Midwifery, King's College London, London, UK. Geraldine A. Lee, PhD Senior
Lecturer, Florence Nightingale Faculty of Nursing & Midwifery, King's College
London, London, UK. Maria Duaso, PhD Lecturer, Florence Nightingale Faculty of
Nursing & Midwifery, King's College London, London, UK. Abigail Clifton, BSc
Research Assistant, Florence Nightingale Faculty of Nursing & Midwifery, King's
College London, London, UK. Ian J. Norman, PhD Executive Dean, Florence
Nightingale Faculty of Nursing & Midwifery, King's College London, London, UK.
Derek Richards, PhD Director of Clinical Research and Innovation, Silvercloud
Health, and School of Psychology, Trinity College Dublin, Ireland. Elizabeth
Alexandra Barley, PhD, CPsychol Professor in Health and Wellbeing, College of
Nursing, Midwifery and Healthcare, University of West London, UK.
DOI: 10.1097/JCN.0000000000000392
PMCID: PMC5469565
PMID: 28107251 [Indexed for MEDLINE]
DOI: 10.18553/jmcp.2016.22.12.1394
PMID: 27882830 [Indexed for MEDLINE]
Author information:
(1)Department of Health Services Research, CAPHRI Care and Public Health Research
Institute, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, The
Netherlands. Electronic address: Edward@atkinsonclark.com.
(2)UCB Pharma, 60 Allée de la Recherche, Brussels, Belgium. Electronic address:
Mata.Charokopou@ucb.com.
(3)UCB Pharma, 60 Allée de la Recherche, Brussels, Belgium.
(4)Department of Health Services Research, CAPHRI Care and Public Health Research
Institute, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, The
Netherlands. Electronic address: m.hiligsmann@maastrichtuniversity.nl.
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.yebeh.2017.11.015
PMID: 29248866 [Indexed for MEDLINE]
DOI: 10.1089/can.2017.0012
PMCID: PMC5569620
PMID: 28861516
Stamp KD(1), Dunbar SB(2), Clark PC(3), Reilly CM(2), Gary RA(2), Higgins M(2),
Ryan RM(4).
Author information:
(1)Boston College, USA stampk@bc.edu.
(2)Nell Hodgson Woodruff School of Nursing, Emory University, USA.
(3)Byrdine F. Lewis School of Nursing, Georgia State University, USA.
(4)Institute for Positive Psychology and Education Australian Catholic
University, Australia.
DOI: 10.1177/1474515115572047
PMCID: PMC4532663
PMID: 25673525 [Indexed for MEDLINE]
Is the Newest Vital Sign a Useful Measure of Health Literacy in HIV Disease?
Kordovski VM(1), Woods SP(1)(2), Avci G(1), Verduzco M(2), Morgan EE(2).
Author information:
(1)1 Department of Psychology, University of Houston, Houston, TX, USA.
(2)2 Department of Psychiatry, University of California-San Diego, San Diego, CA,
USA.
BACKGROUND: Limited health literacy is common among persons infected with HIV and
has been linked to poor mental and physical health outcomes, but there are no
well-validated screening measures of health literacy in this vulnerable clinical
population. The present study evaluates the usefulness of the Newest Vital Sign
(NVS) as a brief measure of health literacy in HIV disease.
METHODS: Seventy-eight HIV+ adults were administered the NVS, Rapid Estimate of
Adult Literacy in Medicine (REALM), and Single Item Literacy Screener (SILS).
Main criterion variables included plasma HIV viral load, medication management
capacity, self-efficacy for medication management, and perceived relationships
with healthcare providers.
RESULTS: The NVS showed good internal consistency and moderate correlations with
the REALM and SILS. Rates of limited health literacy were highest on the NVS
(30.3%) as compared to SILS (6.6%) and REALM (9.2%). A series of regressions
controlling for education showed that the NVS was incrementally predictive of
viral load, medication management capacity and self-efficacy, and relationships
with healthcare providers, above and beyond the REALM and SILS.
CONCLUSION: The NVS shows evidence of reliability, convergent validity, and
incremental criterion-related validity and thus may serve as useful screening
tool for assessing health literacy in HIV disease.
DOI: 10.1177/2325957417729753
PMCID: PMC5698171
PMID: 28877636 [Indexed for MEDLINE]
Author information:
(1)Department of Clinical Pharmacy & Pharmacy Administration, Faculty of
Pharmacy, University of Ibadan, Ibadan, Oyo State, Nigeria.
PMCID: PMC5012141
PMID: 27635097 [Indexed for MEDLINE]
DOI: 10.1371/journal.pone.0156711
PMCID: PMC4889035
PMID: 27249421 [Indexed for MEDLINE]
Author information:
(1)1 Department of Medicine, School of Medicine, University of North Carolina at
Chapel Hill, NC, USA.
(2)2 Department of Family Medicine, School of Medicine, University of Colorado,
Aurora, CO, USA.
(3)3 School of Social Work, University of North Carolina at Chapel Hill, NC, USA.
(4)4 Cecil G. Sheps Center for Health Services Research, University of North
Carolina at Chapel Hill, Chapel Hill, NC, USA.
(5)5 Department of Family Medicine, School of Medicine, University of North
Carolina at Chapel Hill, Chapel Hill, NC, USA.
DOI: 10.1177/1533317517711247
PMCID: PMC5529254
PMID: 28558474 [Indexed for MEDLINE]
Rohde D(1), Merriman NA(1), Doyle F(1), Bennett K(1), Williams D(2), Hickey A(1).
Author information:
(1)Division of Population Health Sciences, Royal College of Surgeons in Ireland,
Dublin, Ireland.
(2)Department of Geriatric and Stroke Medicine, Beaumont Hospital and Royal
College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
Author information:
(1)Research Area, Family and Community Medicine Division, Hospital Italiano de
Buenos Aires, Buenos Aires, Argentina.
(2)Department of Public Health, Instituto Universitario Hospital Italiano and
Research Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
(3)Department of Research, Instituto Universitario Hospital Italiano, Buenos
Aires, Argentina.
(4)Department of Toxicology and Pharmacology, Universidad de, Buenos Aires,
Argentina.
OBJECTIVES: The objective of this study is to describe the frequency and type of
medication discrepancies (MD) through medication reconciliation and to describe
the frequency of potentially inadequate prescription (PIP) medications using
screening tool of older persons' prescriptions criteria.
DESIGN: Cross-sectional comparison of electronic medical record (EMR) medication
lists and patient's self-report of their comprehensive medication histories
obtained through telephone interviews.
INCLUSION CRITERIA: Elderly individuals (>65 years old) with more than ten
medications recorded in their EMR, who had not been hospitalized in the past year
and were not under domiciliary care, affiliated to a private community hospital.
OUTCOME MEASURES: The primary outcomes were the proportion of patients with MD
and PIP. Secondary outcomes were the proportion of types of discrepancies and
PIP. We analyzed possible associations between these variables and other
demographic and clinical variables.
RESULTS: Out of 214 randomly selected individuals, 150 accepted to participate
(70%). The mean number of medications referred to be consumed by patients was 9.1
(95% confidence interval [CI] =8.6-9.6), and the mean number of prescribed
medications in their EMR was 13.9 (95% CI = 13.3-14.5). Ninety-nine percent had
at least one discrepancy (total 1252 discrepancies); 46% consumed at least one
prescription not documented in their EMR and 93% did not consume at least one of
the prescriptions documented in their EMR. In 77% of the patients, a PIP was
detected (total 186), 87% of them were at least within one of the following
categories: Prolonged used of benzodiazepines or proton pump inhibitors and the
use of aspirin for the primary prevention of cardiovascular disease.
CONCLUSIONS: There was a high prevalence of MD and PIP within the community of
elderly adults affiliated to a Private University Hospital. Future interventions
should be aimed at reducing the number of PIP to prevent adverse drug events and
improve EMR accuracy by lowering medications discrepancies.
DOI: 10.4103/2249-4863.214962
PMCID: PMC5629905
PMID: 29026754
Author information:
(1)Clinical Pharmacy Department, Georges Pompidou European Hospital, AP-HP, 20
rue Leblanc, Paris, France, 75015.
DOI: 10.1002/14651858.CD012042.pub2
PMCID: PMC6491069
PMID: 29320600 [Indexed for MEDLINE]
Author information:
(1)School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast,
United Kingdom.
(2)School of Pharmacy, Royal College of Surgeons in Ireland, 111 St. Stephens
Green, Dublin 2, Ireland.
(3)School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast,
United Kingdom. cristinryan@rcsi.ie.
(4)School of Pharmacy, Royal College of Surgeons in Ireland, 111 St. Stephens
Green, Dublin 2, Ireland. cristinryan@rcsi.ie.
DOI: 10.1007/s40266-016-0426-6
PMCID: PMC5290062
PMID: 28025725 [Indexed for MEDLINE]
Atkinson TM(1), Rodríguez VM(1), Gordon M(1), Avildsen IK(1), Emanu JC(1), Jewell
ST(2), Anselmi KA(1), Ginex PK(1).
Author information:
(1)Memorial Sloan Kettering Cancer Center.
(2)Rutgers University.
PROBLEM IDENTIFICATION: Oral anticancer medication (OAM) use has been steadily
increasing, leading to several patient benefits. A notable challenge for nurses
is accurate monitoring of patient OAM regimens because nonadherence is associated
with poor health outcomes and decreased survival. Currently, no gold standard
measure of OAM adherence exists. The authors conducted a systematic review of the
association between objective and patient-reported measures of OAM adherence..
LITERATURE SEARCH: A systematic electronic literature search was conducted using
PubMed, EMBASE, Scopus, PsycINFO®, Cochrane Library, Web of Science, and CINAHL®
databases through November 2014. .
DATA EVALUATION: Articles were independently reviewed to determine whether they
included an original characterization of the level of association between
objective and patient-reported measures of OAM adherence..
SYNTHESIS: From a total of 11,135 articles retrieved, eight studies met inclusion
criteria. Objective adherence was primarily assessed using pill counts or
Medication Event Monitoring System (MEMSCap™). Patient-reported adherence was
most commonly assessed using study-specific questionnaires. Significant positive
correlations were observed between objective and patient-reported adherence
across most studies, with three studies reporting higher rates of adherence via
patient reporting..
CONCLUSIONS: Despite variation in the OAMs and measures used, patient-reported
adherence rates were equal to or higher than objective adherence measures across
studies. Social desirability bias may be a concern; however, given the
significant concordance observed, using patient-reported methods in future
studies of OAM adherence may be justified. .
IMPLICATIONS FOR NURSING: This review provides evidence to support nursing use of
patient-reported measures to accurately monitor OAM adherence and potentially
improve the quality of patient-provider communication.
DOI: 10.1188/16.ONF.576-582
PMCID: PMC5008846
PMID: 27541550 [Indexed for MEDLINE]
1430. BMJ Open Diabetes Res Care. 2017 May 8;5(1):e000349. doi:
10.1136/bmjdrc-2016-000349. eCollection 2017.
Author information:
(1)Department of Family Medicine, University of Texas Medical Branch, Galveston,
Texas, USA.
(2)Department of Anthropology, University of South Florida, Tampa, Florida, USA.
(3)Department of Preventive Medicine and Community Health, University of Texas
Medical Branch, Galveston, Texas, USA.
OBJECTIVE: This project explored lifestyles of patients in good and poor control
to identify naturally occurring practices and strategies that result in
successful diabetes management.
RESEARCH DESIGN AND METHODS: Semistructured interviews with adult patients with
type 2 diabetes explored diet, food preparation, physical activity, medication
use and glucose monitoring. Patients (n=56) were classified into good (A1C
<7.0%), fair (7.0%<A1C<8.0%) or poor (A1C >8.0%) control groups and matched
across groups on diabetes duration (±5 years) and medication modality (none,
oral, insulin±oral) to control for non-lifestyle factors. A qualitative
comparative analysis identified practices that distinguished glycemic groups.
RESULTS: Good control patients were more likely to test their glucose two or more
times a day and reduce their sodium intake, as well as increase fruits and
vegetables and limit portion sizes, some attaining good control without exercise.
Fair control patients discussed several dietary strategies including limiting
sweets, drinking non-caloric beverages, reducing carbs, 'cheating' (eating only a
few sweets/limiting carbs in one meal to have more in another meal) and tested
their glucose once a day. Poor control patients were more likely to skip
antidiabetic medications and not test their glucose.
CONCLUSIONS: Although clinical trials indicate most self-management practices
have limited effectiveness over time, increased glucose monitoring is a valuable
component in daily management. Research is needed on effectiveness of dietary
strategies that emphasize sodium monitoring and allow some degree of cheating.
Reoffering diabetes education classes and providing pill boxes as memory aids may
help improve poor control.
DOI: 10.1136/bmjdrc-2016-000349
PMCID: PMC5530238
PMID: 28761649
DOI: 10.1016/j.pedhc.2014.02.008
PMCID: PMC4273905
PMID: 24786582 [Indexed for MEDLINE]
"Patients Are Not Following the [Adherence] Club Rules Anymore": A Realist Case
Study of the Antiretroviral Treatment Adherence Club, South Africa.
Mukumbang FC(1)(2), Marchal B(1)(2), Van Belle S(2), van Wyk B(1).
Author information:
(1)1 University of the Western Cape, Bellville, South Africa.
(2)2 The Institute of Tropical Medicine, Antwerp, Belgium.
DOI: 10.1177/1049732318784883
PMCID: PMC6154254
PMID: 30033857 [Indexed for MEDLINE]
George M(1), Abboud S(2), Pantalon MV(3), Sommers ML(2), Mao J(4), Rand C(5).
Author information:
(1)Columbia University School of Nursing, USA. Electronic address:
mg3656@cumc.columbia.edu.
(2)University of Pennsylvania School of Nursing, USA.
(3)Department of Psychiatry, School of Medicine, Yale University, USA; Department
of Emergency Medicine, School of Medicine, Yale University, USA.
(4)University of Pennsylvania, Perelman School of Medicine, USA.
(5)Johns Hopkins University School of Medicine, USA.
DOI: 10.1016/j.hrtlng.2015.11.002
PMCID: PMC4691278
PMID: 26702503 [Indexed for MEDLINE]
DOI: 10.1186/s12888-014-0273-0
PMCID: PMC4189597
PMID: 25248639 [Indexed for MEDLINE]
Kebaabetswe PM(1), Stirratt MJ, McLellan-Lemal E, Henderson FL, Gray SC, Rose CE,
Williams T, Paxton LA.
Author information:
(1)HIV Prevention Research Unit, CDC Botswana, Gaborone, Botswana,
poloko.kebaabetswe@mopipi.ub.bw.
This study examined study product adherence and its determinants in the Botswana
oral pre-exposure prophylaxis efficacy trial. Among the 1,219 participants, the
mean adherence by pill count and 3-day self-report was 94 % for each. In
multivariable models, pill count adherence was significantly associated with
adverse events (nausea, dizziness, vomiting) (RR 0.98 95 % CI 0.98-1.00; p =
0.03) and side effect concerns (RR 0.98 95 % CI 0.96-0.99; p = 0.01).
Self-reported adherence was significantly associated with having an HIV-positive
partner (RR 1.02 95 % CI 1.00-1.04; p = 0.02) and Francistown residence (RR 0.98
95 % CI 0.96, 0.99; p = 0.0001). Detectable drug concentrations showed modest
associations with self-report and pill count adherence, and drug levels were
higher among those self-reporting 100 % adherence than those reporting <100 %.
Most common adherence barriers involved refill delays and other logistic
challenges; cellphone alarm reminder use was the most common facilitator.
DOI: 10.1007/s10461-014-0891-z
PMCID: PMC4586059
PMID: 25186785 [Indexed for MEDLINE]
Ruvalcaba E(1), Chung SE(1), Rand C(1), Riekert KA(1), Eakin M(1).
Author information:
(1)a Division of Pulmonary and Critical Care Medicine , Johns Hopkins School of
Medicine , Baltimore , MD , USA.
DOI: 10.1080/02770903.2018.1443467
PMCID: PMC6139065
PMID: 29543493
Author information:
(1)School of Nursing College of Health Science, Mekelle Univesity, Mekelle,
Tigray, Ethiopia. Neverimpossible12@yahoo.com.
(2)School of Nursing College of Health Science, Mekelle Univesity, Mekelle,
Tigray, Ethiopia.
DOI: 10.1186/s13104-019-4502-y
PMCID: PMC6685278
PMID: 31387617
Chamany S(1), Walker EA(2), Schechter CB(3), Gonzalez JS(4), Davis NJ(5), Ortega
FM(1), Carrasco J(6), Basch CE(7), Silver LD(8).
Author information:
(1)New York City Department of Health and Mental Hygiene, New York, New York.
(2)Albert Einstein College of Medicine, Bronx, New York. Electronic address:
Elizabeth.Walker@einstein.yu.edu.
(3)Albert Einstein College of Medicine, Bronx, New York.
(4)Albert Einstein College of Medicine, Bronx, New York; Ferkauf Graduate School
of Psychology, Yeshiva University, Bronx, New York.
(5)Albert Einstein College of Medicine, Bronx, New York; North Bronx Healthcare
Network, Bronx, New York.
(6)Montefiore Medical Center, Bronx, New York.
(7)Teachers College, Columbia University, New York, New York;
(8)Public Health Institute, Oakland, California.
DOI: 10.1016/j.amepre.2015.04.016
PMCID: PMC4656092
PMID: 26232903 [Indexed for MEDLINE]
Knäuper B(1), Carrière K(1), Chamandy M(2), Xu Z(1), Schwarz N(3), Rosen NO(4).
Author information:
(1)Department of Psychology, McGill University, Montreal, Canada.
(2)School of Psychology, University of Ottawa, Ottawa, Canada.
(3)Department of Psychology, University of Southern California, Los Angeles, CA
USA.
(4)Department of Psychology and Neuroscience, Dalhousie University, Halifax,
Canada.
DOI: 10.1007/s10433-016-0369-0
PMCID: PMC5550601
PMID: 28804377
Pisaniello HL(1), Lester S(2)(3), Gonzalez-Chica D(4), Stocks N(4), Longo M(5),
Sharplin GR(6), Dal Grande E(3), Gill TK(3), Whittle SL(2)(3), Hill CL(2)(3).
Author information:
(1)Department of Rheumatology, The Queen Elizabeth Hospital, Woodville South,
Australia. huaileng@gmail.com.
(2)Department of Rheumatology, The Queen Elizabeth Hospital, Woodville South,
Australia.
(3)Discipline of Medicine, Faculty of Health and Medical Sciences, The University
of Adelaide, Adelaide, Australia.
(4)Discipline of General Practice, Adelaide Medical School, The University of
Adelaide, Adelaide, Australia.
(5)Drug and Alcohol Services South Australia, Stepney, Australia.
(6)Behavioural Research and Evaluation Unit, Cancer Council South Australia,
Eastwood, Australia.
DOI: 10.1186/s13075-018-1633-9
PMCID: PMC6042461
PMID: 29996922 [Indexed for MEDLINE]
Life Lessons from Women with HIV: Mutuality, Self-Awareness, and Self-Efficacy.
Brody LR(1), Jack DC(2), Bruck-Segal DL(1), Ruffing EG(1), Firpo-Perretti YM(1),
Dale SK(3), Weber KM(4), Cohen MH(5).
Author information:
(1)1 Department of Psychological and Brain Sciences, Boston University , Boston,
Massachusetts.
(2)2 Fairhaven College of Interdisciplinary Studies, Western Washington
University , Bellingham, Washington.
(3)3 Behavioral Medicine Service, Massachusetts General Hospital , Boston,
Massachusetts.
(4)4 Cook County Health and Hospitals System, Hektoen Institute of Medicine ,
Chicago, Illinois.
(5)5 Department of Medicine, Stroger Hospital , Cook County Health & Hospitals
System, and Rush University, Chicago, Illinois.
Women with HIV in the United States cope with multiple traumas that influence
adherence to antiretroviral therapy (ART) and well-being. Narrative themes from
three life turning points and a projective story task were compared for two
groups of women with HIV (HIV well-managed vs. HIV not well-managed, matched on
demographics and narrative word count) to understand predictors of successful
outcomes. The well-managed group (n = 10) was virally suppressed and reported
≥95% ART adherence; the not well-managed group (n = 10) had detectable viral load
and reported <95% ART adherence. Women were predominantly African American with
low socioeconomic status and averaged 46.51 years. A three-stage coding process
(with coders blind to group status in stages 1 and 2) involved (1) line by line
thematic analyses that generated 155 subthemes reflecting six content areas
(interpersonal relationships; culture and community; sense of self; relationship
to past, present, and future experiences; self-care; and motivators for change);
(2) absence/presence of the 155 subthemes was compared for the two groups; the
frequency of 37 subthemes was found to significantly differ; and (3) the 37
differentiating subthemes were conceptually integrated, revealing that the
well-managed group's narratives more frequently reflected (a) mutuality
(growth-fostering relationships involving reciprocal care and empathy); (b)
self-awareness (recognition of personal strengths and weaknesses and multiple
factors contributing to life choices and trajectories); and (c) self-efficacy
(active coping, self-advocacy, and utilizing resources). Implications for
treatment and interconnections among themes are discussed, emphasizing the
factors that enable women to care for themselves and others.
DOI: 10.1089/apc.2016.0031
PMCID: PMC4913488
PMID: 27214648 [Indexed for MEDLINE]
Results from the Trial Using Motivational Interviewing, Positive Affect, and
Self-Affirmation in African Americans with Hypertension (TRIUMPH).
Boutin-Foster C(1), Offidani E(1), Kanna B(2), Ogedegbe G(2), Ravenell J(3),
Scott E(4), Rodriguez A(1), Ramos R(1), Michelen W(2), Gerber LM(5), Charlson
M(1).
Author information:
(1)Weill Cornell Medical College, Department of Medicine.
(2)Lincoln Medical Center, Department of Administration.
(3)New York University School of Medicine, Department of Population Health.
(4)New York University Langone Medical Center.
(5)Weill Cornell Medical College, Department of Healthcare Policy and Research.
OBJECTIVE: Our objective was to determine the effectiveness of combining positive
affect and self-affirmation strategies with motivational interviewing in
achieving blood pressure control among hypertensive African Americans (AA)
compared with AA hypertensives in an education-only control group.
DESIGN: Randomized trial.
SETTING: Ambulatory practices in the South Bronx and Harlem, New York City.
PARTICIPANTS: African American adults with uncontrolled hypertension.
INTERVENTIONS: Participants were randomized to a positive affect and
self-affirmation intervention or an education control group. The positive affect
and self-affirmation intervention involved having participants think about things
that made them happy and that reminded them of their core values on a daily
basis. These strategies were reinforced every two months through motivational
interviewing. The control arm received a workbook of strategies on blood pressure
control. All participants were called every two months for one year.
MAIN OUTCOMES: Blood pressure control rate.
RESULTS: A total of 238 participants were randomized. The average age was 56 ± 11
years, approximately 70% were female, 80% were not married, and up to 70% had
completed high school. There was no difference in control rates between the
intervention and the control group. However, at one year, female participants
were more likely to be controlled. Participants with high depressive symptoms or
high perceived stress at baseline were less likely to be controlled.
CONCLUSIONS: While this study did not demonstrate an intervention effect, it does
provide important insight into the psychosocial factors that may underlie blood
pressure control in African Americans. Implications for future behavioral
intervention trials are discussed.
DOI: 10.18865/ed.26.1.51
PMCID: PMC4738855
PMID: 26843796 [Indexed for MEDLINE]
1443. Int J Environ Res Public Health. 2018 Oct 29;15(11). pii: E2403. doi:
10.3390/ijerph15112403.
Alquran A(1), Lambert KA(2), Farouque A(3), Holland A(4), Davies J(5), Lampugnani
ER(6), Erbas B(7).
Author information:
(1)School of Public Health, College of Science Health and Engineering, La Trobe
University, Bundoora 3083, Victoria, Australia. alaalmahmoud7@gmail.com.
(2)School of Public Health, College of Science Health and Engineering, La Trobe
University, Bundoora 3083, Victoria, Australia. k.lambert@latrobe.edu.au.
(3)School of Public Health, College of Science Health and Engineering, La Trobe
University, Bundoora 3083, Victoria, Australia. amber.farouque@gmail.com.
(4)Alfred Health Clinical School, Department of Rehabilitation, Nutrition and
Sport, School of Allied Health, College of Science Health and Engineering, La
Trobe University, Bundoora 3083, Victoria, Australia. A.Holland@latrobe.edu.au.
(5)Faculty of Health, School-Biomedical Sciences, Queensland University of
Technology, Brisbane 4000, Queensland, Australia. j36.davies@qut.edu.au.
(6)School of Biosciences, the University of Melbourne, Melbourne 3010, Australia.
edwin.lampugnani@unimelb.edu.au.
(7)School of Public Health, College of Science Health and Engineering, La Trobe
University, Bundoora 3083, Victoria, Australia. b.erbas@latrobe.edu.au.
DOI: 10.3390/ijerph15112403
PMCID: PMC6266660
PMID: 30380692 [Indexed for MEDLINE]
Author information:
(1)Department of Pharmacy, Guys and St Thomas NHS Foundation Trust, London, UK.
DOI: 10.1136/ejhpharm-2016-001008
PMCID: PMC6451457
PMID: 31156900
Assessing the Plain Language Planner for Communication About Common Palliative
Care Medications.
Author information:
(1)Communication Studies, California State University, Los Angeles, California.
(2)City of Hope National Medical Center, Division of Nursing Research and
Education, Duarte, California.
(3)Department of Communication, University of Memphis, Memphis, Tennessee.
PMCID: PMC6167079
PMID: 30310720
Author information:
(1)Technical University of Madrid, Av. Complutense 30, 28040, Madrid, Spain,
diego.martin.de.andres@upm.es.
DOI: 10.1007/s10916-015-0298-z
PMCID: PMC4540754
PMID: 26286317 [Indexed for MEDLINE]
Ross M(1), Nguyen V(1), Bridges JFP(2), Ng X(1), Reeves G(3), Frosch E(4),
dosReis S(1).
Author information:
(1)Department of Pharmaceutical Health Services Research, University of Maryland
School of Pharmacy, Baltimore, MD.
(2)Department of Health Policy and Management, Johns Hopkins Bloomberg School of
Public Health, Baltimore, MD.
(3)Department of Psychiatry, Division of Child and Adolescent Psychiatry,
University of Maryland School of Medicine, Baltimore, MD.
(4)Department of Psychiatry, Division of Child and Adolescent Psychiatry, Johns
Hopkins University School of Medicine, Baltimore, MD.
DOI: 10.1097/DBP.0000000000000530
PMCID: PMC5863279
PMID: 29461996 [Indexed for MEDLINE]
1448. Patient Prefer Adherence. 2018 Apr 23;12:615-624. doi: 10.2147/PPA.S159113.
eCollection 2018.
Ng YK(1), Shah NM(1), Loong LS(2), Pee LT(3), Hidzir SAM(4), Chong WW(1).
Author information:
(1)Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
(2)Department of Pharmacy, Universiti Kebangsaan Malaysia Medical Centre, Kuala
Lumpur, Malaysia.
(3)Department of Pharmacy, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
(4)Department of Pharmacy, Hospital Sungai Buloh, Selangor, Malaysia.
DOI: 10.2147/PPA.S159113
PMCID: PMC5923248
PMID: 29731609
Bolus Insulin Dose Error Distributions Based on Results From Two Clinical Trials
Comparing Blood Glucose Monitoring Systems.
Author information:
(1)1 Ascensia Diabetes Care, Parsippany, NJ.
DOI: 10.1177/1932296817713025
PMCID: PMC5950998
PMID: 28604064 [Indexed for MEDLINE]
Author information:
(1)Departments of *Ophthalmology & Visual Sciences §Internal Medicine, University
of Michigan Medical School †School of Public Health ‡School of Social Work,
University of Michigan, Ann Arbor, MI.
DOI: 10.1097/IJG.0000000000000431
PMCID: PMC5067955
PMID: 27096721 [Indexed for MEDLINE]
Leggett A(1), Kavanagh J(2), Zivin K(3), Chiang C(4), Kim HM(5), Kales HC(4).
Author information:
(1)Department of Psychiatry, University of Michigan Medical School, Ann Arbor,
MI, USA leggetta@med.umich.edu.
(2)Department of Psychiatry, University of Michigan Medical School, Ann Arbor,
MI, USA.
(3)Department of Psychiatry, University of Michigan Medical School, Ann Arbor,
MI, USA Department of Veterans Affairs, Center for Clinical Management Research,
Ann Arbor, MI, USA Department of Health Management and Policy, University of
Michigan School of Public Health, Ann Arbor, MI, USA Institute for Social
Research, University of Michigan, Ann Arbor, MI, USA.
(4)Department of Psychiatry, University of Michigan Medical School, Ann Arbor,
MI, USA Department of Veterans Affairs, Center for Clinical Management Research,
Ann Arbor, MI, USA.
(5)Center for Statistical Consultation & Research, University of Michigan, Ann
Arbor, MI, USA Department of Biostatistics, University of Michigan, Ann Arbor,
MI, USA.
DOI: 10.1177/0891988715598227
PMCID: PMC4927262
PMID: 26269493 [Indexed for MEDLINE]
Di Bartolomeo S(1), Marino M(1), Guastaroba P(1), Valent F(2), De Palma R(1).
Author information:
(1)Regional Agency for Health and Social Care of Emilia-Romagna/Azienda
Ospedaliero-Universitaria di Udine, Bologna/Udine, Italy (S.D.B., M.M., P.G.,
R.D.P.).
(2)Servizio di Epidemiologia, Direzione Centrale Salute, Integrazione
Sociosanitaria e Politiche Sociali, Regione Autonoma Friuli Venezia Giulia,
Udine, Italy (F.V.).
© 2015 The Authors. Published on behalf of the American Heart Association, Inc.,
by Wiley Blackwell.
DOI: 10.1161/JAHA.114.001575
PMCID: PMC4330079
PMID: 25567050 [Indexed for MEDLINE]
1453. Addiction. 2017 Apr;112(4):673-682. doi: 10.1111/add.13685. Epub 2016 Dec 12.
How do text-messaging smoking cessation interventions confer benefit? A multiple
mediation analysis of Text2Quit.
Author information:
(1)Department of Psychiatry, Massachusetts General Hospital, Harvard Medical
School, Boston, MA, USA.
(2)Department of Prevention and Community Health, Milken Institute School of
Public Health, George Washington University, Washington, DC, USA.
Comment in
Addiction. 2017 Apr;112(4):683-684.
AIMS: To determine the degree to which the observed benefit of Text2Quit was
accounted for by psychosocial mechanisms derived from its quit smoking messaging
versus from the use of extra-programmatic smoking cessation treatments and
services.
DESIGN: Prospective, multiple mediation model of a randomized controlled trial
(RCT).
SETTING: United States nation-wide.
PARTICIPANTS: A total of 409 adult daily smokers participated. Participants were,
on average, 35 years of age, predominantly female (68%), white (79%), lacked a
college degree (70%), had medium nicotine dependence (average Fagerström Nicotine
Dependence Score score of 5.2) and more than half (62%) had made a previous quit
attempt.
INTERVENTION: Adult daily smokers browsing the web for smoking cessation support
(n = 409; recruited 19 May2011-10 July 2012) were randomized to receive smoking
cessation support via Text2Quit versus a smoking cessation material.
MEASUREMENTS: Mediators (i.e. changes in psychosocial constructs of health
behavior change, use of extra-programmatic treatment) were assessed at 1 month
using single-item measures and outcome (i.e. self-reported 7-day point prevalence
abstinence) at 6-month follow-up.
FINDINGS: Mediators accounted for 35% of the effect of Text2Quit on smoking
cessation. Only psychosocial mechanisms had complete mediational paths, with
increases in self-efficacy [b = 0.10 (0.06-0.15)], quitting know-how [b = 0.07
(0.03-0.11)] and the sense that someone cared [b = 0.06 (0.01-0.11)], partially
explaining the conferred benefit of Text2Quit. Use of outside resources,
including treatments promoted explicitly by Text2Quit, i.e. medication [b = 0.001
(-0.01 to 0.01), quitline [b = -0.002 (-0.01 to 0.04)], treatments and resources
not promoted by Text2Quit, i.e. online forums [b = 0.01 (-0.01 to 0.04)] and
self-help materials [b = -0.01 (-0.04 to 0.02)], did not have complete
mediational paths. An interaction effect existed for medication use that
suggested that for participants not using medication, Text2Quit conferred
substantial benefit, but not for participants using medication.
CONCLUSIONS: Text-messaging programs for smoking cessation appear primarily to
confer benefit by promoting improvements in the psychosocial processes related to
quitting rather than through the use of extra-programmatic smoking cessation
treatments and services.
DOI: 10.1111/add.13685
PMCID: PMC6067921
PMID: 27943511 [Indexed for MEDLINE]
Triple Smoking Cessation Therapy with Varenicline, Nicotine Patch and Nicotine
Lozenge: A Pilot Study to Assess Tolerability, Satisfaction, and End-of-Treatment
Quit Rates.
Author information:
(1)Division of General Internal Medicine, Department of Medicine, University of
Wisconsin School of Medicine and Public Health, 2828 Marshall Ct, Suite 100,
Madison, WI USA 53705.
(2)Center for Tobacco Research and Intervention, University of Wisconsin School
of Medicine and Public Health, 1930 Monroe St, Suite 200, Madison, WI USA 53711.
(3)Primary Care Research Fellowship, Department of Family Medicine and Community
Health, University of Wisconsin School of Medicine and Public Health, 1100
Delaplaine Ct, Madison, WI USA 53715.
Introduction: The majority of attempts to stop smoking end in failure. One way to
improve success may be to explore different combinations of existing cessation
medications.
Aims: This observational study examined "triple therapy" (varenicline + nicotine
patch + nicotine lozenge) in 36 smokers trying to quit.
Methods: A 12-week, observational study exploring tolerability, via adverse
events (AEs) elicited at each of 9 phone assessments. Secondary outcomes included
satisfaction rates, medication changes, and self-reported quit rates at week 12.
Results: 35 of 36 participants reported at least one AE. Insomnia (75%), abnormal
dreams (72%) and nausea (64%) were most common. Most were mild to moderate. No
deaths, hospitalizations, cardiovascular events, or suicidality were reported.
Six participants (17%) decreased the dose of at least one medication, 5 (14%)
decreased the dose then discontinued at least one medication, and 13 (36%)
discontinued at least one medication without trying a lesser dose. Participants
were highly satisfied with their medications, and 58% reported quitting at 12
weeks, with 38% reporting prolonged abstinence.
Conclusion: Despite high rates of AEs and medication changes, high rates of
satisfaction and self-reported quitting, with no serious AEs, were observed with
triple therapy. Additional data on tolerability and efficacy are needed.
Trial Registration: clinicaltrials.gov number NCT02681510.
DOI: 10.1017/jsc.2017.18
PMCID: PMC6277035
PMID: 30524509
Author information:
(1)Program in Public Health and Department of Family, Population and Preventative
Medicine, Stony Brook University, Health Sciences Center, Stony Brook, NY.
(2)Perinatal HIV Research Unit, Faculty of Health Sciences, University of the
Witwatersrand, Johannesburg, South Africa.
DOI: 10.1097/QAI.0000000000001569
PMCID: PMC5720896
PMID: 29040165 [Indexed for MEDLINE]
Author information:
(1)Msc in health education, Elderly Health Research Center, Shahid Sadoughi
University of Medical Sciences,Yazd , Iran. hrezaeipandari@yahoo.com.
DOI: 10.5539/gjhs.v7n5p33
PMCID: PMC4803867
PMID: 26156902 [Indexed for MEDLINE]
Befus DR(1), Hull S(2), Strand de Oliveira J(2), Schmidler GS(3), Weinberger
M(4), Coeytaux RR(5).
Author information:
(1)Arthur Labatt Family School of Nursing, Western University Faculty of Health
Sciences, London, Ontario, Canada.
(2)Department of Community and Family Medicine, Duke University School of
Medicine, Durham, North Carolina.
(3)Department of Population Health Sciences, Duke University School of Medicine,
Durham, North Carolina.
(4)Gillings School of Global Public Health, University of North Carolina at
Chapel Hill, Chapel Hill, North Carolina.
(5)Department of Family and Community Medicine, Wake Forest University School of
Medicine, Winston-Salem, North Carolina.
DOI: 10.1177/2164956119858034
PMCID: PMC6566474
PMID: 31223518
Author information:
(1)Psychology and Sport Sciences Department, School of Life and Medical Sciences,
University of Hertfordshire, Hatfield, United Kingdom.
(2)The Royal London Hospital Haemophilia Centre, Barts Health NHS Trust, London,
United Kingdom.
(3)Barts and The London School of Medicine and Dentistry, QMUL, London, United
Kingdom.
DOI: 10.1371/journal.pone.0169880
PMCID: PMC5245860
PMID: 28103266 [Indexed for MEDLINE]
Gamarel KE(1), Neilands TB, Dilworth SE, Taylor JM, Johnson MO.
Author information:
(1)a Department of Psychiatry and Human Behavior , Alpert Medical School of Brown
University , Providence , RI , USA.
DOI: 10.1080/09540121.2014.991269
PMCID: PMC4336592
PMID: 25506724 [Indexed for MEDLINE]
1460. J Manag Care Spec Pharm. 2017 May 30:1-11. doi: 10.18553/jmcp.2017.17100.
[Epub
ahead of print]
Optimization of Medication Use at Accountable Care Organizations.
Wilks C(1), Krisle E(1), Westrich K(2), Lunner K(1), Muhlestein D(1), Dubois
R(2).
Author information:
(1)1 Leavitt Partners, Salt Lake City, Utah.
(2)2 National Pharmaceutical Council, Washington, DC.
DOI: 10.18553/jmcp.2017.17100
PMID: 29406837
Thorneloe RJ(1), Griffiths CEM(2), Emsley R(3), Ashcroft DM(4), Cordingley L(5);
British Association of Dermatologists Biologic Interventions Register; Psoriasis
Stratification to Optimise Relevant Therapy Study Groups.
Author information:
(1)Division of Pharmacy and Optometry, School of Health Sciences, Faculty of
Biology, Medicine and Health, University of Manchester, Manchester, UK; Centre
for Dermatology Research, Manchester Academic Health Science Centre and NIHR
Manchester Biomedical Research Centre, University of Manchester, Manchester, UK.
Electronic address: Rachael.Thorneloe@manchester.ac.uk.
(2)Centre for Dermatology Research, Manchester Academic Health Science Centre and
NIHR Manchester Biomedical Research Centre, University of Manchester, Manchester,
UK; Salford Royal Hospital NHS Foundation Trust, Salford, UK; Division of
Musculoskeletal and Dermatological Sciences, Manchester Academic Health Science
Centre and NIHR Manchester Biomedical Research Centre, University of Manchester,
Manchester, UK.
(3)Centre for Biostatistics, School of Health Sciences, University of Manchester,
Manchester Academic Health Science Centre, Manchester, UK.
(4)Division of Pharmacy and Optometry, School of Health Sciences, Faculty of
Biology, Medicine and Health, University of Manchester, Manchester, UK; Centre
for Pharmacoepidemiology and Drug Safety, Manchester Academic Health Science
Centre, University of Manchester, Manchester, UK.
(5)Division of Musculoskeletal and Dermatological Sciences, Manchester Academic
Health Science Centre and NIHR Manchester Biomedical Research Centre, University
of Manchester, Manchester, UK.
Medication non-adherence is a missed opportunity for therapeutic benefit. We
assessed "real-world" levels of self-reported non-adherence to conventional and
biologic systemic therapies used for psoriasis and evaluated psychological and
biomedical factors associated with non-adherence using multivariable analyses.
Latent profile analysis was used to investigate whether patients can be
categorized into groups with similar medication beliefs. Latent profile analysis
categorizes individuals with similar profiles on a set of continuous variables
into discrete groups represented by a categorical latent variable. Eight hundred
and eleven patients enrolled in the British Association of Dermatologists
Biologic Interventions Register were included. Six hundred and seventeen patients
were using a self-administered systemic therapy; 22.4% were classified as
"non-adherent" (12% intentionally and 10.9% unintentionally). Patients using an
oral conventional systemic agent were more likely to be non-adherent compared to
those using etanercept or adalimumab (29.2% vs. 16.4%; P ≤ 0.001). Latent profile
analysis supported a three-group model; all groups held strong beliefs about
their need for systemic therapy but differed in levels of medication concerns.
Group 1 (26.4% of the sample) reported the strongest concerns, followed by Group
2 (61%), with Group 3 (12.6%) reporting the weakest concerns. Group 1 membership
was associated with intentional non-adherence (odds ratio = 2.27, 95% confidence
interval = 1.16-4.47) and weaker medication-taking routine or habit strength was
associated with unintentional non-adherence (odds ratio = 0.92, 95% confidence
interval = 0.89-0.96). Medication beliefs and habit strength are modifiable
targets for strategies to improve adherence in psoriasis.
Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.jid.2017.11.015
PMCID: PMC5869950
PMID: 29183731 [Indexed for MEDLINE]
Zhang Y(1)(2), Ting RZ(1)(3), Yang W(4), Jia W(5), Li W(6), Ji L(7), Guo X(8),
Kong AP(1)(3), Wing YK(9), Luk AO(1)(2)(3), Sartorius N(10), Morisky DE(11),
Oldenburg B(12), Weng J(13), Chan JC(1)(2)(3); China Depression in Chinese
Patients with Type 2 Diabetes (DD2) Study Group.
Author information:
(1)Department of Medicine and Therapeutics, The Chinese University of Hong Kong,
The Prince of Wales Hospital, Shatin, Hong Kong SAR, China.
(2)Asia Diabetes Foundation, The Chinese University of Hong Kong, The Prince of
Wales Hospital, Shatin, Hong Kong SAR, China.
(3)Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong
Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, China.
(4)Department of Endocrinology and Metabolism, China-Japan Friendship Hospital,
Beijing, China.
(5)Department of Endocrinology and Metabolism, Shanghai Jiao Tong University
Affiliated Sixth People's Hospital, Shanghai, China.
(6)Department of Endocrinology and Metabolism, Peking Union Medical College
Hospital, Beijing, China.
(7)Department of Endocrinology and Metabolism, Peking University People's
Hospital, Beijing, China.
(8)Department of Endocrinology and Metabolism, Peking University First Hospital,
Beijing, China.
(9)Department of Psychiatry, The Chinese University of Hong Kong, Shatin
Hospital, Shatin, Hong Kong SAR, China.
(10)Association for the Improvement of Mental Health Programmes, Geneva,
Switzerland.
(11)University of California Los Angeles Fielding School of Public Health, Los
Angeles, CA, USA.
(12)School of Population and Global Health, The University of Melbourne,
Melbourne, VIC, Australia.
(13)Department of Endocrinology and Metabolism, The Third Affiliated Hospital of
Sun Yat-Sen University, Guangzhou, China.
Comment in
J Diabetes. 2015 Nov;7(6):777-8.
© 2014 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley
Publishing Asia Pty Ltd.
DOI: 10.1111/1753-0407.12238
PMCID: PMC4964948
PMID: 25349949 [Indexed for MEDLINE]
Author information:
(1)School for Public Health and Primary Care (CAPHRI), Department of Health
Services Research, Maastricht University, P.O. Box 616, 6200, Maastricht, MD, The
Netherlands. l.hochstenbach@maastrichtuniversity.nl.
(2)Department of Patient and Care, Maastricht University Medical Center, P.O. Box
5800, 6202, Maastricht, AZ, The Netherlands. a.courtens@mumc.nl.
(3)School for Public Health and Primary Care (CAPHRI), Department of Health
Services Research, Maastricht University, P.O. Box 616, 6200, Maastricht, MD, The
Netherlands. s.zwakhalen@maastrichtuniversity.nl.
(4)School of Health and Social Care, Dept. of Social Work and Health Development,
University of Greenwich, Avery Hill Rd, London, SE9 2UG, UK.
s.zwakhalen@maastrichtuniversity.nl.
(5)Department of Anesthesiology, School for Mental Health and Neuroscience
(MHeNS), Maastricht University Medical Center, P.O. Box 5800, 6202, Maastricht,
AZ, The Netherlands. maarten.van.kleef@mumc.nl.
(6)Department of Anesthesiology, VU University Medical Center, P.O. Box 7057,
1007, Amsterdam, MB, The Netherlands. maarten.van.kleef@mumc.nl.
(7)School for Public Health and Primary Care (CAPHRI), Department of Health
Services Research, Maastricht University, P.O. Box 616, 6200, Maastricht, MD, The
Netherlands. l.dewitte@maastrichtuniversity.nl.
(8)Research Centre Technology in Care, Zuyd University of Applied Sciences, P.O.
Box 550, 6400, Heerlen, AN, The Netherlands. l.dewitte@maastrichtuniversity.nl.
Author information:
(1)Juniper Gardens Children's Project, University of Kansas, 444 Minnesota Ave,
Kansas City, KS 66101.
DOI: 10.1007/s10864-014-9204-x
PMCID: PMC4662407
PMID: 26617453
1465. Prim Care Companion CNS Disord. 2016 Feb 25;18(1). doi: 10.4088/PCC.15m01879.
eCollection 2016.
Author information:
(1)Butler Hospital, Providence, Rhode Island; Alpert Medical School of Brown
University, Providence, Rhode Island.
(2)Department of Psychology, Skidmore College, Saratoga Springs, New York.
(3)McLean Hospital/Harvard Medical School, Belmont, Massachusetts.
DOI: 10.4088/PCC.15m01879
PMCID: PMC4874763
PMID: 27247843 [Indexed for MEDLINE]
Venkatachalam J(1), Abrahm SB(1), Singh Z(1), Stalin P(1), Sathya GR(2).
Author information:
(1)Department of Community Medicine, Pondicherry Institute of Medical Sciences,
Kalapet, Pondicherry, India.
(2)Department of Physiology, Pondicherry Institute of Medical Sciences, Kalapet,
Pondicherry, India.
DOI: 10.4103/0970-0218.149267
PMCID: PMC4317978
PMID: 25657510
Author information:
(1)Department of Anatomical Sciences, School of Medicine, St. George's
University, Grenada, West Indies.
(2)Department of Physiology and Neuroscience, School of Medicine, St. George's
University, Grenada, West Indies.
OBJECTIVE: The goal of this study was to determine the prevalence of asthma in
school children in the tri-island Caribbean nation of Grenada.
SETTING, PARTICIPANTS AND OUTCOMES: This was a self-report study provided to the
guardians of all primary school children between ages 6 and 7 throughout Grenada,
Carriacou and Petite Martinique in 2013. Of the 2362 surveys provided, 1374 were
returned, resulting in a response rate of 58.2%. Only responders listing
birthdays between 1 January 2006 and 31 December 2007 were included in the
analysis, resulting in 1165 qualifying responders. Asthma diagnosis was based on
previous physician diagnosed asthma and/or self-reported presence of wheeze in
the past 12 months (current wheeze). Severity of asthma, medication usage,
environmental exposures, physician and emergency department visits were compared
among respondents.
RESULTS: The prevalence of wheezing in the past year was 30.5±1.8%, and of these
68.4% were previously diagnosed with asthma. Of the current wheeze participants,
39.9±9.2% reported moderate to severe asthma symptoms and increased exposure to
cigarette smoke, excessive dust, burning brush and landfills. Carriacou and
Petite Martinique, the two smaller islands, had a lower incidence of current
wheeze (14.1±7.7%) and exposure rates to cigarette smoke and burning brush as
compared to the larger, denser island of Grenada. Although 65.7% of respondents
diagnosed with asthma reported taking medication, the number of annual doctor and
emergency department visits were high (2.82 and 0.86, respectively). Respondents
with the most severe asthma symptoms reported the most emergency department
visits with an average of 1.05 visits annually, whereas respondents with moderate
asthma symptoms had the most doctor visits with an average of 3.33 visits
annually.
CONCLUSIONS: This study indicates that the prevalence of childhood asthma in
Grenada is very high and warrants policy consideration in public health and
education to decrease its morbidity.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://group.bmj.com/group/rights-licensing/permissions.
DOI: 10.1136/bmjopen-2015-008557
PMCID: PMC4611493
PMID: 26482772 [Indexed for MEDLINE]
Author information:
(1)From the *Unit of Social and Community Psychiatry, Queen Mary University of
London; †Institute of Psychiatry, Psychology and Neuroscience, King's College
London; and ‡Centre for Mental Health, Imperial College London, London, UK.
DOI: 10.1097/JCP.0000000000000276
PMCID: PMC4352071
PMID: 25692797 [Indexed for MEDLINE]
Author information:
(1)Pharmacy and Pharmacogenomics Programs, Manchester University, Fort Wayne, IN,
USA.
(2)Pharmaceutical and Administrative Sciences, Presbyterian College, Clinton, SC,
USA.
Background: As pharmacogenomics (PGx), a component of genetics/genomics and
precision medicine, gains traction in the clinical setting, education of health
care providers and health professions students must be made broadly available to
improve accessibility of such services to patients. As medication experts with
education in pharmacology, pharmacokinetics, and pharmacodynamics, pharmacists
must further their education to include pharmacogenomics. Currently, few
opportunities exist to gain this type of education, and therefore, these services
are not yet broadly available to the public.
Objective: The specific goal of this study was to evaluate pharmacists' and
student pharmacists' self-assessed perception of competence related to genetics,
genomics, and pharmacogenomics as presented via an online "pharmacogenomics
certification program" (PGx program).
Design: The PGx program was delivered online with the content consisting of 3
background lessons and 8 specific drug-gene lessons presented in the context of
pharmacist competency statements. In addition, 11 "video modules" with
competency-related PGx content were included to provide a comprehensive program.
A pre- and post-course survey instrument was used to evaluate the participants'
self-assessed perception of competence related to each of 16 statements.
Results: One hundred thirty-seven (137) individuals enrolled in and completed the
pharmacogenomics certification program. Overall, participants reported
self-perceived improved competency as evidenced by the pre-course survey as
compared with the post-course survey for each of the 16 competency statements
related to genetics/genomics, including pharmacogenomics. Similar results were
observed for the subgroups of student pharmacists (n = 63) and pharmacists
(n = 74).
Future direction: This study showed that dissemination of
genetics/genomics/pharmacogenomics competency statements education can be
accomplished via online delivery. This delivery approach can expand
genetics/genomics/pharmacogenomics content dissemination. The intent is to reach
a broader population of pharmacy students, pharmacists, and other health care
providers and health professions students to potentially advance the availability
of such services, which can improve the safety and efficacy of medication use for
patients.
DOI: 10.1177/2382120519834325
PMCID: PMC6415470
PMID: 30886894
Initial Validation of the HIV Treatment Regimen Fatigue Scale for Adults
Prescribed Antiretroviral Therapy.
DOI: 10.1016/j.jana.2015.01.005
PMCID: PMC4465914
PMID: 26066687 [Indexed for MEDLINE]
Author information:
(1)School of Public Health, The University of Texas Health Science Center at
Houston, Houston, TX.
(2)School of Business, University of Houston Clear Lake, League City, TX.
DOI: 10.1111/1475-6773.12547
PMCID: PMC5517674
PMID: 27558760 [Indexed for MEDLINE]
Author information:
(1)Physical Activity Epidemiology Laboratory, Department of Health, Exercise
Science, and Recreation Management, The University of Mississippi, MS, United
States.
(2)Kevser Ermin Applied Physiology Laboratory, Department of Health, Exercise
Science, and Recreation Management, The University of Mississippi, MS, United
States.
DOI: 10.1016/j.pmedr.2016.03.009
PMCID: PMC4929186
PMID: 27419024
1473. GMS J Med Educ. 2019 Mar 15;36(2):Doc17. doi: 10.3205/zma001225. eCollection
2019.
"Hopefully, I will never forget that again" - sensitizing medical students for
drug safety by working on cases and simulating doctor-patient communication.
Kirsch V(1), Johannsen W(1), Thrien C(2), Herzig S(1)(3), Matthes J(1).
Author information:
(1)Universität zu Köln, Zentrum für Pharmakologie, Köln, Germany.
(2)Universität zu Köln, Medizinische Fakultät, Studiendekanat, Kölner
Interprofessionelles Skills Lab und Simulationszentrum (KISS), Köln, Germany.
(3)Technische Hochschule Köln, Köln, Germany.
Objective: This project is part of the "PJ-STArT-Block", a one-week course
preparing 10th semester medical students for their final practical year. The
focus is on sensitizing students to aspects of medication safety by becoming
aware of their skills and their deficits in terms of application and
communication of pharmacological knowledge. The modules were evaluated regarding
feasibility, acceptance and possible effects. Furthermore, the areas in which
students see their pharmacological deficits or learning successes were gathered.
Methods: In simulated physician-patient conversations, the students are to
identify drug-related problems such as medication errors, adverse drug events or
interactions. Together with their fellow students and under medical or
pharmaceutical moderation, they then have to find solutions for the identified
problems and communicate these solutions to the patients. Based on paper cases,
students practice, reflect, and discuss the research of reliable information
about drugs and medication therapy. The written evaluation included the
evaluation by school grades and the possibility of comments in free text. A
content analysis of interviews with students at the beginning of the project
aimed to identify areas of pharmacology in which they see their own deficits.
Results: Evaluation results including the free text comments indicate students'
acceptance of our pharmacology modules. According to this, the students realize
the importance of aspects relevant for medication safety. The areas mentioned in
35 interviews in which students localize deficits, correspond to the topics that
were intended when conceiving the modules and which are important for medication
safety (e.g. interactions, adverse drug effects, dosages). Conclusion:
Implementation of context-based, application-oriented teaching formats as
recently claimed for pharmacological education to improve the quality of
prescriptions, is possible, as the Cologne example shows. The student evaluation
turns out positively and indicates a critical self-reflection. The students
identified various pharmacological deficits in themselves, which have since been
confirmed and quantified in another study.
Conflict of interest statement: The authors declare that they have no competing
interests.
Angermeyer MC(1)(2), van der Auwera S(3), Carta MG(2), Schomerus G(3).
Author information:
(1)Center for Public Mental Health, Gösing am Wagram, Austria.
(2)Department of Public Health, Clinical and Molecular Medicine, University of
Cagliari, Cagliari, Italy.
(3)Department of Psychiatry and Psychotherapy, University of Greifswald,
Greifswald, Germany.
DOI: 10.1002/wps.20383
PMCID: PMC5269489
PMID: 28127931
1475. Obstet Gynecol Sci. 2015 Nov;58(6):507-13. doi: 10.5468/ogs.2015.58.6.507.
Epub
2015 Nov 16.
Author information:
(1)Department of Obstetrics and Gynecology, Kyung Hee University Hospital, Seoul,
Korea.
(2)Department of Obstetrics and Gynecology, Kyung Hee University Hospital at
Gangdong, Kyung Hee University College of Medicine, Seoul, Korea.
(3)Department of Statistics, Sungkyunkwan University, Seoul, Korea.
DOI: 10.5468/ogs.2015.58.6.507
PMCID: PMC4663230
PMID: 26623416
Taylor CL(1)(2), van Ravesteyn LM(3), van denBerg MP(3)(4), Stewart RJ(5), Howard
LM(6).
Author information:
(1)Department of Health Services and Population Research, Institute of
Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
clare.l.taylor@kcl.ac.uk.
(2)Section of Women's Mental Health, PO31 Institute of Psychiatry, Psychology &
Neuroscience, King's College London, De Crespigny Park, SE5 8AF, London, UK.
clare.l.taylor@kcl.ac.uk.
(3)Department of Psychiatry, Erasmus University Medical Center, Rotterdam, The
Netherlands.
(4)Department of Child & Adolescent Psychiatry, Erasmus University Medical
Center, Rotterdam, The Netherlands.
(5)Department of Psychological Medicine, Institute of Psychiatry, Psychology and
Neuroscience, King's College London, London, UK.
(6)Department of Health Services and Population Research, Institute of
Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Women with severe mental illness are at increased risk of suicide in the
perinatal period, and these suicides are often preceded by self-harm, but little
is known about self-harm and its correlates in this population. This study aimed
to investigate the prevalence of suicidal ideation and self-harm, and its
correlates, in women with psychotic disorders and bipolar disorder during
pregnancy. Historical cohort study using de-identified secondary mental
healthcare records linked with national maternity data. Women pregnant from 2007
to 2011, with ICD-10 diagnoses of schizophrenia and related disorders, bipolar
disorder or other affective psychoses were identified. Data were extracted from
structured fields, natural language processing applications and free text.
Logistic regression was used to examine the correlates of self-harm in pregnancy.
Of 420 women, 103 (24.5 %) had a record of suicidal ideation during the first
index pregnancy, with self-harm recorded in 33 (7.9 %). Self-harm was
independently associated with younger age (adjusted odds ratio (aOR) 0.91, 95 %
CI 0.85-0.98), self-harm in the previous 2 years (aOR 2.55; 1.05-6.50) and
smoking (aOR 3.64; 1.30-10.19). A higher prevalence of self-harm was observed in
women with non-affective psychosis, those who discontinued or switched medication
and in women on no medication at the start of pregnancy, but these findings were
not statistically significant in multivariable analyses. Suicidal thoughts and
self-harm occur in a significant proportion of pregnant women with severe mental
illness, particularly younger women and those with a history of self-harm; these
women need particularly close monitoring for suicidality.
DOI: 10.1007/s00737-016-0636-2
PMCID: PMC5021774
PMID: 27173485 [Indexed for MEDLINE]
Conflict of interest statement: This study has been part-funded by the Johnson &
Johnson CSR Citizenship Trust. Johnson & Johnson had no involvement in the design
of the study or access to any data throughout the project. RS and MB have
received research funding from the Pfizer, J&J, Lundbeck and Roche. Funding This
report was independent research, part funded by Tommy’s Charity through Johnson &
Johnson CSR Citizenship Trust. Johnson & Johnson had no involvement in the design
of the study or access to any data. Part funding was also obtained from the NIHR
Biomedical Research Centre informatics facility at South London and Maudsley NHS
Foundation Trust, London, UK, a National Institute for Health Research
Professorship for Louise Howard (NIHR-RP-R3-12-011); RS is part-funded by the
National Institute for Health Research (NIHR) Biomedical Research Centre at South
London and Maudsley NHS Foundation Trust and King’s College London and LvR is
part-funded by Erasmus University Medical Center (MRACE) and the Coolsingel
Foundation. The views expressed in this publication are those of the author(s)
and not necessarily those of the NHS, the National Institute for Health Research
or the Department of Health.
Author information:
(1)Department of Preventive and Social Medicine, University of Port Harcourt,
Port Harcourt, Nigeria.
DOI: 10.4103/1596-3519.149879
PMID: 26021398 [Indexed for MEDLINE]
Levin JB(1), Sams J(2), Tatsuoka C(3), Cassidy KA(2), Sajatovic M(2).
Author information:
(1)Department of Psychiatry, Case Western Reserve University School of Medicine,
10524 Euclid Avenue, Cleveland, OH, 44106 USA.
(2)Department of Psychiatry, Case Western Reserve University School of Medicine,
Cleveland, OH, USA.
(3)Neurological and Behavioral Outcomes Center, University Hospitals Case Medical
Center, Cleveland, OH, USA.
DOI: 10.1177/2045125314566807
PMCID: PMC4521443
PMID: 26240747
Author information:
(1)Nursing Care Research Center, School of Nursing and Midwifery,Iran.
(2)Iran University of Medical Sciences, Tehran, Iran.
(3)Iranian Centres for Communicable Disease Control (CDC).
(4)Ministry of Health and Medical Education (MOHME), Iran.
DOI: 10.11604/pamj.2017.28.231.12385
PMCID: PMC5882209
PMID: 29629017 [Indexed for MEDLINE]
Downs J(1), Hotopf M(2), Ford T(2)(3), Simonoff E(2), Jackson RG(2)(4), Shetty
H(4), Stewart R(2)(4), Hayes RD(2).
Author information:
(1)Institute of Psychiatry, Psychology and Neuroscience, King's College London,
De Crespigny Park, Box 63, SE5 8AF, London, UK. johnny.downs@kcl.ac.uk.
(2)Institute of Psychiatry, Psychology and Neuroscience, King's College London,
De Crespigny Park, Box 63, SE5 8AF, London, UK.
(3)University of Exeter Medical School, Exeter, UK.
(4)South London and Maudsley NHS Foundation Trust, London, UK.
Children with autism spectrum disorders (ASD) are more likely to receive
antipsychotics than any other psychopharmacological medication, yet the
psychiatric disorders and symptoms associated with treatment are unclear. We
aimed to determine the predictors of antipsychotic use in children with ASD
receiving psychiatric care. The sample consisted of 3482 children aged 3-17 with
an ICD-10 diagnosis of ASD referred to mental health services between 2008 and
2013. Antipsychotic use outcome, comorbid diagnoses, and other clinical
covariates, including challenging behaviours were extracted from anonymised
patient records. Of the 3482 children (79 % male) with ASD, 348 (10 %) received
antipsychotic medication. The fully adjusted model indicated that comorbid
diagnoses including hyperkinetic (OR 1.44, 95 %CI 1.01-2.06), psychotic (5.71,
3.3-10.6), depressive (2.36, 1.37-4.09), obsessive-compulsive (2.31, 1.16-4.61)
and tic disorders (2.76, 1.09-6.95) were associated with antipsychotic use. In
addition, clinician-rated levels of aggression, self-injurious behaviours,
reduced adaptive function, and overall parental concern for their child's
presenting symptoms were significant risk factors for later antipsychotic use. In
ASD, a number of comorbid psychiatric disorders are independent predictors for
antipsychotic treatment, even after adjustment for familial, socio-demographic
and individual factors. As current trial evidence excludes children with
comorbidity, more pragmatic randomised controlled trials with long-term drug
monitoring are needed.
DOI: 10.1007/s00787-015-0780-7
PMCID: PMC4889626
PMID: 26472118 [Indexed for MEDLINE]
A new brief opioid stigma scale to assess perceived public attitudes and
internalized stigma: Evidence for construct validity.
Yang LH(1), Grivel MM(2), Anderson B(3), Bailey GL(4), Opler M(5), Wong LY(6),
Stein MD(7).
Author information:
(1)Department of Social and Behavioral Sciences, College of Global Public Health,
New York University, NY, USA; Department of Epidemiology, Mailman School of
Public Health, Columbia University, NY, USA. Electronic address: Ly1067@nyu.edu.
(2)Department of Social and Behavioral Sciences, College of Global Public Health,
New York University, NY, USA.
(3)Butler Hospital, Providence, RI, USA.
(4)Department of Psychiatry and Human Behavior, Warren Alpert Medical School,
Brown University, Providence, RI, USA; Stanley Street Treatment & Resources,
Inc., Fall River, MA, USA.
(5)MedAvante-ProPhase Inc., USA.
(6)City College of New York, NY, USA.
(7)Butler Hospital, Providence, RI, USA; Boston University School of Public
Health, Boston, MA, USA.
One key strategy to improve treatment access for persons with opioid use disorder
(OUD) is overcoming stigma that is internalized by such individuals. Because few
theoretically-derived, multidimensional measures of substance abuse stigma exist,
we contribute a brief, theoretically-based measure of opioid-related stigma
(adapted from Corrigan's Self-Stigma of Mental Illness Scale) to assess perceived
stigma and internalized stigma among individuals with OUD. This study presents
initial validation of the newly-developed Brief Opioid Stigma Scale among 387
adults who entered an inpatient opioid managed-withdrawal program. The scale
assesses: (1) Stereotype awareness ("Aware"), or the extent to which individuals
who use opioids perceive community members to believe OUD-related stereotypes;
(2) Stereotype agreement ("Agree"), or the endorsement of stigmatizing beliefs by
individuals who use opioids; (3) Self-esteem decrement ("Harm"), or the
diminution of self-esteem due to these negative stereotypes' impacts on
self-worth. Psychosocial measures including self-esteem, depressive symptoms,
mental and physical functioning, and desire for aftercare OUD medication
treatment, were administered to assess construct validity. Results showed that
greater endorsement of the "harm" stigma subscale was associated with greater
depressive symptoms, lower self-esteem, and poorer mental and physical
functioning. The "aware" stigma subscale displayed similar overall patterns of
associations with self-esteem and depression but to a lesser magnitude. The
"aware" stigma subscale was positively associated with desire for aftercare
methadone and naltrexone treatment, and the "harm" subscale was positively
associated with desire for aftercare buprenorphine treatment. Results indicated
good initial construct validity. Tailored stigma interventions are recommended
for specific aftercare OUD medication treatments.
DOI: 10.1016/j.jsat.2019.01.005
PMCID: PMC6716158
PMID: 30797393
Pinnock H(1).
Author information:
(1)Asthma UK Centre for Applied Research, Usher Institute of Population Health
Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
DOI: 10.1183/20734735.015614
PMCID: PMC4487370
PMID: 26306110
Author information:
(1)International Centre for Allied Health Evidence, Sansom Institute for Health
Research, University of South Australia (City East), North Tce, Adelaide, SA,
Australia, 5000.
Comment in
Int J Nurs Pract. 2018 Apr;24(2):e12612.
BACKGROUND: Stroke results from an acute lack of blood supply to the brain and
becomes a chronic health condition for millions of survivors around the world.
Self management can offer stroke survivors a pathway to promote their recovery.
Self management programmes for people with stroke can include specific education
about the stroke and likely effects but essentially, also focusses on skills
training to encourage people to take an active part in their management. Such
skills training can include problem-solving, goal-setting, decision-making, and
coping skills.
OBJECTIVES: To assess the effects of self management interventions on the quality
of life of adults with stroke who are living in the community, compared with
inactive or active (usual care) control interventions.
SEARCH METHODS: We searched the following databases from inception to April 2016:
the Cochrane Stroke Group Trials Register, Cochrane Central Register of
Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL, PsycINFO, SCOPUS, Web of
Science, OTSeeker, OT Search, PEDro, REHABDATA, and DARE. We also searched the
following trial registries: ClinicalTrials.gov, Stroke Trials Registry, Current
Controlled Trials, World Health Organization, and Australian New Zealand Clinical
Trials Registry.
SELECTION CRITERIA: We included randomised controlled trials of adults with
stroke living in the community who received self management interventions. These
interventions included more than one component of self management or targeted
more than a single domain of change, or both. Interventions were compared with
either an inactive control (waiting list or usual care) or active control
(alternate intervention such as education only). Measured outcomes included
changes in quality of life, self efficacy, activity or participation levels,
impairments, health service usage, health behaviours (such as medication
adherence or lifestyle behaviours), cost, participant satisfaction, or adverse
events.
DATA COLLECTION AND ANALYSIS: Two review authors independently extracted
prespecified data from all included studies and assessed trial quality and risk
of bias. We performed meta-analyses where possible to pool results.
MAIN RESULTS: We included 14 trials with 1863 participants. Evidence from six
studies showed that self management programmes improved quality of life in people
with stroke (standardised mean difference (SMD) random effects 0.34, 95%
confidence interval (CI) 0.05 to 0.62, P = 0.02; moderate quality evidence) and
improved self efficacy (SMD, random effects 0.33, 95% CI 0.04 to 0.61, P = 0.03;
low quality evidence) compared with usual care. Individual studies reported
benefits for health-related behaviours such as reduced use of health services,
smoking, and alcohol intake, as well as improved diet and attitude. However,
there was no superior effect for such programmes in the domains of locus of
control, activities of daily living, medication adherence, participation, or
mood. Statistical heterogeneity was mostly low; however, there was much variation
in the types and delivery of programmes. Risk of bias was relatively low for
complex intervention clinical trials where participants and personnel could not
be blinded.
AUTHORS' CONCLUSIONS: The current evidence indicates that self management
programmes may benefit people with stroke who are living in the community. The
benefits of such programmes lie in improved quality of life and self efficacy.
These are all well-recognised goals for people after stroke. There is evidence
for many modes of delivery and examples of tailoring content to the target group.
Leaders were usually professionals but peers (stroke survivors and carers) were
also reported - the commonality is being trained and expert in stroke and its
consequences. It would be beneficial for further research to be focused on
identifying key features of effective self management programmes and assessing
their cost-effectiveness.
DOI: 10.1002/14651858.CD010442.pub2
PMCID: PMC6450423
PMID: 27545611 [Indexed for MEDLINE]
Herrmann ES(1), Cooper ZD(2), Bedi G(2), Ramesh D(2), Reed SC(2), Comer SD(2),
Foltin RW(2), Haney M(2).
Author information:
(1)Division on Substance Abuse, New York State Psychiatric Institute, Department
of Psychiatry, Columbia University Medical Center, New York, NY, USA.
herrman@nyspi.columbia.edu.
(2)Division on Substance Abuse, New York State Psychiatric Institute, Department
of Psychiatry, Columbia University Medical Center, New York, NY, USA.
RATIONALE: Each year, over 300,000 individuals in the USA enter treatment for
cannabis use disorder (CUD). The development of effective pharmacotherapy for CUD
is a priority.
OBJECTIVE: This placebo-controlled study examined the effects of zolpidem alone
and in combination with nabilone on cannabis withdrawal and a laboratory measure
of relapse.
METHODS: Eleven daily, non-treatment-seeking cannabis users completed three,
8-day inpatient phases; each phase tested a different medication condition in
counter-balanced order. On the first day of each phase, participants were
administered placebo capsules t.i.d. and smoked experimenter-administered active
cannabis (5.6 % Δ(9)-tetrahydrocannabinol (THC)). On days 2-8, the participants
were administered capsules containing either placebo (0 mg at 0900, 1800, and
2300 hours), zolpidem (0 mg at 0900 and 1800, and 12.5 mg at 2300), or zolpidem
(12.5 mg at 2300) and nabilone (3 mg at 0900 and 1800). Cannabis withdrawal,
subjective capsule effects, and cognitive performance were examined on days 3-4,
when only inactive cannabis (0.0 % THC) was available for self-administration.
"Relapse" was measured on days 5-8, when participants could self-administer
active cannabis.
RESULTS: Both medication conditions decreased withdrawal-related disruptions in
sleep, but only zolpidem in combination with nabilone decreased
withdrawal-related disruptions in mood and food intake relative to placebo.
Zolpidem in combination with nabilone, but not zolpidem alone, decreased
self-administration of active cannabis. Zolpidem in combination with nabilone
also produced small increases in certain abuse-related subjective capsule
ratings, while zolpidem alone did not. Neither medication condition altered
cognitive performance.
CONCLUSIONS: Clinical testing of nabilone, either alone, or in combination with
zolpidem is warranted.
DOI: 10.1007/s00213-016-4298-6
PMCID: PMC5302052
PMID: 27085870 [Indexed for MEDLINE]
Author information:
(1)Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
katie.weinger@joslin.harvard.edu.
(2)Ohio University Heritage College of Osteopathic Medicine, Athens, USA.
(3)Columbia University School of Nursing, New York, NY, USA.
DOI: 10.1177/0193945914521696
PMCID: PMC4125543
PMID: 24510969 [Indexed for MEDLINE]
1486. J Clin Med Res. 2019 Aug;11(8):583-592. doi: 10.14740/jocmr3894. Epub 2019
Jul
27.
Author information:
(1)Department of Internal Medicine, Centro Hospitalar Universitario S. Joao
(CHUSJ), Porto, Portugal.
(2)Center for Health Technology and Services Research (CINTESIS), Faculty of
Medicine, University of Porto (FMUP), Portugal.
(3)Department of Clinical Neurosciences and Mental Health, Faculty of Medicine,
University of Porto (FMUP), Portugal.
(4)Clinic of Psychiatry and Mental Health, Centro Hospitalar Universitario S.
Joao (CHUSJ), Porto, Portugal.
DOI: 10.14740/jocmr3894
PMCID: PMC6681861
PMID: 31413770
Author information:
(1)Global Noncommunicable Diseases Branch, Division of Global Health Protection,
Center for Global Health, Centers for Disease Control and Prevention, Atlanta,
GA, USA. BDatta@cdc.gov.
(2)Global Noncommunicable Diseases Branch, Division of Global Health Protection,
Center for Global Health, Centers for Disease Control and Prevention, Atlanta,
GA, USA.
(3)Health Metrics and Measurement Cluster, World Health Organization, Geneva,
Switzerland.
DOI: 10.1186/s12939-018-0906-x
PMCID: PMC6334430
PMID: 30646905 [Indexed for MEDLINE]
© 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics
Society.
DOI: 10.1111/jgs.14166
PMCID: PMC5295838
PMID: 27321598 [Indexed for MEDLINE]
Conflict of interest statement: The editor in chief has reviewed the conflict of
interest checklist provided by the authors and has determined that the authors
have no financial or any other kind of personal conflicts with this paper.
Shiyanbola OO(1), Walbrandt Pigarelli DL(2), Unni EJ(3), Smith PD(4), Maurer
MA(5), Huang YM(1).
Author information:
(1)Division of Social and Administrative Sciences, School of Pharmacy, University
of Wisconsin-Madison, WI, USA.
(2)Division of Pharmacy Practice, School of Pharmacy, University of
Wisconsin-Madison, WI, USA.
(3)Department of Pharmaceutical Sciences, College of Pharmacy, Roseman University
of Health Sciences, Utah, USA.
(4)Department of Family Medicine and Community Health, School of Medicine and
Public Health, University of Wisconsin-Madison, WI, USA.
(5)Sonderegger Research Center, School of Pharmacy, University of
Wisconsin-Madison, WI, USA.
DOI: 10.1016/j.conctc.2019.100326
PMCID: PMC6348197
PMID: 30705995
Author information:
(1)Psychological Sciences, University of Connecticut, Storrs, CT, 06268, USA.
(2)Department of Statistics, University of Connecticut, Storrs, CT, USA.
(3)Psychological Sciences, University of Connecticut, Storrs, CT, 06268, USA.
seth.k@uconn.edu.
DOI: 10.1007/s12160-016-9827-3
PMCID: PMC5253105
PMID: 27510955 [Indexed for MEDLINE]
Author information:
(1)University of Missouri, Columbia, MO, USA enriquezm@missouri.edu.
(2)University of Missouri, Columbia, MO, USA.
DOI: 10.1177/2150131915601794
PMCID: PMC5695224
PMID: 26303976 [Indexed for MEDLINE]
Synergistic effects of food insecurity and drug use on medication adherence among
people living with HIV infection.
Author information:
(1)Department of Psychology, University of Connecticut, 406 Babbidge Road, Unit
1020, Storrs, CT, 06269, USA, star.chen@uconn.edu.
Food insecurity and drug use are closely connected in the context of poverty, and
both have been suggested to interfere with HIV medication adherence among people
living with HIV/AIDS (PLWH). Yet the potential interaction between the two
factors on adherence has not been examined. For this study we collected
longitudinal data on HIV medication adherence among PLWH in Atlanta, GA, to
assess a possible synergistic effect between the two factors on HIV medication
adherence. People informed about the study came to the research site and
completed an audio computer-assisted self-interview and instructions for pill
counting. Over the next 5 weeks participants received three unscheduled follow-up
phone assessments conducted 2 weeks apart to collect pill counts of their HIV
medication. The prevalence of food insecurity was 60 % (488) and that of drug use
was 33 % (274) in the sample of 809 participants. Among 770 participants who
completed follow-up phone assessments, both food insecurity and drug use were
associated with HIV medication adherence after adjusting for socio-demographic
characteristics. The negative association between drug use and adherence
persisted after further adjusting for health-related characteristics. Moreover,
drug use appeared to moderate the effect of food insufficiency on adherence, with
drug users who were food insufficient being the least likely to achieve 85 %
adherence. Results from the current study demonstrate a synergism between food
insecurity and drug use that may impede adherence among PLWH. The findings imply
that the disruptive effects of food insecurity and drug use on adherence are
likely to be intensified with the presence of each other, and encourage
interventions to address the problem of HIV medication adherence from a
multi-faceted perspective that takes into account detrimental combination of
problem factors.
DOI: 10.1007/s10865-014-9612-3
PMCID: PMC4425576
PMID: 25533641 [Indexed for MEDLINE]
Author information:
(1)Graduate Institute of Medical Sciences, National Defense Medical Center,
Taipei.
(2)Chung-Jen Junior College of Nursing, Health Sciences and Management, Chiayi.
(3)Department of Nursing, Tri-Service General Hospital.
(4)School of Nursing, National Defense Medical Center.
(5)Department of Internal Medicine, Division of Cardiology, Tri-Service General
Hospital.
(6)School of Medicine, National Defense Medical Center.
(7)Department of Mathematics, Tamkang University, Taipei, Taiwan.
BACKGROUND: Medication titration has been used in home blood pressure (BP)
control, with the expectation of enabling patients with hypertension to better
manage their BP.
OBJECTIVE: The study goal was to estimate the effects of medication titration
intervention in lowering the systolic blood pressure and diastolic blood pressure
of patients with hypertension.
METHODS: The meta-analysis included randomized controlled trials on adults
diagnosed with hypertension and BP≧130/80 mm Hg, having a medication-titration
intervention, and using a home BP measurement. We systematically searched PubMed,
CINAHL, Ovid-Medline, and the Cochrane Library, for studies published from 1997
to 2017. The quality of the studies was evaluated by the Modified Jadad scale.
Statistical heterogeneity among the trials was evaluated using Q statistics and
I. Publication bias was assessed with the funnel plot and Rosenthal's fail-safe
N.
RESULTS: The meta-analysis included 4 studies randomizing 1335 participants.
Medication-titration intervention significantly assisted hypertensive patients to
improve BP control; systolic blood pressure was reduced by 6.86 mm Hg [95%
confidence interval (CI), 4.80-8.93, P<0.0001] and diastolic blood pressure by
3.03 mm Hg (95% CI, 2.07-3.99, P<0.0001), did not significantly affect EQ-5D
scores (mean difference, 0.02; 95% CI, -0.01 to 0.04, P=0.13).
CONCLUSIONS: Our findings suggest home medication titration of antihypertensive
medication for hypertensive patients significantly improved home BP control.
However, the strategy did not enhance quality of life in patients with
hypertension.
DOI: 10.1097/MLR.0000000000001064
PMCID: PMC6410972
PMID: 30762831 [Indexed for MEDLINE]
Author information:
(1)Programa de Pós-Graduação em Assistência Farmacêutica, Faculdade de Farmácia,
Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
(2)Serviço de Farmácia, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS,
Brazil.
DOI: 10.31744/einstein_journal/2018AO4212
PMCID: PMC6223948
PMID: 30427481 [Indexed for MEDLINE]
Tompson A(1), Heneghan C(1), Sutton S(2), Fitzmaurice D(3), Ward A(1).
Author information:
(1)Nuffield Department of Primary Care Health Sciences, University of Oxford,
Oxford, UK.
(2)Institute of Public Health, University of Cambridge, Cambridge, UK.
(3)Primary Care Clinical Sciences, University of Birmingham, Birmingham, UK.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://www.bmj.com/company/products-services/rights-and-licensing/.
DOI: 10.1136/bmjopen-2016-013123
PMCID: PMC5223672
PMID: 28011812 [Indexed for MEDLINE]
1496. J Pharm Health Care Sci. 2019 Jan 10;5:1. doi: 10.1186/s40780-019-0131-9.
eCollection 2019.
Author information:
(1)Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti
Sains Malaysia, Pinang, Malaysia.
DOI: 10.1186/s40780-019-0131-9
PMCID: PMC6327512
PMID: 30652009
Author information:
(1)1 University of Utah, Salt Lake City, UT, USA.
(2)3 Department of Pharmacy Practice and Pharmaceutical Sciences, University of
Minnesota, College of Pharmacy, Duluth, MN, USA.
(3)2 Primary Children's Hospital, Salt Lake City, UT, USA.
DOI: 10.1177/1043454217741877
PMCID: PMC5935503
PMID: 29188741
Jäger C(1), Freund T(2), Steinhäuser J(3), Stock C(4), Krisam J(4),
Kaufmann-Kolle P(5), Wensing M(2), Szecsenyi J(2).
Author information:
(1)Department of General Practice and Health Services Research, University
Hospital Heidelberg, Im Neuenheimer Feld 130.3, Turm West, 4.OG, 69120,
Heidelberg, Germany. cornelia.jaeger@med.uni-heidelberg.de.
(2)Department of General Practice and Health Services Research, University
Hospital Heidelberg, Im Neuenheimer Feld 130.3, Turm West, 4.OG, 69120,
Heidelberg, Germany.
(3)Institute of Family Medicine, UniversityHospital Schleswig-Holstein, Campus
Lübeck, Ratzburger Allee 160, Haus 50, 23538, Lübeck, Germany.
(4)Department of Medical Biometry, Institute of Medical Biometry and Informatics,
University Hospital Heidelberg, Im Neuenheimer Feld 130.3, Turm West, 12.OG,
69120, Heidelberg, Germany.
(5)Institute for Applied Quality Improvement and Research in Health Care GmbH,
(AQUA-Institute), Maschmühlenweg 8-10, 37073, Göttingen, Germany.
DOI: 10.1186/s13012-016-0535-y
PMCID: PMC5237147
PMID: 28086976 [Indexed for MEDLINE]
1499. Int J Environ Res Public Health. 2017 Aug 12;14(8). pii: E910. doi:
10.3390/ijerph14080910.
Ji M(1), Zhang Y(2), Zou J(3), Yuan T(4), Tang A(5), Deng J(6), Yang L(7), Li
M(8), Chen J(9), Qin H(10), Lin Q(11).
Author information:
(1)Department of Nutrition Science and Food Hygiene, Xiangya School of Public
Health, Central South University, 110 Xiangya Road, Changsha 410078, Hunan,
China. jimeimei1024@foxmail.com.
(2)Department of Nutrition Science and Food Hygiene, Xiangya School of Public
Health, Central South University, 110 Xiangya Road, Changsha 410078, Hunan,
China. yefuzhang@foxmail.com.
(3)Department of Nutrition Science and Food Hygiene, Xiangya School of Public
Health, Central South University, 110 Xiangya Road, Changsha 410078, Hunan,
China. zjj170605@foxmail.com.
(4)Department of Nutrition Science and Food Hygiene, Xiangya School of Public
Health, Central South University, 110 Xiangya Road, Changsha 410078, Hunan,
China. yuantong168@foxmali.com.
(5)Department of Molecular, Cellular and Developmental Biology, Yale University,
219 Prospect St, New Haven, CT 06511, USA. amber.tang@yale.edu.
(6)Department of Epidemiology and Statistical Science, Xiangya School of Public
Health, Central South University, 110 Xiangya Road, Changsha 410078, Hunan,
China. dengjing2@126.com.
(7)Department of Nutrition Science and Food Hygiene, Xiangya School of Public
Health, Central South University, 110 Xiangya Road, Changsha 410078, Hunan,
China. ylnly1997@csu.edu.cn.
(8)Department of Nutrition Science and Food Hygiene, Xiangya School of Public
Health, Central South University, 110 Xiangya Road, Changsha 410078, Hunan,
China. lmz1976@126.com.
(9)Department of Nutrition Science and Food Hygiene, Xiangya School of Public
Health, Central South University, 110 Xiangya Road, Changsha 410078, Hunan,
China. chenjh@csu.edu.cn.
(10)Department of Nutrition Science and Food Hygiene, Xiangya School of Public
Health, Central South University, 110 Xiangya Road, Changsha 410078, Hunan,
China. qinhong@csu.edu.cn.
(11)Department of Nutrition Science and Food Hygiene, Xiangya School of Public
Health, Central South University, 110 Xiangya Road, Changsha 410078, Hunan,
China. linqian@csu.edu.cn.
DOI: 10.3390/ijerph14080910
PMCID: PMC5580613
PMID: 28805702 [Indexed for MEDLINE]
Health coaching for glaucoma care: a pilot study using mixed methods.
Author information:
(1)Department of Ophthalmology, Duke University, Durham, NC, USA.
(2)Department of Health Philosophy and Promotion, Maryland University of
Integrative Health, Laurel, MD, USA.
(3)Department of Ophthalmology, Duke University, Durham, NC, USA ; Durham VA
Medical Center, Durham, NC, USA.
Risk factors for cost-related medication non-adherence among older patients with
diabetes.
Author information:
(1)James X Zhang, Jhee U Lee, David O Meltzer, Section of Hospital Medicine,
Department of Medicine, the University of Chicago, Chicago, IL 60637, United
States.
AIM: To assess the risk factors for cost-related medication non-adherence (CRN)
among older patients with diabetes in the United States.
METHODS: We used data from the 2010 Health and Retirement Study to assess risk
factors for CRN including age, drug insurance coverage, nursing home residence,
functional limitations, and frequency of hospitalization. CRN was self-reported.
We conducted multivariate regression analysis to assess the effect of each risk
factor.
RESULTS: Eight hundred and seventy-five (18%) of 4880 diabetes patients reported
CRN. Age less than 65 years, lack of drug insurance coverage, and frequent
hospitalization significantly increased risk for CRN. Limitation in both
activities of daily living and instrumental activities of daily living were also
generally associated with increased risk of CRN. Residence in a nursing home and
Medicaid coverage significantly reduced risk.
CONCLUSION: These results suggest that expanding prescription coverage to
uninsured, sicker, and community-dwelling individuals is likely to produce the
largest decreases in CRN.
DOI: 10.4239/wjd.v5.i6.945
PMCID: PMC4265885
PMID: 25512801
Author information:
(1)a School of Social Work , University of North Carolina at Chapel Hill , Chapel
Hill , North Carolina , USA.
(2)b Global Social Development Innovations , University of North Carolina at
Chapel Hill , Chapel Hill , North Carolina , USA.
In Zambia, more people living with HIV now have access to lifesaving
antiretroviral therapy than ever before. However, progress in HIV treatment and
care has not always resulted in lower mortality. Adherence remains a critical
barrier to treatment success. The objective of this study was to examine the
barriers and facilitators of antiretroviral therapy adherence, particularly the
role of household economic status. The study included a cross-sectional sample of
101 people living with HIV (PLHIV) in two rural communities in eastern Zambia.
Adherence was measured using patient self-assessment and pharmacy information.
Household economic status included components such as occupation, income, assets,
food security, and debt. Multivariable logistic regression was conducted to
examine the associations between household economic factors and adherence. Our
findings suggest that the role of economic status on adherence appears to be a
function of the economic component. Debt and non-farming-related occupation were
consistently associated with non-adherence. The association between assets and
adherence depends on the type of asset. Owning more transportation-related assets
was consistently associated with non-adherence, whereas owning more livestock was
associated with self-reported adherence. Additionally, living in a community with
fewer economic opportunities was associated with non-adherence. The associations
between place of residence and pharmacy refill adherence and between
transportation assets and self-reported adherence were statistically significant.
Improving adherence requires a multifaceted strategy that addresses the role of
economic status as a potential barrier and facilitator. Programmes that provide
economic opportunities and life-skills training may help PLHIV to overcome
economic, social, and psychological barriers.
DOI: 10.2989/16085906.2017.1308386
PMCID: PMC5963730
PMID: 28639469 [Indexed for MEDLINE]
Author information:
(1)Merck & Co., Whitehouse Station, NJ 08889, USA.
(2)Kantar Health, 20121 Milan, Italy.
DOI: 10.1155/2015/607148
PMCID: PMC4689974
PMID: 26783470
Relation between health literacy, self-care and adherence to treatment with oral
anticoagulants in adults: a narrative systematic review.
Author information:
(1)Unidad de cuidados intensivos, Hospital Universitario y politécnico La Fe,
Valencia, Spain.
(2)Nursing Department, University of Valencia, Valencia, Spain.
(3)NIHR Health Protection Research Unit in Healthcare Associated Infection and
Antimicrobial Resistance at Imperial College London, Du Cane Road, W12 0NN,
London, UK. e.castro-sanchez@imperial.ac.uk.
(4)Department of Nursing Science, Faculty of Health Sciences, University of
Eastern Finland, Kuopio, Finland.
(5)Universidad San Jorge de Zaragoza, Villanueva de Gállego, Zaragoza, Spain.
(6)Escuela de Enfermería La Fe, centro adscrito Universidad de Valencia,
Valencia, Spain.
(7)Instituto de Investigación La Fe. Grupo de investigación GREIACC, Valencia,
Spain.
DOI: 10.1186/s12889-018-6070-9
PMCID: PMC6172776
PMID: 30286744 [Indexed for MEDLINE]
Waller K(1), Furber S(2), Bauman A(3), Allman-Farinelli M(3), van den Dolder
P(2), Hayes A(3), Facci F(2), Franco L(2), Webb A(2), Moses R(2), Colagiuri S(3).
Author information:
(1)Illawarra Shoalhaven Local Health District, Warrawong, Australia.
karen.waller@health.nsw.gov.au.
(2)Illawarra Shoalhaven Local Health District, Warrawong, Australia.
(3)University of Sydney, Sydney, Australia.
DOI: 10.1186/s12889-019-6550-6
PMCID: PMC6399841
PMID: 30832638 [Indexed for MEDLINE]
Blalock SJ(1), DeVellis RF(2), Chewning B(3), Sleath BL(4), Reyna VF(5).
Author information:
(1)Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy, University of
North Carolina at Chapel Hill, USA. Electronic address: s_blalock@unc.edu.
(2)Health Behavior, Gillings Global School of Public Health, University of North
Carolina at Chapel Hill, USA.
(3)Social and Administrative Sciences Division, School of Pharmacy, University of
Wisconsin-Madison, USA.
(4)Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy, University of
North Carolina at Chapel Hill, USA.
(5)Human Neuroscience Institute, Cornell University, Ithaca, NY 14853, USA.
DOI: 10.1016/j.pec.2015.12.001
PMCID: PMC5511622
PMID: 26786667 [Indexed for MEDLINE]
High relapse rate and poor medication adherence in the Chinese population with
schizophrenia: results from an observational survey in the People's Republic of
China.
Author information:
(1)Department of Psychiatry, Peking University Sixth Hospital, Peking University
Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Health,
Peking University, Beijing, People's Republic of China.
DOI: 10.2147/NDT.S72367
PMCID: PMC4431492
PMID: 26056450
1509. AMIA Annu Symp Proc. 2018 Apr 16;2017:1893-1902. eCollection 2017.
Author information:
(1)University of California San Diego, San Diego, CA.
As of 2014, 29.1 million people in the US have diabetes. Patients with diabetes
have evolving information needs around complex lifestyle and medical decisions.
As their conditions progress, patients need to sporadically make decisions by
understanding alternatives and comparing options. These moments along the
decision-making process present a valuable opportunity to support their
information needs. An increasing number of patients visit online diabetes
communities to fulfill their information needs. To understand how patients
attempt to fulfill the information needs around decision-making in online
communities, we reviewed 801 posts from an online diabetes community and included
79 posts for in-depth content analysis. The findings revealed motivations for
posters' inquiries related to decision-making including the changes in disease
state, increased self-awareness, and conflict of information received. Medication
and food were the among the most popular topics discussed as part of their
decision-making inquiries. Additionally, We present insights for automatically
identifying those decision-making inquiries to efficiently support information
needs presented in online health communities.
PMCID: PMC5977569
PMID: 29854261 [Indexed for MEDLINE]
Drug burden index to define the burden of medicines in older adults with
intellectual disabilities: An observational cross-sectional study.
O'Connell J(1)(2), Burke É(2), Mulryan N(2), O'Dwyer C(2), Donegan C(1)(2),
McCallion P(3), McCarron M(4), Henman MC(1), O'Dwyer M(1).
Author information:
(1)School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin,
Ireland.
(2)IDS-TILDA, School of Nursing and Midwifery, Trinity College, Dublin, Ireland.
(3)College of Public Health, Temple University, Philadelphia, USA.
(4)Dean of Health Sciences, Trinity College, Dublin, Ireland.
DOI: 10.1111/bcp.13479
PMCID: PMC5809360
PMID: 29193284 [Indexed for MEDLINE]
Author information:
(1)Department of Epidemiology and Health Statistics, School of Public Health, Sun
Yat-sen University, Guangzhou, Guangdong, China, linaihua@mail.sysu.edu.cn.
(2)Department of Chronic Disease Management, Dadong Community Healthcare Center,
Guangzhou, Guangdong, China.
1512. BMC Health Serv Res. 2018 Mar 1;18(1):149. doi: 10.1186/s12913-018-2950-z.
Delays in seeking and receiving health care services for pneumonia in children
under five in the Peruvian Amazon: a mixed-methods study on caregivers'
perceptions.
Author information:
(1)Office of Global Health, Tulane University School of Public Health and
Tropical Medicine, 1140 Canal Street, Suite 2210, New Orleans, LA, 70112, USA.
Monica.pajuelo.t@upch.pe.
(2)Department of Cellular and Molecular Science. School of Science and
Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru.
Monica.pajuelo.t@upch.pe.
(3)Office of Global Health, Tulane University School of Public Health and
Tropical Medicine, 1140 Canal Street, Suite 2210, New Orleans, LA, 70112, USA.
(4)Department of Cellular and Molecular Science. School of Science and
Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru.
(5)Hospital Regional de Loreto, Iquitos, Peru.
(6)Universidad Nacional de la Amazonia Peruana, Iquitos, Peru.
(7)Department of International Health, Johns Hopkins Bloomberg School of Public
Health, Baltimore, MD, USA.
(8)Department of Global Community Health & Behavioral Sciences, Tulane University
School of Public Health and Tropical Medicine, New Orleans, LA, USA.
DOI: 10.1186/s12913-018-2950-z
PMCID: PMC5831863
PMID: 29490643 [Indexed for MEDLINE]
Kawakami A(1), Tanaka M(2), Naganuma M(3), Maeda S(4), Kunisaki R(5),
Yamamoto-Mitani N(6).
Author information:
(1)Inflammatory Bowel Disease Center, Yokohama City University Medical Center,
Minami-ku, Yokohama, Japan; Department of Gerontological Home Care and Long-term
Care Nursing, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo,
Japan.
(2)Ramathibodi School of Nursing, Faculty of Medicine Ramathibodi Hospital,
Mahidol University, Ratchathewi, Bangkok, Thailand.
(3)Division of Gastroenterology and Hepatology, Keio University, Shinjuku-ku,
Tokyo, Japan.
(4)Department of Gastroenterology, Yokohama City University Graduate School of
Medicine, Kanazawa-ku, Yokohama, Japan.
(5)Inflammatory Bowel Disease Center, Yokohama City University Medical Center,
Minami-ku, Yokohama, Japan.
(6)Department of Gerontological Home Care and Long-term Care Nursing, Graduate
School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
DOI: 10.2147/PPA.S117841
PMCID: PMC5293502
PMID: 28203059
Lynagh MC(1), Clinton-McHarg T(2), Hall A(1), Sanson-Fisher R(1), Stevenson W(3),
Tiley C(1), Bisquera A(4).
Author information:
(1)School of Medicine and Public Health, Faculty of Health and Medicine,
University of Newcastle, Level 4, West, HMRI Building, Callaghan, NSW 2308
Australia.
(2)School of Medicine and Public Health, Faculty of Health and Medicine, The
University of Newcastle, 1127 Booth Building, Wallsend Campus, NSW 2308
Australia.
(3)Department of Haematology Royal North Shore Hospital Pathology North, The
University of Sydney, Sydney, NSW 2006 Australia.
(4)The Clinical Research Design Information Technology and Statistical Support
Unit (CReDITSS), The University of Newcastle, HMRI Building, Callaghan, Sydney,
NSW 2308 Australia.
The influence of cultural and religious orientations on social support and its
potential impact on medication adherence.
Hatah E(1), Lim KP(2), Ali AM(1), Mohamed Shah N(1), Islahudin F(1).
Author information:
(1)Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul
Aziz, Jalan Pahang, Kuala Lumpur, Malaysia.
(2)Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul
Aziz, Jalan Pahang, Kuala Lumpur, Malaysia ; Pharmacy Department, Kuala Lumpur
General Hospital, Jalan Pahang, Kuala Lumpur, Malaysia.
DOI: 10.2147/PPA.S79477
PMCID: PMC4423506
PMID: 25960641
Author information:
(1)Department of Occupational Therapy, School of Allied Health Technologies,
Polytechnic Institute of Porto, Vila Nova de Gaia Portugal ; The Research and
Education Unit on Ageing, Institute of Biomedical Sciences Abel Salazar,
University of Porto, Porto Portugal.
(2)The Research and Education Unit on Ageing, Institute of Biomedical Sciences
Abel Salazar, University of Porto, Porto Portugal.
(3)Faculty of Health, Sports and Social Work, Inholland University of Applied
Sciences, Amsterdam Netherlands ; Zonnehuisgroep Amstelland, Amstelveen
Netherlands.
(4)Center for Health Technology and Services Research (CINTESIS), Faculty of
Medicine, University of Porto, Porto Portugal.
This study aims to analyze which determinants predict frailty in general and each
frailty domain (physical, psychological, and social), considering the integral
conceptual model of frailty, and particularly to examine the contribution of
medication in this prediction. A cross-sectional study was designed using a
non-probabilistic sample of 252 community-dwelling elderly from three Portuguese
cities. Frailty and determinants of frailty were assessed with the Tilburg
Frailty Indicator. The amount and type of different daily-consumed medication
were also examined. Hierarchical regression analysis were conducted. The mean age
of the participants was 79.2 years (±7.3), and most of them were women (75.8%),
widowed (55.6%) and with a low educational level (0-4 years: 63.9%). In this
study, determinants explained 46% of the variance of total frailty, and 39.8,
25.3, and 27.7% of physical, psychological, and social frailty respectively. Age,
gender, income, death of a loved one in the past year, lifestyle, satisfaction
with living environment and self-reported comorbidity predicted total frailty,
while each frailty domain was associated with a different set of determinants.
The number of daily-consumed drugs was independently associated with physical
frailty, and the consumption of medication for the cardiovascular system and for
the blood and blood-forming organs explained part of the variance of total and
physical frailty. The adverse effects of polymedication and its direct link with
the level of comorbidities could explain the independent contribution of the
amount of prescribed drugs to frailty prediction. On the other hand, findings in
regard to medication type provide further evidence of the association of frailty
with cardiovascular risk. In the present study, a significant part of frailty was
predicted, and the different contributions of each determinant to frailty domains
highlight the relevance of the integral model of frailty. The added value of a
simple assessment of medication was considerable, and it should be taken into
account for effective identification of frailty.
DOI: 10.3389/fnagi.2015.00056
PMCID: PMC4404866
PMID: 25954195
1517. Int J Chron Obstruct Pulmon Dis. 2016 Aug 3;11:1811-22. doi:
10.2147/COPD.S105408. eCollection 2016.
Poureslami I(1), Kwan S(2), Lam S(3), Khan NA(4), FitzGerald JM(5).
Author information:
(1)Respiratory Division, Department of Medicine, Faculty of Medicine, University
of British Columbia, Vancouver, Canada; Department of Graduate Studies, Centre
for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research
Institute, Vancouver, Canada.
(2)Respiratory Department, Burnaby Hospital, University of British Columbia,
Burnaby, Canada.
(3)Respiratory Division, University of British Columbia, Vancouver, Canada;
Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, Canada.
(4)Department of Internal Medicine, Faculty of Medicine, University of British
Columbia, Vancouver, Canada; Department of Internal Medicine, Providence Health
Care Authority, Vancouver, Canada.
(5)VGH Divisions of Respiratory Medicine, University of British Columbia,
Vancouver, Canada; Respiratory Medicine, Vancouver Coastal Health Authority,
Vancouver Coastal Health Research Institute, Institute for Heart and Lung Health,
The Lung Centre, Gordon and Leslie Diamond Health Care Centre, Vancouver, Canada.
DOI: 10.2147/COPD.S105408
PMCID: PMC4976815
PMID: 27536093 [Indexed for MEDLINE]
Author information:
(1)Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy,
University of Gothenburg, 413 45, Gothenburg, Sweden. anna.eriksson@pharm.gu.se.
(2)Department of Clinical Pharmacology, Sahlgrenska University Hospital,
Gothenburg, Sweden. anna.eriksson@pharm.gu.se.
(3)Department of Clinical Pharmacology, Sahlgrenska University Hospital,
Gothenburg, Sweden.
(4)Department of Pharmacology, Sahlgrenska Academy, University of Gothenburg,
Gothenburg, Sweden.
DOI: 10.1007/s00228-018-2508-3
PMCID: PMC6132548
PMID: 29955909 [Indexed for MEDLINE]
Reiger S(1)(2)(3), Harris JR(4), Chan KC(5), Oqueli HL(6), Kohn M(4).
Author information:
(1)Department of Medicine, University of Washington School of Medicine, Seattle,
WA, USA.
(2)Department of Epidemiology, University of Washington School of Public Health,
Seattle, WA, USA.
(3)Salud Juntos, Seattle, WA, USA; sreiger@partners.org.
(4)Health Promotion Research Center, Department of Health Services, School of
Public Health, University of Washington, Seattle, WA, USA.
(5)Department of Biostatistics, School of Public Health, University of
Washington, Seattle, WA, USA.
(6)Departmento de Yoro, Morazán, Hector Lopez Oqueli, Secretaría de Salud, Yoro,
Honduras.
DOI: 10.3402/gha.v8.28041
PMCID: PMC4567586
PMID: 26362420 [Indexed for MEDLINE]
Vranian SC Jr(1), Covert KL(2), Mardis CR(3), McGillicuddy JW(4), Chavin KD(5),
Dubay D(4), Taber DJ(6).
Author information:
(1)Division of Transplant Surgery, Medical University of South Carolina,
Charleston, South Carolina. Electronic address: vranian@musc.edu.
(2)College of Pharmacy, Bill Gatton College of Pharmacy, Johnson City, Tennessee.
(3)Transplant Service Line, Medical University of South Carolina, Charleston,
South Carolina.
(4)Division of Transplant Surgery, Medical University of South Carolina,
Charleston, South Carolina.
(5)Department of Surgery, School of Medicine, Case Western Reserve University,
Cleveland, Ohio.
(6)Division of Transplant Surgery, Medical University of South Carolina,
Charleston, South Carolina; Department of Pharmacy Services, Ralph H. Johnson
VAMC, Charleston, South Carolina.
BACKGROUND: There are only a limited number of studies that have sought to
identify patients at high risk for medication errors and subsequent adverse
clinical outcomes. This study sought to identify risk factors for increased
health care resource utilization in kidney transplant recipients based on
drug-related problems and self-administered surveys.
METHODS: In this prospective observational study, adult kidney transplant
recipients seen in the transplant clinic between September and November 2015 were
surveyed for self-reported demographics, medication adherence, and health
status/outlook. Subsequently, patients were assessed for associations between
survey results, pharmacist-derived drug-related problems, and health resource
utilization over a minimum 6-mo follow-up period. Based on univariate
associations, two risk cohorts were identified and compared for health care
utilization using multivariable Poisson regression.
RESULTS: A total of 237 patients were included, with a mean follow-up of 8 mo.
From the patient survey data, Medicaid insured or self-rated poor health status
were identified as a significant risk cohort. From pharmacist assessments, those
who received incorrect medication or lacked appropriate follow-up medication
monitoring were identified as a significant risk cohort (pharmacy errors). The
Medicaid insured or self-rated poor health status cohort experienced 43% more
total health care encounters (incident rate ratios [IRR] 1.43, 1.01-2.02) and 35%
more transplant clinic visits (IRR 1.35, 1.03-1.77). The pharmacy errors cohort
experienced 4.2 times the rate of total health care encounters (IRR 4.17,
1.55-11.2), 4.1 times the rate of hospital readmissions (IRR 4.09, 1.58-10.6),
and 2.3 times the rate of transplant clinic visits (IRR 2.31, 1.04-5.11).
CONCLUSIONS: Medicaid insurance, self-rated poor health status, and errors in the
medication regimen or monitoring were significant risk factors for increased
health care utilization in kidney transplant recipients. Further research is
warranted to validate these potential risk factors, determine the long-term
impact on graft/patient survival, and assess the mutability of these risks
through prospective identification and intervention.
DOI: 10.1016/j.jss.2017.09.037
PMCID: PMC5742052
PMID: 29100587 [Indexed for MEDLINE]
Quinn CC(1), Butler EC(2), Swasey KK(1), Shardell MD(3), Terrin MD(1), Barr
EA(1), Gruber-Baldini AL(1).
Author information:
(1)Department of Epidemiology and Public Health, University of Maryland School of
Medicine, Baltimore, MD, United States.
(2)Department of Emergency Medicine, Wellspan York Hospital, York, PA, United
States.
(3)National Institute on Aging, Baltimore, MD, United States.
BACKGROUND: Successful treatment of diabetes includes patient self-management
behaviors to prevent or delay complications and comorbid diseases. On the basis
of findings from large clinical trials and professional guidelines, diabetes
education programs and health providers prescribe daily regimens of glucose
monitoring, healthy eating, stress management, medication adherence, and physical
activity. Consistent, long-term commitment to regimens is challenging. Mobile
health is increasingly being used to assist patients with lifestyle changes and
self-management behaviors between provider visits. The effectiveness of mobile
health to improve diabetes outcomes depends on patient engagement with a
technology, content, or interactions with providers.
OBJECTIVES: In the current analysis, we aimed to identify patient engagement
themes in diabetes messaging with diabetes providers and determine if differences
in engagement in the Mobile Diabetes Intervention Study (MDIS) influenced changes
in glycated hemoglobin A1c (HbA1c) over a 1-year treatment period (1.9% absolute
decrease in the parent study).
METHODS: In the primary MDIS study, 163 patients were enrolled into 1 of 3 mobile
intervention groups or a usual care control group based on their physician
cluster randomization assignment. The control group received care from their
physicians as usual. Participants in each intervention group had access to a
patient portal where they could record monitoring values for blood glucose, blood
pressure, medication changes, or other self-management information while also
assigned to varying levels of physician access to patient data. Intervention
participants could choose to send and receive messages to assigned certified
diabetes educators with questions or updates through the secure Web portal. For
this secondary analysis, patient engagement was measured using qualitative
methods to identify self-care themes in 4109 patient messages. Mixed methods were
used to determine the impact of patient engagement on change in HbA1c over 1
year.
RESULTS: Self-care behavior themes that received the highest engagement for
participants were glucose monitoring (75/107, 70.1%), medication management
(71/107, 66.4%), and reducing risks (71/107, 66.4%). The average number of
messages sent per patient were highest for glucose monitoring (9.2, SD 14.0) and
healthy eating (6.9, SD 13.2). Compared to sending no messages, sending any
messages about glucose monitoring (P=.03) or medication (P=.01) led to a decrease
in HbA1c of 0.62 and 0.72 percentage points, respectively. Sending any messages
about healthy eating, glucose monitoring, or medication combined led to a
decrease in HbA1c of 0.54 percentage points compared to not sending messages in
these themes (P=.045).
CONCLUSIONS: The findings from this study help validate the efficacy of the
mobile diabetes intervention. The next step is to determine differences between
patients who engage in mobile interventions and those who do not engage and
identify methods to enhance patient engagement.
TRIAL REGISTRATION: ClinicalTrials.gov: NCT01107015;
https://clinicaltrials.gov/ct2/show/NCT01107015 (Archived by WebCite at
http://www.webcitation.org/6wh4ekP4R).
DOI: 10.2196/mhealth.9265
PMCID: PMC5816260
PMID: 29396389
Burke HM(1), Chen M(2), Buluzi M(3), Fuchs R(2), Wevill S(2), Venkatasubramanian
L(2), Dal Santo L(2), Ngwira B(3).
Author information:
(1)FHI 360, Durham, NC, USA. Electronic address: hburke@fhi360.org.
(2)FHI 360, Durham, NC, USA.
(3)College of Medicine, University of Malawi, Blantyre, Malawi.
Comment in
Lancet Glob Health. 2018 May;6(5):e481-e482.
Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access
article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights
reserved.
DOI: 10.1016/S2214-109X(18)30061-5
PMID: 29526707 [Indexed for MEDLINE]
Debono D(1)(2), Taylor N(3), Lipworth W(4), Greenfield D(3)(5), Travaglia J(6),
Black D(7), Braithwaite J(3).
Author information:
(1)Centre for Healthcare Resilience and Implementation Science, Australian
Institute of Health Innovation, Macquarie University, Sydney, NSW, Australia.
deborah.debono@uts.edu.au.
(2)Faculty of Health, University of Technology, Sydney, NSW, Australia.
deborah.debono@uts.edu.au.
(3)Centre for Healthcare Resilience and Implementation Science, Australian
Institute of Health Innovation, Macquarie University, Sydney, NSW, Australia.
(4)Centre for Values, Ethics and Law in Medicine, University of Sydney, Sydney,
NSW, Australia.
(5)Australian Institute of Health Services Management, University of Tasmania,
Sydney, Australia.
(6)Faculty of Health, University of Technology, Sydney, NSW, Australia.
(7)Faculty of Health Sciences, University of Sydney, Sydney, NSW, Australia.
BACKGROUND: Medication errors harm hospitalised patients and increase health care
costs. Electronic Medication Management Systems (EMMS) have been shown to reduce
medication errors. However, nurses do not always use EMMS as intended, largely
because implementation of such patient safety strategies requires clinicians to
change their existing practices, routines and behaviour. This study uses the
Theoretical Domains Framework (TDF) to identify barriers and targeted
interventions to enhance nurses' appropriate use of EMMS in two Australian
hospitals.
METHODS: This qualitative study draws on in-depth interviews with 19 acute care
nurses who used EMMS. A convenience sampling approach was used. Nurses working on
the study units (N = 6) in two hospitals were invited to participate if available
during the data collection period. Interviews inductively explored nurses'
experiences of using EMMS (step 1). Data were analysed using the TDF to identify
theory-derived barriers to nurses' appropriate use of EMMS (step 2). Relevant
behaviour change techniques (BCTs) were identified to overcome key barriers to
using EMMS (step 3) followed by the identification of potential
literature-informed targeted intervention strategies to operationalise the
identified BCTs (step 4).
RESULTS: Barriers to nurses' use of EMMS in acute care were represented by nine
domains of the TDF. Two closely linked domains emerged as major barriers to EMMS
use: Environmental Context and Resources (availability and properties of
computers on wheels (COWs); technology characteristics; specific contexts;
competing demands and time pressure) and Social/Professional Role and Identity
(conflict between using EMMS appropriately and executing behaviours critical to
nurses' professional role and identity). The study identified three potential
BCTs to address the Environmental Context and Resources domain barrier: adding
objects to the environment; restructuring the physical environment; and prompts
and cues. Seven BCTs to address Social/Professional Role and Identity were
identified: social process of encouragement; pressure or support; information
about others' approval; incompatible beliefs; identification of self as role
model; framing/reframing; social comparison; and demonstration of behaviour. It
proposes several targeted interventions to deliver these BCTs.
CONCLUSIONS: The TDF provides a useful approach to identify barriers to nurses'
prescribed use of EMMS, and can inform the design of targeted theory-based
interventions to improve EMMS implementation.
DOI: 10.1186/s13012-017-0572-1
PMCID: PMC5368903
PMID: 28347319 [Indexed for MEDLINE]
Author information:
(1)The University of Texas, Austin School of Nursing, 1710 Red River, Austin, TX
78701 USA.
BACKGROUND: People with diabetes have almost twice the risk of developing
cognitive impairment or dementia as do those without diabetes, and about half of
older adults with diabetes will become functionally disabled or cognitively
impaired. But diabetes requires complex self-management: patients must learn
about the implications of their disease; manage their diets, physical activity,
and medication; and monitor their blood glucose. Difficulties with cognition can
hinder these activities.
METHODS: The purpose of this study was to explore perceptions of cognitive
ability in a multiethnic sample of persons with type 2 diabetes (T2DM). One
hundred twenty participants completed surveys assessing perceived memory,
executive function, diabetes self-management, and quality of life. Scores on the
surveys were examined along with hemoglobin A1C levels and demographics.
RESULTS: Scores for executive function were positively associated with
self-reports of dietary adherence and blood glucose monitoring. Perceived memory
ability was a significant predictor of quality of life, and executive function
was a significant predictor of A1C.
CONCLUSIONS: Patients' perceptions of their cognitive difficulties may assist
health care providers in detection of patients' deficiencies in performing
diabetes self-management tasks. The relationships between cognitive difficulties
and self-management found in this descriptive study suggest that research on the
processes leading to cognitive changes in T2DM is needed, as are studies on how
those processes affect diabetes self-management.
DOI: 10.1186/s40200-017-0289-3
PMCID: PMC5312423
PMID: 28239597
1525. Int J Environ Res Public Health. 2019 Jan 11;16(2). pii: E196. doi:
10.3390/ijerph16020196.
Author information:
(1)School of Social Sciences, Hellenic Open University, 26335 Patra, Greece.
litsachi@hotmail.com.
(2)School of Social Sciences, Hellenic Open University, 26335 Patra, Greece.
ecalexop@med.uoa.gr.
(3)Occupational Health Department, Metropolitan General Hospital, 15562 Athens,
Greece. ecalexop@med.uoa.gr.
DOI: 10.3390/ijerph16020196
PMCID: PMC6351941
PMID: 30641978 [Indexed for MEDLINE]
Gathright EC(1), Dolansky MA(2), Gunstad J(1), Redle JD(3), Josephson RA(4),
Moore SM(2), Hughes JW(1).
Author information:
(1)Department of Psychological Sciences, Kent State University.
(2)Frances Payne Bolton School of Nursing, Case Western Reserve University.
(3)Cardiovascular Institute, Summa Health System, Akron City Hospital.
(4)School of Medicine, Case Western Reserve University.
OBJECTIVE: Heart failure affects more than 5 million U.S. adults, and
approximately 20% of individuals with heart failure experience depressive
symptoms. Depression is detrimental to prognosis in heart failure, conferring
approximately a 2-fold increase in mortality risk. Medication nonadherence may
help explain this relationship because depressed patients are less likely to
adhere to the medication regimen.
METHOD: Depression, electronically monitored medication adherence, and mortality
were measured in a sample of 308 patients with heart failure participating in a
study of self-management behavior. Cardiovascular and all-cause mortality data
were obtained from the Centers for Disease Control and Prevention's National
Death Index (median 2.9-year follow-up). Cox proportional hazards regression was
used to assess the relationship between depression and mortality, with and
without adjustment for age, gender, disease severity, and medication
nonadherence.
RESULTS: In adjusted analyses, depression was associated with an increased
all-cause mortality risk (hazard ratio 1.87; 95% confidence interval 1.04-3.37).
Depression was not related to cardiovascular mortality, potentially because of a
low number of cardiac-related deaths. When medication nonadherence was added to
the model, nonadherence (hazard ratio 1.01; 95% confidence interval 1.004-1.02),
but not depression, predicted all-cause mortality risk.
CONCLUSIONS: Depressive symptoms confer increased all-cause mortality risk in
heart failure, and medication nonadherence contributes to this relationship.
Depression and nonadherence represent potentially modifiable risk factors for
poor prognosis. Future research is needed to understand whether interventions
that concomitantly target these factors can improve outcomes. (PsycINFO Database
Record
DOI: 10.1037/hea0000529
PMCID: PMC5573609
PMID: 28726471 [Indexed for MEDLINE]
1527. AMIA Annu Symp Proc. 2014 Nov 14;2014:1738-47. eCollection 2014.
Author information:
(1)Department of Biomedical Informatics, Columbia University, New York City, NY.
(2)Intermountain Healthcare, Salt Lake City, UT.
Electronic health records (EHRs) have been used as a valuable data source for
phenotyping. However, this method suffers from inherent data quality issues like
data missingness. As patient self-reported health data are increasingly
available, it is useful to know how the two data sources compare with each other
for phenotyping. This study addresses this research question. We used
self-reported diabetes status for 2,249 patients treated at Columbia University
Medical Center and the well-known eMERGE EHR phenotyping algorithm for Type 2
diabetes mellitus (DM2) to conduct the experiment. The eMERGE algorithm achieved
high specificity (.97) but low sensitivity (.32) among this patient cohort. About
87% of the patients with self-reported diabetes had at least one ICD-9 code, one
medication, or one lab result supporting a DM2 diagnosis, implying the remaining
13% may have missing or incorrect self-reports. We discuss the tradeoffs in both
data sources and in combining them for phenotyping.
PMCID: PMC4419899
PMID: 25954446 [Indexed for MEDLINE]
Wilks C(1), Krisle E(1), Westrich K(2), Lunner K(1), Muhlestein D(1), Dubois
R(2).
Author information:
(1)1 Leavitt Partners, Salt Lake City, Utah.
(2)2 National Pharmaceutical Council, Washington, DC.
DOI: 10.18553/jmcp.2017.23.10.1054
PMID: 28944730 [Indexed for MEDLINE]
Haramiova Z(1), Stasko M(2), Hulin M(3), Tesar T(2), Kuzelova M(4), Morisky
DM(5).
Author information:
(1)Department of Organization and Management of Pharmacy, Faculty of Pharmacy,
Comenius University in Bratislava, Kalinciakova 8, 832 32, Bratislava, Slovak
Republic. haramiova@fpharm.uniba.sk.
(2)Department of Organization and Management of Pharmacy, Faculty of Pharmacy,
Comenius University in Bratislava, Kalinciakova 8, 832 32, Bratislava, Slovak
Republic.
(3)Research Institute for Child Psychology and Pathopsychology, Cyprichova 42,
831 05, Bratislava, Slovak Republic.
(4)Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius
University in Bratislava, Odbojarov 10, 832 32, Bratislava, Slovak Republic.
(5)Department of Community Health Sciences, UCLA Fielding School of Public
Health, 650 Charles E. Young Drive South, 46-071 CHS, Los Angeles, CA,
90095-1772, USA.
DOI: 10.1186/s13063-017-2063-8
PMCID: PMC5516377
PMID: 28720121 [Indexed for MEDLINE]
How Does Stigma Affect People Living with HIV? The Mediating Roles of
Internalized and Anticipated HIV Stigma in the Effects of Perceived Community
Stigma on Health and Psychosocial Outcomes.
Turan B(1), Budhwani H(2), Fazeli PL(3), Browning WR(4), Raper JL(5), Mugavero
MJ(5), Turan JM(2).
Author information:
(1)The Department of Psychology, University of Alabama at Birmingham, 415
Campbell Hall, Birmingham, AL, 35294-1170, USA. bturanb@uab.edu.
(2)Department of Health Care Organization and Policy, School of Public Health,
University of Alabama at Birmingham, Birmingham, AL, USA.
(3)Department of Family, Community, and Health Systems, School of Nursing, 1720
2nd Avenue South, Birmingham, AL, 35294-1210, USA.
(4)The Department of Psychology, University of Alabama at Birmingham, 415
Campbell Hall, Birmingham, AL, 35294-1170, USA.
(5)The Department of Medicine, University of Alabama at Birmingham, Birmingham,
AL, USA.
DOI: 10.1007/s10461-016-1451-5
PMCID: PMC5143223
PMID: 27272742 [Indexed for MEDLINE]
Park MS(1), Patel MM(1), Sarezky D(2), Rojas C(1), Choo C(3), Choi M(4), Liu
D(5), Rademaker AW(5), Tanna AP(1).
Author information:
(1)Department of Ophthalmology, Northwestern University Feinberg School of
Medicine, Chicago, IL, United States of America.
(2)Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United
States of America.
(3)Department of Ophthalmology, University of Arizona, Tucson, AZ, United States
of America.
(4)Department of Ophthalmology, Mayo Clinic, Rochester, MN, United States of
America.
(5)Department of Preventive Medicine, Northwestern University Feinberg School of
Medicine, Chicago, IL, United States of America.
DOI: 10.1371/journal.pone.0145764
PMCID: PMC4711577
PMID: 26730605 [Indexed for MEDLINE]
Blom K(1), Jernelöv S(2), Rück C(1), Lindefors N(1), Kaldo V(1).
Author information:
(1)Karolinska Institutet, Department of Clinical Neuroscience, Centre for
Psychiatry Research, Stockholm, Sweden.
(2)Karolinska Institutet, Department of Clinical Neuroscience, Section of
Psychology, Stockholm, Sweden.
Mansell H(1), Rosaasen N(2), West-Thielke P(3), Wichart J(4), Daley C(5), Mainra
R(6), Shoker A(6), Liu J(7), Blackburn D(1).
Author information:
(1)College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon,
Saskatchewan, Canada.
(2)Saskatchewan Transplant Program, Saskatchewan Health Authority, Saskatoon,
Saskatchewan, Canada.
(3)Department of Surgery, University of Illinois Hospital and Health Sciences
System, Chicago, Illinois, USA.
(4)Southern Alberta Transplant Program, Alberta Health Services, Calgary,
Alberta, Canada.
(5)Multi-organ Transplant Program of Atlantic Canada, Halifax, Nova Scotia,
Canada.
(6)College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan,
Canada.
(7)College of Arts and Science, University of Saskatchewan, Saskatoon, SK,
Canada.
DOI: 10.1136/bmjopen-2018-025495
PMCID: PMC6429879
PMID: 30872550
Fang J(1), Zhao G(2), Wang G(3), Ayala C(3), Loustalot F(3).
Author information:
(1)Division for Heart Disease and Stroke Prevention, National Center for Chronic
Disease Prevention and Health Promotion, Centers for Disease Control and
Prevention, Atlanta, GA jfang@cdc.gov.
(2)Division of Population Health, National Center for Chronic Disease Prevention
and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA.
(3)Division for Heart Disease and Stroke Prevention, National Center for Chronic
Disease Prevention and Health Promotion, Centers for Disease Control and
Prevention, Atlanta, GA.
Comment in
J Am Heart Assoc. 2016 Dec 21;5(12):.
BACKGROUND: Hypertension is a major risk factor for heart disease and stroke.
Health insurance coverage affects hypertension treatment and control, but limited
information is available for US adults with hypertension who are classified as
underinsured.
METHODS AND RESULTS: Using Behavioral Risk Factor Surveillance System 2013 data,
we identified adults with self-reported hypertension. On the basis of
self-reported health insurance status and health care-related financial burdens,
participants were categorized as uninsured, underinsured, or adequately insured.
Proxies for health care received included whether they reported taking
antihypertensive medications and whether they visited a doctor for a routine
checkup in the past year. We assessed the association between health insurance
status and health care received, adjusting for selected sociodemographic
characteristics. Among 123 257 participants from 38 states and District of
Columbia with self-reported hypertension, 12% were uninsured, 26% were
underinsured, and 62% were adequately insured. In adjusted models using
adequately insured participants as referent, both uninsured (adjusted odds ratio,
0.39; 95% CI, 0.35-0.43) and underinsured (0.83, 0.76-0.89) participants were
less likely to report using antihypertensive medication than those of adequately
insured participants. Similarly, adjusted odds ratio of visiting a doctor for
routine checkup in the past year were 0.25 (0.23-0.28) for those who were
uninsured and 0.78 (0.72-0.84) for those who were underinsured compared to those
with adequate insurance.
CONCLUSIONS: Uninsured and underinsured participants with hypertension were less
likely to report receiving care compared to those with adequate insurance
coverage. Disparities in health care coverage may necessitate targeted
interventions, even among people with health insurance.
© 2016 The Authors. Published on behalf of the American Heart Association, Inc.,
by Wiley Blackwell.
DOI: 10.1161/JAHA.116.004313
PMCID: PMC5210449
PMID: 28003253 [Indexed for MEDLINE]
1535. BMC Health Serv Res. 2019 Jun 24;19(1):420. doi: 10.1186/s12913-019-4260-5.
Author information:
(1)Centre for Behavioural Science and Applied Psychology, Sheffield Hallam
University, Sheffield, UK. J.gao@shu.ac.uk.
(2)Centre for Behavioural Science and Applied Psychology, Sheffield Hallam
University, Sheffield, UK.
(3)School of Health and Related Research (ScHARR), University of Sheffield,
Sheffield, UK.
(4)Sheffield Adult Cystic Fibrosis Centre, Northern General Hospital, Sheffield,
UK.
DOI: 10.1186/s12913-019-4260-5
PMCID: PMC6591841
PMID: 31234848
Diabetes self-care and its associated factors among elderly diabetes in primary
care.
Author information:
(1)Klinik Kesihatan Jalan lanang, Sibu, Sarawak, Malaysia.
(2)Department of Family Medicine, School of Medical Sciences, Universiti Sains
Malaysia, Kubang Kerian, Kerian, Kelantan, Malaysia.
Publisher: ويقدم متخصصو.داء السكري في المقام الول هو داء يمكن التحكم فيه ذاتيا
ولكن المرضى هم المسئولين عن الدارة، والمساندة، والعلج،الرعاية الصحية التعليم
الدعم الذاتي تأثير كبير على الرعاية- يمكن أن يكون لزيادة فعالية.اليومية لحياتهم
وتهدف هذه الدراسة إلى وصف الرعاية الذاتية لداء السكري. خاصة لدى كبار السن،الصحية
١٤٣ ضمت هذه الدراسة المقطعية. وتحديد العوامل المرتبطة به،بين مرضى السكري المسنين
في العيادات الخارجية للمستشفى الجامعي في سينز ماليزيا،من مرضى السكري المسنين.
والرصد، والنشاط البدني،بحيث قيمت أنشطة الرعاية الذاتية متضمنة السيطرة الغذائية
التي، وسلوك اللتزام المتعلق بالمواقف، واللتزام بالدواء،الذاتي للجلوكوز بالدم
كان.تم الحصول عليها باستخدام استبانة مالي للرعاية الذاتية لمرضى السكري المسنين
وكان معظمهم من.( عاما٥.٤±)٦٧.٩ ( النحراف المعياري± ) متوسط أعمار المشاركين
وكان متوسط درجة الرعاية الذاتية.(١.٩±) ٨.٤ ومتوسط الهيموجلوبين السكري،مالي
والعوامل التي لها تأثير موجب على الرعاية الذاتية لداء.(٨.٠±) ٢٦.٥ لداء السكري
ودعم أسري أكبر، ولديه أسرة مقدمة للرعاية، كون المريض ليس من مالي:السكري تشمل،
ووجود العتلل العصبي يؤثر. والمعرفة الجيدة،وامتلك معرفة مقبولة بداء السكري
لدى كبار السن. بينما للعتلل الكلوي تأثير إيجابي،سلبا على الرعاية الذاتية
درجة معتدلة من ممارسة الرعاية الذاتية لداء السكري،٢ المصابون بداء السكري النوع
وتشمل محددات.بناء على استبانة مالي للرعاية الذاتية لمرضى السكري المسنين
ووجود مقدمي، والدعم الجتماعي،الممارسة الجيدة للرعاية الذاتية لداء السكري الدعرق
ومضاعفات الوعية الدموية لداء، والمعرفة بداء السكري،الرعاية أثناء فترات المرض
السكري.
DOI: 10.1016/j.jtumed.2017.03.008
PMCID: PMC6694907
PMID: 31435286
Author information:
(1)Pharmaceutical Care Research Unit, Department of Pharmacy Practice, Faculty of
Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.
(2)Faculty of Pharmacy, The University of Sydney, Camperdown, NSW, Australia.
DOI: 10.2147/PPA.S88071
PMCID: PMC4527368
PMID: 26257514
Author information:
(1)Chitwan Sakriya Women's foundation, Bharatpur, Chitwan, Nepal.
smilewith_sujan@yahoo.com.
(2)Department of Statistics, Birendra Multiple Campus, Bharatpur, Nepal.
(3)Tribhuvan University, Kirtipur, Nepal.
DOI: 10.1186/s12889-019-7051-3
PMCID: PMC6558692
PMID: 31182074 [Indexed for MEDLINE]
1539. Subst Abuse Treat Prev Policy. 2017 Jun 8;12(1):31. doi:
10.1186/s13011-017-0115-4.
Nguyen LH(1), Nguyen HTT(2)(3), Nguyen HLT(4), Tran BX(2)(5), Latkin CA(5).
Author information:
(1)School of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.
(2)Institute for Preventive Medicine and Public Health, Hanoi Medical University,
Hanoi, Vietnam.
(3)Thanh Nhan Hospital, Hanoi, Vietnam.
(4)Institute for Global Health Innovations, Duy Tan University, Da Nang, Vietnam.
lanhuong.hmu@gmail.com.
(5)Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
DOI: 10.1186/s13011-017-0115-4
PMCID: PMC5465686
PMID: 28595642 [Indexed for MEDLINE]
Claes L(1)(2), Turner B(3)(4), Dierckx E(5)(6), Luyckx K(1)(7), Verschueren M(1),
Schoevaerts K(5).
Author information:
(1)Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, BE.
(2)Faculty of Medicine and Health Sciences, University Antwerp, Antwerp, BE.
(3)Department of Psychology, University of Victoria, Victoria, BC, CA.
(4)Department of Psychology, Harvard University, Cambridge, MA, US.
(5)Psychiatric Hospital Alexianen Tienen, Tienen, BE.
(6)Department of Psychology and Educational Sciences, Vrije Universiteit Brussel,
Brussels, BE.
(7)UNIBS, University of the Free State, Bloemfontein, ZA.
DOI: 10.5334/pb.420
PMCID: PMC6194535
PMID: 30479820
The validity of self-reported drug use with urine test: results from the pilot
phase of Azar cohort study.
Ashrafi S(1), Aminisani N(1), Soltani S(2), Sarbakhsh P(1), Shamshirgaran SM(1),
Rashidi MR(2).
Author information:
(1)Epidemiology and Statistics Departement, Tabriz University of Medical
Sciences, Tabriz, Iran.
(2)Department of Medicinal Chemistry, Tabriz University of Medical Sciences,
Tabriz, Iran.
DOI: 10.15171/hpp.2018.30
PMCID: PMC6064750
PMID: 30087846
1542. Implement Sci. 2015 Sep 24;10:132. doi: 10.1186/s13012-015-0322-1.
Sinnott C(1), Mercer SW(2), Payne RA(3), Duerden M(4), Bradley CP(5), Byrne M(6).
Author information:
(1)Department of General Practice, University College Cork, Cork, Ireland.
csinnott@ucc.ie.
(2)General Practice and Primary Care, Institute of Health and Wellbeing,
University of Glasgow, Glasgow, UK. Stewart.Mercer@glasgow.ac.uk.
(3)Cambridge Centre for Health Services Research, Institute of Public Health,
University of Cambridge, Cambridge, UK. rap55@medschl.cam.ac.uk.
(4)Centre for Health Economics and Medicines Evaluation, Bangor University,
Bangor, UK. martin@theduerdens.co.uk.
(5)Department of General Practice, University College Cork, Cork, Ireland.
C.Bradley@ucc.ie.
(6)Health Behaviour Change Research Group, School of Psychology, National
University of Ireland, Galway, Ireland. molly.byrne@nuigalway.ie.
DOI: 10.1186/s13012-015-0322-1
PMCID: PMC4582886
PMID: 26404642 [Indexed for MEDLINE]
Forbes MK(1), Flanagan JC(2), Barrett EL(3), Crome E(4), Baillie AJ(5), Mills
KL(6), Teesson M(7).
Author information:
(1)Centre for Emotional Health and Centre of Research Excellence in Mental Health
and Substance Abuse, Macquarie University, Sydney, NSW 2109, Australia.
Electronic address: miri.forbes@mq.edu.au.
(2)Medical University of South Carolina, 5 Charleston Center Drive, Suite 151,
Charleston, SC 29401, United States. Electronic address: hellmuth@musc.edu.
(3)Centre of Research Excellence in Mental Health and Substance Abuse and
National Drug and Alcohol Research Centre, UNSW, Sydney, NSW 2052, Australia.
Electronic address: e.barrett@unsw.edu.au.
(4)Centre for Emotional Health and Centre of Research Excellence in Mental Health
and Substance Abuse, Macquarie University, Sydney, NSW 2109, Australia.
Electronic address: erica.crome@mq.edu.au.
(5)Centre for Emotional Health and Centre of Research Excellence in Mental Health
and Substance Abuse, Macquarie University, Sydney, NSW 2109, Australia.
Electronic address: andrew.baillie@mq.edu.au.
(6)Centre of Research Excellence in Mental Health and Substance Abuse and
National Drug and Alcohol Research Centre, UNSW, Sydney, NSW 2052, Australia.
Electronic address: k.mills@unsw.edu.au.
(7)Centre of Research Excellence in Mental Health and Substance Abuse and
National Drug and Alcohol Research Centre, UNSW, Sydney, NSW 2052, Australia.
Electronic address: m.teesson@unsw.edu.au.
BACKGROUND: Posttraumatic stress disorder (PTSD) and alcohol use disorders (AUDs)
often co-occur with smoking and tobacco use disorders. Each of these disorders is
known to have negative health consequences and impairment independently, but
little is known about the impact of their co-occurrence. The aim of the present
study is to examine the prevalence, correlates, order of onset, and impact of
co-occurring daily smoking, PTSD, and AUDs.
METHOD: The 2007 Australian National Survey of Mental Health and Wellbeing (2007
NSMHWB) was a nationally representative survey of 8841 Australians. The survey
assessed for 12-month DSM-IV mental disorders; the age respondents first started
smoking daily, experienced a traumatic event, or developed problems with alcohol;
and self-reported mental and physical health and impairment.
RESULTS: There were systematic patterns of co-occurrence between daily smoking,
PTSD, and AUDs. Daily smoking and problems with alcohol use tended to develop
after first trauma exposure, which is broadly consistent with the self-medication
hypothesis. Daily smoking, PTSD, and AUDs were also associated with additive
negative effects on mental and physical health and functioning, after controlling
for demographics.
CONCLUSIONS: Smoking, PTSD, and AUDs commonly co-occur in this nationally
representative sample of Australian men and women, and this comorbidity was
associated with greater severity of mental and physical health problems and
impairment in several areas of functioning. This study highlights the importance
of identifying and eliminating these patterns of co-occurrence, potentially
through integrated interventions.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
DOI: 10.1016/j.drugalcdep.2015.09.007
PMCID: PMC4633362
PMID: 26386825 [Indexed for MEDLINE]
Author information:
(1)Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Selangor,
Malaysia Department of Pharmacy Practice and Development, Malacca State
Pharmaceutical Services Division, Ayer Keroh, Malacca, Malaysia.
(2)Community Health Research Cluster, Faculty of Health Sciences, Universiti
Sultan Zainal Abidin (UniSZA), Kampus Gong Badak, Kuala Nerus, Terengganu,
Malaysia.
(3)Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Selangor,
Malaysia Department of Pharmaceutical & Life Sciences, Communities of Research,
Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://www.bmj.com/company/products-services/rights-and-licensing/
DOI: 10.1136/bmjopen-2015-008889
PMCID: PMC4663412
PMID: 26610761 [Indexed for MEDLINE]
Relative toxicity of mood stabilisers and antipsychotics: case fatality and fatal
toxicity associated with self-poisoning.
Ferrey AE(1)(2), Geulayov G(3), Casey D(3), Wells C(4), Fuller A(5), Bankhead
C(5), Ness J(6), Clements C(7), Gunnell D(8), Kapur N(7), Hawton K(3).
Author information:
(1)Centre for Suicide Research, Department of Psychiatry, University of Oxford,
Warneford Hospital, Oxford, UK. anne.ferrey@phc.ox.ac.uk.
(2)Nuffield Department of Primary Care Health Sciences, University of Oxford,
Oxford, UK. anne.ferrey@phc.ox.ac.uk.
(3)Centre for Suicide Research, Department of Psychiatry, University of Oxford,
Warneford Hospital, Oxford, UK.
(4)Office for National Statistics, Newport, UK.
(5)Nuffield Department of Primary Care Health Sciences, University of Oxford,
Oxford, UK.
(6)Centre for Self-harm and Suicide Prevention Research, Derbyshire Healthcare
NHS Foundation Trust, Derby, UK.
(7)Centre for Suicide Prevention, University of Manchester, Manchester, UK.
(8)School of Social and Community Medicine, University of Bristol, Bristol, UK.
DOI: 10.1186/s12888-018-1993-3
PMCID: PMC6307121
PMID: 30587176
PMCID: PMC6065490
PMID: 30100689
Author information:
(1)Drs. Girdwichai, Chanprapaph, and Vachiramon are with the Division of
Dermatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University in
Bangkok, Thailand.
Background: Cosmetic treatments have gained popularity worldwide. However, little
is known about the behaviors and attitudes toward cosmetic treatments in men.
Objective: The authors sought to explore the behaviors and attitudes toward
cosmetic treatments in male patients. Patients/Methods: A cross-sectional study
was conducted involving male patients aged 18 to 70 years, who presented for
cosmetic consultation at an outpatient dermatology clinic in a university-based
hospital. Behaviors and attitudes were assessed using a self-response
questionnaire. For comparison, female patients with the same inclusion criteria
were also assessed. Results: A total of 302 male patients completed the
questionnaire. The internet and close family members were the two most important
sources of cosmetic treatment information. Men preferred oral medication compared
to women (p<0.01). Regarding topical medication, men prefer gel formulations,
tube containers, and white-colored packaging. The maximum chosen number of
topical medication is three items. The most important factor in medical provider
selection was the dermatologists' knowledge and expertise. Conclusion: Behaviors
and attitudes toward cosmetic treatment in male patients were different from
those seen in female patients. It is essential to alter the approaches regarding
cosmetic treatments when treating men.
PMCID: PMC5868785
PMID: 29607001
Conflict of interest statement: FUNDING:No funding was provided for this article.
DISCLOSURES:The authors have no conflicts of interest relevant to the content of
this article.
Meadows GN(1)(2)(3), Prodan A(4)(5), Patten S(6), Shawyer F(1), Francis S(1),
Enticott J(1)(7), Rosenberg S(8)(9), Atkinson JA(6)(10)(11)(12), Fossey E(13),
Kakuma R(14).
Author information:
(1)1 Southern Synergy, Department of Psychiatry, School of Clinical Sciences at
Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash
University, Melbourne, VIC, Australia.
(2)2 Adult Mental Health, Monash Health, Melbourne, VIC, Australia.
(3)3 Melbourne School of Population and Global Health, The University of
Melbourne, VIC, Australia.
(4)4 Computing & ICT Organisational Unit, School of Computing, Engineering and
Mathematics, Western Sydney University, Sydney, NSW, Australia.
(5)5 Decision Analytics, Sax Institute, Sydney, NSW, Australia.
(6)6 Department of Community Health Sciences and Psychiatry, University of
Calgary, Calgary, AB, Canada.
(7)7 Department of General Practice, School of Primary and Allied Health Care,
Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne,
VIC, Australia.
(8)8 Brain and Mind Centre, School of Medical Sciences, The University of Sydney,
Sydney, NSW, Australia.
(9)9 Centre for Mental Health Research, Australian National University, Canberra,
ACT, Australia.
(10)10 Menzies Centre for Health Policy, Faculty of Medicine, The University of
Sydney, Sydney, NSW, Australia.
(11)11 Simulation for Policy, The Australian Prevention Partnership Centre,
Sydney, NSW, Australia.
(12)12 Translational Health Research Institute, Western Sydney University,
Sydney, NSW, Australia.
(13)13 Department of Occupational Therapy, School of Primary and Allied Health
Care, Faculty of Medicine, Nursing and Health Sciences, Monash University,
Melbourne, Australia.
(14)14 Faculty of Epidemiology and Population Health, Department of Population
Health, London School of Hygiene & Tropical Medicine, London, UK.
DOI: 10.1177/0004867419857821
PMID: 31238699
1549. Addiction. 2018 Jan;113(1):67-79. doi: 10.1111/add.13922. Epub 2017 Aug 10.
Tompkins DA(1), Huhn AS(1), Johnson PS(2), Smith MT(1), Strain EC(1), Edwards
RR(3), Johnson MW(1).
Author information:
(1)Department of Psychiatry and Behavioral Sciences, Johns Hopkins University
School of Medicine, Baltimore, MD, USA.
(2)Department of Psychology, California State University, Chico, Chico, CA, USA.
(3)Department of Anesthesiology, Perioperative, and Pain Medicine, Harvard
Medical School, Brigham and Women's Hospital, Boston, MA, USA.
BACKGROUND AND AIMS: Probability discounting refers to the effect of outcome
uncertainty on decision making. Using probability discounting, we examined the
degree to which self-identified chronic pain patients (CPP) were likely to try a
novel analgesic medication given increasing addiction risk. We postulated that
propensity for opioid misuse, trait impulsivity and previous opioid experience
would be associated positively with likelihood of risky medication use.
DESIGN: This cross-sectional on-line study determined state/trait associations
with addiction-related medication decisions in CPP.
SETTING: US-based CPP participated via Amazon Mechanical Turk; data were
collected and analyzed in Baltimore, Maryland.
PARTICIPANTS: A total of 263 CPP (70.6% female) participated in the study from
12-13 December 2014.
MEASUREMENTS: CPP responded to the Benefit versus Addiction Risk Questionnaire
(BARQ) assessing likelihood of taking a hypothetical once-daily oral analgesic
medication as a function of two factors: risk of addiction (0-50%) and duration
of expected complete pain relief (3, 30 or 365 days). The primary outcome was the
BARQ, quantified as area under the curve (AUC). Grouping of CPP at high or low
risk for opioid misuse was based on the Screener and Opioid Assessment for
Patients with Pain-Revised (SOAPP-R). Predictors included previous experience
with opioids, as well as various measures of chronic pain and mental health.
FINDINGS: Across hypothetical addiction risk assessed in the BARQ, the likelihood
of taking a novel analgesic medication was elevated significantly in patients
with high (≥18; n = 137) versus low (<18; n = 126) SOAPP-R scores [P < 0.001;
3-day: Cohen's d = 0.66, 95% confidence interval (CI) = 0.63, 0.69; 30-day:
d = 0.74, 95% CI = 0.71, 0.78; 365-day: d = 0.75, 95% CI = 0.72, 0.79].
CONCLUSIONS: In the United States, self-identified chronic pain patients (CPP) at
higher risk for opioid misuse were more likely to report willingness to try a
novel analgesic despite increasing addiction risk than CPP with low risk of
opioid misuse.
DOI: 10.1111/add.13922
PMCID: PMC5725253
PMID: 28645137 [Indexed for MEDLINE]
SMS education for the promotion of diabetes self-management in low & middle
income countries: a pilot randomized controlled trial in Egypt.
Author information:
(1)Peter L. Reichertz Institute for Medical Informatics, Hannover Medical School,
Carl-Neuberg-Str. 1, 30625, Hannover, Germany. haitham.abaza@plri.de.
(2)Peter L. Reichertz Institute for Medical Informatics, Hannover Medical School,
Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
BACKGROUND: Due to the ubiquity of mobile phones in low and middle income
countries, we aimed to examine the feasibility of SMS education among diabetic
patients in Egypt, and assess the impact of educational text messages, compared
to traditional paper-based methods, on glycemic control and self-management
behaviors.
METHODS: We conducted a 12-week randomized controlled trial at Misr University
for Science & Technology hospital in Cairo-Egypt. Known as MUST diabetes
awareness program, patients were included if they had diabetes, owned a mobile
phone, and could read SMS messages or lived with someone that could read for
them. Intervention patients received daily messages and weekly reminders
addressing various diabetes care categories. We expected greater improvement in
their glycemic control compared to controls who only received paper-based
educational material. The primary outcome was the change in HbA1c, measured by
the difference between endpoint and baseline values and by the number of patients
who experienced at least 1% reduction from baseline to endpoint. Key secondary
outcomes included blood glucose levels, body weight, treatment and medication
adherence, self-efficacy, and diabetes knowledge. Data were analyzed using
ANCOVA, chi-square, and t-tests.
RESULTS: Thirty four intervention and 39 control patients completed the study.
Over 12 weeks, 3880 messages were sent. Each intervention patient received 84
educational and 12 reminder messages plus one welcome message. Our primary
outcome did not differ significantly (Δ 0.290; 95% CI -0.402 to 0.983; p = 0.406)
between groups after 3 months, demonstrating a mean drop of -0.69% and -1.05% in
the control and intervention group respectively. However, 16 intervention
patients achieved the targeted 1% drop versus only 6 controls, suggesting clear
association between study group and 1% HbA1c reductions (chi-square = 8.655;
df = 1; p = 0.003). Secondary outcomes seemed in favor of intervention patients
at endpoint, with considerable improvements in treatment and medication
adherence, self-efficacy, and knowledge scores. Participants also indicated full
satisfaction with the program.
CONCLUSIONS: SMS education is a feasible and acceptable method for improving
glycemic control and self-management behaviors among Egyptian diabetics. However,
whether it is more effective than traditional paper-based methods needs further
investigation.
TRIAL REGISTRATION: ClinicalTrials.gov NCT02868320 . Registered 9 August 2016.
Retrospectively registered.
DOI: 10.1186/s12889-017-4973-5
PMCID: PMC5735794
PMID: 29258499 [Indexed for MEDLINE]
Author information:
(1)Institute of Health and Care Sciences, Sahlgrenska Academy, University of
Gothenburg, Gothenburg, Sweden.
(2)Centre for Person-Centred Care (GPCC), Sahlgrenska Academy, University of
Gothenburg, Gothenburg, Sweden.
(3)Department of Applied IT, University of Gothenburg, Gothenburg, Sweden.
DOI: 10.1038/jhh.2015.37
PMCID: PMC4705419
PMID: 25903164 [Indexed for MEDLINE]
Author information:
(1)Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine,
University of Pennsylvania, Philadelphia, PA, USA.
(2)Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA,
USA.
(3)Department of Pediatrics, The Children's Hospital of Philadelphia,
Philadelphia, PA, USA.
(4)Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA,
USA. millerv@email.chop.edu.
(5)Department of Pediatrics, The Children's Hospital of Philadelphia,
Philadelphia, PA, USA. millerv@email.chop.edu.
OBJECTIVE: The current study examined how a comprehensive set of variables from
multiple domains, including at the adolescent and family level, were predictive
of glycemic control in adolescents with type 1 diabetes (T1D).
METHODS: Participants included 100 adolescents with T1D ages 10-16 yrs and their
parents. Participants were enrolled in a longitudinal study about youth
decision-making involvement in chronic illness management of which the baseline
data were available for analysis. Bivariate associations with glycemic control
(HbA1C) were tested. Hierarchical linear regression was implemented to inform the
predictive model.
RESULTS: In bivariate analyses, race, family structure, household income, insulin
regimen, adolescent-reported adherence to diabetes self-management, cognitive
development, adolescent responsibility for T1D management, and parent behavior
during the illness management discussion were associated with HbA1c. In the
multivariate model, the only significant predictors of HbA1c were race and
insulin regimen, accounting for 17% of the variance. Caucasians had better
glycemic control than other racial groups. Participants using pre-mixed insulin
therapy and basal-bolus insulin had worse glycemic control than those on insulin
pumps.
CONCLUSIONS: This study shows that despite associations of adolescent and
family-level variables with glycemic control at the bivariate level, only race
and insulin regimen are predictive of glycemic control in hierarchical
multivariate analyses. This model offers an alternative way to examine the
relationship of demographic and psychosocial factors on glycemic control in
adolescents with T1D.
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
DOI: 10.1111/pedi.12331
PMCID: PMC4840099
PMID: 26486450 [Indexed for MEDLINE]
Parker RA(1)(2)(3)(4), Rabideau DJ(1), Sax PE(3)(5), Tierney C(6), Daar ES(7)(8),
Collier AC(9), Losina E(2)(3)(4)(10)(11)(12), Freedberg KA(2)(3)(4)(11)(13)(14).
Author information:
(1)Biostatistics Center, and.
(2)Medical Practice Evaluation Center, Massachusetts General Hospital.
(3)Harvard Medical School.
(4)Harvard University Center for AIDS Research.
(5)Division of Infectious Diseases, Brigham and Women's Hospital, and.
(6)Center for Biostatistics in AIDS Research in the Department of Biostatistics,
Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
(7)Division of HIV Medicine, Los Angeles Biomedical Research Institute at
Harbor-UCLA Medical Center, Torrance, and.
(8)David Geffen School of Medicine at UCLA, Los Angeles, California.
(9)Division of Allergy and Infectious Diseases, University of Washington,
Seattle; and.
(10)Department of Orthopedic Surgery, Brigham and Women's Hospital.
(11)Department of Epidemiology, Boston University School of Public Health.
(12)Department of Biostatistics, Boston University School of Public Health.
(13)Divisions of General Internal Medicine and Infectious Diseases, Massachusetts
General Hospital, and.
(14)Department of Health Policy and Management, Harvard School of Public Health,
Boston, Massachusetts.
In AIDS Clinical Trials Group A5202, participants who reported missing their
medication within the past month or not providing adherence reports at both 8 and
24 weeks had 5 times the hazard of virological failure compared to more adherent
participants. Adherence interventions should focus on such patients.
© The Author 2017. Published by Oxford University Press for the Infectious
Diseases Society of America.
DOI: 10.1093/cid/cix176
PMCID: PMC5434358
PMID: 28329243 [Indexed for MEDLINE]
Depp CA(1), Moore RC(2), Dev SI(2), Mausbach BT(3), Eyler LT(2), Granholm EL(2).
Author information:
(1)UC San Diego Department of Psychiatry, La Jolla, CA, United States; VA San
Diego, La Jolla, CA, United States. Electronic address: cdepp@ucsd.edu.
(2)UC San Diego Department of Psychiatry, La Jolla, CA, United States; VA San
Diego, La Jolla, CA, United States.
(3)UC San Diego Department of Psychiatry, La Jolla, CA, United States.
DOI: 10.1016/j.jad.2015.12.016
PMCID: PMC4915941
PMID: 26773907 [Indexed for MEDLINE]
iOS Appstore-Based Phone Apps for Diabetes Management: Potential for Use in
Medication Adherence.
Martinez M(1), Park SB(1), Maison I(1), Mody V(1), Soh LS(1), Parihar HS(1).
Author information:
(1)Philadelphia College of Osteopathic Medicine - GA campus, School of Pharmacy,
Suwanee, GA, United States.
BACKGROUND: Currently, various phone apps have been developed to assist patients.
Many of these apps are developed to assist patients in the self-management of
chronic diseases such as diabetes. It is essential to analyze these various apps
to understand the key features that would potentially be instrumental in helping
patients successfully achieve goals in disease self-management.
OBJECTIVE: The objective of this study was to conduct a review of all the
available diabetes-related apps in the iOS App Store to evaluate which diabetic
app is more interactive and offers a wide variety of operations such as
monitoring glucose, water, carbohydrate intake, weight, body mass index (BMI),
medication, blood pressure (BP) levels, reminders or push notifications, food
database, charts, exercise management, email, sync between devices, syncing data
directly to the prescribers, and other miscellaneous functions such as (Twitter
integration, password protection, retina display, barcode scanner, apple watch
functionality, and cloud syncing).
METHODS: Data was gathered using the iOS App Store on an iPad. The search term
"diabetes" resulted in 1209 results. Many of the results obtained were remotely
related to diabetes and focused mainly on diet, exercise, emergency services,
refill reminders, providing general diabetes information, and other
nontherapeutic options. We reviewed each app description and only included apps
that were meant for tracking blood glucose levels. All data were obtained in one
sitting by one person on the same device, as we found that carrying out the
search at different times or on different devices (iPhones) resulted in varying
results. Apps that did not have a feature for tracking glucose levels were
excluded from the study.
RESULTS: The search resulted in 1209 results; 85 apps were retained based on the
inclusion criteria mentioned above. All the apps were reviewed for average
customer ratings, number of reviews, price, and functions. Of all the apps
surveyed, 18 apps with the highest number of user ratings were used for in-depth
analysis. Of these 18 apps, 50% (9/18) also had a medication adherence function.
Our analysis revealed that the Diabetes logbook used by the mySugr app was one of
the best; it differentiated itself by introducing fun as a method of increasing
adherence.
CONCLUSIONS: A large variation was seen in patient ratings of app features. Many
patient reviewers desired simplicity of app functions. Glucose level tracking and
email features potentially helped patients and health care providers manage the
disease more efficiently. However, none of the apps could sync data directly to
the prescribers. Additional features such as graph customization, availability of
data backup, and recording previous entries were also requested by many users.
Thus, the use of apps in disease management and patient and health-care provider
involvement in future app refinement and development should be encouraged.
©Mark Martinez, Su Bin Park, Isaac Maison, Vicky Mody, Lewis Sungkon Soh, Harish
Singh Parihar. Originally published in JMIR Diabetes (http://diabetes.jmir.org),
11.07.2017.
DOI: 10.2196/diabetes.6468
PMCID: PMC6238890
PMID: 30291096
1556. BMC Med Inform Decis Mak. 2017 Jan 9;17(1):5. doi: 10.1186/s12911-016-0397-x.
Bradbury K(1), Morton K(2), Band R(2), May C(3), McManus R(4), Little P(5),
Yardley L(2).
Author information:
(1)Academic unit of psychology, University of Southampton, Southampton, UK.
kjb1e08@soton.ac.uk.
(2)Academic unit of psychology, University of Southampton, Southampton, UK.
(3)Faculty of Health Sciences, University of Southampton, Southampton, UK.
(4)Nuffield Department of Primary Care Health Sciences, University of Oxford,
Oxford, UK.
(5)Primary Care and Population Sciences, Faculty of Medicine, University of
Southampton, Southampton, UK.
BACKGROUND: In order to achieve successful implementation an intervention needs
to be acceptable and feasible to its users and must overcome barriers to
behaviour change. The Person-Based Approach can help intervention developers to
improve their interventions to ensure more successful implementation. This study
provides an example of using the Person-Based Approach to refine a digital
intervention for hypertension (HOME BP).
METHODS: Our Person-Based Approach involved conducting qualitative focus groups
with practice staff to explore their perceptions of HOME BP and to identify any
potential barriers to implementation of the HOME BP procedures. We took an
iterative approach moving between data collection, analysis and modifications to
the HOME BP intervention, followed by further data collection. The data was
analysed using thematic analysis.
RESULTS: Many aspects of HOME BP appeared to be acceptable, persuasive and
feasible to implement. Practitioners perceived benefits in using HOME BP,
including that it could empower patients to self-manage their health, potentially
overcome clinical inertia around prescribing medication and save both the patient
and practitioner time. However, practitioners also had some concerns. Some
practitioners were concerned about the accuracy of patients' home blood pressure
readings, or the potential for home monitoring to cause patients anxiety and
therefore increase consultations. Some GPs lacked confidence in choosing multiple
medication changes, or had concerns about unanticipated drug interactions. A few
nurses were concerned that the model of patient support they were asked to
provide was not consistent with their perceived role. Modifications were made to
the intervention based on this feedback, which appeared to help overcome
practitioners' concerns and improve the acceptability and feasibility of the
intervention.
CONCLUSIONS: This paper provides a detailed example of using the Person-Based
Approach to refine HOME BP, demonstrating how we improved the acceptability and
feasibility of HOME BP based on feedback from practice staff. This demonstration
may be useful to others developing digital interventions.
DOI: 10.1186/s12911-016-0397-x
PMCID: PMC5223423
PMID: 28069041 [Indexed for MEDLINE]
Lyles CR(1)(2), Seligman HK(3), Parker MM(2), Moffet HH(2), Adler N(4),
Schillinger D(3)(2), Piette JD(5), Karter AJ(2).
Author information:
(1)University of California San Francisco, 1001 Potrero Ave, San Francisco, CA.
(2)Kaiser Permanente Northern California Division of Research, Oakland, CA.
(3)Division of General Internal Medicine at SFGH, UCSF Center for Vulnerable
Populations, San Francisco, CA.
(4)UCSF Departments of Psychiatry and Pediatrics, San Francisco, CA.
(5)Schools of Public Health and Medicine, VA Ann Arbor Center for Clinical
Management Research, University of Michigan, Ann Arbor, MI.
DOI: 10.1111/1475-6773.12346
PMCID: PMC4799896
PMID: 26256117 [Indexed for MEDLINE]
Siefried KJ(1), Mao L, Cysique LA, Rule J, Giles ML, Smith DE, McMahon J, Read
TR, Ooi C, Tee BK, Bloch M, de Wit J, Carr A; PAART study investigators.
Author information:
(1)aSt Vincent's Centre for Applied Medical Research, St Vincent's Hospital,
SydneybCentre for Social Research in HealthcNeuroscience Research Australia,
University of New South Wales, SydneydNational Association of People with HIV
Australia, NewtowneSchool of Public Health and Community Medicine, University of
New South Wales, Sydney, New South WalesfDepartment of Infectious Diseases,
Alfred Hospital and Monash UniversitygDepartment of Infectious Diseases, The
Royal Women's HospitalhMonash Infectious Diseases, Monash Health, Melbourne,
VictoriaiAlbion Centre, South Eastern Sydney Local Hospital Network, Sydney, New
South WalesjCentre for Population Health, Burnet InstitutekMelbourne Sexual
Health Centre, Alfred HealthlCentral Clinical School, Faculty of Medicine,
Nursing and Health Sciences, Monash University, Melbourne, VictoriamWestern
Sydney Sexual Health Centre, University of Sydney, ParramattanWestmead Clinical
School, Sydney Medical School, University of Sydney, Westmead, New South
WalesoCentre Clinic, St Kilda, Melbourne, VictoriapHoldsworth House Medical
PracticeqThe Kirby Institute, University of New South Wales, Sydney, New South
Wales, AustraliarDepartment of Interdisciplinary Social Science, Utrecht
University, Utrecht, The Netherlands.
DOI: 10.1097/QAD.0000000000001685
PMCID: PMC5732638
PMID: 29135584 [Indexed for MEDLINE]
Author information:
(1)Group Health Research Institute, Seattle, WA, United States.
McClure.J@ghc.org.
BACKGROUND: Mobile health (mHealth) interventions hold great promise for helping
smokers quit since these programs can have wide reach and facilitate access to
comprehensive, interactive, and adaptive treatment content. However, the
feasibility, acceptability, and effectiveness of these programs remain largely
untested.
OBJECTIVE: To assess feasibility and acceptability of the My Mobile Advice
Program (MyMAP) smoking cessation program and estimate its effects on smoking
cessation and medication adherence to inform future research planning.
METHODS: Sixty-six smokers ready to quit were recruited from a large regional
health care system and randomized to one of two mHealth programs: (1) standard
self-help including psychoeducational materials and guidance how to quit smoking
or (2) an adaptive and interactive program consisting of the same standard
mHealth self-help content as controls received plus a) real-time, adaptively
tailored advice for managing nicotine withdrawal symptoms and medication
side-effects and b) asynchronous secure messaging with a cessation counselor.
Participants in both arms were also prescribed a 12-week course of varenicline.
Follow-up assessments were conducted at 2 weeks post-target quit date (TQD), 3
months post-TQD, and 5 months post-TQD. Indices of program feasibility and
acceptability included acceptability ratings, utilization metrics including use
of each MyMAP program component (self-help content, secure messaging, and
adaptively tailored advice), and open-ended feedback from participants. Smoking
abstinence and medication adherence were also assessed to estimate effects on
these treatment outcomes.
RESULTS: Utilization data indicated the MyMAP program was actively used, with
higher mean program log-ins by experimental than control participants (10.6 vs
2.7, P<.001). The majority of experimental respondents thought the MyMAP program
could help other people quit smoking (22/24, 92%) and consistently take their
stop-smoking medication (17/22, 97%) and would recommend the program to others
(20/23, 87%). They also rated the program as convenient, responsive to their
needs, and easy to use. Abstinence rates at 5-month follow-up were 36% in the
experimental arm versus 24% among controls (odds ratio 1.79 [0.61-5.19], P=.42).
Experimental participants used their varenicline an average of 46 days versus 39
among controls (P=.49). More than two-thirds (22/33, 67%) of experimental
participants and three-quarters (25/33, 76%) of controls prematurely discontinued
their varenicline use (P=.29).
CONCLUSIONS: The MyMAP intervention was found to be feasible and acceptable.
Since the study was not powered for statistical significance, no conclusions can
be drawn about the program's effects on smoking abstinence or medication
adherence, but the overall study results suggest further evaluation in a larger
randomized trial is warranted.
CLINICALTRIAL: ClinicalTrials.gov NCT02136498;
https://clinicaltrials.gov/ct2/show/NCT02136498 (Archived by WebCite at
http://www.webcitation.org/6jT3UMFLj).
DOI: 10.2196/mhealth.6002
PMCID: PMC4989120
PMID: 27489247
Pandey A(1), Raza F(2), Velasco A(3), Brinker S(2), Ayers C(4), Das SR(1),
Morisky DE(5), Halm EA(2), Vongpatanasin W(6).
Author information:
(1)Cardiology Division, University of Texas Southwestern Medical Center, Dallas,
TX, USA.
(2)Internal Medicine Department, University of Texas Southwestern Medical Center,
Dallas, TX, USA.
(3)Hypertension Section, University of Texas Southwestern Medical Center, Dallas,
TX, USA.
(4)Department of Clinical Science, University of Texas Southwestern Medical
Center, Dallas, TX, USA.
(5)Department of Community Health Sciences, Univeristy of California, Los
Angeles, Fielding School of Public Health, Los Angeles, CA, USA.
(6)Cardiology Division, University of Texas Southwestern Medical Center, Dallas,
TX, USA; Hypertension Section, University of Texas Southwestern Medical Center,
Dallas, TX, USA. Electronic address: wanpen.vongpatanasin@utsouthwestern.edu.
DOI: 10.1016/j.jash.2015.04.004
PMID: 26051923 [Indexed for MEDLINE]
Author information:
(1)Institute for Research on Women and Gender and Substance Abuse Research
Center, University of Michigan, Ann Arbor. Electronic address: plius@umich.edu.
(2)Institute for Research on Women and Gender.
(3)Institute for Social Research, Survey Research Center, University of Michigan.
(4)Pediatric and Adult Psychopharmacology Units, Massachusetts General Hospital,
Boston and School of Medicine, Harvard University, Boston.
DOI: 10.1016/j.jaac.2016.03.011
PMCID: PMC4921895
PMID: 27238066 [Indexed for MEDLINE]
Tecla: a telephone- and text-message based telemedical concept for patients with
severe mental health disorders--study protocol for a controlled, randomized,
study.
Stentzel U(1), Grabe HJ(2), Strobel L(3), Penndorf P(4), Langosch J(5),
Freyberger HJ(6), Hoffmann W(7), van den Berg N(8).
Author information:
(1)Institute for Community Medicine, University Medicine Greifswald,
Ellernholzstraße 1-2, 17487, Greifswald, Germany.
ulrike.stentzel@uni-greifswald.de.
(2)Department of Psychiatry and Psychotherapy, University Medicine Greifswald,
Ellernholzstraße 1-2, 17487, Greifswald, Germany. grabeh@uni-greifswald.de.
(3)Department of Psychiatry and Psychotherapy, University Medicine Greifswald,
Ellernholzstraße 1-2, 17487, Greifswald, Germany. lara.strobel@uni-greifswald.de.
(4)Institute for Community Medicine, University Medicine Greifswald,
Ellernholzstraße 1-2, 17487, Greifswald, Germany.
peter.penndorf@uni-greifswald.de.
(5)Bethanien Hospital for Psychiatry, Psychosomatics and Psychotherapy, Gützkower
Landstraße 69, 17489, Greifswald, Germany. langosch@odebrecht-stiftung.de.
(6)Department of Psychiatry and Psychotherapy, University Medicine Greifswald,
Ellernholzstraße 1-2, 17487, Greifswald, Germany. freyberg@uni-greifswald.de.
(7)Institute for Community Medicine, University Medicine Greifswald,
Ellernholzstraße 1-2, 17487, Greifswald, Germany.
wolfgang.hoffmann@uni-greifswald.de.
(8)Institute for Community Medicine, University Medicine Greifswald,
Ellernholzstraße 1-2, 17487, Greifswald, Germany.
neeltje.vandenberg@uni-greifswald.de.
DOI: 10.1186/s12888-015-0659-7
PMCID: PMC4634903
PMID: 26537570 [Indexed for MEDLINE]
Author information:
(1)Program in Public Health, Department of Health Services, Policy & Practice,
Brown University, Box G-121-6, 121 South Main Street, Providence, RI, 02912, USA,
becky_genberg@brown.edu.
The objectives of this study were to understand how different types of barriers
to adherence to antiretroviral therapy (ART) were related and their differential
impact on objectively measured adherence over time. Data from 151 patients taking
ART were used to describe four sub-types of self-reported adherence barriers:
medication and health concerns (MHC), stigma (S), family responsibilities (FR),
and problems with schedule and routine (PSR). Generalized linear models with
generalized estimating equations (GEE) were used to examine the impact of
barriers on adherence over time. The sample was 23 % female, mean age 42 years,
with 26 % African-American and 20 % Hispanic. The overall average adherence was
73 %. Patients reported at least one PSR barrier in 66 % of study visits, MHC in
40 %, S in 17 %, and FR in 6 %. In 40 % of visits, patients reported two or more
barrier sub-types. There were statistically significant (p ≤ 0.05) decreases of
3.9, 2.5, and 2.4 in percent adherence, for MHC, PSR, and S, respectively, per
unit increase in barrier score. Interventions to address different types of
patient-identified barriers to ART adherence using targeted approaches are
needed.
DOI: 10.1007/s10461-014-0775-2
PMCID: PMC4203705
PMID: 24748240 [Indexed for MEDLINE]
Sato M(1), Tsujimoto M(2), Kajimoto K(2), Uetake H(3), Shimoda H(3), Fujiwara
S(4).
Author information:
(1)Medicines Development Unit Japan, Eli Lilly Japan K.K, Kobe, Hyogo, Japan.
sato_masayo@lilly.com.
(2)Medicines Development Unit Japan, Eli Lilly Japan K.K, Kobe, Hyogo, Japan.
(3)Statistical Analysis Department, CDM Division, CMIC Co., Ltd., Tokyo, Japan.
(4)Health Management and Promotion Center, Hiroshima Atomic Bomb Casualty
Council, Hiroshima, Japan.
DOI: 10.1007/s11657-018-0487-8
PMCID: PMC6310708
PMID: 29978364 [Indexed for MEDLINE]
Mandimika N(1), Barnes KI(1), Chandler CI(2), Pace C(3), Allen EN(4).
Author information:
(1)Division of Clinical Pharmacology, Department of Medicine, University of Cape
Town, Cape Town, South Africa.
(2)Department of Global Health & Development, London School of Hygiene & Tropical
Medicine, London, UK.
(3)Department of Clinical Sciences, Liverpool School of Tropical Medicine,
Liverpool, UK.
(4)Division of Clinical Pharmacology, Department of Medicine, University of Cape
Town, Cape Town, South Africa. elizabeth.allen@uct.ac.za.
BACKGROUND: Eliciting adverse event (AE) and non-study medication data reports
from clinical research participants is integral to evaluating drug safety.
However, using different methods to question participants yields inconsistent
results, compromising the interpretation, comparison and pooling of data across
studies. This is particularly important given the widespread use of
anti-malarials in vulnerable populations, and their increasing use in healthy,
but at-risk individuals, as preventive treatment or to reduce malaria
transmission.
METHODS: Experienced and knowledgeable anti-malarial drug clinical researchers
were invited to participate in a Delphi technique study, to facilitate consensus
on what are considered optimal (relevant, important and feasible) methods, tools,
and approaches for detecting participant-reported AE and non-study medication
data in uncomplicated malaria treatment studies.
RESULTS: Of 72 invited, 25, 16 and 10 panellists responded to the first, second
and third rounds of the Delphi, respectively. Overall, 68% (68/100) of all
questioning items presented for rating achieved consensus. When asking general
questions about health, panellists agreed on the utility of a question/concept
about any change in health, taking care to ensure that such questions/concepts do
not imply causality. Eighty-nine percent (39/44) of specific signs and symptoms
questions were rated as optimal. For non-study medications, a general question
and most structured questioning items were considered an optimal approach. The
use of mobile phones, patient diaries, rating scales as well as openly engaging
with participants to discuss concerns were also considered optimal complementary
data-elicitation tools.
CONCLUSIONS: This study succeeded in reaching consensus within a section of the
anti-malarial drug clinical research community about using a general question
concept, and structured questions for eliciting data about AEs and non-study
medication reports. The concepts and items considered in this Delphi to be
relevant, important and feasible should be further investigated for potential
inclusion in a harmonized approach to collect participant-elicited anti-malarial
drug safety data. This, in turn, should improve understanding of anti-malarial
drug safety.
DOI: 10.1186/s12936-017-1699-x
PMCID: PMC5273807
PMID: 28129765 [Indexed for MEDLINE]
1566. J Comp Eff Res. 2016 Mar;5(2):155-68. doi: 10.2217/cer.15.60. Epub 2016 Mar
7.
Feldman PH(1), McDonald MV(1), Barrón Y(1), Gerber LM(2), Peng TR(1).
Author information:
(1)Center for Home Care Policy & Research, Visiting Nurse Service of New York,
New York, NY 10021, USA.
(2)Department Healthcare Policy & Research, Weill Cornell Medical College, New
York, NY 10065, USA.
AIM: Assess the comparative effectiveness of two blood pressure (BP) control
interventions for black patients with uncontrolled hypertension.
PATIENTS & METHODS: A total of 845 patients were enrolled in a three-arm cluster
randomized trial. On admission of an eligible patient, field nurses were
randomized to usual care, a basic or augmented intervention.
RESULTS: Across study arms there were no significant 12 months differences in BP
control rates (primary outcome) (25% usual care, 26% basic intervention, 22%
augmented intervention); systolic BP (143.8 millimeters of mercury [mmHg], 146.9
mmHG, 143.9 mmHG, respectively); medication intensification (47, 43, 54%,
respectively); or self-management score (18.7, 18.7, 17.9, respectively).
Adjusted systolic BP dropped more than 10 mmHg from baseline to 12 months
(155.5-145.4 mmHg) among all study participants.
CONCLUSION: Neither the augmented nor basic intervention was more effective than
usual care in improving BP control, systolic BP, medication intensification or
patient self-management. Usual home care yielded substantial improvements,
creating a high comparative effectiveness threshold.
CLINICAL TRIAL REGISTRATION: NCT00139490.
DOI: 10.2217/cer.15.60
PMCID: PMC5543816
PMID: 26946952 [Indexed for MEDLINE]
Malta DC(1), Gonçalves RPF(1), Machado ÍE(1), Freitas MIF(1), Azeredo C(2),
Szwarcwald CL(3).
Author information:
(1)Escola de Enfermagem, Universidade Federal de Minas Gerais - Belo Horizonte
(MG), Brasil.
(2)Coordenação de Trabalho e Rendimento, Instituto Brasileiro de Geografia e
Estatística - Rio de Janeiro (RJ), Brasil.
(3)Instituto de Comunicação e Informação Científica e Tecnológica em Saúde,
Fundação Oswaldo Cruz - Rio de Janeiro (RJ), Brasil.
1568. Open Forum Infect Dis. 2018 Apr 26;5(4):ofy046. doi: 10.1093/ofid/ofy046.
eCollection 2018 Apr.
Author information:
(1)Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore,
Maryland.
(2)Baltimore City Health Department, Baltimore, Maryland.
DOI: 10.1093/ofid/ofy046
PMCID: PMC5917780
PMID: 29732378
1569. BMJ Qual Improv Rep. 2015 Jun 8;4(1). pii: u208804.w3544. doi:
10.1136/bmjquality.u208804.w3544. eCollection 2015.
Jeffrey J(1).
Author information:
(1)UCLA, USA.
This resident physician-led quality improvement project was conducted with aims
to improve the health of youth prescribed atypical antipsychotic medications by
increasing physician monitoring for metabolic side effects, while simultaneously
educating trainees in quality improvement methodology. The plan, do, study, act
quality improvement framework was utilized. Baseline metabolic monitoring rates
of patients prescribed atypical antipsychotic medications in the two psychiatry
resident outpatient clinics were obtained. Rates were stratified based on time on
medication (<1 year, ≥1 year) and parameter monitored. Metabolic monitoring rates
subsequent to targeted changes were obtained. Problem solving with residents
revealed barriers to monitoring, such as limited awareness of specific guideline
recommendations and lack of convenient access to medical equipment (calibrated
scales). Residents received education about atypical antipsychotic monitoring
guidelines and side effect treatment. Residents were provided with calibrated
scales. Atypical antipsychotic monitoring templates were introduced. Online
surveys using were conducted to determine self-reported baseline-monitoring rates
and comfort with guidelines following targeted change. The baseline metabolic
monitoring rates of patients prescribed atypical antipsychotic medications was 9%
(range: 0 to 17.6%) for youth in their first year taking an atypical
antipsychotic medication and 58.9% (range: 29% to 100%) in subsequent years on
medication. The results of relatively easy changes resulted in modest improvement
in monitoring rates. The metabolic monitoring rate of a patient initiated on an
atypical antipsychotic medication was 29% after targeted quality improvement
measures were employed. Following quality improvement changes, residents reported
increased knowledge about guidelines and increased monitoring for side effects.
Use of a standardized data collection instrument to track monitoring of patients
increased from 0% to 70% (range: 30% to 90%). Quality improvement projects
provide an avenue with which to improve atypical antipsychotic monitoring rates.
Through active participation in quality improvement projects, psychiatry
residents may be taught to employ quality improvement methodology.
DOI: 10.1136/bmjquality.u208804.w3544
PMCID: PMC4645906
PMID: 26734359
Aspden T(1), Wolley MJ(2), Ma TM(3), Rajah E(4), Curd S(5), Kumar D(6), Lee S(7),
Pireva K(8), Taule'alo O(9), Tiavale P(10), Kam AL(11), Suh JS(12), Kennedy
J(13), Marshall MR(14).
Author information:
(1)School of Pharmacy, Faculty of Medical and Health Sciences, The University of
Auckland, 85 Park Rd, Auckland, 1142, New Zealand. t.aspden@auckland.ac.nz.
(2)School of Medicine, University of Queensland, 288 Herston Road, Brisbane,
4006, Australia. martin.wolley@gmail.com.
(3)Department of Renal Medicine, Counties Manukau District Health Board, Hospital
Road, Otahuhu, Auckland, 1640, New Zealand. maggiema.aut@gmail.com.
(4)Marketing Department, Faculty of Business, Auckland University of Technology,
46 Wakefield St, Auckland, 1010, New Zealand. erajah@aut.ac.nz.
(5)Formerly of the School of Pharmacy, Faculty of Medical and Health Sciences,
The University of Auckland, 85 Park Rd, Auckland, 1142, New Zealand.
samlouisecurd@gmail.com.
(6)Formerly of the School of Pharmacy, Faculty of Medical and Health Sciences,
The University of Auckland, 85 Park Rd, Auckland, 1142, New Zealand.
dharni_k91@hotmail.com.
(7)Formerly of the School of Pharmacy, Faculty of Medical and Health Sciences,
The University of Auckland, 85 Park Rd, Auckland, 1142, New Zealand.
sophia.lee2404@gmail.com.
(8)Formerly of the School of Pharmacy, Faculty of Medical and Health Sciences,
The University of Auckland, 85 Park Rd, Auckland, 1142, New Zealand.
krenny_p@hotmail.com.
(9)Formerly of the School of Pharmacy, Faculty of Medical and Health Sciences,
The University of Auckland, 85 Park Rd, Auckland, 1142, New Zealand.
olita_85@hotmail.com.
(10)Formerly of the School of Pharmacy, Faculty of Medical and Health Sciences,
The University of Auckland, 85 Park Rd, Auckland, 1142, New Zealand.
pjtiavale@gmail.com.
(11)Pharmacy Services, Counties Manukau District Health Board, Hospital Road,
Otahuhu, Auckland, 1640, New Zealand. angela.kam@middlemore.co.nz.
(12)Department of Renal Medicine, Counties Manukau District Health Board,
Hospital Road, Otahuhu, Auckland, 1640, New Zealand. junssuh@gmail.com.
(13)School of Pharmacy, Faculty of Medical and Health Sciences, The University of
Auckland, 85 Park Rd, Auckland, 1142, New Zealand. julia.kennedy@auckland.ac.nz.
(14)School of Medicine, Faculty of Medical and Health Sciences, The University of
Auckland, 85 Park Rd, Auckland, 1142, New Zealand. mrmarsh@woosh.co.nz.
DOI: 10.1186/s12882-015-0097-2
PMCID: PMC4499205
PMID: 26162369 [Indexed for MEDLINE]
1571. Integr Cancer Sci Ther. 2015 Dec;2(6):300-304. Epub 2015 Nov 6.
Risk factors for cost-related medication non-adherence among older patients with
cancer.
Author information:
(1)Section of Hospital Medicine, Department of Medicine, The University of
Chicago, USA.
(2)Section of Hospital Medicine, Department of Medicine, The University of
Chicago, USA; Department of Economics, The University of Chicago, USA; Harris
School of Public Policy, The University of Chicago, USA.
PMCID: PMC4827776
PMID: 27087984
Jump starting shared medical appointments for diabetes with weight management:
Rationale and design of a randomized controlled trial.
Crowley MJ(1), Edelman D(2), Voils CI(2), Maciejewski ML(2), Coffman CJ(2),
Jeffreys AS(3), Turner MJ(3), Gaillard LA(3), Hinton TA(3), Strawbridge E(3),
Zervakis J(3), Barton AB(4), Yancy WS Jr(5).
Author information:
(1)Center for Health Services Research in Primary Care, Durham VA Medical Center,
Durham, NC, United States; Department of Medicine, Division of Endocrinology,
Duke University Medical Center, Durham, NC, United States. Electronic address:
matthew.crowley@dm.duke.edu.
(2)Center for Health Services Research in Primary Care, Durham VA Medical Center,
Durham, NC, United States; Department of Medicine, Division of General Internal
Medicine, Duke University Medical Center, Durham, NC, United States.
(3)Center for Health Services Research in Primary Care, Durham VA Medical Center,
Durham, NC, United States.
(4)Department of Medicine, Division of Endocrinology, Duke University Medical
Center, Durham, NC, United States.
(5)Center for Health Services Research in Primary Care, Durham VA Medical Center,
Durham, NC, United States; Department of Medicine, Division of General Internal
Medicine, Duke University Medical Center, Durham, NC, United States; Duke Diet
and Fitness Center, Durham, NC, United States.
DOI: 10.1016/j.cct.2017.04.004
PMCID: PMC5505724
PMID: 28445783 [Indexed for MEDLINE]
Sluggett JK(1)(2), Page AT(1), Chen EYH(1)(2), Ilomäki J(1)(3), Corlis M(2)(4),
Van Emden J(2)(4), Hogan M(2)(4), Caporale T(4), Angley M(5), Hilmer SN(2)(6),
Ooi CE(1), Bell JS(1)(2)(3)(5).
Author information:
(1)Centre for Medicine Use and Safety, Monash Institute of Pharmaceutical
Sciences, Monash University, Parkville, Victoria, Australia.
(2)National Health and Medical Research Council (NHMRC) Cognitive Decline
Partnership Centre, Hornsby Ku-ring-gai Hospital, Hornsby, New South Wales,
Australia.
(3)Department of Epidemiology and Preventive Medicine, School of Public Health
and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
(4)Research and Development, Helping Hand Aged Care, North Adelaide, South
Australia, Australia.
(5)School of Pharmacy and Medical Sciences, University of South Australia,
Adelaide, South Australia, Australia.
(6)Kolling Institute of Medical Research, Royal North Shore Hospital, Northern
Clinical School, Faculty of Medicine and Health, The University of Sydney,
Sydney, New South Wales, Australia.
Lentz SR(1), Rangarajan S, Karim FA, Andersen PD, Arkhammar P, Rosu G, Mahlangu
J.
Author information:
(1)aDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
bNorth Hampshire Haemophilia Centre, Basingstoke, UK cNational Blood Centre,
Kuala Lumpur, Malaysia dNovo Nordisk A/S, Søborg, Denmark eFaculty of Health
Science, University of the Witwatersrand, and NHLS, Johannesburg, South Africa.
DOI: 10.1097/MBC.0000000000000584
PMCID: PMC5407628
PMID: 27427786 [Indexed for MEDLINE]
1575. Eur Thyroid J. 2015 Jun;4(2):93-8. doi: 10.1159/000381768. Epub 2015 May 27.
Author information:
(1)Department of Clinical Science and Education, Section of Endocrinology,
Karolinska Institutet, Södersjukhuset, Uppsala, Sweden.
(2)Department of Medicine, Mälarsjukhuset, Eskilstuna, Uppsala, Sweden ; Centre
for Clinical Research in Sörmland, Uppsala University, Uppsala, Sweden.
(3)National Food Institute, Technical University of Denmark, Søborg, Denmark.
(4)Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital,
Stockholm, Uppsala, Sweden ; Centre for Clinical Research in Sörmland, Uppsala
University, Uppsala, Sweden.
DOI: 10.1159/000381768
PMCID: PMC4521074
PMID: 26279994
PMCID: PMC4962557
PMID: 27070004 [Indexed for MEDLINE]
1577. Health Qual Life Outcomes. 2017 Mar 14;15(1):50. doi: 10.1186/s12955-017-
0622-z.
Author information:
(1)University Medical Centre Groningen, Department of Community and Occupational
Medicine, University Groningen, Antonius Deusinglaan 1, 9713, AV, Groningen, The
Netherlands. p.j.h.jongen@rug.nl.
(2)MS4 Research Institute, Ubbergseweg 34, 6522, KJ, Nijmegen, The Netherlands.
p.j.h.jongen@rug.nl.
(3)Department for Health Evidence, Radboud University Medical Centre, P.O. Box
9101, 6500, HB, Nijmegen, The Netherlands.
(4)St. Antonius Hospital, P.O. Box 2500, 3430, EM, Nieuwegein, The Netherlands.
DOI: 10.1186/s12955-017-0622-z
PMCID: PMC5351176
PMID: 28292329 [Indexed for MEDLINE]
Stürup AE(1)(2), Jensen HD(3), Dolmer S(4), Birk M(4), Albert N(3), Nielsen M(4),
Hjorthøj C(3), Eplov L(3), Ebdrup BH(5), Mors O(4), Nordentoft M(3)(6).
Author information:
(1)Copenhagen University Hospital, Mental Health Center Copenhagen, Kildegårsvej
28, opg. 15 4. sal, 2900, Hellerup, Denmark. anne.emilie.stuerup@regionh.dk.
(2)University of Copenhagen, Institute for Clinical Medicine, Faculty of Health
and Medical Science, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.
anne.emilie.stuerup@regionh.dk.
(3)Copenhagen University Hospital, Mental Health Center Copenhagen, Kildegårsvej
28, opg. 15 4. sal, 2900, Hellerup, Denmark.
(4)Psychosis Research Unit, Aarhus University Hospital, Skovagervej 2, 8240,
Risskov, Denmark.
(5)Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research
(CINS) and Centre for Neuropsychiatric Schizophrenia Research (CNSR), Mental
Health Centre Glostrup, Copenhagen University Hospital, Nordre Ringvej 69, 2600,
Glostrup, Denmark.
(6)University of Copenhagen, Institute for Clinical Medicine, Faculty of Health
and Medical Science, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.
BACKGROUND: The aim of the TAILOR trial is to investigate the effect of closely
monitored tapering/discontinuation versus maintenance therapy with antipsychotic
medication in patients with newly diagnosed schizophrenia or persistent
delusional disorder and with minimum 3 months' remission of psychotic symptoms.
METHODS AND DESIGN: Two hundred and fifty patients will be included from the
psychiatric early intervention program, OPUS, in two regions in Denmark.
Inclusion criteria are: ICD-10 diagnoses schizophrenia (F20, except F20.6) or
persistent delusional disorder (F22), minimum 3 months' remission of psychotic
symptoms and in treatment with antipsychotic medication (except clozapine). The
patients will be randomized to maintenance therapy or tapering/discontinuation
with antipsychotic medication in a 1-year intervention. The
tapering/discontinuation group will be using a smartphone application to monitor
early warning signs of psychotic relapse. Patients will be assessed at baseline,
1-, 2- and 5-year follow-up regarding psychotic and negative symptoms,
side-effects of antipsychotic medication, social functioning, cognitive
functioning, perceived health status, patient satisfaction, substance and alcohol
use, sexual functioning and quality of life. The primary outcome will be
remission of psychotic symptoms and no antipsychotic medication after 1 year.
Secondary outcome measures will include: co-occurrence of remission of psychotic
symptoms and 0-1-mg haloperidol equivalents of antipsychotic medication after
1-year intervention; antipsychotic dose; antipsychotic side effects; negative
symptoms; social functioning; cognitive functioning; and patient satisfaction.
Exploratory outcomes will include remission, clinical recovery, substance and
alcohol use, sexual functioning, quality of life, self-beliefs of coping and user
experience of support from health workers. Safety measures will include death,
admissions to psychiatric hospital, severe self-harm and psychotic relapses.
DISCUSSION: The TAILOR trial will contribute knowledge about the effect of
tapering/discontinuation of antipsychotic medication in the early phases of
schizophrenia and related disorders and the results may guide future clinical
treatment regimens of antipsychotic treatment.
TRIAL REGISTRATION: EU Clinical Trials Register - EudraCT number: 2016-000565-23
. Registered on 5 February 2016.
DOI: 10.1186/s13063-017-2172-4
PMCID: PMC5622425
PMID: 28962668 [Indexed for MEDLINE]
Morton K(1), Dennison L(1), Bradbury K(1), Band RJ(1), May C(2), Raftery J(3),
Little P(4), McManus RJ(5), Yardley L(1).
Author information:
(1)Academic Unit of Psychology, University of Southampton, Southampton, UK.
(2)Faculty of Health Sciences, University of Southampton, Southampton, UK.
(3)Faculty of Medicine, Southampton University, Southampton, UK.
(4)Primary Care Research, University of Southampton, Southampton, UK.
(5)Nuffield Department of Primary Care Health Sciences, University of Oxford,
Oxford, UK.
© Article author(s) (or their employer(s) unless otherwise stated in the text of
the article) 2018. All rights reserved. No commercial use is permitted unless
otherwise expressly granted.
DOI: 10.1136/bmjopen-2017-020843
PMCID: PMC5942415
PMID: 29739782 [Indexed for MEDLINE]
Moncrieff J(1), Azam K(2), Johnson S(3), Marston L(4), Morant N(3), Darton K(5),
Wood N(6).
Author information:
(1)Division of Psychiatry, University College London, Maple House, 149 Tottenham
Court Road, London, W1T 7NF, UK. j.moncrieff@ucl.ac.uk.
(2)North East London Foundation Trust, Research & Development Department,
Goodmayes Hospital, Barley Lane, Ilford, Essex, IG3 8XJ, UK.
(3)Division of Psychiatry, University College London, Maple House, 149 Tottenham
Court Road, London, W1T 7NF, UK.
(4)Department of Primary Care and Population Health and Priment Clinical Trials
Unit, University College London, Rowland Hill Street, London, NE3 2PF, UK.
(5)Mind, 15-19 Broadway, Stratford, London, E15 4BQ, UK.
(6)Goodmayes Hospital, Barley Lane, Ilford, Essex, IG3 8XJ, UK.
DOI: 10.1186/s12888-016-0921-7
PMCID: PMC4932750
PMID: 27377549 [Indexed for MEDLINE]
Searle A(1), Ranger E(2), Zahra J(3), Tibbitts B(4), Page A(5), Cooper A(5).
Author information:
(1)Senior Research Associate, BRC Nutrition Theme School of Oral and Dental
Science, University of Bristol Education and Research Centre, Bristol, UK
A.J.Searle@bristol.ac.uk.
(2)PhD Student, Centre for Exercise, Nutrition and Health Sciences School for
Policy Studies, University of Bristol, Bristol, UK.
(3)Senior Research Associate, BRC Nutrition Theme School of Oral and Dental
Science, University of Bristol Education and Research Centre, Bristol, UK.
(4)Senior Research Associate, Centre for Exercise, Nutrition and Health Sciences
School for Policy Studies, University of Bristol, Bristol, UK.
(5)Professor of Physical Activity and Public Health, Centre for Exercise,
Nutrition and Health Sciences School for Policy Studies, University of Bristol,
Bristol, UK.
DOI: 10.3399/bjgpopen18X101638
PMCID: PMC6662872
PMID: 31366669
Diabetes accounts for the second largest amount of avoidable healthcare costs in
the United States-an estimated $24.6 billion in wasteful and avoidable spending.
Diabetes is a lifelong disease that is highly dependent on patient
self-management. Unfortunately, studies demonstrate that almost 50% of patients
with diabetes fail to reach the glycemic goal of glycated hemoglobin <7%. Patient
nonadherence poses a significant barrier to effective management of diabetes and
can place a significant burden on the patient and the healthcare system,
resulting in even greater increases in costs, morbidity, and mortality.
Therefore, effective treatment and long-term management of diabetes requires a
patient-centered collaborative model of care with an understanding of the factors
associated with nonadherence. This may help develop patient-, provider-, and
system-focused strategies to help increase the rates of medication adherence,
reduce complications associated with uncontrolled diabetes, and lower the overall
cost of management.
Chavan GM(1), Waghachavare VB(1), Gore AD(1), Chavan VM(1), Dhobale RV(1),
Dhumale GB(1).
Author information:
(1)Department of Community Medicine, Bharati Vidyapeeth Deemed University Medical
College and Hospital, Sangli, Maharashtra, India.
DOI: 10.4103/2249-4863.161349
PMCID: PMC4535111
PMID: 26288789
Suboxone Treatment and Recovery Trial (STAR-T): Study Protocol for a Randomised
Controlled Trial of Opioid Medication Assisted Treatment with Adjunctive
Medication Management Using Therapeutic Drug Monitoring and Contingency
Management.
Elarabi H(1)(2), Elrasheed A(2), Ali A(2), Shawky M(2), Hasan N(2), Gawad TA(2),
Adem A(3), Marsden J(4).
Author information:
(1)Addictions Department, Institute of Psychiatry, Psychology and Neurosciences,
King's College London, 4-Windsor Walk, ASB, Denmark Hill, SE5 8BB, London, UK.
(2)National Rehabilitation Centre, UAE, P.O. Box 55001, Abu Dhabi, Shakhboot
City, UAE.
(3)College of Medicine and Health Sciences, United Arab Emirates University, P.O.
Box 15551, Alain, AD, UAE.
(4)Addictions Department, Institute of Psychiatry, Psychology and Neurosciences,
King's College London, Addiction Sciences Building, 4 Windsor Walk, Demark Hill,
London, Denmark Hill, SE5 8AF, UK.
DOI: 10.1155/2019/2491063
PMCID: PMC6425325
PMID: 30956839
Sieben A(1), van Onzenoort HA, van Laarhoven KJ, Bredie SJ.
Author information:
(1)Radboud University Nijmegen Medical Centre, Department of Surgery, Division of
Vascular Surgery, Radboud University Nijmegen Medical Centre, Nijmegen,
Netherlands. angelien.sieben@radboudumc.nl.
DOI: 10.2196/resprot.5750
PMCID: PMC5039334
PMID: 27624877
Author information:
(1)BPharm (Hons) UKM Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan
Raja Muda Abdul Aziz 50300 Kuala Lumpur, Malaysia.
(2)(Corresponding author) RPh, BPharm (Hons) (UKM), MClinPharm (UKM), PhD
(Australia) Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda
Abdul Aziz, 50300 Kuala Lumpur, Malaysia Email: marhanis@ukm.edu.my.
PMCID: PMC5842418
PMID: 29527274
Sutton S(1), Kinmonth AL, Hardeman W, Hughes D, Boase S, Prevost AT, Kellar I,
Graffy J, Griffin S, Farmer A.
Author information:
(1)Behavioural Science Group, Primary Care Unit, Department of Public Health and
Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK,
srs34@medschl.cam.ac.uk.
Comment in
Ann Behav Med. 2014 Dec;48(3):287-8.
DOI: 10.1007/s12160-014-9595-x
PMCID: PMC4223537
PMID: 24573909 [Indexed for MEDLINE]
Author information:
(1)CHU Sainte-Justine, Université de Montreal, 3175 Chemin de la
Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
(2)CHU Sainte-Justine, Université de Montreal, 3175 Chemin de la
Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada. serge.sultan@umontreal.ca.
DOI: 10.1186/s12887-016-0542-9
PMCID: PMC4707725
PMID: 26754457 [Indexed for MEDLINE]
1589. BMC Complement Altern Med. 2017 Apr 4;17(1):196. doi: 10.1186/s12906-017-
1714-3.
Prevalence, knowledge and attitudes toward herbal medication use by Saudi women
in the central region during pregnancy, during labor and after delivery.
Al-Ghamdi S(1), Aldossari K(2), Al-Zahrani J(2), Al-Shaalan F(3), Al-Sharif S(3),
Al-Khurayji H(3), Al-Swayeh A(3).
Author information:
(1)Department of Family Medicine, College of Medicine, Prince Sattam bin
Abdulaziz University, Al Kharj, Saudi Arabia. sam3443@gmail.com.
(2)Department of Family Medicine, College of Medicine, Prince Sattam bin
Abdulaziz University, Al Kharj, Saudi Arabia.
(3)College of Medicine, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi
Arabia.
DOI: 10.1186/s12906-017-1714-3
PMCID: PMC5379727
PMID: 28376788 [Indexed for MEDLINE]
Author information:
(1)Department of Nursing, University of Social Welfare and Rehabilitation
Sciences, Tehran, Iran.
(2)Associate Professor, Iranian Research Center on Aging AND Department of
Nursing Education, University of Social Welfare and Rehabilitation Sciences,
Tehran, Iran.
(3)Associate Professor, Department of Nursing, University of Social Welfare and
Rehabilitation Sciences, Tehran, Iran.
(4)Professor, Department of Nursing, University of Social Welfare and
Rehabilitation Sciences, Tehran, Iran.
(5)Professor, Behavioral Sciences Research Center, Lifestyle Institute, School of
Nursing, Baqiyatallah University of Medical Sciences, Tehran, Iran.
DOI: 10.22122/arya.v15i2.1807
PMCID: PMC6679658
PMID: 31440290
Author information:
(1)Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of
Medicine at Mount Sinai, New York, NY, USA, melissa.garrido@mssm.edu.
DOI: 10.1007/s11414-013-9342-2
PMCID: PMC3883894
PMID: 23702612 [Indexed for MEDLINE]
Bandi P(1), Goldmann E(2), Parikh NS(2), Farsi P(2), Boden-Albala B(2)(3)(4).
Author information:
(1)College of Global Public Health, New York University, 665 Broadway, 11th
Floor, New York, NY 10003. Email: pb1349@nyu.edu.
(2)College of Global Public Health, New York University, New York, New York.
(3)Department of Neurology, School of Medicine, Langone Medical Center, New York
University, New York, New York.
(4)Department of Epidemiology and Health Promotion, College of Dentistry, New
York University, New York, New York.
DOI: 10.5888/pcd14.160512
PMCID: PMC5510304
PMID: 28704175 [Indexed for MEDLINE]
Author information:
(1)UCL Interaction Centre, University College London, London, UK.
(2)Health Foundation, London, UK.
(3)School of Healthcare, University of Leeds, Leeds, UK.
(4)Research Department of Practice and Policy, UCL School of Pharmacy, University
College London, London, UK.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://www.bmj.com/company/products-services/rights-and-licensing/
DOI: 10.1136/bmjqs-2015-004670
PMID: 26755665 [Indexed for MEDLINE]
Author information:
(1)Brigham and Women's Hospital, Harvard Medical School, 1620 Tremont St, Ste
3030, Boston, MA 02120. Email: nchoudhry@bwh.harvard.edu.
Jansen J(1)(2), McKinn S(1), Bonner C(1)(2), Muscat DM(1), Doust J(3), McCaffery
K(1)(2).
Author information:
(1)Faculty of Medicine and Health, School of Public Health, Sydney Health
Literacy Lab, The University of Sydney, Sydney, New South Wales, Australia.
(2)Faculty of Medicine and Health, School of Public Health, Wiser Healthcare, The
University of Sydney, Sydney, New South Wales, Australia.
(3)Faculty of Health Sciences and Medicine, Bond University, Gold Coast,
Queensland, Australia.
DOI: 10.1136/bmjopen-2018-026342
PMCID: PMC6475217
PMID: 30898831
Author information:
(1)1Western Michigan University, Kalamazoo, MI USA.
(2)2Department of Psychology, Western Michigan University, Kalamazoo, MI 49008
USA.
People with autism spectrum disorder often receive psychotropic medications and
two drugs, risperidone and aripiprazole, are approved for treating "irritability"
in this population. A number of authors have suggested that behavior analysts can
contribute to the prudent use of such drugs, but little is known regarding Board
Certified Behavior Analysts' involvement in practices relevant to the use of
psychotropic drugs. We e-mailed Board Certified Behavior Analysts an anonymous
web-based survey regarding such practices. A majority of respondents work with
individuals with autism spectrum disorder who take at least one psychotropic
medication but respondents' training relevant to psychotropic medications is
inconsistent. Many report that their training is inadequate, they do not
regularly work as part of interdisciplinary teams concerned with medication, and
behavior-analytic interventions are not typically evaluated before drugs are
prescribed. Nonetheless, the majority of respondents reported that medications
sometimes produce beneficial effects. Those involved in training behavior
analysts should consider the competencies needed for graduates to work
effectively as members of teams concerned with the optimal use of medications and
how to foster and assess those competencies. Behavior analysts should also work
to develop and implement strategies that foster collaboration with psychiatrists
and other physicians. • Psychotropic drugs are often prescribed for people with
autism, and both risperidone and aripiprazole are approved for reducing
"irritability," which comprises self-injury, aggression, tantrums, and other
challenging responses. • Respondents are not consistently involved in monitoring
the effects of psychotropic drugs, which are often administered prior to
evaluating an alternative, less restrictive, intervention. • Respondents are not
trained consistently with respect to matters relevant to psychotropic drugs, and
many apparently are not trained adequately. • People involved in training
behavior analysts should consider the competencies needed for graduates to work
effectively as members of teams concerned with the optimal use of medications and
how to foster and assess those competencies. • Behavior analysts should also work
to develop and implement strategies that foster collaboration with psychiatrists
and other physicians.
DOI: 10.1007/s40617-018-0237-9
PMCID: PMC6269390
PMID: 30538908
Singh S(1), Shekhar C(2), Acharya R(3), Moore AM(4), Stillman M(4), Pradhan
MR(2), Frost JJ(4), Sahoo H(2), Alagarajan M(2), Hussain R(4), Sundaram A(4),
Vlassoff M(4), Kalyanwala S(5), Browne A(4).
Author information:
(1)Guttmacher Institute, New York, NY, USA. Electronic address:
ssingh@guttmacher.org.
(2)International Institute for Population Sciences, Mumbai, India.
(3)Population Council, New York, NY, USA.
(4)Guttmacher Institute, New York, NY, USA.
(5)S Kalyanwala MA is an independent consultant.
Erratum in
Lancet Glob Health. 2017 Dec 12;:.
Comment in
Lancet Glob Health. 2018 Jan;6(1):e16-e17.
Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access
article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights
reserved.
DOI: 10.1016/S2214-109X(17)30453-9
PMCID: PMC5953198
PMID: 29241602 [Indexed for MEDLINE]
Cassell B(1), Gyawali CP(1), Kushnir VM(1), Gott BM(1)(2), Nix BD(1), Sayuk
GS(1)(2)(3).
Author information:
(1)Division of Gastroenterology, Washington University School of Medicine, St
Louis, Missouri, USA.
(2)Department of Psychiatry, Washington University School of Medicine, St Louis,
Missouri, USA.
(3)John Cochran VA Medical Center, St Louis, Missouri, USA.
DOI: 10.1038/ajg.2015.132
PMCID: PMC5051635
PMID: 25916226 [Indexed for MEDLINE]
1599. Eur Heart J Qual Care Clin Outcomes. 2016 Oct 1;2(4):237-244. doi:
10.1093/ehjqcco/qcw018.
Gandapur Y(1), Kianoush S(2), Kelli HM(3), Misra S(2), Urrea B(2), Blaha MJ(2),
Graham G(4)(5), Marvel FA(2), Martin SS(2).
Author information:
(1)Department of Internal Medicine, Good Samaritan/Union Memorial Hospital, 201
East University Parkway, Baltimore, MD 21218, USA.
(2)Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology,
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore,
MD, USA.
(3)Emory Clinical Cardiovascular Research Institute, Emory University School of
Medicine, Atlanta, GA, USA.
(4)Aetna Foundation, Hartford, CT, USA.
(5)University of Connecticut School of Medicine, Farmington, CT, USA.
Comment in
Eur Heart J Qual Care Clin Outcomes. 2016 Oct 1;2(4):231-232.
DOI: 10.1093/ehjqcco/qcw018
PMCID: PMC5862021
PMID: 29474713 [Indexed for MEDLINE]
Tan C(1), Teng GG(2), Chong KJ(3), Cheung PP(2), Lim A(2), Wee HL(4), Santosa
A(2).
Author information:
(1)University Medicine Cluster, Division of Rheumatology, National University
Health System.
(2)University Medicine Cluster, Division of Rheumatology, National University
Health System; Department of Medicine, Yong Loo Lin School of Medicine.
(3)Department of Medicine, Yong Loo Lin School of Medicine.
(4)Department of Pharmacy, Faculty of Science; Saw Swee Hock School of Public
Health, National University of Singapore, Singapore.
Erratum in
Patient Prefer Adherence. 2018 Apr 09;12 :527.
DOI: 10.2147/PPA.S119719
PMCID: PMC5144895
PMID: 27980395
Author information:
(1)Unidad de Trabajo Social y Ciencias para el Desarrollo Humano. Universidad
Autónoma de Tamaulipas. Ciudad Victoria, Tamaulipas, México.
(2)Investigador independiente. Hermosillo, Sonora, México.
(3)Facultad de Psicología. Universidad Autónoma de Nuevo León. Monterrey, NL,
México.
(4)Departamento de Psicología y Ciencias de la Comunicación. Universidad de
Sonora. Hermosillo, Sonora, México.
OBJECTIVE: The objective of this study has been to test the ability of variables
of a psychological model to predict antiretroviral therapy medication adherence
behavior.
METHODS: We have conducted a cross-sectional study among 172 persons living with
HIV/AIDS (PLWHA), who completed four self-administered assessments: 1) the
Psychological Variables and Adherence Behaviors Questionnaire, 2) the
Stress-Related Situation Scale to assess the variable of Personality, 3) The Zung
Depression Scale, and 4) the Duke-UNC Functional Social Support Questionnaire.
Structural equation modeling was used to construct a model to predict medication
adherence behaviors.
RESULTS: Out of all the participants, 141 (82%) have been considered 100%
adherent to antiretroviral therapy. Structural equation modeling has confirmed
the direct effect that personality (decision-making and tolerance of frustration)
has on motives to behave, or act accordingly, which was in turn directly related
to medication adherence behaviors. In addition, these behaviors have had a direct
and significant effect on viral load, as well as an indirect effect on CD4 cell
count. The final model demonstrates the congruence between theory and data
(x2/df. = 1.480, goodness of fit index = 0.97, adjusted goodness of fit index =
0.94, comparative fit index = 0.98, root mean square error of approximation =
0.05), accounting for 55.7% of the variance.
CONCLUSIONS: The results of this study support our theoretical model as a
conceptual framework for the prediction of medication adherence behaviors in
persons living with HIV/AIDS. Implications for designing, implementing, and
evaluating intervention programs based on the model are to be discussed.
DOI: 10.11606/S1518-8787.2017051006926
PMCID: PMC5574467
PMID: 28876412 [Indexed for MEDLINE]
1602. BMC Nurs. 2016 Jan 14;15:4. doi: 10.1186/s12912-015-0121-7. eCollection 2016.
Zaidan M(1), Rustom F(2), Kassem N(3), Al Yafei S(3), Peters L(4), Ibrahim MI(5).
Author information:
(1)Pharmacy Department of NCCCR, and Pharmacy Department of Heart Hospital, Hamad
Medical Corporation, Doha, Qatar.
(2)Pharmacy Department, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
(3)Pharmacy Department NCCCR, Hamad Medical Corporation, Doha, Qatar.
(4)Nursing Department, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
(5)Social & Administrative Pharmacy, College of Pharmacy, Qatar University, PO
Box 2713, Doha, Qatar.
BACKGROUND: Automated dispensing cabinets (ADCs) were introduced in 2010 and 2012
at the Heart Hospital (HH) and National Center for Cancer Care and Research
(NCCCR), both run by Hamad Medical Corporation in Qatar. These medication
distribution systems provide computer-controlled storage, dispensing, and
tracking of drugs at the point of care in patient care units. The purpose of this
study was to assess nurses' perceptions of and satisfaction with the use of ADCs
at HH and NCCCR.
METHODS: A cross-sectional study was conducted in the two institutions in May and
November 2012 using a piloted, validated, online, and anonymous questionnaire.
The questionnaire consisted of four parts: nurses' sociodemographic and practice
characteristics, 21 questions about their perceptions, one question about their
overall satisfaction, and one about the system's ease of use. The
self-administered survey was distributed to 503 nurses working at HH and NCCCR
over three weeks using Survey Monkey®.
RESULTS: The survey response rate was 80 % (n = 403). No significant difference
was found in perception scores between the two institutions (p = 0.06).
Ninety-four percent (n = 378) of nurses agreed that the medication delivery
system allowed them to do their job more safely, and 90 % (n = 363) nurses agreed
that they now spent less time waiting for medication from the pharmacy than they
did before the ADC system was introduced. Eighty seven percent (n = 349) nurses
agreed that they were able to administer medication more efficiently with the ADC
system. The overall satisfaction rate (either "very satisfied" or "satisfied")
for the two hospitals was 91 %.
CONCLUSIONS: The nurses' perceptions of and levels of satisfaction with the ADC
system were very good over the 6 months after complete implementation and
integration at HH and NCCCR. ADCs appear to increase efficiency in the medication
process and should therefore improve the quality of care.
DOI: 10.1186/s12912-015-0121-7
PMCID: PMC4712505
PMID: 26770071
1603. Case Rep Psychiatry. 2017;2017:3701012. doi: 10.1155/2017/3701012. Epub 2017
Sep
10.
Black ER(1).
Author information:
(1)Department of Psychiatry, Southern Illinois University, Springfield, IL 62702,
USA.
DOI: 10.1155/2017/3701012
PMCID: PMC5610788
PMID: 29082058
1604. BMC Health Serv Res. 2018 Oct 11;18(1):772. doi: 10.1186/s12913-018-3572-1.
Author information:
(1)Faculty of Life Sciences and Medicine, School of Population Health &
Environmental Sciences, King's College London, London, UK.
elise.crayton@kcl.ac.uk.
(2)Centre for Behaviour Change, University College London, 1-19 Torrington Place,
London, UK. elise.crayton@kcl.ac.uk.
(3)Centre for Behaviour Change, University College London, 1-19 Torrington Place,
London, UK.
(4)Faculty of Life Sciences and Medicine, School of Population Health &
Environmental Sciences, King's College London, London, UK.
BACKGROUND: Medications targeting stroke risk factors have shown good efficacy,
yet adherence is suboptimal. A lack of underlying theory may contribute to the
ineffectiveness of eliciting or sustaining behaviour change in many existing
interventions targeting medication adherence in stroke. Intervention
effectiveness and implementation could be enhanced by consideration of evidence
base and theory to drive development. The purpose of this study is to identify
appropriate components for a theory-driven and evidence-based medication
adherence intervention for stroke survivors.
METHODS: The Behaviour Change Wheel (BCW), a guide to intervention development,
informed our systematic process of intervention development. Our earlier
systematic review had identified important determinants of medication adherence
that were mapped into the Theoretical Domains Framework (TDF), with Knowledge,
Beliefs about consequences and Emotions found to be more influential. Utilising
the BCW facilitated selection of intervention options and behaviour change
techniques (BCTs); the active ingredients within an intervention. To further
refine BCT selection, APEASE criteria were employed, allowing evaluation of
potential BCTs within context: The National Health Service (NHS), United Kingdom
(UK).
RESULTS: Five intervention functions (Education, Persuasion, Training,
Environmental Restructuring and Enablement) and five policy categories
(Communication/marketing, Guidelines, Regulation, Environmental/social planning
and Service provision) were identified as potential intervention options,
underpinned by our systematic review findings. Application of APEASE criteria led
to an initial pool of 21 BCTs being reduced to 11 (e.g. Habit Formation,
Information about Health Consequences and Action Planning) identified as
potential intervention components that would both be feasible and directly target
the underlying determinants of stroke survivors' medication adherence.
CONCLUSIONS: Careful consideration of underlying evidence and theory to drive
intervention design, facilitated by the BCW, enabled identification of
appropriate intervention components. BCTs including Habit Formation, Information
about Health Consequences and Self-monitoring of Behaviour were considered
potentially effective and appropriate to deliver within the NHS. Having reduced
the pool of potential intervention components to a manageable number, it will now
be possible to explore the perceived acceptability of selected BCTs in interviews
with stroke survivors and healthcare professionals. This approach to intervention
development should be generalisable to other chronic conditions and areas of
behaviour change (e.g. exercise adherence).
DOI: 10.1186/s12913-018-3572-1
PMCID: PMC6182841
PMID: 30309346 [Indexed for MEDLINE]
Author information:
(1)Umeå International School of Public Health, Unit of Epidemiology and Global
Health, Department of Public Health and Clinical Medicine, Faculty of Medicine,
Umeå University, SE-90185, Umeå, Sweden. shingai.gwatidzo@outlook.com.
(2)Unit of Epidemiology and Global Health, Department of Public Health and
Clinical Medicine, Faculty of Medicine, Umeå University, SE-90185, Umeå, Sweden.
(3)Research Centre for Gender, Health and Ageing, Faculty of Health, University
of Newcastle, New Lambton Heights, Newcastle, NSW 2305, New South Wales,
Australia.
DOI: 10.1186/s12877-016-0408-x
PMCID: PMC5225610
PMID: 28077072 [Indexed for MEDLINE]
1606. Innov Clin Neurosci. 2016 Oct 1;13(9-10):12-19. eCollection 2016 Sep-Oct.
Flores GP(1), Peace B(1), Carnes TC(1), Baumgartner SL(1), Buffkin DE Jr(1),
Euliano NR(1), Smith LN(1).
Author information:
(1)Drs. Flores, Carnes, Euliano, Mr. Peace, and Mr. Buffkin are with etectRx,
Inc. in Newberry, Florida; and Drs. Baumgartner and Smith are from Gainesville,
Florida.
PMCID: PMC5141592
PMID: 27974996
Lavan RP(1), Tunceli K(2), Zhang D(2), Normile D(3), Armstrong R(3).
Author information:
(1)Outcomes Research, Animal Health, Center for Observational and Real-World
Evidence, Merck & Co., Inc, Kenilworth, NJ, USA. Robert.lavan@merck.com.
(2)Outcomes Research, Animal Health, Center for Observational and Real-World
Evidence, Merck & Co., Inc, Kenilworth, NJ, USA.
(3)MSD Animal Health, 2 Giralda Farms, Madison, NJ, USA.
DOI: 10.1186/s13071-017-2217-2
PMCID: PMC5460448
PMID: 28583186 [Indexed for MEDLINE]
Author information:
(1)Medical University of Lodz, Department of Infectious Diseases and Hepatology.
BACKGROUND: Antiviral therapies in HIV and chronic HBV infection are lifelong and
require strict adherence to medication to ensure therapeutic success.
AIMS: The aim of this study was to analyze adherence levels in HIV patients on
antiretroviral regimen and in B-infected patients treated with nucleos(t)ide
reverse transcriptase inhibitors.
MATERIAL AND METHODS: The study group consisted of 134 HIV-infected patients and
42 with chronic hepatitis B. The self-reported Morisky 8-Item Medication
Adherence Scale (MMAS-8) was used to assess the adherence to medication. We
analyzed potential predictors of optimal adherence to the antiretroviral therapy.
RESULTS: Mean adherence levels according to MMAS-8 in HIV-infected patients on
antiretroviral therapy was 6.64 (SD+/- 1.47) and was significant lower than in
patients with chronic hepatitis B 7.48 (SD+/- 1.40) (p < 0.0001). However,
adherence levels in HIV-infected patients treated with One-pill-Once a-day
antiretroviral regimen were similar to patients with chronic hepatitis B
(p>0.05). In univariante logistic regression alcohol abstinence, sexual route of
HIV transmission, once daily dosing and reduced number of pills were
significantly associated with high adherence. According to multivariante logistic
regression analysis, only once-daily drug regimen was independent factor of high
adherence (OR=2.89, p=0.038). Higher adherence had positive impact on the
effectiveness of antiretroviral therapy (p=0.04).
CONCLUSIONS: The implementation of once-daily antiretroviral regimen has improved
adherence that had beneficial effect on the effectiveness of antiretroviral
therapy.
Author information:
(1)Faculty of Pharmacy, Department of Pharmacology & Therapeutics, Kuwait
University - Shuwaikh Campus, Shuwaikh, Kuwait.
(2)Faculty of Pharmacy, Department of Pharmacy Practice, Kuwait University -
Shuwaikh Campus, Shuwaikh, Kuwait.
(3)Dasman Diabetes Institute, Kuwait City, Kuwait.
DOI: 10.1136/bmjopen-2018-027395
PMCID: PMC6589008
PMID: 31209092
Conflict of interest statement: Competing interests: None declared.
Biggs MA(1), Ralph L(2), Raifman S(2), Foster DG(2), Grossman D(2).
Author information:
(1)Advancing New Standards in Reproductive Health (ANSIRH), Bixby Center for
Global Reproductive Health, Department of Obstetrics, Gynecology and Reproductive
Sciences, University of California San Francisco, Oakland, CA 94612, USA.
Electronic address: antonia.biggs@ucsf.edu.
(2)Advancing New Standards in Reproductive Health (ANSIRH), Bixby Center for
Global Reproductive Health, Department of Obstetrics, Gynecology and Reproductive
Sciences, University of California San Francisco, Oakland, CA 94612, USA.
OBJECTIVE: The objective was to assess women's personal interest in and support
for three alternative models of medication abortion (MA) provision.
STUDY DESIGN: Using an online survey of a U.S. national, probability-based
representative sample of women ages 18-49, we gauged personal interest in and
general support for three alternative models for accessing abortion pills: (1) in
advance from a doctor for future use, (2) over-the-counter (OTC) from a drugstore
and (3) online without a prescription. We conducted multivariable analyses to
identify characteristics associated with support for these provision models.
RESULTS: Fifty percent (n=7022) of eligible women invited completed the survey.
Nearly half (49%) supported and 30% were personally interested in one or more of
the three access models; 44% supported advance provision, 37% supported OTC
access, and 29% supported online access. Common advantages reported for advance
provision, OTC and online access included privacy (49%, 29% and 46%,
respectively), convenience (38%, 44% and 38%) and being able to end the pregnancy
earlier (48%, 40% and 29%). Common disadvantages included concern that women
might take the pills incorrectly (55%, 53% and 57%), not seeing a clinician
before the abortion (52%, 54% and 53%) and safety (42%, 43% and 60%). History of
abortion and experiencing barriers accessing reproductive health services were
associated with greater support for the alternative models.
CONCLUSION: Women are interested in and support alternative models of MA
provision, in particular, advance provision. However, they also reported concerns
about incorrect pill use and not seeing a clinician beforehand.
IMPLICATIONS: Offering women more choices in how they access medication abortion,
including options where they can safely self-manage their own care, has the
potential to expand access to care.
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.contraception.2018.10.007
PMID: 30448203
1611. Int J Environ Res Public Health. 2019 Aug 23;16(17). pii: E3060. doi:
10.3390/ijerph16173060.
Author information:
(1)Department of Interdisciplinary Health Sciences, College of Allied Health
Sciences, Augusta University, Augusta, GA 30912, USA. prangachari@augusta.edu.
(2)Division of Allergy-Immunology and Pediatric Rheumatology, Department of
Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA 30912,
USA.
(3)Department of Psychiatry & Health Behavior, Medical College of Georgia,
Augusta University, Augusta, GA 30912, USA.
(4)Georgia Prevention Institute, Medical College of Georgia, Augusta University,
Augusta, GA 30912, USA.
(5)Department of Population Health Sciences, Medical College of Georgia, Augusta
University, Augusta, GA 30912, USA.
(6)Department of Interdisciplinary Health Sciences, College of Allied Health
Sciences, Augusta University, Augusta, GA 30912, USA.
(7)Department of Pharmacology & Toxicology, Medical College of Georgia, Augusta
University, Augusta, GA 30912, USA.
(8)Rockefeller College of Public Affairs & Policy, University at Albany, State
University of New York, Albany, NY 12222, USA.
The 2007 U.S. National Institutes of Health EPR-3 guidelines emphasize the
importance creating a provider-patient partnership to enable patients/families to
monitor and take control of their asthma, so that treatment can be adjusted as
needed. However, major shortfalls continue to be reported in provider adherence
to EPR-3 guidelines. For providers to be more engaged in asthma management, they
need a comprehensive set of resources for measuring self-management effectiveness
of asthma, which currently do not exist. In a previously published article in the
Journal of Asthma and Allergy, the authors conducted a literature review, to
develop a holistic framework for understanding self-management effectiveness of
pediatric asthma. The essence of this framework, is that broad socioecological
factors can influence self-agency (patient/family activation), to impact
self-management effectiveness, in children with asthma. A component of
socio-ecological factors of special relevance to providers, would be the quality
of provider-patient/family communication on asthma management. Therefore, the
framework encompasses three key constructs: (1) Provider-patient/family
communication; (2) Patient/family activation; and (3) Self-management
effectiveness. This paper conducts an integrative review of the literature, to
identify existing, validated measures of the three key constructs, with a view to
operationalizing the framework, and discussing its implications for asthma
research and practice.
DOI: 10.3390/ijerph16173060
PMID: 31443605
Geuens J(1), Geurts L(1), Swinnen TW(2)(3), Westhovens R(2)(3), Vanden Abeele
V(1).
Author information:
(1)e-Media Research Lab, Katholieke Universiteit Leuven, Leuven, Belgium.
(2)Division of Rheumatology, Universitaire Ziekenhuizen Gasthuisberg, University
Hospitals Leuven, Leuven, Belgium.
(3)Department of Development and Regeneration, Skeletal Biology and Engineering
Research Center, Katholieke Universiteit Leuven, Leuven, Belgium.
©Jonas Geuens, Luc Geurts, Thijs W Swinnen, Rene Westhovens, Vero Vanden Abeele.
Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org),
25.03.2019.
DOI: 10.2196/12535
PMCID: PMC6452281
PMID: 30907737
"I have nine specialists. They need to swap notes!" Australian patients'
perspectives of medication-related problems following discharge from hospital.
Eassey D(1), McLachlan AJ(1)(2), Brien JA(1), Krass I(1), Smith L(1).
Author information:
(1)Faculty of Pharmacy Camperdown, The University of Sydney, Sydney, NSW,
Australia.
(2)Centre for Education and Research on Ageing, Concord Repatriation General
Hospital, Concord, NSW, Australia.
BACKGROUND: Research has shown that patients are most susceptible to
medication-related problems (MRPs) when transitioning from hospital to home.
Currently, the literature in this area focuses on interventions, which are mainly
orientated around the perspective of the health-care professional and do not take
into account patient perspectives and experiences.
OBJECTIVE: To capture the experiences and perceptions of Australian patients
regarding MRPs following discharge from hospital.
DESIGN: A cross-sectional study was conducted using a questionnaire collecting
quantitative and qualitative data. Thematic analysis was conducted of the
qualitative data.
SETTING AND PARTICIPANTS: Survey participants were recruited through The Digital
Edge, an online market research company. Five hundred and six participants
completed the survey.
RESULTS: A total of 174 participants self-reported MRPs. Two concepts and seven
subthemes emerged from the analysis. The first concept was types of MRPs and
patient experiences. Three themes were identified: unwanted effects from
medicines, confusion about medicines and unrecognized medicines. The second
concept was patient engagement in medication management, of which four themes
emerged: informing patients, patient engagement, communication amongst
health-care professionals and conflicting advice.
DISCUSSION AND CONCLUSION: This study provides an important insight into
patients' experiences and perceptions of MRPs following discharge from hospital.
Future direction for practice and research should look into implementing
patient-centred care at the time of hospital discharge to ensure the provision of
clear and consistent information, and developing ways to support and empower
patients to ensure a smooth transition post-discharge from hospital.
© 2017 The Authors Health Expectations Published by John Wiley & Sons Ltd.
DOI: 10.1111/hex.12556
PMCID: PMC5600251
PMID: 28306185 [Indexed for MEDLINE]
Murali KM(1), Mullan J(2), Chen JH(3), Roodenrys S(4), Lonergan M(3).
Author information:
(1)Department of Nephrology, Wollongong Hospital, Wollongong, NSW, 2500,
Australia. karumathil.murali@health.nsw.gov.au.
(2)Graduate School of Medicine, University of Wollongong, Wollongong, NSW,
Australia.
(3)Department of Nephrology, Wollongong Hospital, Wollongong, NSW, 2500,
Australia.
(4)School of Psychology, University of Wollongong, Wollongong, NSW, Australia.
DOI: 10.1186/s12882-017-0449-1
PMCID: PMC5282698
PMID: 28143438 [Indexed for MEDLINE]
Diabetes self-care in primary health facilities in India - challenges and the way
forward.
Author information:
(1)Department of Community Medicine, Maulana Azad Medical College, New Delhi
110002, India. saurav.basu.mph@gmail.com.
(2)Department of Community Medicine, Maulana Azad Medical College, New Delhi
110002, India.
India has approximately 73 million people living with diabetes and another 37
million with prediabetes while nearly 47% of the diabetes cases are undiagnosed.
The high burden of poor glycemic control and early onset of complications with
associated economic costs indicates a high prevalence of poor self-management
practices. It is well-established that achieving patient-centered primary care
consistent with a chronic care model ensures optimum diabetes self-management
support and improves long-term clinical and health outcomes in diabetes patients.
The public sector primary care system in India provides services free of cost to
beneficiaries but lacks patient-centered care that undermines diabetes
self-management education and support. Furthermore, factors like poor patient
knowledge of diabetes, suboptimal medication adherence, persistent clinical
inertia, lack of data for monitoring and evaluation through clinical audit
worsens the standards of diabetes care in primary care settings of India. There
is a need for government initiatives to be directed towards the provision of
comprehensive outpatient care that is inclusive of uninterrupted supply of drugs,
provision of essential laboratory investigators, training and availability of
qualified diabetes educators and availability of specialist support when
required. Furthermore, the integration of depression screening and smoking
cessation services at the primary care level is warranted.
DOI: 10.4239/wjd.v10.i6.341
PMCID: PMC6571487
PMID: 31231457
Collaborators: Bell SP, Cawthon C, Couey C, Donato KM, Fuentes V, Harrell FE,
Hendrickson B, Leak C, Lewis D, Meyers AG, Rothman RL, Schnelle JF, Vasilevskis
EE, Wright KH.
Author information:
(1)a Section of Hospital Medicine, Division of General Internal Medicine and
Public Health, Department of Medicine , Vanderbilt University Medical Center ,
Nashville , Tennessee , USA.
(2)b Center for Clinical Quality and Implementation Research , Vanderbilt
University Medical Center , Nashville , Tennessee , USA.
(3)c Center for Health Services Research , Vanderbilt University Medical Center ,
Nashville , Tennessee , USA.
(4)d Department of Biostatistics , Vanderbilt University Medical Center ,
Nashville , Tennessee , USA.
(5)e Department of Veterans Affairs , Tennessee Valley Healthcare System
Geriatric Research Education and Clinical Center , Nashville , Tennessee , USA.
(6)f Department of Emergency Medicine , Vanderbilt University Medical Center ,
Nashville , Tennessee , USA.
(7)g Department of Biomedical Informatics , Vanderbilt University Medical Center
, Nashville , Tennessee , USA.
(8)h School of Nursing , Vanderbilt University Medical Center , Nashville ,
Tennessee , USA.
DOI: 10.1080/10810730.2015.1080331
PMCID: PMC4705844
PMID: 26513029 [Indexed for MEDLINE]
1617. Ann Med Health Sci Res. 2015 Jan-Feb;5(1):59-64. doi: 10.4103/2141-
9248.149791.
Rajasekharan D(1), Kulkarni V(1), Unnikrishnan B(1), Kumar N(1), Holla R(1),
Thapar R(1).
Author information:
(1)Department of Community Medicine, Kasturba Medical College (Affiliated to
Manipal University), Mangalore, Karnataka, India.
DOI: 10.4103/2141-9248.149791
PMCID: PMC4350065
PMID: 25745579
Author information:
(1)Center for Social and Affective Neuroscience, IKE, Linköping University;
eric.augier@liu.se.
(2)Laboratory of Clinical and Translational Studies, National Institute on
Alcohol Abuse and Alcoholism, National Institutes of Health.
(3)Center for Social and Affective Neuroscience, IKE, Linköping University.
DOI: 10.3791/53305
PMCID: PMC5352301
PMID: 28190044 [Indexed for MEDLINE]
Author information:
(1)Nursing Department, Faculty of Health Science, University of Muhammadiyah
Malang, Indonesia.
(2)Faculty of Nursing, H.R.H Princess Chulabhorn's College of Medical Science,
Thailand.
(3)Boromarajonani College of Nursing Chakriraj, Thailand.
DOI: 10.1016/j.ijnss.2017.06.010
PMCID: PMC6626170
PMID: 31406750
A Digital Ecosystem of Diabetes Data and Technology: Services, Systems, and Tools
Enabled by Wearables, Sensors, and Apps.
Heintzman ND(1).
Author information:
(1)Dexcom Inc, San Diego, CA, USA nheintzman@dexcom.com.
DOI: 10.1177/1932296815622453
PMCID: PMC4738231
PMID: 26685994 [Indexed for MEDLINE]
1621. Glob J Health Sci. 2016 Oct 1;8(10):55593. doi: 10.5539/gjhs.v8n10p57.
Author information:
(1)Department of Nursing, College of Nursing, Yonsei University, Seoul, Korea.
dream0211@hanmail.net.
DOI: 10.5539/gjhs.v8n10p57
PMID: 27302444
A framework for measuring self-management effectiveness and health care use among
pediatric asthma patients and families.
Rangachari P(1).
Author information:
(1)College of Allied Health Sciences, Augusta University, Augusta, GA, USA.
DOI: 10.2147/JAA.S133481
PMCID: PMC5396924
PMID: 28442924
1623. Psychol Res Behav Manag. 2016 Jan 21;9:7-20. doi: 10.2147/PRBM.S36238.
eCollection 2016.
Author information:
(1)Institute of Diabetes for Older People, University of Bedfordshire, Luton,
Bedfordshire, UK.
DOI: 10.2147/PRBM.S36238
PMCID: PMC4727517
PMID: 26855601
Author information:
(1)Population Policy and Practice Programme, UCL Institute of Child Health,
University College London, 30 Guilford Street, London WC1N 1EH, UK.
heather.bailey@ucl.ac.uk.
DOI: 10.1186/1471-2458-14-993
PMCID: PMC4180980
PMID: 25248469 [Indexed for MEDLINE]
Punekar YS(1), Sharma S(2), Pahwa A(2), Takyar J(2), Naya I(3), Jones PW(4).
Author information:
(1)Health Outcomes, ViiV Healthcare, 980 Great West Road, Brentford, Middlesex,
TW8 9GS, UK. yogesh.q.punekar@gsk.com.
(2)PAREXEL® Access Consulting, PAREXEL® International, Chandigarh, India.
(3)Respiratory Medical, GSK, Brentford, Middlesex, UK.
(4)Institute of Infection and Immunity, St George's, University of London,
London, UK.
DOI: 10.1186/s12931-017-0566-1
PMCID: PMC5422957
PMID: 28482883 [Indexed for MEDLINE]
1626. Drug Healthc Patient Saf. 2014 Oct 24;6:155-65. doi: 10.2147/DHPS.S68786.
eCollection 2014.
Author information:
(1)Unit of Pharmacology and Therapeutics, School of Pharmacy, Muhimbili
University of Health and Allied Sciences, Dar es Salaam, Tanzania.
DOI: 10.2147/DHPS.S68786
PMCID: PMC4216043
PMID: 25368533
Chou FY(1), Kuang LY(2), Lee J(3), Yoo GJ(4), Fung LC(5).
Author information:
(1)School of Nursing, San Francisco State University, San Francisco, CA, USA.
(2)Department of Nursing, Chinese Hospital, San Francisco, CA, USA.
(3)Physical Therapy, San Francisco State University, San Francisco, CA, USA.
(4)Asian American Studies, San Francisco State University, San Francisco, CA,
USA.
(5)Health Education, Chinatown Public Health Center, San Francisco, CA, USA.
OBJECTIVE: This paper summarizes the barriers and challenges in cancer care
reported from a validation project of a self-management intervention handbook
from Chinese-American cancer patients with limited English proficiency (LEP).
METHODS: Seven health-care providers (HCPs) and 16 Chinese-American cancer
survivors with LEP were invited to validate a self-management intervention
handbook through networking sampling method. Bilingual versions were developed
and validated using the repeated translation process. Online and paper-based
survey and interview were conducted to collect information on the perception of
barriers and experiences on cancer care. Data were analyzed by the content
analysis method.
RESULTS: The HCPs reported a bilingual self-management handbook which is useful
and feasible for patient self-management. The challenges in giving cancer care to
LEP patients included: patients do not engage in discussion, different cultural
health beliefs, unable to speak to patients in their primary language, and
patients are less likely to discuss emotional and social challenges during
treatments. The common barriers and experiences during cancer care included:
limited understanding about treatment/medication and side effects, language
barriers such as unable to communicate to make the decision, unable to understand
information related to resources and do not know what questions to ask, and do
not know what to expect during their cancer treatment.
CONCLUSIONS: The current findings highlight the need of cancer self-management
support for culturally diverse LEP cancer patients. Further research can include
applying the supportive intervention to all LEP cancer patients.
DOI: 10.4103/2347-5625.189815
PMCID: PMC5123524
PMID: 27981169
1628. NPJ Prim Care Respir Med. 2017 Apr 24;27(1):29. doi: 10.1038/s41533-017-0031-
0.
Practice makes perfect: self-reported adherence a positive marker of inhaler
technique maintenance.
Azzi E(1), Srour P(2), Armour C(2)(3), Rand C(4), Bosnic-Anticevich S(2)(3).
Author information:
(1)Woolcock Institute of Medical Research, University Of Sydney, Sydney, NSW,
Australia. elizabeth.azzi@sydney.edu.au.
(2)Woolcock Institute of Medical Research, University Of Sydney, Sydney, NSW,
Australia.
(3)Sydney Local Health District, Sydney, NSW, Australia.
(4)Department of Medicine, John Hopkins University, Baltimore, MD, USA.
Poor inhaler technique and non-adherence to treatment are major problems in the
management of asthma. Patients can be taught how to achieve good inhaler
technique, however maintenance remains problematic, with 50% of patients unable
to demonstrate correct technique. The aim of this study was to determine the
clinical, patient-related and/or device-related factors that predict inhaler
technique maintenance. Data from a quality-controlled longitudinal community care
dataset was utilized. 238 patients using preventer medications where included.
Data consisted of patient demographics, clinical data, medication-related factors
and patient-reported outcomes. Mixed effects logistic regression was used to
identify predictors of inhaler technique maintenance at 1 month. The variables
found to be independently associated with inhaler technique maintenance using
logistic regression (Χ 2 (3,n = 238) = 33.24, p < 0.000) were inhaler technique
at Visit 1 (OR 7.1), device type (metered dose inhaler and dry powder inhalers)
(OR 2.2) and self-reported adherent behavior in the prior 7 days (OR 1.3). This
research is the first to unequivocally establish a predictive relationship
between inhaler technique maintenance and actual patient adherence, reinforcing
the notion that inhaler technique maintenance is more than just a physical skill.
Inhaler technique maintenance has an underlying behavioral component, which
future studies need to investigate.ASTHMA: BEHAVIORAL ELEMENT TO CORRECT
LONG-TERM INHALER TECHNIQUES: Patients who consciously make an effort to perfect
asthma inhaler technique will maintain their skills long-term. Elizabeth Azzi at
the University of Sydney, Australia, and co-workers further add evidence that
there is a strong behavioral component to patients retaining correct inhaler
technique over time. Poor inhaler technique can limit asthma control, affecting
quality of life and increasing the chances of severe exacerbations. Azzi's team
followed 238 patients to determine the key predictors of inhaler technique
maintenance from factors including age, asthma knowledge and perceived future
risks. Correct inhaler technique at initial assessment was the strongest
predictor of long-term success, but this was strengthened further when patients
reported good adherence to their own medication regimen. This suggests that
maintaining correct inhaler technique is more than just a physical skill. Careful
guidance towards this 'practice makes perfect' approach may improve patients'
long-term technique maintenance.
DOI: 10.1038/s41533-017-0031-0
PMCID: PMC5435088
PMID: 28439076 [Indexed for MEDLINE]
BACKGROUND: Both depression and the metabolic syndrome (MetS) are two major
public health issues. The aim of this study was to examine associations between
depressive symptoms, the use of antidepressant medications, and the prevalence of
MetS.
METHODS: Cross-sectional analyses were undertaken on 970 participants from the
Maine-Syracuse Study. Depressive symptoms were measured using two self-reported
depression scales, the Center for Epidemiological Studies Depression Scale
(CES-D), and the Zung self-rating depression scale. Antidepressant medication use
was also self-reported. MetS was defined according to the recent harmonized
criteria.
RESULTS: The risk of MetS were approximately 79 and 86 % higher for those in the
highest quartile for the CESD and the Zung (CES-D: OR = 1.79, p = 0.003; Zung:
OR = 1.71, p = 0.006), compared to those in the lowest quartile. With adjustment
for socio-demographic variables, lifestyle factors and C-reactive protein (CRP),
risk was attenuated, but remained statistically significant for the CES-D. In
those who reported using antidepressant medication, the odds of having MetS were
over 2-fold higher (OR = 2.22, p < 0.001, fully adjusted model), compared to
those who did not use antidepressants. Both measures of depressed mood were also
associated with low high density-lipoprotein (HDL) cholesterol levels.
Antidepressant use was associated with elevated fasting plasma glucose
concentrations, hypertension, and low HDL-cholesterol.
CONCLUSION: Depressive symptoms and the use of antidepressant medications are
associated with the prevalence of MetS, and with some of the individual
components of the syndrome.
DOI: 10.1186/s12889-016-3170-2
PMCID: PMC4902917
PMID: 27287001 [Indexed for MEDLINE]
Author information:
(1)Stanger Hospital and Discipline of Public Health Medicine, University of
KwaZulu Natal, Durban, South Africa.
(2)Discipline of Public Health Medicine; University of KwaZulu Natal, Durban,
South Africa.
DOI: 10.11604/pamj.2019.33.4.16963
PMCID: PMC6607454
PMID: 31303949 [Indexed for MEDLINE]
Govender M(1), Bowen RC(2), German ML(2), Bulaj G(3), Bruggers CS(1)(2)(4)(5).
Author information:
(1)1 Division of Hematology-Oncology, University of Utah School of Medicine ,
Salt Lake City, Utah.
(2)2 Department of Pediatrics, University of Utah School of Medicine , Salt Lake
City, Utah.
(3)3 Department of Medicinal Chemistry, College of Pharmacy, University of Utah ,
Salt Lake City, Utah.
(4)4 Huntsman Cancer Institute, University of Utah School of Medicine , Salt Lake
City, Utah.
(5)5 Primary Children's Hospital , Salt Lake City, Utah.
Pediatric oncology patients often experience fatigue and physical and mental
deconditioning during and following chemotherapy treatments, contributing to
diminished quality of life. Patient empowerment is a core principle of
patient-centered care and reflects one's ability to positively affect his or her
own health behavior and health status. Empowerment interventions may enhance
patients' internal locus of control, resilience, coping skills, and
self-management of symptoms related to disease and therapy. Clinical and
technological advancements in therapeutic videogames and mobile medical
applications (mobile health) can facilitate delivery of the empowerment
interventions for medical purposes. This review summarizes clinical strategies
for empowering pediatric cancer patients, as well as their relationship with
developing a "fighting spirit" in physical and mental health. To better
understand physiological aspects of empowerment and to elucidate videogame-based
intervention strategies, brain neuronal circuits and neurotransmitters during
stress, fear, and resilience are also discussed. Neuroimaging studies point to
the role of the reward system pathways in resilience and empowerment in patients.
Taken together, videogames and mobile health applications open translational
research opportunities to develop and deliver empowerment interventions to
pediatric cancer patients and also to those with other chronic diseases.
DOI: 10.1089/g4h.2015.0014
PMCID: PMC4545566
PMID: 26287927 [Indexed for MEDLINE]
Author information:
(1)From the aEpidemiology Branch, Division of Intramural Population Health
Research, Eunice Kennedy Shriver National Institute of Child Health and Human
Development, National Institutes of Health, Bethesda, MD; bDivision of Research,
Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA; cOffice of the
Director, Division of Intramural Population Health Research, Eunice Kennedy
Shriver National Institute of Child Health and Human Development, National
Institutes of Health, Bethesda, MD; and dBiostatistics and Bioinformatics Branch,
Division of Intramural Population Health Research, Eunice Kennedy Shriver
National Institute of Child Health and Human Development, National Institutes of
Health, Bethesda, MD.
1633. J Couns Psychol. 2016 Jul;63(4):452-9. doi: 10.1037/cou0000142. Epub 2016 Feb
11.
Chui H(1), Zilcha-Mano S(2), Dinger U(3), Barrett MS(4), Barber JP(1).
Author information:
(1)Derner Institute of Advanced Psychological Studies.
(2)Department of Psychology, University of Haifa.
(3)Department for General Internal Medicine and Psychosomatics, University of
Heidelberg.
(4)Department of Psychiatry, University of Pennsylvania.
Dependency and self-criticism are vulnerability factors for depression. How these
personality factors change with treatment for depression and how they relate to
symptom change across different types of treatment require further research. In
addition, cultural differences that interact with the
dependency/self-criticism-depression relation remain underinvestigated. We
randomly assigned 149 adults with major depression to receive active medication
(MED; n = 50), supportive-expressive therapy (SET; n = 49), or placebo pill (PBO;
n = 50). Participants completed the Depressive Experiences Questionnaire (DEQ;
Blatt, D'Afflitti, & Quinlan, 1976) before and after treatment and completed the
Hamilton Rating Scale for Depression (Hamilton, 1967) throughout the course of
treatment. Self-criticism as measured on the DEQ decreased with treatment
similarly across conditions. DEQ Dependency decreased in MED but remained
unchanged in SET and PBO. Higher initial dependency, but not higher initial
self-criticism, predicted poor treatment response across conditions. Greater
reduction in self-criticism was associated with greater reduction in depressive
symptoms, but the effect was weaker for racial minorities (vs. White). Increase
in connectedness, an adaptive form of dependency, was associated with symptom
improvement in SET but not MED. Hence, different pathways of change seem to be
implicated in the treatment of depression depending on culture and type of
intervention. Implications for future research are discussed. (PsycINFO Database
Record
DOI: 10.1037/cou0000142
PMCID: PMC4935564
PMID: 26866638 [Indexed for MEDLINE]
Psihogios AM(1)(2), Murray C(1), Zebracki K(3)(4), Acevedo L(1), Holmbeck GN(1).
Author information:
(1)Loyola University Chicago.
(2)The Children's Hospital of Philadelphia.
(3)Shriners Hospitals for Children.
(4)Northwestern University Feinberg School of Medicine.
© The Author 2016. Published by Oxford University Press on behalf of the Society
of Pediatric Psychology. All rights reserved. For permissions, please e-mail:
journals.permissions@oup.com
DOI: 10.1093/jpepsy/jsw092
PMCID: PMC6251535
PMID: 27831479 [Indexed for MEDLINE]
Improved Blood Pressure Control Using an Interactive Mobile Phone Support System.
Author information:
(1)Institute of Health and Care Science, Sahlgrenska Academy, University of
Gothenburg, Gothenburg, Sweden.
(2)University of Gothenburg Centre for Person-Centred Care (GPCC), Sahlgrenska
Academy, University of Gothenburg, Gothenburg, Sweden.
(3)Department of Food, Nutrition and Sport Science, Department of Psychology,
University of Gothenburg, Gothenburg, Sweden.
This explorative, longitudinal study evaluated the effect of the daily use of a
mobile phone-based self-management support system for hypertension in reducing
blood pressure (BP) among 50 primary care patients with hypertension over 8
weeks. The self-management system comprises modules for (1) self-reports of BP,
pulse, lifestyle, symptoms, and well-being; (2) delivery of reminders and
encouragements; and (3) graphical feedback of self-reports. Daily use of the
support system significantly reduced BP (systolic BP -7 mm Hg, diastolic BP -4.9
mm Hg) between baseline and week 8, with daily improvements leveling off as the
study progressed. Three homogenous subsets of patients were identified who,
despite different initial BP levels, showed similar decreases in BP during the
study, indicating that patients benefited irrespective of baseline BP. In showing
significant reductions in BP, our results suggest that the self-management
support system may be a useful tool in clinical practice to help patients
self-manage their hypertension.
© 2015 The Authors. The Journal of Clinical Hypertension Published by Wiley
Periodicals, Inc.
DOI: 10.1111/jch.12682
PMCID: PMC5057328
PMID: 26456490 [Indexed for MEDLINE]
Smith LE(1), D'Antoni D(2), Jain V(1), Pearce JM(3), Weinman J(2), Rubin GJ(4).
Author information:
(1)Department of Psychological Medicine, King's College London, London, UK.
(2)Institute of Pharmaceutical Science, King's College London, London, UK.
(3)Department of War Studies, King's College London, London, UK.
(4)Department of Psychological Medicine, King's College London, London, UK.
Gideon.rubin@kcl.ac.uk.
The aim of this review was to identify factors predicting actual or intended
adherence to antivirals as treatment or prophylaxis for influenza. Literature
from inception to March 2015 was systematically reviewed to find studies
reporting predictors of adherence to antivirals and self-reported reasons for
non-adherence to antivirals. Twenty-six studies were included in the review;
twenty identified through the literature search and six through other means. Of
these studies, 18 assessed predictors of actual adherence to antivirals, whereas
eight assessed predictors of intended adherence. The most commonly found
predictor of, and self-reported reason for, non-adherence was the occurrence of
side effects. Other predictors include perceptions surrounding self-efficacy,
response efficacy and perceived personal consequences as well as social
influences of others' experiences of taking antivirals. Predictors identified in
this review can be used to help inform communications to increase adherence to
antivirals in both seasonal and pandemic influenza.
© 2016 The Authors. Influenza and Other Respiratory Viruses Published by John
Wiley & Sons Ltd.
DOI: 10.1111/irv.12406
PMCID: PMC5059947
PMID: 27397480 [Indexed for MEDLINE]
Author information:
(1)Roee Holtzer, Ph.D. Ferkauf Graduate School of Psychology and Department of
Neurology, Albert Einstein College of Medicine, Yeshiva University, NY, USA.
Phone: 718 430-3962; Fax: 718 430-3960; email: roee.holtzer@einstein.yu.edu.
OBJECTIVES: Functional losses are common in healthy and cognitively impaired
older adults. However, subtle declines in instrumental activities of daily living
(IADLs) are not always detected in self-reports. Performance IADL measurements
are financially and time burdensome, restricting their use in varied settings. To
address these limitations, we developed the Brief Everyday Activities Measure
(BEAM), a short (< 5 minutes) objective IADL measure that assesses medication and
finance management.
DESIGN AND PARTICIPANTS: The BEAM was administered to 209 cognitively
non-demented community-dwellers (ages 65 - 95 years).
MEASUREMENTS: Participants completed standardized motor, neuropsychological,
psychological, and self-report functional assessments.
RESULTS: BEAM completion time ranged from 54.16 to 259.31 seconds. Interclass
correlations (ICC) for total BEAM completion time was moderate (0.65, 95% CI [.43
-.78]). Accuracy for total BEAM performance was in the low-moderate range (Kappa
= 0.38, p < .001, 95% CI [.18 -.54]). As predicted, lower accuracy and longer
time to complete the BEAM were both associated with worse executive functions,
attention, and processing speed.
CONCLUSIONS: Medication and finance management can be efficiently assessed within
five minutes. The BEAM may be a valuable screening tool to evaluate these
functional abilities.
DOI: 10.1007/s12603-015-0545-5
PMCID: PMC5331926
PMID: 26482695 [Indexed for MEDLINE]
Author information:
(1)Psychiatric Epidemiology and Social Issues Unit, Centre for Research on
Ageing, Health & Wellbeing, Research School for Population Health, Australian
National University, Canberra, Australia.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://group.bmj.com/group/rights-licensing/permissions.
DOI: 10.1136/bmjopen-2015-008975
PMCID: PMC4606421
PMID: 26443661 [Indexed for MEDLINE]
Modafinil decreases cocaine choice in human cocaine smokers only when the
response requirement and the alternative reinforcer magnitude are large.
Author information:
(1)Division on Substance Abuse, New York State Psychiatric Institute and
Department of Psychiatry, Columbia University Medical Center, 1051 Riverside
Drive, Unit 120, New York, NY 10032, USA. Electronic address:
rwf2@cumc.columbia.edu.
(2)Division on Substance Abuse, New York State Psychiatric Institute and
Department of Psychiatry, Columbia University Medical Center, 1051 Riverside
Drive, Unit 120, New York, NY 10032, USA.
This study examined how response effort (pressing a keyboard button) for cocaine
and the value of an alternative reinforcer (opportunity to play a game of chance
for money) combined with 'free' cocaine (with no response effort) affected
cocaine choice when participants were maintained on modafinil or placebo.
Nontreatment-seeking current cocaine smokers were enrolled in a
placebo-controlled, double-blind, within-subject study comprising both inpatient
and outpatient phases. Participants were maintained on placebo capsules (0mg/day)
during one inpatient phase and modafinil (300mg/day) capsules during another
inpatient phase in counter-balanced order. A minimum of 8 medication-free days
separated the two 15-day inpatient phases to allow for medication clearance.
Under each medication condition participants had the opportunity to
self-administer smoked cocaine (25mg) when the response effort for cocaine was
low (500responses/dose) and had a low value alternative (2 game plays for money)
or when the response effort for cocaine was large (2500responses/dose) and had a
more valuable alternative (4 game plays for money). Under both conditions,
participants received one free dose of cocaine (0, 12, 25 or 50mg) prior to
making their first choice of the session. Fifteen individuals began the study and
7 completed it. Participants chose fewer cocaine doses when the response effort
for cocaine and the alternative value was high (4.4±0.19) compared to when the
response effort for cocaine and the alternative value was low (5.3±0.14).
Providing individuals a free "priming" dose of cocaine prior to making their
cocaine choice did not alter cocaine taking. Modafinil decreased cocaine choice
only when the response effort for cocaine and the alternative value was high.
These results suggest that modafinil may be most effective when combined with
therapy emphasizing the large personal costs of using cocaine.
DOI: 10.1016/j.pbb.2016.08.009
PMCID: PMC5145770
PMID: 27592732 [Indexed for MEDLINE]
Cedillo-Couvert EA(1), Ricardo AC(1), Chen J(1), Cohan J(1), Fischer MJ(1)(2)(3),
Krousel-Wood M(4), Kusek JW(5), Lederer S(1)(2)(3), Lustigova E(4), Ojo A(6),
Porter AC(1), Sharp LK(1), Sondheimer J(7), Diamantidis C(8), Wang X(9), Roy
J(9), Lash JP(1); CRIC Study Investigators.
Collaborators: Appel LJ, Feldman HI, Go AS, He J, Kusek JW, Lash JP, Rahman M,
Rao PS, Townsend RR.
Author information:
(1)Department of Medicine, University of Illinois at Chicago, Chicago, Ilinois,
USA.
(2)Department of Medicine, Jesse Brown VAMC, Chicago, Illinois, USA.
(3)Research Service, Center of Innovation for Complex Chronic Healthcare, Edward
Hines Jr., VA Hospital, Hines, Illinois, USA.
(4)Department of Medicine and Epidemiology, Tulane University, New Orleans,
Louisiana, USA; Research Division, Ochsner Health System, New Orleans, Louisiana,
USA.
(5)National Institute of Diabetes and Digestive and Kidney Diseases, National
Institutes of Health, Bethesda, Maryland, USA.
(6)Department of Medicine, University of Arizona, Phoenix, Arizona, USA.
(7)Department of Internal Medicine, Wayne State University, Detroit, Michigan,
USA.
(8)Department of Medicine, Duke University School of Medicine, Durham, North
Carolina, USA.
(9)Department of Biostatistics and Epidemiology, University of Pennsylvania,
Philadelphia, Pennsylvania, USA.
Comment in
Natl Med J India. 2018 Nov-Dec;31(6):351-353.
DOI: 10.1016/j.ekir.2018.01.007
PMCID: PMC5976857
PMID: 29854972
Practical and clinical utility of non-invasive vagus nerve stimulation (nVNS) for
the acute treatment of migraine: a post hoc analysis of the randomized,
sham-controlled, double-blind PRESTO trial.
Author information:
(1)Neuroalgology Unit, Carlo Besta Neurological Institute and Foundation, Milan,
Italy. licia.grazzi@istituto-besta.it.
(2)Department of Fondazione IRCCS Istituto Neurologico C. Besta, U.O. Neurologia
III - Cefalee e Neuroalgologia, Via Celoria 11, 20133, Milan, Italy.
licia.grazzi@istituto-besta.it.
(3)Headache Science Centre, IRCCS C. Mondino Foundation, Pavia, Italy.
(4)Department of Brain and Behavioral Sciences, University of Pavia, Pavia,
Italy.
(5)Neurophysiology and Pain Unit, University of Bari Aldo Moro, Bari, Italy.
(6)IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
(7)Department of Clinical and Molecular Medicine, Sapienza University, Rome,
Italy.
(8)Department of Neuroscience, University of Turin, Turin, Italy.
(9)Headache Centre, University Hospital of Careggi, Florence, Italy.
(10)IRCCS Neuromed, Pozzilli (IS), Italy.
(11)Neurologic Clinic, Santa Maria della Misericordia Hospital, Perugia, Italy.
(12)electroCore, Inc, Basking Ridge, NJ, USA.
(13)Headache and Pain Unit, IRCCS San Raffaele Pisana, Rome, Italy.
Erratum in
J Headache Pain. 2019 Jan 7;20(1):1.
DOI: 10.1186/s10194-018-0928-1
PMID: 30340460 [Indexed for MEDLINE]
Feriato KT(1), Gusmão JL(1), Silva A(1), Santos CAD(2), Pereira RSF(3), Amendola
F(1).
Author information:
(1)Universidade Guarulhos. Guarulhos, São Paulo, Brazil.
(2)Hospital Municipal Dr. José de Carvalho Florence, Occupational Medicine. São
José dos Campos, São Paulo, Brazil.
(3)Centro Universitário AGES, Department of Nursing. Paripiranga, Bahia, Brazil.
DOI: 10.1590/0034-7167-2016-0469
PMID: 30156672 [Indexed for MEDLINE]
1643. AIDS Res Treat. 2016;2016:2607249. doi: 10.1155/2016/2607249. Epub 2016 Sep
8.
Author information:
(1)School of Public Health, Department of Environmental and Occupational Heath,
Sefako Makgatho Health Sciences University, Pretoria, South Africa.
(2)School of Public Health, Department of Biostatistics, Sefako Makgatho Health
Sciences University, Pretoria, South Africa.
DOI: 10.1155/2016/2607249
PMCID: PMC5031873
PMID: 27672451
Author information:
(1)Universidade Federal de São Paulo. São Paulo, São Paulo, Brazil.
(2)Universidade Federal de São Carlos. São Carlos, São Paulo, Brazil.
(3)Faculdade de Medicina de São José do Rio Preto. São José do Rio Preto, São
Paulo, Brazil.
DOI: 10.1590/0034-7167-2018-0680
PMID: 31432958
Author information:
(1)Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and
Health Sciences, University of Gondar, Gondar, Ethiopia.
(2)Department of Psychiatry, Gondar University Hospital, Gondar, Ethiopia.
(3)Pharmaceutics Unit, Department of Pharmacy, College of Medicine and Health
Sciences, Wollo University, Dessie, Ethiopia.
Erratum in
Psychiatry J. 2018 Feb 20;2018:9274278.
DOI: 10.1155/2017/5812817
PMCID: PMC5733980
PMID: 29349061
Al-Ramahi R(1).
Author information:
(1)Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah
National University, P.O. Box: 7, Nablus, Palestine. Electronic address:
rawa_ramahi@najah.edu.
Copyright © 2014 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd. All
rights reserved.
DOI: 10.1016/j.jegh.2014.05.005
PMID: 25922321 [Indexed for MEDLINE]
1647. Seizure. 2017 Feb;45:160-168. doi: 10.1016/j.seizure.2016.12.006. Epub 2016
Dec
23.
Author information:
(1)Sligo University Hospital, Sligo, Ireland. Electronic address:
geraldineorourke-meehan@hotmail.com.
(2)Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address:
Juliejordanobrien@rcsi.ie.
DOI: 10.1016/j.seizure.2016.12.006
PMID: 28063375 [Indexed for MEDLINE]
Author information:
(1)Clinic for Neurology and Palliative Medicine, Municipal Hospital Köln-Merheim,
Cologne, Germany.
(2)Institut Dr. Schauerte, Munich, Germany.
(3)Bayer Vital GmbH, Leverkusen, Germany.
DOI: 10.2196/14373
PMCID: PMC6690164
PMID: 31359863
Author information:
(1)Epidemiology and Public Health Department, Swiss Tropical and Public Health
Institute, Basel, Switzerland.
(2)Department of Public Health, Faculty of Medicine, University of Basel, Basel,
Switzerland.
(3)Health Economics Unit, School of Public Health and Family Medicine, University
of Cape Town, Cape Town, South Africa.
(4)Division of Clinical Pharmacology, Faculty of Medicine and Health Sciences,
Stellenbosch University, Cape Town, South Africa.
(5)Fundisa African Academy of Medicines Development, Cape Town, South Africa.
(6)Institute of Pharmaceutical Medicine, University of Basel, Basel, Switzerland.
(7)Epidemiology, Biostatistics and Prevention Institute, University of Zürich,
Zurich, Switzerland.
(8)Patient Centered Outcomes, Adelphi Values, Bollington, United Kingdom.
DOI: 10.3389/fphar.2017.00919
PMCID: PMC5741974
PMID: 29326591
DOI: 10.1590/1806-9282.63.03.252
PMID: 28489132 [Indexed for MEDLINE]
Author information:
(1)Clinical Epidemiology Research Center, Veterans Affairs Connecticut Healthcare
System, West Haven, Connecticut.
(2)Department of Medicine, Program on Aging, Yale School of Medicine, New Haven,
Connecticut.
(3)Department of Communication, Texas A&M University, College Station, Texas.
(4)Houston Center for Quality of Care and Utilization Studies, Baylor College of
Medicine, Houston, Texas.
(5)Program on Aging, Yale School of Medicine, New Haven, Connecticut.
(6)Center for Medical Informatics, Yale School of Medicine, New Haven,
Connecticut.
(7)Pain Research, Informatics, Multi-morbidities, and Education Center, Veterans
Affairs Connecticut Healthcare System, West Haven, Connecticut.
(8)Palo Alto Geriatric Research, Education and Clinical Center and Medical
Service, Veterans Affairs Palo Alto Health Care System, Palo Alto.
(9)Department of Medicine, Center for Primary Care and Outcomes Research,
Stanford University, Stanford, California.
© 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics
Society.
DOI: 10.1111/jgs.15042
PMCID: PMC5641237
PMID: 28804870 [Indexed for MEDLINE]
Author information:
(1)Leeds General Infirmary, Great George Street, Leeds, UK.
(2)Leeds General Infirmary, Great George Street, Leeds, UK. Electronic address:
a.kanatas@doctors.org.uk.
Comment in
Br J Oral Maxillofac Surg. 2018 Apr;56(3):237-238.
DOI: 10.1016/j.bjoms.2017.06.019
PMID: 28964667 [Indexed for MEDLINE]
Author information:
(1)Medical University Innsbruck, Department of Psychiatry,Psychotherapy, and
Psychosomatics. Division of Psychiatry I, Anichstrasse 35, 6020, Innsbruck,
Austria. christian.widschwendter@i-med.ac.at.
(2)Medical University Innsbruck, Department of Psychiatry,Psychotherapy, and
Psychosomatics. Division of Psychiatry I, Anichstrasse 35, 6020, Innsbruck,
Austria.
DOI: 10.1186/s12888-018-1791-y
PMCID: PMC6022409
PMID: 29954366 [Indexed for MEDLINE]
1654. Trans R Soc Trop Med Hyg. 2016 Dec 1;110(12):696-704. doi:
10.1093/trstmh/trx003.
Markers of poor adherence among adults with HIV attending Themba Lethu HIV
Clinic, Helen Joseph Hospital, Johannesburg, South Africa.
Nnambalirwa M(1), Govathson C(2), Evans D(2), McNamara L(3), Maskew M(2), Nyasulu
P(1)(4).
Author information:
(1)School of Public Health, Faculty of Health Sciences, University of the
Witwatersrand, Johannesburg, South Africa.
(2)Health Economics and Epidemiology Research Office, Department of Internal
Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of
the Witwatersrand, Johannesburg, South Africa.
(3)Clinical HIV Research Unit, Department of Internal Medicine, School of
Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand,
Johannesburg, South Africa.
(4)Department of Public Health, School of Health Sciences, Monash University,
Johannesburg, South Africa.
DOI: 10.1093/trstmh/trx003
PMCID: PMC5914359
PMID: 28938050 [Indexed for MEDLINE]
Background: Nutrition literacy (NL) and food literacy (FL) have emerged as
distinct forms of the multifaceted concept of health literacy (HL). Despite
convincing evidence that changes in dietary behavior can improve health, the role
of nutrition in supporting self-management in patients with chronic respiratory
disease tends to be overlooked.
Objective: This study examined patient and key informant (health care
professionals, researchers, and policymakers) perspectives on nutrition in the
context of self-management practices in asthma and chronic obstructive pulmonary
disease with implications for NL and FL.
Methods: Data were collected during 16 focus groups with 93 English- and
French-speaking patients in the Canadian Provinces of British Columbia, Ontario,
and Quebec, and in-depth interviews with 45 key informants mainly from Canada.
Participants' comments, including dietary perception keywords, were extracted and
classified using NVivo software. Thematic analysis was applied.
Key Results: Patients' perspectives on nutrition reflected three broad themes:
(1) importance of nutrition knowledge in self-management, (2) applying nutrition
knowledge in self-management, and (3) challenges in applying nutrition knowledge
in self-management. Embedded within the third theme were six sub-themes:
Limitations in "accessing nutrition information," "understanding nutrition
information," "basic literacy skills," and "ability to act on nutrition
information," along with "lack of supports to act on nutrition information," and
"competing daily demands in mealtime and medication management." Although less
than 10% of key informants provided nutrition-relevant comments, their comments
reinforced patients' concerns about barriers to accessing, understanding, and
using nutrition information in self-management.
Conclusions: Our findings suggest that more attention be directed to nutrition in
the self-management of chronic respiratory disease and warrant further research
on the roles of NL and FL in this health practice context. Such research could
also contribute to the broader agenda of understanding NL and FL and applying
them as subconcepts of HL in chronic disease self-management interventions. [
HLRP: Health Literacy Research and Practice. 2018;2(3):e166-e174.].
Plain Language Summary: Growing evidence supporting the role of diet in chronic
disease calls for more attention to nutrition literacy. This study explored
patient and key informant viewpoints on engaging with nutrition information in
self-management of chronic lung disease. Findings suggest patients encounter many
challenges in accessing, understanding, and acting on relevant nutrition
information.
DOI: 10.3928/24748307-20180803-01
PMCID: PMC6607835
PMID: 31294292
Boulet LP(1), Boulay MÈ(2), Gauthier G(3), Battisti L(4), Chabot V(3), Beauchesne
MF(5), Villeneuve D(3), Côté P(3).
Author information:
(1)Institut universitaire de cardiologie et de pneumologie de Québec, Université
Laval, Québec, QC, Canada. Electronic address: lpboulet@med.ulaval.ca.
(2)Institut universitaire de cardiologie et de pneumologie de Québec, Université
Laval, Québec, QC, Canada.
(3)Réseau québécois de l'asthme et de la MPOC (RQAM), Québec, QC, Canada.
(4)Réseau québécois de l'asthme et de la MPOC (RQAM), Québec, QC, Canada; Hôpital
St-François d'Assise, Québec, QC, Canada.
(5)Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC, Canada.
DOI: 10.1016/j.rmed.2015.05.004
PMID: 26162708 [Indexed for MEDLINE]
Author information:
(1)HESAV, The University of Health Sciences (HES-SO), Av. de Beaumont 21, 1011,
Lausanne, Switzerland. nancy.helou@hesav.ch.
(2)Faculty of Biology and Medicine, University Institute of Higher Education and
Research in Healthcare (IUFRS), University of Lausanne, Biopôle 2, Route de la
Corniche 10, 1010, Lausanne, Switzerland. nancy.helou@hesav.ch.
(3)Clinique de La Source, Avenue Vinet 30, 1004, Lausanne, Switzerland.
(4)Faculty of Biology and Medicine, University Institute of Higher Education and
Research in Healthcare (IUFRS), University of Lausanne, Biopôle 2, Route de la
Corniche 10, 1010, Lausanne, Switzerland.
(5)Services of Nephrology, Diabetes and Endocrinology, Department of Internal
Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon 17,
1011, Lausanne, Switzerland.
DOI: 10.1186/s12882-016-0279-6
PMCID: PMC4949754
PMID: 27430216 [Indexed for MEDLINE]
Mobile Phone Support for Diabetes Self-Care Among Diverse Adults: Protocol for a
Three-Arm Randomized Controlled Trial.
Author information:
(1)Center for Health Behavior and Health Education, Department of Medicine,
Vanderbilt University Medical Center, Nashville, TN, United States.
(2)Center for Diabetes Translation Research, Department of Medicine, Vanderbilt
University Medical Center, Nashville, TN, United States.
(3)School of Nursing, Vanderbilt University, Nashville, TN, United States.
(4)Center for Effective Health Communication, Department of Medicine, Vanderbilt
University Medical Center, Nashville, TN, United States.
(5)Center for Clinical Quality and Implementation Research, Department of
Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
(6)Department of Biostatistics, Vanderbilt University Medical Center, Nashville,
TN, United States.
(7)Department of Pharmacy, College of Pharmacy and Health Sciences, Lipscomb
University, Nashville, TN, United States.
BACKGROUND: Nonadherence to self-care is common among patients with type 2
diabetes (T2D) and often leads to severe complications. Moreover, patients with
T2D who have low socioeconomic status and are racial/ethnic minorities
disproportionately experience barriers to adherence and poor outcomes. Basic
phone technology (text messages and phone calls) provides a practical medium for
delivering content to address patients' barriers to adherence; however, trials
are needed to explore long-term and sustainable effects of mobile phone
interventions among diverse patients.
OBJECTIVE: The aim of this study is to evaluate the effects of mobile phone-based
diabetes support interventions on self-care and hemoglobin A1c (HbA1c) among
adults with T2D using a 3-arm, 15-month randomized controlled trial with a Type 1
hybrid effectiveness-implementation approach. The intervention arms are (1) Rapid
Encouragement/Education And Communications for Health (REACH) and (2) REACH +
Family-focused Add-on for Motivating Self-care (FAMS).
METHODS: We recruited primary care patients with T2D (N=512) from Federally
Qualified Health Centers and an academic medical center, prioritizing recruitment
of publicly insured and minority patients from the latter. Eligible patients were
prescribed daily diabetes medication and owned a cell phone with text messaging
capability. We excluded patients whose most recent HbA1c result within 12 months
was <6.8% to support detection of intervention effects on HbA1c. Participants
were randomly assigned to REACH only, REACH + FAMS, or the control condition.
REACH provides text messages tailored to address patient-specific barriers to
medication adherence based on the Information-Motivation-Behavioral skills model,
whereas FAMS provides monthly phone coaching with related text message content
focused on family and friend barriers to diet and exercise adherence. We collect
HbA1c and self-reported survey data at baseline and at 3, 6, and 12 months, and
again at 15 months to assess sustained changes. We will use generalized
estimating equation models to test the effects of REACH (either intervention arm)
on HbA1c relative to the control group, the potential additive effects of FAMS,
and effects of either intervention on adherence to self-care behaviors and
diabetes self-efficacy.
RESULTS: The trial is ongoing; recruitment closed December 2017. We plan to
perform analyses on 6-month outcomes for FAMS in July 2018, and project to have
15-month data for REACH analyses in April 2019.
CONCLUSIONS: Our study will be one of the first to evaluate a long-term,
theory-based text messaging intervention to promote self-care adherence among
racially/ethnically and socioeconomically diverse adults with T2D. Moreover, our
study will assess the feasibility of a family-focused intervention delivered via
mobile phones and compare the effects of text messaging alone versus text
messaging plus phone coaching. Findings will advance our understanding of how
interventions delivered by phone can benefit diverse patients with chronic
conditions.
TRIAL REGISTRATION: ClinicalTrials.gov NCT02409329;
https://clinicaltrials.gov/ct2/show/NCT02409329 (Archived by WebCite at
http://www.webcitation.org/6yHkg9SSl); NCT02481596;
https://clinicaltrials.gov/ct2/show/NCT02481596 (Archived by WebCite at
http://www.webcitation.org/6yHkj9XD4).
©Lyndsay A Nelson, Kenneth A Wallston, Sunil Kripalani, Robert A Greevy Jr, Tom A
Elasy, Erin M Bergner, Chad K Gentry, Lindsay S Mayberry. Originally published in
JMIR Research Protocols (http://www.researchprotocols.org), 10.04.2018.
DOI: 10.2196/resprot.9443
PMCID: PMC5915673
PMID: 29636319
Rajati F(1), Sadeghi M(2), Feizi A(3), Sharifirad G(4), Hasandokht T(5),
Mostafavi F(6).
Author information:
(1)Assistant Professor, Department of Public Health, School of of Health,
Kermanshah University of Medical Sciences, Kermanshah, Iran.
(2)Associate Professor, Cardiac Rehabilitation Research Center, Isfahan
Cardiovascular Research Institute, Isfahan University of Medical Sciences,
Isfahan, Iran.
(3)Associate Professor, Department of Biostatistic, School of Public Health,
Isfahan University of Medical Sciences, Isfahan, Iran.
(4)Professor, Department of Public Health, School of Health, Qom University of
Medical Sciences, Qom, Iran.
(5)Department of Community Medicine, School of Medicine, Guilan University of
Medical Sciences, Rasht, Iran.
(6)Assistant Professor, Department of Health Education and Promotion, School of
Health, Isfahan University of Medical Sciences, Isfahan, Iran.
PMCID: PMC4354085
PMID: 25815022
Erratum for
BMC Nurs. 2016 Feb 08;15:9.
DOI: 10.1186/s12912-016-0180-4
PMCID: PMC5078912
PMID: 27799848
Sage A(1), Roberts C(1), Geryk L(1), Sleath B(1), Tate D(2)(3), Carpenter D(1).
Author information:
(1)Division of Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy,
University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
(2)Department of Nutrition, Gillings School of Global Public Health, University
of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
(3)Department of Health Behavior, Gillings School of Global Public Health,
University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
©Adam Sage, Courtney Roberts, Lorie Geryk, Betsy Sleath, Deborah Tate, Delesha
Carpenter. Originally published in JMIR Human Factors
(http://humanfactors.jmir.org), 01.02.2017.
DOI: 10.2196/humanfactors.7133
PMCID: PMC5311420
PMID: 28148471
Author information:
(1)Department of Preventive and Social Medicine, JIPMER, Puducherry, India.
DOI: 10.4103/ijcm.IJCM_192_18
PMCID: PMC6625270
PMID: 31333286
Liu CY(1), Du JZ(1), Rao CF(2), Zhang H(2), Liu HN(2), Zhao Y(1), Yang LM(3), Li
X(1), Li J(2), Wang J(4), Wang HS(5), Liu ZG(6), Cheng ZY(7), Zheng Z(2).
Author information:
(1)National Clinical Research Center of Cardiovascular Diseases, State Key
Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for
Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union
Medical College, Beijing 100073, China.
(2)National Clinical Research Center of Cardiovascular Diseases, State Key
Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for
Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union
Medical College; Department of Cardiovascular Surgery, Fuwai Hospital, National
Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and
Peking Union Medical College, Beijing 100073, China.
(3)Department of Cardiovascular Surgery, Fuwai Hospital, National Center for
Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union
Medical College, Beijing 100073, China.
(4)Department of Thoracic and Cardiovascular Surgery, The First Affiliated
Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
(5)Department of Cardiovascular Surgery, General Hospital of Shenyang Military
Region, Shenyang, Liaoning 110016, China.
(6)Department of Cardiovascular Surgery, TEDA International Cardiovascular
Hospital, Peking Union Medical College and Chinese Academy of Medical Science,
Tianjin 300457, China.
(7)Department of Cardiovascular Surgery, Henan Provincial People's Hospital,
Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan 450003, China.
Publisher: 冠脉搭桥质量改善研究:患者二级预防用药依从性研究(MISSION-2)摘要背景:
冠脉搭桥术后的二级预防药物治疗,对减少术后心血管不良事件发生至关重要。然而,既往研究显示患者二级预
防用药依从性差,并且传统提高依从性的干预手段效果有限。智能手机在
全球范围内的普及,将有望改变传统的医疗模式,低成本、高效率地提供更多诊疗机会,改善搭桥术后二级预防
水平和患者预后。但目前亟需相关的高质量临床研究提供可靠的临床应用
证据。 方法:
MISSION-2 研究是一个前瞻性、多中心、开放标签、随机对照的临床试验,计划入选 1000 例搭桥术后患者,采
用 1:1 随机分组。根据“用户中心”设计思路,我们研发了
手机应用“心健康”APP,对干预组患者从术后住院期间开始提供用药提醒,心脏术后健康宣教,心脏康复指导,
交互式个体化生活方式建议。该研究的一级终点为术后 6 个月的依据
8-MMAS 量表测量的用药依从性。二级终点包括全因死亡、心血管再住院以及死亡、心梗、中风、再次血运重建的
复合终点。 讨论:
该研究的结果,将为移动医疗技术在冠脉搭桥术后二级预防中应用的可行性和有效性提供可靠的临床证据。另外,
试验的实施经验将为在医疗资源相对不足条件下,发展移动医疗技术改
善慢病患者预后,探索患者院外自我管理新模式提供重要的借鉴。.
DOI: 10.4103/0366-6999.233767
PMCID: PMC6006808
PMID: 29873315 [Indexed for MEDLINE]
Home and Online Management and Evaluation of Blood Pressure (HOME BP) digital
intervention for self-management of uncontrolled, essential hypertension: a
protocol for the randomised controlled HOME BP trial.
Band R(1), Morton K(1), Stuart B(2), Raftery J(3), Bradbury K(1), Yao GL(3), Zhu
S(3), Little P(2), Yardley L(1), McManus RJ(4).
Author information:
(1)Academic Unit of Psychology, University of Southampton, Southampton, UK.
(2)Primary Care and Population Sciences, Faculty of Medicine, University of
Southampton, Southampton, UK.
(3)Faculty of Medicine, University of Southampton, Southampton, UK.
(4)Nuffield Department of Primary Care Health Sciences, University of Oxford,
Oxford, UK.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://www.bmj.com/company/products-services/rights-and-licensing/.
DOI: 10.1136/bmjopen-2016-012684
PMCID: PMC5129001
PMID: 27821598 [Indexed for MEDLINE]
1665. Diabet Med. 2016 Jun;33(6):844-50. doi: 10.1111/dme.12896. Epub 2015 Oct 15.
Author information:
(1)Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN,
USA.
(2)Vanderbilt Center for Diabetes Translation Research, Center for Diabetes and
Translational Research, Vanderbilt University, Nashville, TN, USA.
(3)Vanderbilt Center for Health Services Research, Nashville, TN, USA.
(4)School of Nursing, Nashville, TN, USA.
(5)Department of Biomedical Informatics and the Center for Health Behavior and
Health Education, Nashville, TN, USA.
(6)Department of Medicine, Vanderbilt University Medical Center, Nashville, TN,
USA.
(7)Department of Biostatistics, Vanderbilt University Medical Center, Nashville,
TN, USA.
(8)Department of Psychology, Vanderbilt University, Nashville, TN, USA.
DOI: 10.1111/dme.12896
PMCID: PMC4769979
PMID: 26314941 [Indexed for MEDLINE]
Holden RJ(1), Schubert CC(2), Eiland EC(3), Storrow AB(3), Miller KF(3), Collins
SP(3).
Author information:
(1)Department of BioHealth Informatics, Indiana University School of Informatics
and Computing, and the Center for Health Informatics Research and Innovation,
Indianapolis, IN. Electronic address: rjholden@iupui.edu.
(2)Department of Medical Education, Loma Linda University School of Medicine,
Loma Linda, CA.
(3)Department of Emergency Medicine, Vanderbilt University School of Medicine,
Nashville, TN.
DOI: 10.1016/j.annemergmed.2014.12.031
PMCID: PMC4478102
PMID: 25616317 [Indexed for MEDLINE]
Sasseville M(1)(2), Smith SM(3), Freyne L(3), McDowell R(3)(4), Boland F(3)(5),
Fortin M(6), Wallace E(3).
Author information:
(1)Health Sciences, Université du Québec à Chicoutimi, Chicoutimi, Quebec,
Canada.
(2)Health Science Research, Universite de Sherbrooke, Chicoutimi, Quebec, Canada.
(3)Department of General Practice, HRB Centre for Primary Care Research, Royal
College of Surgeons in Ireland (RCSI), Dublin, Ireland.
(4)Cancer Epidemiology and Health Services Research Group, Centre for Public
Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's
University, Belfast, Ireland.
(5)Division of Population Health Sciences (PHS), HRB Centre For Primary Care
Research , Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.
(6)Family Medicine, Université de Sherbrooke, Chicoutimi, Quebec, Canada.
DOI: 10.1136/bmjopen-2018-023919
PMCID: PMC6326333
PMID: 30612111
Author information:
(1)Departamento de Medicina Interna, Dermatología y Psiquiatría, Universidad de
La Laguna, Canary Islands, Spain.
(2)Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA;
Psychiatry and Neurosciences Research Group (CTS-549), Institute of
Neurosciences, University of Granada, Granada, Spain; Biomedical Research Center
in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the
Basque Country, Vitoria, Spain.
(3)Departamento de Psicología Clínica, Psicobiología y Metodología, Universidad
de La Laguna, Canary Islands, Spain.
DOI: 10.2147/PPA.S133513
PMCID: PMC5378469
PMID: 28405160
Relating Health Locus of Control to Health Care Use, Adherence, and Transition
Readiness Among Youths With Chronic Conditions, North Carolina, 2015.
Nazareth M(1), Richards J(1), Javalkar K(1), Haberman C(2), Zhong Y(1), Rak E(1),
Jain N(1), Ferris M(1), van Tilburg MA(3).
Author information:
(1)The University of North Carolina, Chapel Hill, Chapel Hill, North Carolina.
(2)Wake Forest University, Winston-Salem, North Carolina.
(3)University of North Carolina, Department of Medicine, Division of
Gastroenterology and Hepatology, 130 Mason Farm Rd, CB 7080, Chapel Hill, NC
27599. Email: tilburg@med.unc.edu.
DOI: 10.5888/pcd13.160046
PMCID: PMC4956478
PMID: 27442993 [Indexed for MEDLINE]
Author information:
(1)Department of Psychiatry and Biobehavioral Sciences, David Geffen School of
Medicine at University of California - Los Angeles, Los Angeles, CA, United
States.
(2)Department of Psychology, Marymount California University, Rancho Palos
Verdes, CA, United States.
DOI: 10.2196/13698
PMCID: PMC6610452
PMID: 31223117
Katalenich B(1), Shi L(2), Liu S(2), Shao H(2), McDuffie R(3), Carpio G(3),
Thethi T(3), Fonseca V(3).
Author information:
(1)Tulane University Health Sciences Center, New Orleans, Louisiana; Southeast
Louisiana Veterans Health Care Systems, New Orleans, Louisiana. Electronic
address: bkatalen@tulane.edu.
(2)Tulane University Health Sciences Center, New Orleans, Louisiana.
(3)Tulane University Health Sciences Center, New Orleans, Louisiana; Southeast
Louisiana Veterans Health Care Systems, New Orleans, Louisiana.
DOI: 10.1016/j.clinthera.2015.03.022
PMCID: PMC4496944
PMID: 25869625 [Indexed for MEDLINE]
1672. Int J Environ Res Public Health. 2019 Jul 29;16(15). pii: E2698. doi:
10.3390/ijerph16152698.
Author information:
(1)Red Cross College of Nursing, Chung-Ang University, Seoul 06974, Korea.
(2)College of Medicine, Division of Cardiology, Gachon University, Incheon 21565,
Korea.
(3)College of Nursing, Gachon University, Incheon 21936, Korea.
(4)Red Cross College of Nursing, Chung-Ang University, Seoul 06974, Korea.
yjson@cau.ac.kr.
Atrial Fibrillation (AF) patients could reduce their risk of stroke by using oral
antithrombotic therapy. However, many older people with AF experience cognitive
impairment and have limited health literacy, which can lead to non-adherence to
antithrombotic treatment. This study aimed to investigate the influence of
cognitive impairment and health literacy on non-adherence to antithrombotic
therapy. The study performed a secondary analysis of baseline data from a
cross-sectional survey of AF patients' self-care behaviors at a tertiary
university hospital in 2018. Data were collected from a total of 277 AF patients
aged 65 years and older, through self-reported questionnaires administered by
face-to-face interviews. Approximately 50.2% of patients were non-adherent to
antithrombotic therapy. Multiple logistic regression analysis revealed that
cognitive impairment independently increased the risk of non-adherence to
antithrombotic therapy (odds ratio = 2.628, 95% confidence interval =
1.424-4.848) after adjustment for confounding factors. However, health literacy
was not associated with non-adherence to antithrombotic therapy. Cognitive
impairment is a significant risk factor for poor adherence to antithrombotic
therapy. Thus, health professionals should periodically assess both cognitive
function after AF diagnosis and adherence to medication in older patients.
Further studies are needed to identify the factors that affect cognitive decline
and non-adherence among AF patients.
DOI: 10.3390/ijerph16152698
PMCID: PMC6696263
PMID: 31362337
Jiang S(1), Yan Z(2), Jing P(3), Li C(4), Zheng T(4), He J(5).
Author information:
(1)Institute of Developmental Psychology, School of Psychology, Beijing Normal
UniversityBeijing, China; Department of Applied Psychology, Wenzhou Medical
UniversityWenzhou, China.
(2)Department of Educational and Counseling Psychology, University at
Albany/State University of New York Albany, NY, USA.
(3)Department of Psychiatry, Ningbo Kangning Hospital Ningbo, China.
(4)Department of Applied Psychology, Wenzhou Medical University Wenzhou, China.
(5)Department of Neurology, The First Affiliated Hospital of Wenzhou Medical
University Wenzhou, China.
DOI: 10.3389/fpsyg.2016.01552
PMCID: PMC5068134
PMID: 27803679
Li QS(1), Tian C(2), McIntyre MH(2), Sun Y(3); 23andMe Research Team(2), Hinds
DA(2), Narayan VA(3).
Author information:
(1)Neuroscience Therapeutic Area, Janssen Research & Development, LLC, 1800
American Blvd, Titusville, NJ, USA. Electronic address: QLi2@its.jnj.com.
(2)23andMe, Inc., Mountain View, CA, USA.
(3)Neuroscience Therapeutic Area, Janssen Research & Development, LLC, 1800
American Blvd, Titusville, NJ, USA.
Copyright © 2019 Janssen Research & Development, LLC. Published by Elsevier B.V.
All rights reserved.
DOI: 10.1016/j.psychres.2019.06.011
PMID: 31207454
Weeks AD(1), Ditai J(2), Ononge S(3), Faragher B(4), Frye LJ(5), Durocher J(6),
Mirembe FM(7), Byamugisha J(8), Winikoff B(9), Alfirevic Z(10).
Author information:
(1)Sanyu Research Unit, Department of Women's and Children's Health, University
of Liverpool, Liverpool Women's Hospital, Crown Street, Liverpool, L8 7SS, UK.
aweeks@liv.ac.uk.
(2)Sanyu Africa Research Institute (SAfRI), Mbale Regional Referral Hospital; and
Sanyu Research Unit, Department of Women's and Children's Health, University of
Liverpool, Liverpool Women's Hospital, Crown Street, Liverpool, L8 7SS, UK.
mocmjjd2@liverpool.ac.uk.
(3)Department of Obstetrics and Gynaecology, Makerere University College of
Health Science, P.O Box 7072, Kampala, Uganda. ononge2006@yahoo.com.
(4)Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.
Brian.Faragher@lstmed.ac.uk.
(5)Gynuity Health Projects, 15 East 26th Street, Suite 801, New York, NY, 10010,
USA. lfrye@gynuity.org.
(6)Gynuity Health Projects, 15 East 26th Street, Suite 801, New York, NY, 10010,
USA. jdurocher@gynuity.org.
(7)Department of Obstetrics and Gynaecology, Makerere University College of
Health Science, P.O Box 7072, Kampala, Uganda. flomir2002@yahoo.com.
(8)Department of Obstetrics and Gynaecology, Makerere University College of
Health Science, P.O Box 7072, Kampala, Uganda. jbyamugisha@gmail.com.
(9)Gynuity Health Projects, 15 East 26th Street, Suite 801, New York, NY, 10010,
USA. BWinikoff@gynuity.org.
(10)Department of Women's and Children's Health, University of Liverpool,
Liverpool Women's Hospital, Crown Street, Liverpool, L8 7SS, UK. zarko@liv.ac.uk.
DOI: 10.1186/s12884-015-0650-9
PMCID: PMC4570250
PMID: 26370443 [Indexed for MEDLINE]
Peyrot M(1), Egede LE(2), Funnell MM(3), Hsu WC(4), Ruggiero L(5), Siminerio
LM(6), Stuckey HL(7).
Author information:
(1)Loyola University Maryland, Baltimore, MD, USA. Electronic address:
mark.peyrot@gmail.com.
(2)Division of General Internal Medicine Froedtert & The Medical College of
Wisconsin, WI, USA.
(3)University of Michigan Medical School, Ann Arbor, MI, USA.
(4)Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
(5)College of Health Sciences, School of Nursing, University of Delaware, Newark,
DE, USA.
(6)University of Pittsburgh Diabetes Institute, Pittsburgh, PA, USA.
(7)The Pennsylvania State University College of Medicine, Hershey, PA, USA.
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.jdiacomp.2018.03.002
PMID: 29709335
Author information:
(1)Department of Psychology, Christ University, Bengaluru, Karnataka, India.
(2)Department of Clinical Psychology, National Institute of Mental Health and
Neuro Sciences, Bengaluru, Karnataka, India.
(3)Department of Psychiatry, National Institute of Mental Health and Neuro
Sciences, Bengaluru, Karnataka, India.
DOI: 10.4103/IJPSYM.IJPSYM_211_17
PMCID: PMC5795680
PMID: 29403131
Coppler PJ, Padmanabhan R, Martin-Gill C, Callaway CW, Yealy DM, Seymour CW.
Prehospital treatment protocols call for intravenous (IV) fluid for patients with
shock, yet the measurement accuracy of administered fluid volume is unknown. The
purpose of the current study was to assess the accuracy of documented and
self-reported fluid volumes administered to medical patients by paramedics during
prehospital care. We conducted a pilot, observational study nested within a
parent cohort study of prehospital biomarkers in a single EMS agency transporting
patients to a tertiary care hospital in Pittsburgh, Pennsylvania over 8 months.
Among eligible nontrauma, noncardiac arrest patients, we studied the
self-reported IV fluid volume on ED arrival by paramedics, documented fluid
volume in the EMS record, and compared those to the mass-derived fluid volume. We
quantified the absolute error between methods, and determined EMS transport times
or initial prehospital systolic blood pressure had any effect on error. We
enrolled 50 patients who received prehospital IV fluid and had mass-derived fluid
volume measured at ED arrival. Of these, 21 (42%) patients had IV fluid volume
subsequently documented in EMS records. The median mass-derived fluid volume was
393 mL [IQR: 264-618 mL]. Mass-derived volume was similar for subjects who did
(386 mL, IQR: 271-642 mL) or did not (399 mL, IQR: 253-602) have documented fluid
administration (p > 0.05). The median self-reported fluid volume was 250 mL [IQR:
150-500 mL] and did not differ by documentation (p > 0.05). The median absolute
error comparing self-reported to mass-derived fluid volume was 109 mL [IQR:
41-205 mL], and less than 250 mL in more than 80% of subjects. The median
absolute error comparing documented fluid to mass-derived fluid volume was 142 mL
[IQR: 64-265 mL], and was less than 250 mL in 71% of subjects. No difference in
absolute error for either self-reported or document fluid volumes were modified
by transport time or prehospital systolic blood pressure. Prehospital IV fluid
administration is variably documented by EMS, and when recorded is typically
within 250 mL of mass-derived fluid volume.KEY WORDS: emergency medical services;
prehospital resuscitation; intravenous fluids; fluids.
DOI: 10.3109/10903127.2015.1051681
PMCID: PMC4701602
PMID: 26270558 [Indexed for MEDLINE]
Welk B(1), McArthur E(2), Ordon M(3), Anderson KK(4), Hayward J(2), Dixon S(4).
Author information:
(1)Department of Surgery, Western University, London, Ontario, Canada2Institute
for Clinical Evaluative Sciences, London, Ontario, Canada3Department of
Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
(2)Institute for Clinical Evaluative Sciences, London, Ontario, Canada.
(3)Division of Urology, Department of Surgery, University of Toronto, Toronto,
Ontario, Canada.
(4)Institute for Clinical Evaluative Sciences, London, Ontario, Canada3Department
of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
Comment in
JAMA Intern Med. 2017 May 1;177(5):691-692.
Ann Intern Med. 2017 Jul 18;167(2):JC9.
J Urol. 2017 Nov;198(5):956-957.
JAMA Intern Med. 2017 Nov 1;177(11):1701-1702.
JAMA Intern Med. 2017 Nov 1;177(11):1702.
Importance: There have been concerns raised by patients and regulatory agencies
regarding serious psychiatric adverse effects associated with 5α-reductase
inhibitors.
Objective: To determine if there is an increased risk of suicide, self-harm, or
depression among older men starting a 5α-reductase inhibitor for prostatic
enlargement.
Design, Setting, and Participants: A population-based, retrospective, matched
cohort study using linked administrative data for 93 197 men ages 66 years or
older (median [IQR] age, 75 [70-80] years) in Ontario, Canada, who initiated a
new prescription for a 5α-reductase inhibitor during the study period (2003
through 2013). Participants were matched (using a propensity score that included
44 of our 96 covariates that included medical comorbidities, medication usage,
and health care system utilization) to an equal number of men not prescribed a
5α-reductase inhibitor.
Exposures: Duration of finasteride or dutasteride usage.
Main Outcomes and Measures: Suicide. Secondary outcomes were self-harm and
depression.
Results: Men who used 5α-reductase inhibitors were not at a significantly
increased risk of suicide (HR, 0.88; 95% CI, 0.53-1.45). Risk of self-harm was
significantly increased during the initial 18 months after 5α-reductase inhibitor
initiation (HR, 1.88; 95% CI, 1.34-2.64), but not thereafter. Incident depression
risk was elevated during the initial 18 months after 5α-reductase inhibitor
initiation (HR, 1.94; 95% CI, 1.73-2.16), and continued to be elevated, but to a
lesser degree, for the remainder of the follow-up period (HR, 1.22; 95% CI,
1.08-1.37). The absolute increases in the event rates for these 2 outcomes were
17 per 100 000 patient-years and 237 per 100 000 patient-years, respectively. The
type of 5α-reductase inhibitor (finasteride or dutasteride) did not significantly
modify the observed associations with suicide, self-harm, and depression.
Conclusions and Relevance: In a large cohort of men ages 66 years or older, we
did not demonstrate an increased risk of suicide associated with 5α-reductase
inhibitor use. However, the risk of self-harm and depression were increased
compared with unexposed men. This is in keeping with postmarketing experience and
patient concerns, and discontinuation of the medication in these circ umstances
may be appropriate.
DOI: 10.1001/jamainternmed.2017.0089
PMCID: PMC5818776
PMID: 28319231 [Indexed for MEDLINE]
Pullen S(1).
Author information:
(1)Department of Rehabilitation Medicine, Emory University School of Medicine,
Atlanta, GA, USA.
BACKGROUND: HIV-related chronic pain has emerged as a major symptom burden among
people living with HIV (PLHIV). Physical therapy (PT) has been shown to be
effective as a non-pharmacological method of chronic pain management in the
general population; however, there is a gap in research examining the role of PT
for chronic pain among PLHIV.
MATERIALS AND METHODS: This study examined the effect of PT on self-reported pain
scores and pain medication usage in PLHIV enrolled in a multidisciplinary HIV
clinic. Data were collected via reviews of patient medical records within a
certain timeframe. Data were gathered from patient charts for two points: initial
PT encounter (Time 1) and PT discharge or visit ≤4 months after initial visit
(Time 2).
RESULTS: Subjects who received PT during this timeframe reported decreased pain
(65.2%), elimination of pain (28.3%), no change in pain (15.2%), and increased
pain (6.5%). Three-quarters of the subjects reported a minimal clinically
important difference (MCID) in pain score, and more than half reported a decrease
in pain score over the MCID. Subjects showed a trend of decreasing pain
medication prescription and usage during the study period.
CONCLUSION: Results of the current study indicate that in this sample, PT
intervention appears to be an effective, cost-effective, non-pharmacological
method to decrease chronic pain in PLHIV.
DOI: 10.2147/HIV.S141903
PMCID: PMC5609779
PMID: 29075140
Author information:
(1)Department of Clinical and Developmental Neuropsychology, University of
Groningen, Groningen, The Netherlands.
DOI: 10.1371/journal.pone.0148841
PMCID: PMC4757442
PMID: 26886218 [Indexed for MEDLINE]
Cummings DM(1), Wu JR(2), Cene C(3), Halladay J(4), Donahue KE(4), Hinderliter
A(5), Miller C(6), Garcia B(6), Penn D(7), Tillman J(8), DeWalt D(9).
Author information:
(1)Department of Family Medicine, Brody School of Medicine at East Carolina
University, Greenville, North Carolina, and School of Pharmacy, University of
North Carolina - Chapel Hill, Chapel Hill, North Carolina.
(2)School of Nursing, University of North Carolina - Chapel Hill, Chapel Hill,
North Carolina.
(3)Department of General Internal Medicine, School of Medicine, University of
North Carolina - Chapel Hill, Chapel Hill, North Carolina.
(4)Department of Family Medicine, School of Medicine, University of North
Carolina - Chapel Hill, Chapel Hill, North Carolina.
(5)Division of Cardiology, School of Medicine, University of North Carolina -
Chapel Hill, Chapel Hill, North Carolina.
(6)Center for Health Promotion/Disease Prevention, Gillings School of Global
Public Health, University of North Carolina - Chapel Hill, Chapel Hill, North
Carolina.
(7)Department of Social Medicine, School of Medicine, University of North
Carolina - Chapel Hill, Chapel Hill, North Carolina.
(8)Community Care Plan of Eastern Carolina, Greenville, North Carolina.
(9)CMS Innovation Center, Centers for Medicare and Medicaid Services, Baltimore,
Maryland.
PURPOSE: Little is known about how perceived social standing versus traditional
socioeconomic characteristics influence medication adherence and blood pressure
(BP) among African American and white patients with hypertension in the rural
southeastern United States.
METHODS: Perceived social standing, socioeconomic characteristics, self-reported
antihypertensive medication adherence, and BP were measured at baseline in a
cohort of rural African American and white patients (n = 495) with uncontrolled
hypertension attending primary care practices. Multivariate models examined the
relationship of perceived social standing and socioeconomic indicators with
medication adherence and systolic BP.
FINDINGS: Medication nonadherence was reported by 40% of patients. Younger age [β
= 0.20; P = .001], African American race [β = -0.30; P = .03], and lower
perceived social standing [β = 0.08; P = .002] but not sex or traditional
socioeconomic characteristics including education and household income, were
significantly associated with lower medication adherence. Race-specific analyses
revealed that this pattern was limited to African Americans and not observed in
whites. In stepwise modeling, older age [β = 0.57, P = .001], African American
race [β = 4.4; P = .03], and lower medication adherence [β = -1.7, P = .01] but
not gender, education, or household income, were significantly associated with
higher systolic BP.
CONCLUSIONS: Lower perceived social standing and age, but not traditional
socioeconomic characteristics, were significantly associated with lower
medication adherence in African Americans. Lower medication adherence was
associated with higher systolic BP. These findings suggest the need for tailored,
culturally relevant medication adherence interventions in rural communities.
DOI: 10.1111/jrh.12138
PMCID: PMC5019540
PMID: 26334761 [Indexed for MEDLINE]
1683. Vasc Health Risk Manag. 2016 Oct 12;12:387-392. eCollection 2016.
Pozzi M(1), Mitchell J(2), Henaine AM(3), Hanna N(4), Safi O(4), Henaine R(2).
Author information:
(1)Department of Adult Cardiac Surgery, "Louis Pradel" Cardiologic Hospital,
Lyon, France.
(2)Department of Congenital Cardiac Surgery, "Louis Pradel" Cardiologic Hospital,
Lyon, France.
(3)Clinical Pharmacology Unit, Lebanese University, Beirut, Lebanon.
(4)Pediatric Unit, "Hotel Dieu de France" Hospital, Saint Joseph University,
Beirut, Lebanon.
DOI: 10.2147/VHRM.S85031
PMCID: PMC5066985
PMID: 27785043 [Indexed for MEDLINE]
The CHESS trial: protocol for the process evaluation of a randomised trial of an
education and self-management intervention for people with chronic headache.
Nichols VP(1), Ellard DR(2), Griffiths FE(3), Underwood M(1), Taylor SJC(4),
Patel S(1); CHESS team.
Author information:
(1)Warwick Clinical Trials Unit, Division of Health Sciences, Warwick Medical
School, University of Warwick, Coventry, CV4 7AL, UK.
(2)Warwick Clinical Trials Unit, Division of Health Sciences, Warwick Medical
School, University of Warwick, Coventry, CV4 7AL, UK. d.r.ellard@warwick.ac.uk.
(3)Division of Health Sciences, Warwick Medical School, University of Warwick,
Coventry, CV4 7AL, UK.
(4)Complex Intervention and Social Practice in Health Care unit, Centre for
Primary Care and Public Health, Blizard Institute, Barts and The London School of
Medicine and Dentistry, Queen Mary University of London, London, E1 2AB, UK.
DOI: 10.1186/s13063-019-3372-x
PMCID: PMC6549347
PMID: 31164158
Author information:
(1)Emergency Department, Wolfson Medical Center, Holon, Israel.
(2)Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
(3)Abarbanel Mental Health Center, Bat Yam, Israel.
(4)Department of Psychology, Bar-Ilan University, Ramat Gan, Israel.
(5)Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Hospice Use and Pain Management in Elderly Nursing Home Residents With Cancer.
Author information:
(1)Department of Quantitative Health Sciences; and Clinical and Population Health
Research Program, Graduate School of Biomedical Sciences, University of
Massachusetts Medical School, Worcester, Massachusetts, USA. Electronic address:
Jacob.Hunnicutt@umassmed.edu.
(2)Department of Quantitative Health Sciences; and Clinical and Population Health
Research Program, Graduate School of Biomedical Sciences, University of
Massachusetts Medical School, Worcester, Massachusetts, USA.
DOI: 10.1016/j.jpainsymman.2016.10.369
PMCID: PMC5337160
PMID: 28042063 [Indexed for MEDLINE]
Bruxvoort K(1), Festo C(2), Cairns M(3), Kalolella A(2), Mayaya F(2), Kachur
SP(4), Schellenberg D(5), Goodman C(6).
Author information:
(1)Department of Global Health and Development, London School of Hygiene and
Tropical Medicine, London, United Kingdom; Impact Evaluation Thematic Group,
Ifakara Health Institute, Dar es Salaam, Tanzania.
(2)Impact Evaluation Thematic Group, Ifakara Health Institute, Dar es Salaam,
Tanzania.
(3)Department of Infectious Disease Epidemiology, London School of Hygiene and
Tropical Medicine, London, United Kingdom.
(4)Malaria Branch, U.S. Centers for Disease Control and Prevention, Atlanta,
United States of America.
(5)Department of Disease Control, London School of Hygiene and Tropical Medicine,
London, United Kingdom.
(6)Department of Global Health and Development, London School of Hygiene and
Tropical Medicine, London, United Kingdom.
BACKGROUND: Self-report is the most common and feasible method for assessing
patient adherence to medication, but can be prone to recall bias and social
desirability bias. Most studies assessing adherence to artemisinin-based
combination therapies (ACTs) have relied on self-report. In this study, we use a
novel customised electronic monitoring device--termed smart blister packs--to
examine the validity of self-reported adherence to artemether-lumefantrine (AL)
in southern Tanzania.
METHODS: Smart blister packs were designed to look identical to locally available
AL blister packs and to record the date and time each tablet was removed from
packaging. Patients obtaining AL at randomly selected health facilities and drug
stores were followed up at home three days later and interviewed about each dose
of AL taken. Blister packs were requested for pill count and extraction of smart
blister pack data.
RESULTS: Data on adherence from both self-report verified by pill count and smart
blister packs were available for 696 of 1,204 patients. There was no difference
between methods in the proportion of patients assessed to have completed
treatment (64% and 67%, respectively). However, the percentage taking the correct
number of pills for each dose at the correct times (timely completion) was higher
by self-report than smart blister packs (37% vs. 24%; p<0.0001). By smart blister
packs, 64% of patients completing treatment did not take the correct number of
pills per dose or did not take each dose at the correct time interval.
CONCLUSION: Smart blister packs resulted in lower estimates of timely completion
of AL and may be less prone to recall and social desirability bias. They may be
useful when data on patterns of adherence are desirable to evaluate treatment
outcomes. Improved methods of collecting self-reported data are needed to
minimise bias and maximise comparability between studies.
DOI: 10.1371/journal.pone.0134275
PMCID: PMC4516331
PMID: 26214848 [Indexed for MEDLINE]
Martin G(1), Patel N(2), Grant Y(2), Jenkins M(3), Gibbs R(4), Bicknell C(4).
Author information:
(1)Department of Surgery and Cancer, Imperial College London, London, United
Kingdom; Imperial Vascular Unit, Imperial College Healthcare NHS Trust, London,
United Kingdom. Electronic address: guy.martin@imperial.ac.uk.
(2)Department of Surgery and Cancer, Imperial College London, London, United
Kingdom.
(3)Imperial Vascular Unit, Imperial College Healthcare NHS Trust, London, United
Kingdom.
(4)Department of Surgery and Cancer, Imperial College London, London, United
Kingdom; Imperial Vascular Unit, Imperial College Healthcare NHS Trust, London,
United Kingdom.
Comment in
J Vasc Surg. 2018 Sep;68(3):699-700.
OBJECTIVE: Early aortic stenting in chronic type B aortic dissection (TBAD) may
lead to long-term benefit, although the optimal treatment strategy is hotly
debated. A robust comparison to outcomes seen in medically managed patients is
challenging as the rate of antihypertensive medication adherence is unknown. The
aims of this study were therefore to identify the rate of antihypertensive
medication adherence and predictors of adherence in TBAD.
METHODS: This was a cross-sectional mixed methods study of patients with TBAD.
Medication adherence was assessed by the eight-item Morisky Medication Adherence
Scale together with an assessment of demographic, behavioral, and psychological
variables and disease-specific knowledge.
RESULTS: There were 47 patients (mean age, 59 years; 81% male) who were recruited
from a tertiary vascular unit. The mean total number of medications taken was 5.8
(2-14), and the mean number of antihypertensive medications was 1.9 (1-6). Of the
47 patients, 20 (43%) reported high levels of medication adherence, 17 (36%)
reported moderate adherence, and 10 (21%) reported low adherence. Previous aortic
surgery was associated with higher levels of adherence (β = 0.332; P = .03), as
was taking a greater number of medications (β = 0.332; P = .026), perceived
benefit from treatment (β = 0.486; P < .001), good memory (β = 0.579; P < .001),
and low fears of side effects (β = 0.272; P < .014).
CONCLUSIONS: Medical management remains the mainstay of treatment in
uncomplicated TBAD; however, the majority of patients are poorly adherent to
their antihypertensive medications. The merits of thoracic endovascular aortic
repair in TBAD are argued, and poor adherence is an important factor in the
debate; one cannot robustly compare two strategies when half of a treatment group
may not be receiving the stated intervention. To develop an evidence-based
treatment strategy for TBAD, we must take into account the direct and indirect
effects of medical therapy and thoracic endovascular aortic repair. Further work
to improve medication adherence and to understand its impact on disease
progression is vital to inform the debate and to deliver the best outcomes for
patients.
Copyright © 2018 Society for Vascular Surgery. Published by Elsevier Inc. All
rights reserved.
DOI: 10.1016/j.jvs.2017.12.063
PMID: 29615356 [Indexed for MEDLINE]
Varleta P(1)(2), Acevedo M(1)(3), Akel C(1)(4), Salinas C(1), Navarrete C(5),
García A(6), Echegoyen C(7), Rodriguez D(8), Gramusset L(9), Leon S(10), Cofré
P(11), Retamal R(12), Romero K(13).
Author information:
(1)Fundación de la Sociedad Chilena de Cardiología y Cirugía Cardiovascular,
Santiago, Chile.
(2)Unidad de Prevención Cardiovascular y Rehabilitación Cardíaca, Centro
Cardiovascular, Hospital DIPRECA, Santiago, Chile.
(3)División de Enfermedades Cardiovasculares, Facultad de Medicina, Pontificia
Universidad Católica de Chile, Santiago, Chile.
(4)Facultad de Medicina, Campus Centro Hospital San Borja Arriarán, Universidad
de Chile, Santiago, Chile.
(5)Departamento de Matemáticas, Facultad de Ciencias, Universidad de la Serena,
La Serena, Chile.
(6)Centro de Salud Familiar Ossandón, Santiago, Chile.
(7)Centro de Salud Familiar Santa Amalia, Santiago, Chile.
(8)Centro de Salud Familiar Presidenta Michelle Bachelet, Santiago, Chile.
(9)Centro de Salud Familiar Gustavo Molina, Santiago, Chile.
(10)Centro de Salud Familiar Ignacio Domeiko, Santiago, Chile.
(11)Centro de Salud Familiar Dr. Anibal Ariztía, Santiago, Chile.
(12)Centro de Salud Familiar Santa Julia, Santiago, Chile.
(13)Centro de Salud Familiar Padre Gerardo Whelan, Santiago, Chile.
Comment in
J Clin Hypertens (Greenwich). 2017 Dec;19(12):1285-1287.
DOI: 10.1111/jch.13098
PMID: 28941056 [Indexed for MEDLINE]
Medication usage change in older people (65+) in England over 20 years: findings
from CFAS I and CFAS II.
Gao L(1), Maidment I(2), Matthews FE(1)(3), Robinson L(3), Brayne C(4); Medical
Research Council Cognitive Function and Ageing Study.
Author information:
(1)MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK.
(2)School of Life and Health Sciences, Medicines and Devices in Ageing Cluster
Lead, Aston Research Centre for Healthy Ageing (ARCHA), Aston University,
Birmingham, UK.
(3)Institute of Health and Society, Faculty of Medicine, Newcastle University,
Newcastle, UK.
(4)Department of Public Health and Primary Care, Cambridge Institute of Public
Health, Cambridge, UK.
Comment in
Age Ageing. 2018 Mar 1;47(2):160-161.
Background: medical practice has changed over the last decades reflecting the
ageing population, when multi-morbidity requiring multiple medications is more
common.
Objective: describe and quantify self-reported medicine use including both
prescription and over the counter medicines in two comparable population-based
studies of older people (65+) in England and to assess the nature and scale of
polypharmacy.
Methods: data used were from two separate population-based studies; the Cognitive
Function Ageing Study I and II. Descriptive analyses were performed to summarise
and quantify general medicine use. Negative binomial regression models were
fitted to determine factors associated with the number of medicines used.
Results: medication use, including both prescribed medicines and over the counter
products has increased dramatically over the last 2 decades. The number of people
taking five or more items quadrupled from 12 to 49%, while the proportion of
people who did not take any medication has decreased from around 1 in 5 to 1 in
13. Cardiovascular drugs were the most frequently taken medication. Polypharmacy
is associated with increases in the number of diagnosed long-term conditions.
Conclusions: comparison between CFAS I and II reveals marked increases in
medication usage and polypharmacy in the older population. The influence of
healthcare organisation, introduction of new guidelines and technology changes
leading to diagnosis of earlier, milder chronic diseases and treatment may be
contributing to this changing pattern. Further research is needed to develop
practical solutions to optimise medication management in older people, reducing
the harming associated with medication.
© The Author 2017. Published by Oxford University Press on behalf of the British
Geriatrics Society.All rights reserved. For permissions, please email:
journals.permissions@oup.com
DOI: 10.1093/ageing/afx158
PMCID: PMC6037294
PMID: 29036509
Medication adherence among men who have sex with men at risk for HIV infection in
the United States: implications for pre-exposure prophylaxis implementation.
Liu AY(1), Hessol NA, Vittinghoff E, Amico KR, Kroboth E, Fuchs J, Irvin R,
Sineath RC, Sanchez T, Sullivan PS, Buchbinder SP.
Author information:
(1)1 Bridge HIV, San Francisco Department of Public Health , San Francisco,
California.
DOI: 10.1089/apc.2014.0195
PMCID: PMC4250955
PMID: 25396706 [Indexed for MEDLINE]
1692. Qual Health Res. 2017 Jul;27(8):1177-1189. doi: 10.1177/1049732317697674.
Epub
2017 Apr 11.
Fields EL(1), Bogart LM(2), Thurston IB(3), Hu CH(4), Skeer MR(5)(6), Safren
SA(7), Mimiaga MJ(5)(8).
Author information:
(1)1 Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
(2)2 RAND Corporation, Santa Monica, California, USA.
(3)3 University of Memphis, Memphis, Tennessee, USA.
(4)4 University of Minnesota, Minneapolis, Minnesota, USA.
(5)5 Fenway Health, Boston, Massachusetts, USA.
(6)6 Tufts University, Boston, Massachusetts, USA.
(7)7 University of Miami, Coral Gables, Florida, USA.
(8)8 Brown University, Providence, Rhode Island, USA.
Medication adherence among youth living with HIV (28%-69%) is often insufficient
for viral suppression. The psychosocial context of adherence barriers is complex.
We sought to qualitatively understand adherence barriers among behaviorally
infected and perinatally infected youth and develop an intervention specific to
their needs. We conducted in-depth interviews with 30 youth living with HIV (aged
14-24 years) and analyzed transcripts using the constant comparative method.
Barriers were influenced by clinical and psychosocial factors. Perinatally
infected youth barriers included reactance, complicated regimens, HIV fatigue,
and difficulty transitioning to autonomous care. Behaviorally infected youth
barriers included HIV-related shame and difficulty initiating medication. Both
groups reported low risk perception, medication as a reminder of HIV, and
nondisclosure, but described different contexts to these common barriers. Common
and unique barriers emerged for behaviorally infected and perinatally infected
youth reflecting varying HIV experiences and psychosocial contexts. We developed
a customizable intervention addressing identified barriers and their psychosocial
antecedents.
DOI: 10.1177/1049732317697674
PMCID: PMC5953432
PMID: 28682737 [Indexed for MEDLINE]
Health literacy, cognitive function, proper use, and adherence to inhaled asthma
controller medications among older adults with asthma.
O'Conor R(1), Wolf MS(2), Smith SG(2), Martynenko M(3), Vicencio DP(4), Sano
M(5), Wisnivesky JP(4), Federman AD(3).
Author information:
(1)Division of General Internal Medicine, Feinberg School of Medicine,
Northwestern University, Chicago, IL. Electronic address:
r-oconor@northwestern.edu.
(2)Division of General Internal Medicine, Feinberg School of Medicine,
Northwestern University, Chicago, IL.
(3)Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York,
NY.
(4)Department of Medicine, Mercy Hospital and Medical Center, Chicago, IL.
(5)Division of Pulmonary, Critical Care and Sleep Medicine, James J. Peters VA
Medical Center, Bronx, Icahn School of Medicine at Mount Sinai, New York, NY.
DOI: 10.1378/chest.14-0914
PMCID: PMC4420182
PMID: 25275432 [Indexed for MEDLINE]
Author information:
(1)School of Computing, Faculty of Technology, University of Portmouth,
Portsmouth, United Kingdom.
(2)School of Pharmacy and Biomedical Sciences, Faculty of Science, University of
Portmouth, Portsmouth, United Kingdom.
(#)Contributed equally
BACKGROUND: The National Health Service (NHS) England spent £15.5 billion on
medication in 2015. More than a third of patients affected by at least one
long-term condition do not adhere to their drug regime. Many interventions have
been trialed to improve medication adherence. One promising innovation is the
electronic personal health record.
OBJECTIVE: This systematic literature review aims to identify the important
design features of personal health records to improve medication adherence for
patients with long-term conditions.
METHODS: This protocol follows the Preferred Reporting Items for Systematic
Reviews and Meta-Analyses Protocol (PRISMA-P 2015) statement. The following
databases will be searched for relevant articles: PubMed, Science Direct, BioMed
Central, Cumulative Index to Nursing and Allied Health Literature, Cochrane
Database of Systematic Reviews, and the Cochrane Central Register of Controlled
Trials. Studies published in the last fifteen years, in English, will be included
if the participants are adults who were treated outside the hospital, have the
ability to self-administer their medication, and have at least one long-term
condition. The review will exclude commercial or political sources and papers
without references. Papers that research pediatrics, pregnant, or terminally ill
patients will also be excluded, since their medication management is typically
more complex.
RESULTS: One reviewer will screen the included studies, extract the relevant
data, and assess the quality of evidence utilizing the Grading of Recommendations
Assessment, Development, and Evaluation system and the risk of bias using the
Cochrane RevMan tool. The second reviewer will assess the quality of 25% of the
included studies to assess interrater agreement. Any disagreement will be solved
by a third reviewer. Only studies of high and moderate quality will be included
for narrative synthesis.
CONCLUSIONS: NHS policy assumes that increasing usage of personal health records
by citizens will reduce demand on health care services. There is limited
evidence, however, that the use of health apps can improve patient outcomes, and,
to our knowledge, this is the first systematic literature review aiming to
identify important design features of the personal health record which may
improve medication adherence in the adult population with long-term conditions.
TRIAL REGISTRATION: PROSPERO CRD42017060542;
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=60542 (Archived
by WebCite at http://www.webcitation.org/6zeuWXxVh).
REGISTERED REPORT IDENTIFIER: RR1-10.2196/9778.
DOI: 10.2196/resprot.9778
PMCID: PMC6116916
PMID: 29954729
Naqvi AA(1), Hassali MA(1), Rizvi M(2), Zehra A(2), Iffat W(2), Haseeb A(3),
Jamshed S(4).
Author information:
(1)Discipline of Social and Administrative Pharmacy, School of Pharmaceutical
Sciences, Universiti Sains Malaysia (USM), Penang, Malaysia.
(2)DOW College of Pharmacy, DOW University of Health Sciences, Karachi, Pakistan.
(3)Department of Clinical Pharmacy, College of Pharmacy, Umm Al Qura University,
Makkah, Saudi Arabia.
(4)Department of Pharmacy Practice, Kulliyah of Pharmacy, International Islamic
University Malaysia, Kuantan, Malaysia.
DOI: 10.3389/fphar.2018.01124
PMCID: PMC6189444
PMID: 30356775
Gatwood J(1), Balkrishnan R(2), Erickson SR(2), An LC(3), Piette JD(4), Farris
KB(2).
Author information:
(1)University of Michigan College of Pharmacy, 428 Church St., Ann Arbor, MI
48109, USA. Electronic address: gatwood@umich.edu.
(2)University of Michigan College of Pharmacy, 428 Church St., Ann Arbor, MI
48109, USA.
(3)University of Michigan Medical School, Ann Arbor, MI, USA; University of
Michigan Center for Health Communication Research, Ann Arbor, MI, USA.
(4)University of Michigan Medical School, Ann Arbor, MI, USA; Department of
Veterans Affairs, Ann Arbor, MI, USA.
DOI: 10.1016/j.sapharm.2014.01.002
PMCID: PMC4182163
PMID: 24603134 [Indexed for MEDLINE]
Author information:
(1)Pharmacology and Pharmaceutical Care Laboratory, Faculty of Pharmacy,
University of Coimbra, Coimbra, Portugal.
(2)Cognitive and Behavioural Center for Research and Intervention (CINEICC),
Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra,
Portugal.
(3)Institute for Biomedical Imaging and life Sciences, Faculty of Pharmacy,
University of Coimbra, Coimbra, Portugal.
(4)Department of Social Pharmacy, Faculty of Pharmacy, University of Lisbon,
Lisboa, Portugal. Electronic address: f-llimos@ff.ul.pt.
Comment in
Rev Port Cardiol. 2018 Apr;37(4):305-306.
DOI: 10.1016/j.repc.2017.09.017
PMID: 29628355 [Indexed for MEDLINE]
Dreer LE(1), Owsley C(1), Campbell L(2), Gao L(1), Wood A(1), Girkin CA(1).
Author information:
(1)a Department of Ophthalmology , University of Alabama at Birmingham ,
Birmingham , AL , USA and.
(2)b Department of Psychology , East Carolina University , Greenville , NC , USA.
DOI: 10.3109/02713683.2014.1002045
PMCID: PMC4516706
PMID: 25625187 [Indexed for MEDLINE]
Kavanaugh A(1), Papp K(2), Gottlieb AB(3), de Jong EMGJ(4), Chakravarty SD(5)(6),
Kafka S(5), Langholff W(7), Farahi K(5), Srivastava B(5), Scher JU(8).
Author information:
(1)1Division of Rheumatology, Allergy and Immunology, Department of Medicine,
University of California, San Diego, CA USA.
(2)2K Papp Clinical Research and Probity Medical Research Inc., Waterloo, ON
Canada.
(3)3New York Medical College, Metropolitan Hospital, New York, NY USA.
(4)Department of Dermatology, Radboud University Medical Center, and Radboud
University, Nijmegen, The Netherlands.
(5)5Janssen Scientific Affairs, LLC, Horsham, PA USA.
(6)6Drexel University College of Medicine, Philadelphia, PA USA.
(7)7Janssen Research & Development, LLC, Spring House, PA USA.
(8)8Division of Rheumatology, New York University School of Medicine and Hospital
for Joint Diseases, 301 East 17th Street, Room 1608, New York, NY 10003 USA.
DOI: 10.1186/s41927-018-0034-7
PMCID: PMC6390609
PMID: 30886979
1700. BMC Health Serv Res. 2019 Apr 24;19(1):246. doi: 10.1186/s12913-019-4059-4.
Author information:
(1)Department of Psychology, University of Kansas, Lawrence, KS, USA.
(2)Department of Preventive Medicine and Public Health, University of Kansas
Medical Center, Mailstop 1008, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA.
(3)Department of Preventive Medicine and Public Health, University of Kansas
Medical Center, Mailstop 1008, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA.
KRICHTER@kumc.edu.
BACKGROUND: Hospital-initiated smoking cessation interventions utilizing
pharmacotherapy increase post-discharge quit rates. Use of smoking cessation
medications following discharge may further increase quit rates. This study aims
to identify individual, smoking-related and hospitalization-related predictors of
engagement in three different steps in the smoking cessation pharmacotherapy
utilization process: 1) receiving medications as inpatient, 2) being discharged
with a prescription and 3) using medications at 1-month post-hospitalization,
while accounting for associations between these steps.
METHODS: Study data come from a clinical trial (N = 1054) of hospitalized smokers
interested in quitting who were randomized to recieve referral to a quitline via
either warm handoff or fax. Variables were from the electronic health record, the
state tobacco quitline, and participant self-report. Relationships among the
predictors and the steps in cessation medication utilization were assessed using
bivariate analyses and multivariable path analysis.
RESULTS: Twenty-eight percent of patients reported using medication at 1-month
post-discharge. Receipt of smoking cessation medications while hospitalized
(OR = 2.09, 95%CI [1.39, 3.15], p < .001) and discharge with a script (OR = 4.88,
95%CI [3.34, 7.13], p < .001) were independently associated with medication use
at 1-month post-hospitalization. The path analysis also revealed that the
likelihood of being discharged with a script was strongly influenced by receipt
of medication as an inpatient (OR = 6.61, 95%CI [4.66, 9.38], p < .001). A number
of other treatment- and individual-level factors were associated with medication
use in the hospital, receipt of a script, and use post-discharge.
CONCLUSIONS: To encourage post-discharge smoking cessation medication use,
concerted effort should be made to engage smokers in tobacco treatment while in
hospital. The individual and hospital-level factors associated with each step in
the medication utilization process provide good potential targets for future
implementation research to optimize treatment delivery and outcomes.
TRIAL REGISTRATION: Number: NCT01305928 . Date registered: February 24, 2011.
DOI: 10.1186/s12913-019-4059-4
PMCID: PMC6480776
PMID: 31018852 [Indexed for MEDLINE]
Kuntz JL(1), Safford MM(2), Singh JA(2), Phansalkar S(3), Slight SP(3), Her
QL(4), Lapointe NA(5), Mathews R(5), O'Brien E(5), Brinkman WB(6), Hommel K(6),
Farmer KC(7), Klinger E(8), Maniam N(4), Sobko HJ(2), Bailey SC(9), Cho I(8),
Rumptz MH(10), Vandermeer ML(10), Hornbrook MC(10).
Author information:
(1)Center for Health Research, Kaiser Permanente Northwest, Portland, USA.
Electronic address: Jennifer.l.kuntz@kpchr.org.
(2)Division Preventive Medicine, Department of Medicine, University of Alabama at
Birmingham, USA.
(3)Partners Healthcare Systems, Inc., Wellesley, USA; Brigham and Women's
Hospital and Harvard Medical School, Boston, USA.
(4)Partners Healthcare Systems, Inc., Wellesley, USA.
(5)Duke University, Durham, USA.
(6)Cincinnati Children's Hospital and Medical Center, Cincinnati, USA.
(7)The University of Oklahoma College of Pharmacy, Oklahoma City, USA.
(8)Brigham and Women's Hospital and Harvard Medical School, Boston, USA.
(9)University of North Carolina, Eshelman School of Pharmacy, Chapel Hill, USA.
(10)Center for Health Research, Kaiser Permanente Northwest, Portland, USA.
DOI: 10.1016/j.pec.2014.08.021
PMCID: PMC5830099
PMID: 25264309 [Indexed for MEDLINE]
Tonozzi TR(1), Braunstein GD(1), Kammesheidt A(1), Curran C(2), Golshan S(3),
Kelsoe J(3).
Author information:
(1)Pathway Genomics, San Diego, CA 92121, USA.
(2)Patients Like Me, Cambridge, MA 02142, USA.
(3)Department of Psychiatry, University of California, San Diego, CA 92093, USA.
Salari A(1), Rouhi Balasi L(2), Ashouri A(3), Moaddab F(1), Zaersabet F(1),
Nourisaeed A(4).
Author information:
(1)Department of Cardiology, Cardiovascular Diseases Research Center, Heshmat
Hospital, Faculty of Medicine, Guilan University of Medical Sciences, Rasht,
Iran.
(2)Department of Nursing, Faculty of Nursing and Midwifery, Ahvaz Jundishapur
University of Medical Sciences, Ahvaz, Iran.
(3)Department of Health Education and Promotion, Health and Environment Research
Center, Faculty of Health, Guilan University of Medical Sciences, Rasht, Iran.
(4)Department of Psychology, Islamic Azad University of Guilan, Rasht, Iran.
DOI: 10.15171/jcs.2018.032
PMCID: PMC6311628
PMID: 30607362
Author information:
(1)Pharmacy Practice, International Islamic University Malaysia, Selayang,
Malaysia.
(2)University of Veterinary and Animal Sciences, Lahore, Pakistan.
(3)Department of Internal Medicine, College of Medicine and Health Sciences,
United Arab Emirates University, Al Ain, United Arab Emirates.
DOI: 10.3389/fpubh.2018.00244
PMCID: PMC6129588
PMID: 30234088
Author information:
(1)Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol
University, Bangkok, Thailand.
DOI: 10.12932/AP-010217-0002
PMID: 28938838 [Indexed for MEDLINE]
Author information:
(1)Department of Psychosis Studies, Institute of Psychiatry, Psychology &
Neuroscience, King's College London, London, UK.
(2)Wellcome Trust Centre for Neuroimaging, University College London, London, UK.
© The Author 2016. Published by Oxford University Press on behalf of the Maryland
Psychiatric Research Center. All rights reserved. For permissions, please email:
journals.permissions@oup.com.
DOI: 10.1093/schbul/sbw092
PMCID: PMC5605270
PMID: 27384054 [Indexed for MEDLINE]
1707. Med Princ Pract. 2018;27(4):387-391. doi: 10.1159/000490145. Epub 2018 Jun
22.
Aggelopoulou E(1), Tzortzis S(2), Tsiourantani F(1), Agrios I(2), Lazaridis K(2).
Author information:
(1)3rd Department of Internal Medicine, 417 Army Share Fund Hospital, Athens,
Greece.
(2)Department of Cardiology, 417 Army Share Fund Hospital, Athens, Greece.
DOI: 10.1159/000490145
PMCID: PMC6170900
PMID: 29936503 [Indexed for MEDLINE]
Paton C(1), Adams CE(2), Dye S(3), Fagan E(1), Okocha C(4), Barnes TR(1)(5).
Author information:
(1)1 Royal College of Psychiatrists, Centre for Quality Improvement, London, UK.
(2)2 Institute of Mental Health, University of Nottingham, Nottingham, UK.
(3)3 Ipswich Access and Treatment Team, Norfolk and Suffolk NHS Foundation Trust,
Ipswich, UK.
(4)4 Oxleas NHS Foundation Trust, Dartford, UK.
(5)5 Centre for Psychiatry, Imperial College London, London, UK.
DOI: 10.1177/0269881118817170
PMCID: PMC6431784
PMID: 30565486
Author information:
(1)Department of Family Medicine, CAPHRI School for Public Health and Primary
Care, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.
(2)Department of Family Medicine, CAPHRI School for Public Health and Primary
Care, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.
eefje.debont@maastrichtuniversity.nl.
(3)Dutch Institute for Rational Use of Medicine, P.O. Box 3089, 3502 GB, Utrecht,
The Netherlands.
DOI: 10.1007/s11096-016-0353-y
PMCID: PMC5031752
PMID: 27450505 [Indexed for MEDLINE]
Novick D(1), Montgomery W(2), Moneta V(3), Peng X(4), Brugnoli R(5), Haro JM(3).
Author information:
(1)Eli Lilly and Company, Windlesham, Surrey, UK.
(2)Eli Lilly Australia Pty Ltd, West Ryde, Australia.
(3)Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona,
Spain.
(4)Eli Lilly and Company, Indianapolis, IN, USA.
(5)Department of Neuroscience, School of Medicine, Sapienza University of Rome,
Rome, Italy.
DOI: 10.2147/PPA.S68432
PMCID: PMC4362981
PMID: 25792815
Author information:
(1)Department of Psychiatry, JJM Medical College, Davangere, Karnataka, India.
DOI: 10.4103/psychiatry.IndianJPsychiatry_24_17
PMCID: PMC5419016
PMID: 28529363
Author information:
(1)Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology,
National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug
Abuse, National Institutes of Health, Bethesda, MD, USA.
(2)Office of the Clinical Director, National Institute on Alcohol Abuse and
Alcoholism, National Institutes of Health, Bethesda, MD, USA.
(3)Clinical Center Nursing Department, National Institutes of Health, Bethesda,
MD, USA.
(4)Center for Alcohol and Addiction Studies, Department of Behavioral and Social
Sciences, Brown University, Providence, RI, USA.
DOI: 10.1038/tp.2017.71
PMCID: PMC5416708
PMID: 28440812 [Indexed for MEDLINE]
1713. Behav Sci (Basel). 2017 Sep 15;7(3). pii: E62. doi: 10.3390/bs7030062.
Author information:
(1)Department of Family Health, Mahidol University, Bangkok 10400, Thailand.
adirian491@yahoo.com.
(2)Department of Nursing, College of Health, Mega Rezky Makassar, Makassar 90245,
Indonesia. adirian491@yahoo.com.
(3)Department of Family Health, Mahidol University, Bangkok 10400, Thailand.
kanittha.cha@mahidol.ac.th.
(4)Department of Health Education and Behavioral Science, Mahidol University,
Bangkok 10400, Thailand. paranee.vat@mahidol.ac.th.
DOI: 10.3390/bs7030062
PMCID: PMC5618070
PMID: 28914815
1714. Pain Med. 2015 Apr;16(4):706-14. doi: 10.1111/pme.12701. Epub 2015 Feb 3.
Merlin JS(1), Walcott M, Kerns R, Bair MJ, Burgio KL, Turan JM.
Author information:
(1)Division of Infectious Diseases, Department of Medicine, University of Alabama
at Birmingham, Birmingham, Alabama; Division of Gerontology, Geriatrics, and
Palliative Care, University of Alabama at Birmingham, Birmingham, Alabama, USA.
DOI: 10.1111/pme.12701
PMCID: PMC4390451
PMID: 25645646 [Indexed for MEDLINE]
1715. Health Expect. 2015 Oct;18(5):1270-81. doi: 10.1111/hex.12101. Epub 2013 Jun
20.
Saleem F(1), Hassali MA(2), Shafie AA(1), Ul Haq N(1), Farooqui M(3), Aljadhay
H(4), Ahmad FU(5).
Author information:
(1)Discipline of Social and Administrative Pharmacy, School of Pharmaceutical
Sciences, Universiti Sains Malaysia, Penang, Malaysia.
(2)School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang,
Malaysia.
(3)Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Penang, Malaysia.
(4)College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
(5)Discipline of Physiology, School of Pharmaceutical Sciences, Universiti Sains
Malaysia, Penang, Malaysia.
DOI: 10.1111/hex.12101
PMCID: PMC5060860
PMID: 23786500 [Indexed for MEDLINE]
Assessing oral medication adherence among patients with type 2 diabetes mellitus
treated with polytherapy in a developed Asian community: a cross-sectional study.
Lee CS(1), Tan JHM(1), Sankari U(1), Koh YLE(1), Tan NC(1)(2).
Author information:
(1)SingHealth Polyclinics, Singapore, Singapore.
(2)Duke-NUS Medical School, Singapore, Singapore.
OBJECTIVES: The disease burden of type 2 diabetes mellitus (T2DM) is rising due
to suboptimal glycaemic control leading to vascular complications. Medication
adherence (MA) directly influences glycaemic control and clinical consequences.
This study aimed to assess the MA of patients with T2DM and identify associated
factors.
DESIGN: Analysis of data from a cross-sectional survey and electronic medical
records.
SETTING: Primary care outpatient clinic in Singapore.
PARTICIPANTS: Adult patients with T2DM.
MAIN OUTCOME MEASURES: MA to each prescribed oral hypoglycaemic agent (OHA) was
measured using the five-question Medication Adherence Report Scale (MARS-5). Low
MA is defined as a MARS-R score of <25. Demographic data, clinical
characteristics and investigation results were collected to identify factors that
are associated with low MA.
RESULTS: The study population comprised 382 patients with a slight female
predominance (53.4%) and a mean±SD age of 62.0±10.4 years. 57.1% of the patients
had low MA to at least one OHA. Univariate analysis showed that patients who were
younger, of Chinese ethnicity, married or widowed, self-administering their
medications or taking fewer (four or less) daily medications tended to have low
MA to OHA. Logistic regression revealed that younger age (OR 0.97; 95% CI 0.95
to0.99), Chinese ethnicity (OR 2.80; 95% CI 1.53 to5.15) and poorer glycaemic
control (HbA1c level) (OR 1.27; 95% CI 1.06 to1.51) were associated with low MA
to OHA.
CONCLUSIONS: Younger patients with T2DM and of Chinese ethnicity were susceptible
to low MA to OHA, which was associated with poorer glycaemic control. Polytherapy
was not associated with low MA.
© Article author(s) (or their employer(s) unless otherwise stated in the text of
the article) 2017. All rights reserved. No commercial use is permitted unless
otherwise expressly granted.
DOI: 10.1136/bmjopen-2017-016317
PMCID: PMC5640112
PMID: 28912194 [Indexed for MEDLINE]
Author information:
(1)Jackson Heart Study Vanguard Center of Oxford, Center for Health Behavior
Research, Department of Health, Exercise Science and Recreation Management, The
University of Mississippi, University, MS 38677, United States.
(2)Division of Gastroenterology & Hepatology and Department of Preventive
Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611,
United States.
DOI: 10.1016/j.pmedr.2015.12.011
PMCID: PMC4733094
PMID: 26844199
Author information:
(1)Ambulatorio de Imunodeficiencias Secundarias, Departamento de Dermatologia,
Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de Sao
Paulo, Sao Paulo, SP, BR.
(2)Instituto de Medicina Tropical de Sao Paulo, Sao Paulo, SP, BR.
OBJECTIVES: The aim of the present study was to investigate the prevalence of
depression and adherence to antiretroviral treatment in two groups of
individuals: men who have sex with men (MSM) and men who have sex with women
(MSW).
METHODS: Two hundred and sixteen participants (MSM=116; MSW=100) who visited the
Clinics Hospital of the School of the Medicine of the University of São Paulo
completed two independent surveys (the BECK Depression Inventory and an adherence
self-declared questionnaire) to evaluate their depression status and adherence to
antiretroviral treatment, respectively.
RESULTS: The study highlighted a positive relationship between depression and low
adherence to Highly Active Antiretroviral Therapy in these patients regardless of
age and sexual orientation. In addition, MSM subjects were two times more prone
than MSW subjects to develop depression symptoms. White or mixed race men showed
7.6 times greater adherence to treatment than black men. The probability of
complete adherence to treatment was 3.8 times higher in non-depressed subjects
than in depressed subjects regardless of their ethnicity. The chance of
developing depression was 4.17 times higher for an individual with non-adherent
behavior than for an adherent individual.
CONCLUSIONS: Individuals with low adherence rates have proportionally higher
depression rates. Depressed men tend to show less adherence to treatment. Black
but not mixed race or white men show less adherence to Highly Active
Antiretroviral Therapy and have a greater chance of developing depression, which
directly interferes with adherence. The chances of developing depression are four
times greater for a patient with non-adherent behavior than for a patient with
adherent behavior.
DOI: 10.6061/clinics/2017(12)05
PMCID: PMC5738567
PMID: 29319720 [Indexed for MEDLINE]
Author information:
(1)Faculdades Integradas Pitágoras. Av. Profa. Aida Mainartina Paraiso 80,
Ibituruna. 39408-007 Montes Claros MG Brasil. vitorhipolito@bol.com.br.
(2)Departamento de Saúde da Mulher e da Criança, Universidade Estadual de Montes
Claros. Montes Claros MG Brasil.
The scope of this study was to investigate the prevalence and factors associated
with negative self-rated health in menopausal women registered with the Family
Health Strategy in a Brazilian urban center. It is a cross-sectional study with a
random sample of menopausal women. A validated instrument addressing
sociodemographic and behavioral data related to self-rated health status was
used. The association between the variables studied and negative self-rated
health was assessed by bivariate analysis followed by Poisson regression with
robust variance, in a hierarchical model. The prevalence of negative self-rated
health among the population studied was 41.6%, among 761 women. Among women aged
52-65 years old, 49.2% had negative self-rated health. Age corresponding to
post-menopause, education up to eight years of study, having a partner, not
having a formal job, current tobacco use and physical inactivity were associated
with negative self-rated health. The presence of menopausal symptoms, overweight
and obesity, the current use of medication and the presence of chronic diseases
were also associated with negative self-rated health in the final model. The
associations observed point to the need for health promotion activities aimed at
menopausal women.
Living with asthma and chronic obstructive airways disease: Using technology to
support self-management - An overview.
Morrison D(1), Mair FS(1), Yardley L(2), Kirby S(2), Thomas M(3).
Author information:
(1)1 General Practice and Primary Care, Institute of Health and Wellbeing,
University of Glasgow, Glasgow, UK.
(2)2 Department of Psychology, University of Southampton, Highfield, Southampton,
UK.
(3)3 Primary Care Research, Aldermoor Health Centre, University of Southampton,
Aldermoor Close, Southampton, UK.
DOI: 10.1177/1479972316660977
PMCID: PMC5729728
PMID: 27512084 [Indexed for MEDLINE]
1721. Asian Nurs Res (Korean Soc Nurs Sci). 2015 Dec;9(4):291-7. doi:
10.1016/j.anr.2015.07.005. Epub 2015 Oct 22.
Risk Factor-tailored Small Group Education for Patients with First-time Acute
Coronary Syndrome.
Author information:
(1)College of Nursing, Hanynag University, Seoul, South Korea. Electronic
address: seon9772@hanyang.ac.kr.
(2)College of Nursing, Gachon University, Incheon, South Korea.
PURPOSE: The purpose of this study was to evaluate the effects of a risk
factor-tailored small group education on anxiety and depressive symptoms,
self-efficacy and self-care compliance in patients with first-time acute coronary
syndrome (ACS) for 12-month follow-up.
METHODS: A quasi-experimental pretest and post-test design was used. Patients
were recruited from a national university hospital from 2010 to 2011 in Korea.
The group education consisted of a 60-minute long video developed using
multimedia contents including voice-recorded texts, flash animation, and video
clips, with nurses' dialogue. The intervention group (n = 34) participated in
group education using the multimedia video in a small group of patients with
similar risk factors, and received periodic telephone counseling and text
messages. The control group (n = 40) received usual care and counseling upon
request.
RESULTS: Depressive symptoms decreased, and self-efficacy and self-care
compliance in the areas of medication, exercise, and healthy diet practice
significantly increased in patients in the intervention group, compared with
those in the control group.
CONCLUSIONS: Risk factor-tailored small group education and periodic text message
were an effective strategy for decreasing depression, and increasing
self-efficacy and long-term compliance with lifestyle changes in patients with
first-time ACS. We suggested that risk factor-tailored small group education need
to be given for first-time ACS patients for psychological support and behavioral
change in clinical practice. It is also comparable to individual approach to
encourage psychological and behavioral change.
DOI: 10.1016/j.anr.2015.07.005
PMID: 26724237 [Indexed for MEDLINE]
Author information:
(1)Department of Epidemiology and Preventive Medicine, Faculty of Medicine
Nursing and Health Science, Monash University, The Alfred Centre, 99 Commercial
Road, Melbourne, Victoria, 3004, Australia. Michaela.riddell@monash.edu.
(2)Deakin Population Health Strategic Research Centre, Deakin University,
Melbourne, Australia.
(3)School of Health Sciences, University of Tampere, Tampere, Finland.
(4)Department of Epidemiology and Preventive Medicine, Faculty of Medicine
Nursing and Health Science, Monash University, The Alfred Centre, 99 Commercial
Road, Melbourne, Victoria, 3004, Australia.
(5)Institute of Chronic Disease Control, Beijing Centers for Disease Control and
Prevention, Beijing, People's Republic of China.
(6)Melbourne School of Population and Global Health, University of Melbourne,
Melbourne, Australia.
BACKGROUND: The 2013 Global Burden of Disease Study demonstrated the increasing
burden of diabetes and the challenge it poses to the health systems of all
countries. The chronic and complex nature of diabetes requires active
self-management by patients in addition to clinical management in order to
achieve optimal glycaemic control and appropriate use of available clinical
services. This study is an evaluation of a "real world" peer support program
aimed at improving the control and management of type 2 diabetes (T2DM) in
Australia.
METHODS: The trial used a randomised cluster design with a peer support
intervention and routine care control arms and 12-month follow up. Participants
in both arms received a standardised session of self-management education at
baseline. The intervention program comprised monthly community-based group
meetings over 12 months led by trained peer supporters and active encouragement
to use primary health care and other community resources and supports related to
diabetes. Clinical, behavioural and other measures were collected at baseline, 6
and 12 months. The primary outcome was the predicted 5 year cardiovascular
disease risk using the United Kingdom Prospective Diabetes Study (UKPDS) Risk
Equation at 12 months. Secondary outcomes included clinical measures, quality of
life, measures of support, psychosocial functioning and lifestyle measures.
RESULTS: Eleven of 12 planned groups were successfully implemented in the
intervention arm. Both the usual care and the intervention arms demonstrated a
small reduction in 5 year UKPDS risk and the mean values for biochemical and
anthropometric outcomes were close to target at 12 months. There were some small
positive changes in self-management behaviours.
CONCLUSIONS: The positive changes in self-management behaviours among
intervention participants were not sufficient to reduce cardiovascular risk,
possibly because approximately half of the study participants already had quite
well controlled T2DM at baseline. Future research needs to address how to enhance
community based programs so that they reach and benefit those most in need of
resources and supports to improve metabolic control and associated clinical
outcomes.
TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry (ANZCTR)
ACTRN12609000469213 . Registered 16 June 2009.
DOI: 10.1186/s12889-016-3538-3
PMCID: PMC4995663
PMID: 27558630 [Indexed for MEDLINE]
1723. Transl Stroke Res. 2017 Feb;8(1):77-82. doi: 10.1007/s12975-016-0481-7. Epub
2016
Jul 9.
Author information:
(1)Department of Neurology, Stroke Program, University of Michigan, Ann Arbor,
MI, USA. lerusche@umich.edu.
(2)University of Michigan Medical Center, 1500 East Medical Center Drive
SPC#5855, Ann Arbor, MI, 48109-5855, USA. lerusche@umich.edu.
(3)Ann Arbor Department of Veterans Affairs Center for Clinical Management
Research, Ann Arbor, MI, USA.
(4)School of Public Health, University of Michigan, Ann Arbor, MI, USA.
(5)School of Medicine, University of Michigan, Ann Arbor, MI, USA.
(6)Psychiatry, University of Michigan, Ann Arbor, MI, USA.
(7)VA HSR&D Center for Health Information and Communication, Indianapolis, IN,
USA.
(8)Regenstrief Institute, Inc., Indianapolis, IN, USA.
(9)Department of Neurology, Indiana University School of Medicine, Indianapolis,
IN, USA.
(10)Department of Neurology, Stroke Program, University of Michigan, Ann Arbor,
MI, USA.
Automated interactive voice response (IVR) call systems can provide systematic
monitoring and self-management support to depressed patients, but it is unknown
if stroke patients are able and willing to engage in IVR interactions. We sought
to assess the feasibility and acceptability of IVR as an adjunct to post-stroke
depression follow-up care. The CarePartner program is a mobile health program
designed to optimize depression self-management, facilitate social support from a
caregiver, and strengthen connections between stroke survivors and primary care
providers (PCPs). Ischemic stroke patients and an informal caregiver, if
available, were recruited during the patient's acute stroke hospitalization or
follow-up appointment. The CarePartner program was activated in patients with
depressive symptoms during their stroke hospitalization or follow-up. The 3-month
intervention consisted of weekly IVR calls monitoring both depressive symptoms
and medication adherence along with tailored suggestions for depressive symptom
self-management. After each completed IVR call, informal caregivers were
automatically updated, and, if needed, the subject's PCP was notified. Of the 56
stroke patients who enrolled, depressive symptoms were identified in 13 (23 %)
subjects. Subjects completed 74 % of the weekly IVR assessments. A total of six
subjects did not complete the outcome assessment, including two non-study-related
deaths. PCPs were notified five times, including two times for suicidal ideation
and three times for medication non-adherence. Stroke patients with depressive
symptoms were able to engage in an IVR call system. Future studies are needed to
explore the efficacy of an IVR approach for post-stroke self-management and
monitoring of stroke-related outcomes.
DOI: 10.1007/s12975-016-0481-7
PMCID: PMC5507192
PMID: 27394917 [Indexed for MEDLINE]
1724. Iran J Psychiatry. 2017 Apr;12(2):142-146.
Author information:
(1)Department of Clinical Pharmacy, Faculty of Pharmacy, Isfahan University of
Medical Sciences, Isfahan, Iran.
(2)Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of
Medical Sciences, Tehran, Iran.
(3)Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of
Medical Sciences, Tabriz, Iran.
(4)Psychiatry and Psychology Research Center, Roozbeh Hospital and Faculty of
Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
PMCID: PMC5483240
PMID: 28659987
Author information:
(1)Service des Maladies Infectieuses et Réanimation Médicale, Maladies
Infectieuses et Réanimation Médicale, CHU Rennes, 35033, Rennes, France.
arnaud.gacouin@chu-rennes.fr.
(2)Faculté de Médecine, Biosit, Université Rennes 1, 35043, Rennes, France.
arnaud.gacouin@chu-rennes.fr.
(3)Inserm-CIC-1414, Faculté de Médecine, Université Rennes 1, IFR 140, 35033,
Rennes, France. arnaud.gacouin@chu-rennes.fr.
(4)Service des Maladies Infectieuses et Réanimation Médicale, Maladies
Infectieuses et Réanimation Médicale, CHU Rennes, 35033, Rennes, France.
(5)Faculté de Médecine, Biosit, Université Rennes 1, 35043, Rennes, France.
(6)Inserm-CIC-1414, Faculté de Médecine, Université Rennes 1, IFR 140, 35033,
Rennes, France.
(7)Département d'information médicale, CHU Rennes, 35033, Rennes, France.
(8)INSERM, U1099, 35000, Rennes, France.
(9)LTSI, Université de Rennes 1, 35000, Rennes, France.
(10)Département de psychiatrie, Centre Hospitalier Guillaume Regnier, CHU Rennes,
35703, Rennes, France.
DOI: 10.1186/s13613-016-0221-x
PMCID: PMC5209316
PMID: 28050894
1726. Prim Care Companion CNS Disord. 2018 Nov 1;20(6). pii: 18m02340. doi:
10.4088/PCC.18m02340.
Rosenblat JD(1), Simon GE(2)(3), Sachs GS(2), Deetz I(2), Doederlein A(2),
DePeralta D(2), Dean MM(2), McIntyre RS(4)(1)(2).
Author information:
(1)Mood Disorders Psychopharmacology Unit, Toronto Western Hospital, University
Health Network, University of Toronto, Toronto, Ontario, Canada.
(2)Depression and Bipolar Support Alliance, Chicago, Illinois, USA.
(3)Kaiser Permanente Washington Health Research Insitute, Seattle, Washington,
USA.
(4)Mood Disorders Psychopharmacology Unit, University Health Network, University
of Toronto, 399 Bathurst St, MP 9-325, Toronto, ON M5T 2S8, Canada.
roger.mcintyre@uhn.ca.
DOI: 10.4088/PCC.18m02340
PMID: 30444959 [Indexed for MEDLINE]
Author information:
(1)College of Business, University of Puerto Rico, Mayaguez, Puerto Rico.
(2)School of Dental Medicine, Medical Science Campus, University of Puerto Rico,
Medical Science Campus, San Juan, Puerto Rico.
(3)School of Public Health, University of Puerto Rico, Medical Science Campus,
San Juan, Puerto Rico.
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
DOI: 10.1111/jcpe.12553
PMCID: PMC4900929
PMID: 27028763 [Indexed for MEDLINE]
Author information:
(1)Centre Hospitalier J Monod, rue Eugène Garnier BP 219, 61104, Flers cedex.
(2)Université de Caen Basse-Normandie EA 3936, Esplanade de la Paix, BP 5186,
14032, Caen Cedex 05.
(3)INSERM U1086, Cancers et Préventions, Avenue de la Côte de Nacre, F-14000,
Caen.
(4)Centre Régional de Lutte Contre le Cancer François Baclesse, 3 Avenue du
Général Harris, 14000, Caen, France.
DOI: 10.1111/bcp.12734
PMCID: PMC4693496
PMID: 26255807 [Indexed for MEDLINE]
Author information:
(1)Stanford Patient Education Research Center, School of Medicine, Stanford
University, 1000 Welch Road Rd., Suite 204, Palo Alto, CA 94304 USA.
(2)Health Science Center, Texas A&M University, College Station, TX USA.
Depression often accompanies chronic illness. Study aims included determining (1)
the level of current depression (Patient Health Questionnaire (PHQ)-8 ≥ 10) for
two sets of Chronic Disease Self-Management Programs (CDSMP) participants; (2) if
depression or other outcomes improved for those with PHQ-8 ≥ 10; and (3) if
outcomes differed for participants with or without depression. This study
utilized longitudinal secondary data analysis of depression cohorts (PHQ-8 ≥ 10)
from two independent translational implementations of the CDSMP, small-group
(N = 175) and Internet-based (N = 110). At baseline, 27 and 55 % of the two
samples had PHQ-8 10 or greater. This decreased to 16 and 37 % by 12 months
(p < 0.001). Both depressed and non-depressed cohorts demonstrated improvements
in most 12-month outcomes (pain, fatigue, activity limitations, and medication
adherence). The CDSMP was associated with long-term improvements in depression
regardless of delivery mode or location, and the programs appeared beneficial for
participants with and without depression.
DOI: 10.1007/s13142-014-0277-9
PMCID: PMC4286546
PMID: 25584089
Author information:
(1)Xiangya School of Nursing.
(2)Nursing Department, Second Xiangya Hospital, Central South University,
Changsha, Hunan, People's Republic of China.
BACKGROUND: This study assessed the effect of expressed emotion (EE) among
caregivers of schizophrenia patients on their care burden and the illness
rehospitalization rate.
SUBJECTS AND METHODS: A total of 64 schizophrenia patients hospitalized for the
first time and their key caregivers were recruited. The Chinese version of the
Camberwell Family Interview (CFI-CV) was used to evaluate the EE of the key
caregivers. A family burden questionnaire was used to evaluate the care burden.
The patients' rehospitalization rate and medication compliance were evaluated by
the self-designated criteria. The data collection was carried out at the first
meeting in the hospital, at 6 months and 12 months after hospital discharge by
using the same instruments.
RESULTS: The subjective stress burden and subjective demand burden scores were
higher in caregivers before and after discharge with statistical difference
between the various observation time points (P<0.05). Significant differences
were observed in the rehospitalization rate between patients with high medication
adherence and low medication adherence at 12 months (P<0.01) and between patients
with high expressed emotion (HEE) and low expressed emotion (LEE; P<0.05). The
rehospitalization rate in patients with HEE caregivers was higher than that in
those with LEE caregivers. The subjective stress burden scores were statistically
significant between HEE and LEE caregivers (P<0.05).
CONCLUSION: HEE is a predictor of rehospitalization rate in schizophrenic
patients. The burdens of care scores are high in caregivers of schizophrenic
patients. The caregivers with HEE have a high score in burden of care compared
with those with LEE.
DOI: 10.2147/PPA.S143873
PMCID: PMC5593414
PMID: 28919723
The PsyLOG mobile application: development of a tool for the assessment and
monitoring of side effects of psychotropic medication.
Author information:
(1)Department of Psychiatry, Zagreb University Hospital Centre, Kispaticeva 12,
10000 Zagreb, Croatia, mrojnic@gmail.com.
Mobile health interventions are regarded as affordable and accessible tools that
can enhance standard psychiatric care. As part of the mHealth Psycho-Educational
Intervention Versus Antipsychotic-Induced Side Effects (mPIVAS) project
(www.psylog.eu), we developed the mobile application "PsyLOG" based on mobile
"smartphone" technology to monitor antipsychotic-induced side effects. The aim of
this paper is to describe the rationale and development of the PsyLOG and its
clinical use. The PsyLOG application runs on smartphones with Android operating
system. The application is currently available in seven languages (Croatian,
Czech, English, French, German, Japanese and Serbian). It consists of several
categories: "My Drug Effects", "My Life Styles", "My Charts", "My Medication",
"My Strategies", "My Supporters", "Settings" and "About". The main category "My
Drug Effects" includes a list of 30 side effects with the possibility to add
three additional side effects. Side effects are each accompanied by an
appropriate description and the possibility to rate its severity on a visual
analogue scale from 0-100%. The PsyLOG application is intended to enhance the
link between patients and mental health professionals, serving as a tool that
more objectively monitors side-effects over certain periods of time. To the best
of our knowledge, no such applications have so far been developed for patients
taking antipsychotic medication or for their therapists.
PMID: 28636581 [Indexed for MEDLINE]
1732. J Chiropr Educ. 2016 Mar;30(1):25-9. doi: 10.7899/JCE-15-2. Epub 2015 Aug 4.
OBJECTIVE: Free or outreach clinics offer students the opportunity to work with
diverse patient populations. The objective of this study was to describe the
demographics and clinical characteristics of a sample of chiropractic patients at
a free community-based clinic to assess clinical and educational opportunities
for students to work with diverse populations, collaborate with other professions
and practice health promotion through patient education.
METHODS: This was a prospective, descriptive cross-sectional study conducted over
2 months. Data on demographics, health status, and health risks were collected
from patients and their interns.
RESULTS: Of the 158 patients, 50.6% were women and 50.6% African-American, while
only 20.9% were employed full-time. Of the 24.7% tobacco users, 48.7% expressed
interest in cessation. Of 80.0% overweight or obese patients, 48.8% expressed
interest in weight loss. By self-report, 16.5% were diabetic, 10.1% took
hypertension medication, 36.7% used prescription pain medication (9.4% opiate
use), 33.5% used nonprescription pain medication, and 9.4% were under the care of
a mental health professional.
CONCLUSION: This patient population is demographically diverse. A high proportion
of patients who used tobacco, or were overweight or obese expressed interest in
information on those topics. A substantial proportion reported being under care
with a mental health professional. This clinic provides opportunities for
students to work with diverse populations, collaborate with other professions,
and practice health promotion.
DOI: 10.7899/JCE-15-2
PMCID: PMC4770992
PMID: 26241702
Author information:
(1)Departments of *Medicine, Division of Gastroenterology and Hepatology
†Medicine ‡Biostatistics, Gillings School of Public Health §Division of General
Medicine and Clinical Epidemiology, University of North Carolina, Chapel Hill,
NC.
DOI: 10.1097/MCG.0000000000000055
PMCID: PMC4062612
PMID: 24356458 [Indexed for MEDLINE]
1734. Nicotine Tob Res. 2016 May;18(5):906-12. doi: 10.1093/ntr/ntv205. Epub 2015
Sep
21.
Bowker K(1), Campbell KA(2), Coleman T(2), Lewis S(3), Naughton F(4), Cooper
S(2).
Author information:
(1)Division of Primary Care, University of Nottingham, Nottingham, United
Kingdom; Katharine.bowker@nottingham.ac.uk.
(2)Division of Primary Care, University of Nottingham, Nottingham, United
Kingdom;
(3)Division of Epidemiology and Public Health, Nottingham City Hospital,
Nottingham, United Kingdom;
(4)Behavioural Science Group, Institute of Public Health, University of
Cambridge, Cambridge, United Kingdom.
© The Author 2015. Published by Oxford University Press on behalf of the Society
for Research on Nicotine and Tobacco. All rights reserved. For permissions,
please e-mail: journals.permissions@oup.com.
DOI: 10.1093/ntr/ntv205
PMCID: PMC5942617
PMID: 26391578 [Indexed for MEDLINE]
Farah R(1)(2), Zeidan RK(3), Chahine MN(4), Asmar R(4), Chahine R(5), Salameh
P(6)(7), Pathak A(8), Hosseini H(9)(10).
Author information:
(1)Doctoral School of Life and Health Sciences, Paris-Est University, Creteil,
France. rita.farah@univ-paris-est.fr.
(2)EA 4391, Excitabilité Nerveuse et Thérapeutique, Université Paris-Est,
Creteil, France. rita.farah@univ-paris-est.fr.
(3)Doctoral School of Biology Health and Biotechnologies, Toulouse III
University, Toulouse, France.
(4)Foundation-Medical Research Institutes, F-MRI®, Beirut, Lebanon.
(5)Faculty of Medical Sciences, Lebanese University, Hadath, Lebanon.
(6)School of Pharmacy, Lebanese American University, Byblos, Lebanon.
(7)Laboratory of Clinical and Epidemiology Research, Faculty of Pharmacy,
Lebanese University, Hadath, Lebanon.
(8)Department of Cardiovascular Medicine, Hypertension, Risk Factors and Heart
Failure Unit, Clinique Pasteur, Toulouse, France.
(9)EA 4391, Excitabilité Nerveuse et Thérapeutique, Université Paris-Est,
Creteil, France.
(10)Department of Neurology, Henri Mondor Hospital AP-HP, Creteil, France.
DOI: 10.1111/jch.12775
PMID: 26801001 [Indexed for MEDLINE]
Author information:
(1)Department of Medicine, The University of Chicago, Chicago, IL.
(2)Harris School of Public Policy, The University of Chicago, Chicago, IL.
(3)Department of Economics, The University of Chicago, Chicago, IL.
DOI: 10.21767/2471-9927.100040
PMCID: PMC6322665
PMID: 30627691
Author information:
(1)Department of Internal Medicine, New Mexico VA Health Care Service, 1501 San
Pedro Ave, SE, Albuquerque, NM, 87108, USA. wgerstein@gmail.com.
(2)Department of Internal Medicine Residency Program, University of New Mexico, 1
University of New Mexico, Albuquerque, NM, 87131-0001, USA.
DOI: 10.1186/s12877-017-0567-4
PMCID: PMC5534102
PMID: 28754091 [Indexed for MEDLINE]
Author information:
(1)Department of Medicine, Tulane University School of Medicine, 1430 Tulane
Avenue, New Orleans, LA 70112, USA.
(2)Department of Medicine, Tulane University School of Medicine, 1430 Tulane
Avenue, New Orleans, LA 70112, USA; Department of Epidemiology, Tulane University
School of Public Health and Tropical Medicine, 1440 Canal Street, New Orleans, LA
70112, USA; Center for Health Research, Ochsner Clinic Foundation, 1514 Jefferson
Highway, New Orleans, LA 70121, USA. Electronic address: mawood@tulane.edu.
DOI: 10.1016/j.mcna.2016.08.005
PMCID: PMC5156530
PMID: 27884232 [Indexed for MEDLINE]
Dong Y(1), Wang P(2), Dai Z(1), Liu K(1), Jin Y(1), Li A(1), Wang S(1), Zheng
J(1).
Author information:
(1)Department of Orthopedics, Henan Provincial People's Hospital, Zhengzhou,
Henan.
(2)Department of Internal Medicine, The Second Affiliated Hospital of Hainan
Medical University, Hainan Medical University, Haikou, Hainan, China.
DOI: 10.1097/MD.0000000000013632
PMCID: PMC6319995
PMID: 30558051 [Indexed for MEDLINE]
Rohan JM(1), Drotar D(2), Alderfer M(3), Donewar CW(3), Ewing L(3), Katz ER(3),
Muriel A(3).
Author information:
(1)Department of Psychology, University of Cincinnati, USA, Center for Adherence
and Self-Management, Cincinnati Children's Hospital Medical Center, USA, The
Cancer Center, Children's Hospital of Philadelphia, USA, Department of
Psychiatry, Children's Hospital Medical Center, USA, Department of Psychiatry,
Western Psychiatric Institute and Clinic, USA, Division of Hematology-Oncology
and Blood & Marrow Transplant, Children's Hospital Los Angeles, USA, and
Adolescent Psychiatry & Pediatric Psychiatry, Dana-Farber/Children's Hospital
Cancer Center, USA Department of Psychology, University of Cincinnati, USA,
Center for Adherence and Self-Management, Cincinnati Children's Hospital Medical
Center, USA, The Cancer Center, Children's Hospital of Philadelphia, USA,
Department of Psychiatry, Children's Hospital Medical Center, USA, Department of
Psychiatry, Western Psychiatric Institute and Clinic, USA, Division of
Hematology-Oncology and Blood & Marrow Transplant, Children's Hospital Los
Angeles, USA, and Adolescent Psychiatry & Pediatric Psychiatry,
Dana-Farber/Children's Hospital Cancer Center, USA rohanjenm@gmail.com.
(2)Department of Psychology, University of Cincinnati, USA, Center for Adherence
and Self-Management, Cincinnati Children's Hospital Medical Center, USA, The
Cancer Center, Children's Hospital of Philadelphia, USA, Department of
Psychiatry, Children's Hospital Medical Center, USA, Department of Psychiatry,
Western Psychiatric Institute and Clinic, USA, Division of Hematology-Oncology
and Blood & Marrow Transplant, Children's Hospital Los Angeles, USA, and
Adolescent Psychiatry & Pediatric Psychiatry, Dana-Farber/Children's Hospital
Cancer Center, USA Department of Psychology, University of Cincinnati, USA,
Center for Adherence and Self-Management, Cincinnati Children's Hospital Medical
Center, USA, The Cancer Center, Children's Hospital of Philadelphia, USA,
Department of Psychiatry, Children's Hospital Medical Center, USA, Department of
Psychiatry, Western Psychiatric Institute and Clinic, USA, Division of
Hematology-Oncology and Blood & Marrow Transplant, Children's Hospital Los
Angeles, USA, and Adolescent Psychiatry & Pediatric Psychiatry,
Dana-Farber/Children's Hospital Cancer Center, USA.
(3)Department of Psychology, University of Cincinnati, USA, Center for Adherence
and Self-Management, Cincinnati Children's Hospital Medical Center, USA, The
Cancer Center, Children's Hospital of Philadelphia, USA, Department of
Psychiatry, Children's Hospital Medical Center, USA, Department of Psychiatry,
Western Psychiatric Institute and Clinic, USA, Division of Hematology-Oncology
and Blood & Marrow Transplant, Children's Hospital Los Angeles, USA, and
Adolescent Psychiatry & Pediatric Psychiatry, Dana-Farber/Children's Hospital
Cancer Center, USA.
© The Author 2013. Published by Oxford University Press on behalf of the Society
of Pediatric Psychology. All rights reserved. For permissions, please e-mail:
journals.permissions@oup.com.
DOI: 10.1093/jpepsy/jst093
PMCID: PMC4288299
PMID: 24365698 [Indexed for MEDLINE]
Surur AS(1), Getachew E(2), Teressa E(3), Hailemeskel B(4), Getaw NS(5), Erku
DA(6).
Author information:
(1)BPharm, MSc. Assistant Professor. Department of Pharmaceutical Chemistry,
School of Pharmacy, College of Medicine and Health Sciences, University of
Gondar. Gondar (Ethiopia). lowerurexpect@gmail.com.
(2)BPharm. Assistant Lecturer. Department of Pharmacology, School of Pharmacy,
College of Medicine and Health Sciences, University of Gondar. Gondar (Ethiopia).
eyobagetachew12@gmail.com.
(3)BPharm. Assistant Lecturer. Department of clinical pharmacy, School of
Pharmacy, College of Medicine and Health Sciences, University of Gondar. Gondar
(Ethiopia). ebsateressa@gmail.com.
(4)MS, PharmD, RPh. Associate Professor and Director of Drug Information
Services. School of Pharmacy, College of Pharmacy, Nursing, and Allied Health
Sciences, Howard University. Washington, DC (United States).
bhailemeskel@howard.edu.
(5)BPharm, MSc. Senior Lecturer. Department of Pharmaceutical Chemistry, School
of Pharmacy, College of Medicine and Health Sciences, University of Gondar.
Gondar (Ethiopia). nurahmeds10@gmail.com.
(6)B.Pharm. Lecturer. Department of Pharmacy Practice, School of Pharmacy,
College of Medicine and Health Sciences, University of Gondar. Gondar (Ethiopia).
staymotivated015@gmail.com.
DOI: 10.18549/PharmPract.2017.01.890
PMCID: PMC5386626
PMID: 28503225
1742. BMC Health Serv Res. 2018 Apr 6;18(1):254. doi: 10.1186/s12913-018-3071-4.
Ratanawongsa N(1), Quan J(2), Handley MA(2)(3), Sarkar U(2), Schillinger D(2).
Author information:
(1)General Internal Medicine and UCSF Center for Vulnerable Populations at San
Francisco General Hospital and Trauma Center, University of California, 1001
Potrero Avenue, Box 1364, San Francisco, CA, 94143, USA.
Neda.ratanawongsa@ucsf.edu.
(2)General Internal Medicine and UCSF Center for Vulnerable Populations at San
Francisco General Hospital and Trauma Center, University of California, 1001
Potrero Avenue, Box 1364, San Francisco, CA, 94143, USA.
(3)Department of Epidemiology and Biostatistics, Division of Preventive Medicine
and Public Health, University of California, 1001 Potrero Avenue, Box 1364, San
Francisco, CA, 94143, USA.
DOI: 10.1186/s12913-018-3071-4
PMCID: PMC5889590
PMID: 29625571 [Indexed for MEDLINE]
Davis S(1).
Author information:
(1)Faculty of Pharmacy and Woolcock Institute of Medical Research, University of
Sydney, Sydney, New South Wales, Australia.
People with intellectual disability are a vulnerable group of people with asthma
that has, to date, largely been ignored in the medical literature. Although
guidelines for medication management for people with intellectual disability
suggest asthma is treated as for other populations, there are special
considerations that should be taken into account when managing asthma in this
group. Due to their cognitive impairment as well as comorbidities, they are
likely to require support with asthma self-management, including inhaler use.
Their varying degrees of autonomy mean that there is often a need to provide
education and information to both the person and their caregivers.EDUCATIONAL
AIMS: To understand general principles of health of people with intellectual
disability and how this affects the healthcare professional's approach to asthma
management.To understand how intellectual disability affects cognition, autonomy
and communication, and therefore the ability of a person to self-manage asthma.To
recognise ways of mitigating respiratory disease risk in people with intellectual
disability.To describe ways for healthcare professionals to support people with
intellectual disability and their caregivers in asthma management.
DOI: 10.1183/20734735.014716
PMCID: PMC5297950
PMID: 28210318
Richardson A(1), Tolley E(2), Hartmann J(3), Reedus J(3), Bowlin B(3), Finch
C(4), Sands CW(5), Self T(4).
Author information:
(1)Department of Pharmacy, Methodist University Hospital, Memphis, TN, USA;
College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN,
USA. Electronic address: arichardson@chsu.org.
(2)Department of Preventive Medicine, University of Tennessee Health Science
Center, Memphis, TN, USA.
(3)Department of Pharmacy, Methodist University Hospital, Memphis, TN, USA.
(4)Department of Pharmacy, Methodist University Hospital, Memphis, TN, USA;
College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN,
USA.
(5)College of Medicine, University of Tennessee Health Science Center, Memphis,
TN, USA; Hospitalist, Methodist University Hospital, Memphis, TN, USA.
Erratum for
Respir Med. 2016 Oct;119:135-140.
DOI: 10.1016/j.rmed.2016.11.013
PMID: 27916482
Author information:
(1)Centre for Genomics and Child Health, Queen Mary University of London, London,
UK.
DOI: 10.1136/bmjopen-2018-025867
PMCID: PMC6500249
PMID: 31015270
Author information:
(1)Stanford University.
(2)University of Southern California.
Most individuals who develop Major Depressive Disorder (MDD) will experience a
recurrent depressive episode; we know little, however, about cognitive mechanisms
that increase the likelihood of recurrence. In the current study we examined
whether negatively biased self-referential processing, negative life events,
baseline depressive symptoms, and psychotropic medication use predicted the onset
of a subsequent depressive episode in a longitudinal study of women with a
history of recurrent MDD. Higher levels of depressive symptoms at baseline
predicted experiencing a greater number of negative life events which, in turn,
tended to predict recurrence of depression. Importantly, after accounting for
other associations, negatively biased self-referential processing contributed
unique variance to the likelihood of experiencing a depressive episode over the
next three years. Thus, negatively biased self-referential processing appears to
be a significant risk factor for the recurrence of depressive episodes and may be
an important target for interventions aimed at preventing future episodes.
DOI: 10.1177/2167702616654898
PMCID: PMC5341388
PMID: 28286705
Author information:
(1)GKT School of Medicine, King's College London, London, SE1 1UL, UK.
(2)Institute of Psychiatry, Psychology & Neuroscience, Academic Neuroscience
Centre, King's College London, PO Box 57, London, SE5 8AF, UK.
(3)Institute of Psychiatry, Psychology & Neuroscience, Academic Neuroscience
Centre, King's College London, PO Box 57, London, SE5 8AF, UK.
leone.ridsdale@kcl.ac.uk.
DOI: 10.1186/s12883-017-0893-3
PMCID: PMC5474294
PMID: 28623909 [Indexed for MEDLINE]
As people living with HIV age, they face increasing self-management work related
to HIV infection plus the prevention and mitigation of multiple chronic health
conditions, including daily health practices (i.e., physical activity,
nutrition), engaging in a supportive community, and accepting the chronicity of
HIV. Our purpose was to describe the relationship between HIV self-management
practices and mental wellness (depressive symptoms, perceived stress).
Ninety-three adult people living with HIV on antiretroviral therapy were enrolled
and completed a survey. We used descriptive statistics to summarize variables,
and Spearman rank correlation and quantile regression to study associations
between variables. Participants' average age was 48.6 years, 56% were male, and
87% were African American. Daily self-management practices were associated with
depressive symptoms (r = -0.19; p ≤ .01) and perceived stress (r = -0.14;
p = .06); engaging with a supportive community and accepting the chronicity of
HIV were not associated with mental wellness (all p > .05).
DOI: 10.1016/j.jana.2016.03.002
PMCID: PMC4903919
PMID: 27066751 [Indexed for MEDLINE]
1749. Acta Paediatr. 2019 Feb;108(2):333-338. doi: 10.1111/apa.14471. Epub 2018 Jul
10.
Self-efficacy did not predict the outcome of the transition to adult care
in adolescents with inflammatory bowel disease.
van den Brink G(1), van Gaalen MAC(1), Zijlstra M(2), de Ridder L(1), van der
Woude CJ(3), Escher JC(1).
Author information:
(1)Department of Paediatric Gastroenterology, Erasmus MC-Sophia Children's
Hospital, Rotterdam, The Netherlands.
(2)Department of Paediatric Gastroenterology, Wilhelmina Children's Hospital,
University Medical Center Utrecht, Utrecht, The Netherlands.
(3)Department of Gastroenterology, Erasmus MC, Rotterdam, The Netherlands.
AIM: It can be difficult for adolescents with inflammatory bowel disease (IBD) to
make the transition from paediatric to adult care. We studied the outcomes of
this process and defined what constituted a successful transition.
METHODS: In 2008, 50 adolescents who attended our IBD transition clinic completed
IBD-yourself, a self-efficacy questionnaire that we had previously developed and
validated. We approached the subjects in 2014, two to six years after they
transferred to adult care, and 35 agreed to take part in the current study. The
outcome of transition was assessed by our newly developed Transition Yourself
Score. In addition, the relationship between self-efficacy and the outcome of the
transition was measured.
RESULTS: The mean age of the patients was 21.8 years, and 69% suffered from
Crohn's disease. The transition process was successful in 63% of cases,
moderately successful in 31% and failed in 6%. A successful transition was
associated with effective use of medication and clinical remission at the time of
transfer, but could not be predicted by self-efficacy. The Transition Yourself
Score will be validated in future studies.
CONCLUSION: Nearly two-thirds (63%) of the adolescents who attended the IBD
transition clinic had a successful transition to adult care.
©2018 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf
of Foundation Acta Paediatrica.
DOI: 10.1111/apa.14471
PMCID: PMC6585705
PMID: 29926962
Author information:
(1)C/O Gastroenterology Department, Royal Alexandra and Vale of Leven Hospitals,
Paisley, UK.
DOI: 10.1136/flgastro-2017-100807
PMCID: PMC5641849
PMID: 29067153
Author information:
(1)Institute of Chronic Diseases Control and Prevention, Beijing Center for
Diseases Control and Prevention, Beijing, China.
(2)Lab of Exercise Epidemiology, Graduate School of Sport Sciences, Waseda
University, Saitama, Japan.
OBJECTIVES: This study aimed to compare hypertension trends in the urban and
suburban population, and to examine the use of several self-care behaviors among
patients who were aware of their hypertension.
METHODS: We examined the data from three cross-sectional adult populations
obtained in 2005, 2008, and 2011, in Beijing.
RESULTS: Our analyses indicated that from 2005 to 2011 the standardized rate of
hypertension increased from 31.9% to 36.0% (P <0.001) among urban adults, and was
relatively stable (40.8% -40.2%) among suburban adults (P = 0.02). About 10% of
the patients reported having taken measures to control their weight for
hypertension management. As compared to the other patients, the female patients
in the urban areas reported the highest rate of regular BP measurement (52.6%).
In addition, the patients who reported taking medication regularly increased
among the males and females. Most of the women reported nonsmoking (≥95%) and
alcohol abstinence (≥90%). The trend of nonsmoking decreased among the urban
males. In contrast, the prevalence of nonsmoking increased among the suburban
males, though the trend was not statistically significant (P = 0.055). Further,
the patient-reported alcohol abstinence was found to exhibit a decreasing trend
among the males.
CONCLUSIONS: We observed an increase in the hypertension prevalence from 2005 to
2011. The rates remained higher for suburban adults than for urban adults.
Females generally had better self-care ability as compared to male patients.
Further research is needed to promote self-care behaviors in hypertensive
patients, especially for male patients.
DOI: 10.1371/journal.pone.0117999
PMCID: PMC4322055
PMID: 25665069 [Indexed for MEDLINE]
Author information:
(1)Department of Midwifery, College of Health Science, KTO Karatay University,
Konya, Turkey.
(2)Department of Midwifery, College of Health Science, Bozok University, Yozgat,
Turkey.
(3)Department of Midwifery, Faculty of Health Science, Eskişehir Osmangazi
University, Eskişehir, Turkey.
DOI: 10.5114/pm.2019.84152
PMCID: PMC6528038
PMID: 31114453
1753. Eur Respir J. 2018 Jan 31;51(2). pii: 1701509. doi: 10.1183/13993003.01509-
2017.
Print 2018 Feb.
First trimester fetal size and prescribed asthma medication at 15 years of age.
Author information:
(1)Child Health, University of Aberdeen, Aberdeen, UK s.w.turner@abdn.ac.uk.
(2)Medical Statistics Team, Institute of Applied Health Sciences, University of
Aberdeen, Aberdeen, UK.
(3)Child Health, University of Aberdeen, Aberdeen, UK.
DOI: 10.1183/13993003.01509-2017
PMID: 29386348 [Indexed for MEDLINE]
Author information:
(1)Programa de Pós-Graduação em Enfermagem, Universidade Federal do Piauí,
Teresina, PI, Brasil.
(2)Programa de Pós-Graduação em Ciências e Saúde, Universidade Federal do Piauí,
Picos, PI, Brasil.
DOI: 10.1590/0034-7167.2015680115p
PMID: 25946502 [Indexed for MEDLINE]
Author information:
(1)*Department of Neurology, David Geffen School of Medicine at the University of
California Los Angeles, Los Angeles, CA; †Department of Psychiatry, Rush
University Medical Center, Chicago, IL; ‡Department of Neurology, Johns Hopkins
University School of Medicine, Baltimore, MD; §Departments of Psychiatry and
Neurology, Johns Hopkins University School of Medicine, Baltimore, MD; and
‖Departments of Psychiatry and Neurology, University of Pittsburgh, Pittsburgh,
PA.
DOI: 10.1097/QAI.0000000000001371
PMCID: PMC5429190
PMID: 28328547 [Indexed for MEDLINE]
1756. AIDS Behav. 2015 Jan;19(1):128-36. doi: 10.1007/s10461-014-0850-8.
White BL(1), Golin CE, Grodensky CA, Kiziah CN, Richardson A, Hudgens MG, Wohl
DA, Kaplan AH.
Author information:
(1)Department of Medicine, School of Medicine, University of North Carolina
School of Medicine, 130 Mason Farm Road, Chapel Hill, NC, 27284, USA,
bls@med.unc.edu.
DOI: 10.1007/s10461-014-0850-8
PMCID: PMC4303492
PMID: 25055766 [Indexed for MEDLINE]
Author information:
(1)Psychological Sciences, University of Liverpool, Liverpool, United Kingdom;
Nidaros DPS, Division of Psychiatry, St. Olavs University Hospital, Trondheim,
Norway. Electronic address: peter.fisher@liverpool.ac.uk.
(2)Psychological Sciences, University of Liverpool, Liverpool, United Kingdom.
DOI: 10.1016/j.seizure.2017.06.012
PMID: 28667910 [Indexed for MEDLINE]
How can we help family carers manage pain medicines for patients with advanced
cancer? A systematic review of intervention studies.
Latter S(1), Hopkinson JB(2), Richardson A(3), Hughes JA(1), Lowson E(1), Edwards
D(2).
Author information:
(1)Faculty of Health Sciences, University of Southampton, Southampton, UK.
(2)School of Healthcare Sciences, Cardiff University, Cardiff, Wales, UK.
(3)Faculty of Health Sciences, University of Southampton, Southampton, UK
Department of Cancer Care, University Hospital Southampton NHS Foundation Trust,
Southampton, UK.
BACKGROUND: Family carers play a significant role in managing pain and associated
medicines for people with advanced cancer. Research indicates that carers often
feel inadequately prepared for the tasks involved, which may impact on carers'
and patients' emotional state as well as the achievement of optimal pain control.
However, little is known about effective methods of supporting family carers with
cancer pain medicines.
AIMS: To systematically identify and review studies of interventions to help
carers manage medicines for pain in advanced cancer. To identify implications for
practice and research.
METHOD: A systematic literature search of databases (MEDLINE, CINAHL, PsycINFO
and AMED) was carried out to identify studies of pain medication management
interventions that involved family carers of patients with advanced cancer, and
reported specific outcomes for family carers. Patient pain outcomes were also
sought. Studies were quality appraised; key aspects of study design,
interventions and outcomes were compared and a narrative synthesis of findings
developed.
RESULTS: 8 studies were included; all had significant methodological limitations.
The majority reported improvements in family carer knowledge and/or self-efficacy
for managing pain medicines; no effect on patient pain outcomes; and no adverse
effects. It was not possible to discern any association between particular
intervention characteristics and family carer outcomes.
CONCLUSIONS: Current evidence is limited, but overall suggests face-to-face
educational interventions supported by written and/or other resources have
potential to improve carers' knowledge and self-efficacy for pain management.
Further research is needed to identify how best to help family carers manage pain
medicines for patients with advanced cancer.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://www.bmj.com/company/products-services/rights-and-licensing/
DOI: 10.1136/bmjspcare-2015-000958
PMCID: PMC5013162
PMID: 27150294 [Indexed for MEDLINE]
Author information:
(1)Clinical Psychology, University of Graz, BioTechMed, Graz, Austria. Electronic
address: Anne.schienle@uni-graz.at.
(2)Clinical Psychology, University of Graz, BioTechMed, Graz, Austria.
Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights
reserved.
DOI: 10.1016/j.neulet.2015.10.046
PMCID: PMC4681091
PMID: 26497912 [Indexed for MEDLINE]
Author information:
(1)University of Tennessee Health Science Center, Memphis, TN, USA.
(2)Texas Tech University Health Sciences Center, Abilene, TX, USA.
Taylor CL(1), Broadbent M(2), Khondoker M(3), Stewart RJ(4), Howard LM(5).
Author information:
(1)Section of Women's Mental Health, Health Service and Population Research
Department, Institute of Psychiatry, King's College London, UK. Electronic
address: clare.l.taylor@kcl.ac.uk.
(2)South London and Maudsley NHS Foundation Trust, London, UK. Electronic
address: matthew.broadbent@kcl.ac.uk.
(3)University of East Anglia, Norwich Medical School, Norwich Research Park,
Norwich, UK. Electronic address: m.khondoker@uea.ac.uk.
(4)Psychological Medicine Department, Institute of Psychiatry, King's College
London, UK; South London and Maudsley NHS Foundation Trust, London, UK.
Electronic address: robert.stewart@kcl.ac.uk.
(5)Section of Women's Mental Health, Health Service and Population Research
Department, Institute of Psychiatry, King's College London, UK; South London and
Maudsley NHS Foundation Trust, London, UK. Electronic address:
louise.howard@kcl.ac.uk.
Pregnancy in women with severe mental illness is associated with adverse outcomes
for mother and infant. There are limited data on prevalence and predictors of
relapse in pregnancy. A historical cohort study using anonymised comprehensive
electronic health records from secondary mental health care linked with national
maternity data was carried out. Women with a history of serious mental illness
who were pregnant (2007-2011), and in remission at the start of pregnancy, were
studied; severe relapse was defined as admission to acute care or self-harm.
Predictors of relapse were analysed using random effects logistic regression to
account for repeated measures in women with more than one pregnancy in the study
period. In 454 pregnancies (389 women) there were 58 (24%) relapses in women with
non-affective psychoses and 25 (12%) in women with affective psychotic or bipolar
disorders. Independent predictors of relapse included non-affective psychosis
(adjusted OR = 2.03; 95% CI = 1.16-3.54), number of recent admissions (1.37;
1.03-1.84), recent self-harm (2.24; 1.15-4.34), substance use (2.15; 1.13-4.08),
smoking (2.52; 1.26-5.02) and non-white ethnicity (black ethnicity: 2.37;
1.23-4.57, mixed/other ethnicity: 2.94; 1.32-6.56). Women on no regular
medication throughout first trimester were also at greater risk of relapse in
pregnancy (1.99; 1.05-3.75). There was no interaction between severity of illness
and medication status as relapse predictors. Therefore, women with non-affective
psychosis and higher number of recent acute admissions are at significant risk of
severe relapse in pregnancy. Continuation of medication in women with severe
mental illness who become pregnant may be protective.
Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.jpsychires.2018.06.019
PMID: 30015264
Pladevall M(1)(2), Divine G(3), Wells KE(3), Resnicow K(4), Williams LK(1)(5).
Author information:
(1)Center for Health Policy and Health Services Research, Henry Ford Health
System, Detroit, Michigan (Dr Pladevall, Dr Williams)
(2)Research Triangle Institute Health Solutions, Barcelona, Spain (Dr Pladevall)
(3)Department of Public Health Sciences, Henry Ford Health System, Detroit,
Michigan (Dr Divine, Ms Wells)
(4)Center for Health Communications Research, University of Michigan, Ann Arbor,
Michigan (Dr Resnicow)
(5)Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan
(Dr Williams)
Comment in
Diabetes Educ. 2015 Oct;41(5):625-6.
PURPOSE: The purpose of this study was to assess whether providing medication
adherence information with or without motivational interviewing improves diabetes
and lipid control.
METHODS: Study participants were adult members of a health system in southeast
Michigan, were using both oral diabetes and lipid-lowering medications, and had
glycated hemoglobin (A1C) or low-density lipoprotein cholesterol (LDL-C) levels
not at goal. Participants were randomly assigned to receive usual care (UC), n =
567; have medication adherence information (AI) provided to their physician, n =
569; or have AI and receive motivational interviewing (MI) though trained staff
(AI + MI), n = 556. Primary outcomes were A1C and LDL-C levels at 18 months post
randomization.
RESULTS: Primary outcomes were not significantly different between patients in
the AI or AI + MI study arms when compared with UC. Similarly, neither oral
diabetes nor lipid-lowering medication adherence was significantly different
between groups. Patient participation in the AI + MI arm was low and limit the
interpretation of the study results, but post hoc analysis of the AI + MI study
arm showed that the number of MI sessions received was positively associated with
only oral diabetes medication adherence.
CONCLUSION: Neither AI nor MI significantly improved diabetes and lipid control
when compared with UC. Moreover, patient participation appeared to be a
particular barrier for MI.
DOI: 10.1177/0145721714561031
PMCID: PMC4722813
PMID: 25486932 [Indexed for MEDLINE]
1763. Nicotine Tob Res. 2014 Nov;16(11):1463-9. doi: 10.1093/ntr/ntu099. Epub 2014
Jun
20.
Author information:
(1)Department of Health Disparities Research, University of Texas MD Anderson
Cancer Center, Houston, TX; made@mdanderson.org.
(2)Butler Hospital, Providence, RI;
(3)Butler Hospital, Providence, RI; Department of Medicine, Warren Alpert Medical
School, Brown University, Providence, RI; Department of Health Services, Policy,
and Practice, Warren Alpert Medical School, Brown University, Providence, RI.
© The Author 2014. Published by Oxford University Press on behalf of the Society
for Research on Nicotine and Tobacco. All rights reserved. For permissions,
please e-mail: journals.permissions@oup.com.
DOI: 10.1093/ntr/ntu099
PMCID: PMC4271088
PMID: 24951495 [Indexed for MEDLINE]
Leke AZ(1)(2), Dolk H(3), Loane M(3), Casson K(3), Maboh NM(4), Maeya SE(4),
Ndumbe LD(4), Nyenti PB(4), Armstrong O(4), Etiendem D(4).
Author information:
(1)Department of Nursing, School of Health Sciences, Biaka University Institute
of Buea-Cameroon, PO BOX 77, Buea, Cameroon. zawuol@gmail.com.
(2)Office of the Deputy Vice Chancellor i/c Research/Cooperation/Quality, Biaka
Universit Institute of Buea, PO Box 77-SWR, Buea, Cameroon. zawuol@gmail.com.
(3)Centre for Maternal, Fetal and Infant Research, Institute for Nursing and
Health Research, Ulster University, Shore Rd Newtownabbey, BT370QB, Ulster,
Ireland.
(4)Department of Nursing, School of Health Sciences, Biaka University Institute
of Buea-Cameroon, PO BOX 77, Buea, Cameroon.
DOI: 10.1186/s12884-018-2081-x
PMCID: PMC6245902
PMID: 30458752 [Indexed for MEDLINE]
Fleisher JE(1), Dahodwala NA(2), Xie SX(3), Mayo M(2), Weintraub D(2), Chodosh
J(4), Shea JA(5).
Author information:
(1)The Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders,
New York University School of Medicine, Departments of Neurology and Population
Health, New York, NY, USA.
(2)University of Pennsylvania Perelman School of Medicine, Department of
Neurology, Philadelphia, PA, USA.
(3)University of Pennsylvania Perelman School of Medicine, Department of
Biostatistics and Epidemiology., Philadelphia, PA, USA.
(4)New York University School of Medicine, Division of Geriatric Medicine and
Palliative Care, Department of Medicine, New York, NY, USA.
(5)University of Pennsylvania Perelman School of Medicine, Department of
Medicine, Philadelphia, PA, USA.
DOI: 10.3233/JPD-150765
PMCID: PMC4884139
PMID: 27061070 [Indexed for MEDLINE]
1766. Respir Care. 2014 Nov;59(11):1731-46. doi: 10.4187/respcare.02990. Epub 2014
Jul
15.
Author information:
(1)School of Public Health, Physiotherapy and Population Science, Health Science
Centre, University College Dublin, Dublin, Ireland.
(2)School of Public Health, Physiotherapy and Population Science, Health Science
Centre, University College Dublin, Dublin, Ireland. brona.fullen@ucd.ie.
DOI: 10.4187/respcare.02990
PMID: 25233386 [Indexed for MEDLINE]
Author information:
(1)Charles R. Drew University of Medicine and Science, 1731 East 120th Street,
Los Angeles, CA, 90005, USA. mobazarg@cdrewu.edu.
(2)University of California, Los Angeles, USA. mobazarg@cdrewu.edu.
(3)Charles R. Drew University of Medicine and Science, 1731 East 120th Street,
Los Angeles, CA, 90005, USA.
(4)University of California, Los Angeles, USA.
DOI: 10.1186/s12877-018-0926-9
PMCID: PMC6173851
PMID: 30290768 [Indexed for MEDLINE]
Author information:
(1)Department of Veterans Affairs, Community Health Systems, University of
California, San Francisco, San Francisco, CA, United States.
(2)Edward Hines Jr., VA Hospital, Department of Biobehavioral Health Science,
University of Illinois at Chicago, Chicago, IL, United States.
(3)University of California, San Francisco, Social and Behavioral Sciences, San
Francisco, CA, United States.
(4)Department of Veterans Affairs, Department of Medicine, Epidemiology and
Biostatistics, University of California, San Francisco, San Francisco, CA, United
States.
DOI: 10.2196/resprot.7327
PMCID: PMC5539386
PMID: 28720557
How many instructions are required to correct inhalation errors in patients with
asthma and chronic obstructive pulmonary disease?
Takaku Y(1), Kurashima K(2), Ohta C(2), Ishiguro T(2), Kagiyama N(2), Yanagisawa
T(2), Takayanagi N(2).
Author information:
(1)Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory
Center, Itai, 1696, Kumagaya city, Saitama, Japan. Electronic address:
takaku.yotaro@pref.saitama.lg.jp.
(2)Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory
Center, Itai, 1696, Kumagaya city, Saitama, Japan.
DOI: 10.1016/j.rmed.2016.12.012
PMID: 28137486 [Indexed for MEDLINE]
1770. Asian Nurs Res (Korean Soc Nurs Sci). 2014 Dec;8(4):274-81. doi:
10.1016/j.anr.2014.10.001. Epub 2014 Oct 28.
Author information:
(1)Department of Nursing, Dankook University, Chungnam, South Korea.
(2)Department of Nursing, Dankook University, Chungnam, South Korea. Electronic
address: jinjoo@dankook.ac.kr.
PURPOSE: This study was to evaluate effects of case management provided for 7
months for medical aid in Korea.
METHODS: This study was a retrospective comparative study using secondary data
analysis. Data from two pre-existing survey were reanalyzed. The data were
collected through door to-door interviews using the structured questionnaire. For
the medical service use, claims data from the Korea National Health Insurance
Corporation was used. Subjects were 73 in the intervention group and 118 in the
control group.
RESULTS: There was no significant change in the intervention group in self-care
ability (p = .296), medication adherence (p = .194) or quality of life (p = .903)
compared to those of the control group. For hospital visiting days, it appeared
to decrease in the intervention group (p = .038) but with no significant
difference from that of the control group (p = .157). Neither were there
significant differences in medical expenditures (p = .605).
CONCLUSION: Although the effect of case management in this study appeared
extremely limited, the short intervention period and characteristics of the
medical aid beneficiaries and the limit of controlling only the demand side were
discussed as factors to be considered. Nurses have been carrying out professional
roles in case management in Korea. However more efforts are needed to develop
case management as an area for nursing specialization.
DOI: 10.1016/j.anr.2014.10.001
PMID: 25529910 [Indexed for MEDLINE]
Author information:
(1)a Department of Mental Health , Johns Hopkins Bloomberg School of Public
Health , Baltimore , MD , USA.
(2)b Child and Adolescent Psychiatry , Johns Hopkins School of Medicine ,
Baltimore , MD , USA.
(3)c Pediatrics , Johns Hopkins School of Medicine , Baltimore , MD , USA.
DOI: 10.1080/09540121.2017.1394434
PMCID: PMC5987527
PMID: 29067834 [Indexed for MEDLINE]
Pen Devices for Insulin Self-Administration Compared With Needle and Vial:
Systematic Review of the Literature and Meta-Analysis.
Author information:
(1)Pontificia Universidad Javeriana, Medical School, Bogota, Colombia.
(2)Pontificia Universidad Javeriana, Medical School, Bogota, Colombia
NeuroEconomix SAS, Bogota, Colombia.
(3)Pontificia Universidad Javeriana, Medical School, Bogota, Colombia
diego.rosselli@gmail.com.
OBJECTIVES: Pen devices offer advantages compared with vial and syringe (VaS).
The purpose of this article was to evaluate efficacy of pen devices compared to
VaS.
METHODS: A systematic review of literature was performed in 8 different
databases. References were independently screened and selected. Primary
observational or experimental studies comparing pen devices with VaS for insulin
administrations were included. Studies on specific populations were excluded.
Risk of bias was evaluated using appropriate tools. Data on glycosylated
hemoglobin (HbA1c), hypoglycemia, adherence, persistence, patient preference, and
quality of life (QOL) were collected. Meta-analysis was performed when
appropriate. Heterogeneity and risk of publication bias were evaluated.
Otherwise, descriptive analyses of the available data was done.
RESULTS: In all, 10 348 articles were screened. A total of 17 studies were
finally selected: 7 experimental and 10 analytical. The populations of the
included articles were mainly composed of adults with type 2 diabetes mellitus.
Important risk of bias was found in all of the articles, particularly
experimental studies. Meta-analyses were performed for HbA1c, hypoglycemia,
adherence and persistence. Pen device showed better results in mean HbA1c change,
patients with hypoglycemia, adherence and persistence compared to VaS. No
difference was observed in number of patients achieving <7% HbA1c. Preference
studies showed a tendency favoring pen devices, however nonvalidated tools were
used. One QoL study showed improvements in some subscales of SF-36.
CONCLUSIONS: There is evidence that pen devices offer benefits in clinical and,
less clearly, patient-reported outcomes compared to VaS for insulin
administration. However, these results should be taken with caution.
DOI: 10.1177/1932296816633721
PMCID: PMC4928229 [Available on 2017-02-25]
PMID: 26920639 [Indexed for MEDLINE]
Author information:
(1)Division of Cardiovascular Medicine, Department of Medicine, University of
Wisconsin School of Medicine and Public Health, H4/512 CSC, MC 3248, 600 Highland
Avenue, Madison, WI, 53792, USA. hm2@medicine.wisc.edu.
(2)Health Innovation Program, University of Wisconsin School of Medicine and
Public Health, 800 University Bay Drive, Suite 210, Box 9445, Madison, WI, 53705,
USA. hm2@medicine.wisc.edu.
(3)Department of Counselor Education and Counseling Psychology, Marquette
University, Schroeder Health & Education Complex, 561 N 15th Street, Room 151A,
Milwaukee, WI, 53233, USA.
(4)Health Innovation Program, University of Wisconsin School of Medicine and
Public Health, 800 University Bay Drive, Suite 210, Box 9445, Madison, WI, 53705,
USA.
(5)Division of Rheumatology, Department of Medicine, University of Wisconsin
School of Medicine and Public Health, 4132 MFCB, Mail Code 2281, 1685 Highland
Avenue, Madison, WI, 53705, USA.
(6)Division of Cardiovascular Medicine, Department of Medicine, University of
Wisconsin School of Medicine and Public Health, H4/512 CSC, MC 3248, 600 Highland
Avenue, Madison, WI, 53792, USA.
BACKGROUND: Young adults (18-39 year-olds) have the lowest hypertension control
rates among adults with hypertension in the United States. Unique barriers to
hypertension management in young adults with primary care access compared to
older adults have not been evaluated. Understanding these differences will inform
the development of hypertension interventions tailored to young adults. The goals
of this multicenter study were to explore primary care providers' perspectives on
barriers to diagnosing, treating, and controlling hypertension among young adults
with regular primary care.
METHODS: Primary care providers (physicians and advanced practice providers)
actively managing young adults with uncontrolled hypertension were recruited by
the Wisconsin Research & Education Network (WREN), a statewide practice-based
research network. Semi-structured qualitative interviews were conducted in three
diverse Midwestern clinical practices (academic, rural, and urban clinics) using
a semi-structured interview guide, and content analysis was performed.
RESULTS: Primary care providers identified unique barriers across standard
hypertension healthcare delivery practices for young adults. Altered
self-identity, greater blood pressure variability, and unintended consequences of
medication initiation were critical hypertension control barriers among young
adults. Gender differences among young adults were also noted as barriers to
hypertension follow-up and antihypertensive medication initiation.
CONCLUSIONS: Tailored interventions addressing the unique barriers of young
adults are needed to improve population hypertension control. Augmenting
traditional clinic structure to support the "health identity" of young adults and
self-management skills are promising next steps to improve hypertension
healthcare delivery.
DOI: 10.1186/s13104-016-2332-8
PMCID: PMC5217565
PMID: 28057065 [Indexed for MEDLINE]
Yu Y(1), Luo D(2), Chen X(3), Huang Z(4), Wang M(5), Xiao S(1).
Author information:
(1)Department of Social Medicine and Health Management, Xiangya School of Public
Health, Central South University, Changsha, 410078, China.
(2)Department of Social Medicine and Health Management, Xiangya School of Public
Health, Central South University, Changsha, 410078, China.
luodan_csu_2011@126.com.
(3)Hunan Provincial Center for Disease Prevention and Control, Changsha, China.
(4)Changsha Center for Disease Prevention and Control, Changsha, China.
(5)HIV/AIDS Research Institute, The First Hospital of Changsha, Changsha, China.
BACKGROUND: Free antiretroviral therapy has been implemented in China since 2004,
but adherence to antiretroviral therapy among people living with HIV is
suboptimal. The effectiveness of antiretroviral therapy is subject to medication
adherence, which decreases with prolonged treatment times. The aim of this study
was to investigate medication adherence and related factors among people living
with HIV with newly initiated antiretroviral therapy.
METHODS: This observational study was conducted in consecutive samples of people
living with HIV who had newly initiated antiretroviral therapy. Participants were
recruited between March 1, 2013, and August 31, 2014, from the local Center for
Disease Control and Prevention and Infectious Disease hospital in a capital city
in central China. A standard set of questionnaires was adopted, including the
Community Programs for Clinical Research on AIDS Antiretroviral Medications and
Self-Report Questionnaire (CPCRA), the Patient Health Questionnaire-9 (PHQ-9) and
the 7-item Generalized Anxiety Disorder Scale (GAD-7). T-test, Chi square test
and multivariate logistic regression analysis with backward stepwise were
performed to explore factors that might influence medication adherence.
RESULTS: Of the 207 participants, 85.5% of the participants (177/207) were
categorized with good adherence, and 14.5% (30/207) with poor adherence. The
multivariate logistic regression analyses showed that participants with positive
depression (OR = 5.95, 95% CI: 2.34-15.11) and without disclosure of their HIV
status to others (OR = 2.62, 95% CI: 1.06-6.50) were more susceptible to poor
adherence.
CONCLUSIONS: One-sixth of the participants reported suboptimal medication
adherence within the first 6 months. Factors associated with poor adherence
included non-disclosure of their HIV status, had positive depression. Tailored
interventions, such as effective psychological coping strategies, should be
implemented for people living with HIV with newly initiated antiretroviral
therapy to improve their medication adherence.
DOI: 10.1186/s12889-018-5731-z
PMCID: PMC6030792
PMID: 29973167 [Indexed for MEDLINE]
Wu Y(1), Byrne EM(1), Zheng Z(1)(2), Kemper KE(1), Yengo L(1), Mallett AJ(1)(3),
Yang J(1)(2)(4), Visscher PM(5)(6), Wray NR(7)(8).
Author information:
(1)Institute for Molecular Bioscience, The University of Queensland, Brisbane,
QLD, 4072, Australia.
(2)Institute for Advanced Research, Wenzhou Medical University, 325027, Wenzhou,
Zhejiang, China.
(3)Department of Renal Medicine, Royal Brisbane and Women's Hospital, Herston,
QLD, 4029, Australia.
(4)Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072,
Australia.
(5)Institute for Molecular Bioscience, The University of Queensland, Brisbane,
QLD, 4072, Australia. peter.visscher@uq.edu.au.
(6)Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072,
Australia. peter.visscher@uq.edu.au.
(7)Institute for Molecular Bioscience, The University of Queensland, Brisbane,
QLD, 4072, Australia. naomi.wray@uq.edu.au.
(8)Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072,
Australia. naomi.wray@uq.edu.au.
DOI: 10.1038/s41467-019-09572-5
PMCID: PMC6478889
PMID: 31015401 [Indexed for MEDLINE]
Author information:
(1)Alpert School of Medicine, Brown University, Emergency Medicine, Rhode Island
Hospital, 55 Claverick St. #2, Providence, RI, 02903, USA.
taneisha_wilson@brown.edu.
(2)University Emergency Medicine Foundation, Kingston, Jamaica.
taneisha_wilson@brown.edu.
(3)University Hospital, University of the West Indies, Mona, Kingston, Jamaica.
(4)The University Hospital of the West Indies, Mona, Kingston, West Indies,
Jamaica.
(5)Department of Basic Medical Sciences, University of the West Indies, Mona,
Kingston, Jamaica.
(6)The University of the West Indies, Mona, Kingston, West Indies, Jamaica.
(7)Alpert School of Medicine, Brown University, Emergency Medicine, Rhode Island
Hospital, 55 Claverick St. #2, Providence, RI, 02903, USA.
(8)University Emergency Medicine Foundation, Kingston, Jamaica.
(9)Tropical Medicine Research Institute, University of the West Indies, Mona,
Kingston, Jamaica.
(10)Department of Emergency Medicine, Wayne State University, Detroit, MI, USA.
(11)Emergency Medicine, 6G4 University Health Center, Detroit, MI, 48201, USA.
DOI: 10.1186/s12245-018-0187-6
PMCID: PMC5976560
PMID: 29846823
Author information:
(1)Indiana University Richard M. Fairbanks School of Public Health, Department of
Epidemiology, Indianapolis, IN, United States. bedixon@regenstrief.org.
BACKGROUND: Patients with diabetes often have poor adherence to using medications
as prescribed. The reasons why, however, are not well understood. Furthermore,
most health care delivery processes do not routinely assess medication adherence
or the factors that contribute to poor adherence.
OBJECTIVE: The objective of the study was to assess the feasibility of an
integrated informatics approach to aggregating and displaying clinically relevant
data with the potential to identify issues that may interfere with appropriate
medication utilization and facilitate patient-provider communication during
clinical encounters about strategies to improve medication use.
METHODS: We developed a clinical dashboard within an electronic health record
(EHR) system that uses data from three sources: the medical record, pharmacy
claims, and a patient portal. Next, we implemented the dashboard into three
community health centers. Health care providers (n=15) and patients with diabetes
(n=96) were enrolled in a before-after pilot to test the system's impact on
medication adherence and clinical outcomes. To measure adherence, we calculated
the proportion of days covered using pharmacy claims. Demographic, laboratory,
and visit data from the EHR were analyzed using pairwise t tests. Perceived
barriers to adherence were self-reported by patients. Providers were surveyed
about their use and perceptions of the clinical dashboard.
RESULTS: Adherence significantly and meaningfully improved (improvements ranged
from 6%-20%) consistently across diabetes as well as cardiovascular drug classes.
Clinical outcomes, including HbA1c, blood pressure, lipid control, and emergency
department utilization remained unchanged. Only a quarter of patients (n=24)
logged into the patient portal and completed psychosocial questionnaires about
their barriers to taking medications.
CONCLUSIONS: Integrated approaches using advanced EHR, clinical decision support,
and patient-controlled technologies show promise for improving appropriate
medication use and supporting better management of chronic conditions. Future
research and development is necessary to design, implement, and integrate the
myriad of EHR and clinical decision support systems as well as patient-focused
information systems into routine care and patient processes that together support
health and well-being.
DOI: 10.2196/medinform.4739
PMCID: PMC4763113
PMID: 26858218
Mangla A(1), Doukky R(2), Powell LH(3), Avery E(3), Richardson D(4), Calvin JE
Jr(5).
Author information:
(1)Department of Preventive Medicine, Rush University Medical Center, Chicago,
Illinois, USA Department of Internal Medicine, OSF St. Francis Medical Center,
Peoria, Illinois, USA.
(2)Department of Preventive Medicine, Rush University Medical Center, Chicago,
Illinois, USA Division of Cardiology, John H. Stroger, Jr. Hospital of Cook
County, Chicago, Illinois, USA Division of Cardiology, Rush University Medical
Center, Chicago, Illinois, USA.
(3)Department of Preventive Medicine, Rush University Medical Center, Chicago,
Illinois, USA.
(4)Department of Preventive Medicine, Rush University Medical Center, Chicago,
Illinois, USA Department of Mathematics, Lake Forest College, Lake Forest,
Illinois, USA.
(5)Department of Medicine, University of Western Ontario, London, Ontario,
Canada.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://group.bmj.com/group/rights-licensing/permissions.
DOI: 10.1136/bmjopen-2014-006542
PMCID: PMC4256535
PMID: 25475245 [Indexed for MEDLINE]
Tran BX(1)(2), Hwang J(3), Nguyen LH(4), Nguyen AT(5), Latkin NR(2), Tran NK(6),
Minh Thuc VT(7), Nguyen HL(5), Phan HT(8), Le HT(1), Tran TD(9), Latkin CA(2).
Author information:
(1)Institute for Preventive Medicine and Public Health, Hanoi Medical University,
Hanoi, Vietnam.
(2)Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United
States of America.
(3)Department of Health Promotion, Daegu University, Gyeongsan, Republic of
Korea.
(4)School of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.
(5)Institute for Global Health Innovations, Duy Tan University, Da Nang, Vietnam.
(6)Woolcock Medical Research Institute, Hanoi, Vietnam.
(7)Department of Immunology and Allergy, National Otolaryngology Hospital, Hanoi,
Vietnam.
(8)Authority of HIV/AIDS Control, Ministry of Health, Hanoi, Vietnam.
(9)Department of Hepatobiliary Surgery, Vietnam-Germany Hospital, Hanoi, Vietnam.
1780. Diabetes Metab Syndr Obes. 2018 Jul 20;11:367-374. doi: 10.2147/DMSO.S170253.
eCollection 2018.
Author information:
(1)Preventive Medicine and Public Health Teaching and Research Unit, Health
Sciences Faculty, Rey Juan Carlos University, Alcorcón, Madrid, Spain,
rodrigo.jimenez@urjc.es.
(2)Respiratory Department, Hospital General Universitario Gregorio Marañón,
Madrid, Spain.
(3)Preventive Medicine and Public Health Department, Teaching and Research Unit,
University Hospital La Paz, Madrid, Spain.
Aims: To investigate the association between migraine and diabetes mellitus while
controlling for several socio-demographic characteristics, comorbidities, and
lifestyle variables. We also aimed to identify which of these variables are
associated with migraine among diabetics.
Patients and methods: We conducted a cross-sectional study using data taken from
the European Health Interview Surveys for Spain conducted in 2009/10 (n=22,188)
and 2014 (n=22,842). We selected those subjects ≥40 years of age. Diabetes status
was self-reported. One non-diabetic control was matched by the year of survey,
age, and sex for each diabetic case. The presence of migraine was defined as the
affirmative answer to both of the following questions: "Have you suffered
migraine or frequent headaches over the last 12 months?" and "Has your physician
confirmed the diagnosis?". Independent variables included demographic and
socio-economic characteristics, health status variables, lifestyle, and pain
characteristics.
Results: The prevalence of migraine was significantly higher among those
suffering from diabetes (14.9% vs. 13.0%; p=0.021). The multivariable analysis
showed that diabetes was not associated with a higher risk of migraine (adjusted
OR 1.06; 95%CI 0.89-1.25). Among diabetic subjects, female sex, suffering
concomitant mental disorders, respiratory disorders, neck pain, and low back pain
were variables associated with suffering from migraine.
Conclusion: We found no significant differences in the prevalence of migraine
between diabetics and non-diabetic age- and sex-matched controls after
controlling for possible confounders.
DOI: 10.2147/DMSO.S170253
PMCID: PMC6056164
PMID: 30050314
Bayliss EA(1), Powers JD(2), Ellis JL(2), Barrow JC(2), Strobel M(3), Beck A(2).
Author information:
(1)Kaiser Permanente Colorado Institute for Health Research; Department of Family
Medicine, University of Colorado School of Medicine.
(2)Kaiser Permanente Colorado Institute for Health Research.
(3)Kaiser Permanente Colorado, Department of Complete Health Solutions.
PURPOSE: Identifying care needs for newly enrolled or newly insured individuals
is important under the Affordable Care Act. Systematically collected
patient-reported information can potentially identify subgroups with specific
care needs prior to service use.
METHODS: We conducted a retrospective cohort investigation of 6,047 individuals
who completed a 10-question needs assessment upon initial enrollment in Kaiser
Permanente Colorado (KPCO), a not-for-profit integrated delivery system, through
the Colorado State Individual Exchange. We used responses from the Brief Health
Questionnaire (BHQ), to develop a predictive model for cost for receiving care in
the top 25 percent, then applied cluster analytic techniques to identify
different high-cost subpopulations. Per-member, per-month cost was measured from
6 to 12 months following BHQ response.
RESULTS: BHQ responses significantly predictive of high-cost care included
self-reported health status, functional limitations, medication use, presence of
0-4 chronic conditions, self-reported emergency department (ED) use during the
prior year, and lack of prior insurance. Age, gender, and deductible-based
insurance product were also predictive. The largest possible range of predicted
probabilities of being in the top 25 percent of cost was 3.5 percent to 96.4
percent. Within the top cost quartile, examples of potentially actionable
clusters of patients included those with high morbidity, prior utilization,
depression risk and financial constraints; those with high morbidity, previously
uninsured individuals with few financial constraints; and relatively healthy,
previously insured individuals with medication needs.
CONCLUSIONS: Applying sequential predictive modeling and cluster analytic
techniques to patient-reported information can identify subgroups of individuals
within heterogeneous populations who may benefit from specific interventions to
optimize initial care delivery.
DOI: 10.13063/2327-9214.1258
PMCID: PMC4975568
PMID: 27563684
Author information:
(1)School of Nursing, University of Wisconsin-Madison, Madison, USA
dko4@wisc.edu.
(2)College of Nursing, Seoul National University, Seoul, South Korea.
(3)School of Nursing, University of Wisconsin-Madison, Madison, USA Department of
Medicine, Section of Nephrology, University of Wisconsin-Madison School of
Medicine and Public Health, Madison, USA.
DOI: 10.1177/1742395315601415
PMCID: PMC5027924
PMID: 26289361 [Indexed for MEDLINE]
1783. Prim Care Companion CNS Disord. 2014 Nov 13;16(6). doi: 10.4088/PCC.14m01692.
eCollection 2014.
Author information:
(1)Departments of Psychiatry (Dr Sansone) and Internal Medicine (Drs Sansone and
Bohinc), Wright State University School of Medicine, Dayton, Ohio; Department of
Psychiatry Education, Kettering Medical Center, Kettering, Ohio (Dr Sansone); and
Department of Psychology, Columbia College, Columbia, South Carolina (Dr
Wiederman).
DOI: 10.4088/PCC.14m01692
PMCID: PMC4374826
PMID: 25834767
1784. HIV Med. 2015 Aug;16(7):393-402. doi: 10.1111/hiv.12223. Epub 2015 Jan 14.
Slot M(1), Sodemann M(1), Gabel C(2), Holmskov J(3), Laursen T(2), Rodkjaer L(2).
Author information:
(1)Department of Infectious Diseases, Odense University Hospital, Odense,
Denmark.
(2)Department of Infectious Diseases, Aarhus University Hospital, Aarhus,
Denmark.
(3)Department of Psychiatric Diseases, Odense University Hospital, Odense,
Denmark.
DOI: 10.1111/hiv.12223
PMID: 25585857 [Indexed for MEDLINE]
Xu J(1), Reale C, Slagle JM, Anders S, Shotwell MS, Dresselhaus T, Weinger MB.
Author information:
(1)Jie Xu, PhD, is Research Instructor, Department of Anesthesiology, School of
Medicine, Vanderbilt University, and The Center for Research and Innovation in
Systems Safety, Vanderbilt University Medical Center, Nashville, Tennessee.
Carrie Reale, RN-BC, MSN, is Informatics Nurse Specialist, Center for Research
and Innovation in Systems Safety, Vanderbilt University Medical Center,
Nashville, Tennessee. Jason M. Slagle, PhD, is Associate Professor of
Anesthesiology; and Shilo Anders, PhD, is Assistant Professor of Anesthesiology,
School of Medicine, Vanderbilt University, and The Center for Research and
Innovation in Systems Safety, Vanderbilt University Medical Center, Nashville,
Tennessee. Matthew S. Shotwell, PhD, is Assistant Professor of Anesthesiology and
Biostatistics School of Medicine, Vanderbilt University, and The Center for
Research and Innovation in Systems Safety, Vanderbilt University Medical Center,
Nashville, Tennessee. Timothy Dresselhaus, MD, MPH, is Chief of Primary Care
Service, VA San Diego Healthcare System, and Clinical Professor, Department of
Medicine, University of California, San Diego. Matthew B. Weinger, MD, is
Professor and Vice Chair of Anesthesiology, Professor of Biomedical Informatics
and Medical Education, Norman Ty Smith Chair in Patient Safety and Medical
Simulation, School of Medicine, Vanderbilt University; Director, The Center for
Research and Innovation in Systems Safety, Vanderbilt University Medical Center;
and Senior Physician Scientist, Geriatric Research Education and Clinical Center,
VA Tennessee Valley Healthcare System, Nashville, Tennessee.
DOI: 10.1097/NNR.0000000000000240
PMCID: PMC5679090
PMID: 28858143 [Indexed for MEDLINE]
Author information:
(1)VISN 4 Mental Illness Research, Education and Clinical Center (MIRECC), VA
Pittsburgh Healthcare System, Pittsburgh, PA, USA. Elizabeth.Dinapoli2@va.gov.
(2)Department of Psychiatry, University of Pittsburgh School of Medicine,
Pittsburgh, PA, USA. Elizabeth.Dinapoli2@va.gov.
(3)VISN 4 Mental Illness Research, Education and Clinical Center (MIRECC), VA
Pittsburgh Healthcare System, Pittsburgh, PA, USA.
(4)Graduate Center for Social and Public Policy, Duquesne University, Pittsburgh,
PA, USA.
(5)Dartmouth Centers for Health and Aging, Lebanon, NH, USA.
(6)CDC Health Promotion Research Center at Dartmouth, Lebanon, NH, USA.
(7)Department of Psychiatry, Geisel School of Medicine at Dartmouth, Pittsburgh,
PA, USA.
(8)Department of Sociology, Duquesne University, Pittsburgh, PA, USA.
(9)Western Psychiatric Institute and Clinic, University of Pittsburgh Medical
Center, Pittsburgh, PA, USA.
(10)MIRECC and Behavioral Health, VA Pittsburgh Healthcare System, Pittsburgh,
PA, USA.
(11)VA Pittsburgh Center for Health and Equity Promotion, Pittsburgh, PA, USA.
DOI: 10.1002/gps.4550
PMCID: PMC5839102
PMID: 27442187 [Indexed for MEDLINE]
Author information:
(1)Division for Heart Disease and Stroke Prevention, National Center for Chronic
Disease Prevention and Health Promotion, Centers for Disease Control and
Prevention, Atlanta, GA.
The authors used 2009 Behavioral Risk Factor Surveillance System data to assess
the prevalence of taking actions to control hypertension among adults with
self-reported hypertension. Differences by descriptive characteristics (sex, age,
race/ethnicity, access to health care, medication adherence), presence of other
health risk factors (overweight/obesity, smoking, heavy drinking, inadequate
fruit/vegetable intake, and physical inactivity), and comorbidities (diabetes,
high cholesterol, coronary heart disease, and stroke) were compared. The
prevalence of hypertension was 29.6%, and 75.0% of these patients reported taking
antihypertensive medications, 73.1% changed eating habits, 72.8% decreased the
use of salt, 78.8% reduced alcohol consumption, and 69.9% increased their
physical activity. Overall, 87.2% reported taking two or more actions to reduce
blood pressure. Patients taking antihypertensive medications were more likely to
take two or more actions than their counterparts (90.6% vs 79.4%, P<.01). Those
with at least one other health risk factor were 1.85 times as likely to take two
or more actions as their counterparts (95% confidence interval, 1.18-2.92 times).
More than 80% of hypertensive adults reported taking two or more actions to
control blood pressure. The prevalence of taking actions differed significantly
by descriptive characteristics, the presence health risk factors, and
comorbidities.
Published 2015. This article is a U.S. Government work and is in the public
domain in the USA.
DOI: 10.1111/jch.12476
PMCID: PMC6223011
PMID: 25644363 [Indexed for MEDLINE]
1788. Pediatr Transplant. 2016 Feb;20(1):130-40. doi: 10.1111/petr.12639.
Development and field testing of Teen Pocket PATH(®), a mobile health application
to improve medication adherence in adolescent solid organ recipients.
Author information:
(1)Department of Pediatric Transplant Surgery, School of Medicine University of
Pittsburgh, Pittsburgh, PA, USA.
(2)Hillman Center for Pediatric Transplantation, The Children's Hospital of
Pittsburgh of UPMC, Pittsburgh, PA, USA.
(3)Departments of Psychiatry, Psychology, Epidemiology and Biostatistics, School
of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
(4)Department of Acute and Tertiary Care, School of Nursing, University of
Pittsburgh, Pittsburgh, PA, USA.
Comment in
Pediatr Transplant. 2016 Feb;20(1):11-2.
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
DOI: 10.1111/petr.12639
PMCID: PMC5499533
PMID: 26916967 [Indexed for MEDLINE]
Kidd SA(1), Feldcamp L(2), Adler A(3), Kaleis L(3), Wang W(1), Vichnevetski K(2),
McKenzie K(1), Voineskos A(1).
Author information:
(1)University of Toronto, Department of Psychiatry, Toronto, Canada.
(2)Centre for Addiction and Mental Health, Toronto, Canada.
(3)MEMOTEXT, Toronto, Ontario, Canada.
DOI: 10.1371/journal.pone.0219491
PMCID: PMC6629069
PMID: 31306439
Conflict of interest statement: The authors have read the journal’s policy and
the authors of this manuscript have the following competing interests: AA and LK
are paid employees of MEMOTEXT. AA is also a principal of MEMOTEXT. SK and AA
have interests in the company App4Independence (A4i), a digital health engagement
platform to support people living with schizophrenia, which will house the
aforementioned app. MEMOTEXT holds 50% equity interest in A4i Inc. SK is a paid
employee of CAMH. CAMH holds a 35% equity interest in A4i Inc. The authors would
like to declare the following patents/patent applications associated with this
research: US 16/109,394, CDN 3,015,178, and AUS 2018220089; filed for “Tool For
Identifying Occurrence of Acute Incident Symptomatic of Mental Condition or
Disorder” filed August 22/23; 2018. This does not alter our adherence to all the
PLOS ONE policies on sharing data and materials. This does not alter our
adherence to PLOS ONE policies on sharing data and materials.
van den Hurk K(1), Zalpuri S(1), Prinsze FJ(1), Merz EM(1)(2), de Kort
WLAM(1)(3).
Author information:
(1)Department of Donor Studies, Sanquin Research, Amsterdam, The Netherlands.
(2)Department of Sociology, VU University, Amsterdam, The Netherlands.
(3)Department of Public Health, Academic Medical Center, Amsterdam, The
Netherlands.
INTRODUCTION: In donor health research, the 'Healthy Donor Effect' (HDE) often
biases study results and hampers their interpretation. This refers to the fact
that donors are a selected 'healthier' subset of a population due to both donor
selection procedures and self-selection. Donors with long versus short donor
careers, or with high versus low donation intensities are often compared to avoid
this HDE, but underlying health differences might also cause these differences in
behaviour. Our aim was to estimate to what extent a donor´s perceived health
status associates with donation cessation and intensity.
METHODS: All active whole blood donors participating in Donor InSight (2007-2009;
11,107 male; 12,616 female) were included in this prospective cohort study. We
performed Cox survival and Poisson regression analyses to assess whether
self-reported health status, medication use, disease diagnosed by a physician and
recently having consulted a general practitioner (GP) or specialist were
associated with (time to) donation cessation and donation intensity.
RESULTS: At the end of 2013, 44% of the donors in this study had stopped
donating. Donors in self-rated good health had a 15% lower risk to stop donating
compared to donors in perceived poorer health. Medication use, disease diagnoses
and consulting a GP were associated with a 20-40% increased risk to stop donating
and a lower donation intensity, when adjusting for age, number of donations and
new donor status. Both men and women reporting good health made on average 10%
more donations.
CONCLUSION: Donors with a "good" health status were less likely to stop donating
blood and tended to donate blood more often than donors with perceived poorer
health status. This implies that the HDE is an important source of selection bias
in studies on donor health and this includes studies where comparisons within
donors are made. This HDE should be adjusted for appropriately when assessing
health effects of donation and donors' health status may provide estimates of
future donation behavior.
DOI: 10.1371/journal.pone.0186662
PMCID: PMC5648214
PMID: 29049357 [Indexed for MEDLINE]
Author information:
(1)University of California, San Francisco, CA, UnitedStates
BACKGROUND: Transitioning youth with multiple sclerosis (MS) represent a
vulnerable group to potentially poor outcomes. It is unknown how pediatric MS
patients transition into adult care.
OBJECTIVES: To describe self-management skills that include adherence to
disease-modifying therapies, quality of life measures, illness perception,
transition readiness and healthcare skills assessments in patients with pediatric
MS and associations with clinical and cognitive outcomes.
METHODS: This is a prospective cross-sectional study at the pediatric MS center
and transitional MS clinic at the University of California, San Francisco.
Patients and one of their parents completed validated surveys for self-management
skills. Non-adherence is defined as not taking their medication more than 20% of
the time in the past 1 month. Wilcoxin matched-pairs rank test and McNemar's
tests were used for comparison of patient and parent responses. Univariate and
multivariate regression models were used for analyses adjusting for disease
duration and socio-economic status.
RESULTS: Thirty patients were enrolled with a mean (+/-SD) age of 15.8
years+/-2.8, 53% was female and 47% Hispanic. The rate of non-adherence was 37%.
The most common reason for non-adherence was forgetting to take their medication
reported in 50% of patients. In adjusted regression models, higher EDSS was
associated with a lower score on patient's quality of life (13 points decrease,
95% CI 6–18, p<0.0001), and lower healthcare skills (15 points decrease, 95%
CI5–26, p=0.006). Four points increase in Symbol Digit Modalities Test score was
associated a 0.1 increase in transition readiness score (95% CI0.07–0.2, p=0.001)
and 3.9 points increase in health care skills scores (95% CI 1.7–6, p=0.008).
DOI: 10.1016/j.msard.2014.09.088
PMCID: PMC4361811
PMID: 25798373 [Indexed for MEDLINE]
Author information:
(1)Department of Rehabilitation, Nursing Science and Sports, University Medical
Center Utrecht, HP W01.121, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands.
Electronic address: n.h.jonkman@vu.nl.
(2)Department of Rehabilitation, Nursing Science and Sports, University Medical
Center Utrecht, HP W01.121, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands.
(3)Department of Social and Welfare Studies, Linköping University, Linköping,
Sweden.
(4)Lienhard School of Nursing, College of Health Professions, Pace University,
New York, NY, USA.
(5)Julius Center for Health Sciences and Primary Care, University Medical Center
Utrecht, Utrecht, The Netherlands.
DOI: 10.1016/j.jclinepi.2016.08.001
PMID: 27531245 [Indexed for MEDLINE]
1794. Adv Ther. 2016 Jan;33(1):82-95. doi: 10.1007/s12325-015-0278-1. Epub 2016 Jan
21.
Fappa E(1), Efthymiou V(2), Landis G(2), Rentoumis A(3), Doupis J(4).
Author information:
(1)Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
(2)Center for Adolescent Medicine, First Department of Pediatrics, University of
Athens Medical School, Aghia Sophia Children's Hospital, Athens, Greece.
(3)Health Services Researcher, Vidavo Health Telematics, Thessaloníki, Greece.
(4)Iatriko Paleou Falirou Medical Center Division of Diabetes, Athens, Greece.
John.Doupis@joslin.harvard.edu.
DOI: 10.1007/s12325-015-0278-1
PMCID: PMC4735230
PMID: 26797897 [Indexed for MEDLINE]
Author information:
(1)School of Nursing and Midwifery, Deakin University, Melbourne, VIC, Australia.
alison.hutchinson@deakin.edu.au.
(2)Centre for Quality and Patient Safety Research, Deakin University, Melbourne,
VIC, Australia. alison.hutchinson@deakin.edu.au.
(3)Monash Health, Melbourne, VIC, Australia. alison.hutchinson@deakin.edu.au.
(4)Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann
Arbor, MI, USA. salesann@umich.edu.
(5)School of Nursing, University of Michigan, Ann Arbor, MI, USA.
salesann@umich.edu.
(6)School of Nursing and Midwifery, Deakin University, Melbourne, VIC, Australia.
vanessa.brotto@deakin.edu.au.
(7)School of Nursing and Midwifery, Deakin University, Melbourne, VIC, Australia.
tracey.bucknall@deakin.edu.au.
(8)Centre for Quality and Patient Safety Research, Deakin University, Melbourne,
VIC, Australia. tracey.bucknall@deakin.edu.au.
(9)Alfred Health, Melbourne, VIC, Australia. tracey.bucknall@deakin.edu.au.
DOI: 10.1186/s13012-015-0260-y
PMCID: PMC4443512
PMID: 25986004 [Indexed for MEDLINE]
Pantelic M(1)(2), Steinert JI(3), Park J(4), Mellors S(2), Murau F(2).
Author information:
(1)Department of Social Policy and Intervention, Oxford University, Oxford, UK.
(2)Frontline AIDS, Brighton, UK.
(3)Department of Economics, University of Goettingen, Goettingen, Germany.
(4)School of Experimental Medicine, University of British Columbia, Vancouver,
British Columbia, Canada.
DOI: 10.1136/bmjgh-2018-001285
PMCID: PMC6441299
PMID: 30997170
Henningfield JE(1)(2), Smith TT(3)(4), Kleykamp BA(5), Fant RV(5), Donny EC(6).
Author information:
(1)Pinney Associates, 4800 Montgomery Lane, Suite 400, Bethesda, MD, 20814, USA.
jhenning@pinneyassociates.com.
(2)Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University
School of Medicine, Baltimore, MD, USA. jhenning@pinneyassociates.com.
(3)University of Pittsburgh Cancer Institute, 4120 Sennott Square, 210 S. Bouquet
Street, Pittsburgh, PA, 15260, USA.
(4)Department of Epidemiology, Graduate School of Public Health, University of
Pittsburgh, 4120 Sennott Square, 210 S. Bouquet Street, Pittsburgh, PA, 15260,
USA.
(5)Pinney Associates, 4800 Montgomery Lane, Suite 400, Bethesda, MD, 20814, USA.
(6)Department of Psychology, University of Pittsburgh, 210 S. Bouquet Street,
Pittsburgh, PA, 15260, USA.
DOI: 10.1007/s00213-016-4441-4
PMCID: PMC5588156
PMID: 27766371 [Indexed for MEDLINE]
Risk Factors for Non-Adherence to cART in Immigrants with HIV Living in the
Netherlands: Results from the ROtterdam ADherence (ROAD) Project.
Been SK(1), van de Vijver DA(2), Nieuwkerk PT(3), Brito I(1), Stutterheim SE(4),
Bos AE(4), Wolfers ME(5), Pogány K(6), Verbon A(1).
Author information:
(1)Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam,
The Netherlands.
(2)Department of Virology, Erasmus University Medical Centre, Rotterdam, The
Netherlands.
(3)Department of Medical Psychology, Academic Medical Centre, Amsterdam, The
Netherlands.
(4)Faculty of Psychology and Educational Sciences, Open University of the
Netherlands, Heerlen, the Netherlands.
(5)Municipal Public Health Service Rotterdam-Rijnmond, Infectious Disease Control
Division, Rotterdam, The Netherlands.
(6)Department of Internal Medicine, Maasstad Hospital, Rotterdam, The
Netherlands.
In the Netherlands, immigrant people living with HIV (PLWH) have poorer
psychological and treatment outcomes than Dutch PLWH. This cross-sectional field
study examined risk factors for non-adherence to combination Antiretroviral
Therapy (cART) among immigrant PLWH. First and second generation immigrant PLWH
attending outpatient clinics at two HIV-treatment centers in Rotterdam were
selected for this study. Socio-demographic and clinical characteristics for all
eligible participants were collected from an existing database. Trained
interviewers subsequently completed questionnaires together with consenting
participants (n = 352) to gather additional data on socio-demographic
characteristics, psychosocial variables, and self-reported adherence to cART.
Univariable and multivariable logistic regression analyses were conducted among
301 participants who had used cART ≥6 months prior to inclusion. Independent risk
factors for self-reported non-adherence were (I) not having attended formal
education or only primary school (OR = 3.25; 95% CI: 1.28-8.26, versus
University), (II) experiencing low levels of social support (OR = 2.56; 95% CI:
1.37-4.82), and (III) reporting low treatment adherence self-efficacy (OR = 2.99;
95% CI: 1.59-5.64). Additionally, HIV-RNA >50 copies/ml and internalized
HIV-related stigma were marginally associated (P<0.10) with non-adherence (OR =
2.53; 95% CI: 0.91-7.06 and OR = 1.82; 95% CI: 0.97-3.43). The findings that low
educational attainment, lack of social support, and low treatment adherence
self-efficacy are associated with non-adherence point to the need for tailored
supportive interventions. Establishing contact with peer immigrant PLWH who serve
as role models might be a successful intervention for this specific population.
DOI: 10.1371/journal.pone.0162800
PMCID: PMC5051866
PMID: 27706251 [Indexed for MEDLINE]
Tan R(1), Cvetkovski B(1), Kritikos V(1), Price D(2)(3), Yan K(1)(4), Smith P(5),
Bosnic-Anticevich S(1)(6).
Author information:
(1)Quality Use of Respiratory Medicines Group, Woolcock Institute, University of
Sydney, Sydney, Australia.
(2)Academic Primary Care, University of Aberdeen, Aberdeen, UK.
(3)Observational and Pragmatic Research Institute Pte Ltd, Singapore, Singapore.
(4)Royal Prince Alfred Hospital, Sydney, Australia.
(5)Clinical Medicine, Griffith University, Southport, QLD Australia.
(6)Sydney Local Health District, Sydney, Australia.
DOI: 10.1186/s40733-017-0036-z
PMCID: PMC5696909
PMID: 29201385
Erbach M(1), Freckmann G(2), Hinzmann R(3), Kulzer B(4), Ziegler R(5), Heinemann
L(6), Schnell O(7).
Author information:
(1)Sciarc Institute, Baierbrunn, Germany.
(2)Institut für Diabetes-Technologie Forschungs- und Entwicklungsgesellschaft
mbH, Ulm, Germany.
(3)Roche Diabetes Care GmbH, Mannheim, Germany.
(4)Research Institute of the Diabetes Academy Mergentheim (FIDAM), Bad
Mergentheim, Germany.
(5)Diabetes Clinic for Children and Adolescents, Muenster, Germany.
(6)Science & Co GmbH, Düsseldorf, Germany.
(7)Forschergruppe Diabetes e.V., Munich-Neuherberg, Germany
oliver.schnell@lrz.uni-muenchen.de.
DOI: 10.1177/1932296816641433
PMCID: PMC5032951
PMID: 27044519 [Indexed for MEDLINE]
Lakshminarayana R(1), Wang D(2), Burn D(3), Chaudhuri KR(4), Galtrey C(5), Guzman
NV(6), Hellman B(1), Ben James(1), Pal S(7), Stamford J(8), Steiger M(9), Stott
RW(6), Teo J(4), Barker RA(10), Wang E(11), Bloem BR(12), van der Eijk M(12),
Rochester L(3), Williams A(13).
Author information:
(1)uMotif Ltd, London, UK.
(2)Liverpool School of Tropical Medicine, Liverpool, UK.
(3)Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
(4)King's College Hospital NHS Foundation Trust, London, UK.
(5)St George's Healthcare Trust, London, UK.
(6)John van Geest Centre for Brain Repair, Cambridge, UK.
(7)NHS Forth Valley, Scotland, UK.
(8)Cure Parkinson's Trust, London, UK.
(9)The Walton Centre NHS Foundation Trust, Liverpool, UK.
(10)John van Geest Centre for Brain Repair & Cambridge University Hospitals NHS
Trust, Cambridge, UK.
(11)Queen Mary University of London, London, UK.
(12)Radboud University Medical Center, Nijmegen, The Netherlands.
(13)University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Erratum in
NPJ Parkinsons Dis. 2017 Nov 13;3:32.
The progressive nature of Parkinson's disease, its complex treatment regimens and
the high rates of comorbid conditions make self-management and treatment
adherence a challenge. Clinicians have limited face-to-face consultation time
with Parkinson's disease patients, making it difficult to comprehensively address
non-adherence. Here we share the results from a multi-centre (seven centres)
randomised controlled trial conducted in England and Scotland to assess the
impact of using a smartphone-based Parkinson's tracker app to promote patient
self-management, enhance treatment adherence and quality of clinical
consultation. Eligible Parkinson's disease patients were randomised using a 1:1
ratio according to a computer-generated random sequence, stratified by centre and
using blocks of variable size, to intervention Parkinson's Tracker App or control
(Treatment as Usual). Primary outcome was the self-reported score of adherence to
treatment (Morisky medication adherence scale -8) at 16 weeks. Secondary outcomes
were Quality of Life (Parkinson's disease questionnaire -39), quality of
consultation for Parkinson's disease patients (Patient-centred questionnaire for
Parkinson's disease), impact on non-motor symptoms (Non-motor symptoms
questionnaire), depression and anxiety (Hospital anxiety and depression scale)
and beliefs about medication (Beliefs about Medication Questionnaire) at 16
weeks. Primary and secondary endpoints were analysed using a generalised linear
model with treatment as the fixed effect and baseline measurement as the
covariate. 158 patients completed the study (Parkinson's tracker app = 68 and
TAU = 90). At 16 weeks Parkinson's tracker app significantly improved adherence,
compared to treatment as usual (mean difference: 0.39, 95%CI 0.04-0.74;
p = 0.0304) with no confounding effects of gender, number of comorbidities and
age. Among secondary outcomes, Parkinson's tracker app significantly improved
patients' perception of quality of consultation (0.15, 95% CI 0.03 to 0.27;
p = 0.0110). The change in non-motor symptoms was -0.82 (95% CI -1.75 to 0.10;
p = 0.0822). 72% of participants in the Parkinson's tracker app group continued
to use and engage with the application throughout the 16-week trial period. The
Parkinson's tracker app can be an effective and novel way of enhancing
self-reported medication adherence and quality of clinical consultation by
supporting self-management in Parkinson's disease in patients owning smartphones.
Further work is recommended to determine whether the benefits of the intervention
are maintained beyond the 16 week study period.
DOI: 10.1038/s41531-016-0003-z
PMCID: PMC5460235
PMID: 28649602
Medication Adherence Mediates the Association between Type D Personality and High
HbA1c Level in Chinese Patients with Type 2 Diabetes Mellitus: A Six-Month
Follow-Up Study.
Li X(1), Gao M(2), Zhang S(2), Xu H(3), Zhou H(2), Wang X(2), Qu Z(2), Guo J(4),
Zhang W(2), Tian D(2).
Author information:
(1)School of Social Development and Public Policy, China Institute of Health,
Beijing Normal University, Beijing 100875, China; Clinics of Cadre, Department of
Outpatient, General Hospital of the People's Liberation Army (301 Hospital),
Beijing 100853, China.
(2)School of Social Development and Public Policy, China Institute of Health,
Beijing Normal University, Beijing 100875, China.
(3)Department of Public Health Sciences, University of Rochester School of
Medicine & Dentistry, Rochester, NY 14642, USA.
(4)Department of Sociology, Huazhong University of Science and Technology, Wuhan,
Hubei 430074, China.
Aims. To examine the association between Type D personality and HbA1c level and
to explore the mediating role of medication adherence between them in patients
with type 2 diabetes mellitus (T2DM). Methods. 330 patients went on to complete a
self-report measure of medication adherence and the HbA1c tests. Chi-square test,
T test, Ordinary Least Square Regression (OLS), and Recentered Influence Function
Regression (RIF) were employed. Results. Patients with Type D personality had
significantly higher HbA1c value (P < 0.01). When Type D personality was
operationalized as a categorical variable, SI was associated with HbA1c (P <
0.01). When NA, SI, and their interaction term were entered into regression, all
of them were no longer associated with HbA1c level (P > 0.1). On the other hand,
when Type D personality was operationalized as a continuous variable, only SI
trait was associated with HbA1c level (P < 0.01). When NA, SI, and NA × SI term
together were entered into regression, only SI was not related to HbA1c level.
Furthermore, medication adherence had a significant mediation effect between Type
D personality and HbA1c, accounting for 54.43% of the total effect. Conclusion.
Type D personality was associated with HbA1c in direct and indirect ways, and
medication adherence acted as a mediator role.
DOI: 10.1155/2017/7589184
PMCID: PMC5322451
PMID: 28280745 [Indexed for MEDLINE]
Conflict of interest statement: The authors declare that they have no competing
interests.
Wouters H(1), Van Dijk L(2), Geers HC(3), Winters NA(3), Van Geffen EC(3),
Stiggelbout AM(4), Bouvy ML(3).
Author information:
(1)Department of Pharmacy, Unit of Pharmacotherapy and Pharmaceutical Care,
Groningen Research Institute of Pharmacy, Faculty of Mathematics and Natural
Sciences, University of Groningen, Groningen, The Netherlands.
(2)NIVEL, Netherlands Institute for Health Services Research, Utrecht, The
Netherlands.
(3)Division of Pharmaco-epidemiology and Clinical Pharmacology, Utrecht Institute
for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The
Netherlands.
(4)Department of Medical Decision Making, Leiden University Medical Center,
Leiden, The Netherlands.
DOI: 10.1371/journal.pone.0146272
PMCID: PMC4726652
PMID: 26808151 [Indexed for MEDLINE]
Author information:
(1)Section of General Internal Medicine, Department of Medicine, The University
of Chicago Medicine, Chicago, IL, USA.
DOI: 10.1177/2050312118821119
PMCID: PMC6305947
PMID: 30627434
1805. Prim Health Care Res Dev. 2019 Jan;20:e4. doi: 10.1017/S1463423618000324.
Epub
2018 May 31.
The long and winding road: the journey taken by headache sufferers in search of
help.
Davies PTG(1), Lane RJM(2), Astbury T(1), Fontebasso M(3), Murphy J(3), Matharu
M(4).
Author information:
(1)1Department of Neurology,Northampton General Hospital,Billing
Road,Northampton,UK.
(2)4Department of Neurology,Ashford Hospital,Middlesex,UK.
(3)5York Headache Clinic (York District Hospital),York,UK.
(4)6The London Headache Group,National Hospital for Neurology and
Neurosurgery,Queen Square,London,UK.
AimTo outline the pathways a cohort of first attendees to our headache clinics
had taken over the years in search of explanations and treatment for their
headaches. To establish a greater awareness of the shortcomings and failures in
their medical journey in the hope that better headache management will emerge in
primary care. BACKGROUND: At first attendance in primary care most headache
sufferers will not receive a firm diagnosis. Treatments provided are often
ineffective and so many patients embark on a somewhat random self-made journey
searching for a remedy. If they reach a Headache Clinic the most common diagnoses
are 'chronic migraine' and 'medication overuse headache'. They are either no
better or worse than when their headaches first started despite their efforts.
METHOD: We undertook a prospective questionnaire-based study of over 200 patients
on first attendance at each of our headache clinics, three based in District
General Hospitals and one in a tertiary referral centre. We documented the
patients' headache characteristics, the 'burden' of their headaches, functional
handicap and the financial costs incurred seeking help before referral. We also
documented what our patients understood about their headache disorder and the
treatments previously tried.FindingsMost patients had not been given a formal
diagnosis in primary care and many remained unconvinced of the benign nature of
their headache problem and wanted further investigations. A few had sought help
from headache charities. Many had unrealistic attitudes to their problem and
medication overuse was rife. A few patients had been offered triptans in primary
care. Key deficiencies in the primary care management of these patients included
failure to provide a formal headache diagnosis, inadequate understanding of the
nature and mechanism of headaches and failure to follow a resilient management
strategy. We provide a more effective management pathway in primary care.
DOI: 10.1017/S1463423618000324
PMCID: PMC6476391
PMID: 29848391 [Indexed for MEDLINE]
Zemmour K(1)(2), Tinland A(1)(2), Boucekine M(1), Girard V(1)(2), Loubière S(1),
Resseguier N(1), Fond G(3), Auquier P(1)(4), Boyer L(1)(4); French Housing First
Study Group.
Author information:
(1)Aix-Marseille Univ., EA 3279 Research Unit, 13385 Marseille, France.
(2)Department of Psychiatry, Sainte-Marguerite University Hospital, Marseille,
France.
(3)Université Paris-Est Créteil, Pôle de psychiatrie des hôpitaux universitaires
H Mondor, INSERM U955, Eq Psychiatrie Génétique, Fondation FondaMental Fondation
de coopération scientifique en santé mentale, Pole de Psychiatrie, Hôpital A.
Chenevier, 40 rue de Mesly, Créteil, F-94010, France.
(4)Department of Public Health, University Hospital, Marseille, France.
The Medication Adherence Rating Scale (MARS) is one of the most widely used
measurements of adherence in schizophrenia (SZ), but there is no available data
regarding its psychometric properties in homeless SZ patients (HSZ). The aim of
this study was therefore to assess the psychometric properties of the MARS in a
large multicenter sample of HSZ subjects. This multi-centre prospective study was
conducted in the following 4 French cities: Lille, Marseille, Paris and Toulouse.
Three hundred and fifty-three patients were included. The 3-factor structure of
the MARS was confirmed using confirmatory factor analysis: RMSEA = 0.045,
CFI = 0.98, TLI = 0.97 and WRMR = 0.76. The unidimensionality of each factor was
supported by the satisfactory INFIT statistics. Item internal consistencies were
all higher than 0.20 and the Kuder-Richardson were higher than to 0.6, except for
factor 2, which was closed to 0.5. Significant associations with symptoms,
functioning and quality of life showed satisfactory external validity. The
acceptability was satisfactory with missing data lower than 5% for each
dimension. The MARS is a short self-administered instrument with acceptable
psychometric properties in homeless SZ patients that yields interesting
information about medication adherence.
DOI: 10.1038/srep31598
PMCID: PMC4989491
PMID: 27534796 [Indexed for MEDLINE]
Author information:
(1)Department of Health Studies, University of South Africa. ehlersjh@mweb.co.za.
DOI: 10.4102/curationis.v38i1.1255
PMCID: PMC6091787
PMID: 26244453 [Indexed for MEDLINE]
1808. BMC Complement Altern Med. 2019 Jan 15;19(1):17. doi: 10.1186/s12906-019-
2431-x.
Author information:
(1)NICM Health Research Institute, Western Sydney University, Building 5,
Campbelltown Campus, Locked Bag 1797, Penrith, Sydney, NSW, 2751, Australia.
m.armour@westernsydney.edu.au.
(2)NICM Health Research Institute, Western Sydney University, Building 5,
Campbelltown Campus, Locked Bag 1797, Penrith, Sydney, NSW, 2751, Australia.
(3)School of Science and Health, Western Sydney University, Sydney, Australia.
DOI: 10.1186/s12906-019-2431-x
PMCID: PMC6332532
PMID: 30646891 [Indexed for MEDLINE]
Arden MA(1), Drabble S(2), O'Cathain A(2), Hutchings M(3), Wildman M(2)(3).
Author information:
(1)Centre for Behavioural Science and Applied Psychology (CeBSAP), Sheffield
Hallam University, UK.
(2)School of Health and Related Research (ScHARR), University of Sheffield, UK.
(3)Sheffield Adult CF Centre, Northern General Hospital, Sheffield, UK.
© 2019 The Authors. British Journal of Health Psychology published by John Wiley
& Sons Ltd on behalf of British Psychological Society.
DOI: 10.1111/bjhp.12357
PMCID: PMC6519271
PMID: 30825258 [Indexed for MEDLINE]
Trigo JM(1), Lagzdins D(1), Rehm J(2), Selby P(3), Gamaleddin I(4), Fischer B(5),
Barnes AJ(6), Huestis MA(6), Le Foll B(7).
Author information:
(1)Translational Addiction Research Laboratory, Campbell Family Mental Health
Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto,
Canada.
(2)Social and Epidemiological Research Department, CAMH, Toronto, Canada;
Addiction Policy, Dalla Lana School of Public Health, University of Toronto,
Toronto, Canada; Institute of Medical Science, University of Toronto, Faculty of
Medicine, Toronto, Canada; Department of Psychiatry, University of Toronto,
Canada; Institute of Clinical Psychology and Psychotherapy & Center of Clinical
Epidemiology and Longitudinal Studies (CELOS), Technische Universität Dresden,
Dresden, Germany.
(3)Department of Psychiatry, University of Toronto, Canada; Addictions Division,
CAMH, Toronto, Canada; Department of Family and Community Medicine, University of
Toronto, Canada.
(4)Translational Addiction Research Laboratory, Campbell Family Mental Health
Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto,
Canada; Department of Medical Sciences, Institute of Environmental Studies and
Research, Ain Shams University, Cairo, Egypt; Directorate of Poison Control
Centres, MOH, Riyadh, Saudi Arabia.
(5)Social and Epidemiological Research Department, CAMH, Toronto, Canada;
Department of Psychiatry, University of Toronto, Canada; Centre for Applied
Research in Mental Health & Addiction, Faculty of Health Sciences, Simon Fraser
University, Vancouver, Canada.
(6)Chemistry and Drug Metabolism, National Institute on Drug Abuse (NIDA),
National Institutes of Health (NIH), Baltimore, USA.
(7)Translational Addiction Research Laboratory, Campbell Family Mental Health
Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto,
Canada; Addictions Division, CAMH, Toronto, Canada. Electronic address:
bernard.lefoll@camh.ca.
DOI: 10.1016/j.drugalcdep.2016.02.020
PMCID: PMC4878903
PMID: 26925704 [Indexed for MEDLINE]
Oh CK(1), Bang JB(1), Kim SJ(2), Huh KH(3), Kim SJ(4), Jeon JS(5), Han SY(6), Cho
HR(7), Kwon YJ(8), Lee SH(9), Kim YS(3).
Author information:
(1)Department of Surgery, Ajou University School of Medicine, Suwon, South Korea.
(2)Department of Surgery, Samsung Medical Center, Seoul, South Korea.
(3)Department of Transplantation Surgery, Severance Hospital, Yonsei University
Health System, Seoul, South Korea.
(4)Department of Surgery, CHA University School of Medicine, Seongnam, South
Korea.
(5)Department of Nephrology, Soon Chun Hyang University Hospital, Seoul, South
Korea.
(6)Department of Internal Medicine, Ilsan Paik Hospital, Goyang, South Korea.
(7)Department of Surgery, Ulsan University Hospital, Ulsan, South Korea.
(8)Department of Nephrology and Hypertension, Korea University Guro Hospital,
Seoul, South Korea.
(9)Department of Surgery, Ajou University School of Medicine, Suwon, South Korea.
Electronic address: dltngudgs@aumc.ac.kr.
DOI: 10.1016/j.asjsur.2019.07.011
PMID: 31353239
Low JK(1)(2), Manias E(3)(4)(5), Crawford K(6), Walker R(7)(8), Mulley WR(9)(10),
Toussaint ND(11)(12), Dooley M(13)(14), Kennedy E(9), Smith CL(15), Nalder M(16),
Yip D(11), Williams A(6).
Author information:
(1)Monash Nursing & Midwifery, Monash University, Clayton, Victoria, Australia.
jackee.low@gmail.com.
(2)School of Nursing and Midwifery, Centre for Quality and Patient Safety
Research, Deakin University, Burwood, Victoria, Australia. jackee.low@gmail.com.
(3)School of Nursing and Midwifery, Centre for Quality and Patient Safety
Research, Deakin University, Burwood, Victoria, Australia.
(4)The Royal Melbourne Hospital, Parkville, Victoria, Australia.
(5)Melbourne School of Health Sciences, The University of Melbourne, Parkville,
Victoria, Australia.
(6)Monash Nursing & Midwifery, Monash University, Clayton, Victoria, Australia.
(7)Department of Renal Medicine, Alfred Hospital, Melbourne, Victoria, Australia.
(8)Department of Medicine, Monash University, Melbourne, Victoria, Australia.
(9)Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia.
(10)Centre for Inflammatory Diseases, Department of Medicine, Monash University,
Clayton, Victoria, Australia.
(11)Department of Nephrology, The Royal Melbourne Hospital, Parkville, Victoria,
Australia.
(12)Department of Medicine, The University of Melbourne, Parkville, Victoria,
Australia.
(13)Alfred Health, Prahran, Victoria, Australia.
(14)Centre for Medicine Use and Safety, Monash University, Parkville, Victoria,
Australia.
(15)School of Public Health and Preventive Medicine, Monash University,
Melbourne, Victoria, Australia.
(16)Pharmacy Department, The Royal Melbourne Hospital, Parkville, Victoria,
Australia.
DOI: 10.1038/s41598-019-44002-y
PMCID: PMC6531445
PMID: 31118485
Achtyes E(1), Simmons A(2), Skabeev A(2), Levy N(2), Jiang Y(2), Marcy P(3),
Weiden PJ(2).
Author information:
(1)Cherry Health and Michigan State University College of Human Medicine, Grand
Rapids, MI, USA. achtyes@msu.edu.
(2)Alkermes, Inc., Waltham, MA, USA.
(3)Vanguard Research Group, Northwell Health System, Manhasset, NY, USA.
DOI: 10.1186/s12888-018-1856-y
PMCID: PMC6142379
PMID: 30223804 [Indexed for MEDLINE]
Author information:
(1)College of Pharmacy, Seoul National University, Seoul, Republic Of Korea.
songhhong@snu.ac.kr.
DOI: 10.2196/jmir.5813
PMCID: PMC4994927
PMID: 27450362 [Indexed for MEDLINE]
Pathania M(1), Dutt HK(2), Gogoi JB(3), Rathaur V(4), Singh G(5), Singh P(6).
Author information:
(1)Associate Professor, Department of Medicine, VCSGGMS&RI , Srikot, Srinagar,
Uttarakhand, India .
(2)Assistant Professor, Department of Pharmacology, Kannur Medical College ,
Anjarakandy, Kannur, Kerala, India .
(3)Professor, Department of Biochemistry, VCSGGMS&RI , Srikot, Srinagar,
Uttrakhand, India .
(4)Associate Professor, Department of Pediatrics, Government Doon Medical college
, Dehradun, Uttrakhand, India .
(5)Assistant Professor, Statistics, Department of Community Medicine, Lala Lajpat
Rai Memorial Medical College and S.V.B.P. Hospital , Meerut, India .
(6)Assistant Professor, Department of Ophthalmology, VCSGGMS&RI , Srinagar,
Uttarakhand, India .
DOI: 10.7860/JCDR/2016/16053.7271
PMCID: PMC4800563
PMID: 27042497
Roy É(1), Nolin MA(2), Traoré I(3), Leclerc P(4), Vasiliadis HM(5).
Author information:
(1)Full Professor, Faculty of Medicine, Université de Sherbrooke, Sherbrooke,
Quebec; Researcher, Research Chair on Addiction, Université de Sherbrooke,
Sherbrooke, Quebec.
(2)Graduate Student, Clinical Sciences Program, Université de Sherbrooke,
Sherbrooke, Quebec.
(3)Research Assistant, Direction des statistiques de santé, Institut de la
statistique du Québec, Montreal, Quebec.
(4)Public Health Officer, Direction de santé publique de l'agence de la santé et
des services sociaux de Montréal, Montreal, Quebec.
(5)Associate Professor, Faculty of Medicine, Université de Sherbrooke,
Sherbrooke, Quebec; Researcher, Charles LeMoyne Hospital Research Centre,
Greenfield Park, Quebec.
OBJECTIVE: To determine the prevalence and factors associated with nonmedical use
of prescription medication (NMUPM) among adolescents who use drugs (ages 12 to 17
years) in Quebec.
METHOD: Secondary data analyses were carried out with data from a 6-month study,
namely, the 2010-2011 Quebec Health Survey of High School Students-a large-scale
survey that sought to gain a better understanding of the health and well-being of
young Quebecers in high school. Bivariate and multivariate logistic regression
analyses were conducted to study NMUPM among adolescents who use drugs, according
to sociodemographic characteristics, peer characteristics, health indicators
(anxiety, depression, or attention-deficit disorder [ADD] with or without
hyperactivity), self-competency, family environment, and substance use (alcohol
and drug use) factors.
RESULTS: Among adolescents who had used drugs in the previous 12 months, 5.4%
(95% CI 4.9% to 6.0%) reported NMUPM. Based on multivariate analyses, having an
ADD (adjusted odds ratio [AOR] 1.47; 95% CI 1.13 to 1.91), anxiety disorder (AOR
2.14; 95% CI 1.57 to 2.92), low self-esteem (AOR 1.62; 95% CI 1.26 to 2.08), low
self-control (AOR 1.95; 95% CI 1.55 to 2.45), low parental supervision (AOR 1.43;
95% CI 1.11 to 1.83), regular alcohol use (AOR 1.72; 95% CI 1.36 to 2.16), and
polysubstance use (AOR 4.09; 95% CI 3.06 to 5.48) were associated with increased
odds of reporting NMUPM.
CONCLUSIONS: The observed prevalence of NMUPM was lower than expected. However,
the associations noted with certain mental health disorders and regular or heavy
use of other psychoactive substances are troubling. Clinical implications are
discussed.
DOI: 10.1177/070674371506001206
PMCID: PMC4679164
PMID: 26720824 [Indexed for MEDLINE]
1817. BMC Health Serv Res. 2017 Dec 27;17(1):845. doi: 10.1186/s12913-017-2794-y.
Author information:
(1)Charles Darwin University, Ellengowan Dr, Casuarina, Darwin, NT, 0810,
Australia. Jess.dedassel@menzies.edu.au.
(2)Menzies School of Health Research, Bld 58, Royal Darwin Hospital Campus,
Rocklands Drive, Tiwi, Darwin, NT, 0811, Australia.
DOI: 10.1186/s12913-017-2794-y
PMCID: PMC5745645
PMID: 29282117 [Indexed for MEDLINE]
Aihara N(1), Yamada H(1), Takahashi M(2), Inagaki A(2), Murakami S(2), Mase M(1).
Author information:
(1)Department of Neurosurgery, Nagoya City University Medical School.
(2)Department of Otorhinolaryngology, Nagoya City University Medical School.
DOI: 10.2176/nmc.oa.2017-0108
PMCID: PMC5735226
PMID: 29021412 [Indexed for MEDLINE]
Basheti IA(1), Hait SS(2), Qunaibi EA(3), Aburuz S(4), Bulatova N(5).
Author information:
(1)Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied
Sciences University , Amman ( Jordan ). dr_iman@asu.edu.jo.
(2)Department of Quality Assurance, Sanofi, Jeddah, ( Saudi Arabia ).
ssaqfelhait@hotmail.com.
(3)Department of Clinical Pharmacy, Faculty of Pharmacy, Applied Sciences
University . Amman ( Jordan ). eyadqunaibi@yahoo.com.
(4)Department of Biopharmaceutics & Clinical Pharmacy, University of Jordan .
Amman ( Jordan ). aburuz@gmail.com.
(5)Department of Biopharmaceutics & Clinical Pharmacy, University of Jordan .
Amman ( Jordan ). nboulatova@hotmail.com.
DOI: 10.18549/PharmPract.2016.01.639
PMCID: PMC4800011
PMID: 27011772
Anderson C(1), Kirkpatrick S(2), Ridge D(3), Kokanovic R(4), Tanner C(4).
Author information:
(1)School of Pharmacy, University Park, Nottingham, UK.
(2)Health Experiences Research Group, Nuffield Department of Primary Care Health
Sciences, University of Oxford, Oxford, UK.
(3)Deptartment of Psychology, University of Westminster, London, UK.
(4)School of Social Sciences, Monash University, Melbourne, Victoria, Australia.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://www.bmj.com/company/products-services/rights-and-licensing/
DOI: 10.1136/bmjopen-2015-008636
PMCID: PMC4710845
PMID: 26719312 [Indexed for MEDLINE]
What utility scores do mental health service users, healthcare professionals and
members of the general public attribute to different health states? A co-produced
mixed methods online survey.
Flood C(1), Barlow S(1), Simpson A(1), Burls A(2), Price A(3), Cartwright M(2),
Brini S(2); Service User and Carer Group Advising on Research (SUGAR) members.
Author information:
(1)Centre for Mental Health Research, School of Health Sciences, University of
London, London and East London NHS Foundation Trust, London, United Kingdom.
(2)Centre for Health Services Research, School of Health Sciences, University of
London, London, United Kingdom.
(3)Department of Continuing Education, University of Oxford, Oxford, United
Kingdom.
DOI: 10.1371/journal.pone.0205223
PMCID: PMC6198969
PMID: 30352071 [Indexed for MEDLINE]
Lorig K(1), Ritter PL, Turner RM, English K, Laurent DD, Greenberg J.
Author information:
(1)Stanford School of Medicine, Stanford University, Palo Alto, CA, United
States.
DOI: 10.2196/jmir.5568
PMCID: PMC4950850
PMID: 27342265 [Indexed for MEDLINE]
Author information:
(1)Boehringer Ingelheim Pharma GmbH & Co. KG, Medical Affairs Respiratory
Medicine, Ingelheim, Germany.
(2)Kantar Health, Epsom, Surrey, UK; RTI Health Solutions, Barcelona, Spain.
(3)University of Rostock, Department of Respiratory Medicine, Rostock, Germany.
Electronic address: marek.lommatzsch@med.uni-rostock.de.
BACKGROUND: The prevalence and the characteristics of poor asthma control among
adults treated with combinations of inhaled corticosteroids (ICS) and long-acting
beta-agonists (LABA) are not completely understood.
METHODS: Data from adult patients in Germany with self-reported asthma treated
with an ICS-LABA combination in the National Health and Wellness Survey (NHWS)
were analysed. Patients with well-controlled and not well-controlled asthma
according to the Asthma Control Test (ACT) score were compared, with respect to
socio-demographic characteristics, attitudes, adherence and outcomes.
RESULTS: Among the German patients with self-reported asthma (5.2% of the
respondents), 16.2% (382 patients) were treated with an ICS-LABA combination and
did not report concomitant chronic obstructive pulmonary disease, chronic
bronchitis or emphysema. In this subgroup, 55.8% had not well-controlled asthma
(ACT < 20). ICS-LABA treated patients with not well-controlled asthma were more
likely to report emergency visits (16.4% vs. 8.9%), missed more time from work
(absenteeism: 12.9% vs. 4.3%), were more impaired while at work (presenteeism:
29.0% vs. 14.9%) and were more likely to be women (69.0% vs. 57.4%), compared
with well-controlled patients. There were no significant differences in age, body
mass index, smoking, income, education or self-reported adherence between the two
groups, but different attitudes regarding the patient-physician relationship.
CONCLUSIONS: A substantial proportion of patients treated with ICS and LABA had
not well-controlled asthma. These patients did not differ from well-controlled
patients in terms of education or self-reported adherence, but in terms of their
attitudes regarding the patient-physician relationship.
DOI: 10.1016/j.rmed.2016.07.012
PMID: 27578472 [Indexed for MEDLINE]
1824. PLoS One. 2016 Jan 25;11(1):e0147896. doi: 10.1371/journal.pone.0147896.
eCollection 2016.
Russell S(1), Martin F(2), Zalwango F(3), Namukwaya S(3), Nalugya R(3), Muhumuza
R(3), Katongole J(3), Seeley J(3)(4).
Author information:
(1)School of International Development, University of East Anglia, Norwich
Research Park, Norwich, United Kingdom.
(2)External Research Associate, School of International Development, University
of East Anglia, Norwich, United Kingdom.
(3)Medical Research Council / Uganda Virus Research Institute, Uganda Research
Unit on AIDS, Entebbe, Uganda.
(4)London School of Hygiene and Tropical Medicine, London, United Kingdom.
The health of people living with HIV (PLWH) and the sustained success of
antiretroviral therapy (ART) programmes depends on PLWH's motivation and ability
to self-manage the condition over the long term, including adherence to drugs on
a daily basis. PLWH's self-management of HIV and their wellbeing are likely to be
interrelated. Successful self-management sustains wellbeing, and wellbeing is
likely to motivate continued self-management. Detailed research is lacking on
PLWH's self-management processes on ART in resource-limited settings. This paper
presents findings from a study of PLWH's self-management and wellbeing in Wakiso
District, Uganda. Thirty-eight PLWH (20 women, 18 men) were purposefully selected
at ART facilities run by the government and by The AIDS Support Organisation in
and around Entebbe. Two in-depth interviews were completed with each participant
over three or four visits. Many were struggling economically, however the
recovery of health and hope on ART had enhanced wellbeing and motivated
self-management. The majority were managing their condition well across three
broad domains of self-management. First, they had mobilised resources, notably
through good relationships with health workers. Advice and counselling had helped
them to reconceptualise their condition and situation more positively and see
hope for the future, motivating their work to self-manage. Many had also
developed a new network of support through contacts they had developed at the ART
clinic. Second, they had acquired knowledge and skills to manage their health, a
useful framework to manage their condition and to live their life. Third,
participants were psychologically adjusting to their condition and their new
'self': they saw HIV as a normal disease, were coping with stigma and had
regained self-esteem, and were finding meaning in life. Our study demonstrates
the centrality of social relationships and other non-medical aspects of wellbeing
for self-management which ART programmes might explore further and encourage.
DOI: 10.1371/journal.pone.0147896
PMCID: PMC4726730
PMID: 26807932 [Indexed for MEDLINE]
Comment in
Neuropsychiatr Dis Treat. 2017 Oct 04;13:2527-2530.
DOI: 10.2147/NDT.S113712
PMCID: PMC5003598
PMID: 27601908
Lindsay BR(1), Olufade T(2), Bauer J(3), Babrowicz J(3), Hahn R(3).
Author information:
(1)Center for Observational and Real-World Evidence, Merck & Co. Inc.,
Kenilworth, NJ, USA. Brianna_lindsay@merck.com.
(2)Center for Observational and Real-World Evidence, Merck & Co. Inc.,
Kenilworth, NJ, USA.
(3)Nielsen, New York, NY, USA.
DOI: 10.1007/s11657-016-0272-5
PMCID: PMC4851700
PMID: 27129487 [Indexed for MEDLINE]
Conflict of interest statement: BRL is an employee of Merck & Co., Inc. TO was an
employee of Merck & Co., Inc. at the time of the study. J. Bauer, J. Babrowicz,
and RH are employees of Nielsen, which received funding from Merck & Co., Inc.
for the participation in the study. The study was funded by Merck & Co., Inc.
Monahan M(1), Jowett S(1), Nickless A(2), Franssen M(2), Grant S(3), Greenfield
S(1), Hobbs FDR(2), Hodgkinson J(1), Mant J(4), McManus RJ(2).
Author information:
(1)From the Institute of Applied Health Research, University of Birmingham,
United Kingdom (M.M., S.J., S. Greenfield, J.H.).
(2)Nuffield Department of Primary Care Health Sciences, University of Oxford,
United Kingdom (A.N., M.F., F.D.R.H., R.J.M.).
(3)Translational Health Sciences, University of Bristol, United Kingdom (S.
Grant).
(4)Department of Public Health and Primary Care, University of Cambridge, United
Kingdom (J.M.).
DOI: 10.1161/HYPERTENSIONAHA.118.12415
PMCID: PMC6510405
PMID: 31067190
Author information:
(1)Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition,
Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
(2)Geriatric Medicine, Sahlgrenska University Hospital, Mölndal, Sweden.
(3)Mary McKillop Health Institute, Australian Catholic University, Melbourne,
Australia.
(4)Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK.
(5)Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition,
Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
daniel.sundh@gu.se.
(6)Geriatric Medicine, Sahlgrenska University Hospital, Mölndal, Sweden.
daniel.sundh@gu.se.
In a population-based study of older Swedish women, we investigated the
proportion of women treated with osteoporosis medication in relation to the
proportion of women eligible for treatment according to national guidelines. We
found that only a minority (22%) of those eligible for treatment were prescribed
osteoporosis medication.INTRODUCTION: Fracture rates increase markedly in old age
and the incidence of hip fracture in Swedish women is among the highest in the
world. Although effective pharmacological treatment is available, treatment rates
remain low. Limited data are available regarding treatment rates in relation to
fracture risk in a population-based setting in older women. Therefore, we aimed
to investigate the proportion of older women eligible for treatment according to
Swedish Osteoporosis Society (SvOS) guidelines.
METHODS: A population-based study was performed in Gothenburg in 3028 older women
(77.8 ± 1.6 years [mean ± SD]). Bone mineral density of the spine and hip was
measured with dual-energy X-ray absorptiometry. Clinical risk factors for
fracture and data regarding osteoporosis medication was collected with
self-administered questionnaires. Logistic regression was used to evaluate
whether the 10-year probability of sustaining a major osteoporotic fracture
(FRAX-score) or its components predicted treatment with osteoporosis medication.
RESULTS: For the 2983 women with complete data, 1107 (37%) women were eligible
for treatment using SvOS criteria. The proportion of these women receiving
treatment was 21.8%. For women eligible for treatment according to SvOS
guidelines, strong predictors for receiving osteoporosis medication were
glucocorticoid treatment (odds ratio (95% CI) 2.88 (1.80-4.59)) and prior
fracture (2.58 (1.84-3.61)).
CONCLUSION: This study demonstrates that a substantial proportion of older
Swedish women should be considered for osteoporosis medication given their high
fracture risk, but that only a minority receives treatment.
DOI: 10.1007/s00198-019-04872-4
PMCID: PMC6546648
PMID: 30805678
Rodis JL(1), Sevin A(1)(2), Awad MH(3), Porter B(1), Glasgow K(4), Hornbeck Fox
C(5), Pryor B(5).
Author information:
(1)1 The Ohio State University, Columbus, OH, USA.
(2)2 PrimaryOne Health, Columbus, OH, USA.
(3)3 AxessPointe Community Health Center/NEOMED, Akron, OH, USA.
(4)4 Health Partners of Western Ohio, Lima, OH, USA.
(5)5 Ohio Department of Health, Columbus, OH, USA.
DOI: 10.1177/2150131917701797
PMCID: PMC5932724
PMID: 28381095 [Indexed for MEDLINE]
Author information:
(1)Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research
Center, Baton Rouge, Louisiana, USA.
(2)Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia,
USA.
(3)Center for Clinical and Translational Sciences, Mayo Clinic, Rochester,
Minnesota, USA.
(4)Institute of Child and Adolescent Health, School of Public Health, Peking
University, Beijing, Beijing, China.
(5)Department of Epidemiology, Tulane University School of Public Health and
Tropical Medicine, New Orleans, Louisiana, USA.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://group.bmj.com/group/rights-licensing/permissions.
DOI: 10.1136/bmjopen-2014-006633
PMCID: PMC4401856
PMID: 25872937 [Indexed for MEDLINE]
Kong QH(1)(2), Yang LP(1)(2), Lai YR(2)(3), Qin HY(2)(4), He LZ(2)(5), Liu
YS(1)(2), Li YE(2)(5), Chen XJ(2)(5), Qiu MZ(1)(2), Wang ZX(1)(2), Wang Y(1)(2).
Author information:
(1)Department of Medical Oncology, Sun Yat-Sen University Cancer Center,
Guangzhou 510060, China.
(2)Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in
South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou
510060, China.
(3)Department of Gynecological Oncology, Sun Yat-Sen University Cancer Center,
Guangzhou 510060, China.
(4)Department of Nursing, Sun Yat-Sen University Cancer Center, Guangzhou 510060,
China.
(5)Department of Clinical Research, Sun Yat-Sen University Cancer Center,
Guangzhou 510060, China.
DOI: 10.7150/jca.30057
PMCID: PMC6603383
PMID: 31289597
Medication Adherence and Its Association with Health Literacy and Performance in
Activities of Daily Livings among Elderly Hypertensive Patients in Islamabad,
Pakistan.
Saqlain M(1), Riaz A(2), Malik MN(3), Khan S(4), Ahmed A(5), Kamran S(6), Ali
H(7).
Author information:
(1)Department of Pharmacy, Quaid-I-Azam University, Islamabad 45320, Pakistan.
msaqlain@bs.qau.edu.pk.
(2)Cardiology Department, Pakistan Institute of Medical Sciences (PIMS),
Islamabad 44080, Pakistan. dr.asadriaz13@gmail.com.
(3)Cardiology Department, Pakistan Institute of Medical Sciences (PIMS),
Islamabad 44080, Pakistan. drnaeempims@gmail.com.
(4)Department of Pharmacy, Quaid-I-Azam University, Islamabad 45320, Pakistan.
skhan@qau.edu.pk.
(5)Department of Pharmacy, Quaid-I-Azam University, Islamabad 45320, Pakistan.
aliahmed@bs.qau.edu.pk.
(6)Department of Pharmacy, Quaid-I-Azam University, Islamabad 45320, Pakistan.
kamran1978pk@yahoo.com.
(7)Department of Pharmacy, Quaid-I-Azam University, Islamabad 45320, Pakistan.
h.ali@qau.edu.pk.
Tan BK(1)(2), Tan SB(3), Chen LC(4), Chang KM(5), Chua SS(1)(6), Balashanker
S(7), Kamarul Jaman HNB(5), Edmund SC(8), Bee PC(3).
Author information:
(1)Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala
Lumpur, Malaysia.
(2)Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, UCSI
University, Kuala Lumpur, Malaysia.
(3)Department of Medicine, Faculty of Medicine, University of Malaya, Kuala
Lumpur, Malaysia.
(4)Division of Pharmacy and Optometry, School of Health Sciences, University of
Manchester, Manchester, UK.
(5)Department of Hematology, Ampang Hospital, Ampang, Selangor, Malaysia.
(6)School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's
University, Lakeside Campus, Subang, Selangor, Malaysia.
(7)School of Pharmacy, University of Nottingham Malaysia Campus, Semenyih,
Selangor, Malaysia.
(8)Clinical Research Center, Ampang Hospital, Ampang, Selangor, Malaysia.
PURPOSE: Poor adherence to tyrosine kinase inhibitors (TKIs) could compromise the
control of chronic myeloid leukemia (CML) and contributes to poorer survival.
Little is known about how medication-related issues affect CML patients'
adherence to TKI therapy in Malaysia. This qualitative study aimed to explore
these issues.
PATIENTS AND METHODS: Individual face-to-face, semistructured interviews were
conducted at the hematology outpatient clinics of two medical centers in Malaysia
from August 2015 to January 2016. CML patients aged ≥18 years who were prescribed
a TKI were invited to participate in the study. Interviews were audio-recorded,
transcribed verbatim, and thematically analyzed.
RESULTS: Four themes were identified from 18 interviews: 1) concerns about
adverse reactions to TKIs, 2) personal beliefs regarding the use of TKIs, 3)
mismanagement of TKIs in daily lives, and 4) financial burden in accessing
treatment. Participants skipped their TKIs due to ineffective emesis control
measures and perceived wastage of medication from vomiting. Participants also
modified their TKI therapy due to fear of potential harm from long-term use, and
stopped taking their TKIs based on belief in curative claims of traditional
medicines and misconception about therapeutic effects of TKIs. Difficulty in
integrating the dosing requirements of TKIs into daily lives led to unintentional
skipping of doses, as well as the risk of toxicities from inappropriate dosing
intervals or food interactions. Furthermore, financial constraints also resulted
in delayed initiation of TKIs, missed clinic appointments, and treatment
interruptions.
CONCLUSION: Malaysian CML patients encountered a range of medication-related
issues leading to a complex pattern of nonadherence to TKI therapy. Further
studies should investigate whether regular contact with patients to improve
understanding of treatment rationale, to elicit and address patients' concerns
about adverse reactions, and to empower patients with skills to self-manage their
medications might promote better adherence to TKIs and improve CML patients'
outcome.
DOI: 10.2147/PPA.S132894
PMCID: PMC5476765
PMID: 28652712
Levin JB(1), Aebi ME(1), Tatsuoka C(1), Cassidy KA(1), Sajatovic M(1).
Author information:
(1)Dr. Levin and Dr. Sajatovic are with the Department of Psychiatry and Dr.
Tatsuoka is with the Department of Neurology, Case Western Reserve University
School of Medicine, Cleveland, Ohio (e-mail: jennifer.levin@uhhospitals.org ).
Dr. Levin, Dr. Tatsuoka, and Dr. Sajatovic are also with the Neurological and
Behavioral Outcomes Center, University Hospitals Case Medical Center, Cleveland,
where Ms. Aebi and Ms. Cassidy are with the Department of Psychiatry.
DOI: 10.1176/appi.ps.201500010
PMCID: PMC4934383 [Available on 2017-03-01]
PMID: 26695494 [Indexed for MEDLINE]
Author information:
(1)School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle,
Ethiopia. s.weldegebreal@gmail.com.
(2)School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle,
Ethiopia.
(3)Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College
of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Erratum in
BMC Res Notes. 2018 Aug 16;11(1):592.
DOI: 10.1186/s13104-018-3139-6
PMCID: PMC5769214
PMID: 29335003 [Indexed for MEDLINE]
DOI: 10.1089/dia.2016.0294
PMCID: PMC5248539
PMID: 28099052 [Indexed for MEDLINE]
Shen L(1)(2), Vavalle JP(2), Broderick S(3), Shaw LK(3), Douglas PS(3).
Author information:
(1)Shanghai Renji Hospital, School of Medicine, Shanghai Jiaotong University,
Shanghai, China.
(2)School of Medicine, University of North Carolina, Chapel Hill.
(3)The Duke Clinical Research Institute, Duke University Medical Center, Durham,
North Carolina.
BACKGROUND: Antianginal medications are a class I recommendation by the American
College of Cardiology/American Heart Association guidelines for stable ischemic
heart disease. We sought to better understand guidance in drug selection and
real-life outcomes of antianginal medication use.
HYPOTHESIS: In patients with stable ischemic heart disease, antianginal
medications lower mortality.
METHODS: We evaluated 5608 patients with obstructive coronary artery disease
(CAD) on elective cardiac catheterization with follow-up through
self-administered questionnaires. Patients were classified as being prescribed a
particular medication if they received that medication at index catheterization,
or within 3 months postcatheterization. The association between antianginal
medication use and outcomes was evaluated using Cox proportional hazards models.
RESULTS: Compared with the 11% not prescribed any antianginal medication,
patients prescribed antianginal medication were more likely to be older and
female; have a history of hypertension, diabetes mellitus, peripheral vascular
disease, or 3-vessel CAD; have lower adjusted mortality (hazard ratio [HR]: 0.75,
95% confidence interval [CI]: 0.63-0.89); and experience mortality or myocardial
infarction (HR: 0.83, 95% CI: 0.71-0.98). Compared with patients not taking
β-blockers (17%), those taking β-blockers had a lower risk of mortality (HR:
0.76, 95% CI: 0.66-0.88). Patients prescribed calcium channel blockers or
long-acting nitrates had a higher risk of mortality compared with nonusers (HR:
1.16, 95% CI: 1.04-1.29; HR: 1.20, 95% CI: 1.08-1.34; respectively).
CONCLUSIONS: Antianginal medications are not universally prescribed among
obstructive CAD patients; nonuse was associated with higher mortality. For CAD
patients with or without prior myocardial infarction, β-blockers were associated
with improved long-term survival.
DOI: 10.1002/clc.22594
PMCID: PMC6490842
PMID: 28026916 [Indexed for MEDLINE]
Konecny J(1), Klvacek A(2), Simek M(2), Lonsky V(2), Santavy P(2).
Author information:
(1)Department of Cardiac Surgery, University Hospital, Olomouc, Czech Republic.
Electronic address: kkubik@seznam.cz.
(2)Department of Cardiac Surgery, University Hospital, Olomouc, Czech Republic.
Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.ijscr.2016.05.014
PMCID: PMC4885112
PMID: 27232290
Author information:
(1)Department of Sociology, Trent University, 1600 West Bank Drive, Peterborough,
Canada, K9L 0G2.
(2)Leslie Dan Faculty of Pharmacy, University of Toronto, Canada.
(3)School of Pharmacy, University of Otago, Room 505a, Fifth Floor, Dunedin 9054,
New Zealand.
(4)School of Dentistry, University of Otago, PO Box 56, Dunedin, New Zealand.
DOI: 10.1016/j.ssmph.2017.11.002
PMCID: PMC5769117
PMID: 29349271
Author information:
(1)Lindner Center of HOPE, Mason, OH, USA; Department of Psychiatry and
Behavioral Neuroscience, University of Cincinnati College of Medicine,
Cincinnati, OH, USA.
Binge eating disorder (BED) is the most common eating disorder and an important
public health problem. It is characterized by recurrent episodes of excessive
food consumption accompanied by a sense of loss of control over the binge eating
behavior without the inappropriate compensatory weight loss behaviors of bulimia
nervosa. BED affects both sexes and all age groups and is associated with medical
and psychiatric comorbidities. Until recently, self-help and psychotherapy were
the primary treatment options for patients with BED. In early 2015,
lisdexamfetamine dimesylate, a prodrug stimulant marketed for attention deficit
hyperactive disorder, was the first pharmacologic agent to be approved by the US
Food and Drug Administration for the treatment of moderate or severe BED in
adults. This article summarizes BED clinical presentation, and discusses the
pharmacokinetic profile, efficacy, and safety of lisdexamfetamine dimesylate in
the treatment of BED in adults.
DOI: 10.2147/NDT.S80881
PMCID: PMC4841437
PMID: 27143885
1841. Health Lit Res Pract. 2018 Jan 23;2(1):e1-e14. doi: 10.3928/24748307-
20171227-01.
eCollection 2018 Jan.
DOI: 10.3928/24748307-20171227-01
PMCID: PMC6608909
PMID: 31294272
1842. J Gen Fam Med. 2017 Apr 4;18(2):52-55. doi: 10.1002/jgf2.39. eCollection 2017
Apr.
Author information:
(1)Department of Medicine JCHO Tokyo Joto Hospital Kotoku Tokyo Japan.
(2)Department of Emergency Medicine Cornell University School of Medicine New
York NY USA.
(3)Japan Community Healthcare Association (JCHO) Tokyo Japan.
DOI: 10.1002/jgf2.39
PMCID: PMC5689387
PMID: 29263991
1843. Rev Soc Bras Med Trop. 2016 Apr;49(2):248-51. doi: 10.1590/0037-8682-0275-
2015.
Author information:
(1)Faculdade de Farmácia, Universidade Federal do Pará, Belém, Pará, Brazil.
INTRODUCTION We investigated the association between demographic and behavioral
factors and non-adherence to antimalarial therapy. METHODS A demographic
questionnaire and 5-item self-reported questionnaire regarding non-adherence were
completed by 135 patients after treatment for Plasmodium vivax. RESULTS Treatment
interruption, but not demographic factors, was significantly associated with
non-adherence to therapy. The likelihood of non-adherence was 5.16 times higher
when the patients felt better than when they felt worse. The relative risk of
parasitic resurgence was 3.04 times higher in non-adherent patients. CONCLUSIONS
Treatment interruption is significantly associated with treatment adherence.
DOI: 10.1590/0037-8682-0275-2015
PMID: 27192598 [Indexed for MEDLINE]
1844. Prim Care Companion CNS Disord. 2015 Jul 30;17(4). doi: 10.4088/PCC.14m01760.
eCollection 2015.
Author information:
(1)The Menninger Clinic and Menninger Department of Psychiatry and Behavioral
Sciences, Baylor College of Medicine, Houston, Texas.
DOI: 10.4088/PCC.14m01760
PMCID: PMC4664564
PMID: 26693036
Author information:
(1)CUNY School of Public Health, Hunter College, New York, NY.
BACKGROUND AND OBJECTIVES: High rates of unintended pregnancy and need for
reproductive health services (RHS), including abortion, require continued efforts
to train medical professionals and increase availability of these services. With
US approval 12 years ago of Mifepristone, a medication abortion pill, abortion
services are additionally amenable to primary care. Family physicians are a
logical group to focus on given that they provide the bulk of primary care.
METHODS: We analyzed data from an annual survey (2007--2010) of third-year family
medicine residents (n=284, response rate=48%--64%) in programs offering abortion
training to examine the association between such training and self-reported
competence and intentions to provide RHS (with a particular focus on abortion)
upon graduation from residency.
RESULTS: The majority of residents (75% in most cases) were trained in each of
the RHS we asked about; relatively fewer trained in implant insertion (39%),
electric vacuum aspiration (EVA) (58%), and manual vacuum aspiration (MVA) (69%).
Perceived competence on the part of the graduating residents ranged from high
levels in pregnancy options counseling (89%) and IUD insertion (85%) to lows in
ultrasound and EVA (both 34%). Bivariate analysis revealed significant
associations between number of procedures performed and future intentions to
provide them. The association between competence and intentions persisted for all
procedures in multivariate analysis, adjusting for number of procedures. Further,
the total number of abortions performed during residency increased the odds of
intending to provide MVA and medication abortion by 3% and 2%, respectively.
CONCLUSIONS: Findings support augmenting training in RHS for family medicine
residents, given that almost half (45%) of those trained intended to provide
abortions. The volume of training should be increased so more residents feel
competent, particularly in light of the fact that combined exposure to different
abortion procedures has a cumulative impact on intention to provide MVA and
medication abortion.
Rigotti NA(1), Tindle HA(2), Regan S(3), Levy DE(4), Chang Y(5), Carpenter KM(6),
Park ER(7), Kelley JH(8), Streck JM(9), Reid ZZ(8), Ylioja T(10), Reyen M(11),
Singer DE(5).
Author information:
(1)Tobacco Research and Treatment Center, Massachusetts General Hospital, Boston,
Massachusetts; Division of General Internal Medicine, Department of Medicine,
Massachusetts General Hospital, Boston, Massachusetts; Mongan Institute for
Health Policy, Massachusetts General Hospital and Partners HealthCare, Boston,
Massachusetts; Department of Medicine, Harvard Medical School, Boston,
Massachusetts. Electronic address: nrigotti@partners.org.
(2)Department of Medicine, Vanderbilt University School of Medicine, Nashville,
Tennessee.
(3)Tobacco Research and Treatment Center, Massachusetts General Hospital, Boston,
Massachusetts; Division of General Internal Medicine, Department of Medicine,
Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine,
Harvard Medical School, Boston, Massachusetts.
(4)Tobacco Research and Treatment Center, Massachusetts General Hospital, Boston,
Massachusetts; Mongan Institute for Health Policy, Massachusetts General Hospital
and Partners HealthCare, Boston, Massachusetts; Department of Medicine, Harvard
Medical School, Boston, Massachusetts.
(5)Division of General Internal Medicine, Department of Medicine, Massachusetts
General Hospital, Boston, Massachusetts; Department of Medicine, Harvard Medical
School, Boston, Massachusetts.
(6)Alere Wellbeing, Inc., Seattle, Washington.
(7)Tobacco Research and Treatment Center, Massachusetts General Hospital, Boston,
Massachusetts; Mongan Institute for Health Policy, Massachusetts General Hospital
and Partners HealthCare, Boston, Massachusetts; Department of Psychiatry, Harvard
Medical School, Boston, Massachusetts.
(8)Tobacco Research and Treatment Center, Massachusetts General Hospital, Boston,
Massachusetts; Mongan Institute for Health Policy, Massachusetts General Hospital
and Partners HealthCare, Boston, Massachusetts.
(9)Department of Psychological Science, University of Vermont, Burlington,
Vermont.
(10)Department of Medicine, University of Pittsburgh School of Medicine,
Pittsburgh, Pennsylvania.
(11)Tobacco Research and Treatment Center, Massachusetts General Hospital,
Boston, Massachusetts; Division of General Internal Medicine, Department of
Medicine, Massachusetts General Hospital, Boston, Massachusetts.
DOI: 10.1016/j.amepre.2016.04.005
PMCID: PMC5031242
PMID: 27647060 [Indexed for MEDLINE]
Zhou L(1), Stearns SC, Thudium EM, Alburikan KA, Rodgers JE.
Author information:
(1)*Lineberger Comprehensive Cancer Center †Gillings School of Global Public
Health ‡UNC Eshelman School of Pharmacy, The University of North Carolina at
Chapel Hill, Chapel Hill, NC.
OBJECTIVE: Medicare Part D claims are commonly used for research, but missing
claims could compromise their validity. This study assessed 2 possible causes of
missing claims: veteran status and Generic Drug Discount Programs (GDDP).
MATERIALS AND METHODS: We merged medication self-reports from telephone
interviews in the Atherosclerosis Risk in Communities (ARIC) Study with Part D
claims for 6 medications (3 were commonly in GDDP in 2009). Merged records (4468)
were available for 2905 ARIC participants enrolled in Part D. Multinomial logit
regression provided estimates of the association of concordance (self-report and
Part D, self-report only, or Part D only) with veteran and GDDP status,
controlling for participant sociodemographics.
RESULTS: Sample participants were 74±5 years of age, 68% white and 63% female;
19% were male veterans. Compared with females, male veterans were 11% [95%
confidence interval (CI), 7%-16%] less likely to have matched medications in
self-report and Part D and 11% (95% CI, 7%-16%) more likely to have self-report
only. Records for GDDP versus non-GDDP medications were 4% (95% CI, 1%-7%) more
likely to be in self-report and Part D and 3% (95% CI, 1%-5%) less likely to be
in Part D only, with no difference in self-report only.
CONCLUSIONS: Part D claims were more likely to be missing for veterans, but
claims for medications commonly available through GDDP were more likely to match
with self-reports. Although researchers should be aware of the possibility of
missing claims, GDDP status was associated with a higher rather than lower
likelihood of claims being complete in 2009.
DOI: 10.1097/MLR.0000000000000341
PMCID: PMC4646610
PMID: 25793271 [Indexed for MEDLINE]
Author information:
(1)Department of Ophthalmology, Hafsa Sultan Hospital, Celal Bayar University,
Faculty of Medicine, Manisa, Turkey.
(2)Department of Ophthalmology, Sifa University Faculty of Medicine, 35410 Izmir,
Turkey.
DOI: 10.1155/2016/9183272
PMCID: PMC4826945
PMID: 27119046
Bridging the Gap Between Self-Reported and Claims-Derived Adherence Measures for
Basal Insulin Among Patients with Type 2 Diabetes Mellitus.
Author information:
(1)HealthCore, Inc., Wilmington, DE, USA. jstephenson@healthcore.com.
(2)Eli Lilly and Company, Indianapolis, IN, USA.
(3)Merck & Co., Inc., Kenilworth, NJ, USA.
(4)Janssen Research & Development, Titusville, NJ, USA.
DOI: 10.1007/s12325-018-0828-4
PMCID: PMC6318230
PMID: 30536142
Author information:
(1)Department of Health Care Management, Technical University of Berlin, Berlin,
Germany. victor.stephani@tu-berlin.de.
(2)Department of Health Care Management, Technical University of Berlin, Berlin,
Germany.
(3)Division of Tropical and Humanitarian Medicine, University of Geneva and
Geneva University Hospitals, Genève, Switzerland.
DOI: 10.1186/s12889-018-6050-0
PMCID: PMC6162903
PMID: 30268115 [Indexed for MEDLINE]
Author information:
(1)1 University of Missouri Informatics Institute, University of Missouri,
Columbia, MO, USA.
(2)2 Department of Medicine, University of Missouri, Columbia, MO, USA.
(3)3 Department of Health Management and Informatics, University of Missouri,
Columbia, MO, USA.
DOI: 10.1177/1932296818754907
PMCID: PMC6134307
PMID: 29390917 [Indexed for MEDLINE]
Author information:
(1)Department of Pharmacology, School of Medicine and Health Sciences, University
for Development Studies, P.O.Box TL 1350, Tamale, Ghana. sokpesh@yahoo.com.
(2)Department of Health Professions Education and Innovative Learning, School of
Medicine and Health Sciences, University for Development Studies, Tamale, Ghana.
(3)Department of Pharmacology, School of Medicine and Health Sciences, University
for Development Studies, P.O.Box TL 1350, Tamale, Ghana.
DOI: 10.1186/s12905-018-0532-1
PMCID: PMC5810012
PMID: 29433488 [Indexed for MEDLINE]
Buis L(1), Hirzel L(2), Dawood RM(3), Dawood KL(3), Nichols LP(1), Artinian
NT(2), Schwiebert L(4), Yarandi HN(2), Roberson DN(1), Plegue MA(1), Mango LC(3),
Levy PD(3).
Author information:
(1)Department of Family Medicine, University of Michigan, Ann Arbor, MI, United
States.
(2)College of Nursing, Wayne State University, Detroit, MI, United States.
(3)Department of Emergency Medicine, School of Medicine, Wayne State University,
Detroit, MI, United States.
(4)College of Engineering, Wayne State University, Detroit, MI, United States.
DOI: 10.2196/mhealth.6630
PMCID: PMC5311421
PMID: 28148474
1854. J Gen Intern Med. 2015 Oct;30(10):1538-46. doi: 10.1007/s11606-015-3288-4.
Epub
2015 Apr 28.
Author information:
(1)Program on Health Care and Prevention, Gillings School of Global Public
Health, University of North Carolina, Chapel Hill, NC, USA.
(2)Division of Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy,
University of North Carolina, Chapel Hill, NC, USA.
(3)Health Literacy and Learning Program, Division of General Internal Medicine,
Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
(4)Department of Family Medicine, University of North Carolina, Chapel Hill, NC,
USA.
(5)Cecil G. Sheps Center for Health Services Research, University of North
Carolina, Chapel Hill, NC, USA.
(6)Program on Health Care and Prevention, Gillings School of Global Public
Health, University of North Carolina, Chapel Hill, NC, USA.
stacey_sheridan@med.unc.edu.
(7)Cecil G. Sheps Center for Health Services Research, University of North
Carolina, Chapel Hill, NC, USA. stacey_sheridan@med.unc.edu.
(8)Division of General Medicine and Clinical Epidemiology, Department of
Medicine, University of North Carolina, Chapel Hill, NC, USA.
stacey_sheridan@med.unc.edu.
(9)University of North Carolina at Chapel Hill, 5039 Old Clinic Building, CB
#7110, Chapel Hill, NC, 27599-7110, USA. stacey_sheridan@med.unc.edu.
Comment in
J Gen Intern Med. 2015 Oct;30(10):1537.
BACKGROUND: Health literacy (HL) and numeracy are measured by one of two methods:
performance on objective tests or self-report of one's skills. Whether results
from these methods differ in their relationship to health outcomes or use of
health services is unknown.
METHODS: We performed a systematic review to identify and evaluate articles that
measured both performance-based and self-reported HL or numeracy and examined
their relationship to health outcomes or health service use. To identify studies,
we started with an AHRQ-funded systematic review of HL and health outcomes. We
then looked for newer studies by searching MEDLINE from 1 February 2010 to 9
December 2014. We included English language studies meeting pre-specified
criteria. Two reviewers independently assessed abstracts and studies for
inclusion and graded study quality. One reviewer abstracted information from
included studies while a second checked content for accuracy.
RESULTS: We identified four "fair" quality studies that met inclusion criteria
for our review. Two studies measuring HL found no differences between
performance-based and self-reported HL for association with self-reported
outcomes (including diabetes, stroke, hypertension) or a physician-completed
rheumatoid arthritis disease activity score. However, HL measures were
differentially related to a patient-completed health assessment questionnaire and
to a patient's ability to interpret their prescription medication name and dose
from a medication bottle. Only one study measured numeracy and found no
difference between performance-based and self-reported measures of numeracy and
colorectal cancer (CRC) screening utilization. However, in a moderator analysis
from the same study, performance-based and self-reported numeracy were
differentially related to CRC screening utilization when stratified by certain
patient-provider communication behaviors (e.g., the chance to always ask
questions and get the support that is needed).
DISCUSSION: Most studies found no difference in the relationship between results
of performance-based and self-reported measures and outcomes. However, we
identified few studies using multiple instruments and/or objective outcomes.
DOI: 10.1007/s11606-015-3288-4
PMCID: PMC4579206
PMID: 25917656 [Indexed for MEDLINE]
Text Messaging May Engage and Benefit Adults with Type 2 Diabetes Regardless of
Health Literacy Status.
Author information:
(1)Senior Research Specialist, Center for Health Behavior and Health Education,
Vanderbilt University Medical Center.
(2)Research Assistant Professor, Center for Health Behavior and Health Education,
Vanderbilt University Medical Center.
(3)Professor of Medicine, and the Director, Center for Health Services Research,
Vanderbilt University Medical Center.
(4)Assistant Professor, Department of Medicine, Center for Health Behavior and
Health Education, Vanderbilt University Medical Center.
DOI: 10.3928/24748307-20170906-01
PMCID: PMC5714586
PMID: 29214241
Li LC(1), Shaw CD(2), Lacaille D(1), Yacyshyn E(3), Jones CA(3), Koehn C(4),
Hoens AM(1), Geldman J(5), Sayre EC(5), Macdonald GG(1), Leese J(1), Bansback
N(1).
Author information:
(1)University of British Columbia, Vancouver, Canada, and Arthritis Research
Canada, Richmond, Canada.
(2)Simon Fraser University, Burnaby, Canada.
(3)University of Alberta, Edmonton, Canada.
(4)Arthritis Consumer Experts, Vancouver, Canada.
(5)Arthritis Research Canada, Richmond, Canada.
DOI: 10.1002/acr.23287
PMID: 28544648 [Indexed for MEDLINE]
Treatment Outcomes From a Specialist Model for Treating Tobacco Use Disorder in a
Medical Center.
Burke MV(1), Ebbert JO, Schroeder DR, McFadden DD, Hays JT.
Author information:
(1)From the Nicotine Dependence Center, Department of Internal Medicine (MVB,
JOE, DDM, JTH) and Division of Biomedical Statistics and Informatics, Department
of Health Sciences Research, Mayo Clinic, Rochester, MN (DRS).
Cigarette smoking causes premature mortality and multiple morbidity; stop smoking
improves health. Higher rates of smoking cessation can be achieved through more
intensive treatment, consisting of medication and extended counseling of
patients, but there are challenges to integrating these interventions into
healthcare delivery systems. A care model using a master-level counselor trained
as a tobacco treatment specialist (TTS) to deliver behavioral intervention,
teamed with a supervising physician/prescriber, affords an opportunity to
integrate more intensive tobacco dependence treatment into hospitals, clinics,
and other medical systems. This article analyzes treatment outcomes and
predictors of abstinence for cigarette smokers being treated using the
TTS-physician team in a large outpatient clinic over a 7-year period.This is an
observational study of a large cohort of cigarette smokers treated for tobacco
dependence at a medical center. Patients referred by the primary healthcare team
for a TTS consult received a standard assessment and personalized treatment
planning guided by a workbook. Medication and behavioral plans were developed
collaboratively with each patient. Six months after the initial assessment, a
telephone call was made to ascertain a 7-day period of self-reported abstinence.
The univariate association of each baseline patient characteristic with
self-reported tobacco abstinence at 6 months was evaluated using the chi-squared
test. In addition, a multiple logistic regression analysis was performed with
self-reported tobacco abstinence as the dependent variable and all baseline
characteristics included as explanatory variables.Over a period of 7 years
(2005-2011), 6824 cigarette smokers who provided general research authorization
were seen for treatment. The 6-month self-reported abstinence rate was 28.1% (95%
confidence interval: 27.7-30.1). The patients most likely to report abstinence
were less dependent, more motivated to quit, and did not have a past year
diagnosis of depression or alcoholism.Predictable patient characteristics such as
level of dependence did predict abstinence, but all patient groups achieved
comparable abstinence outcomes. While this study has limitations inherent in a
single-center retrospective cohort study, it does suggest that the TTS model is
an effective way to integrate more intensive tobacco dependence treatment into
outpatient settings.
DOI: 10.1097/MD.0000000000001903
PMCID: PMC4915890
PMID: 26554789 [Indexed for MEDLINE]
Measuring health literacy among people living with HIV who attend a
community-based ambulatory clinic in Puerto Rico.
PMCID: PMC4394204
PMID: 25856875 [Indexed for MEDLINE]
Schaffer A(1)(2), Weinstock LM(3), Sinyor M(4)(5), Reis C(6), Goldstein BI(7)(8),
Yatham LN(9), Levitt AJ(4)(5).
Author information:
(1)Mood and Anxiety Disorders Program, Department of Psychiatry, Sunnybrook
Health Sciences Centre, 2075 Bayview Avenue, Room FG 52, Toronto, ON, M4N 3M5,
Canada. ayal.schaffer@sunnybrook.ca.
(2)Department of Psychiatry, University of Toronto, Toronto, Canada.
ayal.schaffer@sunnybrook.ca.
(3)Department of Psychiatry and Human Behavior, Brown University, Providence, RI,
USA.
(4)Department of Psychiatry, University of Toronto, Toronto, Canada.
(5)Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Canada.
(6)Mood and Anxiety Disorders Program, Department of Psychiatry, Sunnybrook
Health Sciences Centre, 2075 Bayview Avenue, Room FG 52, Toronto, ON, M4N 3M5,
Canada.
(7)Centre for Youth Bipolar Disorder, Department of Psychiatry, Sunnybrook Health
Sciences Centre, Toronto, Canada.
(8)Departments of Psychiatry and Pharmacology, University of Toronto, Toronto,
Canada.
(9)Department of Psychiatry, University of British Columbia, Vancouver, Canada.
OBJECTIVE: To characterize self-poisoning suicide deaths in BD compared to other
suicide decedents.
METHODS: Extracted coroner data from all suicide deaths (n = 3319) in Toronto,
Canada from 1998 to 2012. Analyses of demographics, clinical history, recent
stressors, and suicide details were conducted in 5 subgroups of suicide
decedents: BD self-poisoning, BD other methods, non-BD self-poisoning, non-BD
other methods, and unipolar depression self-poisoning. Toxicology results for
lethal and present substances were also compared between BD and non-BD
self-poisoning subgroups as well as between BD and unipolar depression
self-poisoning subgroups.
RESULTS: Among BD suicide decedents, self-poisoning was significantly associated
with female sex, past suicide attempts, and comorbid substance abuse. In both the
BD and non-BD self-poisoning groups, opioids were the most common class of lethal
medication. For both groups, benzodiazepines and antidepressants were the most
common medications present at time of death, and in 23% of the BD group, an
antidepressant was present without a mood stabilizer or antipsychotic. Only 31%
of the BD group had any mood stabilizer present, with carbamazepine being most
common. No antidepressant, mood stabilizer, or antipsychotic was present in 15.5%
of the BD group. Relative to unipolar depression self-poisoning group, the BD
self-poisoning group evidenced higher proportion of previous suicide attempt(s)
and psychiatry/ER visits in the previous week.
CONCLUSION: People with BD who die by suicide via self-poisoning comprise a
distinct but understudied group. The predominant absence of guideline-concordant
pharmacologic care comprises a crucial target for future policy and knowledge
translation efforts.
DOI: 10.1186/s40345-017-0081-9
PMCID: PMC5406320
PMID: 28332123
Bailey SC(1), Wismer GA(2), Parker RM(3), Walton SM(4), Wood AJJ(5), Wallia A(6),
Brokenshire SA(7), Infanzon AC(7), Curtis LM(2), Kwasny MJ(8), Wolf MS(2).
Author information:
(1)Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of
Pharmacy, University of North Carolina, Chapel Hill, NC, United States.
Electronic address: scbailey@unc.edu.
(2)Health Literacy and Learning Program, Division of General Internal Medicine &
Geriatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL,
United States.
(3)Department of Medicine, Emory University School of Medicine, Atlanta, GA,
United States.
(4)Department of Pharmacy Systems Outcomes and Policy, College of Pharmacy,
University of Illinois at Chicago, Chicago, IL, United States.
(5)Department of Medicine, Division of Clinical Pharmacology, Vanderbilt
University School of Medicine, Nashville, TN, United States.
(6)Division of Endocrinology, Metabolism, and Molecular Medicine, Department of
Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL,
United States.
(7)Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of
Pharmacy, University of North Carolina, Chapel Hill, NC, United States.
(8)Department of Preventive Medicine, Feinberg School of Medicine, Northwestern
University, Chicago, IL, United States.
DOI: 10.1016/j.cct.2017.08.013
PMCID: PMC5641260
PMID: 28823927 [Indexed for MEDLINE]
Polypharmacy and risk of falls and fractures for patients with HIV infection and
substance dependence.
Kim TW(1), Walley AY(1), Ventura AS(1), Patts GJ(2), Heeren TC(3), Lerner GB(4),
Mauricio N(4), Saitz R(1)(5).
Author information:
(1)a Clinical Addiction Research and Education (CARE) Unit, Section of General
Internal Medicine, Boston Medical Center , Boston University School of Medicine ,
Boston , MA , USA.
(2)b Data Coordinating Center , Boston University School of Public Health ,
Boston , MA , USA.
(3)c Department of Biostatistics , Boston University School Public Health ,
Boston , MA , USA.
(4)d Boston University School of Medicine , Boston , MA , USA.
(5)e Department of Community Health Sciences , Boston University School of Public
Health , Boston , MA , USA.
Although people with HIV infection (PLWH) are at higher risk of polypharmacy and
substance use, there is limited knowledge about potential harms associated with
polypharmacy such as falls and fractures in this population. The study objective
was to determine whether polypharmacy, as measured by the number and type of
medication, is associated with falls and fractures among PLWH and DSM-IV
substance dependence in the past year or ever injection drug use (IDU). We
identified the number of medications by electronic medical record review in the
following categories: (i) systemically active, (ii) non-antiretroviral (non-ARV),
(iii) sedating, (iv) non-sedating as well as any opioid medication and any
non-opioid sedating medication. Outcomes were self-reported (1) fall/accident
requiring medical attention and (2) fracture in the previous year. Separate
logistic regression models were fitted for medications in each category and each
outcome. Among 250 participants, the odds of a fall requiring medical attention
were higher with each additional medication overall (odds ratio [OR] 1.12, 95%
Confidence Interval [CI] = 1.05, 1.18), each additional non-ARV medication (OR
1.13, 95%CI = 1.06, 1.20), each additional sedating medication (OR 1.36,
95%CI = 1.14, 1.62), and a non-opioid sedating medication (OR 2.89, 95%CI = 1.06,
7.85) but not with an additional non-sedating medication or opioid medication. In
receiver operating characteristic (ROC) curve analyses, optimal cutoffs for
predicting falls were: ≥8 overall and ≥2 sedating medications. Odds ratios for
fracture in the previous year were OR 1.05, 95%CI = 0.97, 1.13 for each
additional medication overall and OR 1.11, 95%CI = 0.89, 1.38 for each additional
sedating medication. In PLWH and substance dependence or ever IDU, a higher
number of medications was associated with greater odds of having a fall requiring
medical attention. The association appeared to be driven largely by sedating
medications. Future studies should determine if reducing such polypharmacy,
particularly sedating medications, lowers the risk of falls.
DOI: 10.1080/09540121.2017.1384532
PMCID: PMC5977400
PMID: 29034725 [Indexed for MEDLINE]
Booth R(1), Sinclair B(#)(1), McMurray J(2), Strudwick G(3), Watson G(4), Ladak
H(5), Zwarenstein M(6), McBride S(7), Chan R(1), Brennan L(1).
Author information:
(1)Arthur Labatt Family School of Nursing, Faculty of Health Sciences, Western
University, London, ON, Canada.
(2)Business Technology Management/Health Studies, Wilfrid Laurier University,
Waterloo, ON, Canada.
(3)Information Management Group, Centre for Addiction and Mental Health, Toronto,
ON, Canada.
(4)Teaching Support Centre, Western University, London, ON, Canada.
(5)Department of Medical Biophysics, Faculty of Engineering, Western University,
London, ON, Canada.
(6)Centre for Studies in Family Medicine, Schulich School of Medicine and
Dentistry, Western University, London, ON, Canada.
(7)School of Nursing, Texas Tech University Health Sciences Center, Lubbock, TX,
United States.
(#)Contributed equally
DOI: 10.2196/resprot.9601
PMCID: PMC5996180
PMID: 29807885
Okokon EO(1), Yli-Tuomi T(2), Turunen AW(3), Tiittanen P(4), Juutilainen J(5),
Lanki T(6).
Author information:
(1)Department of Health Protection, THL - National Institute for Health and
Welfare, P.O. Box 95, FI-70701 Kuopio, Finland. Electronic address:
enembe.okokon@thl.fi.
(2)Department of Health Protection, THL - National Institute for Health and
Welfare, P.O. Box 95, FI-70701 Kuopio, Finland. Electronic address:
tarja.yli-tuomi@thl.fi.
(3)Department of Health Protection, THL - National Institute for Health and
Welfare, P.O. Box 95, FI-70701 Kuopio, Finland. Electronic address:
anu.turunen@thl.fi.
(4)Department of Health Protection, THL - National Institute for Health and
Welfare, P.O. Box 95, FI-70701 Kuopio, Finland. Electronic address:
pekka.tiittanen@thl.fi.
(5)Department of Environmental Sciences, University of Eastern Finland,
Yliopistonranta 1, FI-70210 Kuopio, Finland. Electronic address:
jukka.juutilainen@uef.fi.
(6)Department of Health Protection, THL - National Institute for Health and
Welfare, P.O. Box 95, FI-70701 Kuopio, Finland; School of Medicine, University of
Eastern Finland, Yliopistonranta 1, FI-70210 Kuopio, Finland. Electronic address:
timo.lanki@thl.fi.
BACKGROUND: Road-traffic noise can induce stress, which may contribute to mental
health disorders. Mental health problems have not received much attention in
noise research. People perceive noise differently, which may affect the extent to
which noise contributes to poor mental health at the individual level. This paper
aims to assess the relationships between outdoor traffic noise and noise
annoyance and the use of psychotropic medication.
METHODS: We conducted a survey to assess noise annoyance and psychotropic
medication among residents of the Helsinki Capital Region of Finland. We also
assessed the associations of annoyance and road-traffic noise with sleep
disorders, anxiety and depression. Respondents were randomly sampled from the
Finnish Population registry, and data was collected using a self-administered
questionnaire. Outdoor traffic noise was modelled using the Nordic prediction
model. Associations between annoyance and modelled façade-noise levels with
mental health outcome indicators were assessed using a binary logistic regression
while controlling for socioeconomic, lifestyle and exposure-related factors.
RESULTS: A total of 7321 respondents returned completed questionnaires. Among the
study respondents, 15%, 7% and 7% used sleep medication, anxiolytic and
antidepressant medications, respectively, in the year preceding the study. Noise
annoyance was associated with anxiolytic drug use, OR = 1.41 (95% CI: 1.02-1.95),
but not with sedative or antidepressant use. There was suggestive association
between modelled noise at levels higher than 60 dB and anxiolytic or
antidepressant use. In respondents whose bedroom windows faced the street,
modelled noise was definitively associated with antidepressant use. Noise
sensitivity did not modify the effect of noise but was associated with an
increased use of psychotropic medication.
CONCLUSION: We observed suggestive associations between high levels of
road-traffic noise and psychotropic medication use. Noise sensitivity was
associated with psychotropic medication use.
Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.envint.2018.06.034
PMID: 29990948 [Indexed for MEDLINE]
Author information:
(1)Department of Medicine, Vanderbilt University Medical Center, Nashville, TN,
USA; Center for Health Behavior and Health Education, Vanderbilt University
Medical Center, Nashville, TN, USA.
(2)School of Nursing, Vanderbilt University, Nashville, TN, USA; Center for
Health Services Research, Vanderbilt University Medical Center, Nashville, TN,
USA.
(3)Department of Medicine, Vanderbilt University Medical Center, Nashville, TN,
USA; Center for Clinical Quality and Implementation Research, Vanderbilt
University Medical Center, Nashville, TN, USA.
(4)Department of Medicine, Vanderbilt University Medical Center, Nashville, TN,
USA; Center for Health Behavior and Health Education, Vanderbilt University
Medical Center, Nashville, TN, USA; Center for Clinical Quality and
Implementation Research, Vanderbilt University Medical Center, Nashville, TN,
USA. Electronic address: lindsay.mayberry@vanderbilt.edu.
DOI: 10.1016/j.diabres.2018.05.046
PMCID: PMC6083841
PMID: 29879495 [Indexed for MEDLINE]
1865. Ann Intern Med. 2014 Nov 18;161(10 Suppl):S13-22. doi: 10.7326/M13-3012.
DOI: 10.7326/M13-3012
PMCID: PMC4391371
PMID: 25402398 [Indexed for MEDLINE]
Pilot study to test the feasibility of a trial design and complex intervention on
PRIoritising MUltimedication in Multimorbidity in general practices
(PRIMUMpilot).
Muth C(1), Harder S(2), Uhlmann L(3), Rochon J(3), Fullerton B(1), Güthlin C(1),
Erler A(1), Beyer M(1), van den Akker M(4), Perera R(5), Knottnerus A(6),
Valderas JM(7), Gerlach FM(1), Haefeli WE(8).
Author information:
(1)Institute of General Practice, Johann Wolfgang Goethe University,
Frankfurt/Main, Germany.
(2)Institute for Clinical Pharmacology, Johann Wolfgang Goethe University
Hospital, Frankfurt/Main, Germany.
(3)Institute of Medical Biometry and Informatics, University of Heidelberg,
Heidelberg, Germany.
(4)Institute of General Practice, Johann Wolfgang Goethe University,
Frankfurt/Main, Germany Department of Family Medicine, School CAPHRI, Maastricht
University, Maastricht, The Netherlands Department of General Practice, KU
Leuven, Leuven, Belgium.
(5)Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
(6)Department of Family Medicine, School CAPHRI, Maastricht University,
Maastricht, The Netherlands.
(7)Health Services & Policy Research Group, School of Medicine, University of
Exeter, Exeter, UK.
(8)Department of Clinical Pharmacology and Pharmacoepidemiology, University of
Heidelberg, Heidelberg, Germany.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://www.bmj.com/company/products-services/rights-and-licensing/
DOI: 10.1136/bmjopen-2016-011613
PMCID: PMC4964238
PMID: 27456328 [Indexed for MEDLINE]
Author information:
(1)Department of Clinical Pharmacy, University of Bonn, An der Immenburg 4,
53121, Bonn, Germany. rose@elefantenapo.de.
(2)Elefanten-Apotheke gegr 1575, Steinstr. 14, 48565, Steinfurt, Germany.
rose@elefantenapo.de.
(3)Centre of Health Care Management and Public Health, Schumpeter School of
Business and Economics, University of Wuppertal, Wuppertal, Germany.
Schaffert@wiwi.uni-wuppertal.de.
(4)Centre of Health Care Management and Public Health, Schumpeter School of
Business and Economics, University of Wuppertal, Wuppertal, Germany.
CzarneckiK@wiwi.uni-wuppertal.de.
(5)Muenster University of Applied Science, Robert-Koch-Str. 30, 48149, Muenster,
Germany. h.mennemann@fh-muenster.de.
(6)Department of Pharmacy, University of Muenster, Corrensstr. 48, 48149,
Muenster, Germany. waltering@pharmd.de.
(7)Institute of Medical Statistics, Informatics and Epidemiology, University of
Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
stefanie.hamacher@uni-koeln.de.
(8)Institute of Medical Statistics, Informatics and Epidemiology, University of
Cologne, Kerpener Str. 62, 50937, Cologne, Germany. moritz.felsch@uni-koeln.de.
(9)Institute of Medical Statistics, Informatics and Epidemiology, University of
Cologne, Kerpener Str. 62, 50937, Cologne, Germany. lena.herich@uni-koeln.de.
(10)Centre of Health Care Management and Public Health, Schumpeter School of
Business and Economics, University of Wuppertal, Wuppertal, Germany.
koeberlein@wiwi.uni-wuppertal.de.
DOI: 10.1186/s12875-015-0305-y
PMCID: PMC4508809
PMID: 26198433 [Indexed for MEDLINE]
Author information:
(1)Research Center for Environmental Determinants of Health (ECEDH), Public
Health School, Kermanshah University of Medical Sciences, Kermanshah, Iran.
(2)Modeling in Health Research Center, Institute for Future Studies in Health,
Kerman University of Medical Science, Kerman, Iran.
DOI: 10.29252/beat-070202.
PMCID: PMC6555204
PMID: 31198796
DOI: 10.3389/fpubh.2017.00256
PMCID: PMC5632356
PMID: 29043247
Fishbein JN(1), Nisotel LE(2), MacDonald JJ(3), Amoyal Pensak N(4), Jacobs
JM(5)(6), Flanagan C(7)(8), Jethwani K(7)(9), Greer JA(5)(6).
Author information:
(1)Department of Psychology and Neuroscience, University of Colorado Boulder,
Boulder, CO, United States.
(2)Department of Epidemiology, Harvard TH Chan School of Public Health, Boston,
MA, United States.
(3)Department of Psychology, University of California, Los Angeles, Los Angeles,
CA, United States.
(4)Anschutz Medical Campus, Department of Medicine, University of Colorado
Denver, Denver, CO, United States.
(5)Center for Psychiatric Oncology and Behavioral Sciences, Massachusetts General
Hospital and Harvard Medical School, Boston, MA, United States.
(6)Department of Psychiatry, Massachusetts General Hospital and Harvard Medical
School, Boston, MA, United States.
(7)Partners Connected Health, Partners HealthCare, Boston, MA, United States.
(8)Department of Global Health and Population, Harvard TH Chan School of Public
Health, Boston, MA, United States.
(9)Department of Dermatology, Massachusetts General Hospital and Harvard Medical
School, Boston, MA, United States.
©Joel Nathan Fishbein, Lauren Ellen Nisotel, James John MacDonald, Nicole Amoyal
Pensak, Jamie Michele Jacobs, Clare Flanagan, Kamal Jethwani, Joseph Andrew
Greer. Originally published in JMIR Research Protocols
(http://www.researchprotocols.org), 20.04.2017.
DOI: 10.2196/resprot.6198
PMCID: PMC5418526
PMID: 28428158
1871. Drug Saf. 2019 Jan;42(1):1-12. doi: 10.1007/s40264-018-0722-7.
Vorstenbosch S(1), Te Winkel B(2), van Gelder MMHJ(3)(4), Kant A(2), Roeleveld
N(3), van Puijenbroek E(2)(5).
Author information:
(1)Netherlands Pharmacovigilance Centre Lareb, Goudsbloemvallei 7, 5237 MH,
's-Hertogenbosch, The Netherlands. s.vorstenbosch@lareb.nl.
(2)Netherlands Pharmacovigilance Centre Lareb, Goudsbloemvallei 7, 5237 MH,
's-Hertogenbosch, The Netherlands.
(3)Department for Health Evidence, Radboud Institute for Health Sciences, Radboud
University Medical Center, Nijmegen, The Netherlands.
(4)Radboud REshape Innovation Center, Radboud University Medical Center,
Nijmegen, The Netherlands.
(5)PharmacoTherapy, -Epidemiology and -Economics, Groningen Research Institute of
Pharmacy, University of Groningen, Groningen, The Netherlands.
DOI: 10.1007/s40264-018-0722-7
PMCID: PMC6373399
PMID: 30246225 [Indexed for MEDLINE]
Tütüncü EE(1), Güner R(2), Gürbüz Y(1), Kaya Kalem A(3), Öztürk B(1), Hasanoğlu
İ(3), Şencan İ(1), Taşyaran MA(2).
Author information:
(1)Department of Infectious Diseases and Clinical Microbiology, University of
Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara,
Turkey.
(2)Department of Infectious Diseases and Clinical Microbiology, Ankara Yıldırım
Beyazıt University School of Medicine, Ankara, Turkey.
(3)Clinic of Infectious Diseases and Clinical Microbiology, Ankara Atatürk
Training and Research Hospital, Ankara, Turkey.
DOI: 10.4274/balkanmedj.2016.1461
PMCID: PMC5785659
PMID: 29215337 [Indexed for MEDLINE]
Author information:
(1)Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical
University, Wroclaw, Poland.
(2)Department of Logistic and Transport Systems, Faculty of Mechanical
Engineering, Wroclaw University of Technology, Wroclaw, Poland.
(3)Department of Community Health Sciences, UCLA Fielding School of Public
Health, Los Angeles, CA, USA.
(4)Department of Internal Medicine, Occupational Diseases and Hypertension,
Wroclaw Medical University, Wroclaw, Poland.
DOI: 10.2147/PPA.S101904
PMCID: PMC5026177
PMID: 27672314
Willeboordse F(1), Hugtenburg JG, van Dijk L, Bosmans JE, de Vries OJ, Schellevis
FG, Elders PJ.
Author information:
(1)NIVEL, Netherlands Institute for Health Services Research, Po, Box 1568, 3500
BN, Utrecht, The Netherlands. f.willeboordse@vumc.nl.
BACKGROUND: Inappropriate drug use has been identified as one of the most
important problems affecting the quality of care in older people. Inappropriate
drug use may increase the risk of the occurrence of 'geriatric giants' such as
immobility, instability, incontinence and cognitive impairment. There are
indications that clinical medication reviews (CMR) can reduce inappropriate drug
use. However, CMRs have not yet been implemented at a large scale in primary
care. An innovative medication review program in primary care will be developed
which tackles the most important obstacles for a large scale implementation of
CMRs. The aim of this study is to assess whether this CMR program is (cost-)
effective compared with usual general practice care for older patients with
geriatric symptoms with regard to quality of life and geriatric symptoms.
METHODS: A cluster randomised controlled trial will be performed in 20 Dutch
general practices including 500 patients. Patients of 65 years and older are
eligible if they newly present with pre-specified geriatric symptoms in general
practice and chronic use of at least one prescribed drug. GP practices will be
stratified by practice size and randomly allocated to control (n = 10) or
intervention group (n = 10). The intervention consists of CMRs which will be
facilitated and prepared by an expert team consisting of a GP and a pharmacist.
Primary outcome measures are patient's quality of life and the presence of
self-reported geriatric symptoms during a follow-up period of 6 months. Secondary
outcomes are costs of healthcare utilisation, feasibility, number of drug related
problems, medication adherence and satisfaction with medication.
DISCUSSION: This study is expected to add evidence on the (cost-) effectiveness
of an optimally facilitated, prepared and structured CMR in comparison with usual
care in older patients who present a geriatric symptom to their GP. The strength
of this study is that it will be conducted in daily clinical practice. This
improves the possibilities to implement the CMRs in the primary care setting on a
large scale.
TRIAL REGISTRATION: Netherlands Trial register: NTR4264.
DOI: 10.1186/1471-2318-14-116
PMCID: PMC4240827
PMID: 25407349 [Indexed for MEDLINE]
Zanarini MC(1), Frankenburg FR, Bradford Reich D, Harned AL, Fitzmaurice GM.
Author information:
(1)From the *Department of Psychiatry, McLean Hospital, Belmont; †Department of
Psychiatry, Harvard Medical School; and ‡Department of Psychiatry, Boston
University School of Medicine, Boston, MA.
The purpose of this study was to assess the classes and types of psychotropic
medication reported by borderline patients and axis II comparison subjects over
16 years of prospective follow-up. Medication use was assessed at baseline using
a semistructured interview of proven reliability and validity as well as its
follow-up analog at 8 contiguous 2-year follow-up periods. A significantly higher
percentage of borderline patients than axis II comparison subjects reported
taking an antidepressant, an anxiolytic, an antipsychotic, and a mood stabilizer
over time. They also reported more commonly taking 7 of the 10 more specific
types of medication studied (ie, all but tricyclic antidepressants, monoamine
oxidase inhibitor antidepressants, and atypical antipsychotics). The rates over
time of taking antipsychotics and mood stabilizers were stable, whereas there was
a significant decline in the rates of antidepressants and anxiolytics from
baseline to 8-year follow-up (but not from 8- to 16-year follow-up) reported by
those in both study groups. In terms of specific medications, rates of atypical
antidepressants and anticonvulsants were the most stable. In contrast,
nonbenzodiazepine anxiolytics declined the most steadily over time, whereas rates
of atypical antipsychotics increased significantly over the 16 years of
prospective follow-up. Taken together, the results of this study suggest that a
substantial percentage of borderline patients continue to use the major classes
of medication over time. They also suggest that the declining rates of use tend
to stabilize less than a decade after index admission.
DOI: 10.1097/JCP.0000000000000232
PMCID: PMC4276426
PMID: 25384261 [Indexed for MEDLINE]
Older adults recently started on psychotropic medication: where are the symptoms?
Maust DT(1), Chen SH, Benson A, Mavandadi S, Streim JE, DiFilippo S, Snedden TM,
Oslin DW.
Author information:
(1)Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA; Center
for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, MI,
USA.
DOI: 10.1002/gps.4187
PMID: 25116369 [Indexed for MEDLINE]
1877. Spinal Cord Ser Cases. 2017 Nov 30;3:17083. doi: 10.1038/s41394-017-0032-9.
eCollection 2017.
Author information:
(1)1The University of Buckingham Medical School, Hunter Street, Buckingham, MK18
1EG UK.
(2)2The Department of Psychology, The University of Buckingham, Hunter Street,
Buckingham, MK18 1EG UK.
(3)3The National Spinal Injuries Centre, Stoke Mandeville Hospital, Aylesbury,
HP21 8AL UK.
DOI: 10.1038/s41394-017-0032-9
PMCID: PMC5798930
PMID: 29423289
Paton C(1), Bhatti S(2), Purandare K(3), Roy A(4), Barnes T(5).
Author information:
(1)Oxleas NHS Foundation Trust, Dartford, UK.
(2)Royal College of Psychiatrists Centre for Quality Improvement, London, UK.
(3)Central and North East London Foundation Trust, London, UK.
(4)Coventry and Warwickshire Partnership Trust, Coventry, UK.
(5)Imperial College, London, UK.
Published by the BMJ Publishing Group Limited. For permission to use (where not
already granted under a licence) please go to
http://www.bmj.com/company/products-services/rights-and-licensing/.
DOI: 10.1136/bmjopen-2016-013116
PMCID: PMC5168692
PMID: 27920085 [Indexed for MEDLINE]
Jongen PJ(1), Sinnige LG(2), van Geel BM(3), Verheul F(4), Verhagen WI(5), van
der Kruijk RA(6), Haverkamp R(7), Schrijver HM(8), Baart JC(9), Visser LH(10),
Arnoldus EP(11), Gilhuis HJ(12), Pop P(13), Booy M(14), Heerings M(15), Kool
A(16), van Noort E(16).
Author information:
(1)Department of Community and Occupational Medicine, University Medical Center
Groningen, University of Groningen, Groningen, the Netherlands; MS4 Research
Institute, Nijmegen, the Netherlands.
(2)Multiple Sclerosis Centre Leeuwarden, Medical Centre Leeuwarden, Leeuwarden,
the Netherlands.
(3)Department of Neurology, Medical Centre Alkmaar, Alkmaar, the Netherlands.
(4)Department of Neurology, Groene Hart Hospital, Gouda, the Netherlands.
(5)Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, the
Netherlands.
(6)Department of Neurology, Slingeland Hospital, Doetinchem, the Netherlands.
(7)Department of Neurology, Zuwe Hofpoort Hospital, Woerden, the Netherlands.
(8)Multiple Sclerosis Centre, Westfries Gasthuis, Hoorn, the Netherlands.
(9)Department of Neurology, Ziekenhuisgroep Twente, Almelo-Hengelo, the
Netherlands.
(10)Multiple Sclerosis Centre Midden Brabant, St Elisabeth Hospital, Tilburg, the
Netherlands.
(11)Multiple Sclerosis Centre Midden Brabant, Tweesteden Hospital, Delft, the
Netherlands.
(12)Department of Neurology, Reinier de Graaf Gasthuis, Delft, the Netherlands.
(13)Department of Neurology, Viecuri Medical Centre, Venlo-Venray, the
Netherlands.
(14)Multiple Sclerosis Centre, Amphia Hospital, Breda, the Netherlands.
(15)MH Advies en organisatiebureau, Assen, the Netherlands.
(16)Curavista bv, Geertruidenberg, the Netherlands.
DOI: 10.2147/PPA.S93786
PMCID: PMC4780403
PMID: 27042018
Author information:
(1)San Miguel Health Center, Costa del Sol Primary Healthcare District,
Andalusian Health Service, Málaga, Spain.
(2)North Málaga Health Area, Andalusian Health Service, Málaga, Spain.
(3)La Roca Health Center, Málaga-Guadalhorce Primary Healthcare District,
Andalusian Health Service, Málaga, Spain.
(4)Costa del Sol Health Agency, Andalusian Health Service, Marbella (Málaga),
Spain.
(5)Campillo Health Center, North Málaga Health Area, Andalusian Health Service,
Málaga, Spain.
(6)Department of Pharmacology, Biomedical Research Institute of Málaga.
University of Málaga, Málaga, Spain.
DOI: 10.1371/journal.pone.0171320
PMCID: PMC5293190
PMID: 28166266 [Indexed for MEDLINE]
1881. Alcohol Clin Exp Res. 2018 Jul;42(7):1249-1259. doi: 10.1111/acer.13772. Epub
2018 Jun 9.
Author information:
(1)Department of Psychology, University of New Mexico, Albuquerque, New Mexico.
(2)Center on Alcoholism, Substance Abuse, and Addictions, University of New
Mexico, Albuquerque, New Mexico.
(3)Center for Studies of Addiction, University of Pennsylvania Perelman School of
Medicine, Philadelphia, Pennsylvania.
BACKGROUND: Alcohol is often consumed with opioids and alcohol misuse interferes
with treatment for opioid use disorder (OUD). Drug misuse is associated with
worse alcohol use disorder (AUD) treatment outcomes, yet no studies have
investigated the role of opioid misuse in AUD treatment outcomes.
METHODS: We conducted secondary analyses of the medication conditions of the
COMBINE study (n = 1,226), a randomized clinical trial of medications
(acamprosate and/or naltrexone) and behavioral interventions (medication
management and/or behavioral intervention) for alcohol dependence. We examined
associations between baseline opioid misuse and the use of cannabis and other
drugs with time to first drinking day, time to first heavy drinking day, and the
frequency and intensity of drinking during treatment and 1 year following
treatment, based on latent profile analysis. Opioid misuse was defined as use of
illicit or prescription opioids without a prescription or not as directed in the
previous 6 months, in the absence of OUD. Self-reported cannabis and other drug
use were also examined. Seventy individuals (5.7%) met the opioid misuse
definition and 542 (44.2%) reported use of cannabis or other drugs without opioid
misuse. We also examined medication adherence as a potential mediator.
RESULTS: Baseline opioid misuse significantly predicted the time to first heavy
drinking day (OR = 1.38 [95% CI: 1.13, 1.64], p = 0.001) and a higher probability
of being in a heavier and more frequent drinking profile at the end of treatment
(OR = 2.90 [95% CI: 1.43, 5.90], p = 0.003), and at 1 year following treatment
(OR = 2.66 [95% CI: 1.26, 5.59], p = 0.01). Cannabis and other drug use also
predicted outcomes. Medication adherence partially mediated the association
between opioid misuse, cannabis use, other drug use, and treatment outcomes.
CONCLUSIONS: Opioid misuse and other drug use were associated with poorer AUD
treatment outcomes, which was partially mediated by medication adherence.
Clinicians and researchers should assess opioid misuse and other drug use in
patients undergoing AUD treatment.
DOI: 10.1111/acer.13772
PMCID: PMC6063524
PMID: 29873089
Robinson-Papp J(1), George MC(2), Wongmek A(2), Nmashie A(2), Merlin JS(3), Ali
Y(4), Epstein L(5), Green M(2), Serban S(5), Sheth P(6), Simpson DM(2).
Author information:
(1)Department of Neurology, Icahn School of Medicine at Mount Sinai, New York,
New York, USA. Electronic address: jessica.robinson-papp@mssm.edu.
(2)Department of Neurology, Icahn School of Medicine at Mount Sinai, New York,
New York, USA.
(3)Department of Medicine, University of Alabama at Birmingham, Birmingham,
Alabama, USA.
(4)Department of Rheumatology, Icahn School of Medicine at Mount Sinai, New York,
New York, USA.
(5)Department of Anesthesiology, Icahn School of Medicine at Mount Sinai, New
York, New York, USA.
(6)Department of Rehabilitation Medicine, Icahn School of Medicine at Mount
Sinai, New York, New York, USA.
CONTEXT: The extent to which patients take chronic pain medications as prescribed
is not well studied, and there are no generally agreed-upon measures. The
Quantitative Analgesic Questionnaire (QAQ) is a new instrument designed to
comprehensively document patient-reported medication use, generate scores to
quantify it (by individual drug, class, and/or overall), and compare it
(qualitatively and/or quantitatively) to the regimen as prescribed.
OBJECTIVES: The aim of this study was to describe the development and preliminary
validation of the QAQ.
METHODS: The QAQ was studied in a convenience sample of 149 HIV-infected
participants.
RESULTS: We found that the QAQ scores computed for participants' chronic pain
medication regimens were valid based on their correlation with 1)
patient-reported pain intensity (r = 0.38; P < 0.001) and 2) experienced pain
management physicians' independent quantification of the regimens (r = 0.89;
P < 0.001). The QAQ also demonstrated high interrater reliability (r = 0.957;
P < 0.001). Detailed examination of the QAQ data in a subset of 34 participants
demonstrated that the QAQ revealed suboptimal adherence in 44% of participants
and contained information that would not have been gleaned from review of the
medical record alone in 94%, including use of over-the-counter medications and
quantification of "as needed" dosing. The QAQ also was found to be useful in
quantifying change in the medication regimen over time, capturing a change in 50%
of the participants from baseline to eight week follow-up.
CONCLUSION: The QAQ is a simple tool that can facilitate understanding of
patient-reported chronic pain medication regimens, including calculation of
percent adherence and generation of quantitative scores suitable for estimating
and tracking change in medication use over time.
DOI: 10.1016/j.jpainsymman.2015.03.013
PMCID: PMC4550505
PMID: 25912277 [Indexed for MEDLINE]
Author information:
(1)Group of Clinical and Experimental Allergy, IPS Universitaria, University of
Antioquia, Medellin, Colombia.
(2)Foundation for the Development of Medical and Biological Sciences (FUNDEMEB),
Cartagena, Colombia.
(3)Faculty of Medicine, Corporation University Rafael Nunez, Cartagena, Colombia.
BACKGROUND AND OBJECTIVE: Many patients with chronic spontaneous urticaria (CSU)
report various drugs as triggers of their symptoms and often avoid medication
unnecessarily. Objective: To estimate the clinical impact of the drugs patients
most frequently suspect of inducing CSU exacerbations.
METHODS: The prevalence of self-reported drug reactions was evaluated by
questioning patients about their clinical history of urticaria and drug reactions
and performing challenge tests with the suspect drugs. A group of healthy persons
were included as controls to evaluate the prevalence of self-reported drug
reactions.
RESULTS: The study population comprised 245 patients with CSU and 127 healthy
individuals. At least 1 adverse drug reaction was reported by 92 (37.5%) patients
and 30 (23.6%) controls. Nonsteroidal anti-inflammatory drugs (NSAIDs) (27.7%)
and ß-lactams (9.4%) were the most commonly reported drugs in the CSU group and
the control group, respectively. Positive results in the challenge tests were
less common than self-reports in the CSU group (13%) and the control group
(0.7%).
CONCLUSIONS: Self-reporting is generally not sufficient to confirm a drug
reaction. Drug reactions to NSAIDs and ß-lactams are more frequent among patients
who experience CSU than in those who do not. Drug challenge tests should be
offered early during medical evaluation to avoid unnecessary restrictions.
DOI: 10.18176/jiaci.0287
PMID: 29956666 [Indexed for MEDLINE]
"My friend who bought it for me, she has had an abortion before." The influence
of Ghanaian women's social networks in determining the pathway to induced
abortion.
Author information:
(1)Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor,
MI, USA.
(2)Department of Health Behavior and Biological Sciences, University of Michigan
School of Nursing, Ann Arbor, MI, USA.
(3)Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
BACKGROUND: Even given the liberal abortion law in Ghana, abortion complications
are a large contributor to maternal morbidity and mortality. This study sought to
understand why young women seeking an abortion in a legally enabling environment
chose to do this outside the formal healthcare system.
METHODS: Women being treated for complications arising from a self-induced
abortion as well as for elective abortions at three hospitals in Ghana were
interviewed. Community-based focus groups were held with women as well as men,
separately. Interviews and focus group discussions were conducted until
saturation was reached.
RESULTS: A total of 18 women seeking care for complications from a self-induced
abortion and 11 seeking care for an elective abortion interviewed. The women
ranged in age from 13 to 35 years. There were eight focus groups; two with men
and six with women. The reasons women self-induce are: (1) abortion is illegal;
(2) attitudes of the healthcare workers; (3) keeping the pregnancy a secret; and
(4) social network influence. The meta-theme of normalisation of self-inducing'
an abortion was identified.
DISCUSSION: When women are faced with an unplanned and unwanted pregnancy, they
consult individuals in their social network whom they know have dealt with a
similar situation. Misoprostol is widely available in Ghanaian cities and is
successful at inducing an abortion for many women. In this way, self-inducing
abortions using medication procured from pharmacists and chemical sellers has
become normalised for women in Kumasi, Ghana.
DOI: 10.1136/jfprhc-2016-101502
PMID: 28330856
Conaghan PG(1), Serpell M(2), McSkimming P(3), Junor R(4), Dickerson S(5)(6).
Author information:
(1)Leeds Institute of Rheumatic and Musculoskeletal Medicine and National
Institute of Health Research (NIHR) Leeds Musculoskeletal Biomedical Research
Unit, University of Leeds, Leeds, UK.
(2)University Department of Anaesthesia, Gartnavel General Hospital, Glasgow, UK.
(3)Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
(4)Napp Pharmaceuticals Limited, Cambridge, UK.
(5)Napp Pharmaceuticals Limited, Cambridge, UK. Sara.Dickerson@mundipharma.co.uk.
(6)Mundipharma International Limited, Cambridge Science Park, Milton Road,
Cambridge, CB4 0GW, UK. Sara.Dickerson@mundipharma.co.uk.
DOI: 10.1007/s40271-016-0181-0
PMCID: PMC4925685
PMID: 27314487 [Indexed for MEDLINE]
Venkataraman K(1), Khoo C(2), Wee HL(3), Tan CS(1), Ma S(4), Heng D(4), Lee J(1),
Tai ES(2), Thumboo J(5).
Author information:
(1)Saw Swee Hock School of Public Health, National University of Singapore and
National University Health System, Singapore, Singapore.
(2)Department of Medicine, Yong Loo Lin School of Medicine, National University
of Singapore and National University Health System, Singapore, Singapore.
(3)Department of Pharmacy, National University of Singapore, Singapore,
Singapore; Department of Rheumatology & Immunology, Singapore General Hospital,
Singapore, Singapore.
(4)Epidemiology and Disease Control Division, Ministry of Health, Singapore,
Singapore.
(5)Department of Medicine, Yong Loo Lin School of Medicine, National University
of Singapore and National University Health System, Singapore, Singapore;
Department of Rheumatology & Immunology, Singapore General Hospital, Singapore,
Singapore.
DOI: 10.1371/journal.pone.0113802
PMCID: PMC4245227
PMID: 25426951 [Indexed for MEDLINE]
Gryczynski J(1), McNeely J(2), Wu LT(3), Subramaniam GA(4), Svikis DS(5), Cathers
LA(5), Sharma G(6), King J(6), Jelstrom E(6), Nordeck CD(7), Sharma A(7),
Mitchell SG(7), O'Grady KE(8), Schwartz RP(7).
Author information:
(1)Friends Research Institute, 1040 Park Avenue, Suite 103, Baltimore, MD, 21201,
USA. jgryczynski@friendsresearch.org.
(2)New York University School of Medicine, New York, NY, USA.
(3)Duke University School of Medicine, Durham, NC, USA.
(4)Center for Clinical Trials Network, National Institute on Drug Abuse, North
Bethesda, MD, USA.
(5)Virginia Commonwealth University, Richmond, VA, USA.
(6)Emmes Corporation, Rockville, MD, USA.
(7)Friends Research Institute, 1040 Park Avenue, Suite 103, Baltimore, MD, 21201,
USA.
(8)University of Maryland, College Park, College Park, MD, USA.
Comment in
J Gen Intern Med. 2017 Sep;32(9):1026.
DOI: 10.1007/s11606-017-4079-x
PMCID: PMC5570743
PMID: 28550609 [Indexed for MEDLINE]
1888. Int J Chron Obstruct Pulmon Dis. 2016 Apr 27;11:881-90. doi:
10.2147/COPD.S102280. eCollection 2016.
Müllerová H(1), Landis SH(1), Aisanov Z(2), Davis KJ(3), Ichinose M(4), Mannino
DM(5), Maskell J(1), Menezes AM(6), van der Molen T(7), Oh YM(8), Tabberer M(9),
Han MK(10).
Author information:
(1)GSK, Worldwide Epidemiology, Uxbridge, UK.
(2)Pulmonology Research Institute, Moscow, Russia.
(3)GSK, Worldwide Epidemiology, Upper Providence, PA, USA.
(4)Tohoku University Graduate School of Medicine, Sendai, Japan.
(5)University of Kentucky College of Public Health, Lexington, KY, USA.
(6)Federal University of Pelotas, Pelotas, Brazil.
(7)University of Groningen, University Medical Center Groningen, Groningen, the
Netherlands.
(8)University of Ulsan College of Medicine, Asan Medical Center, Seoul, South
Korea.
(9)GSK, Value Evidence Outcomes, Uxbridge, UK.
(10)Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor,
MI, USA.
Erratum in
Int J Chron Obstruct Pulmon Dis. 2017 Mar 15;12 :859.
BACKGROUND AND AIMS: We used data from the Continuing to Confront COPD
International Patient Survey to test the hypothesis that patients with COPD who
report less engagement with their disease management are also more likely to
report greater impact of the disease.
METHODS: This was a population-based, cross-sectional survey of 4,343 subjects
aged ≥40 years from 12 countries, fulfilling a case definition of COPD based on
self-reported physician diagnosis or symptomatology. The impact of COPD was
measured with COPD Assessment Test, modified Medical Research Council Dyspnea
Scale, and hospital admissions and emergency department visits for COPD in the
prior year. The 13-item Patient Activation Measure (PAM-13) instrument and the
8-item Morisky Medication Adherence Scale (MMAS-8) were used to measure patient
disease engagement and medication adherence, respectively.
RESULTS: Twenty-eight percent of subjects reported being either disengaged or
struggling with their disease (low engagement: PAM-13 levels 1 and 2), and 35%
reported poor adherence (MMAS-8 <6). In univariate analyses, lower PAM-13 and
MMAS-8 scores were significantly associated with poorer COPD-specific health
status, greater breathlessness and lower BMI (PAM-13 only), less satisfaction
with their doctor's management of COPD, and more emergency department visits. In
multivariate regression models, poor satisfaction with their doctor's management
of COPD was significantly associated with both low PAM-13 and MMAS-8 scores; low
PAM-13 scores were additionally independently associated with higher COPD
Assessment Test and modified Medical Research Council scores and low BMI
(underweight).
CONCLUSION: Poor patient engagement and medication adherence are frequent and
associated with worse COPD-specific health status, higher health care
utilization, and lower satisfaction with health care providers. More research
will be needed to better understand what factors can be modified to improve
medication adherence and patient engagement.
DOI: 10.2147/COPD.S102280
PMCID: PMC4853156
PMID: 27217741 [Indexed for MEDLINE]
Moreno G(1), Morales LS, Isiordia M, de Jaimes FN, Tseng CH, Noguera C, Mangione
CM.
Author information:
(1)*UCLA Department of Family Medicine, Los Angeles, CA †School of Medicine
‡School of Public Health, University of Washington, Seattle, WA §Department of
Psychology at the University of California, Davis ∥Golden Valley Health Centers
Inc., Merced ¶UCLA Department of General Internal Medicine, Division of Health
Services, Los Angeles #Community Medical Centers Inc, Stockton **UCLA School of
Public Health, Los Angeles, CA.
DOI: 10.1097/MLR.0000000000000348
PMCID: PMC4398630
PMID: 25811632 [Indexed for MEDLINE]
Campbell NL(1), Skaar TC(2), Perkins AJ(3), Gao S(4), Li L(5), Khan BA(6),
Boustani MA(7).
Author information:
(1)College of Pharmacy, Purdue University, West Lafayette, IN, USA ; Indiana
University Center for Aging Research, Indiana University School of Medicine,
Indianapolis, IN, USA ; Regenstrief Institute, Indiana University School of
Medicine, Indianapolis, IN, USA ; Department of Pharmacy, Eskenazi Health
Services, Indiana University School of Medicine, Indianapolis, IN, USA.
(2)Division of Clinical Pharmacology, Department of Medicine, Indiana University
School of Medicine, Indianapolis, IN, USA.
(3)Indiana University Center for Aging Research, Indiana University School of
Medicine, Indianapolis, IN, USA.
(4)Indiana University Center for Aging Research, Indiana University School of
Medicine, Indianapolis, IN, USA ; Regenstrief Institute, Indiana University
School of Medicine, Indianapolis, IN, USA ; Department of Biostatistics, Indiana
University School of Medicine, Indianapolis, IN, USA.
(5)Department of Medical and Molecular Genetics, Indiana University School of
Medicine, Indianapolis, IN, USA.
(6)Indiana University Center for Aging Research, Indiana University School of
Medicine, Indianapolis, IN, USA ; Regenstrief Institute, Indiana University
School of Medicine, Indianapolis, IN, USA ; Division of Clinical Pharmacology,
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN,
USA.
(7)Indiana University Center for Aging Research, Indiana University School of
Medicine, Indianapolis, IN, USA ; Regenstrief Institute, Indiana University
School of Medicine, Indianapolis, IN, USA ; Center for Innovation and
Implementation Science, Indiana University, Indianapolis, IN, USA.
DOI: 10.2147/CIA.S65980
PMCID: PMC4298284
PMID: 25609939 [Indexed for MEDLINE]
Adherence to pre-exposure prophylaxis among men who have sex with men: A
prospective cohort study.
Qu D(1), Zhong X(2), Xiao G(1), Dai J(3), Liang H(4), Huang A(5).
Author information:
(1)Department of Epidemiology and Health Statistics, School of Public Health and
Management, Chongqing Medical University, Chongqing, China; Research Center for
Medicine and Social Development, Chongqing Medical University, Chongqing, China;
Innovation Center for Social Risk Governance in Health, Chongqing Medical
University, Chongqing, China.
(2)Department of Epidemiology and Health Statistics, School of Public Health and
Management, Chongqing Medical University, Chongqing, China; Research Center for
Medicine and Social Development, Chongqing Medical University, Chongqing, China;
Innovation Center for Social Risk Governance in Health, Chongqing Medical
University, Chongqing, China. Electronic address: 1932352920@qq.com.
(3)Department of Epidemiology and Health Statistics, School of Public Health,
Xinjiang Medical University, Xinjiang, China.
(4)Department of Epidemiology and Health Statistics, School of Public Health,
Guangxi Medical University, Nanning, Guangxi, China.
(5)Key Laboratory of Molecular Biology, Ministry of Molecular Biology, Infectious
Diseases, Chongqing Medical University, Chongqing, China.
Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.ijid.2018.08.006
PMID: 30125688 [Indexed for MEDLINE]
Author information:
(1)1Department of Global Health, School of Health Sciences, Faculty of Medicine,
University of the Ryukyus, Okinawa, 903-0215 Japan.
(2)SATREPS Project for Parasitic Diseases, Vientiane, Lao People's Democratic
Republic.
(3)3Department of Tropical Medicine and Malaria, Research Institute, National
Center for Global Health and Medicine, Tokyo, 162-8655 Japan.
(4)4Institut Pasteur du Laos, Ministry of Health, Vientiane, Lao People's
Democratic Republic.
(5)5Center of Malariology, Parasitology and Entomology, Ministry of Health,
Vientiane, Lao People's Democratic Republic.
(6)6Lao Tropical and Public Health Institute, Ministry of Health, Vientiane, Lao
People's Democratic Republic.
(7)Savannakhet Provincial Health Department, Savannakhet, Lao People's Democratic
Republic.
(8)8Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
DOI: 10.1186/s41182-018-0125-6
PMCID: PMC6303952
PMID: 30607137
Conflict of interest statement: This study was approved by the National Ethics
Committee for Health Research, Ministry of Health, Lao PDR (No. 034/NECHR, 2016)
and the Ethics Review Committee for Epidemiological Study, University of Ryukyus,
Japan (No. 346). Before starting the study, surveyors explained the details of
the study to the participants, such as its purpose, voluntary participation,
information that would be collected and how the data would be stored and managed.
Written informed consent was obtained from each participant. For the healthcare
workers study, self-administered anonymous questionnaires were used.Not
applicable.The authors declare that they have no competing interests.Springer
Nature remains neutral with regard to jurisdictional claims in published maps and
institutional affiliations.
1893. NPJ Prim Care Respir Med. 2017 Dec 8;27(1):64. doi: 10.1038/s41533-017-0064-
4.
Weekly self-measurement of FEV1 and PEF and its impact on ACQ (asthma control
questionnaire)-scores: 12-week observational study with 76 patients.
Werner CU(1), Linde K(2), Schäffner J(2), Storr C(2), Schneider A(2).
Author information:
(1)Technical University of Munich, TUM School of Medicine, Institute of General
Practice, Munich, Germany. christoph.werner@mri.tum.de.
(2)Technical University of Munich, TUM School of Medicine, Institute of General
Practice, Munich, Germany.
DOI: 10.1038/s41533-017-0064-4
PMCID: PMC5722863
PMID: 29222436 [Indexed for MEDLINE]
Author information:
(1)Department of Drugs and Medications, School of Pharmaceutical Sciences of the
UNESP - Univ Estadual Paulista, Araraquara.
(2)Department of Surgery and Anatomy, Americo Brasiliense State Hospital.
(3)Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP), São
Paulo, Brazil.
DOI: 10.2147/PPA.S112108
PMCID: PMC5028166
PMID: 27695297
Daniali SS(1), Eslami AA(2), Maracy MR(3), Shahabi J(4), Mostafavi-Darani F(2).
Author information:
(1)PhD Candidate, Student Research Committee, Department of Health Education and
Health Promotion, School of Health, Isfahan University of Medical Sciences,
Isfahan, Iran.
(2)Associate Professor, Department of Health Education and Promotion, School of
Health, Isfahan University of Medical Sciences, Isfahan, Iran.
(3)Professor, Department of Epidemiology and Biostatistics, School of Public
Health, Isfahan University of Medical Sciences, Isfahan, Iran.
(4)Assistant Professor, Heart Failure Research Center, Cardiovascular Research
Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
PMCID: PMC5515187
PMID: 28761451
Perez L(1), Morales KH(2), Klusaritz H(3), Han X(2), Huang J(1), Rogers M(4),
Bennett IM(5), Rand CS(6), Ndicu G(1), Apter AJ(7).
Author information:
(1)Division of Pulmonary Allergy Critical Care Medicine, University of
Pennsylvania, Philadelphia, Pa; Perelman School of Medicine, University of
Pennsylvania, Philadelphia, Pa.
(2)Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa;
Department of Biostatistics and Epidemiology, University of Pennsylvania,
Philadelphia, Pa.
(3)Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa;
Department of Family Medicine and Community Health, University of Pennsylvania,
Philadelphia, Pa.
(4)Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa;
Division of General Internal Medicine, University of Pennsylvania, Philadelphia,
Pa.
(5)Departments of Family Medicine & Psychiatry and Behavioral Sciences,
University of Washington, Seattle, Wash.
(6)Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of
Medicine, Baltimore, Md.
(7)Division of Pulmonary Allergy Critical Care Medicine, University of
Pennsylvania, Philadelphia, Pa; Perelman School of Medicine, University of
Pennsylvania, Philadelphia, Pa. Electronic address: apter@mail.med.upenn.edu.
DOI: 10.1016/j.jaci.2016.08.043
PMCID: PMC5148700
PMID: 27744030 [Indexed for MEDLINE]
McCusker J(1)(2), Cole M(3)(4), Lambert S(2)(5), Yaffe M(6)(7), Ciampi A(1)(2),
Belzile E(2).
Author information:
(1)1 Department of Epidemiology, Biostatistics and Occupational Health, McGill
University, Montreal, Quebec.
(2)2 St. Mary's Research Centre, Montreal, Quebec.
(3)3 Department of Psychiatry, McGill University, Montreal, Quebec.
(4)4 Geriatric Psychiatry Division, St. Mary's Hospital Center, Montreal, Quebec.
(5)5 Ingram School of Nursing, McGill University, Montreal, Quebec.
(6)6 Department of Family Medicine, McGill University, Montreal, Quebec.
(7)7 Family Medicine Centre, St. Mary's Hospital Center, Montreal, Quebec.
DOI: 10.1177/0706743716648299
PMCID: PMC5302106
PMID: 27310241 [Indexed for MEDLINE]
Snyder ME(1), Jaynes HA(1), Gernant SA(2), Lantaff WM(1), Hudmon KS(1), Doucette
WR(3).
Author information:
(1)1 Purdue University College of Pharmacy, Indianapolis, Indiana.
(2)2 Nova Southeastern University School of Pharmacy, Davie, Florida.
(3)3 University of Iowa College of Pharmacy, Iowa City.
BACKGROUND: Medication therapy management (MTM) program evaluations have revealed
mixed outcomes, with some studies finding favorable outcomes and others finding
no differences between patients who received MTM versus those who did not. One
possible reason for outcomes variability is differences in delivery of MTM
programs. The Chronic Care Model (CCM) provides a framework for how health care
organizations can improve care for the chronically ill through 6 elements:
organization of health care, delivery system design, clinical information
systems, decision support, self-management, and linkages to community resources.
OBJECTIVE: To apply the CCM to understand variation in MTM delivery and formulate
policy recommendations.
METHODS: This study used a mixed-methods descriptive analysis of MTM delivery.
Investigators conducted visits to a purposeful sample of MTM practices to observe
MTM and interview participants. The pharmacists and staff of these practices
completed a modified Assessment of Chronic Illness Care (ACIC). Pairs of
investigators analyzed interview transcripts to identify themes. Demographics and
ACIC scores were summarized using descriptive statistics. After analysis,
investigators discussed overarching themes and policy implications organized by
CCM elements.
RESULTS: Seven practices participated, and 87 participants were interviewed.
Based on ACIC scores, MTM patient volume, and payer mix, practices were
categorized as Early Maturity Level or Later Maturity Level. From the model,
organization of health care themes included whether MTM was the practice's core
competence, belief/confidence in the MTM process, lack of formal rewards, and the
influence of organizational goals and external environment. Delivery system
design themes pertained to the extent that MTM processes were formalized.
Clinical information systems themes were the extent to which systems were
influenced by payers, efficiency strategies, and the accuracy and availability of
information. In considering clinical decision support themes, alert design
limitations and variation in user approaches to alerts based on experience were
noted. We observed strong support for patient self-management; when present,
barriers were attributed to the patient, MTM provider, or payer. Referral to
community resources was minimal. Numerous policy implications were identified.
CONCLUSIONS: Our research identified numerous ways by which MTM delivery varies,
particularly by MTM practice maturity level. These findings provide evidence for
several policy changes that could be considered to optimize MTM delivery,
encourage alignment with the CCM, and promote practice maturation.
DISCLOSURES: This research and a portion of Snyder's salary were supported by
grant number K08HS022119 from the Agency for Healthcare Research and Quality. The
content is solely the responsibility of the authors and does not necessarily
represent the official views of the Agency for Healthcare Research and Quality.
Snyder reports consulting fees from Westat for an evaluation of the CMS Enhanced
MTM program. The other authors have nothing to disclose. Portions of this
research have been presented as abstracts at the following conferences: (a) 2017
Academy Health Annual Research Meeting; June 25-27, 2017; New Orleans, LA; (b)
2015 American Society of Health-System Pharmacists Clinical Midyear Meeting;
December 4-8, 2015; New Orleans, LA; and
(c) 2014 North American Primary Care Research Group (NAPCRG) Annual Meeting;
November 21-25, 2014; New York, NY.
DOI: 10.18553/jmcp.2018.24.9.896
PMID: 30156453 [Indexed for MEDLINE]
Author information:
(1)Johns Hopkins University School of Medicine, Department of Psychiatry and
Behavioral Sciences, Baltimore, MD, USA. Electronic address: ahuhn1@jhu.edu.
(2)Johns Hopkins University School of Medicine, Department of Psychiatry and
Behavioral Sciences, Baltimore, MD, USA.
DOI: 10.1016/j.drugalcdep.2017.08.019
PMCID: PMC5648596
PMID: 28942031 [Indexed for MEDLINE]
Carpenter DM(1), Tudor GE(2), Sayner R(3), Muir KW(4), Robin AL(5), Blalock
SJ(6), Hartnett ME(7), Giangiacomo AL(8), Sleath BL(6).
Author information:
(1)Eshelman School of Pharmacy, University of North Carolina at Chapel Hill,
Asheville, USA. Electronic address: dmcarpenter@unc.edu.
(2)Department of Mathematics and Statistics, Husson University, Bangor, USA.
(3)School of Medicine, Stanford University, Stanford, CA, USA.
(4)School of Medicine, Duke University, & Durham VA Medical Center, Durham, USA.
(5)Wilmer Institute and Bloomberg School of Public Health; Johns Hopkins
University, & University of Maryland, Baltimore, MD, USA.
(6)Eshelman School of Pharmacy, University of North Carolina at Chapel Hill,
Chapel Hill, USA.
(7)John A. Moran Eye Center, University of Utah, Salt Lake City, USA.
(8)School of Medicine, Emory University, Atlanta, USA.
DOI: 10.1016/j.pec.2015.07.001
PMCID: PMC4703566
PMID: 26223851
Author information:
(1)College of Nursing, Seoul National University, Seoul, Republic of Korea.
BACKGROUND: Mobile phones have been actively used in various ways for diabetes
self-care. Mobile phone apps can manage lifestyle factors such as diet, exercise,
and medication without time or place restrictions. A systematic review has found
these apps to be effective in reducing blood glucose. However, the existing apps
were developed and evaluated without a theoretical framework to explain the
process of changes in diabetes self-care behaviors.
OBJECTIVE: This study aimed to evaluate the diabetes self-care app that we
developed by measuring differences in diabetes self-care factors between before
and after using the app with the Information-Motivation-Behavioral skills model
of Diabetes Self-Care (IMB-DSC).
METHODS: We conducted a single-group pre- and postintervention study with a
convenience sample of diabetes patients. A total of 38 adult patients with
diabetes who had an Android smartphone were recruited. After conducting a
preliminary survey of those who agreed to participate in the study, we provided
them with a manual and a tutorial video about the diabetes self-care app. The app
has functions for education, recommendations, writing a diary, recording, goal
setting, sharing, communication, feedback, and interfacing with a glucometer, and
it was applied for 4 weeks. We measured the general characteristics of
participants, their history of diabetes self-care app usage, IMB-DSC factors, and
blood glucose levels. The IMB-DSC factors of information, personal motivation,
social motivation, behavioral skills, and behaviors were measured using an
assessment tool consisting of 87 items extracted from the Diabetes Knowledge
Test, third version of the Diabetes Attitude Scale, Diabetes Family Behavior
Checklist, and Diabetes Self-Management Assessment Report Tool.
RESULTS: The mean age of the participants was 43.87 years. A total 30
participants out of 38 (79%) had type 2 diabetes and 8 participants (21%) had
type 1 diabetes. The most frequently used app function was recording, which was
used by 34 participants out of 38 (89%). Diabetes self-care behaviors (P=.02) and
diabetes self-care social motivation (P=.05) differed significantly between pre-
and postintervention, but there was no significant difference in diabetes
self-care information (P=.85), diabetes self-care personal motivation (P=.57), or
diabetes self-care behavioral skills (P=.89) between before and after using the
diabetes self-care app.
CONCLUSIONS: Diabetes self-care social motivation was significantly improved with
our diabetes self-care app by sharing experiences and sympathizing with other
diabetes patients. Diabetes self-care behavior was also significantly improved
with the diabetes self-care app by providing an interface with a glucometer that
removes the effort of manual input. Diabetes self-care information, diabetes
self-care personal motivation, and diabetes self-care behavioral skills were not
significantly improved. However, they will be improved with additional offline
interventions such as reflective listening and simulation.
DOI: 10.2196/11590
PMCID: PMC6495295
PMID: 30998218
1902. Health Educ Res. 2015 Oct;30(5):693-705. doi: 10.1093/her/cyv034. Epub 2015
Sep
2.
Sleath B(1), Carpenter DM(2), Blalock SJ(2), Sayner R(2), Muir KW(3), Slota C(2),
Giangiacomo AL(4), Hartnett ME(5), Tudor G(6), Robin AL(7).
Author information:
(1)UNC Eshelman School of Pharmacy & Cecil G. Sheps Center for Health Services
Research, betsy_sleath@unc.edu.
(2)Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of
Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
(3)Department of Ophthalmology, School of Medicine, Duke University, Durham VA
Medical Center, Health Services Research and Development, Durham, NC, USA.
(4)Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA
30322, USA.
(5)Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center,
University of Utah, Salt Lake City, UT 84132, USA.
(6)Department of Science and Mathematics, Director of Institutional Research,
Husson University, Bangor, ME 04401, USA.
(7)Department of Ophthalmology, University of Maryland, Baltimore, MD, USA,
Department of Ophthalmology, University of Michigan, Ann Arbor, MI, USA,
Department of International Health, Bloomberg School of Public Health, Johns
Hopkins University, Baltimore, MD, USA, Department of Ophthalmology, Johns
Hopkins School of Medicine, Baltimore, MD 21215, USA.
© The Author 2015. Published by Oxford University Press. All rights reserved. For
permissions, please email: journals.permissions@oup.com.
DOI: 10.1093/her/cyv034
PMCID: PMC4668753
PMID: 26338986 [Indexed for MEDLINE]
1903. Health Promot Chronic Dis Prev Can. 2017 May;37(5):160-171. doi:
10.24095/hpcdp.37.5.04.
Use of medication and psychological counselling among Canadians with mood and/or
anxiety disorders.
O'Donnell S(1), Syoufi M(1), Jones W(2), Bennett K(3), Pelletier L(1).
Author information:
(1)Public Health Agency of Canada, Ottawa, Ontario, Canada.
(2)Centre for Applied Research in Mental Health and Addiction, Simon Fraser
University, Burnaby, British Columbia, Canada.
(3)Department of Health Research Methods, Evidence, and Impact (formerly
Department of Clinical Epidemiology and Biostatistics), McMaster University,
Hamilton, Ontario, Canada.
1904. BMC Health Serv Res. 2016 Jul 28;16:314. doi: 10.1186/s12913-016-1573-5.
Bozzani FM(1)(2), Arnold M(3)(4), Colbourn T(5), Lufesi N(6), Nambiar B(5)(7),
Masache G(7), Skordis-Worrall J(5).
Author information:
(1)Department of Global Health and Development, London School of Hygiene &
Tropical Medicine, 15-17 Tavistock Place, London, WC1H 9SH, UK.
fiammetta.bozzani@lshtm.ac.uk.
(2)Institute for Global Health, University College London, London, UK.
fiammetta.bozzani@lshtm.ac.uk.
(3)Munich Center of Health Sciences, Ludwig-Maximilians-Universität München,
Munich, Germany.
(4)Institute of Health Economics and Health Care Management, Helmholtz Zentrum
München, Neuherberg, Germany.
(5)Institute for Global Health, University College London, London, UK.
(6)ARI Programme, Ministry of Health, Lilongwe, Malawi.
(7)Parent And Child Health Initiative (PACHI), Lilongwe, Malawi.
BACKGROUND: Human resources are a major cost driver in childhood pneumonia case
management. Introduction of 13-valent pneumococcal conjugate vaccine (PCV-13) in
Malawi can lead to savings on staff time and salaries due to reductions in
pneumonia cases requiring admission. Reliable estimates of human resource costs
are vital for use in economic evaluations of PCV-13 introduction.
METHODS: Twenty-eight severe and twenty-four very severe pneumonia inpatients
under the age of five were tracked from admission to discharge by paediatric ward
staff using self-administered timesheets at Mchinji District Hospital between
June and August 2012. All activities performed and the time spent on each
activity were recorded. A monetary value was assigned to the time by allocating a
corresponding percentage of the health workers' salary. All costs are reported in
2012 US$.
RESULTS: A total of 1,017 entries, grouped according to 22 different activity
labels, were recorded during the observation period. On average, 99 min (standard
deviation, SD = 46) were spent on each admission: 93 (SD = 38) for severe and 106
(SD = 55) for very severe cases. Approximately 40 % of activities involved
monitoring and stabilization, including administering non-drug therapies such as
oxygen. A further 35 % of the time was spent on injecting antibiotics. Nurses
provided 60 % of the total time spent on pneumonia admissions, clinicians 25 %
and support staff 15 %. Human resource costs were approximately US$ 2 per bed-day
and, on average, US$ 29.5 per severe pneumonia admission and US$ 37.7 per very
severe admission.
CONCLUSIONS: Self-reporting was successfully used in this context to generate
reliable estimates of human resource time and costs of childhood pneumonia
treatment. Assuming vaccine efficacy of 41 % and 90 % coverage, PCV-13
introduction in Malawi can save over US$ 2 million per year in staff costs alone.
DOI: 10.1186/s12913-016-1573-5
PMCID: PMC4964305
PMID: 27464679 [Indexed for MEDLINE]
Author information:
(1)College of Medicine, Medical University of South Carolina, Charleston, SC
29425, USA. davidst@musc.edu.
(2)College of Nursing, Medical University of South Carolina, Charleston, SC
29425, USA. davidst@musc.edu.
(3)College of Medicine, Medical University of South Carolina, Charleston, SC
29425, USA. mcgillij@musc.edu.
(4)College of Nursing, Medical University of South Carolina, Charleston, SC
29425, USA. muellerm@musc.edu.
(5)College of Nursing, Medical University of South Carolina, Charleston, SC
29425, USA.
(6)College of Nursing, Medical University of South Carolina, Charleston, SC
29425, USA. favela@musc.edu.
(7)College of Nursing, Medical University of South Carolina, Charleston, SC
29425, USA. anderan@musc.edu.
(8)College of Nursing, Medical University of South Carolina, Charleston, SC
29425, USA. torresma@musc.edu.
(9)College of Nursing, Medical University of South Carolina, Charleston, SC
29425, USA. ruggierk@musc.edu.
(10)College of Medicine, Medical University of South Carolina, Charleston, SC
29425, USA. treiberf@musc.edu.
(11)College of Nursing, Medical University of South Carolina, Charleston, SC
29425, USA. treiberf@musc.edu.
DOI: 10.3390/jpm5040389
PMCID: PMC4695862
PMID: 26593951
Author information:
(1)MRCG Keneba at MRC Unit The Gambia, and MRC International Nutrition Group,
London School of Hygiene and Tropical Medicine, London, UK.
Emily.Teshome@lshtm.ac.uk.
(2)Faculty of Epidemiology and Population Heath, London School of Hygiene and
Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
Emily.Teshome@lshtm.ac.uk.
(3)Maseno University, School of Public Health and Community Development, Maseno,
Kenya.
(4)MRCG Keneba at MRC Unit The Gambia, and MRC International Nutrition Group,
London School of Hygiene and Tropical Medicine, London, UK.
(5)Faculty of Epidemiology and Population Heath, London School of Hygiene and
Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
(6)Cell Biology and Immunology Group and Division of Human Nutrition, Wageningen
University, Maseno, The Netherlands.
DOI: 10.1186/s12889-018-5097-2
PMCID: PMC5796300
PMID: 29391008 [Indexed for MEDLINE]
Haley WE(1), Gilbert ON(2), Riley RF(3), Newman JC(4), Roumie CL(5), Whittle
J(6), Kronish IM(7), Tamariz L(8), Wiggers A(9), Morisky DE(10), Conroy MB(11),
Kovalik E(12), Kressin NR(13), Muntner P(14), Goff DC Jr(15); SPRINT Study
Research Group.
Author information:
(1)Mayo Clinic, Jacksonville, FL, USA. Electronic address:
haley.william@mayo.edu.
(2)Section on Cardiovascular Medicine, Wake Forest University Health Sciences,
Winston-Salem, NC, USA.
(3)Division of Cardiology, University of Washington, Seattle, WA, USA.
(4)Medical University of South Carolina, Charleston, SC, USA.
(5)VA Tennessee Valley Healthcare System Geriatric Research and Education
Clinical Center Nashville and Vanderbilt University Medical Center, Nashville,
TN, USA.
(6)Milwaukee VA Medical Center, Milwaukee, WI, USA.
(7)Columbia University Medical Center, New York, NY, USA.
(8)Miami Veterans Affairs and University of Miami Health System, Miami, FL, USA.
(9)University Hospitals, Cleveland, OH, USA.
(10)UCLA School of Public Health, Los Angeles, CA, USA.
(11)Department of Medicine, University of Pittsburgh School of Medicine,
Pittsburgh, PA, USA.
(12)Duke University Medical Center, Durham, NC, USA.
(13)Department of Veterans Affairs, Boston University School of Medicine, Boston,
MA, USA.
(14)University of Alabama School of Public Health, Birmingham, AL, USA.
(15)Colorado School of Public Health, Denver, CO, USA.
We examined baseline data from the Systolic Blood Pressure Intervention Trial
(SPRINT) to investigate whether medication adherence, measured by the 8-item
Morisky Medication Adherence Scale (MMAS-8), was associated with systolic blood
pressure (SBP) and whether MMAS-8 score and number of antihypertensive
medications interacted in influencing SBP. A total of 8435 SPRINT participants
were included: 21.2% had low adherence (MMAS-8: <6); 40.0% had medium adherence
(6 to <8); and 38.8% had high adherence (8). SBP was <140 mm Hg in 54.6%;
140-160 mm Hg in 36.6%; and >160 mm Hg in 8.8%. In multivariable regression,
medium vs. low adherence weakly associated with lower SBP (odds ratio: 1.17;
confidence interval: 1.04, 1.31). SPRINT eligibility criteria should be
considered when interpreting results. Efforts to understand and enhance adherence
are crucial to improve population health, and using self-report instruments might
be considered for predicting treatment adherence and response in future efficacy
trials and for identifying patients for adherence support in clinical practice.
Author information:
(1)Department of Rehabilitation, Aged and Extended Care, Faculty of Medicine,
Nursing and Health Sciences, School of Health Sciences, Flinders University,
Level 4, Rehabilitation Building, Flinders Medical Centre, Flinders Drive,
Bedford park, SA, 5042, Australia. Stephanie.harrison@flinders.edu.au.
(2)NHMRC Cognitive Decline Partnership Centre, University of Sydney, Sydney, NSW,
Australia. Stephanie.harrison@flinders.edu.au.
(3)NHMRC Cognitive Decline Partnership Centre, University of Sydney, Sydney, NSW,
Australia.
(4)Kolling Institute of Medical Research, University of Sydney and Royal North
Shore Hospital, St Leonards, NSW, 2065, Australia.
(5)Department of Rehabilitation, Aged and Extended Care, Faculty of Medicine,
Nursing and Health Sciences, School of Health Sciences, Flinders University,
Level 4, Rehabilitation Building, Flinders Medical Centre, Flinders Drive,
Bedford park, SA, 5042, Australia.
(6)Institute for Choice, University of South Australia, GPO Box 2471, Adelaide,
SA, 5001, Australia.
(7)Infection & Immunity - Aboriginal Health, SAHMRI, PO Box 11060, Adelaide, SA,
5001, Australia.
(8)Mary MacKillop Institute for Health Research, Australian Catholic University,
215 Spring Street, Melbourne, VIC, 3000, Australia.
BACKGROUND: The potential harms of some medications may outweigh their potential
benefits (inappropriate medication use). Despite recommendations to avoid the use
of potentially inappropriate medications (PIMs) in older adults, the prevalence
of PIM use is high in different settings including residential aged care.
However, it remains unclear what the costs of these medications are in this
setting. The main objective of this study was to determine the costs of PIMs in
older adults living in residential care. A secondary objective was to examine if
there was a difference in costs of PIMs in a home-like model of residential care
compared to an Australian standard model of care.
METHODS: Participants included 541 participants from the Investigation Services
Provided in the Residential Environment for Dementia (INSPIRED) Study. The
INSPIRED study is a cross-sectional study of 17 residential aged care facilities
in Australia. 12 month medication costs were determined for the participants and
PIMs were identified using the 2015 updated Beers Criteria for older adults.
RESULTS: Of all of the medications dispensed in 1 year, 15.9% were PIMs and 81.4%
of the participants had been exposed to a PIM. Log-linear models showed exposure
to a PIM was associated with higher total medication costs (Adjusted β = 0.307,
95% CI 0.235 to 0.379, p < 0.001). The mean proportion (±SD) of medication costs
that were spent on PIMs in 1 year was 17.5% (±17.8) (AUD$410.89 ± 479.45 per
participant exposed to a PIM). The largest PIM costs arose from proton-pump
inhibitors (34.4%), antipsychotics (21.0%) and benzodiazepines (18.7%). The odds
of incurring costs from PIMs were 52% lower for those residing in a home-like
model of care compared to a standard model of care.
CONCLUSIONS: The use of PIMs for older adults in residential care facilities is
high and these medications represent a substantial cost which has the potential
to be lowered. Further research should investigate whether medication reviews in
this population could lead to potential cost savings and improvement in clinical
outcomes. Adopting a home-like model of residential care may be associated with
reduced prevalence and costs of PIMs.
DOI: 10.1186/s12877-018-0704-8
PMCID: PMC5765623
PMID: 29325531 [Indexed for MEDLINE]
Measures That Identify Prescription Medication Misuse, Abuse, and Related Events
in Clinical Trials: ACTTION Critique and Recommended Considerations.
Smith SM(1), Jones JK(2), Katz NP(3), Roland CL(4), Setnik B(5), Trudeau JJ(6),
Wright S(7), Burke LB(8), Comer SD(9), Dart RC(10), Dionne R(11), Haddox JD(12),
Jaffe JH(13), Kopecky EA(14), Martell BA(15), Montoya ID(16), Stanton M(17),
Wasan AD(18), Turk DC(19), Dworkin RH(20).
Author information:
(1)Department of Anesthesiology, University of Rochester School of Medicine and
Dentistry, Rochester, New York. Electronic address:
shannon1_smith@urmc.rochester.edu.
(2)The Degge Group, Fairfax, Virginia; Departments of Pharmacology and Health
Sciences, Georgetown University School of Medicine, Washington, DC; School of
Public Health, University of Michigan School of Public Health, Ann Arbor,
Michigan.
(3)Analgesic Solutions, Natick, Massachusetts; Departments of Anesthesiology and
Public Health and Community Medicine, Tufts University, Boston, Massachusetts.
(4)Pfizer Inc, Cary, North Carolina.
(5)INC Research, Raleigh, North Carolina.
(6)Boehringer Ingelheim, Ridgefield, Connecticut.
(7)GW Pharmaceuticals, plc, London, United Kingdom.
(8)LORA Group, LLC, Royal Oak, and School of Pharmacy, University of Maryland,
Baltimore, Maryland.
(9)Department of Psychiatry, Columbia University, New York State Psychiatric
Institute, New York, New York.
(10)Division of Clinical Pharmacology and Toxicology, University of Colorado
School of Medicine and Rocky Mountain Poison & Drug Center, Denver Health,
Denver, Colorado.
(11)Department of Pharmacology and Toxicology, Brody School of Medicine, East
Carolina University, Greenville, North Carolina.
(12)Departments of Anesthesiology and Public Health and Community Medicine, Tufts
University, Boston, Massachusetts; Purdue Pharma LP, Stamford, Connecticut.
(13)Department of Psychiatry, University of Maryland School of Medicine,
Baltimore, Maryland.
(14)Collegium Pharmaceutical, Inc, Canton, Massachusetts.
(15)BAM Consultants, Guilford, Connecticut; Department of Internal Medicine, Yale
University School of Medicine, New Haven, Connecticut.
(16)National Institute on Drug Abuse, Bethesda, Maryland.
(17)Horizon Pharma, Inc, Deerfield, Illinois.
(18)Departments of Anesthesiology and Psychiatry, University of Pittsburgh School
of Medicine, Pittsburgh, Pennsylvania.
(19)Department of Anesthesiology and Pain Medicine, University of Washington,
Seattle, Washington.
(20)Department of Anesthesiology, Neurology, and Center for Human Experimental
Therapeutics, University of Rochester School of Medicine and Dentistry,
Rochester, New York.
Copyright © 2017 American Pain Society. Published by Elsevier Inc. All rights
reserved.
DOI: 10.1016/j.jpain.2017.03.015
PMCID: PMC5660635
PMID: 28479207 [Indexed for MEDLINE]
Adherence to Newly Prescribed Diabetes Medications Among Insured Latino and White
Patients With Diabetes.
Fernández A(1), Quan J(1), Moffet H(2), Parker MM(2), Schillinger D(1), Karter
AJ(2).
Author information:
(1)Division of General Internal Medicine, San Francisco General Hospital, San
Francisco, California2Department of Medicine, University of California-San
Francisco, San Francisco3Center for Vulnerable Populations, San Francisco General
Hospital, San Francisco, California.
(2)Division of Research, Kaiser Permanente, Oakland, California.
DOI: 10.1001/jamainternmed.2016.8653
PMCID: PMC5814298
PMID: 28114642 [Indexed for MEDLINE]
Louis ED(1).
Author information:
(1)GH Sergievsky Center, College of Physicians and Surgeons, Columbia University,
New York, NY, USA; Department of Neurology, College of Physicians and Surgeons,
Columbia University, New York, NY, USA; Department of Epidemiology, Mailman
School of Public Health, Columbia University, New York, NY, USA; Taub Institute
for Research on Alzheimer's Disease and the Aging Brain, College of Physicians
and Surgeons, Columbia University, New York, NY, USA. Electronic address:
EDL2@columbia.edu.
DOI: 10.1016/j.parkreldis.2014.12.001
PMCID: PMC4306620
PMID: 25523964 [Indexed for MEDLINE]
McDonald LM(1), Griffin HJ(1), Angeli A(1), Torkamani M(1), Georgiev D(1),
Jahanshahi M(1).
Author information:
(1)Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute
of Neurology, London, United Kingdom.
DOI: 10.1371/journal.pone.0135149
PMCID: PMC4540447
PMID: 26284366 [Indexed for MEDLINE]
Author information:
(1)Center for Health Equity Research, Brown University, 121 South Main Street,
Providence, RI, 02903, USA. matthew_mimiaga@brown.edu.
(2)Departments of Behavioral & Social Health Sciences and Epidemiology, Brown
University School of Public Health, Providence, RI, USA.
matthew_mimiaga@brown.edu.
(3)Department of Psychiatry and Human Behavior, Brown University Alpert Medical
School, Providence, RI, USA. matthew_mimiaga@brown.edu.
(4)The Fenway Institute, Fenway Health, Boston, MA, USA.
matthew_mimiaga@brown.edu.
(5)Division of Adolescent Medicine, Ann & Robert H. Lurie Children's Hospital of
Chicago, Chicago, IL, USA.
(6)Feinberg School of Medicine, Department of Pediatrics, Northwestern
University, Chicago, IL, USA.
(7)Center for Health Equity Research, Brown University, 121 South Main Street,
Providence, RI, 02903, USA.
(8)Departments of Behavioral & Social Health Sciences and Epidemiology, Brown
University School of Public Health, Providence, RI, USA.
(9)The Fenway Institute, Fenway Health, Boston, MA, USA.
BACKGROUND: HIV infection among youth in the United States is on the rise. A high
level of antiretroviral therapy (ART) adherence is crucial to treatment success
and can minimize the population burden of the disease. However, the overall rate
of ART adherence among youth is generally suboptimal and no published efficacious
interventions exist to address the specific needs of this population. This paper
describes the design of a stepped-care, "adaptive" ART adherence intervention
protocol for HIV-infected adolescents and young adults.
METHODS: This is a randomized controlled trial (RCT) to establish the efficacy of
"Positive STEPS," a behavioral and technology-based intervention to optimize ART
adherence and viral suppression among HIV-infected youth, ages 16 to 29.
Participants are equally randomized to 1) the Positive STEPS intervention, which
begins with two-way daily text messaging as a reminder system to take their
medications; participants progress to a more intensive in-person counseling
intervention if text messaging is not sufficient to overcome barriers; or 2) or
standard of care (SOC). At randomization, all participants receive standardized
ART adherence education. During the 4 major study assessment visits (baseline,
4-, 8-, and 12-months), participants have their blood drawn to measure HIV viral
load and complete a mix of computer-based self-administered and
interviewer-administered behavioral and psychosocial measures. The primary
outcomes are improvements in viral load and ART adherence measured via a
medication-tracking device (i.e., Wisepill) and self-report.
DISCUSSION: Behavioral interventions are greatly needed to improve ART adherence
among HIV-infected adolescents and young adults and prevent onward transmission.
If effective, the intervention tested here will be one of the first
rigorously-designed efficacy trials to promote ART adherence in this population,
using an approach that holds promise for being readily integrated into real-world
clinical settings.
TRIAL REGISTRATION: ClinicalTrials.gov number NCT03092531 , registered March 28,
2017.
DOI: 10.1186/s12889-018-5815-9
PMCID: PMC6043988
PMID: 30001703 [Indexed for MEDLINE]
1914. Ann Fam Med. 2015 Aug;13 Suppl 1:S36-41. doi: 10.1370/afm.1756.
Are Low-Income Peer Health Coaches Able to Master and Utilize Evidence-Based
Health Coaching?
Goldman ML(1), Ghorob A(1), Hessler D(1), Yamamoto R(1), Thom DH(1), Bodenheimer
T(2).
Author information:
(1)Center for Excellence in Primary Care, Department of Family and Community
Medicine, University of California, San Francisco, San Francisco, California.
(2)Center for Excellence in Primary Care, Department of Family and Community
Medicine, University of California, San Francisco, San Francisco, California
TBodenheimer@fcm.ucsf.edu.
PURPOSE: A randomized controlled trial found that patients with diabetes had
lower HbA1c levels after 6 months of peer health coaching than patients who did
not receive coaching. This paper explores whether the peer coaches in that trial,
all low-income patients with diabetes, mastered and utilized an evidence-based
health coaching training curriculum. The curriculum included 5 core features:
ask-tell-ask, closing the loop, know your numbers, behavior-change action plans,
and medication adherence counseling.
METHODS: This paper includes the results of exams administered to trainees, exit
surveys performed with peer coaches who completed the study and those who dropped
out, observations of peer coaches meeting with patients, and analysis of in-depth
interviews with peer coaches who completed the study.
RESULTS: Of the 32 peer coach trainees who completed the training, 71.9% lacked a
college degree; 25.0% did not graduate from high school. The 26 trainees who
passed the exams attended 92.7% of training sessions compared with 80.6% for the
6 trainees who did not pass. Peer coaches who completed the study wanted to
continue peer coaching work and had confidence in their abilities despite their
not consistently employing the coaching techniques with their patients.
Quotations describe coaches' perceptions of the training.
CONCLUSIONS: Of low-income patients with diabetes who completed the
evidenced-based health coaching training, 81% passed written and oral exams and
became effective peer health coaches, although they did not consistently use the
techniques taught.
DOI: 10.1370/afm.1756
PMCID: PMC4648140
PMID: 26304970 [Indexed for MEDLINE]
1915. BMC Health Serv Res. 2017 Mar 14;17(1):206. doi: 10.1186/s12913-017-2103-9.
Examining the relationship between therapeutic self-care and adverse events for
home care clients in Ontario, Canada: a retrospective cohort study.
Author information:
(1)Faculty of Health Sciences, University of Ontario Institute of Technology,
2000 Simcoe St N, Oshawa, ON, L1H 7K4, Canada. winnie.sun@mail.utoronto.ca.
(2)Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, 155 College
Street, Suite 130, Toronto, ON, M5T 1P8, Canada. winnie.sun@mail.utoronto.ca.
(3)Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, 155 College
Street, Suite 130, Toronto, ON, M5T 1P8, Canada.
(4)Institute of Health Policy Management and Evaluation, University Toronto, 155
College Street, 4th floor, Toronto, ON, M5T 3M6, Canada.
DOI: 10.1186/s12913-017-2103-9
PMCID: PMC5351056
PMID: 28292301 [Indexed for MEDLINE]
Author information:
(1)Department of Biostatistics and Epidemiologyok, University of Pennsylvania,
Philadelphia, PA, 19104, USA. bhimes@upenn.edu.
(2)Computational Health Informatics Program, Boston Children's Hospital, Boston,
MA, 02115, USA.
(3)Division of Adolescent Medicine, Boston Children's Hospital, Boston, MA,
02115, USA.
Asthma and chronic obstructive pulmonary disease (COPD) are common chronic
obstructive lung disorders in the US that affect over 49 million people. There is
no cure for asthma or COPD, but clinical guidelines exist for controlling
symptoms that are successful in most patients that adhere to their treatment
plan. Health information technologies (HITs) are revolutionizing healthcare by
becoming mainstream tools to assist patients in self-monitoring and
decision-making, and subsequently, driving a shift toward a care model
increasingly centered on personal adoption and use of digital and web-based
tools. While the number of chronic pulmonary disease HITs is rapidly increasing,
most have not been validated as clinically effective tools for the management of
disease. Online communities for asthma and COPD patients are becoming sources of
empowerment and support, as well as facilitators of patient-centered research
efforts. In addition to empowering patients and facilitating disease
self-management, HITs offer promise to aid researchers in identifying chronic
pulmonary disease endotypes and personalized treatments based on patient-specific
profiles that integrate symptom occurrence and medication usage with
environmental and genomic data.
DOI: 10.1186/s12931-016-0354-3
PMCID: PMC4822326
PMID: 27048618 [Indexed for MEDLINE]
1917. BMC Health Serv Res. 2015 Sep 26;15:419. doi: 10.1186/s12913-015-1089-4.
BACKGROUND: The aim of this study was to evaluate the prevalence of self-reported
underuse of medications due to procurement costs amongst older persons from seven
European urban communities.
METHODS: The data were collected in a cross-sectional study ("ABUEL, Elder abuse:
A multinational prevalence survey") in 2009. Randomly selected people aged 60-84
years (n = 4,467) from seven urban communities: Stuttgart (Germany), Athens
(Greece), Ancona (Italy), Kaunas (Lithuania), Porto (Portugal), Granada (Spain)
and Stockholm (Sweden) were interviewed. Response rate - 45.2%. Ethical
permission was received in each country.
RESULTS: The results indicate that 3.6% (n = 162) of the respondents
self-reported refraining from buying prescribed medications due to cost. The
highest prevalence of this problem was identified in Lithuania (15.7%, n = 99)
and Portugal (4.3%, n = 28). Other countries reported lower percentages of
refraining from buying medications (Germany - 2.0%, Italy - 1.6%, Sweden - 1.0%,
Greece - 0.6%, Spain - 0.3%). Females refrained more often from buying
medications than males (2.6% vs. 4.4%, p < 0.0001). The prevalence of this
refraining tended to increase with economic hardship.
DISCUSSION: These differences between countries can be only partly described by
the financing of health-care systems. In spite of the presence of cost
reimbursement mechanisms, patients need to make co-payments (or in some cases to
pay the full price) for prescribed medications. This indicates that the
purchasing power of people in 10.1186/s12913-015-1089-4 the particular country
can play a major role and be related with the economic situation in the country.
Lithuania, which has reported the highest refrain rates, had the lowest gross
domestic product (at the time of conducting this study) of all participating
countries in the study.
CONCLUSIONS: Refraining from buying the prescribed medications due to cost is a
problem for women and men in respect to ageing people in Europe. Prevalence
varies by country, sex, and economic hardship.
DOI: 10.1186/s12913-015-1089-4
PMCID: PMC4583739
PMID: 26410226 [Indexed for MEDLINE]
Author information:
(1)Department of Pharmacognosy, School of Pharmacy, College of Medicine and
Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia.
(2)Department of Pharmaceutics and Pharmacoepidemiology, School of Pharmacy,
College of Health Sciences, Wollo University, Dessie, Ethiopia.
(3)Department of Biomedical Sciences, College of Veterinary Medicine and Animal
Sciences, University of Gondar, Gondar, Ethiopia.
DOI: 10.1155/2018/5109615
PMCID: PMC6151205
PMID: 30271635
Souza TG(1), Reiners AA, Azevedo RC, Fontes CJ, Ferreira RG, Do Carmo PU.
Author information:
(1)Federal University of Mato Grosso, Cuiabá, Brasil. taisa_guima@hotmail.com.
DOI: 10.3855/jidc.7129
PMID: 27886040 [Indexed for MEDLINE]
Author information:
(1)Department of Pharmacoepidemiology, Andrija Stampar Institute of Public
Health, Mirogojska 16, 10000 Zagreb, Croatia. marcel.leppee@stampar.hr.
(2)Department of Pharmacoepidemiology, Andrija Stampar Institute of Public
Health, Mirogojska 16, 10000 Zagreb, Croatia.
(3)Department of Pharmacology, School of Medicine, Josip Juraj Strossmayer
University Osijek, J. Huttlera 4, 31000 Osijek, Croatia.
(4)University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.
(5)Department of Anatomy, School of Medicine, University of Novi Sad, Hajduk
Veljkova 1-3, 21000 Novi Sad, Serbia.
OBJECTIVE: Older people receive medications for chronic diseases and therefore
adherence is an important health and economic concern. The objective of the study
is to determine relationships between pharmacist, patient and patient's family
physician with special emphasis on the comparison of adherent and non-adherent
patients.
METHODS: The study was designed as a cross-sectional survey by use of a
self-administered 33-item questionnaire. The study included 635 individuals
collecting or buying drugs for the treatment of chronic diseases and 84
pharmacists dispensing drugs for chronic diseases to patients.
RESULTS: The study included 265 (41.7%) adherent and 370 (58.3%) non-adherent
patients. Comparison of particular answers between patients and pharmacists
revealed a discrepancy, with a significant difference in five of eight answers.
The highest difference was recorded in answers to the question whether a
pharmacist offered thorough advice to the patient on how to take the drug; an
affirmative answer to this question was given by 90.5% of pharmacists and only
57.2% of patients. The analysis of respondents' claims about their relation with
one doctor shows that in the first place, with the highest number of positive
responses, is the claim of the respondents that their doctor always explains the
results of laboratory tests and other specialized findings (n = 489, 77.0%).
CONCLUSION: Enhancing communication between the physician, the pharmacist and the
patient is a key in boosting the patient's ability to follow a medication
regimen. Pharmacist-physician-patient relationship can improve adherence to
medication. It is very important to empower pharmacists to offer and allow time
for patient counselling.
DOI: 10.7727/wimj.2013.222
PMCID: PMC4668963
PMID: 25867560
Author information:
(1)a Department of Psychology , Stellenbosch University , Matieland , South
Africa.
DOI: 10.1080/13548506.2014.953962
PMCID: PMC4550101
PMID: 25168720 [Indexed for MEDLINE]
1922. Behav Brain Res. 2016 Jan 15;297:165-79. doi: 10.1016/j.bbr.2015.10.017. Epub
2015 Oct 20.
Author information:
(1)Department of Psychological and Brain Sciences, Boston University, Boston, MA
02215, USA.
(2)Department of Pharmaceutical Sciences, College of Pharmacy, University of
Kentucky, Lexington, KY 40536, USA.
(3)Department of Psychological and Brain Sciences, Boston University, Boston, MA
02215, USA. Electronic address: kkantak@bu.edu.
DOI: 10.1016/j.bbr.2015.10.017
PMCID: PMC4679481
PMID: 26467602 [Indexed for MEDLINE]
Najafi F(1)(2), Pasdar Y(1)(3), Shakiba E(4), Hamzeh B(1)(5), Darbandi M(6),
Moradinazar M(1)(2), Navabi J(4), Anvari B(4), Saidi MR(2), Bazargan-Hejazi S(7).
Author information:
(1)Research Center for Environmental Determinants of Health, Kermanshah
University of Medical Sciences, Kermanshah, Iran.
(2)Kermanshah Cardiovascular Research Center, Kermanshah University of Medical
Sciences, Kermanshah, Iran.
(3)Nutritional Sciences Department, School of Public Health, Kermanshah
University of Medical Sciences, Kermanshah, Iran.
(4)School of Medicine, Kermanshah University of Medical Sciences, Kermanshah,
Iran.
(5)Department of Public Health, Kermanshah University of Medical Sciences,
Kermanshah, Iran.
(6)Students Research Committee, Kermanshah University of Medical Sciences,
Kermanshah, Iran.
(7)Department of Psychiatry, Charles Drew University of Medicine and Science
(CDU), Los Angeles, CA, USA.
DOI: 10.3961/jpmph.18.257
PMCID: PMC6459766
PMID: 30971080 [Indexed for MEDLINE]
Wang J(1), Qiao Y, Shih YC, Jarrett-Jamison J, Spivey CA, Wan JY, White-Means SI,
Dagogo-Jack S, Cushman WC, Chisholm-Burns M.
Author information:
(1)University of Tennessee College of Pharmacy, 881 Madison Ave., Rm. 221,
Memphis, TN 38163. jwang26@uthsc.edu.
DOI: 10.18553/jmcp.2015.21.11.993
PMCID: PMC4631076
PMID: 26521111 [Indexed for MEDLINE]
1925. J Clin Med Res. 2018 Nov;10(11):806-814. doi: 10.14740/jocmr3557w. Epub 2018
Oct
9.
Peabody J(1)(2)(3), Acelajado MC(4), Robert T(5), Hild C(5), Schrecker J(5),
Paculdo D(3), Tran M(3), Jeter E(5).
Author information:
(1)University of California, San Francisco, CA, USA.
(2)University of California, Los Angeles, CA, USA.
(3)QURE Healthcare, San Francisco, CA, USA.
(4)Athens Limestone Hospital, Athens, AL, USA.
(5)Aegis Sciences Corporation, Nashville, TN, USA.
DOI: 10.14740/jocmr3557w
PMCID: PMC6188027
PMID: 30344815
Author information:
(1)Division of Clinical Informatics, Department of Medicine, Beth Israel
Deaconess Medical Center, Boston, Massachusetts, United States.
(2)Harvard Medical School, Boston, Massachusetts, United States.
DOI: 10.1055/s-0038-1660516
PMCID: PMC6010354
PMID: 29925099 [Indexed for MEDLINE]
Jelinek GA, Weiland TJ, Hadgkiss EJ, Marck CH, Pereira N, van der Meer DM.
DOI: 10.1179/1743132815Y.0000000036
PMCID: PMC4507477
PMID: 25905471 [Indexed for MEDLINE]
Qu D(1)(2)(3), Zhong X(1)(2)(3), Lai M(1)(2)(3), Dai J(4), Liang H(5), Huang
A(6).
Author information:
(1)1 Department of Epidemiology and Health Statistics, School of Public Health
and Management, Chongqing Medical University, China.
(2)2 Research Center for Medicine and Social Development, Chongqing Medical
University, China.
(3)3 Innovation Center for Social Risk Governance in Health, Chongqing Medical
University, China.
(4)4 Department of Epidemiology and Health Statistics, School of Public Health,
Xinjiang Medical University, China.
(5)5 Department of Epidemiology and Health Statistics, School of Public Health,
Guangxi Medical University, Nanning, China.
(6)6 Key Laboratory of Molecular Biology, Ministry of Molecular Biology,
Infectious Diseases, Medical University of Chongqing, China.
Iribarren S(1)(2), Siegel K(3), Hirshfield S(4), Olender S(5), Voss J(6),
Krongold J(1), Luft H(1), Schnall R(7).
Author information:
(1)School of Nursing, Columbia University, New York, NY, USA.
(2)Department of Biobehavioral Nursing and Health Informatics, School of Nursing,
University of Washington, Seattle, WA, USA.
(3)Department of Sociomedical Sciences, Mailman School of Public Health, Columbia
University, New York, NY, USA.
(4)Research and Evaluation Unit, Public Health Solutions, New York, NY, USA.
(5)College of Physicians and Surgeons, Columbia University, New York, NY, USA.
(6)Frances Payne Bolton School of Nursing, Case Western Reserve University,
Cleveland, OH, USA.
(7)School of Nursing, Columbia University, New York, NY, USA. rb897@columbia.edu.
People living with HIV (PLWH) are living longer, but many are now affected by
HIV-associated non-AIDS (HANA) conditions and their associated adverse symptoms.
An online survey was conducted with 769 PLWH with HANA conditions in the US.
Information was elicited on symptoms experienced, self-management strategies
employed, and the helpfulness of these strategies. Open ended responses were
collected for self-management strategies. A qualitative data analytic approach
was used to organize the 4036 self-management strategies into thematic
categories, with eight main categories emerging, including: taking medication,
modifying activity, altering diet, seeking help, waiting, substance use, managing
thoughts and attitudes, and altering the physical environment. Of the
self-management strategy subcategories, social support was the most helpful
self-management strategy with waiting/doing nothing being the least helpful
approach. Findings can be used to inform the development of self-management
interventions and to support health care professionals in recommending symptom
self-management strategies to their patients.
DOI: 10.1007/s10461-017-1786-6
PMCID: PMC5738289
PMID: 28488165 [Indexed for MEDLINE]
1930. BMC Health Serv Res. 2018 Feb 12;18(1):105. doi: 10.1186/s12913-018-2895-2.
Author information:
(1)Department of Health Sciences, University of Catanzaro "Magna Græcia", Via
Tommaso Campanella, 88100, Catanzaro, Italy.
(2)Department of Pharmacy, Health and Nutritional Sciences, University of
Calabria, Arcavacata di Rende, 87036, Cosenza, Italy.
(3)Department of Health Sciences, University of Catanzaro "Magna Græcia", Via
Tommaso Campanella, 88100, Catanzaro, Italy. pavia@unicz.it.
DOI: 10.1186/s12913-018-2895-2
PMCID: PMC5809870
PMID: 29433486 [Indexed for MEDLINE]
Author information:
(1)Department of Psychology, University of California, Berkeley, Berkeley, CA,
USA.
(2)Department of Psychology, University of Miami, Coral Gables, FL, USA.
DOI: 10.1111/sltb.12274
PMCID: PMC5788807
PMID: 27406282 [Indexed for MEDLINE]
Zargar AH(1).
Author information:
(1)Consultant Endocrinologist, Advanced Centre for Diabetes and Endocrine Care,
Srinagar, Jammu and Kashmir, India.
The discovery of insulin by Banting and Best in 1922 changed the landscape of
type 1 diabetes mellitus (T1DM). Guidelines on T1DM should be evidence based and
should emphasize comprehensive risk management. Guidelines would improve
awareness amongst governments, state health care providers and the general public
about the serious long-term implications of poorly managed diabetes and of the
essential resources needed for optimal care. T1DM requires lifelong daily
medication, regular control as well as access to facilities to manage acute and
chronic complications. American Diabetes Association 2014 guidelines recommends
annual nephropathy screening for albumin levels; random spot urine sample for
albumin-to-creatinine ratio at start of puberty or age ≥10 years, whichever is
earlier, once the child has had diabetes for 5 years. Hypertension should be
screened for in T1DM patients by measuring blood pressure at each routine visit.
Dyslipidemia in T1DM patients is important and patients should be screened if
there is a family history of hypercholesterolemia or a cardiovascular event
before the age of 55 years exists or if family history is unknown. Retinopathy is
another important complication of diabetes and patients should be subjected to an
initial dilated and comprehensive eye examination. Basic diabetes training should
be provided for school staff, and they should be assigned with responsibilities
for the care of diabetic children. Self-management should be allowed at all
school settings for students.
DOI: 10.4103/2230-8210.155355
PMCID: PMC4413379
PMID: 25941640
Lansing AH(1), Stanger C(2), Crochiere R(2), Carracher A(3), Budney A(2).
Author information:
(1)Geisel School of Medicine at Dartmouth, 46 Centerra Pkwy., Suite 301, Lebanon,
NH, 03766, USA. amy.hughes.lansing@dartmouth.edu.
(2)Geisel School of Medicine at Dartmouth, 46 Centerra Pkwy., Suite 301, Lebanon,
NH, 03766, USA.
(3)Dartmouth College, Hanover, NH, USA.
DOI: 10.1007/s10865-017-9856-9
PMCID: PMC5681872
PMID: 28500504 [Indexed for MEDLINE]
1934. Pain Med. 2014 Oct;15(10):1757-64. doi: 10.1111/pme.12416. Epub 2014 Mar 10.
The association between catastrophizing and craving in patients with chronic pain
prescribed opioid therapy: a preliminary analysis.
Author information:
(1)Department of Anesthesiology, Harvard Medical School, Brigham & Women's
Hospital, Boston, Massachusetts, USA.
BACKGROUND: A growing number of studies have shown that opioid craving (i.e., the
perceived need or desire to consume opioids) is one of the strongest determinants
of prescription opioid misuse in patients with chronic pain prescribed opioid
therapy. To date, however, the factors that are associated with craving in
patients with pain remain largely unexplored. Based on previous research, there
is reason to believe that catastrophizing might be associated with heightened
opioid craving.
OBJECTIVES: To test the hypothesis that catastrophizing would be associated with
heightened craving in patients with chronic pain prescribed long-term opioid
therapy.
DESIGN AND SUBJECTS, AND METHODS: In this cross-sectional study, 109 patients
with chronic pain were asked to provide self-reports of catastrophizing and
craving. Patients also provided self-reports of pain intensity and depressive
symptoms.
RESULTS: We found that higher levels of catastrophizing were associated with
higher levels of craving. Importantly, results of a regression analysis revealed
that the association between catastrophizing and craving remained significant
even after controlling for a host of demographic (i.e., age, sex), psychological
(i.e., depressive symptoms), medical (i.e., pain intensity, pain duration), and
medication regimen (i.e., opioid doses) variables.
CONCLUSIONS: Our preliminary findings provide valuable new insights into the
determinants of craving in patients with pain. The finding that catastrophizing
was associated with craving even after controlling for a host of demographic,
psychological, medical, and medication regimen variables is particularly
striking, and raises questions concerning the factors that underlie the
association between catastrophizing and craving in patients prescribed opioid
therapy.
DOI: 10.1111/pme.12416
PMCID: PMC4160420
PMID: 24612286 [Indexed for MEDLINE]
Guerzoni S(1), Pellesi L(1), Baraldi C(1), Cainazzo MM(1), Negro A(2),
Martelletti P(2), Pini LA(1)(3).
Author information:
(1)Headache and Drug Abuse Research Centre, Policlinico Hospital, Department of
Diagnostic Medicine, Clinical and Public Health, University of Modena e Reggio
Emilia, Modena, Italy.
(2)Regional Referral Headache Centre, Sant'Andrea Hospital, Department of
Clinical and Molecular Medicine, Sapienza University, Rome, Italy.
(3)Center for Neuroscience and Neurotechnology, Department of Biomedical,
Metabolic and Neural Sciences, University of Modena e Reggio Emilia, Modena,
Italy.
Background: Chronic migraine (CM) affects about the 2% of the general population
and it has been recognized as one of the most-disabling conditions worldwide by
the World Health Organization. CM is often associated with the overuse of
abortive medication, which determines the worsening of headache itself and the
development of a secondary headache called medication overuse headache. The
management of these associated conditions is difficult, but a growing amount of
evidence is pointing out the effectiveness and the good safety profile of
OnabotulinumtoxinA (OnabotA). Despite this, data on OnabotA effects and safety in
long-term use lack. The purpose of the present article is to retrospectively
assess the efficacy and safety of OnabotA in a cohort of chronic migraineurs with
drug overuse from the 18th month of treatment until the third year.
Materials and methods: 90 chronic migraineurs with medication overuse were
enrolled between January 2013 and February 2017. All patients were treated with
OnabotA according to PREEMPT dictates. Before every injection session the
headache index, the analgesic consumption, the visual analog scale for pain
score, the 36-items short form health survey questionnaire score, the 6-items
headache impact test (HIT-6) score and the Zung self-rating anxiety and
depression scale scores were collected. Adverse events were carefully registered.
A simple linear regression was performed to explore the mean changes in the
abovementioned parameters for a single injection session and mean comparison
tests were performed using the one-way analysis of variance followed by
Tukey-Kramer post-hoc test.
Results: A significantly improvement for a single injection was registered for
all the above-mentioned parameters. Headache index, analgesic consumption, visual
analog pain scale, and 6-items HIT-6 scores were significantly lower than
baseline from the 18th month of treatment onwards. The 36-items short form health
survey questionnaire scores were significantly higher than baseline at every
injections session from the 18th months onwards. Zung scales did not change. No
serious adverse events were assessed and no adverse events-related drop-outs were
seen.
Conclusion: OnabotA effectiveness and safety last until 3 years of therapy,
raising the possibility of the use of this therapy even for many years in CM
prevention.
DOI: 10.3389/fneur.2017.00586
PMCID: PMC5676047
PMID: 29163347
McAuley JW(1), Passen N(2), Prusa C(2), Dixon J(2), Cotterman-Hart S(3), Shneker
BF(4).
Author information:
(1)Ohio State University College of Pharmacy, Columbus, OH 43210, USA; Ohio State
University College of Medicine, Columbus, OH 43210, USA. Electronic address:
McAuley.5@osu.edu.
(2)Ohio State University College of Pharmacy, Columbus, OH 43210, USA.
(3)Ohio State University College of Medicine, Columbus, OH 43210, USA.
(4)Ohio State University College of Medicine, Columbus, OH 43210, USA; Ohio State
University College of Pharmacy, Columbus, OH 43210, USA.
RATIONALE: Antiepileptic drugs are the mainstay of treatment for patients with
epilepsy. Adherence to the prescribed regimen is a major factor in achieving a
reduced seizure burden, which can decrease morbidity and mortality. Patients with
epilepsy oftentimes complain about difficulty with memory. Because little is
known about the relationship between memory and mood and adherence, the purpose
of this project was to determine the impact of the confounding factors of memory
and mood on antiepileptic drug adherence in patients with epilepsy.
METHODS: One hundred adult patients with epilepsy were recruited from the
outpatient neurology clinic for this cross-sectional study. Patients who met the
inclusion criteria completed measures of subjective memory (subset of 6 memory
questions from the QOLIE-89) and objective memory (Hopkins Verbal Learning Test -
Revised), subjective adherence (Morisky scale) and objective adherence
(medication possession ratio), and mood (Neurological Disorders Depression
Inventory for Epilepsy). Refill records from each patient's community pharmacy
were used to objectively assess adherence. Medication possession ratios were
calculated based on the antiepileptic drug refill records over the previous
6months. Patients were considered adherent if their MPR was >80%.
RESULTS: Women made up the majority of the sample (n=59), and, on average,
patients had been living with epilepsy for nearly 20years. Approximately 40% of
the sample were on antiepileptic drug monotherapy; most patients (>70%) took
their antiepileptic drugs twice daily, and the mean number of total medications
was 4.25±2.98. Based on the objective measure of adherence, 35% of the patients
were nonadherent. Patients self-reported better adherence than what was
objectively measured. Only the retention metric of the objective memory measure
differentiated adherent patients from nonadherent patients. Patients in the
adherent group had significantly lower depression scores (indicating better mood)
compared with those in the nonadherent group (p=0.04).
CONCLUSIONS: Objective memory measures were not robustly correlated with
adherence. However, we observed that patients with higher depressed mood scores
were more likely to be nonadherent. By targeting patients with epilepsy and
comorbid depression, practitioners may identify patients at greatest risk of
nonadherence and subsequent harm.
DOI: 10.1016/j.yebeh.2014.11.017
PMID: 25561379 [Indexed for MEDLINE]
Author information:
(1)CI&DETS (PEst-OE/CED/UI4016/2014) - Escola Superior de Saúde, Instituto
Politécnico de Viseu, Viseu, Portugal. Electronic address:
madureiradias@gmail.com.
(2)CI&DETS (PEst-OE/CED/UI4016/2014) - Escola Superior de Saúde, Instituto
Politécnico de Viseu, Viseu, Portugal.
(3)Escola Superior de Enfermagem de Vila Real - Escola Superior de Enfermagem de
Vila Real, Universidade de Trás-os-Montes e Alto Douro, Vila Real, Portugal.
(4)Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Escola
Superior de Enfermagem do Porto, Porto, Portugal.
DOI: 10.1016/S0212-6567(14)70074-5
PMID: 25476044 [Indexed for MEDLINE]
1938. Patient Prefer Adherence. 2018 Dec 18;13:9-19. doi: 10.2147/PPA.S182765.
eCollection 2019.
Katzmann JL(1), Mahfoud F(2), Böhm M(2), Schulz M(3)(4), Laufs U(1).
Author information:
(1)Department of Cardiology, Universitätsklinikum Leipzig, Leipzig, Germany,
julius.katzmann@medizin.uni-leipzig.de.
(2)Medical Clinic III, Cardiology, Angiology, Intensive Care,
Universitätsklinikum des Saarlandes, Homburg, Germany.
(3)Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie
Universität Berlin, Berlin, Germany.
(4)Department of Medicine, ABDA - Federal Union of German Associations of
Pharmacists, Berlin, Germany.
Background: Many patients at high cardiovascular risk do not reach targets for
low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP). Depression
is a frequent comorbidity in these patients and contributes to poor medication
adherence.
Objective: The aim of this study was to elucidate the associations between
adherence to lipid-and BP-lowering drugs, the diagnosis of depression, and the
control of LDL-C and BP.
Patients and methods: This study was conducted as multicenter, single-visit
cross-sectional study in Germany. Adherence was assessed by the Morisky
Medication Adherence Scale-8 (MMAS-8), and depression was assessed as documented
in the patient chart.
Results: A total of 3,188 ambulatory patients with hypercholesterolemia (39.8%),
stable coronary artery disease (CAD; 7.4%), or both (52.9%) were included.
Patients had a history of myocardial infarction (30.8%), diabetes (42.0%), were
smokers (19.7%), and 16.1% had the investigator-reported diagnosis of depression.
High or moderate adherence to lipid-lowering medication compared to low adherence
was associated with lower LDL-C levels (105.5±38.3 vs 120.8±42.4 mg/dL) and lower
BP (systolic BP 133.4±14.5 vs 137.9±13.9 mmHg, diastolic BP 78.3±9.6 vs 81.8±9.6
mmHg) and with a higher proportion of patients achieving the
guideline-recommended LDL-C (16.9% vs 10.1%) and BP target (52.2% vs 40.8%, all
comparisons P<0.0001). Adherence was worse in patients with depression.
Correspondingly, patients with depression showed higher LDL-C levels, higher BP,
and a lower probability of achieving the LDL-C and BP goal. Medication adherence
correlated between BP- and lipid-lowering medications.
Conclusion: Self-reported medication adherence can be easily obtained in daily
practice. A low adherence and the diagnosis of depression identify patients at
risk for uncontrolled LDL-C and BP who likely benefit from intensified care.
DOI: 10.2147/PPA.S182765
PMCID: PMC6302826
PMID: 30587940
Author information:
(1)Cancer Prevention and Control Program, Department of Oncology, Lombardi
Comprehensive Cancer Center, 3300 Whitehaven St., NW Suite 4100, Washington, DC,
20007, USA. ahd28@georgetown.edu.
(2)Cancer Prevention and Control Program, Department of Oncology, Lombardi
Comprehensive Cancer Center, 3300 Whitehaven St., NW Suite 4100, Washington, DC,
20007, USA.
(3)Department of Health Behavior and Policy, Virginia Commonwealth University,
School of Medicine, 830 East Main Street, Richmond, VA, 23219, USA.
DOI: 10.1007/s13187-017-1180-0
PMCID: PMC5557694
PMID: 28205022 [Indexed for MEDLINE]
Manze MG(1), Orner MB(2), Glickman M(3), Pbert L(4), Berlowitz D(3), Kressin
NR(5).
Author information:
(1)Hunter College, City University of New York (CUNY) School of Public Health,
New York, USA. Electronic address: meredith.manze@hunter.cuny.edu.
(2)Center for Healthcare Organization and Implementation Research, Bedford VAMC,
Bedford, USA.
(3)Center for Healthcare Organization and Implementation Research, Bedford VAMC,
Bedford, USA; Health Policy and Management Department, Boston University School
of Public Health, Boston, USA.
(4)University of Massachusetts Medical School, Worcester, USA.
(5)VA Boston Healthcare System, Boston, USA; Section of General Internal
Medicine, Boston University School of Medicine, Boston, USA.
DOI: 10.1016/j.pec.2014.10.014
PMCID: PMC4282944
PMID: 25468397 [Indexed for MEDLINE]
Obermeier MC, Sikka RS, Tompkins M, Nelson BJ, Hamilton A, Reams M, Chmielewski
TL.
BACKGROUND: Few studies have documented early functional recovery after anterior
cruciate ligament (ACL) reconstruction.
PURPOSE: To quantify the time to early functional milestone achievement and
change in function over 12 weeks after ACL reconstruction and to identify
demographic characteristic predictors of the outcomes.
STUDY DESIGN: Prospective, longitudinal, observational study.
LEVEL OF EVIDENCE: Level 4.
METHODS: A total of 182 patients (95 females, 87 males; mean ± SD age, 28 ± 12
years; mean ± SD body mass index [BMI], 25 ± 4 kg/m2) who received primary,
unilateral, ACL reconstruction were included. Testing occurred before surgery as
well as 1, 2, 4, 8, and 12 weeks postsurgery. Outcomes included demographic
characteristics, self-reported functional milestone achievements and responses on
the Short Musculoskeletal Function Assessment (SMFA) questionnaire. Time to
functional milestone achievement was calculated, and patients were categorized
into "faster" or "prolonged" recovery groups based on the median value.
Longitudinal change in SMFA subscale scores (daily activities and mobility) as
well as demographic predictors of functional recovery group assignment and
postsurgical change in SMFA subscale scores were examined.
RESULTS: Median time for discontinuing narcotic pain medication was 9 days, while
that for discontinuing crutches was 15 days. Time to return to work occurred at a
median of 11 days, return to school at 7 days, and return to driving at 11 days.
Both SMFA subscale scores significantly decreased (improved) over time, with the
greatest change occurring between 1 and 4 weeks postsurgery. The demographic
predictor of faster functional recovery for discontinuation of narcotic pain
medication was surgery with allograft; those for return to work were higher age,
male sex, decreasing BMI, and sedentary/light occupational demand; and those for
return to driving were higher age, male sex, and surgery on the left side of the
body.
CONCLUSION: Functional recovery occurs rapidly over the first month after ACL
reconstruction for most patients. Nonmodifiable demographic characteristics may
influence recovery time for specific functional milestones.
CLINICAL RELEVANCE: Results can be used to counsel patients on early functional
recovery after ACL reconstruction.
DOI: 10.1177/1941738118779762
PMCID: PMC6044123
PMID: 29863963 [Indexed for MEDLINE]
1942. Pharmacy (Basel). 2018 Jan 22;6(1). pii: E11. doi: 10.3390/pharmacy6010011.
Author information:
(1)Department of Pharmacy Practice and Science, University of Arizona College of
Pharmacy, Tucson, AZ 85721, USA. axon@pharmacy.arizona.edu.
(2)Department of Pharmacy Practice and Science, University of Arizona College of
Pharmacy, Tucson, AZ 85721, USA. chernandez@pharmacy.arizona.edu.
(3)Department of Pharmacy Practice and Science, University of Arizona College of
Pharmacy, Tucson, AZ 85721, USA. jlee@pharmacy.arizona.edu.
(4)Department of Pharmacy Practice and Science, University of Arizona College of
Pharmacy, Tucson, AZ 85721, USA. slack@pharmacy.arizona.edu.
DOI: 10.3390/pharmacy6010011
PMCID: PMC5874550
PMID: 29361750
Dunbar SB(1), Clark PC(2), Stamp KD(3), Reilly CM(1), Gary RA(1), Higgins M(1),
Kaslow N(4).
Author information:
(1)Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
(2)Georgia State University, Byrdine F. Lewis School of Nursing, Atlanta, GA,
USA.
(3)Boston College, School of Nursing, Chestnut Hill, MA 02467, USA. Electronic
address: stampk@bc.edu.
(4)School of Medicine, Emory University, Atlanta, GA, USA.
DOI: 10.1016/j.hrtlng.2016.04.001
PMCID: PMC4935570
PMID: 27174641 [Indexed for MEDLINE]
Agot K(1), Taylor D, Corneli AL, Wang M, Ambia J, Kashuba AD, Parker C, Lemons A,
Malahleha M, Lombaard J, Van Damme L.
Author information:
(1)Impact Research and Development Organization, P.O. Box 9171-40141, Kisumu,
Kenya, mamagifto@yahoo.com.
DOI: 10.1007/s10461-014-0859-z
PMCID: PMC4415940
PMID: 25100053 [Indexed for MEDLINE]
Niikura R(1), Yamada A(1), Hirata Y(1), Hayakawa Y(1), Takahashi A(2), Shinozaki
T(3), Takeuchi Y(3), Fujishiro M(1)(4), Koike K(1).
Author information:
(1)Department of Gastroenterology, Graduate School of Medicine, The University of
Tokyo, Japan.
(2)Department of Gastroenterology, The Japan Association for Development of
Community Medicine Nerimahikarigaoka Hospital, Japan.
(3)Department of Biostatistics, School of Public Health, Graduate School of
Medicine, The University of Tokyo, Japan.
(4)Department of Endoscopy and Endoscopic Surgery, The University of Tokyo
Hospital, Japan.
DOI: 10.2169/internalmedicine.0492-17
PMCID: PMC6172555
PMID: 29607951 [Indexed for MEDLINE]
Tanda G(1), Mereu M(1), Hiranita T(2), Quarterman JC(1), Coggiano M(1), Katz
JL(2).
Author information:
(1)Medication Development Program, Molecular Targets and Medication Discovery
Branch, NIDA-IRP, NIH/DHHS, Baltimore, MD, USA.
(2)Psychobiology Section, Molecular Neuropsychiatry Research Branch, NIDA-IRP,
NIH/DHHS, Baltimore, MD, USA.
Comment in
J Alcohol Drug Depend. 2016 Dec;4(6):.
Effective medications for drug abuse remain a largely unmet goal in biomedical
science. Recently, the (+)-enantiomers of naloxone and naltrexone, TLR4
antagonists, have been reported to attenuate preclinical indicators of both
opioid and stimulant abuse. To further examine the potential of these compounds
as drug-abuse treatments, we extended the previous assessments to include a wider
range of doses and procedures. We report the assessment of (+)-naloxone and
(+)-naltrexone on the acute dopaminergic effects of cocaine and heroin determined
by in vivo microdialysis, on the reinforcing effects of cocaine and the opioid
agonist, remifentanil, tested under intravenous self-administration procedures,
as well as the subjective effects of cocaine determined by
discriminative-stimulus effects in rats. Pretreatments with (+)-naloxone or
(+)-naltrexone did not attenuate, and under certain conditions enhanced the
stimulation of dopamine levels produced by cocaine or heroin in the nucleus
accumbens shell. Furthermore, although an attenuation of either cocaine or
remifentanil self-administration was obtained at the highest doses of
(+)-naloxone and (+)-naltrexone, those doses also attenuated rates of
food-maintained behaviors, indicating a lack of selectivity of TLR4 antagonist
effects for behaviors reinforced with drug injections. Drug-discrimination
studies failed to demonstrate a significant interaction of (+)-naloxone with
subjective effects of cocaine. The present studies demonstrate that under a wide
range of doses and experimental conditions, the TLR4 antagonists, (+)-naloxone
and (+)-naltrexone, did not specifically block neurochemical or behavioral
abuse-related effects of cocaine or opioid agonists.
DOI: 10.1038/npp.2016.91
PMCID: PMC5026747
PMID: 27296151 [Indexed for MEDLINE]
McCoy K(1), Waldrop-Valverde D(2), Balderson BH(3), Mahoney C(3), Catz S(4).
Author information:
(1)University of Washington Bothell, School of Nursing & Health Studies, Bothell,
WA, USA kmccoy@uw.edu.
(2)Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
(3)Group Health Research Institute, Seattle, WA, USA.
(4)Group Health Research Institute, Seattle, WA, USA University of California
Davis Health System, Sacramento, CA, USA.
DOI: 10.1177/2325957416642019
PMCID: PMC4869721
PMID: 27071744 [Indexed for MEDLINE]
Author information:
(1)Dobney Hypertension Centre, School of Medicine - Royal, Perth Hospital
Unit/Medical Research Foundation, University of Western Australia, Crawley WA,
Australia.
(2)Departments of Cardiology and Nephrology, Royal Perth Hospital, Perth,
Australia.
(3)Neurovascular Hypertension & Kidney Disease Laboratory, Baker Heart and
Diabetes Institute, Melbourne, Australia.
Comment on
Lancet. 2018 Mar 10;391(10124):949-959.
DOI: 10.21037/cdt.2018.08.01
PMCID: PMC6382658
PMID: 30881886
Author information:
(1)Department of Clinical Neuroscience and Rehabilitation Medicine, Sahlgrenska
Academy, University of Gothenburg, Institute of Neuroscience and Physiology, ,
413 45 Göteborg, Sweden. elisabeth.brodin@gu.se.
DOI: 10.2340/16501977-2353
PMID: 29881866 [Indexed for MEDLINE]
A survey on awareness of the "finger-tip unit" and medication guidance for the
use of topical steroids among community pharmacists.
Oishi N(1), Iwata H(1), Kobayashi N(1), Fujimoto K(1), Yamaura K(1).
Author information:
(1)Division of Social Pharmacy, Center for Social Pharmacy and Pharmaceutical
Care Sciences, Faculty of Pharmacy, Keio University.
DOI: 10.5582/ddt.2019.01007
PMID: 31204366
Beer L, Skarbinski J.
Erratum in
AIDS Educ Prev. 2015 Oct;27(5):489-91.
DOI: 10.1521/aeap.2014.26.6.521
PMCID: PMC4579321
PMID: 25490733 [Indexed for MEDLINE]
1952. Ann Intern Med. 2017 Nov 21;167(10):689-697. doi: 10.7326/M17-1150. Epub 2017
Nov
7.
Belknap R(1), Holland D(1), Feng PJ(1), Millet JP(1), Caylà JA(1), Martinson
NA(1), Wright A(1), Chen MP(1), Moro RN(1), Scott NA(1), Arevalo B(1), Miró
JM(1), Villarino ME(1), Weiner M(1), Borisov AS(1); TB Trials Consortium iAdhere
Study Team.
Author information:
(1)From Denver Health and Hospital Authority and the University of Colorado
Health Sciences Center, Denver, Colorado; Emory University and Fulton County
Department of Health and Wellness, Atlanta, Georgia; Centers for Disease Control
and Prevention, Atlanta, Georgia; Public Health Agency of Barcelona and CIBER de
Epidemiología y Salud Pública, Barcelona, Spain; University of the Witwatersrand,
Johannesburg, South Africa; Vanderbilt University, Nashville, Tennessee; Westat,
Fort Lauderdale, Florida; University of Barcelona, Barcelona, Spain; and
University of Texas Health Science Center and Veterans Administration Medical
Center, San Antonio, Texas.
Comment in
Ann Intern Med. 2017 Nov 21;167(10 ):742-743.
DOI: 10.7326/M17-1150
PMCID: PMC5766341
PMID: 29114781 [Indexed for MEDLINE]
1953. Pharmacy (Basel). 2019 Jul 11;7(3). pii: E88. doi: 10.3390/pharmacy7030088.
Author information:
(1)Department of Pharmacy Administration and Public Health, College of Pharmacy
and Health Sciences, St. John's University, 8000 Utopia Parkway, Jamaica, NY
11439, USA. shaquib.hasan111@gmail.com.
(2)Department of Pharmacy Administration and Public Health, College of Pharmacy
and Health Sciences, St. John's University, 8000 Utopia Parkway, Jamaica, NY
11439, USA.
The study purpose was to use the theory of planned behavior to understand factors
influencing South Asian consumers' intention to seek pharmacist-provided
medication therapy management services (MTMS). Specific objectives were to assess
effects of attitude, subjective norm (SN), perceived behavioral control (PBC),
and socio-demographics on South Asian consumers' intention to seek MTMS.
Participants who were ≥18 years of age, of South Asian origin, with a previous
visit to a pharmacy in the US for a health-related reason, and with ability to
read and comprehend English were recruited from independent pharmacies in New
York City. Responses were obtained through a self-administered survey.
Descriptive statistics were performed, and multiple linear regression analysis
was conducted to assess the study objective. SPSS was used for data analyses. Out
of 140 responses, 133 were usable. Mean scores (standard deviation) were 4.04
(0.97) for attitude, 3.77 (0.91) for SN, 3.75 (0.93) for PBC, and 3.96 (0.94) for
intention. The model explains 80.8% of variance and is a significant predictor of
intention, F (14,118) = 35.488, p < 0.05. While attitude (β = 0.723, p < 0.05)
and PBC (β = 0.148, p < 0.05) were significant predictors of intention, SN (β =
0.064, p = 0.395) was not. None of the socio-demographics were significant
predictors of intention. Strategies to make South Asians seek MTMS should focus
on creating positive attitudes and removing barriers in seeking MTMS.
DOI: 10.3390/pharmacy7030088
PMID: 31373281
Author information:
(1)1 Arnold School of Public Health, University of South Carolina, Columbia.
(2)2 University of Florida College of Medicine, Gainesville.
DOI: 10.18553/jmcp.2018.24.1.56
PMID: 29290172 [Indexed for MEDLINE]
Shams N(1), Amjad S(2), Kumar N(3), Ahmed W(1), Saleem F(4).
Author information:
(1)Department of Medicine, Rawal Institute of Health Sciences, Islamabad,
Pakistan.
(2)Benazir Bhutto Shaheed Hospital, Rawalpindi, Pakistan.
(3)Dow University of Health Sciences, Karachi, Pakistan.
(4)International Medical City Hospital, East Riffa, Bahrain.
Knowledge and disclosure of HIV status among adolescents and young adults
attending an adolescent HIV clinic in Accra, Ghana.
Author information:
(1)Korle-Bu Teaching Hospital, Accra, Ghana. Ernest_kenu@yahoo.com.
DOI: 10.1186/1756-0500-7-844
PMCID: PMC4256736
PMID: 25424862 [Indexed for MEDLINE]
Author information:
(1)Department of Psychosomatic Medicine and Psychotherapy, University Medical
Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; German Center
for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany.
DOI: 10.1111/jth.12743
PMID: 25292317 [Indexed for MEDLINE]
A model of parental distress and factors that mediate its link with parental
monitoring of youth diabetes care, adherence, and glycemic control.
Robinson EM(1), Weaver P(2), Chen R(3), Streisand R(4), Holmes CS(5).
Author information:
(1)Department of Psychology, Virginia Commonwealth University.
(2)Department of Psychology, Eastern Michigan University.
(3)Center For New Designs In Learning and Scholarship, Georgetown University.
(4)Department of Psychiatry and Behavioral Sciences, Division of Behavioral
Medicine and Clinical Psychology, Children's National Medical Center.
(5)Department of Pediatrics, Virginia Commonwealth University.
DOI: 10.1037/hea0000406
PMCID: PMC5118052
PMID: 27513476 [Indexed for MEDLINE]
1959. J Atten Disord. 2016 Jan 28. pii: 1087054715624227. [Epub ahead of print]
Gordon MK(1), Baum RA(2), Gardner W(3), Kelleher KJ(4), Langberg JM(5), Brinkman
WB(6), Epstein JN(6).
Author information:
(1)University of Illinois at Chicago, IL, USA megangordon448@gmail.com.
(2)The Ohio State University, Columbus, USA.
(3)Children's Hospital of Eastern Ontario, Ottawa, Canada.
(4)Nationwide Children's Hospital, Columbus, OH, USA.
(5)Virginia Commonwealth University, Richmond, USA.
(6)Cincinnati Children's Hospital Medical Center, OH, USA.
DOI: 10.1177/1087054715624227
PMCID: PMC5019953
PMID: 26823383
Author information:
(1)The University of Sydney School of Pharmacy, Sydney, NSW, Australia,
psri6621@uni.sydney.edu.au.
DOI: 10.2147/PPA.S160728
PMCID: PMC6159805
PMID: 30288027
1961. Toxins (Basel). 2019 Aug 29;11(9). pii: E504. doi: 10.3390/toxins11090504.
Gandolfi M(1)(2), Donisi V(3), Marchioretto F(4), Battista S(5), Smania N(5)(6),
Del Piccolo L(3).
Author information:
(1)Department of Neurosciences, Biomedicine and Movement Sciences, University of
Verona, 37134 Verona, Italy. marialuisa.gandolfi@univr.it.
(2)UOC Neurorehabilitation, AOUI Verona, 37134 Verona, Italy.
marialuisa.gandolfi@univr.it.
(3)Section of Clinical Psychology, Department of Neurosciences, Biomedicine and
Movement Sciences, University of Verona, 37134 Verona, Italy.
(4)Unit of Neurology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, 37024
Verona, Italy.
(5)Department of Neurosciences, Biomedicine and Movement Sciences, University of
Verona, 37134 Verona, Italy.
(6)UOC Neurorehabilitation, AOUI Verona, 37134 Verona, Italy.
1962. Can J Hosp Pharm. 2018 Jul-Aug;71(4):227-233. Epub 2018 Aug 28.
Author information:
(1), PharmD, MSc, is a Pharmacist with the Hôpital général juif Sir Mortimer B.
Davis, Montréal, Quebec.
(2), BScPharm, PharmD, is a Drug Use Evaluation Pharmacist with Canadian Forces
Health Services Group Headquarters, Ottawa, Ontario.
PMCID: PMC6118825
PMID: 30185996
Salyers MP(1), Fukui S(1), Bonfils KA(1), Firmin RL(1), Luther L(1), Goscha R(1),
Rapp CA(1), Holter MC(1).
Author information:
(1)Dr. Salyers, Ms. Bonfils, Ms. Firmin, and Ms. Luther are with the Department
of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis
(e-mail: mpsalyer@iupui.edu ). Dr. Fukui, Dr. Goscha, and Dr. Rapp are with the
School of Social Welfare, University of Kansas, Lawrence, where Dr. Holter was
affiliated when this work was done.
OBJECTIVE: The authors examined consumer outcomes before and after implementing
CommonGround, a computer-based shared decision-making program.
METHODS: Consumers with severe mental illness (N=167) were interviewed prior to
implementation and 12 and 18 months later to assess changes in active treatment
involvement, symptoms, and recovery-related attitudes. Providers also rated
consumers on level of treatment involvement.
RESULTS: Most consumers used CommonGround at least once (67%), but few used the
program regularly. Mixed-effects regression analyses showed improvement in
self-reported symptoms and recovery attitudes. Self-reported treatment
involvement did not change; however, for a subset of consumers with the same
providers over time (N=83), the providers rated consumers as more active in
treatment.
CONCLUSIONS: This study adds to the growing literature on tools to support shared
decision making, showing the potential benefits of CommonGround for improving
recovery outcomes. More work is needed to better engage consumers in CommonGround
and to test the approach with more rigorous methods.
DOI: 10.1176/appi.ps.201500468
PMCID: PMC5658777
PMID: 27903137 [Indexed for MEDLINE]
1964. Pain Res Manag. 2015 Sep-Oct;20(5):241-8. Epub 2015 Jun 30.
Modifiable lifestyle factors are associated with lower pain levels in adults with
knee osteoarthritis.
Connelly AE, Tucker AJ, Kott LS, Wright AJ, Duncan AM.
DOI: 10.1155/2015/389084
PMCID: PMC4596631
PMID: 26125195 [Indexed for MEDLINE]
Author information:
(1)Universidade do Vale do Rio dos Sinos. Programa de Pós-Graduação em Saúde
Coletiva. São Leopoldo, RS, Brasil.
DOI: 10.11606/S1518-8787.2017051006932
PMCID: PMC5697919
PMID: 29166445 [Indexed for MEDLINE]
Bolmsjö BB(1), Palagyi A(2), Keay L(2), Potter J(3), Lindley RI(2).
Author information:
(1)Department for Clinical Sciences, Lund University, Malmö, Sweden.
beata.borgstrom-bolmsjo@med.lu.se.
(2)The George Institute for Global Health, Sydney Medical School, University of
Sydney, Sydney, NSW, Australia.
(3)Illawarra Health and Medical Research Institute, University of Wollongong,
Wollongong, NSW, Australia.
BACKGROUND: General Practitioners (GPs) are responsible for primary prescribing
decisions in most settings. Elderly patients living in Advanced Care Facilities
(ACFs) often have significant co-morbidities to consider when selecting an
appropriate drug therapy. Careful assessment is required when considering
appropriate medication use in frail older patients as they have multiple diseases
and thus multiple medication. Many physicians seem reluctant to discontinue other
physicians' prescriptions, resulting in further polypharmacy. Therefore it is
relevant to ascertain and synthesise the GP views from multiple settings to
understand the processes that might promote appropriate deprescribing medications
in the elderly. The aims of this study were to 1) compare and contrast
behavioural factors influencing the deprescribing practices of GPs providing care
for ACF residents in two separate countries, 2) review health policy and ACF
systems in each setting for their potential impact on the prescribing of
medications for an older person in residential care of the elderly, and 3) based
on these findings, provide recommendations for future ACF deprescribing
initiatives.
METHODS: A review and critical synthesis of qualitative data from two interview
studies of knowledge, attitudes, and behavioural practices held by GPs towards
medication management and deprescribing for residents of ACFs in Australia and
Sweden was conducted. A review of policies and health care infrastructure was
also carried out to describe the system of residential aged care in the both
countries.
RESULTS: Our study has identified that deprescribing by GPs in ACFs is a complex
process and that there are numerous barriers to medication reduction for aged
care residents in both countries, both with similarities and differences. The
factors affecting deprescribing behaviour were identified and divided into:
intentions, skills and abilities and environmental factors.
CONCLUSIONS: In this study we show that the GPs' behaviour of deprescribing in
two different countries is much dependent on the larger health care system. There
is a need for more education to both GPs and ACF staff as well as better
cooperation between the different health care systems and appropriate monetary
incentives for elderly care to achieve better conditions for deprescribing
practice.
DOI: 10.1186/s12875-016-0551-7
PMCID: PMC5097406
PMID: 27814691 [Indexed for MEDLINE]
1967. MMWR Morb Mortal Wkly Rep. 2019 Jan 4;67(5152):1405-1409. doi:
10.15585/mmwr.mm675152a1.
Baugher AR, Beer L, Bradley HM, Evans ME, Luo Q, Shouse RL.
DOI: 10.15585/mmwr.mm675152a1
PMCID: PMC6334823
PMID: 30605445 [Indexed for MEDLINE]
Conflict of interest statement: All authors have completed and submitted the
ICMJE form for disclosure of potential conflicts of interest. No potential
conflicts of interest were disclosed.
Cost of opioid medication abuse with and without tampering in the USA.
Author information:
(1)Health Outcomes Practice, Kantar Health, Horsham, PA, USA,
jeffrey.vietri@pfizer.com.
(2)Health Economics & Outcomes Research, Pfizer Inc., New York, NY, USA.
(3)Statistical Research & Data Science Center, Pfizer Inc., New York, NY, USA.
DOI: 10.2147/CEOR.S168145
PMCID: PMC6089114
PMID: 30127632
Davis RT(1), Badger G(1), Valentine K(2), Cavert A(2), Coeytaux RR(3).
Author information:
(1)Acupuncture Vermont, South Burlington, Vermont.
(2)2Larner College of Medicine, University of Vermont, South Burlington, Vermont.
(3)3Wake Forest University School of Medicine, Winston-Salem, North Carolina.
DOI: 10.1177/2164956118769557
PMCID: PMC5896847
PMID: 29662722
Gardiner P(1), Sadikova E(2), Filippelli AC(2), White LF(3), Jack BW(2).
Author information:
(1)Department of Family Medicine, Boston University School of Medicine, Boston
Medical Center, Boston, USA. Electronic address: Paula.gardiner@bmc.org.
(2)Department of Family Medicine, Boston University School of Medicine, Boston
Medical Center, Boston, USA.
(3)Department of Biostatistics, Boston University School of Public Health,
Boston, USA.
DOI: 10.1016/j.pec.2014.12.010
PMCID: PMC4404157
PMID: 25636694 [Indexed for MEDLINE]
Author information:
(1)Pediatric MS and Neuroinflammatory Disorders Program, Division of Neurology,
Department of Pediatrics, Neuroscience and Mental Health, Hospital for Sick
Children Research Institute, Hospital for Sick Children, 555 University Avenue,
Rm 6D33, Toronto, ON, M5G1X8, Canada. ann.yeh@sickkids.ca.
(2)Faculty of Medicine, The University of Toronto, 1 King's College Circle #3172,
Toronto, ON, M5S 1A8, Canada. ann.yeh@sickkids.ca.
(3)Pediatric MS and Neuroinflammatory Disorders Program, Division of Neurology,
Department of Pediatrics, Neuroscience and Mental Health, Hospital for Sick
Children Research Institute, Hospital for Sick Children, 555 University Avenue,
Rm 6D33, Toronto, ON, M5G1X8, Canada.
(4)DeltaQuest Foundation Inc., 31 Mitchell Road, Concord, MA, 01742, USA.
(5)Children's Hospital of Pittsburgh, University of Pittsburgh School of
Medicine, 4401 Penn Avenue, Pittsburgh, PA, 15224, USA.
(6)Division of Neurology, Children's Hospital of Philadelphia, 3401 Civic Center
Blvd., Philadelphia, PA, 19104, USA.
(7)Department of Psychiatry, The Hospital for Sick Children, 555 University
Avenue, Toronto, ON, M5G1X8, Canada.
(8)Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue,
Boston, MA, 02115, USA.
(9)University of California San Francisco, 505 Parnassus Avenue, San Francisco,
CA, 94143, USA.
(10)Texas Children's Hospital, Baylor College of Medicine, 6621 Fannin Street,
Houston, TX, 77030, USA.
(11)Alberta Children's Hospital, 2888 Shanganappi Trail NW, Calgary, AB, T3B 6A8,
Canada.
(12)University of Alabama at Birmingham, 1720 2nd Avenue, Birmingham, AL, 35294,
USA.
(13)ELLICSR: Health, Wellness, and Cancer Survivorship Centre, University Health
Network, 585 University Avenue, Toronto, ON, M5G 2C4, Canada.
(14)Department of Psychology, Faculty of Medicine, University of Toronto, 1
King's College Circle #3172, Toronto, ON, M5S 1A8, Canada.
(15)Departments of Medicine and Orthopaedic Surgery, Tufts University Medical
School, 800 Washington Street, Boston, MA, 02111, USA.
Erratum in
Qual Life Res. 2017 Dec 23;:.
DOI: 10.1007/s11136-017-1571-z
PMCID: PMC6149210
PMID: 28393317 [Indexed for MEDLINE]
Author information:
(1)Department of Internal Medicine, Endocrinology, Diabetes & Metabolism Unit,
Ladoke Akintola University of Technology, & LAUTECH Teaching Hospital, Ogbomoso,
Oyo State, Nigeria.
(2)Department of Medicine, General Hospital Odan, Lagos Nigeria.
(3)Department of Medicine, BOWEN University & BOWEN University Teaching Hospital,
Ogbomoso.
DOI: 10.4314/ahs.v18i4.3
PMCID: PMC6354893
PMID: 30766548 [Indexed for MEDLINE]
Author information:
(1)School of Health Policy & Management, Nanjing Medical University, 211166
Nanjing, China.
(2)Creative Health Policy Research Group, Nanjing Medical University, 211166
Nanjing, China.
(3)School of Health Economics and Management, Nanjing University of Chinese
Medicine, 210023 Nanjing, China.
DOI: 10.1155/2018/1471808
PMCID: PMC6327275
PMID: 30687763
Author information:
(1)Pharmacy Department, Federal University of Parana , Curitiba; & Pharmaceutical
Sciences Department, State University of Ponta Grossa, Ponta Grossa, PR ( Brazil
). gerusach@hotmail.com.
(2)Pharmacy Department, Federal University of Parana , Curitiba, PR ( Brazil ).
edsonhipolitojr@gmail.com.
(3)Pharmacy Department, Federal University of Parana , Curitiba; & Pharmaceutical
Sciences Department, State University of Ponta Grossa, Ponta Grossa, PR ( Brazil
). michelotuki@yahoo.com.br.
(4)Pharmacy Department, Federal University of Parana , Curitiba, PR ( Brazil ).
cassyano.correr@gmail.com.
DOI: 10.18549/PharmPract.2015.04.597
PMCID: PMC4696117
PMID: 26759614
1975. Patient Prefer Adherence. 2017 Mar 28;11:661-669. doi: 10.2147/PPA.S121032.
eCollection 2017.
Bolge SC(1), Eldridge HM(2), Lofland JH(3), Ravin C(3), Hart PJ(4), Ingham MP(1).
Author information:
(1)Health Economics and Outcomes Research, Janssen Scientific Affairs, LLC,
Raritan.
(2)Payer Provider Insights & Analytics, Janssen Services, LLC, Titusville, NJ.
(3)Health Economics and Outcomes Research, Janssen Scientific Affairs, LLC,
Horsham, PA.
(4)Value Communications, Medaxial Group, New York, NY, USA.
OBJECTIVE: The objective of this study was to describe patient experience with
intravenous (IV) biologics for ankylosing spondylitis, Crohn's disease, psoriatic
arthritis, psoriasis, rheumatoid arthritis, or ulcerative colitis.
METHODS: Semi-structured telephone interviews were conducted in 405 patients with
these autoimmune diseases who were receiving an IV biologic to treat their
disease.
RESULTS: On a 7-point scale (1= not at all satisfied; 7= very satisfied), mean
satisfaction with IV medication was rated 6.1; 77% of patients rated satisfaction
as 6 or 7. The most frequently perceived benefits of IV therapy were related to
supervision provided by health care professionals. Most patients (82%, n=332)
preferred their IV medication to subcutaneous injection. The three most common
reasons for preferring IV were not wanting to self-inject (43%), less frequent
dosing (34%), and preference for administration by a health care professional
(24%). African-American/black patients had a stronger preference for IV
administration than Caucasian/white patients (97% vs 80%, P<0.05) and a greater
dislike of needles/self-injection (71% vs 40%, P<0.05). Hospital outpatient
departments were not rated as well as physician in-office infusion. Only half
(49%) of the patients reported that both they and their physician equally
influenced the choice to switch from subcutaneous to IV therapy, and only 30%
were given a choice of infusion center.
CONCLUSION: Users of IV biologics are highly satisfied with their medications and
perceive the opportunity for health care provider interaction at their infusion
facilities as an advantage of their regimen. These findings support continued
need for IV therapeutic options and shared decision-making between patients and
physicians while selecting biologic treatments.
DOI: 10.2147/PPA.S121032
PMCID: PMC5378465
PMID: 28405158
Kaldo V(1), Jernelöv S(2), Blom K(3), Ljótsson B(4), Brodin M(3), Jörgensen M(3),
Kraepelien M(3), Rück C(3), Lindefors N(3).
Author information:
(1)Karolinska Institutet, Department of Clinical Neuroscience, Division of
Psychiatry, Stockholm, Sweden. Electronic address: viktor.kaldo@ki.se.
(2)Karolinska Institutet, Department of Clinical Neuroscience, Section of
Psychology, Stockholm, Sweden.
(3)Karolinska Institutet, Department of Clinical Neuroscience, Division of
Psychiatry, Stockholm, Sweden.
(4)Karolinska Institutet, Department of Clinical Neuroscience, Division of
Psychiatry, Stockholm, Sweden; Karolinska Institutet, Department of Clinical
Neuroscience, Section of Psychology, Stockholm, Sweden.
Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.brat.2015.06.001
PMID: 26091917 [Indexed for MEDLINE]
Author information:
(1)Department of Personality Psychiatry, Clinic of Mental Health and Addiction,
Oslo University Hospital, Oslo, Norway.
© 2014 The Authors. Psychology and Psychotherapy published by John Wiley & Sons
Ltd on behalf of the British Psychological Society.
DOI: 10.1111/papt.12036
PMCID: PMC4344810
PMID: 25045028 [Indexed for MEDLINE]
1978. BMC Med Inform Decis Mak. 2015 Jun 18;15:46. doi: 10.1186/s12911-015-0171-5.
Hardinge M(1), Rutter H(2), Velardo C(3), Shah SA(4), Williams V(5), Tarassenko
L(4), Farmer A(5).
Author information:
(1)Oxford University Hospitals NHS Trust, Oxford, UK.
(2)Oxford Health Foundation Trust, Oxford, UK.
(3)Department of Engineering Science, University of Oxford, Oxford, UK.
carmelo.velardo@eng.ox.ac.uk.
(4)Department of Engineering Science, University of Oxford, Oxford, UK.
(5)Nuffield Department of Primary Care Health Sciences, University of Oxford,
Oxford, UK.
DOI: 10.1186/s12911-015-0171-5
PMCID: PMC4472616
PMID: 26084626 [Indexed for MEDLINE]
Lindell VA(1), Stencel NL(1), Ives RC(1), Ward KM(1), Fluent T(1), Choe HM(1),
Bostwick JR(1).
Author information:
(1)Lindell, PharmD, BCACP, Clinical Ambulatory Pharmacist, Michigan Medicine, Ann
Arbor, MI. Stencel, PharmD Candidate 2018, Pharmacy Student, University of
Michigan College of Ph