Multiple Choice Questions (Unit 1 & 2)

1. Amorphous form of drug dissolves---------- than the crystalline form.

a) Slower c) faster
b) Equal to d) does not dissolve
2. The maximum amount temperature at which two phase region exists in a mixture of two partially
miscible liquid is known as:
a) Upper consolute temperature
b) Lower consolute temperature
c) Critical temperature
d) Kraft point
3. When solid changes to gas is called:
a) Melting c) condensation
b) Sublimation d) vaporization
4. Surface tension of liquid------ with increase in temperature:
a) Decrease c) no change
b) Increase d) none of the above
5. Pressure required to bring about liquefaction at critical temperature is called
a) Vapor pressure c) Critical pressure
b) Atmospheric pressure d) Partial pressure
6. Ability of a drug substance to exist in more than one crystalline form is known as:
a) Polymorphism c) Fusion
b) Polycrystallinity d) Crystallinity
7. Which of the following states that the pressure of as fixed amount of gas at constant temperature is
inversely proportion to volume of gas?
a) Charle’s law c) Avagadro’s law
b) Boyle’s law d) Gay-lussac’s law
8. Which of the following is known as supercooled liquids
a) Amorphous solid c) Molecular solids
b) Ionic solid d) crystalline solid
9. Mesomorphic substances:
a) Are in between solids and liquid c) are smectic
b) Have different properties in different direction d)are nematic
10. How does vapor pressure react to increased temperature?
a) Vapor pressure is decreased c) vapor pressure is increased
b) First it decreases and then increases d) no change
11. Which of the following properties are not shared by crystalline solids and amorphous solids?
a) Definite shape c) definite volume
b) Incompressibility d) definite melting point
12. What kind of liquid crystal consists of parallel molecules in layers?
a) Cholestric c) nematic
b) Smectic d) all of the above
13. One of the assumptions of ideal gas law is that:
a) molecules have no attraction to one another
b) Gas particles move very slowly
c) Molecule move in curved path
d) None of the above
14. A vapor is:
a) A very dense gas
b) A gas with weak vander waal’s force
c) A gas that is normally a liquid
d) A liquid that is normally a gas.
15. Which of the following are properties of amorphous solids?
a) No crystal structure c) No definite melting point
c) Glassy d) All of the above

16. Dielectric constant of a solvent is a measure of:

a) Ionization c) polarity
b) Conductivity d) viscosity
16. Velocity of light is maximum in:
a) Diamond c) water
b) Vacuum d) glass
17. Practically value of dielectric constant of air is:
a) 1 b) 0 c) more than 1 d) less than 1
18. Which of the following refractometer is used for determination of refractive index:
a) Abbe’s c) Pulfrich
b) V block d) all of the above
19. Point at which all the three phases are in equilibrium:
a) Triple point b) critical point
b) Double point d) eutectic point
20. Specific rotation is useful in:
a) Determination of purity of compound
b) Determining optical rotation
c) Determining the strength
d) Determining polarity
21. Refractive index is used to:
a) Measure the concentration of solute in aquos solution
b) Calculate focal power of lenses and dispersive power of prism
c) Estimation of thermophysical properties of hydrocarbon
d) All of the above
22. Ionic polarization is due to:
a) External magnetic field
b) Dissociation of ions
 c) Displacement of cations and anions
d) None of the above
23. The relationship between pH, pKa and extent of ionization is described by:
a) Fick’s law
b) Noyes- whitney equation
c) Michaelis- Menten equation
d) Henderson- Hasselbalch equation
24. The substance which rotates plane of polarized light towards left or in anti clockwise direction are
called:
a) Laevorotatory
b) Dextrorotatory
c) Conformation’
d) Rotation
25. Refractive index is:
a) n= c/v b) n=v/c
b) n=c*v d) n= c/v*c
26. Fick’s law is used to study:
a) Dissolution rate c) disintegration rate
b) Dissociation rate d) diffusion rate
27. Diffusion is measured by:
a) Franz cell c) paddle apparatus
b) Voltmeter d) rotating basket apparatus
28. The mass transfer of molecules in substance from higher concentration to lower:
a) Diffusion c) dissolution
b) Osmosis d) active transport
29. When the drug release from a dosage from satisfies the Higuchi’s equation, the relase is considered
as:
a) Dissolution rate controlled
b) Diffusion rate controlled
c) absorption rate controlled
d) dissolution and diffusion rate controlled
30. Which equation is used to represent drug dissolution from a tablet?
a) Fick’s law c) Noyes- whitney equation
c) Michaelis- Menten equation d) Henderson- Hasselbalch equation
31. According to Noyes- whitney’s equation, the rate(dc/dt) is expressed as:
a) DS(C2+C1)
b) KS(dx/dt)
c) KS(Cs-C)
d) Ks(Cs/C)
32. ------ is the ratio of mean residence time to absorption time
a) Absorption number
b) Dissolution number
 c) Dose number
d) Intrinsic dissolution
33. Solubility curve is a curve drawn between :
a) Solubility and temperature
b) Solubility and pressure
c) Solubility and mole fraction
d) Temperature and molefraction
34. When non polar substances are dissolved in polar solvent using surfactant, the process is:
a) HLB b) solubilization c) emulsification d) dissolution
35. Solubility of most gases---- with increase in temperature:
a) Increases c) decreases c) does not change
36. The Hansen parameter consists of:
a) Dispersion force component b) hydrogen bond component
b) Dipole-dipole component d) All of the above
37. The solubility of drug will be high when it is in its:
a) Stable form b) Metastable form c) unstable form
38. The solutions which do not obey Raoult’s law are:
a) Ideal solution b) Real solution c) Binary solution d) super saturated solution
39. According to USP, for ’Soluble’, how much parts of solvent is required:
a) 30-100 b) 100-1000 c) 10-30 d) 1-10
40. Which method is used for separating a solution of two immiscible liquids?
a) Simple distillation c) Fractional distillation
b) Decantation d) Extraction