DAFTAR ISI

KATA PENGANTAR ................................................................................................... i

DAFTAR ISI................................................................................................................. ii
DAFTAR GAMBAR ................................................................................................... iii
BAB I. PENDAHULUAN ...........................................................................................1
BAB II. TINJAUAN PUSTAKA ...............................................................................3
2.1. Angiogenesis pada keganasan ginekologi .............................................................3
2.2 Mekanisme antiangiogenesis pada keganasan ginekologi ....................................6
2.3 Terapi antiangiogeik pada keganasan ginekologi .................................................8
2.3.1 Kanker Endometrium ..........................................................................................8
2.3.2 Kanker Ovarium ...............................................................................................10
2.3.3 Kanker serviks .................................................................................................13
2.4 Efek samping terapi antiangiogenik ....................................................................14
2.4.1 Kardiovaskular ..................................................................................................14
2.4.2 Gangguan penyembuhan luka / perforasi gastrointestinal ..................................16
2.4.3 Ginjal..................................................................................................................16
2.4.4 Dermatologi ......................................................................................................17
2.5 Respon tumor terapi antiangiogenik .....................................................................17
BAB III KESIMPULAN............................................................................................20
DAFTAR PUSTAKA .................................................................................................21

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 DAFTAR TABEL

Tabel 1 Karakteristik demografi subyek penelitian .....................................................18

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 DAFTAR GAMBAR

Gambar 1 Keseimbangan angiogenik ............................................................................3

Gambar 2 angiogenik switch klasik ...............................................................................5
Gambar 3 Jalur multiple untuk investigasi pengobatan keganasan ginekologi ............8
Gambar 2.6 Kerangka teori ..........................................................................................33
Gambar 2.7 Kerangka konsep ......................................................................................34

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 DAFTAR SINGKATAN

TIBC : Total Iron Binding Caacity

Hb : Hemoglobin
MCV : Mean Corpuscular Volume
MCH : Mean Corpuscular Hemoglobin
MCHC : Mean Corpuscular Hemoglobin Concentration
NTD : Neural Tube Defect
PHA : Pitohemaglutinin
ConA : Konkanavalin A
KEK : Kekurangan Energi Kronis
Lila : Lingkar lengan atas
IMT : Indeks massa tubuh
HPHT : Hari pertama haid terakhir
RIA : Radioimmunoassay

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