CV for internal transfer, for relocation to AbbVie Worcester, MA, USA

Nipun Mahajan
Email: Nipun.Mahajan@abbvie.com

PROFILE: Currently working as a Technical Operations Analytical Scientist in AbbVie Sligo, I have
actively supported the method transfers of ABT-494, ABT-530, and Rova-T, with ABT-263 in progress. My job
includes providing technical support for a time, cost and safety efficient transfers/improvements to different
departments for New Products.

Having an academic background in bioassay development and separation sciences, I am interested to move to
AbbVie, USA, that can offer scientifically a more challenging environment that is important to learn and to grow.
I feel more inspired by taking responsibilities that can make a difference in AbbVie Business, in our patient’s life
and in the pharmaceutical world.

EDUCATION
Qualification Field of study Institute Month/Year
PhD Analytical Chemistry NUI Galway, Ireland 03/2017
M. Pharmacy Medicinal Chemistry ISF College of Pharmacy, India 09/2009
B. Pharmacy Pharmaceutical Sciences ISF College of Pharmacy, India 05/2007

EXPERIENCE

AbbVie, Sligo Technical Operations Analytical Scientist Jul 2017- Present

➢ NPI Analytical Support: did mainly for ABT-494, ABT-530 and Rova-T; ABT-263 is in progress:
Ensuring timely completion of all testing procedures, method transfers, and lab investigations, writing SOPs
for sampling, sample handling and sample transport in accordance with EHS/Warehouse/QC and
manufacturing requirements, Development of time effective HPLC/UPLC based analytical test methods,
Drafted Local Area Specifications (LAS), Raw Material Specifications (RMS), In-process control and
Finished Product specifications/ procedures for New Product Introduction from S&T site to commercial site

➢ Technical support and Management of NPI transfers: Organising regular meetings with R&D and
S&T teams and with the in-house process and sub-analytical teams for timely achievement of process and
analytical methods transfers, Execution and constructive challenges to the new analytical methods for time
and cost reduction and safety improvements, coordination with QC lab supervisor/QC Lab manager on
method transfers ensuring GLP requirements are met, Learning new methods and providing training to
fellow sub- analytical team, coordination with QA team in approval of supplier, calculation of quantities
support to warehouse team preparing for the worst-case scenario, raising the timely purchase orders for
laboratory needs, supporting the QC team in material testing/document verifications for timely release of
raw material/finished product, in the purchase of the new equipment such as new balances/HPLC/KF and
support in their installation and operational qualification, performing vendor hosting and providing
training/support to the vendors, as needed

➢ Paricalcitol manufacturing and Rova-T Purification support as Process Chemist: Providing

technical support to all small-scale manufacturing/Purification in the chemical synthesis of 4S and 3S API
compounds with 30-80 g amount, raising positive interventions for maintaining the GMP standards in the
CNC area, extensive experience of working in the Glovebox, and handling toxic molecule, developed
 innovative approaches for valuable cost and time reduction working with the engineering department for a
change in the design of the facilities

➢ Process Engineering: Providing continuous technical support to the manufacturing team on the process
design, chemical compatibilities based on the material of constructions, equipment suitability, possible
process controls/hold times, providing training on sampling, writing documentation on cleaning strategy, Pre-
MIR, manufacturing instructions records (MIR), cleaning instructions records (CIR), supporting the Failure
Mode Effect Analysis (FMEA) to QA process, with priority to safety and quality of the product preventing
cross-contamination, supporting the EHS department in performing the Industrial Health monitoring (IH),
support for risk assessment of new equipment installed and in the Process Hazard Assessment (PHA) and
taking necessary actions as assigned in Enviromanager

➢ Validation support: Providing support to the validation team toward the new equipment to be installed for
NPI activities, support in drafting and Pre-approval/post-approval of documentation, User Specific
requirements (USR), System Design Specifications (SDS), Critical components Impact Analysis (CLIA),
review of Installation Qualification, Operational Qualification, Preventative Maintenance (IQ/OQ/PM), setting
equipment

➢ Isotrain - training co-ordinator of Tech Ops: Admin access to Isotrain- Creation, and revision of
Course/Modules/Curriculum, Assignment/Un-assignment of training to Employees, Reconciliation of past
due training, Making employee training reports/training plans ready for internal and external audits

➢ Attache Pro, Trackwise, Enviromanager, LIMS: Experienced with AbbVie day to day used tools

NUI, Galway Hardiman PhD Scholar Jan 2013- Mar 2017

➢ Complex chemical investigations -Discovered ten new natural products from Irish marine territory
➢ Designing and performing analytical tests- by HPLC-DAD-ELSD, UPLC-ELSD-MS, NMR
➢ HPLC method development & validation - Normal→Reverse, Manual→Robotic, Analytical→Preparative,
Columns used such as C18, C8, Phenylhexyl, Cyano, HILIC
➢ Analytical testing- UV-Vis, FT-IR, Polarimetry, titrations, pH, Conductivity testing
➢ Equipment Maintenance and troubleshooting - Agilent 1290, 1260, Waters-alliance-EMPOWER, Jasco
4000, Dionex 3000, Shimadzu prominence preparative HPLC
➢ Technical Project management with timely execution - completed 4 years PhD project in 3.8 years
➢ Excellent communication skills - received best poster award in a scientific conference at TCD, Ireland
➢ Technical and scientific writing - 14 scientific publications, book chapter, PhD thesis & research blog
➢ Public speaking - Oral & poster presentations at 4 National & 3 International scientific conferences
➢ Teamwork – As an analyst with synthetic chemists, microbiologists, biochemists and admin staff

LPU, India Lecturer and Assistant Professor Jan 2013- Mar 2017

➢ Adaptable & Support - Supervised four postgraduate & eight undergraduates’ students
➢ Auditing- Corrections of reports, Exam papers, providing feedback and taking necessary actions
➢ Subject Matter Expert - Qualified GPAT-2010, 28th National rank in Pharmacy Talent Search
➢ Attention to detail - Advised students from designing research, planning, execution to completion
➢ Demonstrating the chemistry and analytical experiments to students

ADDITIONAL INFORMATION
Details of selected publications, conferences attended, additional training courses and Internships and research
skills are mentioned in Annexure I

Training/Internships/Volunteering

2013-2016 (3 years) Teaching Assistant (School of Chemistry), NUI Galway, Ireland

2014-2015 (2 years) President, IndiaSoc (Volunteering), NUI Galway, Ireland
04-2015 (2 days) Science@Sea, on Celtic Voyager, Cork, Ireland
06-2014 (14 days) Sailed on Celtic Explorer - for deep sea sampling, Atlantic Irish Waters
11-2008 (5 months) Research training on natural products, IIIM, CSIR Lab, India
06-2006 (45 days) Industrial training in pharmaceutical manufacturing, SunPharma, HP, India
06-2005 (45 days) Industrial training in analytical testing, DPL, Moga, India

Honors/Achievements

2013-2017 James Hardiman Doctoral Research Fellowship, NUI Galway

2016 Best poster award at 1st Medicinal Chemistry meeting held in TCD, Ireland
2016 Received MI, Oranmore Networking & Travel Grant for XV MaNaPro, Brazil
2016 Received Presidential ALIVE certificate award for excellent leadership
2015 Best International Society award for IndiaSoc under my presidency
2015 Received MI, Oranmore Networking & Travel Grant to attend 9th ECMNP, UK
2010 GPAT 2010-Qualified hosted by MSU of Baroda, India for PhD studies
2008 Third prize in debate competition during pharmacy week at ISFCP, India
2007 GATE 2007-Qualified exam hosted by IIT Kanpur, India for MHRD funding
2007 Received 28th Rank all India in Senior-level, Pharmacy Talent Search Exam
2007-2009 Received MHRD scholarship from Government of India for M. Pharmacy
2006 First prize in poster presentation during pharmacy week ISFCP, India

Unique Skill Set

Drug discovery HPLC, NMR & bioassay-guided isolation and purification of natural
products from plants, lichens, marine microbes & marine invertebrates
Chemical synthesis Retrosynthesis, C-C bond formation, derivatization for SAR and Hit-to-lead
optimization, wet chemistry, scaling up methods
Separation Science Highly skilled in Solid Phase Extraction, Vacuum Liquid Chromatography,
UPLC & HPLC ( Agilent 1290, Agilent 1260, Dionex Ultimate 3000, Waters
Alliance, Jasco) analytical to preparative scale, normal to reverse phase
Structure elucidation Characterization of molecules using spectroscopic data including ECD, UV,
IR, 1D, 2D NMR and MS analysis and chemical synthesis

Cell biology Isolation of RNA, DNA and proteins, Nanodrop, RT-PCR & ELISA, Staining,
Confocal and fluorescent microscopy, Cell lines used: Mesenchymal Stem
cells, MOLM-13 (Leukemic), HS-5 (Fibroblast), Primary mononuclear cells
In vitro Bioassays In vitro: Chrondrogenesis (3D cell culture), osteogenesis (Ca2+ deposition),
cytotoxicity assay (Alamar blue and MTT), Antimicrobial assay (disk
diffusion), antioxidant assay (ABTS and DPPH)
In vivo Bioassays In vivo: muscle relaxant activity (rotarod), analgesic effects (tail-flick and
hot plate) anti-inflammatory activity (carrageenan-induced paw oedema),
worked with isolated preparations (frog-rectus abdomens and rat-ileum)
Microbiology Isolation, culturing, cryopreservation of marine microbes, fermentation
scaling up, epigenetic modification, building microbial isolates library with
their database
 Software Empower, OpenLab, ChromNav, Chemdraw, MNova, MassHunter,
Scifinder, MarinLit, EndNote, Latex, Prezi, MS Office (Word, PowerPoint)

Conferences attended/Presentations

Talk “Treasure from the Atlantic Ocean” in Threesis competition at NUI Galway on
(Winner) Nov. 2nd, 2016 – Second position in the regional level
Talk “Chemical treasure from Irish Waters” in the final event of Beaufort Marine
Biodiscovery awards at Marine Institute, Galway on Jun 30th, 2016

Talk “Novel immunomodulatory scaffolds from Irish lichen Lichina Pygmaea” at XV

(International) MaNaPro conference held in Ceara, Brazil on Aug 29th, 2016

Poster “Building Irish-Marine Natural Products Library (I-MNPs) for pharmaceutical

(Winner) applications” at 1st Medicinal Chemistry Ireland Meeting held in Trinity
Biomedical Science Institute, Trinity College Dublin, on July 1st, 2016

Poster “Towards the search of novel bioactive molecules from North Atlantic Ocean”
(International) at 9th European Conference on Marine Natural Products held in Glasgow,
Scotland from Aug. 30th till Sep. 2nd 2015

Poster “Evaluation of Irish Marine Organisms against Osteoarthritis” at 5 th Beaufort

(International) Annual Researchers Meeting held in Queen’s University Belfast, on Dec. 15th
and 16th, 2015

Poster “Towards the discovery of Marine Natural Products as Anti-Osteoarthritis

molecules” at 4th Beaufort Annual Researchers Meeting in NUI, Galway on
Jan. 15th and 16th, 2014

Poster “Self-medication: a challenge for drug discovery and development” at a

National Seminar held Jamia Hamdard University, New Delhi, India, on Sep.
17th & 18th, 2011

Participant Attended conference “Nano-colloidal carrier: site-specific and controlled drug

delivery” held at ISFCP, Moga, India on Oct. 10th &11th, 2008

Contributions to Science

Pygmanilines are new natural products that were discovered from Irish marine Lichen Lichina pygmaea
after screening 864 marine extracts. Pygmanilines are small, UV-absorbent molecules that are non-
toxic to primary monocytes and can be synthesized in a single step straight forward reaction with more
than 90% yield. Pygmanilines holds the commercial potential to be developed as sunscreen products
and are currently under investigations to find applications for UV-induced skin cancer. In addition, I
have discovered ten new natural products from Irish marine organisms, supervised four Master and
eight undergraduate research projects to completion, co-authored one book chapter, 13+ publications,
presented my research work at four national and three international conferences. Also, I have
communicated science to the general public audience through Threesis and FameLab competitions,
research blogs & scientific research videos that are publicly accessible.
 Bibliography

Book Firsova, D., Mahajan, N., Solanki, H., Morrow, C., & Thomas, O. P. 2016 Current Status
Chapter and Perspectives in Marine Biodiscovery In: Peterson R.M, Bioprospecting - successes,
potential and constraints. Springer ed http://dx.doi.org/10.1007/978-3-319-47935-4_3
13 Accepted manuscript (MS. No. NPC2017AFB6) Mahajan, N., Calabro, K., Morrow, C. &
Thomas, O. P. “N-Didehydrotyrosine identified from the Northeastern Atlantic marine sponge
Hymeniacidon perlevis after Chemical Screening” Nat. Prod. Comm.
https://doi.org/10.1177/1934578X1701200628
12 Mahajan, N., Chadda, R., Calabro, K., Solanki, H., O'Connell, E., Murphy, P. V., &
Thomas, O. P. 2017 “Isolation and synthesis of pygmanilines, phenylurea derivatives
from the Northeastern Atlantic lichen Lichinia Pygmaea” Tet. Lett., 58 (12), pp. 1237-
1239 http://dx.doi.org/10.1016/j.tetlet.2017.02.037
11 Angulo-Preckler, C., Genta-Jouve, G., Mahajan, N., de la Cruz, M., de Pedro, N.,
Reyes, F., Iken, K., Avila, C. and Thomas, O.P., 2016 “Gersemiols A–C and Eunicellol
A, Diterpenoids from the Arctic Soft Coral Gersemia fruticosa” J. Nat. Prod. 79(4),
pp.1132-1136 http://dx.doi.org/10.1021/acs.jnatprod.6b00040
10 Aditi, Mahajan, N., Rawal S., Katare R., 2013 “An Insight into the Pathogenesis of
Diabetic Vascular Diseases: Role of Oxidative Stress and Antioxidants” Pharm Anal
Acta 4(10):273 http://dx.doi.org/10.4172/2153-2435.1000273
9 Mahajan, N., Rawal, S., Verma, M., Poddar, M. and Alok, S., 2013 “A
phytopharmacological overview on Ocimum species with special emphasis on Ocimum
sanctum” Bio. & Prev. Nut., 3(2), pp.185-192,
http://dx.doi/org/10.1016/j.bionut.2012.08.002
8 Sarika, D., Monica, S., Anu, M., Shruti, R., Pathak, D.P., and Mahajan N., 2012 “A rapid
densitometric method for the quantification of apigenin-7-glucoside in Euphorbia
prostrata herb using HPTLC” JPR, 5 (2), pp. 859-861
http://jprsolutions.info/newfiles/journal-file-56ab18ea28f159.03466944.pdf
7 Sharma, P., Mahajan N., Pankaj, G., Gurukirpal, S., Sumit, D. and Sakshi, S., Malaxis
acuminata: A review. IJRAP 2(2) pp. 422-425
http://www.ijrap.net/admin/php/uploads/434_pdf.pdf
6 Thakur, A., Gill, H.K., Sharma, A., Mahajan, N. and Rawal, S., 2011. Pharmacy and
Pregnancy: A Review. IJPSR, 2(8), pp.1997-2009,
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(8).1997-09
5 Mahajan, N., Dhar, K.L., Suri, O.P., Nepali, K., Kamra, N., Garg, A. Sharma, A., 2010
“Synthesis of some N-heterocyclic analogs of vasicine” IJPSR, 1(2), pp.78-87,
http://dx.doi.org/10.13040/IJPSR.0975-8232.1(2).78-87
4 Mahajan A., Rawal S., Bedi PMS., Mahajan N., Sharma A., 2010 Aromatase Inhibitors:
A New Hope for Breast Cancer Patients. IJPSR, 1(6), pp 27-40
http://dx.doi.org/10.13040/IJPSR.0975-8232.1(6).27-40
3 Rawal S., Sood R., Mahajan N., Sharma M., Sharma A., 2010 Current status and future
prospects for Tuberculosis. IJPSR, 1(5), pp 128-134
http://dx.doi.org/10.13040/IJPSR.0975-8232.1(5).128-34
2 Rawal S., Shashi A., Mahajan N., Mahor A., Joshi A., and Sharma P., 2010 Diabetic
neuropathy: Still a challenge in Pharmacology. IJPSR, 1(1), pp 12-27
http://dx.doi.org/10.13040/IJPSR.0975-8232.1(1).12-28
1 Sen, K., Goel, A., Rawal, S., Mahajan, N., Baboo, S. and Alok, S., 2010 Antimicrobial
activity of Basella rubra leaves. IJPSR, 1(2), pp.88-91,
http://dx.doi.org/10.13040/IJPSR.0975-8232.1(2).88-91