Aims of Education
1. To provide professional training
for development of new Inter-
biomaterials and biotechnology disciplinary
Education
2. To develop boundary-crossing
ideas and techniques in Biology
field
Active
3. To build students’ own Collaborations
interdisciplinary pathway Between labs Development of
(industry, academia, and start- innovative
biomaterials and
ups) biotechnology
4. To maximize collaboration of
labs in different disciplines
Special Topics in GIBBS Convergence Seminar Ⅳ Understanding New Drug Translational Research I
Aging and Reactive Oxygen Radical(ROS) Novel Drug Development for Anti-aging
Areas of Expertise
1) Anti-Cancer Drug, Cancer Stem Cell, Tumor Mouse Model, Drug-Repositioning
2) Pharmabiotic, Color-Food Fermentation using Probiotics, Bio-Conversion,
Research Focus
1. Development of Anti-Cancer Drug using Drug-Repositioning and Pharmabiotic
2. Pharmabiotic Study using Probiotics and Color Food
3. Drug Development against Cancer Stem Cells
4. Immuno Chemotheraphy through NK Cell and Microenviroment
Inhibitor of Drug-Repositioning
Cancer Stem Cell
Selected publications
1. The PAK1-Stat3 Signaling Pathway Activate IL-6 Gene and Human Breast Cancer Stem
Cells Formation. Cancers. 2019 (in press)
2. Disruption of the NF-κB/IL-8 Signaling Axis by Sulconazole Inhibits Human Breast Cancer
Stem Cell Formation. Cells. 2019 Aug 30; 8(9): 1007
3. Dihydrotanshinone-induced NOX5 Activation Inhibits Breast Cancer Stem Cell through the
ROS/Stat3 Signaling Pathway. Oxid Med Cell Longev. 2019 Mar 24; 2019 doi:
10.1155/2019/9296439
4. Catechol derived from aronia juice through lactic acid bacteria fermentation inhibits breast
cancer stem cell formation via modulation Stat3/IL-6 signaling pathway. Molecular
Carcinogenesis, 2018 Jul 2; 57(11): 1467-1479
5. Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes. Nature
2008 Sep 18; 455(7211): 363-368
Somi Kim Cho
Ph.D.
Areas of Expertise
Biochemistry, Cell biology, Food Science & Biotechnology, Molecular Biology, Phytochemistry
Research Focus
Characterization of drug-resistant and radiation-
Screening and resistant cancer cell lines by transcriptome analysis
Identification Screening and identification of high value-added
biomaterials for drug-resistant and radiation-
resistant cancer cell lines
Mechanism studies on resistance to Chemo- and
Mechanism Radiotherapy
studies Anti-cancer mechanism of individual compounds
using various bioassays
Validation of anti-cancer activity of new candidates
In-vivo in in-vivo mouse models
animal model
studies Exploration and optimization of methods to increase
bioavailability of new candidates
Selected publications
1. Baicalein Suppresses Stem Cell-Like Characteristics in Radio- and Chemoresistant MDA-MB-
231 Human Breast Cancer Cells through Up-Regulation of IFIT2. Nutrients. 2019, 11, 624
2. Nootkatone, an AMPK activator derived from grapefruit, inhibits KRAS downstream
pathway and sensitizes non-small-cell lung cancer A549 cells to adriamycin. Phytomedicine.
2019, 63. 153000
3. Nobiletin Enhances Chemosensitivity to Adriamycin through Modulation of the
Akt/GSK3β/β–Catenin/MYCN/MRP1 Signaling Pathway in A549 Human Non-Small-Cell Lung
Cancer Cells. Nutrients. 2018, 10, 1829
4. Inhibitory Effect of Zinc Sulfide Nanoparticles Towards Breast Cancer Stem Cell Migration
and Invasion. Journal of Biomedical Nanotechnology. 2016, 12(2);329-336
5. β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through
down-modulation of NF-κ-regulated gene products. APOPTOSIS. 19(19), 708-7185.
6. Ginsenoside F2 induces apoptosis accompanied by protective autophagy in breast cancer
stem cells. Cancer Letters. 321(2), 144-153.
Youngheun Jee
D.V.M., Ph.D.
Research Focus
1. Immune responses for phytochemicals
2. Therapeutic intervention of organ-specific immune disease
3. Immune mechanisms of immune disorder
II. gliosis
I. Inflammation Microglia, astrocyte activation
M, Dendritic cells, NK APC (glutamate, etc.)
cells, Granulocytes T
c
e
ll
Th2
III. Immune Regulation Treg
(T-reg and Th17 IV. Immune suppression
induction, Hematopoiesis, Immune
Inflammations) Immune cells cell regeneration
Selected publications
1. IKKβ-mediated inflammatory myeloid cell activation exacerbates experimental
autoimmune encephalomyelitis by potentiating Th1/Th17 cell activation and compromising
blood brain barrier. Mol. Neurodegener. 2016;11(1):54.
2. Lipocalin-2 protein deficiency ameliorates experimental autoimmune encephalomyelitis:
the pathogenic role of lipocalin-2 in the central nervous system and peripheral lymphoid
tissues. J. Biol. Chem. 2014;289(24):16773-89.
3. Peroxisome proliferator-activated receptor γ-mediated suppression of dendritic cell
function prevents the onset of atopic dermatitis in NC/Tnd mice. J. Allergy Clin. Immunol.
2011;127(2): 420-429.e1-6.
4. The classical NFkB pathway is required for phloroglucinol-induced activation of murine
lymphocytes. Biochim. Biophys. Acta. 2010;1800(7): 639-645.
5. Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of
autoimmune myasthenia. J. Immunol. 2005;15;175(12): 7898-904.
Jinu Kim
Ph.D.
Areas of Expertise
Renal Fibrosis, Chronic Kidney Disease, Acute Kidney Injury, Cell Death, Cell Proliferation,
Renal Physiology
Research Focus
1. Ferroptosis among cell death manners is critical for tubular damage after kidney injury.
2. Nerve activation is important role in the development and progression of renal fibrosis.
Selected publications
1. Renal sympathetic nerve activation via alpha2-adrenergic receptors in chronic kidney
disease progression. Kidney Res Clin Pract. 2019 Mar 31;38(1):6-14.
2. Exogenous CGRP upregulates profibrogenic growth factors through PKC/JNK signaling
pathway in kidney proximal tubular cells. Cell Biol Toxicol. 2018 Aug;34(4):251-262.
3. Spermidine rescues proximal tubular cells from oxidative stress and necrosis after
ischemic acute kidney injury. Arch Pharm Res. 2017 Oct;40(10):1197-1208.
4. Poly(ADP-ribose) polymerase regulates glycolytic activity in kidney proximal tubule
epithelial cells. Anat Cell Biol. 2016 Jun;49(2):79-87.
5. Renal denervation prevents long-term sequelae of ischemic renal injury. Kidney Int. 2015
Feb;87(2):350-8.
Moonjae Cho
Ph.D.
Areas of Expertise
Cell and Molecular Biology, Cancer Biology, Glycobiology, Idiopathic pulmonary fibrosis,
wound care management, Gut microbiota analysis
Research Focus
1. Prebiotics and its role in modulating gut microbiota
2. Molecular signaling pathways in idiopathic pulmonary fibrosis and lung cancer
3. Development of bioactive compounds for wound care management
Selected publications
1. A novel synthetic material, BMM, accelerates wound repair by stimulating re-
epithelialization and fibroblast activation. International Journal of Molecular Sciences.
2018;19(4): 1164
2. TMF and glycitin act synergistically on keratinocytes and fibroblasts to promote wound
healing and anti-scarring activity. Experimental & Molecular Medicine 2017;49: 302
3. β-Glucan-Based Wet Dressing for Cutaneous Wound Healing. Advances in Wound Care.
2019;8(4):125-135
4. Effect of mushroom (Schizophyllum spp.) derived β-glucan on low-fiber diet induced gut
dysbiosis. Journal of Applied Biological Chemistry. 2019;62(2): 211-217
5. SIRT-1 regulates TGF-β-induced dermal fibroblast migration via modulation of Cyr61
expression, Connective Tissue Research. 2018;59(3):245-254
6. Activation of NADPH oxidase subunit ncf4 induces ROS-mediated EMT signaling in HeLa
cells. Cellular signaling.2014;26:784-796
Sung-Cherl Jung
Ph.D.
Areas of Expertise
Human Physiology, Electrophysiology, Neurophysiology, Cell physiology, Neuroscience,
Neuropharmacology, Behavioral and Psychiatric Disorders, Neurodegeneration
Research Focus
1. Chemical synapses and neural network
2. Memory function and mechanism
3. Kinetics of cation channels in excitable cells
4. Cellular mechanisms for depressive disorder and ADHD
5. Synaptic dysfunction of neurodegenerative disease
6. ROS signalling of neurons and degeneration
7. Testing neurotoxic agents
8. Ethical review in medical science
Selected publications
1. Activation of ryanodine receptors is required for PKA-mediated downregulation of A-type
K+ channels in rat hippocampal neurons. J Neurosci Res. 2017 Dec;95(12):2469-2482.
2. Neuroprotective mechanisms of dieckol against glutamate toxicity through reactive
oxygen species scavenging and nuclear factor-like 2/heme oxygenase-1 pathway. Korean J
Physiol Pharmacol. 2019 Mar;23(2):121-130.
3. Chronic Ca2+ influx through voltage-dependent Ca2+ channels enhance delayed rectifier
K+ currents via activating Src family tyrosine kinase in rat hippocampal neurons. Korean J
Physiol Pharmacol. 2017 Mar;21(2):259-265.
4. Roles of somatic A-type K(+) channels in the synaptic plasticity of hippocampal neurons.
Neurosci Bull. 2014 Jun;30(3):505-14.
5. I(h) channels prevent overexcitability of early developmental CA1 neurons showing high
input resistance in rats. Brain Res Bull. 2013 Feb;91:14-20.
Hong-Shik Oh
Ph.D.
Areas of Expertise
Ecology, Taxonomy, Animal Behavior, Conservation Biology, Environmental Ecology, Wildlife
Disease, Reproductive Biology, Island biology and biogeography
Research Focus
Selected publications
1. Various branching patterns of the aortic arch in the Siberian roe deer (Capreolus pygargus,
Pallas, 1771) on Jeju Island. Journal of Veterinary Medical Science, 2019; 81(2): 160-164.
2. A study on the analysis of mammals’activity patterns and the effect of human hiker
interference using camera trapping. Journal of Asia-Pacific Biodiversity, 2019; 12(1): 57-62.
3. Genetic identification of prey species from teeth in faeces from the Endangered leopard
cat Prionailurus bengalensis using mitochondrial cytochrome b gene sequence.
MITOCHONDRIAL DNA PART A, 2018; 29(2): 170-174.
4. Genetic identification for prey birds of the Endangered peregrine falcon ( Falco peregrinus).
MITOCHONDRIAL DNA PART A, 2018; 29(2): 175-180.
5. First molecular evidence of Mus musculus bactrianus in Nepal inferred from the
mitochondrial DNA cytochrome B gene sequences. MITOCHONDRIAL DNA PART A, 2018;
29(4): 561-566.
6. Complete mitochondrial genome of the Ussuri white-toothed shrew Crocidura lasiura
(Insectivora, Soricidae). MITOCHONDRIAL DNA, 2016; 28(2): 350-352.
Jeongsik Kim
Ph.D.
Areas of Expertise
Plant senescence, Circadian rhythm, Flowering time, Molecular evolution, Phenomics, NGS,
Gene editing, and Evergreen lawn
Research Focus
1. Plant developmental programs; circadian rhythm, flowering time and plant senescence
2. Genetic programs underlying plant adaptation in habitats
3. Molecular programs responsible for interaction between environment, phenome, and genome
4. Generation of ever-green Korean lawn grasses
Research Focus
1. The role of orphan nuclear receptors on age-related disease
2. The role of RNA binding protein & RNA decay on apoptotic signaling
3. Development of bioactive materials for disease control
4. Development of disease-specific animal model
Selected publications
1. RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat
shock protein 70 family. Nat Commun. 2019 Jan 8;10(1):77.
2. Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-
degrading enzymes. Nat Commun. 2017 Dec 15;8(1):2133
3. Glycoproteins and Polysaccharides are the main Class of Active Constituents Required for
Lymphocyte Stimulation and Antigen-Specific Immune Response Induction by Traditional
Herbal Plants. J Med Food. 2017 Oct;20(10):1011-1021
4. Quercetin inhibits Cr(VI)-induced malignant cell transformation by targeting miR-21-
PDCD4 signaling pathway. Oncotarget. 2017 Sep 16; 8(32): 52118-52131
5. Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic
involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism. Sci Rep. 2016 Nov
23;6:37227..
Eunju Ko
D.V.M., Ph.D.
Areas of Expertise
Immunology, Virus, Vaccine, Adjuvant, Infectious Disease, Dendritic cells, Innate immunity,
Adaptive immunity, Antivirals
Research Focus
1. Development of new viral vaccines
2. Improvement of vaccine efficacy
3. Immune mechanisms of virus and vaccines
4. Age, sex, environment-dependent immune responses to virus and vaccines
Virus
Immune responses and
Viral pathogenesis
interaction between
virus and host
Selected publications
1. Flagellin-expressing virus-like particles exhibit adjuvant effects on promoting IgG isotype-
switched long-lasting antibody induction and protection of influenza vaccines in CD4-
deficient mice. Vaccine. 2019 Jun 6;37(26):3426-3434.
2. Replicating adenovirus-SIV immunization of rhesus macaques induces mucosal dendritic
cell activation and function leading to rectal immune responses. Front Immunol. 12 April
2019; 10:779.
3. MPL and CpG combination adjuvants promote homologous and heterosubtypic cross
protection of inactivated split influenza virus vaccine. Antiviral Res. 2018 Aug; 156:107-115
4. Roles of Aluminum Hydroxide and Monophosphoryl Lipid A Adjuvants in Overcoming
CD4+ T Cell Deficiency To Induce Isotype-Switched IgG Antibody Responses and Protection
by T-Dependent Influenza Vaccine. J Immunol. 2017 Jan 1;198(1):279-291.
5. Effects of MF59 Adjuvant on Induction of Isotype-Switched IgG Antibodies and Protection
after Immunization with T-Dependent Influenza Virus Vaccine in the Absence of CD4+ T
Cells. J Virol. 2016 Jul;90(15):6976-6988.