e338 Abstracts
POSTER SESSION
M
O
N
D Results: In our study the incidence of GH was 35%. PE characterizes 13% of
LATE-BREAKERS POSTER’S SESSION LB03:
A SESSION 3 - POSTER
Y between IC and PE in delivery week (CH 38.5 ± 1.8 vs PE 36.4 ± 1.8,p = 0.008)
P Proceeding through the pregnancy both OBP and 24h-ABPM showed a gradual
O LB.03.01 LONG TERM CARDIAC STRUCTURE CORRELATES
S WITH ADVERSE PERINATAL COMPLICATIONS IN
T YOUNG ADULTS BORN PRETERM
E The average number of drugs at start of pregnancy resulted comparable among
R M. Mian1, J.L. Bigras2, R. Fernandes1, M. Bertagnolli1, L.F. Xie1, K. Paquette2,
R. Wu1, A. Cloutier1, V. Orlando1, T.M. Luu2, A.M. Nuyt2. 1Fetomaternal and
S Neonatal Pathologies Axis, Research Center of Sainte-Justine Hospital, Univer-
sity of Montreal, Montreal, Canada, 2Department of Pediatrics, Sainte-Justine
Hospital and Faculty of Medicine University of Montreal, Montreal, Canada
Objective: Studies support a direct causal association between preterm birth and
increased risk of cardiovascular diseases. Increased left and right ventricular mass
and impaired systolic and diastolic function have been reported in young adults
born preterm. Deleterious neonatal complications associated with preterm birth
could significantly impact myocardial tissue. We assessed cardiac structure and
function in young adults born extremely preterm (EPT) versus term and examined
the impact of neonatal bronchopulmnonary dysplasia (BPD).
Design and method: Eighty-five EPT (gestational age < 29 weeks) were recruit-
ed along with term-born controls matched for age, sex and socio-economic sta-
tus. Birth data including neonatal parameters (gestational age, birth weight, BPD
indicated by 36 weeks postnatal oxygen use) was collected. Ambulatory blood
pressure (Spacelabs) and echocardiographic measurements (Phillips)were taken.
Comparisons were performed using ANOVA or Student’s t-test.
Results: EPT presented with increased systolic (119 ± 9 vs 116 ± 8 mmHg,
P < 0.05) and diastolic (68 ± 5 vs 66 ± 6 mmHg, P < 0.05) blood pressures. EPT
exhibited reduced septal thickness (6.8 ± 0.8 vs 7.1 ± 1.1 mm, P < 0.05), left ven-
tricular (LV) internal dimension (46 ± 4 vs 48 ± 5 mm, P < 0.05), LV end-diastolic
(98 ± 20 vs 106 ± 24 ml/m2, P < 0.05) and end-systolic (36 ± 9 vs 40 ± 11 ml,
P < 0.01) volumes, right ventricular internal dimension (22 ± 3 vs 24 ± 4 mm,
P < 0.05), and LV mass (104 ± 27 vs 115 ± 30 g, P < 0.05), but similar LV mass
index and volume indexes. EPT exhibited increased LV myocardial performance
index (0.41 ± 0.04 vs 0.39 ± 0.04, P < 0.01), reduced mitral lateral e’ (17.6 ± 2.8 vs
19.1 ± 2.6 cm/s, P < 0.01), mitral s’ (10.7 ± 2.3 vs 11.6 ± 2.3 cm/s, P < 0.01), tri-
cuspid E’ (15.8 ± 2.7 vs 16.8 ± 2.1 cm/s, P < 0.05), and tricuspid S’ (13.1 ± 2.0 vs
14.0 ± 2.0 cm/s, P < 0.01) waves, and a trend in reduced mitral E wave (81 ± 14 vs
85 ± 15 cm/s, P = 0.09). EPT with neonatal BPD exhibited greater reduction in sep-
tal thickness (6.5 ± 0.8 mm, P < 0.05 vs terms and EPT without BPD), LV internal
dimension (45 ± 4 mm, P < 0.05 vs terms), LV Mass (98 ± 22 g, P < 0.05 vs terms),
and trend in reduced LV mass index (59 ± 10 g, P = 0.13 vs terms using T-test).
Conclusions: EPT exhibit cardiac structural and functional alterations compared
to term-born individuals. Neonatal BPD in EPT is a key contributor to long-term
left ventricular remodeling.
LB.03.02 CHRONIC HYPERTENSION IN PREGNANCY: A TEN
YEARS EXPERIENCE
M. Agostinis1, S. Moretti1, N. Tandurella1, A. Grossi1, G. Cavallaro1,
V. Pierobon1, L. Tavecchia1, V. Mancuso1, C. Mongiardi1, L. Montalbetti1,
A. Lippi1, A.M. Grandi1, L. Guasti1, A.M. Maresca1. 1Dipartimento di Medicina e
Chirurgia Università dell’Insubria, Varese, Italy
Objective: Hypertension affects 10% of pregnancies with rising incidence in
recent years; it represents a major cause both of maternal and fetal morbidity
and mortality. Aim of our study was to evaluate, retrospectively, the incidence of
gestational hypertension (GH) and preeclampsia (PE) in a sample of patients with
chronic hypertension (CH). We also evaluated the relationship between antihyper-
tensive therapy and development of complications during pregnancy.
Design and method: We retrospectively enrolled 77 pregnant patients with CH
(82 pregnancies). Patients were re-classified at the end of pregnancy in three
groups: CH, GH, PE. For each patient, we evaluated office blood pressure (OBP)
every 4 weeks until the 20th week, every two weeks until the end of pregnancy and
24 hours ambulatory blood pressure monitoring (24h-ABPM). We also assessed
proteinuria in the same periods.
Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved
Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
pregnancies. In 33.3% of CH, 41.4% of GH and 27.3% of PE, diagnosis of chron-
ic hypertension occurred during pregnancy. A significant difference was detected
whereas there were no differences on the type of delivery among the three groups.
increase in BP values. A significant difference was recorded in the first trimester
between IC and PE in 24h-SBP (p = 0.036), 24h-DBP(p = 0.04), daily 24h-SBP
(p = 0.036) and nocturnal 24hSBP(p = 0.019) contrary to what happened to OBP.
the three groups (CH and GH = 1.4,PE = 1.5), while in the course of pregnancy,
the drug load was significantly higher in PE compared to CH and GH(p = 0.015).
Conclusions: Our data confirm the need to give birth before term in women with
PE. We also showed how an early use of 24h-ABPM could help to identify among
patients suffering for CH those at hih risk to develop GH or PE.
LB.03.03 FOLLOW-UP RESULTS OF
ROENTGENOENDOVASULAR DESTRUCTION OF
ADRENAL GLAND IN PATIENTS WITH ESSENTIAL
HYPERTENSION
B. Tursunov1, H.U. smanov1, S. Temirov1, N. Kayumova2. 1The Central Hospital
of Ministry of the Internal Affairs, Tashkent, Uzbekistan, 2The Republic Center of
Internal Medicine and Medical Rehabilitation, Tashkent, Uzbekistan
Objective: To examine followup results of roentgenoendovascular destruction of
adrenal glands in patients with essential hypertension
Design and method: Reviewed results of roentgenoendovascular treatment on
1362 patients (763 males and 599 females, average 36,2 years, duration of arterial
hypertension accounted at an average 8,3 years), with essential hypertension. All
patients were underwent a complex examinations from routine blood and urine
analysis to abdominal aortography therefore it is excluded renal parenhimatous and
renovascular hypertension, hormonal active tumors of the adrenal glands. In these
patients arterial hypertension assessed as essential hypertension and found hyper-
plasia and hyperfunction of adrenal glands. A lesion has an asymmetrical character
as follows: hyperplasia in left adrenal only was found in 1264(92.8%) patients,
one in right only - in 16(1.2%) patients, and one in both adrenals revealed to be in
82(6%) patients. Hormonal investigations corroborated a presence of hyperfunc-
tion in adrenal cortex, specifically an increase in concentration of plasma aldoste-
rone and aldosteron renin ration was more than 20 ml.dl fixed in 84% patients. For
all patients done transluminal transvenous destruction of left adrenal glands.
Results: The mean blood sistolic and diastiolic pressure levels at the time of be-
fore treatment were 183 mmHg and 127 mmHg respectively. All patients had un-
successful hypotensive drug treatment history. The primary technical success of
transluminal adrenal destruction was 96% and complications observed in 7(0.6%)
patients, two of them fatal (retroperitoneal bleeding from perforated adrenal veins).
Kaplan-Meier analysis indicated 5- year free hypertension rate of 80.4% in pa-
tients after transluminal destruction of adrenal glands.
Causes of inefficacy of roentgenoendovascular destruction of adrenal gland or
relapse arterial hypertension in follow-up period were satellite renal parenchymal
disease, insufficient devitalization of adrenal glands and development of renal
artery stenosis and renovascular hypertenson.
Conclusions: In cases of excepted renal parenchymal disease and renovascular
hypertension, main cause of increasing arterial pressure (patients with essential
hypertension) is diffuse or diffusenodulous hyperplasia of adrenals, mainly of the
left adrenal gland with development of hyperaldosteronism. To oppress adrenal
hyperfunction and thereby to reduce arterial pressure it is possible by roentgeno-
vascular destruction of left adrenal gland.
LB.03.04 MODULATION OF MEMBRANE PROTEIN
EXPRESSIONS IN ALDOSTERONE INDUCED
HUMAN KIDNEY CELL VIA MICRORNAS
S. Karakurt. Selcuk University, Faculty of Science, Department of Biochemistry,
Konya, Turkey
Objective: Increased level of hypertension is found correlated with high aldoste-
rone level in the adrenal gland. Aldosterone has a crucial role in blood pressure
and its metabolism mainly controlled by modulation of relevant gene expressions