SCHOOL OF BIOTECHNOLOGY,

CHEMICAL & BIOMEDICAL ENGINEERING

Vellore 632 014, Tamil Nadu, India.

Neural Network in Bioinformatics LTPC: 3 0 0 3

Version No. 1.0.0
Course Prerequisites Analytical Bioinformatics, Introduction to Algorithms
Objectives: Solving modern biological problems requires advanced computational
methods.. Unstructured biological data into meaningful information.
Areas like data mining, machine learning, database technologies and
visualization techniques to problems like protein data analysis, genome
analysis and sequence databases.
Expected Outcome: 1. The students will be able to create a architecture and analyze protein
data from various databases.
2. The students will get a wide knowledge of designing the neural
network and train the network for biological applications.

Unit No. 1 Introduction to Neural Networks (NN) Number of hours: 9

The idea of "artificial neurons" - important concepts of artificial neural networks - two different types:
supervised vs. unsupervised, physiological neural networks,detection and prediction of sequence motifs
Unit No. 2 Types of NN Number of hours: 9
Important neural network concepts, feed-forward NN ,Input encoding-going for amino acids sequences
to numbers, The over-all principle - the components (nodes, weights) - the training procedure,
Recapitulation.
Unit No. 3 Applications for Neural Networks Number of hours: 9
The Biological Inspiration ,The Basic Artificial Model ,Using a Neural Network ,Gathering Data for
Neural Networks, An example application: TargetP - the biological problem - creating training sets - the
neural networks - sequence logos
Unit No. 4 Pre- and Post-processing Number of hours: 9
Multilayer Perceptrons -Training Multilayer Perceptrons, The Back Propagation Algorithm,Over-learning
and Generalization, Data Selection.
Unit No. 5 Classification in Neural Networks Number of hours: 9
Classification statistics,regression problems in neural networks,time series prediction in neural,networks
,variable selection and dimensionality reduction,ensembles and resampling.
Text Books 1. Bishop, C.Neural Networks for Pattern Recognition. Oxford: University Press.
1995.
2. Carling, A. Introducing Neural Networks. Wilmslow, UK. Sigma Press 1992.
3. Fausett, L. Fundamentals of Neural Networks. New York: Prentice Hall. 1994
References 1. Cathy H. Wu and Jerry W. McLarry – Neural Networks and Genome informatics.
Elsevier Science. 2000.
2. J. Zupan, J. Gasteiger – Neural Networks in chemistry and drug design. Wiley –
VCH.
Mode of Announced and Unannounced Quizzes, Assignments/ Seminars and Written
Evaluation Examination.
Recommended 13th November 2008
by the Board of
Studies on
Date of
Approval by the
Academic
Council

Proceedings of the 16th Academic Council held on 25.11.2008