Mekanisme Seluler
O Buat kelompok yang terdiri dari 4 orang mahasiswa!
O Temukan istilah-istilah yang menjadi menurut Anda menjadi kata kunci dalam
proses terbentuknya kanker!
O Petakan struktur apa saja yang terlibat dalam proses-proses terbentuknya Memahami mekanisme seluler terjadinya
kanker! kanker
O Apa peran dari masing-masing struktur yang terlibat dalam proses
terbentuknya kanker?
O Diskusikan dengan kelompok Anda, titik kritis yang menjadi faktor penentu
dalam proses terbentuknya kanker! Memahami keterlibatan komponen-komponen
O Tentukan pula upaya yang dilakukan dalam mencegah terbentuknya sel kanker! sel dan fungsinya dalam kanker
O Apa rekomendasi Anda dalam menangani kanker berdasarkan proses terbentuknya
sel kanker tersebut? Saran Anda dapat berupa rancangan obat yang dapat
mengatasi/menghambat proses pembentukan sel kanker.
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O 1:3 people is likely to suffer from cancer during their lifetime O Cancer is a group of diseases characterized by unregulated
O Siegel et al. (2011): ± 571, 950 Americans would die from cancer cell growth and the invasion and spread of cells from the site
in 2011, mortality rate (deaths/year/100.000 people) was over
200 for men in the UK in 2008 (Summary June 2011, Cancer of origin, or primary site, to other sites in the body
Research, UK) O Cancer is considered to be a group of diseases over 100
O The worldwide incidence: ± 12.7 million cases in 2008 (Jemal et types
al., 2011) O Origin off tissues
O Knowledge of the molecular details in important cellular and O Epithelial tissues (carcinomas) 85%
biochemical pathways can be applied to a new wave of cancer
O Mesoderm tissues (sarcomas)
therapies
O Glandular tissue (adenocarcinomas)
O The major factor that causes cancer in each target tissue O In the year 2000, upon fine analysis, Hanahan and Weinberg defined six
hallmarks of most, if not all, cancers
is different: ultraviolet (UV) radiation from the sun can O The capability for autonomous growth signals
easily target the skin, while inhalation of cigarette smoke O Evasion of growth inhibitory signals
can target the lungs O Evasion of apoptotic cell death
O Unlimited replicative potential
O There are differences in the molecular mechanisms O Angiogenesis (the formation of new blood vessels)
involved in carcinogenesis within each cell type and the O Invasion and metastasis are essential for carcinogenesis
O Two emerging hallmarks
pattern of spread of cells from the primary site O Reprogramming energy metabolism
O Treatment must be applied differently O Avoiding immune destruction
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O Avoiding immune destruction (emerging hallmark): O Tumor-promoting inflammation (an enabling characteristic):
O There is evidence to support the theory of immune surveillance that states the O Virtually all tumors contain inflammatory immune cells
immune system can recognize and eliminate cancer cells. O Inflammation is an immune response that can facilitate the ability of acquiring the
O Successful cancer cells may be those that do not stimulate an immune response or core hallmarks of cancer. For example, inflammatory cells can provide growth factors
can interfere with the immune response so as to avoid immune destruction. and enzymes that promote angiogenesis and invasion
O Unlimited replicative potential: O In addition, inflammatory cells can release oxygen species that are mutagenic.
O Normal cells have an autonomous counting device to define a finite number of cell O Invasion and metastasis:
doublings after which they become senescent. This cellular counting device is the O Normal cells maintain their location in the body and generally do not migrate
shortening of chromosomal ends, telomeres, that occurs during every round of DNA O The movement of cancer cells to other parts of the body is a major cause of cancer
replication deaths
O Cancer cells maintain the length of their telomeres O Alterations of the genome may affect the activity and/or levels of enzymes involved in
O Altered regulation of telomere maintenance results in unlimited replicative potential. invasion or molecules involved in cell–cell or cellular–extracellular adhesion.