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PATHOPHYSIOLOGY

HOST AGENT ENVIRONMENT


- female
- 48 years old Proliferative phase of the menstrual cycle
- GoPo obstetric score
Ovaries release estrogen into the uterus

Inner secondary glandular layer of the endometrium Estrogen stimulate the endometrium

Smooth muscle cells of the myometrium

Increased sensitivity to estrogen

Simple proliferation of
smooth muscle cells

Overgrowth of the smooth muscle cells

Submucosal fibroids
displace Tumor Compression of Obstruction of the Increased Abdominal Formation
endometrial tissue outgrows its blood vessels fallopian tubes pressure on the distention of peduncle
blood supply urinary bladder
Venous congestion sterility
hypogastric Torsion
Erosion of mucosal Degeneration Urinary Painful mass (twisting) of
surface of leiomyoma
Hyaline degeneration Varicosities frequency urination peduncle
Lower Extremities edema Pain upon
Cystic degeneration Hemorrhoids Lower back palpation
Bleeding in between Excessive Blood supply is
pain
periods bleeding during Mucoid degeneration cut-off
(metrorrhagia) menstruation
(menorrhagia) Fatty degeneration
Impede
implantation of Decrease blood Carneous degeneration
fertilized ovum volume
Calcification
necrosis
sterility Decreased venous return,
Sarcomatous
decerased cardiac output,
degeneration
decreased BP sepsis

Reduced renal Renal failure death


perfusion

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